Amaryl M - cov tshuaj zoo uas pab txo cov ntshav qab zib

Hauv kev sib ntaus cov tiv thaiv ntshav qab zib sawv qhov ua tau zoo tshuaj German Amaril. Nws lub hom phiaj tseem ceeb yog los txo cov ntshav qab zib kom qis rau cov kev tsim txiaj. Cov kws kho mob sau ntawv thov Amaril rau cov neeg mob uas tau kuaj pom tus mob ntshav qab zib hom 2 uas yog siv tshuaj ntsuas mob ntshav qab zib. Txhawm rau kom tau qhov siab tshaj plaws los ntawm kev kho mob, koj yuav tsum noj tshuaj, nruj me ntsis rau cov kev siv tshuaj uas tus kws kho mob sau thiab tsis ntev dua lub sijhawm teev tseg. Txwv tsis pub, tus neeg mob raug hem nrog cov kev mob tshwm sim thiab cov nyom ntawm lub chav kawm ntawm tus kab mob.

TSEEM CEEB YUAV TSUM! Txawm tias cov ntshav qab zib siab tshaj plaws tuaj yeem kho tau hauv tsev, tsis tas yuav phais lossis tsev kho mob. Tsuas nyeem dab tsi Marina Vladimirovna hais. nyeem cov lus pom zoo.

Kev taw qhia thiab contraindications

Amaryl ntsiav tshuaj tau pom lawv daim ntawv thov hauv kev kho mob tsuas yog ib tus kab mob - hom II mob ntshav qab zib mellitus lossis cov tshuaj tiv thaiv kab mob ntshav qab zib tsis yog-insulin. Hom ntshav qab zib no tsis tuaj yeem kho mob nrog insulin, yog li cov tshuaj sib xyaw ua haujlwm zoo Amaril M tau tsim. Nws tsis pom zoo kom siv cov tshuaj qab zib rau cov neeg muaj kev tsis txaus siab rau nws cov khoom siv, nrog rau cov neeg uas tau kuaj pom muaj cov kab mob loj rau lub raum thiab mob siab, lactase deficiency thiab malabsorption (nqus tsis zoo) ntawm qabzib - galactose. Amaryl yog contraindicated nyob rau hauv hom 1 mob ntshav qab zib mellitus thiab nws qhov tshwm sim - tus kab mob ntshav qab zib ketoacidosis (ntau dhau ntawm ketone lub cev hauv cov ntshav). Tsis muaj tshuaj dab tsi yog tsim rau kev kho mob ntshav qab zib hauv cov poj niam hauv txoj hauj lwm, cov niam laus lossis cov neeg mob me.

Yuav siv li cas thiab noj li cas?

Nws raug nquahu kom noj Amaril rau cov ntshav qab zib tsuas yog tom qab sab laj nrog tus kws kho mob tsim nyog uas, ntawm cov ntshav qabzib hauv siab, yuav sau cov tshuaj kom zoo thiab ua kom zoo. "Amaryl" yog siv los kho hom 2 mob ntshav qab zib mellitus ob qho tib si li tshuaj tua kab mob thiab kho ua ke nrog lwm cov tshuaj. Feem ntau, chav pib pib nrog kev txhaj tshuaj me me, maj mam nce lawv rau hauv kev coj ua txhua hnub - 4 mg. Hauv cov xwm txheej hnyav, qhov tshuaj yuav ntau ntxiv rau 8 mg ib hnub.

Kho cov koob tshuaj ntawm cov tshuaj tsuas yog tom qab ntsuas ntshav qab zib.

Thaum kho ntshav qab zib, tus neeg mob yuav tsum ntsuas ntshav qabzib hauv cov ntshav, kom thaum thawj zaug nce ntxiv, kho tus nqi ntawm Amaril sai sai. Noj cov tshuaj noj thaum sawv ntxov ua ntej noj mov thawj zaug lossis ncaj qha thaum noj mov. Tsis txhob zom cov khoom noj, nqos nws thoob plaws, thiab haus cov dej ib nrab khob.

Sab sij huam

Thaum siv Amaril ntsiav tshuaj, cov xwm txheej tsis zoo hauv qab no yuav tshwm sim:

• txo qis hauv qab zib, cov qe ntshav dawb, granulocytes, platelets hauv cov ntshav,
• ntxhoo
• kev puas tsuaj cov ntshav liab lossis ua rau lawv txo cov ntshav tsawg,
• deficiency ntawm txhua hom hlwb nyob rau hauv cov ntshav,
• mob thiab tsis xis nyob hauv plab,
• kev fab tshuaj tsis haum
• kev saib duab
• nce kev ua si ntawm daim siab enzymes,
• ua rau lub siab ua haujlwm tsis zoo.

Hloov chaw

Thaum nws tsis tuaj yeem siv Amaril npaj tshuaj rau kev kho mob ntshav qab zib, cov kws kho mob tau sau ntawv noj tshuaj zoo ib yam li cov tshuaj yeeb tshuaj thiab pawg pharmacological. Yog li, ib qho ntawm cov analogues hauv qab no tuaj yeem hloov cov qab zib-txo Amaryl:

• Muaj ntau ntau cov analogues ntawm Amaril, ib tus ntawm yog Glemaz.

Cov lus qhia tshwj xeeb

Kev noj tshuaj "Amaryl" txhawm rau ua kom cov ntshav qab zib muaj zog, nws yog ib qhov yuav tsum tau saib xyuas kom tsis txhob muaj cov ntshav qabzib, kev ua haujlwm ntawm lub raum thiab mob siab, thiab tseem yuav saib xyuas cov ntshav sib xyaw kom thiaj li tiv thaiv tau cov ntshav tsawg, ntshav tsawg thiab ntshav liab. Nws tsim nyog teev cia tias qhov ua tau zoo ntawm cov tshuaj yuav txo qis yog tias tus neeg mob ntsib kev ntxhov siab ntau zaus thiab mob hnyav thiab qhov no yog vim muaj kev tso tawm ntau ntawm adrenaline rau hauv cov ntshav.

Nws yog qhov ua tau kom ntxiv dag zog los yog txo qis qhov kev ua ntawm Amaril, yog siv nrog rau lwm yam tshuaj. Yog li, nws yog qhov yuav tsum tau ceeb toom rau tus kws kho mob uas tuaj kawm txog cov tshuaj uas noj kom kws kho mob txo qhov ntau npaum li cas ntawm ib qho tseem ceeb lossis xaiv lwm yam tshuaj uas ib txwm ua nrog Amaril. Thaum kho ntshav qab zib, nws yog ib qho tsim nyog yuav tsum tshem tawm cov dej cawv, vim tias dej cawv ethyl hauv nws cov lus muaj peev xwm txo cov nyhuv ntawm cov tshuaj hypoglycemic. Cov tshuaj ntsiav yuav tsum tau muab cia rau qhov chaw txias, tiv thaiv los ntawm lub teeb thiab muab nkag rau me nyuam yaus. Txhawm rau kom Amaril tshuaj muaj txiaj ntsig zoo li sai tau rau kev mob ntshav qab zib mellitus, koj yuav tsum ua raws li kev noj haus hauv chaw soj ntsuam, ua lub neej muaj sia thiab ua raws txhua cov lus qhia ntawm koj tus kws kho mob.

Nws puas tseem zoo li tsis tuaj yeem kho ntshav qab zib?

Kev txiav txim los ntawm qhov tseeb tias koj tab tom nyeem cov kab no tam sim no, ib qho kev yeej ntawm kev tawm tsam cov ntshav qab zib hauv ntshav tsis nyob ntawm koj sab.

Thiab koj puas tau xav txog tsev kho mob? Nws yog kev nkag siab, vim tias ntshav qab zib yog ib qho txaus ntshai heev, uas, yog tias tsis kho, yuav ua rau muaj kev tuag. Kev nqhis dej ib txwm, tso zis ceev ceev, qhov muag plooj. Tag nrho cov tsos mob no yog paub txog koj tus kheej.

Tab sis nws puas tuaj yeem kho qhov laj thawj ntau dua li cov nyhuv? Peb pom zoo kom nyeem ib tsab xov xwm txog kev kho mob ntshav qab zib tam sim no. Nyeem kab lus >>

Cov Tshuaj Hauv Tshuaj

Glimepiride pab txo cov ntshav qabzib (feem ntau vim los ntawm kev ua kom muaj zog ntawm insulin los ntawm pancreatic cells-cells). Cov nyhuv no feem ntau yog ua raws li qhov tseeb tias pancreatic cells-hlwb txhim kho lub peev xwm los teb rau lub cev kev xav ntawm cov kua nplaum. Piv nrog rau glibenclamide, qis qis ntawm glimepiride ua rau tso qis qis ntawm insulin nrog kwv yees li qhov txo qis hauv qabzib, uas qhia tau hais tias muaj feem ua rau qhov tsis txaus siab ntawm glimepiride (cov nqaij muaj zog ntau ntxiv rau insulin, insulinomimetic effect).

Cov tshuaj insulin zais cia

Zoo li lwm yam sulfonylurea derivatives, glimepiride cuam tshuam rau cov kua dej los ntawm cov kua ntshav los ntawm kev ua yeeb yam ntawm ATP-nkagsiab potassium nyob ntawm pancreatic cell-cell daim nyias nyias.

Qhov sib txawv ntawm lwm cov sulfonylurea derivatives yog xaiv cov nyiaj ntawm glimepiride nrog cov protein muaj cov roj molecular ntawm 65 kilodaltons thiab muaj nyob hauv cov qog ntawm β-hlwb. Cov nyhuv ntawm glimepiride tso cai rau koj los kho cov txheej txheem ntawm kev kaw / qhib ntawm ATP-nkag siab potassium channel. Amaryl kaw cov kab xo potassium, uas ua rau depolarization ntawm β-hlwb, qhib voltage-rhiab calcium calcium raws thiab calcium ntws mus rau hauv lub cell. Nrog rau kev nce ntxiv ntawm cov calcium calcium uas tso siab ntxiv, insulin secretion los ntawm exocytosis ua haujlwm. Hauv kev sib piv nrog glibenclamide, glimepiride khi sai dua thiab ntau dua thiab raug tso tawm los ntawm cov kab ke nrog cov protein sib luag. Tej zaum, qhov hloov pauv siab ntawm glimepiride nrog cov protein txhawb cov lus tshaj tawm ntawm β-hlwb rau cov piam thaj, thiab tseem tiv thaiv lawv los ntawm desensitization thiab sai sai depletion.

Cov tshuaj Insulinomimetic

Cov nyhuv ntawm glimepiride zoo ib yam li cov nyhuv ntawm insulin hauv cov txheej txheem ntawm cov kua nplaum los ntawm cov leeg nqaij thiab nws tawm los ntawm daim siab.

Peripheral cov ntaub so ntswg nqus cov piam thaj los ntawm kev thauj mus rau hauv cov leeg nqaij thiab adipocytes. Glimepiride tsub kom ntau cov lwg me me thauj cov piam thaj thiab ua rau glycosylphosphatidylinositol-phospholipase C. Vim li ntawd, cov tshuaj calcium ntau ntxiv txo, uas ua rau kom cov protein kinase A kev ua haujlwm thiab kev ua kom lub cev metabolism. Nyob hauv kev cuam tshuam ntawm glimepiride, cov kua nplaum tawm los ntawm daim siab yog inhibited (vim muaj qhov nce ntawm cov ntsiab lus ntawm fructose-2,6-bisphosphate inhibiting gluconeogenesis).

Antiatherogenic siv

Glimepiride normalizes cov ntsiab lus ntawm lipids, txo qhov kev kub siab ntawm malondialdehyde hauv cov ntshav, vim qhov ntawd lipid peroxidation tseem ceeb txo. Hauv kev tshawb nrhiav tsiaj, nws tau pom tias kev noj glimepiride txo qis qhov tsim ntawm atherosclerotic plaques.

Glimepiride muab qhov txo qis ntawm qhov mob ua rau oxidative kev nyuaj siab ntawm tus yam ntxwv 2 mob ntshav qab zib mellitus, nce qhov nce ntawm endogenous alpha-tocopherol, nrog rau cov kev ua ntawm catalase, superoxide dismutase thiab glutathione peroxidase.

Kev mob plawv

Cov ntawv nyeem ntawm sulfonylureas cuam tshuam rau hauv lub xeev ntawm cov hlab plawv system, cuam tshuam rau ATP-nkag siab cov poov tshuaj raws. Piv nrog rau lwm cov sulfonylurea derivatives, glimepiride yog tus cwj pwm ntawm cov kab mob plawv qis dua, uas yuav cuam tshuam nrog cov txheej txheem tshwj xeeb ntawm nws cov kev sib txuas nrog cov protein ntawm ATP-rhiab potassium txuas ntxiv.

Qhov siab kawg rau kev noj qab nyob zoo hauv cov neeg ua haujlwm noj qab haus huv yog 0.6 mg. Cov nyhuv ntawm glimepiride yog kev rov ua dua thiab koob tshuaj.

Thaum noj Amaril, kev tawm dag zog ntawm lub cev rau kev qoj ib ce (txo qis insulin secretion) yog khaws cia.

Tsis muaj cov ntaub ntawv txaus ntseeg ntawm qhov sib txawv ntawm cov txiaj ntsig ntawm lub sijhawm ntawm kev noj tshuaj (thaum noj ncaj qha ua ntej noj mov lossis 0.5 teev ua ntej noj mov). Hauv cov ntshav qab zib mellitus, ib txoj kev tswj hwm nkaus xwb ntawm Amaril tuaj yeem muab cov kev tswj ntshav txaus txaus rau 1 hnub. Hauv qhov kev tshawb fawb soj ntsuam koom nrog 16 tus neeg tuaj yeem pab dawb raug kev txom nyem los ntawm lub raum tsis ua haujlwm (kev tsim tawm ntawm 4 mus rau 79 ml / min), kev tswj cov metabolic txaus tau ua tiav hauv 12 tus neeg mob.

Ua ke kev kho mob nrog metformin

Nrog cov tshuaj metabolic tsis txaus tswj hauv cov neeg mob noj qhov ntau tshaj plaws ntawm glimepiride, muaj qhov ua tau ntawm kev sib txuas ua ke nrog metformin thiab glimepiride. Hauv ob txoj kev tshawb nrhiav, kev sib txuas ua ke pom tau muaj kev nce siab hauv kev tswj cov metabolism thaum piv nrog kev kho cais nrog txhua cov tshuaj no.

Kev kho ua ke nrog insulin

Nrog kev tswj lub cev tsis tau txaus hauv cov neeg mob noj ntau tshaj plaws ntawm glimepiride, muaj tau muaj kev sib txuam nrog kev kho mob nrog metformin thiab insulin. Hauv ob txoj kev tshawb nrhiav, kev sib txuas ua ke pom tau hais tias nce kev tswj cov metabolism zoo ib yam li insulin monotherapy. Ntxiv mus, kev sib txuam ua ke yuav tsum tau siv tshuaj insulin tsawg dua.

Cov Tshuaj Pharmacokinetics

Nyob rau hauv cov ntaub ntawv rov ua dua ntawm cov tshuaj glimepiride ntawm ib koob ntawm 4 mg ib hnub, lub sijhawm nce mus txog qhov siab tshaj plaws nyob rau hauv cov ntshav cov ntshav yog li ntawm 2,5 teev, thiab qhov siab tshaj plaws ntshav plasma concentration ntawm cov tshuaj nquag yog 309 ng / ml. Qhov siab tshaj plaws ntshav plasma concentration ntawm glimepiride thiab thaj chaw hauv qab qhov nkhaus pharmacokinetic "concentration - sijhawm" linearly nyob ntawm koob tshuaj Amaril. Nrog kev tswj hwm ntawm qhov ncauj ntawm glimepiride, ua tiav kev paub tseeb txog kev nyab xeeb ntawm bioavailability. Kev nqus tau tsis yog cuam tshuam los ntawm kev noj zaub mov kom zoo (tshwj tsis yog kev qeeb me ntsis hauv kev nqus tau). Glimepiride muaj tsawg kawg ntawm kev faib khoom (

8.8 L), uas yog kwv yees li qhov sib npaug ntawm lub ntim ntawm faib albumin. Cov tshuaj yeeb dej caw yog yam ntxwv los ntawm kev siab ntawm kev khi rau cov ntshav plasma (tshaj li 99%) thiab tsis tshua muaj kev kub ntxhov (

48 ml / min). Kev txiav txim siab los ntawm ntshav dej nrog kev ua kom rov qab ua dua ntawm Amaril, qhov nruab nrab ib nrab-lub neej yog los ntawm 5 txog 8 teev. Nyob rau hauv cov ntaub ntawv ntawm cov koob tshuaj zoo, ib nrab-lub neej yog me ntsis nce.

Raws li kev soj ntsuam ib zaug ntawm lub qhov ncauj ntawm glimepiride, 58% ntawm cov koob tshuaj tau tawm los ntawm lub raum, thiab 35% ntawm cov koob tshuaj los ntawm cov hnyuv. Hauv cov zis, tsis hloov pauv glimepiride tsis pom.

Hauv cov quav thiab tso zis, ob lub cev tsim hauv lub siab raug kuaj pom (feem ntau nrog kev koom tes ntawm CYP2C9 isoenzyme), ib qho yog tus carboxy derivative, thiab lwm qhov yog hydroxy derivative. Tom qab lub qhov ncauj tswj hwm, qhov kev tshem tawm davhlau ib nrab-lub neej ntawm cov metabolites no yog 5-6 thiab 3-5 teev, feem.

Cov tshuaj nquag hla dhau ntawm qhov tso cov nyom thiab tso rau hauv cov kua mis.

Thaum muab piv rau ib qho thiab ntau koob ntawm glimepiride, tsis muaj qhov sib txawv hauv pharmacokinetic, thiab lawv qhov kev hloov pauv tsawg tsawg tau pom hauv ntau cov neeg mob. Tsis muaj qhov tseem ceeb zuj zus ntawm cov tshuaj nquag.

Hauv cov neeg mob ntawm cov hnub nyoog sib txawv thiab cov tub los ntxhais, cov teeb meem pharmacokinetic zoo sib xws. Yog tias muaj teeb meem lub raum tsis zoo (nrog rau qhov tsis muaj creatinine tshem tawm), qhov nce ntawm kev tshem tawm ntawm glimepiride thiab qhov txo qis hauv nws qhov nruab nrab hauv cov ntshav siab yog ua tau. Hauv txhua qhov kev muaj peev xwm, qhov no yog vim muaj qib siab dua ntawm qhov kev zam ntawm cov tshuaj vim tias qis dua qib ntawm cov protein khi. Raws li, nyob rau hauv pawg no ntawm cov neeg mob tsis muaj kev pheej hmoo ntawm Amaril tsub zuj zuj.

Kev ntsuas rau siv

Raws li cov lus qhia, Amaryl tau sau tseg rau cov mob ntshav qab zib hom 2 (ntshav qab zib tsis yog insulin-ntshav qab zib).

Cov tshuaj ua kom muaj zog glimepiride pab txhawb kev tsim cov tshuaj insulin los ntawm tus txiav thiab nws nkag mus rau hauv cov ntshav. Cov tshuaj insulin, nyeg, txo cov suab thaj hauv cov ntshav. Glimepiride txhim kho cov poov tshuaj metabolism hauv cov hlwb, thiab tseem pab txhawm rau tiv thaiv kev tsim cov atherosclerotic plaques ntawm cov phab ntsa ntawm cov hlab ntshav.

Cov Yuav Tsum Muaj

Amaryl yog contraindicated nyob rau hauv cov kab mob nram qab no:

• Yam 1 ntshav qab zib mellitus (insulin-dependant),
• Tus mob ketoacidosis (yam mob 1 yam ntshav qab zib)
• Mob raum thiab mob siab,
• Mob ntshav qab zib coma thiab nws precoma,
• Cov kua dej qab zib-galactose malabsorption, lactase deficiency, galactose intolerance,
• Cov me nyuam lub hnub nyoog
• Ib tug neeg tsis qaug rau ib qho Amaril tivthaiv,
• Cev xeeb tub thiab lactation.

Cov lus qhia rau kev siv Amaril: txoj kev thiab ntau npaum li cas

Raws li cov lus qhia, Amaryl yuav tsum noj qhov ncauj tsis noj, tsis txhob ntxo, tam sim ua ntej lossis thaum noj tshais, haus dej ntau (tsawg kawg ½ khob). Kev noj tshuaj yuav tsum raug khi rau txoj kev noj mov, txwv tsis pub muaj cov ntshav qab zib kom tsawg.

Cov tshuaj rau txhua tus neeg mob yog xaiv tau los ntawm tus kws kho mob koom nrog, nyob ntawm seb muaj suab thaj hauv cov ntshav.

Txoj kev kho mob pib nrog feem ntau Amaril - 1 mg ib hnub twg. Nyob ntawm seb tus mob ntawm tus neeg mob, tus kws kho mob tuaj yeem maj mam (ib zaug txhua 1-2 lub lis piam) nce kev noj tshuaj ntawm Amaril, ua raws cov txheej txheem: 1-2-3-4-6 mg. Kev siv tshuaj rau feem ntau yog 1-4 mg ib hnub.

Yog hais tias tus neeg mob tsis nco qab lees txais qhov yuav tsum noj txhua hnub, tom qab ntawd cov tshuaj ntxiv yuav tsum tsis txhob ntxiv zog. Cov kev coj ua txhaum cai los ntawm kev ua txhaum txoj cai kev kho mob yuav tsum tham nrog tus kws kho mob ua ntej.

Thaum lub sij hawm siv cov Amaril, tswj cov ntshav qab zib yog qhov tsim nyog.

Noj ntau dhau

Yog tias muaj kev pheej hmoo sai dhau lossis thaum siv tshuaj kho ntev nrog cov tshuaj glimepiride nce siab, yuav muaj kev pheej hmoo los ntawm kev mob ntshav qab zib siab nrog lub neej tsis zoo.

Thaum kuaj pom kev noj ntau dhau, nrhiav kev pab kho mob tam sim ntawd. Yuav luag txhua lub sijhawm, hypoglycemia tuaj yeem nres sai sai los ntawm kev noj zaub mov sai sai (ib qho qab zib, piam thaj, tshuaj yej lossis kua txiv qab zib), yog li tus neeg mob yuav tsum muaj 4 daim piam thaj nrog nws (20 g piam thaj).Cov khoom qab zib hauv kev kho mob ntawm hypoglycemia yog qhov tsis muaj txiaj ntsig.

Tus neeg mob yuav tsum tau saib xyuas mob nkeeg kom txog thaum tus kws kho mob txiav txim siab tias tsis muaj kev phom sij txog kev phom sij. Nws yuav tsum tau yug los hauv lub siab qhov rov ua tau ntawm kev rov qab kho ntawm hypoglycemia tom qab kev kho dua ntawm cov piam thaj hauv cov ntshav.

Thaum kho cov neeg mob ntshav qab zib nrog cov kws kho mob sib txawv (piv txwv li, nyob rau hnub so lossis thaum nkag mus hauv tsev kho mob los ntawm kev raug mob), nws yuav tsum qhia txog nws tus mob, nrog rau kev kho mob dhau los.

Qee qhov xwm txheej, yuav tsum tau mus pw hauv tsev kho mob. Ib qho kev noj tshuaj ntau dhau nrog qhov muaj kev tsis haum (tsis nco qab lossis lwm tus mob hlwb loj) yog hais txog kev kho mob xwm txheej ceev thiab yuav tsum tau mus pw hauv tsev kho mob thiab kho tam sim ntawd.

Thaum tus neeg mob nyob hauv lub xeev tsis nco qab lawm, qhov xav tau ntawm cov dej qab zib (dextrose) ntawm 20% yog muab tshuaj rau qhov quav (rau cov neeg laus, ib txog 40 ml ntawm cov tshuaj yog qhia). Rau cov neeg laus, lwm txoj kev kho mob lwm txoj kev kho mob yog cov tshuaj ntshav, tshuaj ntshav los yog tshuaj tswj ntshav qab zib (nyob ntawm 0.5 txog 1 mg).

Yog tias Amaril tau raug yuam los ntawm cov menyuam yaus lossis menyuam yaus, cov tshuaj dextrose noj thaum lub sijhawm hypoglycemia yuav tsum tau ua tib zoo kho kom coj mus rau hauv tus account yuav muaj kev phom sij hyperglycemia. Kev qhia ntawm dextrose yuav tsum tau ua nyob rau hauv kev soj ntsuam tas li ntawm cov piam thaj hauv cov ntshav.

Thaum noj ntau dhau, lub plab zom mov thiab lub sij hawm teem caij kom ua hluav ncaig.

Kev ceev ceev ntawm cov ntshav qabzib yuav tsum muaj kev tswj hwm qhov tso siab ntawm kev txiav txim siab qis ntawm cov tshuaj dextrose kom thiaj li tiv thaiv tau qhov rov qab ua ntawm hypoglycemia. Hauv cov neeg mob no, cov concentration ntawm cov piam thaj hauv cov ntshav yuav tsum tau saib xyuas tas li 1 hnub. Thaum mob hnyav nrog lub caij nyoog ntev ntawm cov ntshav qog ntshav qab zib, txoj kev pheej hmoo ntawm txo cov ntshav qabzib mus rau qib ntshav hypoglycemic tseem nyob rau ob peb hnub.

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, siv cov Amaril yog contraindicated. Nrog kev npaj cev xeeb tub lossis nrog qhov pib ntawm cev xeeb tub thaum kho tshuaj, ib tug poj niam yuav tsum pauv mus rau kev kho mob insulin.

Txij li thaum glimepiride raug nthuav tawm hauv niam cov kua mis, kev siv Amaril hauv kev pub mis niam yog contraindicated. Hauv qhov no, kev hloov mus rau kev kho tshuaj insulin lossis kev txiav tu niam mis yog qhov qhia tau.

Yeeb tshuaj sib cuam tshuam

Glimepiride yog metabolized los ntawm isoenzyme CYP2C9 ntawm cytochrome P4502C9 system, uas yuav tsum tau coj mus rau hauv tus account thaum siv ua ke nrog inducers (piv txwv li rifampicin) lossis CYP2C9 inhibitors (e.g. fluconazole). Thaum ua ke nrog cov tshuaj hauv qab no, potentiation ntawm hypoglycemic kev ua yuav tshwm sim, thiab qee qhov kev loj hlob ntawm hypoglycemia vim qhov no: insulin thiab lwm yam tshuaj hypoglycemic rau qhov ncauj tswj hwm, angiotensin-hloov enzyme inhibitors, txiv neej pw ua ke, anabolic steroids, coumarin derivatives, chloramphenicol, disopramide, , pheniramidol, fenfluramine, fluoxetine, fibrates, ifosfamide, guanethidine, monoamine oxidase inhibitors, fluconazole, pentoxifylline (hauv Raug huab parenteral koob tshuaj), p-aminosalicylic acid, azapropazone, phenylbutazone, probenecid, oxyphenbutazone, salicylates, quinolones, clarithromycin, sulfinpyrazone, tetracyclines, sulfonamides, trofosfamide, tritokvalin.

Thaum ua ke nrog cov tshuaj uas tau teev hauv qab no, hypoglycemic kev txiav txim siab tuaj yeem ua kom tsis muaj zog, nrog rau kev nce ntxiv hauv cov ntshav qabzib txuam nrog nws: acetazolamide, glucocorticosteroids, barbiturates, diuretics, epinephrine, lwm yam tshuaj sympathomimetic, glucagon, nicotinic acid (koob tshuaj), tshuaj laxatives (hauv mob ntawm kev siv ntev), progestogens, estrogens, rifampicin, phenytoin, phenothiazines, iodine-muaj cov thyroid hormones.

Thaum siv ua ke nrog beta-blockers, N blockers₂-histamine receptors, clonidine thiab reserpine, ob qho tib si ua kom tsis muaj zog thiab ua kom lub zog hypoglycemic ntawm glimepiride muaj peev xwm ua tau.

Thaum noj tshuaj sympatholytic (beta-blockers, guanethidine, reserpine thiab clonidine), cov cim ntawm adrenergic counterregulation nrog hypoglycemia tej zaum yuav qhaj ntawv lossis ploj zuj zus.

Kev sib xyaw ua ke ntawm glimepiride thiab coumarin derivatives tuaj yeem txhim kho lossis txo cov nyhuv ntawm tom kawg.

Xws li kev siv dej cawv ib zaug lossis ntev mus ntev, cov nyhuv hypoglycemic ntawm glimepiride tuaj yeem nce ntxiv thiab txo qis.

Siv nrog cov kua tsib acid sequestrants: rau lub log lover, hu rau glimepiride, txo nws txoj kev nqus los ntawm txoj hnyuv, nrog rau kev siv glimepiride 4 teev ua ntej noj lub log lover sib cuam tshuam tsis tau sau tseg.

Cov tshuaj hauv qab no yog cov qauv ua qauv ntawm Amaril: Glemaz, Glymedeks, Meglimid, Diamerid, Glemauno.

Kev Rov Ntsuam Xyuas Amaril

Kev tshuaj xyuas ntawm Amaril qhia tau hais tias tus yuam sij rau kev ua haujlwm ntawm cov tshuaj yog xaiv qhov tseeb ntawm kev txiav txim ntawm koob tshuaj thiab kev kho mob kiag li. Tib lub sijhawm, qee cov lus ceeb toom muaj cov ntaub ntawv uas nyob rau theem pib ntawm kev noj tshuaj Amaril hauv cov neeg mob, cov ntshav qab zib hauv cov ntshav tau hloov pauv ntau yam. Raws li cov kws tshaj lij, qhov tshwm sim no tuaj yeem daws tau los ntawm kev kho lub koob tshuaj los ntawm tus kws kho mob (nrog rau kev siv tshuaj tsis haum, qhov kev pheej hmoo ntawm kev tsim cov kev mob tshwm sim).

Cov khoom tseem ceeb ntawm cov tshuaj

Cov khoom siv tseem ceeb uas yog ib feem ntawm cov tshuaj - glimepiride (Latin lub npe - Glimepiride) cuam tshuam txog kev tso tawm ntawm cov tshuaj insulin.

Ua tsaug rau cov tshuaj tivthaiv no, cov tshuaj muaj cov nyhuv txiav pancreatic.

Nrog rau kev tso tawm qhov hormone los ntawm beta hlwb, ib qho tseem ceeb txo cov ntshav qab zib cov ntshav tau tshwm sim. Cov txheej txheem zoo sib xws ntawm kev ua haujlwm tau cuam tshuam nrog kev txhim kho hauv qhov rhiab ntawm beta hlwb rau cov piam thaj.

Ntxiv nrog rau qhov tseem ceeb tivthaiv, cov khoom sib txuas hauv qab no ntxiv nrog cov tshuaj muaj pes tsawg leeg:

• povidone
• lactose monohydrate,
• indigo carmine
• magnesium stearate,
• microcrystalline cellulose.

Tsis tas li ntawd, cov tshuaj noj tswj kev ua haujlwm ntawm pancreatic hormone. Qhov no yog vim muaj kev sib cuam tshuam ntawm glimepiride thiab metformin nrog cov kab xo potassium nyob ntawm beta cell membrane. Qhov khi ntawm cov nquag tivthaiv rau cov protein tswj kev ua haujlwm ntawm lub channel, hu ua, kaw thiab qhib.

Amaryl muaj cov txiaj ntsig ntxiv - nws txhim kho cov tshuaj insulin los ntawm cov leeg nqaij thiab cov nqaij mos adipose. Qhov no tshwm sim vim yog los ntawm kev thaiv cov potassium nyob hauv lub cell membrane thiab kev noj cov calcium ntau ntxiv hauv cov cell. Cov txiaj ntsig ua ke ua rau txo qis hauv insulin tsis kam, tab sis kuj cuam tshuam me ntsis ntawm kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha.

Qhov siab tshaj plaws ntawm cov tshuaj nquag tau tiav nrog kev siv ntau. Piv txwv li, thaum noj 4 mg ntawm glimepiride ib hnub, qhov kev xav ntau tshaj yog ua tiav hauv 2.5 teev.

Ua kom tiav qhov nqus ntawm cov tshuaj tiav tiav thaum ua tiav qhov ncauj. Kev noj zaub mov kom qeeb ntawm txoj kev ua kom zoo ib yam ntawm cov tshuaj, tab sis cov nyhuv no tsis pom zoo. Kev tshem tawm glimepiride dhau los ntawm txoj hnyuv thiab lub raum.

Daim ntawv teev cov kev ntsuas thiab qhov sib txuam rau kev txais mus kawm

Amaryl muaj qhov taw qhia hauv qab no rau kev siv. Qhov loj tshaj plaws yog kev kho mob ntshav qab zib hom 2. Amaril tsuas yog ob qho tib si rau cov neeg mob uas tsis xav tau kev txhaj tshuaj insulin, thiab rau cov neeg uas tau qhia insulin los txhim kho lawv qhov zoo.

Hauv kev kho mob ntshav qab zib, Amaryl ntsiav tshuaj tau sau tseg yog cov tshuaj tseem ceeb. Tab sis nrog kev tswj tsis tau txaus metabolic (tshwj xeeb yog tias tus neeg mob tau noj tshuaj ntau npaum li cas), Glimepiride txuam nrog Metformin yog tshuaj. Qhov no tuaj yeem txhim kho kev tswj cov metabolism. Hauv qhov no, cov txiaj ntsig tau zoo dua piv rau cov ua tiav nrog kev cais tawm ntawm cov tshuaj.

Cov txiaj ntsig zoo ua tiav los ntawm cov kev kho mob nyuaj siv Glimepiride thiab Metformin ua rau kev txhim kho ntawm cov tshuaj Amaryl M. Daim ntawv sau tshuaj tau muab rau cov tshuaj no yog tias kev kho mob ntshav qab zib mellitus nrog cov tshuaj nyuaj tsim nyog, uas yooj yim rau cov neeg mob.

Tshuaj Amaril uas txo qis cov ntshav qab zib tuaj yeem siv rau hauv cov neeg mob uas xav tau kev txhaj tshuaj insulin tsis tu ncua. Tib lub sijhawm, kev tswj kev zom zaub mov kuj tseem tuaj yeem txhim kho, tab sis qhov ntau npaum ntawm glimepiride raug pom zoo kom txo qis.

Zoo li txhua yam tshuaj, cov tshuaj tsis tuaj yeem pom tias muaj kev nyab xeeb kiag li. Amaril muaj contraindications, thiab lawv cov npe yog qhov loj heev.

Ua ntej tshaj plaws, nws raug nquahu kom ceev faj txog kev noj tshuaj thaum thawj theem ntawm kev kho mob: lub sijhawm no, tseem muaj kev pheej hmoo ntawm kev txo qis hauv qabzib. Yog tias dhau sijhawm dhau qhov kev pheej hmoo ntawm hypoglycemia tseem tshuav, nws raug nquahu kom hloov pauv kev kho mob lossis noj tshuaj ntawm Amaril. Koj yuav tsum ua tib zoo saib xyuas thiab muaj qee yam kabmob, kev ua neej tsis raug, kev noj tsis tau.

Cov kab mob hauv qab no (lossis tej yam kev mob ntawm lub cev) yog lub ntsiab lus tseem ceeb rau kev teem caij ntawm Amaril:

1. Mob plab zas lossis yog poj koob yawm txwv.
2. Ketoacidosis.
3. Mob rau daim siab thiab mob raum.
4. Kev tsis nkag siab lossis txo qhov mob siab rau qhov tseem ceeb lossis ntxiv rau cov tshuaj.
5. Tsis tshua muaj kab mob yug (lactose intolerance, lactase deficiency, thiab lwm yam).
6. Cev xeeb tub Thaum npaj kev xeeb tub, yuav tsum hloov chaw kho mob. Tus neeg mob pauv mus rau kev txhaj tshuaj insulin, cov tshuaj tsis raug txwv.
7. Thaum pub niam mis, kev kho mob insulin txuas ntxiv. Yog hais tias rau ib qho laj thawj twg qhov kev kho mob no tsis haum, Amaril tau sau tseg rau tus neeg mob, tab sis nws raug nquahu kom tsum tsis txhob lactation.

Cov tshuaj tsis raug txwv rau kev kho mob ntshav qab zib hom I. Ib qho tseeb contraindication yog me nyuam lub hnub nyoog. Tsis muaj ntaub ntawv hais txog kev haus tshuaj rau menyuam yaus.

Yog li, rau kev kho mob ntshav qab zib hauv cov menyuam yaus, kev noj qab haus huv zoo dua ntawm cov tshuaj feem ntau yog kho.

Phiv phiv ntawm kev siv tshuaj

Raws li kev noj Amaril, kev mob tshwm sim yuav tshwm sim.

Hauv qee kis, muaj kev pheej hmoo ntawm kev ua haujlwm tsis zoo ntawm ntau yam kabmob thiab cov kabmob ntawm lub cev.

Ntawm ib feem ntawm cov metabolism, hypoglycemic ຕິ ຊົມ yog cai. Lawv feem ntau tshwm sim sai heev, tab sis nyuaj nyuaj kho.

Qee cov tshuaj ntshav qab zib ua rau lub hauv nruab nrog hlab ntsha tsis zoo.

Cov uas noj Amaryl muaj cov tsos mob zoo li no:

• kiv taub hau
• tsis hnov ​​lus
• ua txhaum ntawm kev sib koom tes
• maj mam tawm hauv cov tshuaj tiv thaiv
• pw tsis taus
• rov quav niab lossis tsis nco qab
• nyuaj siab lub xeev
• hais lus tsis taus
• kev poob siab, ntxhov siab, thiab lwm yam.

Qhov tshwm sim ntawm kev noj cov tshuaj raws li kev ua txhaum ntawm lub plab zom mov yog tshwm sim ntau. Lawv tuaj yeem tshwm sim los ntawm qhov mob hauv plab lossis plab, xeev siab, zawv plab, ntuav, nce kev tshaib plab.

Vim tias qhov tshwm sim ntawm glimepiride, kev txo qis hauv qabzib yog qhov ua tau, uas tuaj yeem cuam tshuam tsis zoo rau lub xeev ntawm cov plab hnyuv siab raum ntawm lub zeem muag, uas tuaj yeem ua rau tsis pom kev.

Cov tshuaj cuam tshuam rau cov txheej txheem tsim ntshav, uas tuaj yeem tsim kev txaus ntshai ntawm kev hloov pauv xws li:

1. Mob Kev Plab
2. Thrombocytopenia (ntawm qhov sib txawv zuj zus).
3. Pancytopenia.

Tsawg dua li cov qauv kev tsis haum:

• khaus
• daim tawv nqaij ua pob
• daim tawv liab
• vasculitis.

Tom qab siv tshuaj Amaril, cov kev qhia tshuaj tiv thaiv ua xua feem ntau me me thiab kis tau sai nrog kev kho mob kom raug.

Tab sis nws yog ib qho tseem ceeb tshaj plaws los pib kho mob kom raws sij hawm: qhov phom sij ntawm qhov tsis txaus ntseeg tseem ceeb.

Cov lus qhia rau kev siv tshuaj

Kev kho tau zoo yog ua tsis tau yam uas tsis ua raws li cov lus qhia rau kev siv Amaril. Txoj cai tswjfwm ntawm lub luag haujlwm yog tias lub ntsiav tshuaj yuav tsum tsis txhob ua kom ntsoog. Siv cov tshuaj Amaril 3 kom tag nrho, kom muaj dej txaus kom nws nqos tau yooj yim.

Cov tshuaj zoo ntawm Amaril raug suav xam ntawm tus kheej rau tus neeg mob. Lub luag haujlwm tseem ceeb uas tau siv thaum sau daim ntawv noj tshuaj yog qhov tsis txaus siab ntawm cov piam thaj hauv cov ntshav. Kev noj tshuaj me me tshaj plaws yog qhov kev kho mob yuav pab tau tswj kev zom zaubmov. Ntxiv nrog rau cov piam thaj hauv qib, hauv cov lus qhia ntu cov txheej txheem ntawm kev siv tshuaj qhia tau hais tias kev saib xyuas tas li tsis tsuas muaj cov piam thaj hauv ntshav, tab sis kuj tseem glycated hemoglobin yog qhov tsim nyog.

Yuav muaj qee qhov xwm txheej thaum tus neeg mob tsis nco qab noj Amaril ntsiav tshuaj raws sijhawm. Hauv cov xwm txheej zoo li no, rov ntxiv qhov nyiaj ntawm cov tshuaj los ntawm kev muab ob npaug rau koob tshuaj tsis pom zoo. Feem ntau ntau npaum li cas cov tshuaj tau zoo ib yam, cov ntsiav tshuaj ploj tsis tau ntxiv. Nws yog qhov zoo dua rau tham nrog tus kws kho mob ua ntej txog cov kev coj ua hauv cov xwm txheej zoo li no.

Thawj theem kev kho mob, cov neeg mob tau xaj Amaryl 1 mg rau ib hnub. Lub sijhawm dhau los, yog tias tsim nyog, maj mam nce ntxiv ntawm koob tshuaj los ntawm 1 mg yog tso cai, thawj zaug txog 6 mg rau ib hnub, thiab tom qab ntawd txog li 8 mg. Nrog kev tswj tus kab mob li qub, kev muab tshuaj ntau tshaj plaws tsis pub tshaj 4 mg ib hnub. Qhov tshuaj loj dua 6 mg ib hnub twg tsis tshua muaj peev xwm ua kom pom kev txhim kho. Tus nqi ntawm cov tshuaj hauv 8 mg yog tau sau tseg hauv kev tshwj xeeb.

Lub sijhawm nruab nrab ntawm txhua qhov nce ntawm cov tshuaj yog txiav txim siab los ntawm tus neeg mob thiab qhov ua tau zoo ntawm kev siv tshuaj ntau npaum li cas, tab sis yuav tsum tsis pub tsawg dua 1-2 lub lis piam.

Nws yog ib qho tsim nyog yuav tsum tau noj cov tshuaj tom qab noj mov, raws li txwv tsis pub hypoglycemia yuav tshwm sim.

Cov tshuaj ua ke ntawm Amaryl M yuav tsum coj raws li tib lub ntsiab cai. Qhov ntau npaum ntawm cov tshuaj qhia ntawm cov tshuaj tau muab faib ua 2 zaug: thaum sawv ntxov thiab yav tsaus ntuj, lossis noj tam sim ntawd. Feem ntau, cov neeg mob raug pom zoo kom noj Amaril 2m + 500 mg.

Tus nqi ntawm Amaril los ntawm ntshav qab zib hauv cov neeg mob laus yog xaiv nrog kev ceev faj heev, thiab kev kho mob yog nqa nrog kev soj ntsuam tas li ntawm lub raum.

Cov ntaub ntawv tshuaj ntxiv

Thaum sau ntawv yuav ntawm Amaril lossis Amaril M, tus kws kho mob yuav tsum tsis tsuas yog muab lus qhia txog kev siv tshuaj kom raug, tab sis kuj tseem ceeb toom txog kev mob tshwm sim. Kev saib xyuas tshwj xeeb yuav tsum tau them rau qhov kev pheej hmoo ntawm cov ntshav qog ntshav qab zib, uas tuaj yeem txhim kho yog tias tus neeg mob tsis nco qab noj tam sim ntawd tom qab noj Amaril. Txhawm rau kom tsis txhob mob hypoglycemia, nws zoo dua yog tias muaj ncuav qab zib lossis khoom qab zib nrog koj.

Ntxiv nrog rau qib piam thaj thiab piam thaj hauv kev tso zis, tus neeg mob yuav tsum kuaj xyuas lub raum thiab lub siab ua haujlwm tsis tu ncua.

Ib qho lus nug ntau yog seb nws puas tuaj yeem haus dej cawv thaum kho mob nrog Amaril. Nws yog tsim nyog kom nco ntsoov tias cawv feem ntau ua tsis tau zoo thaum kho tus mob ntshav qab zib thiab tsis tuaj yeem sib xyaw nrog cov tshuaj feem ntau. Amaril kuj yog lawv li lawm. Qhov tshwm sim ntawm kev noj tshuaj thiab dej cawv tib lub sijhawm tuaj yeem tsis paub tseeb. Muaj qee kis, qhov kev ua haujlwm ntawm cov tshuaj tau nce siab dua, thiab hauv lwm qhov yog qhov txo qis. Yog li, thaum kho, koj yuav tsum tso tseg kev haus dej cawv thiab tshuaj yeeb muaj cawv.

Raws li rau kev sib cuam tshuam ntawm Amaril nrog lwm cov tshuaj, txhua yam ntawm no kuj yog nyob ntawm seb hom tshuaj. Noj qee yam tshuaj kho kom zoo dua ntawm kev ua haujlwm ntawm Amaril, lwm tus - txo qhov kev ua tau zoo. Daim ntawv ntawm ob qho tib si ntawd thiab lwm yam tshuaj muaj zog heev. Yog li, yog tias tsim nyog, noj lwm yam tshuaj, nws yog qhov yuav tsum tau qhia rau tus kws kho mob uas koom nrog txog txog kev kuaj mob thiab kev noj tshuaj. Hauv qhov no, tus kws kho mob yuav tuaj yeem xaiv cov tshuaj uas yuav tsis muaj lub txiaj ntsig tseem ceeb ntawm kev ua haujlwm ntawm Amaril.

Yog tias muaj kev mob tshwm sim, koj yuav tsum tsis txhob noj cov tshuaj thiab sab laj nrog kws kho mob.

Tsuas yog tus kws kho mob tuaj yeem pom zoo kom tsim nyog Amaril analogues.

Kev tshuaj xyuas txog cov tshuaj

Thaum lub sijhawm siv Amaryl rau cov ntshav qab zib hom 2, kev tshuaj xyuas tau txais txiaj ntsig zoo los ntawm ntau cov neeg mob. Qhov no lees tias qhov tseeb tias, nrog rau txoj kev muab tshuaj, cov tshuaj muaj tshuaj tiv thaiv hyperglycemia.

Ntxiv rau qhov kev ua tau zoo, ntau tus neeg yuav khoom hu ua xim sib txawv ntawm cov ntsiav tshuaj kom zoo tshuaj - qhov no yuav pab kom tsis meej cov tshuaj nrog qhov sib txawv ntawm cov tshuaj glimepiride.

Cov kev tshuaj xyuas tau txais ntawm Amaril paub tseeb tsis tsuas nws cov hauj lwm zoo, tab sis kuj tseem pom cov kev mob tshwm sim hauv cov lus qhia rau Amaril.

Feem ntau, cov neeg mob noj cov tshuaj qhia cov cim ntawm lub qog ntshav qab zib:

1. Neeg tsis muaj zog.
2. Qhuas.
3. Kev ntxhov siab thoob plaws lub cev.
4. Kiv taub hau
5. Muaj ntau yam qab los noj mov.

Feem ntau, raws li kev mob ntshav qab zib hauv ntshav qab zib mellitus, muaj kev phom sij ntawm kev tsis nco qab. Yog li, cov neeg uas coj Amaril yuav tsum tau nqa cov khoom muaj piam thaj tas li (piv txwv li, khoom qab zib) nrog lawv, yog li yog tias tsim nyog lawv tuaj yeem nce lawv cov suab thaj sai thiab txhim kho lawv cov kev noj qab haus huv. Txawm li cas los xij, raws li kws kho mob, kev hloov pauv hauv thaj chaw qab zib tsis yog qhov qhia tau rau qhov tsis muaj txiaj ntsig ntawm cov tshuaj. Thaum cov tsos mob zoo li no, nws txaus los kho lub koob tshuaj.

Ib qho teeb meem tshwm sim rau cov neeg tsav tsheb uas tau yuam kom cov neeg mob hypoglycemic yog qhov muaj kev tsis zoo thaum tsav tsheb. Cov kev mob tshwm sim zoo sib xws yog qhia hauv cov lus qhia hauv cov npe ntawm cov kev mob tshwm sim. Qhov kev txo qis hauv cov tshuaj tiv thaiv tau piav qhia los ntawm cov nyhuv ntawm glimepiride ntawm lub paj hlwb.

Ntawm cov neeg mob ntshav qab zib laus, hauv kev txheeb xyuas ntawm Amaril, ntau tus sau txog ib qho ntxiv tsis zoo: txawm hais tias qhov kev ua tau zoo uas Amaril txo qis qab zib, cov tshuaj mob ntshav qab zib yuav kim heev, vim tias cov tshuaj muaj peev xwm raug nqi ntau dua li qee yam tshuaj noj, suav nrog Lavxias. ntau lawm.

Nqe thiab analogues ntawm cov tshuaj

Koj tuaj yeem yuav Amaril nyob rau hauv cov chaw muag tshuaj hauv nroog tsis tu ncua, tab sis muaj ib lub caveat: nws tsis yog muag. Raws li rau ntau lwm cov tshuaj tiv thaiv kab mob, koj yuav tsum muab daim ntawv yuav tshuaj rau Amaryl noj.

Lwm lo lus nug nrov uas nyiam ntau tus mob ntshav qab zib yog Amaril raug nqi ntau npaum li cas. Tus nqi ntawm cov tshuaj hauv qhov no yuav yog nyob ntawm seb muaj pes tsawg ntawm cov ntsiav tshuaj hauv pob thiab qhov ntau npaum li cas ntawm cov tshuaj. Yog li, piv txwv li, ib pob ntawm cov tshuaj rau 30 ntsiav tshuaj tus nqi, nyob ntawm seb cov koob tshuaj, los ntawm 200 txog 850 rubles. Hauv qhov no, Amaril 1 mg raug tus nqi yog li ntawm 230-280 rubles, qhov ntim ntawm Amaril ntsiav tshuaj 2 mg - 450-560 rubles, 3 mg - rau 630-830 rubles. Cov ntsiav tshuaj uas kim tshaj plaws Amaril 4 mg 90 pcs. - lawv raug nqi qhov nruab nrab ntawm 870-1080 rubles.

Amaril M tuaj yeem muag rau 570-600 rubles. Nws yog ib qho tseem ceeb xav txog tias rau cov nqi zoo li no koj tuaj yeem yuav Amaril 2mg ntsiav tshuaj + 500 mg. Nws yog qhov nyuaj heev kom tau txais cov tshuaj qis dua (1 mg + 250), vim tias nws tau ntau tsawg los ntawm kws kho mob, thiab raws li, nws tsis tshua muaj muag.

Muaj ntau cov tshuaj ntawm cov yeeb yam zoo sib xws. Cov feem ntau cov analogues:

Piv txwv li, Amaril feem ntau hloov pauv nrog cov tshuaj Gliclazide (pln - Gliclazide). Nws tseem nyob nrog pawg sulfanylurea. Cov tshuaj muaj pes tsawg leeg suav nrog kev ua haujlwm nkaus xwb - gliclazide thiab cov tshuaj ntxiv. Cov tshuaj cuam tshuam rau beta hlwb, txhim kho insulin ntau lawm. Ntxiv rau, cov tshuaj pab nrog edema, vim nws txhim kho ntshav microcirculation, inhibits platelet adhesion, yog li txo txoj kev pheej hmoo ntawm thrombosis thiab lwm yam teeb meem.

Dab tsi cov tshuaj hypoglycemic zoo tshaj plaws yuav qhia tus kws tshaj lij hauv video hauv cov lus no.

Amaril cov tshuaj

Cov tshuaj yog zwm rau cov chaw kho mob thiab pharmacological pawg ntawm qhov ncauj hypoglycemic tshuaj ntawm peb tiam sulfonylurea. Amaryl muaj cov kev ua lub sijhawm ntev. Kev sib xyaw ua ke, nrog rau cov txiaj ntsig tseem ceeb ntawm kev ua antioxidant thiab cov nyhuv me me rau cov hlab plawv, ua rau muaj kev siv ntau ntawm cov tshuaj los tawm tsam tus mob ntshav qab zib hom 2 nrog qhov tsis muaj txiaj ntsig ntawm metformin monotherapy.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj tau nthuav tawm nyob rau hauv kev ua lag luam nyob rau hauv plaub qhov kev sib txawv ntawm kev tso tawm, txhua tus uas tau npaj rau kev kho mob ntshav qab zib, nyob ntawm tus neeg yam ntxwv ntawm tus neeg mob:

1. Amaryl, 1 mg: oblong liab ntsiav tshuaj ntawm daim ntawv tiaj, ntawm ob sab muaj qhov pheej hmoo txaus sib faib, tsab ntawv "xyob h"Thiab engraving" NMK ".
2. Amaril, 2 mg: oblong ntsuab ntsiav tshuaj tiaj tus zoo, ntawm ob sab muaj qhov pheej hmoo txaus sib faib, tsab ntawv "xyob h"Thiab engraving" NMM ".
3. Amaril, 3 mg: oblong daj daj cov ntsiav tshuaj yog ntsiav tshuaj ntawm daim ntawv tiaj, ntawm ob sab muaj qhov kev pheej hmoo sib faib, tsab ntawv "h" thiab sau "NMN".
4. Amaril, 4 mg: oblong xiav ntsiav tshuaj, tiaj tus kheej, ntawm ob sab muaj qhov pheej hmoo sib faib, tsab ntawv "h" thiab kos "NMO".

lactose monohydrate, sodium carboxymethyl hmoov txhuv nplej siab, povidone, microcrystalline cellulose, magnesium stearate, dyes liab thiab daj hlau oxide, indigo carmine

Tsuas tshuaj thiab tswj hwm

Amaryl noj thaum noj mov lossis ua ntej noj mov, ntxuav nrog kua. Nyob rau thawj theem ntawm kev nkag mus, muaj kev pheej hmoo ntawm hypoglycemia, yog li tus kws kho mob tswj tau yog qhov tsim nyog. Qhov koob tshuaj ntawm glimepiride yog txiav txim siab los ntawm cov txiaj ntsig ntawm kev txiav txim siab txog qib ntawm cov piam thaj hauv cov zis thiab ntshav. Kev txais tos yuav pib nrog ib ntsiav tshuaj (1 mg glimepiride) ib hnub. Ntxiv mus, thaum glycemic tswj kev tiv thaiv tsis muaj peev xwm pom, qhov ntau npaum nce mus txog 2 mg lossis ntau dua. Lub sijhawm nruab nrab ntawm kev nce ntxiv yog 1-2 lub lis piam. Qhov tshuaj ntau ntau yog 6 mg rau ib hnub. Kev sib xyaw ua ke nrog tshuaj insulin yog kho los ntawm kws kho mob nkaus xwb.

Cawv thiab Amaryl

Cov tshuaj muaj qhov cuam tshuam ncaj qha rau cov ntshav qab zib. Qhov kev ua no tau raug hloov kho tseem ceeb raws li kev haus cawv. Qhov ua rau lub ntsej muag tsis zoo tuaj yeem nce lossis txo qis, thiab nws nyuaj heev rau kev twv ua ntej cov txiaj ntsig, uas ua rau txwv tsis pub siv dej cawv thaum noj tshuaj.

Amaril qhov piv txwv

Cov tshuaj hloov pauv muaj xws li sulfonylurea-based tshuaj tiv thaiv ntshav qab zib hom 2. Cov qauv ntawm txhais tau tias:

• Glimepiride - tshuaj muaj tib lub npe qub,
• Diagninide - cov piam thaj txo cov tshuaj raws li cov tshuaj repaglinide,
• NovoNorm - ib qho tshuaj txawv teb, suav nrog repaglinide,
• Glidiab - tshuaj Lavxias raws li glimepiride,
• Ntshav qab zib yog cov tshuaj tuaj rau ntshav qab zib.

Amaril lossis Diabeton - uas yog ib qho zoo dua

Ob qho tshuaj no tau sau tseg rau hom 2 mob ntshav qab zib mellitus thiab muaj nyob hauv ntsiav tshuaj hom. Lawv li qub tsim tawm ntawm cov tshuaj insulin, ua kom cov nqaij mos rhiab ntau dua, txo cov roj (cholesterol) thiab qhov ntsuas ntawm lub sijhawm los ntawm kev noj mov mus rau tso tawm insulin. Yog tias tus neeg mob lub cev tsis zoo ua haujlwm, cov tshuaj txo qis cov protein nyob hauv cov zis. Qhov sib txawv ntawm cov tshuaj yog tus nqi - Diabeton yog pheej yig dua.