Acarbose: tshuaj xyuas thiab tso cov ntawv, cov lus qhia rau kev siv

Acarbose yog ib tus neeg sawv cev hypoglycemic uas tau siv hauv kev kho mob los kho hom 2 ntshav qab zib mellitus. Hauv tsab xov xwm peb yuav txheeb xyuas seb acarbose yog dab tsi - cov lus qhia rau kev siv.

Saib xyuas! Hauv kev faib tawm qhov tseeb-tshuaj-tshuaj (ATX), "Acarbose" yog qhia los ntawm txoj cai A10BF01. Lub npe thoob ntiaj teb nonproprietary: Acarbose.

Pharmacodynamics thiab pharmacokinetics

Acarbose yog pseudotetrasaccharide uas yog cov tshuaj los ntawm actinomycetes. Cov tshuaj ua kom muaj kev sib tw thiab thim rov qab ua rau txoj hnyuv α-glucosidases kev koom tes hauv kev cuam tshuam ntawm di-, oligo- thiab polysaccharides. Hauv cov hnyuv me ntawm ib tus neeg, acarbose koob tshuaj-dependently qeeb lub rhuav tshem ntawm carbohydrates kom nqus monosaccharides (qabzib, fructose). Cov txheej txheem tiag tiag ntawm kev nqus ntawm acarbose tsis cuam tshuam.

Txij li thaum lub hydrolytic kev ua haujlwm ntawm cov glucosidases sib txawv tuaj yeem sib txawv ntawm cov tib neeg, nws tuaj yeem cia siab tias qhov nqus ntawm carbohydrates yuav txawv nyob ntawm qhov kev txhaj tshuaj tshwj xeeb. Lub cev tsis muaj roj txaus tsis tau daws teeb meem hauv txoj hnyuv (malabsorption), tab sis yog zom hauv plab hnyuv los ntawm cov kab mob mus rau cov xov luv fatty acids thiab roj cua. Fermentation khoom yog nqus thiab siv los ntawm lub cev.

Tsuas yog 1-2% ntawm cov tshuaj noj ntawm qhov ncauj yog muab nqus tsis pauv. Hauv cov hnyuv, metabolites yog tsim los ntawm cov enzymes digestive thiab cov kab mob hauv plab hnyuv. Kwv yees li ntawm 1/3 ntawm cov tshuaj noj hauv qhov ncauj yog nqus rau hauv cov ntshav hauv daim ntawv metabolized. Cov khoom lag luam metabolism Acarbose raug zais cia feem ntau los ntawm lub raum.

Kev taw qhia thiab contraindications

Hauv kev tshawb pom ob chav dig muag, qhov kev ntxim siab ntawm acarbose (100 mg peb zaug hauv ib hnub) piv nrog cov placebo tau kuaj hauv 94 tus mob ntshav qab zib rau 24 lub lis piam. Cov neeg mob tsis tau noj tshuaj tiv thaiv kab mob thiab tsis ua raws li kev noj haus tshwj xeeb. Ntawm cov sijhawm 4 lub lis piam sib tham, cov kws tshawb fawb tau ntsuas ntshav qabzib hauv lub plab thiab tom qab noj mov (400 kcal, 50% carbohydrates). Cov kws tshawb nrhiav tseem ntsuas lub siab ntawm glycated hemoglobin (Hb-A1), C-peptide, ntshav insulin, thiab triglycerides. Cov neeg mob hauv pawg neeg mob acarbose pom tias muaj kev txo qis glycemia tom qab noj mov (txog 5 teev tom qab noj mov): qhov nruab nrab ntshav qab zib cov ntshav (ib teev tom qab noj mov) yog 14.5 mmol / L ua ntej kev kho mob, thiab 10.5 mmol / tom qab noj acarbose l

Hauv cov placebo pawg, cov piam thaj tom qab noj mov tsawg dua. Qib HbA1 poob qis me ntsis nrog kev tso tawm acarbose (ntawm 9.3% mus rau 8.7%), thaum cov placebo tsis hloov. Acarbose kuj txo qis qib ntawm cov teeb meem tom qab tsis ntev ntawm cov tshuaj insulin thiab triglycerides.

Cov kev tshawb fawb txuas ntxiv yog ua nrog ntau tus neeg mob. Cov tshuaj no yog siv rau cov neeg mob ntshav qab zib sib txawv (los ntawm cov neeg mob uas tsuas xav tau kev noj haus kom tsuas yog mob ntshav qab zib muaj mob ntshav qab zib). Feem ntau, cov kev tshawb fawb no tau txais txiaj ntsig zoo ib yam li txoj kev kawm tau piav qhia saum toj saud: muaj ntau dua lossis tsawg tshaj tawm hauv glycemia tom qab noj thiab qis tso zis hauv lub cev. Muaj txiaj ntsig zoo ntawm kev yoo ntshav cov ntshav qabzib lossis HbA1c tau pom tias tsuas yog kev tshawb fawb ib leeg xwb. Feem ntau ntawm cov plasma insulin thiab lub cev qhov hnyav tsis tau hloov pauv hauv feem ntau cov kev tshawb fawb.

Hauv kev tshawb pom dig muag ob leeg, acarbose tsis tuaj yeem hloov qhov cuam tshuam ntawm sulfonylurea. Hauv 29 cov neeg mob, kev kho mob nrog sulfonylureas tau txiav tsis ua haujlwm ntxiv thiab hloov nrog acarbose lossis placebo. Cov koob tshuaj acarbose tau maj mam nce los ntawm 150 mg / hnub mus txog 500 mg / hnub. Tom qab 16 lub lim piam ntawm txoj kev kho, qib monosaccharide (ntsuas ntawm random) tau 50% siab dua, thiab HbA1 qib tau 18% siab dua nrog sulfonylurea. Acarbose thiab cov placebo tsis txawv ntau hauv lawv cov nyhuv.

Kev coj ntawm acarbose rau cov neeg mob uas muaj ntshav qab zib hom I txo qis glycemia. Qhov tseeb tias acarbose tuaj yeem tiv thaiv nocturnal hypoglycemia tsis tau raug pov thawj raws li cov ntaub ntawv luam tawm.

Sab meem: piav qhia

Cov tshuaj ua rau flatulence nyob rau hauv ntau tus neeg mob, tsis tshua muaj raws plab thiab mob plab. Ntau tshaj 50% ntawm cov neeg yws ntawm flatulence, kwv yees li 5% ntawm kev kho mob raug txiav vim yog mob plab zom mov.

Sij hawm dhau mus, cov tsos mob no yuav tsum poob qis. Tsawg dua li 5% ntawm cov neeg mob hnov ​​xeev siab, cem quav, lossis mob taub hau. Kev mob ntshav qab zib tsawg tsis tshwm sim ntau dua li siv cov placebo. Ib zaug rov qab hais txog, hloov tsis tau ntawm qhov kev hloov pauv tau pom, hauv qee qhov kev tshawb fawb txog 5% ntawm cov neeg mob tau cuam tshuam.

Tsuas tshuaj thiab tshaj

Acarbose muaj nyob hauv 100 mg ntsiav tshuaj. Qhov kev txhaj tshuaj thawj zaug feem ntau yog 50 mg 3 zaug hauv ib hnub, tom qab 1 txog 2 lis piam koj tuaj yeem siv cov tshuaj nruab nrab txhua hnub yog 300 mg. Siv tau koob tshuaj ntau ntxiv rau 600 mg / hnub. Cov ntsiav tshuaj yuav tsum nqos tag nrho cov kua ua ntej ua ntej noj mov.

Cov tshuaj yuav tsum tau sau ib leeg ib zaug thiaj li kom zam dhau kev mob plab zom mov tsis zoo. Hauv kev mob nyhav, nws pom zoo kom hloov pauv kev noj zaub mov thiab, tej zaum, txo qhov koob tshuaj.

Yog tias cov neeg mob tau mob monosaccharides ntshav tsawg nyob rau qee lub sijhawm ntawm hnub ntawd, nws raug nquahu tias yuav tsum tau kho dua. Cov neeg mob hnub nyoog qis dua 18 xyoo, thiab cov poj niam cev xeeb tub thiab lactating yuav tsum tsis txhob noj cov tshuaj no. Cov tshuaj, raws li txoj cai, tseem yuav tsum zam los ntawm cov neeg mob uas mob plab hnyuv.

Cov lus qhia rau kev siv tshuaj

Rau Acarbose, cov lus qhia rau kev siv qhia cov ncauj lus tiav txog cov nyhuv ntawm cov tshuaj ntawm lub cev.

Ua ntej siv, koj yuav tsum ua tib zoo nyeem cov tshuaj noj uas pom zoo thiab muaj qhov tsis zoo.

Cov tshuaj no yog faib los ntawm cov khw muag tshuaj tsuas yog tias muaj cov tshuaj los ntawm cov kws kho mob tuaj koom. Nyob rau tib lub sijhawm, tus nqi ntawm cov ntsiav tshuaj muaj rau txhua pawg ntawm cov pej xeem.

Cov koob tshuaj noj tau siv tau yog xam raws tus neeg mob lub cev qhov hnyav. Hauv qhov no, thawj koob tshuaj thawj zaug hauv thawj theem ntawm chav kawm kev kho yuav tsum tsis pub ntau tshaj nees nkaum-tsib milligrams. Cov ntsiav tshuaj yuav tsum tau noj peb zaug ib hnub ua ntej los yog thaum lub caij noj mov tseem ceeb.

Yog tias qhov qhia tau ntau npaum li cas tsis nqa ib qho txiaj ntsig zoo, hauv kev pom zoo nrog tus kws kho mob koom nrog, nws tuaj yeem nce ntxiv mus txog qhov ntau txog rau pua milligrams hauv ib hnub. Tus kws kho mob tshwj xeeb txiav txim cov koob tshuaj uas tsim nyog nyob ntawm tus neeg yam ntxwv ntawm tus neeg mob thiab nws cov duab hauv chaw soj ntsuam.

Nws tsis pom zoo kom nce cov tshuaj ntawm cov neeg laus, nrog rau cov uas muaj teeb meem ntawm lub siab ua haujlwm.

Cov tshuaj pib cuam tshuam ib teev tom qab siv nws. Nws txoj haujlwm ua ntev li ob teev. Yog tias cov tshuaj tau ploj lawm, tsis tas yuav tsum tau muab qhov koob tshuaj ntxiv rau ntawm kev siv txuas ntxiv. Acarose ua ke zoo nrog sulfonylureas, metformin derivatives lossis insulin los.

Lub chav kawm ntawm kev kho mob nrog yeeb tshuaj yuav tsum tau nrog txoj cai ntawm kev noj haus kom noj mov. Txwv tsis pub, kem plab tuaj yeem tshwm sim.

Kev npaj cov ntsiav tshuaj yuav tsum muab cia rau ntawm chav sov, zam qhov nruab hnub ncaj qha.

Tus nqi ntawm ib qho tshuaj txawv ntawm 350 txog 500 rubles rau ib pob (30 ntsiav tshuaj nrog tshuaj ntawm 50 mg).

Kev sib txuam

Adsorbents thiab cov enzymes digestive txo cov nyhuv tshuaj. Hauv cov neeg mob uas siv cov tshuaj hnoos, mob plab zom mov loj tau pom. Nws tsis pom zoo kom sib xyaw acarbose nrog ntau yam tshuaj laxative.

Lub ntsiab analogues (hloov chaw) ntawm cov tshuaj:

Lub tswv yim ntawm cov kws kho mob muaj peev xwm thiab cov neeg mob noj tshuaj.

Tus kws kho mob tau sau daim ntawv yuav tshuaj rau cov tshuaj, Raws li qhov kuv tuaj yeem tau yuav tom lub tsev muag tshuaj. Kuv siv ob peb lub hlis thiab pom tias qhov ntsuas ntawm glucometers yog maj mam zuj zus lawm. Kuv cov tshuaj tshwm sim ua rau mob siab me ntsis thiab xeev siab, uas ploj ntawm ib lub lim tiam tom qab kho.

Kev siv tshuaj hypoglycemic sai sai txo cov kev ua haujlwm ntawm cov piam thaj hauv cov ntshav, tsis muaj kev cuam tshuam nrog cov txiav ua kab mob ntshav siab. Lub ntsiab kom zoo dua yog qhov tsis muaj cov lus hais tawm uas tau siv thaum siv lwm cov tshuaj. Lub caij nyoog siv ua rau kev txo qis loj hauv glycemia.

Maxim Olegovich, kws kho mob ntshav qab zib

Nqe (hauv Lavxias Federation)

Cov tshuaj tam sim no siv feem ntau tsis tshua muaj ntshav qab zib. Nrog rau qhov tshuaj txhua hnub ntawm 300 mg ntawm acarbose, tus nqi kho yog 3000 rubles toj ib hlis. Rau kev sib piv, kev kho mob nrog glibenclamide (koob tshuaj txhua hnub: 7.5 mg ntawm micronized active ingredient) tus nqi qis dua 1000 rubles hauv ib hlis.

Tswv yim! Ua ntej siv ib qho tshuaj twg, koj yuav tsum tau sab laj rau tus kws kho mob tshwj xeeb kom tsis txhob muaj kev phom sij tshwm sim. Kev siv tus kheej yog txwv. Kev noj tshuaj rau tus kheej tuaj yeem ua rau qhov tsis txaus ntseeg thiab nyob rau qee kis, tshwm sim tsis txaus ntseeg. Rau txhua lub tswb, nrhiav tswv yim ntawm kws kho mob.