Neurontin - cov lus qhia ua ntej rau kev siv

Cov tshuaj yog ib qho ntawm cov anticonvulsants. Ua tsaug rau kev siv Neurontin, nws muaj peev xwm nres qhov mob uas tshwm sim rau ntawm keeb kwm ntawm neuropathic pathology.

Kev siv cov tshuaj Neurontin yog qhia rau:

• Mob hnyav neuropathic (kev qhia tshuaj rau cov neeg hnub nyoog tshaj 18 xyoo)
• Kev kho mob rau qee qhov qaug dab peg, tsis hais txog kev kho dav dav theem ob (raug kho rau cov menyuam muaj hnub nyoog 3 xyoos rau kev kho mob ntau, kev kho mob monotherapy ua tau los ntawm 12 xyoo)

Kev Sau thiab daim ntawv ntawm kev tso tawm

Neurotin ntsiav tshuaj muaj ib qho muaj txiaj ntsig, uas yog gabapentin, nws cov nyiaj hauv 1 ntsiav tshuaj yog 600 mg thiab 800 mg. Raws li kev piav qhia tseem muaj:

• Copovidone
• Stearic Acid Mg
• Talcum hmoov
• Polishing siv quav ciab
• Poloxamer
• Hmoov txhuv nplej siab
• Hydroxypropyl cellulose
• Thaj av dawb.

Cov tshuaj ntsiav muaj cov gabapentin hauv qhov tshuaj 100 mg, 300 mg lossis 400 mg. Muaj cov tsis suav nrog:

Cov tshuaj txau yog xim dawb (ntau npaum li 100 mg), daj daj (koob tshuaj 300 mg), ib yam li grey-txiv kab ntxwv (noj ntau npaum li 400 mg). Sab hauv txhua daim ntawv tshuaj yog ib cov hmoov dawb. Cov tshuaj ntsiav muab tso rau hauv lub hlwv ntawm 10 pcs., Muaj 5 lossis 10 blisters hauv lub pob.

Cov tshuaj dawb puag ncig muab ntim rau hauv ib lub hlwv blooj ntawm 10 pcs., Cov pob ntawv ntim nws muaj 2, 5 lossis 10 hlwv.

Kho thaj chaw

Gabapentin tau nrawm nrawm thiab yooj yim nkag mus tob rau hauv lub hlwb cov ntaub so ntswg, txwv tsis pub muaj kev pheej hmoo ua mob qee yam mob vwm. Cov tshuaj ua kom muaj zog yog ua rau muaj kev cuam tshuam rau GABA cov txais ntawm GABA thiab tsis cuam tshuam rau chav kawm ntawm kev hloov pauv ntawm GABA. Nws tsim nyog sau cia tias cov tshuaj nquag ntawm Neurontin tsis cuam tshuam nrog receptors ntawm lwm hom neurotransmitters uas muaj nyob hauv lub hlwb thiab tsis cuam tshuam ncaj qha rau ntawm cov sodium raws.

Gabapentin cuam tshuam nrog α-2-δ subunit ntawm voltage-gated calcium channel, raws li qee cov lus ceeb toom, qhov no yog dab tsi muab qhov pom ntawm cov nyhuv anticonvulsant thiab tshem tawm cov mob neuropathic.

Nrog rau qhov no, nws txo tus nqi ntawm glutamate-dependant cell cell tuag, ua rau muaj kev nce ntxiv hauv kev tsim GABA, uas ua rau txo qis hauv kev tso tawm ntawm neurotransmitters lawv tus kheej, uas tau suav nrog pawg monoamine.

Qhov siab tshaj plaws txog kev qhia txog kev noj qab haus huv yog kwv yees li 60%; nws qhov txo qis yog sau nrog qhov nce ntawm kev txiav ntawm cov tshuaj. Qhov siab tshaj plaws ntshav plasma tuaj yeem mus txog tom qab 2-3 teev tom qab cov ntsiav tshuaj tau qaug cawv. Lub koom haum ntawm gabapentin nrog plasma proteins yog qhov tsis zoo (txog 3%).

Ib nrab-lub neej tsis pub dhau 7 teev, tsis hais saib yuav tau noj tshuaj npaum li cas. Cov tshuaj tau tawm hauv nws cov qauv qub nrog kev koom tes ntawm cov hlwv rov qab.

Neurontin: cov lus qhia ua tiav rau kev siv

Tus nqi ntawm cov ntsiav tshuaj: los ntawm 1125 txog 1898 rubles. Nqe rau tsiav tshuaj: los ntawm 902 txog 1629 rubles.

Cov tshuaj yog pom zoo kom haus ob leeg thaum noj mov thiab tom qab.

Txheej txheem ntawm kev kho mob hauv cov neeg laus thaum mob neuropathic:

• 1 hnub - kev siv ib cov tshuaj nyob rau hauv ib qhov tshuaj ntawm 300 mg
• 2 hnub - nws raug nquahu kom haus 300 mg ntawm cov tshuaj ib hnub ob zaug
• 3 hnub - kev txais tos ntawm Neurontin 300 peb zaug hauv ib hnub yog qhia, qee qhov muaj peev xwm siv cov koob tshuaj no txij li pib kho
• Kev siv tom qab - kev noj tshuaj ntawm Neurontin yuav vam meej raws li qhov pom kev kho mob thiab qhov mob ntawm tus neeg mob, cov koob tshuaj tau tawm tsis hloov lossis nce ntxiv (qhov siab tshaj txhua hnub ntau ntawm cov tshuaj yog 3.6 g).

Cov koob tshuaj ntawm cov tshuaj thaum kho kev kho mob kom tsis txhob mob ib nrab ntawm cov neeg laus dua 12 xyoos yog xaiv tau raws li cov txheej txheem tau piav qhia saum toj no. Txhawm rau tiv thaiv kom rov tshwm sim ntawm qhov mob huam, koj yuav tsum noj tshuaj ntsiav lossis tshuaj ntsiav nrog lub sijhawm ntev li 12 teev.

Kev muab cov tshuaj rau cov menyuam yaus 3-12 xyoos nrog qee qhov qaug dab peg:

• Koob tshuaj raws li qhov hnyav
• Txij li 1 hnub ntawm kev kho mob, kev siv tshuaj triple nrog ib lub sijhawm tsis ntau dua 12 teev tau qhia
• Qhov pom zoo kom pib noj tshuaj txhua hnub yog 10-15 mg rau 1 kg
• Hauv thawj peb hnub, cov koob tshuaj ntawm cov tshuaj tau nce rau qib kev pom zoo
• Kev siv tshuaj zoo txhua hnub: rau cov menyuam yaus hnub nyoog 3-5 xyoos yog 40 mg rau 1 kg, txij li 5 txog 12 xyoos, koob tshuaj 25-35 mg rau 1 kg yog qhia.

Yog tias tsis ua haujlwm lub raum, nws raug nquahu kom txo cov koob txheem ntawm Neurontin. Thaum lub sij hawm xaiv cov koob tshuaj uas tsim nyog, nws tsim nyog xav tias yuav muaj cov cim creatinine tshem tawm.

Tom qab ua tiav kev kho mob, koj yuav tsum tau saib xyuas qhov mob kom yog li tus kws kho mob paub tseeb tias koj noj qab nyob zoo.

Cov Kev Tsis Txaus Ntseeg thiab Kev Ceev Faj

Nws tsis pom zoo siv tshuaj raws li gabapentin rau:

• Cov menyuam hnub nyoog (cov menyuam hnub nyoog qis dua 3 xyoos)
• Lub sijhawm ua haujlwm dhau los ntawm kev muaj feem cuam tshuam rau lub ntsiab loj.

Nrog kev ceev faj, kev kho mob yuav tsum tau nqa tawm hauv cov neeg laus thiab cov neeg mob lub raum pathologies.

Thaum lub sij hawm tswj hwm ntawm tsiav tshuaj thiab ntsiav tshuaj ntawm Neurontin, kev txhim kho ntawm kev tshem tawm cov tsos mob nrog kev tshwm sim tom qab ntawm kev huam mob huam tsis tuaj sau cia. Dua li ntawm qhov no, qhov sai sai ntawm kev kho mob nrog cov tshuaj anticonvulsant hauv cov neeg uas muaj qhov chua leeg ib nrab tuaj yeem ua rau lawv cov tsos.

Capsules suav nrog lactose, yog li cov neeg muaj mob malabsorption syndrome, galactose intolerance, thiab lactase deficiency yuav tsum tsis txhob siv lawv.

Hla kev sib txuam yeeb tshuaj

Thaum noj morphine (cov tshuaj no tau siv sij hawm li 2 teev ua ntej siv Neurontin), kev nce ntxiv ntawm qhov kev xav ntawm gabapentin los ntawm kwv yees li 44% tau sau tseg piv rau uas pom nrog kev kho mob monotherapy nrog Neurontin. Cov kev phiv tsis zoo ntawm morphine nrog kev siv sib xyaw ntawm gabapentin-based agents tsis txawv ntawm cov uas tau sau nrog kev siv morphine thiab placebo.

Tsis muaj qhov tshwm sim tsis zoo ntawm cov tshuaj raws li valproic acid, phenobarbital, carbamazepine, thiab phenytoin.

Thaum noj COCs, suav nrog norethindrone lossis ethinyl estradiol, tsis muaj kev hloov pauv hauv pharmacokinetics ntawm txhua cov tshuaj.

Thaum kho nrog antacids, suav nrog Al thiab Mg, qhov kev nyab xeeb ntawm gabapentin nws tus kheej yog ua tau txog li 20%.

Phiv thiab haus tshaj

Thaum kho nrog Neurontin, cov kev mob tshwm sim tsis zoo no yuav raug sau cia:

• Lub rooj zaum ua txhaum
• Tsis meej pem
• Qhov ncauj xav ntawm dryness
• Mob hauv plab thiab sab nraud
• Kev kho lub plab zom mov
• Mob taub hau heev
• Kev tsim cov hnoos thiab mob khaub thuas
• Qhov tshwm sim ntawm peripheral puffiness
• Los ntswg
• Kev hnyav hloov
• Txog siav
• Cov tawv nqaij ua pob
• Pharyngitis, mob ntsws
• Hloov pauv
• Kev nkees nkees
• Qhov tshwm sim ntawm hypersthesia.

Tsis tshua muaj neeg pom:

• Nystagmus
• Mob ntsws o
• Thab thab
• Ua kom tsis haum ntawm qee qhov reflexes
• Qhuas
• Qhov tshwm sim ntawm kev xav lability
• Cov cim qhia ntawm asthenia, ataxia
• Worsening ntawm kev xav
• Pob txuv ntxau
• Hyperkinesia
• Nkoov Yias
• Kev loj hlob ntawm amnesia
• Cov ua teb chaws

Thaum noj ntau tshaj, kev txhim kho ntawm cov tsos mob zoo li no tuaj yeem pom:

• Cov hais lus tsis meej
• Lub kiv taub hau heev
• Yuav tsaug zog heev
• Pom kev tsis pom kev
• Zawv plab.

Nws raug nquahu kom ntsuas kev ntsuas uas yog tsom rau ntawm kev tshem tawm cov tsos mob pom. Yog tias lub plab tsis zoo, yuav ua cov txheej txheem mob hemodialysis.

Yog tias tsim nyog, tus kws kho mob tuaj yeem pom zoo kom hloov Neurontin nrog analogues. Txais tos ntawm cov ntsiav tshuaj, tshuaj ntsiav (cov tshuaj uas muaj cov txiaj ntsig zoo ib yam) yog nqa tawm raws li kev xaiv tus kheej.

Artesan Pharma

Nqi los ntawm 352 txog 1127 rubles.

Cov tshuaj uas yog tus cwj pwm ntawm cov nyhuv antiepileptic. Nws raug nquahu kom coj los tshem tawm qee qhov qaug dab peg hauv cov menyuam yaus txij li 12 xyoo thiab cov neeg laus, nws zoo rau qhov mob, uas tau tsim tawm los ntawm neuralgia, neuropathy. Cov khoom nquag ua hauj lwm yog gabapentin. Muaj nyob rau hauv daim ntawv ntawm tsiav tshuaj nrog tshuaj ntawm 100 mg, 300 mg thiab 400 mg.

Pros:

• Nws muaj cov cim qhia analgesic nyhuv
• Zoo zam txim tau
• Tsis muaj pluas noj hauv lub siab.

Cons:

• Tej zaum provoke kev tsim cov leeg dystonia
• Contraindicated nyob rau hauv mob hnyav ua rau mob pancreatitis.
• Ceev faj yuav tsum tau ua nrog kev puas siab ntsws mob hlwb.