Reduxin® (Reduxin)

Reduxine muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav: qhov loj me No. 2, xiav thiab xiav, cov ntsiab lus yog xim dawb los yog dawb nrog lub plhaw daj ntawm cov hmoov (10 txhua tus hlwv, hauv ib pob duab los ntawm 3 lossis 6 pob).

Cov tshuaj uas muaj sia (hauv 1 tshuaj ntsiav):

• Microcrystalline cellulose - 158.5 mg lossis 153.5 mg,
• Sibutramine hydrochloride monohydrate - 10 mg lossis 15 mg.

Lub Cheebtsam ntu: calcium stearate.

Cov lus sib xyaw ntawm cov tshuaj plhaub: gelatin, zas titanium dioxide, zas xim xiav xiav, zas azorubine (tshuaj ntsiav 10 mg).

Cov Yuav Tsum Muaj

• Kev tswj tsis tau ntawm cov leeg ntshav (ntshav siab saum 145/90 hli Hg)
• Kab mob hauv lub plawv, mob hlab ntsha ib leeg txha muaj kab mob, tsis xwm yeem, mob tsis zoo ntawm lub plawv, tsis ua haujlwm rau lub plawv tsis ua haujlwm ntev, tachycardia, kab mob cerebrovascular (mob ntxiv cerebrovascular, mob hlab ntsha tawg),
• Kev ua tsis zoo rau lub raum thiab / lossis lub siab ua haujlwm,
• General zuam,
• Mob Mob
• Kev noj zaub mov kom hnyav (bulimia nervosa lossis anorexia),
• Benign prostatic hyperplasia
• Muaj cov organic ua rau kev rog (hypothyroidism, thiab lwm yam),
• Thyrotoxicosis,
• Lub ntsej muag kaw lub ntsej muag,
• Kws kho mob muab tshuaj, dej caw los yog tshuaj yaj yeeb,
• Pheochromocytoma,
• Siv tib lub tshuaj tiv thaiv kabmob, tshuaj tiv thaiv kev nyuaj siab thiab lwm yam tshuaj ua rau lub hauv nruab nrab cov hlab hlwb,
• Txheeb pom zoo siv lossis kev tswj hwm rau 2 lub lis piam ua ntej kev tswj hwm ntawm Reduxine rau monoamine oxidase inhibitors (xws li, ephedrine, ethylamphetamine, fenfluramine, phentermine, dexfenfluramine),
• Kev siv lwm yam tshuaj los txo qhov nruab nrab ntawm lub cev qhov hnyav, nrog rau cov tshuaj muaj tryptophan thiab tshuaj rau pw tsaug zog,
• Cov menyuam hnub nyoog qis dua 18 xyoo,
• Cev xeeb tub thiab lactation
• Lub hnub nyoog laus dua 65,
• Hypersensitivity rau ib yam ntawm cov tshuaj.

Tus txheeb ze (noj cov tshuaj nrog ceev faj):

• Arterial hypertension (keeb kwm thiab tswj hwm),
• Mob circulatory tsis ua hauj lwm,
• Keeb kwm ntawm arrhythmias,
• Kab mob rau cov hlab ntshav (nrog rau keeb kwm ntawm)
• Lub raum tsis zoo thiab / lossis lub siab ua haujlwm ntawm mob hnyav thiab mob hnyav,
• Cholelithiasis,
• Keeb kwm ntawm lus thiab lub cev muaj zog,
• Neurological ntshawv siab, suav nrog qaug dab peg thiab hlwb ruam (suav nrog hauv keeb kwm).

Tsuas tshuaj thiab tswj hwm

Reduxine tsiav tshuaj noj qhov ncauj ib zaug ib hnub, ua ntej noj mov lossis thaum noj mov. Cov tshuaj ntsiav tau nqos tag nrho thiab ntxuav nrog qhov dej txaus lossis lwm yam kua.

Cov koob tshuaj tau teeb tsa ib tus zuj zus thiab nyob ntawm qhov kam rau ua ntawm cov tshuaj thiab nws qhov kev ua haujlwm zoo. Thawj koob tshuaj feem ntau yog 10 mg. Yog tias cov tshuaj tsis raug txaus, koj tuaj yeem pib noj nrog 5 mg.

Nrog rau qhov txo hauv lub cev qhov hnyav los ntawm tsawg dua 5% nyob rau thawj lub hlis ntawm kev kho, qhov tshuaj ntawm lub cev tau nce ntxiv rau 15 mg ib hnub twg. Hauv cov neeg mob uas tsis poob 5% lossis ntau dua ntawm lawv thawj qhov hnyav tsis dhau 3 lub hlis, kev kho mob tau tso tseg. Txoj kev kho yuav tsum tsis txhob txuas ntxiv txawm tias, tom qab poob ceeb thawj, tus neeg mob rov ntxiv 3 kg lossis ntau dua.

Lub sijhawm tag nrho ntawm kev kho mob Reduxin tsis yog ntau tshaj 2 xyoos, vim tias tsis muaj ntaub ntawv qhia txog kev nyab xeeb thiab ua haujlwm ntawm cov tshuaj nrog kev kho ntev dua.

Kev kho yog nqa tawm los ntawm kev saib xyuas ntawm tus kws kho mob nrog cov kev paub dhau los hauv kev tiv thaiv kev rog. Txoj kev kho kom zoo yog pom zoo kom ua ke nrog kev tawm dag zog thiab kev noj haus.

Pharmacological pawg

Cov Tshuaj Hauv Tshuaj

Reduxin ® yog kev sib koom ua ke uas nws qhov kev ua yog vim nws cov khoom xyaw.

Sibutramine yog cov prodrug thiab exerts nws cov nyhuv hauv vivo vim muaj cov metabolites (amines thawj thiab theem nrab) uas inhibit reuptake ntawm monoamines (serotonin, norepinephrine thiab dopamine). Kev nce ntxiv ntawm cov ntsiab lus ntawm neurotransmitters hauv synapses nce kev ua si ntawm central 5-HT-serotonin thiab adrenergic receptors, uas ua rau muaj qhov nce ntawm satiety thiab txo qis ntawm kev thov khoom noj, nrog rau kev nce hauv thermal ntau lawm. Indirectly qhib beta ua₃-adrenoreceptors, sibutramine ua rau ntawm daim ntaub adipose xim av. Qhov txo qis hauv lub cev nyhav yog nrog los ntawm kev nce ntxiv hauv plasma concentration ntawm HDL thiab ib qho kev txo qis ntawm cov triglycerides, tag nrho cov roj cholesterol, LDL thiab uric acid. Sibutramine thiab nws cov metabolites tsis cuam tshuam rau qhov kev tso tawm ntawm monoamines, tsis inhibit MAO, muaj kev cuam tshuam qis rau ntau ntawm cov neurotransmitter receptors, suav nrog serotonin (5-HT₁5-NT_1A5-NT_1B5-NT_2C), adrenergic (beta₁-, beta₂-, beta₃-, Alpha₁-, Alpha₂-), dopamine (D₁, D₂), muscarinic, histamine (N₁), benzodiazepine thiab glutamate (NMDA) receptors.

MCC Nws yog ib qho enterosorbent, muaj cov yam ntxwv ua kom tu siab thiab muaj cov nyhuv hauv detoxification. Nws khi thiab tshem tawm ntau cov kab mob me me, cov khoom lag luam ntawm lawv cov kev ua haujlwm tseem ceeb, co toxins ntawm exogenous thiab endogenous xwm, kev ua xua, xenobiotics, thiab ntxiv rau qee yam dhau ntawm qee yam khoom hauv metabolic thiab metabolites lub luag haujlwm rau kev loj hlob ntawm endogenous toxicosis.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, nws nrawm los ntawm lub plab zom mov tsawg kawg 77%. Thaum lub sijhawm pib nkag los ntawm lub siab, nws hla cov kab mob biotransformation nyob rau hauv kev cuam tshuam ntawm CYP3A 4 isoenzyme nrog kev tsim ntawm ob lub cev ua haujlwm (metabolites) - monodesmethylsibutramine (M1) thiab didesmethylsibutramine (M2). Tom qab txhaj ib koob tshuaj 15 mg C_max hauv cov ntshav ntshav, M1 yog 4 ng / ml (3.2––8 ng / ml), M2 yog 6.4 ng / ml (5.6–7,2 ng / ml). C_max ua tiav tom qab 1.2 teev (sibutramine), 3-4 teev (M1 thiab M2). Concurrent Noj Lub Zog C_max metabolites los ntawm 30% thiab nce lub sijhawm mus cuag nws los ntawm 3 teev yam tsis hloov AUC. Nws yog sai faib rau ntawm ntaub. Kev sib txuas lus nrog cov protein yog 97 (sibutramine) thiab 94% (M1 thiab M2). C_ss nquag metabolites nyob rau hauv cov ntshav ntshav tau mus txog hauv 4 hnub tom qab pib siv thiab kwv yees li 2 lub sij hawm muaj siab nyob hauv cov ntshav ntshav tom qab noj ib koob. T_1/2 sibutramine - 1.1 teev, M1 - 14 teev, M2 - 16 teev .Txhais cov khoom siv tiv thaiv kab mob ua rau lub cev tsis ua haujlwm nrog rau kev ua kom lub cev tsis ua haujlwm, uas yog tawm ntawm lub raum.

Cov pab pawg neeg tshwj xeeb

Paul Tam sim no muaj tsawg cov ntaub ntawv tsis tau qhia tias muaj kev kuaj mob sib txawv hauv pharmacokinetics hauv cov txiv neej thiab poj niam.

Laus lub caij nyoog. Pharmacokinetics hauv cov laus neeg noj qab haus huv (hnub nyoog nruab nrab - 70 xyoo) zoo ib yam li cov hluas.

Tsis hlauv. Cov teeb meem tsis ua hauj lwm tsis muaj kev cuam tshuam rau AUC ntawm cov tshuaj metabolites M1 thiab M2, tshwj tsis yog rau metabolite M2 hauv cov neeg mob thaum kawg mob raum tsis ua haujlwm.

Daim siab ua haujlwm. Hauv cov neeg mob uas muaj lub siab tsis ua hauj lwm zoo tom qab siv ib koob sibutramine AUC, cov nquag metabolites M1 thiab M2 yog 24% ntau dua ntawm cov neeg muaj kev noj qab haus huv.

Cev xeeb tub thiab lactation

Txij li tam sim no tsis muaj qhov ntau ntawm cov kev tshawb fawb txog kev nyab xeeb ntawm cov teebmeem ntawm sibutramine ntawm tus menyuam, cov tshuaj no yog contraindicated thaum cev xeeb tub.

Cov poj niam uas muaj hnub nyoog deev yuav tsum siv tshuaj tiv thaiv thaum siv Reduxin ®.

Nws yog contraindicated mus noj Reduxin ® thaum pub niam mis.

Sab sij huam

Feem ntau, cov kev mob tshwm sim thaum pib kho mob (hauv thawj 4 lub lis piam). Lawv qhov mob hnyav thiab zaus ua haujlwm tsis muaj zog thaum sijhawm. Cov kev mob tshwm sim feem ntau me me thiab thim rov qab. Cov kev mob tshwm sim, nyob ntawm qhov ntxim rau cov plab hnyuv siab raum thiab lub nruab nrog cev, tau nthuav tawm raws li hauv qab no: ntau heev (≥10%), feem ntau (≥1%, tab sis lub hauv nruab nrab ntawm lub paj hlwb: ntau zaus - lub qhov ncauj qhuav thiab pw tsis tsaug zog, feem ntau - mob taub hau, kiv taub hau, ntxhov siab, mob caj dab, nrog rau kev hloov pauv hauv saj.

Los ntawm CCC: feem ntau - tachycardia, palpitations, nce ntshav siab, vasodilation.

Kev ntsuas ntshav nce ib nrab thaum so ntawm 1-3 hli Hg pom. thiab nce pes nrab ntawm lub plawv ntog los ntawm 3-7 yeej / min. Qee qhov xwm txheej, tshaj tawm cov ntshav siab thiab lub plawv dhia tsis suav nrog. Clinically kev hloov pauv siab ntawm ntshav siab thiab cov mem tes tau sau tseg feem ntau thaum pib kho mob (hauv thawj 4-8 lub lis piam).

Kev siv Reduxin ® hauv cov neeg mob ntshav siab: saib "Cov Lus Qhia Tsis Txaus Siab" thiab "Cov Lus Qhia Tshwj Xeeb".

Los ntawm lub plab zom mov: heev - tsis qab los noj mov thiab cem quav, ntau zaus - xeev siab thiab exacerbation ntawm hemorrhoids. Nrog rau qhov nyiam ua kom tawv ncauj thaum ntxov, tswj kev khiav haujlwm ntawm txoj hnyuv yog tsim nyog. Yog tias cem quav tshwm sim, tsum tsis txhob noj thiab noj tshuaj laxative.

Ntawm feem ntawm daim tawv nqaij: feem ntau - tawm hws.

Muaj qee zaus, kev kho mob sibutramine tau piav qhia yam tsis txaus ntseeg hauv qab no: kev ua rau lub plab, mob tawv nqaij, ua rau mob khaub thuas, ua pob khaus, tawv nqaij, mob nraub qaum, mob plab, tsis nco qab, nqhis dej, rhinitis, kev nyuaj siab, qaug zog, lub zog ua haujlwm, ntxhov siab, chim siab, tshee, mob interstitial mob nephritis, los ntshav, Shenlein-Genoch purpura (mob hauv daim tawv nqaij), ua kom mob huam, mob thiav, ua kom tsis muaj zog ntxiv hauv cov kev ua ntawm daim siab enzymes hauv cov ntshav.

Hauv chav kawm ntawm kev tshawb fawb tom qab muag kev tshaj tawm, cov kev tsis zoo ntxiv tau piav qhia, cov npe hauv qab, los ntawm cov kab ke hauv lub cev:

Los ntawm CCC: atrial fibrillation.

Los ntawm lub nruab zog: kev tsis haum lub cev (los ntawm kev tawm pob nyob rau hauv daim tawv nqaij thiab urticaria rau angioedema (Quincke's edema) thiab anaphylaxis).

Mob Hlwb: psychosis, lub xeev ntawm kev xav tua tus kheej, tua tus kheej thiab mania. Yog tias muaj cov xwm txheej zoo li no, cov tshuaj yuav tsum tau tsum txuas mus ntxiv.

Los ntawm lub paj hlwb: cramps, lub sij hawm luv luv nco tsis taus.

Los ntawm sab ntawm cov khoom ntawm lub zeem muag: qhov muag plooj (daim ntaub thaiv ua ntej lub qhov muag).

Los ntawm lub plab zom mov: raws plab, ntuav.

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: alopecia.

Los ntawm ob lub raum thiab mob txeeb zig: kev tso zis cia.

Los ntawm kev muaj me nyuam: ejaculation / orgasm cuam tshuam, impotence, coj khaub tsis xwm, poj niam los ntshav.

Kev sib txuam

Cov tshuaj tiv thaiv ntawm microsomal oxidation, suav nrog cov tshuaj tiv thaiv ntawm CYP3A 4 isoenzyme (suav nrog ketoconazole, erythromycin, cyclosporin) nce ntshav ntau ntawm sibutramine metabolites nrog rau kev nce siab hauv lub plawv thiab qhov nce ntawm qhov tsis txaus ntseeg hauv QT.

Rifampicin, tshuaj tua kab mob macrolide, phenytoin, carbamazepine, phenobarbital thiab dexamethasone tuaj yeem nrawm cov metabolism hauv sibutramine. Kev siv ib txhij ntawm ob peb yam tshuaj uas ua rau muaj cov serotonin ntau ntxiv hauv cov ntshav ntshav tuaj yeem ua rau qhov kev txhim kho muaj kev cuam tshuam loj. Muaj qee zaus, nrog rau kev siv ib txhij cov tshuaj Reduxin ® nrog SSRIs (tshuaj rau kev kho kev nyuaj siab), qee cov tshuaj rau kev kho mob migraine (sumatriptan, dihydroergotamine), muaj zog analgesics (pentazocine, pethidine, fentanyl) lossis tshuaj tiv thaiv kev tiv thaiv (dextromethorphan) tuaj yeem tsim kho. cov leeg serotonin.

Sibutramine tsis muaj kev cuam tshuam cov nyhuv ntawm qhov ncauj txwv tsis pub muaj.

Nrog rau kev coj ua ke ntawm sibutramine thiab haus dej cawv, tsis muaj ib qho nce ntawm cov cawv tsis zoo. Txawm li cas los xij, kev haus dej cawv tsis tau ua ke nrog cov kev pom zoo noj zaub mov zoo thaum noj sibutramine.

Nrog rau kev siv ua ke nrog lwm cov tshuaj nrog sibutramine uas cuam tshuam rau hemostasis lossis platelet muaj nuj nqi, kev pheej hmoo los ntshav ntau dua.

Cov tshuaj sib cuam tshuam nrog kev siv sibutramine tib lub sijhawm nrog cov tshuaj uas ua rau nce ntshav siab thiab lub plawv tam sim no tsis tau to taub. Pawg tshuaj no suav nrog cov tshuaj phom ntsig, tshuaj tiv thaiv, mob khaub thuas thiab tshuaj tiv thaiv kev ua xua, uas suav nrog ephedrine lossis pseudoephedrine. Yog li, thaum muaj kev sib txig nrog cov thawj coj ntawm cov tshuaj no nrog sibutramine, kev ceeb toom yuav tsum tau siv. Kev siv sibutramine nrog cov tshuaj kom txo lub cev qhov hnyav, ua rau lub nruab nrab ntawm lub paj hlwb, lossis siv yeeb tshuaj rau kev kho mob ntawm lub paj hlwb yog contraindicated.

Tsuas tshuaj thiab tswj hwm

Sab hauv Ib hnub ib zaug, thaum sawv ntxov, yam tsis ntxo thiab haus dej ntau (ib khob dej). Cov tshuaj muaj peev xwm nqa tau ob qho tib si ntawm lub plab khoob thiab ua ke nrog noj mov.

Cov koob tshuaj tau teeb tsa ib leeg zuj zus, nyob ntawm kev tiv taus siab thiab kev ua kom tau zoo hauv chaw kho mob. Qhov pom zoo kom pib noj yog 10 mg / hnub. Yog tias nyob rau 4 lub lis piam txij thaum pib kho, qhov kev txo lub cev qhov hnyav tsawg dua 2 kg tau tiav, tom qab ntawd cov koob tshuaj nce mus rau 15 mg / hnub.

Reduxin ux kev kho mob yuav tsum tsis pub ntev tshaj 3 lub hlis hauv cov neeg mob uas tsis teb zoo rau kev kho, i.e. uas tsis pub dhau 3 lub hlis ntawm kev kho mob tsis ua tiav qhov ua kom lub cev txo los ntawm 5% los ntawm qhov ntsuas pib. Kev kho yuav tsum tsis txhob txuas ntxiv yog tias, nrog kev kho ntxiv tom qab qhov ua tiav ntawm lub cev qhov hnyav, tus neeg mob lub cev qhov hnyav nce li 3 kg lossis ntau dua.

Lub sijhawm kho yuav tsum tsis pub ntau tshaj 1 xyoos, vim tias siv sijhawm ntev dua ntawm kev noj sibutramine, kev siv tau thiab cov ntaub ntawv muaj kev nyab xeeb tsis muaj.

Kev kho mob nrog Reduxine ® yuav tsum tau ua nrog rau kev noj haus thiab kev tawm dag zog hauv kev saib xyuas ntawm tus kws kho mob nrog cov kev paub dhau los hauv kev kho kev rog.

Noj ntau dhau

Cov tsos mob Nws tsis muaj cov pov thawj tsawg heev txog kev siv tshuaj sibutramine ntau dhau. Feem ntau cov kev phiv tshuaj uas cuam tshuam nrog kev noj ntau dua yog tachycardia, ntshav nce siab, mob taub hau, kiv taub hau. Tus neeg mob yuav tsum ceeb toom lawv tus kws kho mob yog tias xav tias tsam noj ntau dhau.

Kev Kho Mob: Tsis muaj kev kho tshwj xeeb lossis kev siv tshuaj tua tus kheej. Nws yog ib qho tsim nyog yuav tau ua cov kev ntsuas dav dav: kom ntseeg tau tias kev ua pa pub dawb, saib xyuas qhov xwm txheej ntawm CVS, thiab tseem, yog tias tsim nyog, nqa tawm cov kev txhawb nqa cov kev mob tshwm sim. Kev tswj hwm sijhawm kom ua haujlwm ntawm cov pa roj carbon ntau, nrog rau lub plab zom zaub mov, tuaj yeem txo qhov kom tsawg ntawm sibutramine hauv lub cev. Cov neeg mob uas muaj ntshav siab thiab tachycardia raug xaj-beta-blockers. Qhov ua tau zoo ntawm kev yuam diuresis lossis hemodialysis tseem tsis tau tsim.

Cov lus qhia tshwj xeeb

Kev kho mob nrog Reduxine ® yuav tsum tau ua raws li ib feem ntawm txoj kev kho mob rau cov neeg yuag yuag raws li kev saib xyuas ntawm tus kws kho mob nrog cov kev paub dhau los kho kev rog.

Cov kev kho nyuaj nyuaj siab suav nrog ob qho tib si kev hloov pauv ntawm kev noj zaub mov zoo thiab kev ua neej, thiab kev ua si lub cev ntau ntxiv.

Ib qho tseem ceeb ntawm kev kho yog kev tsim ua ntej rau kev hloov mus tsis tu ncua kev noj zaub mov noj thiab kev ua neej, uas tsim nyog los tswj kev ua kom tiav hauv kev txo lub cev hnyav txawm tias tom qab kev siv tshuaj txiav tawm. Raws li ib feem ntawm kev kho mob nrog Reduxin ®, cov neeg mob yuav tsum hloov pauv lawv lub neej thiab kev coj noj coj ua kom tom qab kev kho tiav tiav lawv paub tseeb tias qhov ua tiav ntawm kev txo lub cev nyhav tau raug tswj cia.

Cov neeg mob yuav tsum nkag siab meej tias kev tsis ua raws li cov kev cai no yuav ua rau nce lub cev hnyav dua thiab rov mus ntsib tus kws kho mob uas koom nrog.

Hauv cov neeg mob noj Reduxin ®, nws yog qhov tsim nyog los ntsuas theem ntawm cov ntshav siab thiab lub plawv dhia. Hauv thawj 3 lub hlis ntawm kev kho mob, cov kev ntsuas no yuav tsum tau soj ntsuam txhua 2 asthiv, thiab tom qab ntawd txhua hli. Yog tias thaum kuaj ob zaug sib law liag nce lub plawv dhia thaum so ≥10 neeg ntaus / min lossis CAD / DBP ≥10 hli Hg kuaj pom , koj yuav tsum tsum tsis kho. Cov neeg mob nrog kev mob ntshav siab, hauv tus neeg, tawm tsam keeb kwm ntawm kev tiv thaiv qog ntshav, ntshav siab yog siab dua 145/90 hli Hg. , kev tswj hwm no yuav tsum tau nqa tawm tshwj xeeb tshaj yog thiab, yog tias tsim nyog, ntawm cov sijhawm luv. Cov neeg mob uas cov ntshav siab ob zaug thaum ntsuas ntsuas ntau dhau qib ntawm 145/90 hli Hg. , kev kho mob nrog Reduxine ® yuav tsum tau tshem tawm (saib. "Kev mob tshwm sim").

Hauv cov neeg mob uas pw tsaug zog apnea syndrome, nws yog ib qho tsim nyog yuav tau ua tib zoo saib xyuas ntshav siab.

Kev saib xyuas tshwj xeeb yuav tsum tau tswj hwm kev siv tshuaj ib txhij uas nce QT luv. Cov tshuaj no suav cov tshuaj histamine H blockers.₁receptors (astemizole, terfenadine), tshuaj antiarrhythmic uas nce QT ntu sij hawm (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), mob plab hnyuv kom muaj zog cisapride, pimozide, sertindole thiab tricyclic antidepressants. Qhov no kuj tseem siv tau rau cov xwm txheej uas tuaj yeem ua rau qhov nce QT luv (hypokalemia thiab hypomagnesemia - saib "Kev cuam tshuam").

Lub sijhawm nruab nrab ntawm qhov kom tsawg ntawm MAO inhibitors (suav nrog furazolidone, procarbazine, selegiline) thiab cov tshuaj Reduxin ® yuav tsum yog tsawg kawg 2 lub lis piam.

Txawm hais tias tsis muaj kev sib txuas tau tsim los ntawm kev noj Reduxin ® thiab kev txhim kho ntawm thawj lub ntsws ntsig, txawm li cas los xij, muab cov kev paub txog kev pheej hmoo rau cov pab pawg no, nrog kev soj ntsuam mob niaj zaus, tshwj xeeb yuav tsum them rau cov tsos mob xws li mob ntxiv (mob ntsws tsis ua haujlwm), mob hauv siab thiab o ntawm ob txhais ceg Cov.

Yog tias koj hla lub koob tshuaj Reduxin ®, koj yuav tsum tsis txhob noj ob npaug ntawm cov tshuaj hauv koob tshuaj tom ntej, nws raug nquahu kom koj yuav tsum noj cov tshuaj ntxiv raws li lub sijhawm tau teev tseg.

Lub sijhawm noj Reduxin ® yuav tsum tsis pub tshaj 1 xyoos.

Nrog rau kev siv sibutramine thiab lwm yam SSRIs, muaj kev pheej hmoo los ntshav ntau ntxiv. Hauv cov neeg mob predisposed los ntshav, nrog rau kev noj tshuaj uas cuam tshuam hemostasis lossis platelet muaj nuj nqi, sibutramine yuav tsum siv nrog ceev faj.

Txawm hais tias cov ntaub ntawv tshawb fawb txog kev quav tshuaj rau sibutramine tsis muaj, nws yuav tsum paub tseeb tias puas muaj qee yam kev quav yeeb tshuaj hauv tus neeg mob keeb kwm thiab mob siab rau qhov tshwm sim ntawm kev siv tshuaj yeeb.

Sibutramine belongs rau Daim Ntawv teev cov muaj hwj chim, tau pom zoo los ntawm tsab cai ntawm tsoomfwv Lavxias lub Xeev thaum lub Kaum Ob Hlis 29, 2007 No. 964.

Muaj feem xyuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem. Kev Siv Reduxine ® tej zaum yuav txwv koj lub peev xwm tsav tsheb thiab siv tshuab ua haujlwm. Thaum lub sijhawm siv cov tshuaj Reduxin ®, kev saib xyuas yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm cov kev phom sij uas yuav tsum muaj kev xav ntau ntxiv thiab ceev ntawm cov kev tiv thaiv psychomotor.

Chaw tsim tshuaj paus

LLC "Ozone". 445351, Russia, Samara Cheeb Tsam, Zhigulevsk, ul. Xuab zeb, 11.

Tel./fax: (84862) 3-41-09.

Tsoomfwv Meskas Lub Tsev Haujlwm Tsis Koom Tes "Moscow Endocrine Cog". 109052, Moscow, st. Novokhokhlovskaya, 25.

Tel./fax: (495) 678-00-50 / 911-42-10.

Chaw nyob thiab naj npawb xov tooj ntawm cov koom haum muaj cai rau kev sib tiv tauj (tsis txaus siab thiab tsis txaus siab): LLC PROMOMED RUS 105005, Russia, Moscow, ul. Malaya Pochtovaya, 2/2, p. 1, pom. 1, chav nyob 2.

Xov Tooj: (495) 640-25-28.

Yeeb tshuaj sib cuam tshuam

Erythromycin, ketoconazole thiab cyclosporine nce ntxiv ntshav plasma concentration ntawm sibutramine metabolites nrog kev nce siab hauv lub plawv thiab qhov chaw kuaj mob tsis tseem ceeb ntawm QT luv.

Phenytoin, rifampicin, phenobarbital, carbamazepine, dexamethasone, thiab tshuaj tua kab mob macrolide tuaj yeem nrawm Reduxin metabolism.

Nrog rau kev siv ib txhij nrog hwj chim analgesics (pethidine, pentazocine, fentanyl), qee cov tshuaj rau kev kho mob ntawm migraine (dihydroergotamine, sumatriptan), tshuaj tiv thaiv kab mob (dextromethorphan) thiab tshuaj rau kev kho mob kev nyuaj siab, hauv qee yam mob tsawg, kev txhim kho serotonin syndrome tuaj yeem tau.

Reduxin tsis muaj kev cuam tshuam cov nyhuv ntawm qhov ncauj txwv tsis pub muaj.

Nrog rau kev tswj hwm ua ke nrog ethanol, qhov nce ntawm qhov tshwm sim tsis zoo ntawm tom kawg tsis tau sau tseg. Txawm li cas los xij, cawv yog qhov cuam tshuam nrog kev noj zaub mov kom zoo thaum lub sijhawm kho.

Kev ntsuas rau siv

Reduxin yog tshuaj rau qhov hnyav poob hauv lub xub ntiag ntawm cov mob hauv qab no:

• Kev rog rog Alimentary nrog lub cev qhov hnyav (BMI) ntawm 27 kg / m 2 lossis ntau dua ua ke nrog lwm cov kev pheej hmoo uas cuam tshuam nrog kev rog dhau (qhov tsis yog insulin-tiv thaiv ntshav qab zib mellitus, dyslipoproteinemia),
• Alimentary rog nrog BMI ntawm 30 kg / m 2 lossis ntau dua.

Cov lus qhia rau kev siv Reduxin: txoj kev thiab qhov ntau npaum li cas

Reduxine yuav tsum noj qhov ncauj ib hnub ib zaug, thaum sawv ntxov, nqos cov tsiav tshuaj tag nrho thiab haus nrog qhov muaj kua txaus, rau ntawm lub plab khoob lossis thaum noj mov.

Qhov pom zoo kom pib noj yog 10 mg. Yog tias nyob rau 4 lub lis piam nws tsis tuaj yeem ua tiav qhov txo hauv lub cev qhov tsawg kawg ntawm 5%, qhov koob tshuaj txhua hnub yog nce rau 15 mg.

Lub sijhawm tag nrho ntawm kev kho mob yuav tsum tsis pub tshaj 2 xyoos (vim tias tsis muaj ntaub ntawv qhia txog kev nyab xeeb thiab ua haujlwm ntawm kev siv sibutramine ntev dua).

Yog tias nyob hauv 3 lub hlis tsis muaj qhov txo lub cev qhov hnyav los ntawm tsawg kawg 5% ntawm thawj qhov hnyav, Reduxine tau raug tshem tawm. Kev kho yuav tsum tsis txhob txuas ntxiv yog tias, nrog kev siv tshuaj ntxiv, tus neeg mob ntxiv 3 kg lossis ntau dua hauv qhov hnyav.