Tsifran ": cov lus qhia rau kev siv, ntsuas thiab contraindications

Cifran yog tshuaj tua kab mob uas tsim los ntawm ib qho ntawm Is Nrias teb cov chaw muag tshuaj loj tshaj plaws, Ranbaxy Laboratories Ltd.

Cov tshuaj nquag siv ntawm Cifran yog ciprofloxacin hydrochloride (sib npaug rau 500 mg ciprofloxacin), uas yog siv los kho kab mob hauv lub cev.

Pharmacological kev txiav txim:

Ciprofloxacin belongs rau ib pawg tshuaj uas hu ua quinolones / fluoroquinolones. Lawv inhibit qhov kev tso zis ntawm DNA thiab inhibit DNA gyrase hauv cov kab mob rhiab, pab txhawb rau "kev rhuav tshem" ntawm ob-xaim DNA. Cov tshuaj lom nyob hauv nplooj siab, ib nrab-lub neej: (hauv cov menyuam yaus), (rau cov laus). Kev zam: tso zis quav

Cov lus qhia siv rau cov laus:

mob voos
Cov mob ENT
mob hniav thiab flux (yog kawm),
mob typhoid fever los ntawm tus mob salmonella,
gonorrhea
mob qhov muag
tuberculosis
cov kab mob zawv plab los ntawm Escherichia coli, Campylobacter Euni lossis ntau yam mob Shigella,
mob raum
kab mob prostatitis,
sepsis
kis kab mob ntawm cov pob qij txha thiab pob txha tshwm sim los ntawm enterobacter cloaca, kev faib tawm ntawm marcescens lossis Pseudomonas aeruginosa,
cov ntaub so ntswg mos thiab cov qauv tawv nqaij,
anthrax.

Kev ntsuas rau kev siv "Tsifran" rau menyuam:

Kev kho thiab tiv thaiv anthrax.
Cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa hauv cov menyuam yaus hnub nyoog 5 txog 17 xyoo nrog cystic fibrosis (cystic fibrosis) ntawm lub ntsws.

"Tsifran" yog muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab-cov ntsiav tshuaj hauv qhov ntau npaum ntawm 250 mg thiab 500 mg, ua cov kua muag thiab hauv txoj hauv kev ua kom pom tseeb.

"Tsifran": cov lus qhia rau kev siv thaum cev xeeb tub thiab lactation

Feem ntau cov kev tshawb fawb tsis pom muaj kev pheej hmoo ntawm kev tsis txaus siab thaum yug los thaum cov poj niam siv ciprofloxacin lossis lwm yam tshuaj tua kabmob quinolone / fluoroquinolone thaum thawj lub sijhawm cev xeeb tub. Txij li cov kev tshawb fawb no suav nrog feem ntau cov poj niam noj ciprofloxacin, tsuas yog qhov tshwm sim ntawm kev siv Cifran ntev ntev tsis paub. Txawm li cas los xij, tsis muaj kev pheej hmoo ntawm kev yug menyuam ntawm cov menyuam mos liab uas raug rau lub sijhawm ntev dua ntawm kev siv ciprofloxacin.

Tsuas yog tus kws kho mob poj niam ua rau pom tus poj niam thaum cev xeeb tub thiab lactation tuaj yeem txiav txim siab seb cov txiaj ntsig ntawm Cyfran rau leej niam yeej dhau qhov kev pheej hmoo ntawm cov tshuaj rau cov menyuam hauv plab.

Ntau qhov phiv tuaj yeem cuam tshuam nrog kev siv Cyfran. Cov feem ntau tsis xws li:

xeev siab
mob taub hau
ua pob
daim tawv liab liab (tshwj xeeb tshaj yog thaum raug lub hnub). Nws raug nquahu kom siv cov tshuaj pleev thaiv hnub thaum mus nraum zoov tom qab noj "Tsifran"
nws yog xim hlau ci hauv qhov ncauj
ntuav
mob plab
zawv plab

Cov kev mob tshwm sim loj dua (tsis tshua muaj, tab sis tsis suav):

Cramps.
Tsaus muag.
Cov tawv nqaij ua pob.
Kev puas tsuaj rau lub siab, uas pom los ntawm cov tsos mob hauv qab no: daj ntseg (daj ntseg ntawm daim tawv nqaij thiab lub qhov muag), tso zis tsaus nti, xeev siab, ntuav, tsis qab los noj mov, mob rau ntawm lub plab mog sab xis.
Tendon edema, tshwj xeeb tshaj yog nyob rau cov poj niam hnub nyoog 60 xyoo. Edema, nyeg, tsub kom qhov feem ntau ntawm kev sib tawg ntawm cov leeg thaum ua haujlwm lub cev. Tendon edema tuaj yeem tshwm sim ntau lub hlis tom qab siv Cyfran raug txiav.
Txawm hais tias Cifran siv los kho cov mob los ntawm kev muaj cov qe ntshav dawb tsawg, nws tuaj yeem txo nws cov qe ntshav dawb hauv lub cev. Qhov no ua rau lub cev tsis muaj zog tiv thaiv kev tiv thaiv, thiab tseem ua rau muaj kev cuam tshuam ntau dua ntawm cov neeg mob kom kis tau tus mob.
Photosensitivity (txawv txav siab rhiab rau lub hnub ci).
Cov tsos mob hnyav zuj zus hauv cov neeg mob lub siab mob hlwb. Qhov no tuaj yeem ua rau xav txog kev tua tus kheej.

Cov Tshuaj Tiv Thaiv:

Kev fab rau ciprofloxacin.
Myasthenia gravis (kab mob autoimmune ntawm lub zog neuromuscular).
Tshuaj qaug dab peg
Kab mob plawv.
Raum los yog mob rau daim siab.

Nws yuav tsum tsis txhob xyaw nrog cov tshuaj hauv qab no:

"Tizanidine" - siv los kho cov leeg nqaij. Kev Hem: qhov kev pheej hmoo ntawm cov kev mob tshwm sim hauv cov lus piav qhia ntawm "Tsifran" (cov lus qhia rau kev siv) nce.
"Warfarin" yog cov tshuaj siv rau hauv kev kho mob los ntshav tsis haum. Kev Hem Neeg: muaj feem yuav los ntshav.
"Theophylline" - siv los qhib cov hlab cua hauv kev kho mob hawb pob. Kev Hem: siv tib lub sijhawm los ntawm "Theophylline" thiab "Tsifran" tuaj yeem ua rau qhov tsis haum, nrog rau qhov ua txhaum ntawm lub plawv atherosclerosis.
Sildenafil ("Viagra") yog ib qho yeeb tshuaj siv hauv kev kho mob ntawm kev kho erectile kawg. Kev hem thawj: nce qib ntawm sildenafil hauv ntshav, qhov tshwm sim ntawm kev mob tshwm sim ntawm Viagra yog qhov yuav tshwm sim.
"Pentoxifylline-Teva" - siv los txhawm rau txhim kho kev mob peripheral. Kev hem thawj: cov theem ntawm cov tshuaj no hauv cov ntshav nce siab thiab qhov kev pheej hmoo ntawm phiv ntau ntxiv.
"Omeprazole" yog ib yam tshuaj uas siv los tua Helicobacter pylori thiab kho tus mob gastroesophageal reflux tus kab mob. Kev hem thawj: qib ntawm "Tsifran" hauv cov ntshav txo qis, yog li ua rau cov hauj lwm tsis zoo ntawm cov tshuaj no.
Cov calcium, magnesium lossis hlau npaj (suav nrog hauv cov tshuaj uas ua rau tua cov ntsiav tshuaj). Kev Hem: qhov ua haujlwm ntawm Tsifran txo qis.
Antacids yog cov tshuaj uas ua rau cov kua qaub hauv lub plab. Kev hem thawj: qhov ua tau zoo ntawm “Tsifran.
Cov ntsiav tshuaj Cifran tuaj yeem ua rau muaj kev cuam tshuam ntawm kev xav ntawm caffeine.

Cov neeg mob uas tseem tab tom phais (suav nrog kev phais hniav) yuav tsum ceeb toom tus kws phais neeg lossis tus kws tshuaj kom loog txog kev noj Cifran. Cov tshuaj no yuav cuam tshuam rau lwm cov tshuaj uas siv thaum phais mob.

Txawm hais tias qhov tseeb tias cov tshuaj feem ntau siv rau qee cov kab mob, nws tsis yog ib txwm ua tau zoo, thiab yog li nws tseem ceeb uas kws kho mob sau ntawv rau kev ntsuam xyuas los txiav txim siab qhov tsim nyog ntawm kev sau ntawv ntawm Cyfran. Cov lus qhia rau kev siv tsis suav nrog ntau yam ntawm kev ntsuas, tab sis kuj muaj ntau qhov sib txuam, yog li tsis txhob siv tshuaj rau nws tus kheej.

Yuav noj "Tsifran" nrog mob prostatitis thiab lwm yam kab mob

Hmoov tsis zoo, nws tau ua haujlwm me me tawm tsam anaerobic cov kab mob (chlamydia thiab mycoplasma), uas tso cai rau pathogens tsim lawv tus kheej hauv prostate, thiab rov ua cov chav kawm ntawm Cyphran kwv yees poob thiab lub sijhawm kho mob tsis muaj nqi.

Rau cov neeg laus uas muaj cov tsos mob tshwm sim ntawm tus kab mob prostatitis, Cifran ntsiav tshuaj feem ntau yog tshuaj ntawm 500 mg ob zaug ib hnub rau ob mus rau plaub lub lis piam. Txawm li cas los xij, cov lus qhia meej rau yuav ua li cas coj "Tsifran" rau tus neeg mob yuav muab los ntawm tus kws kho mob urologist raws qhov mob hnyav ntawm tus kab mob.

Kev tshawb fawb hauv Kaus Lim Qab Teb tau qhia tias kev sib xyaw ntawm qej thiab ciprofloxacin zoo dua rau ciprofloxacin ib leeg rau kev kho tus mob prostatitis. Cov kws tshawb nrhiav tau soj ntsuam cov tshuaj antimicrobial thiab anti-inflammatory yam khoom ntawm qej, nrog rau cov nyhuv ntawm qej, nrog rau ciprofloxacin hauv cov txiv neej laus ua nrog cov kab mob prostatitis.

Tag nrho ntawm 41 nas tsuag nrog tus kabmob no tau raug xaiv rau plaub pawg kho mob: tswj, qij, uas tau txais ciprofloxacin nkaus xwb, thiab tau txais qej ntxiv nrog ciprofloxacin. Tom qab peb lub lis piam ntawm kev kho mob, cov nas hauv cov pab pawg qej tau muaj kev poob qis ntawm cov kab mob loj hlob thiab muaj kev txhim kho hauv cov tsos mob ntawm tus mob prostate piv nrog pawg tswj hwm. Txawm li cas los xij, hauv pab pawg tau muab qej ntxiv nrog ciprofloxacin, muaj qhov kev txo qis ntawm cov kab mob loj hlob thiab qhov kev txhim kho tseem ceeb hauv cov tsos mob ntawm tus mob prostate piv nrog cov pab kho nrog ciprofloxacin.

Cov txiaj ntsig tau hais tias qej tuaj yeem muab cov txiaj ntsig antimicrobial thiab anti-inflammatory, nrog rau cov txiaj ntsig ua ke nrog ciprofloxacin.

Cov neeg mob uas mob prostatitis noj Cifran feem ntau yws cov kev mob tshwm sim xws li xeev siab (2.5%), raws plab (1.6%), ntuav (1%), thiab tawm pob (1%).

Yuav ua li cas noj "Tsifran" qhov ncauj:

Qhov pom zoo ntawm cov neeg laus thaj tsam li ntawm 250 mg txog 750 mg ob zaug ib hnub. Ua raws li hom kev kis kab mob uas yuav kho, koj yuav tsum noj Cifran li 3 txog 28 hnub.
Nrog rau cov cystitis tsis yooj yim, kev kho mob hauv chav kawm ntev li 3 hnub, nrog cov qauv hnyav lossis mob hnyav
Nrog rau qhov mob txhab ntshav, txoj kev kho mob ntev li ntawm 8 txog 10 hnub.
Nrog otitis media, tonsillitis, tonsillitis, chav kawm ntawm kev kho mob yog, nruab nrab, 5 hnub.
Yog hais tias mob voos, nyob ntawm qhov mob hnyav, txoj kev kho mob yuav siv sijhawm 7 txog 28 hnub.
Lub chav kawm ntawm kev kho mob "Tsifranom" mob txeeb zig
Nrog rau cov pob txha thiab mob pob txha, nws yuav tsim nyog noj "Tsifran" kom txog li ntau lub hlis.
Cov ntsiav tshuaj yuav tsum tsis yog zom, lawv muaj qhov tsis zoo siab.
Cov tshuaj Cifran tuaj yeem noj nrog zaub mov lossis ntawm lub plab khoob.
Txawm hais tias ciprofloxacin tuaj yeem noj nrog zaub mov uas muaj cov khoom noj siv mis, koj yuav tsum tsis txhob noj cov tshuaj ib leeg nrog mis lossis nrog cov khoom noj uas muaj calcium.
Koj tsis tuaj yeem siv tshuaj antacids, tshuaj ntxiv nrog calcium, magnesium, iron lossis multivitamins 6 teev ua ntej lossis 2 teev tom qab noj "Tsifran".

Yuav ua li cas noj "Tsifran" tso ntshav:

Cov txheej txheem qauv ntawm kev kho mob infusion (kev kho mob nrog kev daws tshuaj) "Tsifran" hauv kev mob hnyav
Tso ncaj qha, "Tsifran" raug tswj hwm hauv lub sijhawm luv (ntawm 30 feeb mus rau ib teev).
Tsifran infusion muaj 0.9% w / v sodium tshuaj dawb tov.
Txoj kev lis ntshav yog sib xws nrog txhua yam kua dej ntawm lub cev.

"Tsifran": ntau npaum cov neeg laus thiab menyuam yaus, tus nqi thiab analogues ntawm cov tshuaj

Lub sijhawm ntawm kev kho mob thiab koob tshuaj Cyfran yuav nce raws li hom ntawm cov kab mob.

Qhov ntau npaum ntawm cov kws kho mob sau yuav siv txawv ntawm qhov qhia hauv kab lus.

Ua raws li tus kws kho mob pom zoo.

"Tsifran": noj rau cov laus:

Mob hnyav (mob me los sis mob hnyav): 500 mg ob zaug ib hnub lossis 400 mg ob zaug ib hnub infusion (tso ntshav) rau 10 hnub. Los ntawm qhov ncauj infusion txoj kev siv "Tsifran" txawv nyob rau hauv uas cov tshuaj yog muab los ntawm ib tug neeg tawm.
Mob pob txha thiab mob sib kis (mob sib khuav lossis nruab nrab): 500 mg ob zaug ib hnub lossis 400 mg Txoj kev lis ntshav ib hnub ob zaug rau 30 hnub.
Cov kab mob ua rau mob prostatitis (mob me lossis mob pesnrab). Kev noj tshuaj yog qhia rau cov kab mob ntev rau prostatitis los ntawm Escherichia coli lossis Proteus Mirabilis: 500 mg ob zaug ib hnub lossis 400 mg infusion ob zaug ib hnub rau 28 hnub.
Cov mob otitis ntev: 500 mg ob zaug ib hnub lossis 400 mg infusion ib hnub ob zaug rau
Kev kis mob zawv plab: 500 mg ob zaug ib hnub rau
Cov kab mob ua pa qis dua (mob me lossis hnyav): 500 mg ob zaug ib hnub lossis 400 mg Txoj kev lis ntshav ib hnub ob zaug rau ib lossis ob lub lis piam.
Kev kis mob ntawm tus qauv ntawm daim tawv nqaij (mob me lossis hauv nruab nrab): 500 mg ob zaug ib hnub lossis 400 mg txhaj tshuaj ob zaug ib hnub rau ib lossis ob lub lis piam.
Cov mob txeeb zig (mob hnyav / tsis yooj yim): 250 mg ob zaug ib hnub twg rau 3 hnub.
Kev mob urethral thiab gonococcal (tsis yooj yim dua): ib zaug.
Anthrax, postexposure kev kho thiab prophylaxis: 500 mg ob zaug ib hnub lossis 400 mg infusion hauv ib hnub rau 60 hnub.

Cov neeg laus uas muaj hnub nyoog yog tau txhaj tshuaj tsawg dua ntawm Cyfran ntsiav tshuaj. Kev noj tshuaj yog xam raws qhov mob hnyav ntawm cov tsos mob thiab cov tsos mob ntawm tus kab mob, nrog rau kev tshem tawm creatinine. Piv txwv, yog tias qhov ntsuas no yog los ntawm 30 txog 50 ml / min, koob tshuaj Cyfran yog li ntawm 250 txog 500 mg ob zaug ib hnub.

"Tsifran" tsis yog thawj qhov kev xaiv hauv kev kho menyuam yaus (tshwj tsis yog anthrax), vim muaj qhov nce ntxiv ntawm cov kev mob tshwm sim (suav nrog arthropathy) piv nrog pawg tswj hwm. Tsis muaj ntaub ntawv teev tshuaj rau cov neeg mob raum tsis zoo.

"Tsifran": ntau npaum cov me nyuam 5 txog 17 xyoo:

Mob ntsws pulmonary anthrax (kev kho mob postexposure).
Kev daws rau kev lis ntshav: ntawm tus nqi ntawm 10 mg / kg, ob zaug ib hnub, rau ob hlis. Ib koob tshuaj ib tus neeg yuav tsum tsis pub ntau tshaj 400 mg.
Cov ntsiav tshuaj: ntawm tus nqi ntawm 15 mg / kg, ob zaug ib hnub rau ob hlis, koob tshuaj rau ib tug neeg yuav tsum tsis pub ntau tshaj 500 mg.
Cystic fibrosis.
Ntsiav tshuaj: ntawm tus nqi ntawm 40 mg / kg / hnub, ob zaug ib hnub. Ib koob tshuaj ib leeg yuav tsum tsis pub ntau tshaj 2 g / hnub.
Tshuaj rau kev lis ntshav: kg / hnub, txhua 8 teev. Ib koob tshuaj ib leeg yuav tsum tsis pub ntau tshaj 1.2 g / hnub.

Kev noj tshuaj ntau dhau ntawm ciprofloxacin tuaj yeem ua rau lub raum puas tsuaj.

Hauv kev tshawb nrhiav tsiaj, kev noj tshuaj ciprofloxacin ntau heev ua rau muaj teeb meem ua pa, ntuav, thiab ua kom mob hlwb.

Cov lus qhia ntawm "Tsifran":

Tshuaj Baycip - 500 mg. Chaw Tsim Tshuaj - Bayer.
Cebran ntsiav tshuaj - 500 mg. Chaw Tsim Tshuaj - Xiav Corss.
Ciplox ntsiav tshuaj - 500 mg. Chaw Tsim Tshuaj - Cipla.
Ciprowin ntsiav tshuaj - 500 mg. Chaw Tsim Tshuaj - Alembic Pharma.
Alcipro ntsiav tshuaj - 500 mg. Chaw tsim tshuaj paus - Alkem Labs.
Cipronat ntsiav tshuaj - 500 mg. Chaw Tsim Tshuaj - Natco Pharma.
Ciprofen ntsiav tshuaj - 500 mg. Chaw tsim tshuaj paus - Franklin Labs.
Ciprobid Cov ntsiav tshuaj - 500 mg. Chaw Tsim Tshuaj - Cadila Pharma.
Cov Ntsaws Tshuaj Quintor - 500 mg. Chaw Tsim Tshuaj - Torrent Pharma.
Ncos pob ntseg thiab qhov muag "Betaciprol" - 0.3%. Chaw Tsim Tshuaj - Beta Lek.
Ificipro Txoj kev lis ntshav kua - 2 mg / ml. Chaw tsim tshuaj paus - chaw kuaj mob UNIQUE chaw soj nstuam.

Tus nqi ntawm "Tsifran" hauv ntau lub tsev muag tshuaj nyob hauv Russia txawv ntawm 51 rubles (rau 10 ntsiav tshuaj ntawm 250 mg txhua tus) txog 92 rubles (rau cov ntsiav tshuaj nrog ntau npaum li 500 mg txhua).

Tus nqi ntawm "Tsifran" hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj yog los ntawm 44 txog 56 rubles.

Tus nqi ntawm "Tsifran" hauv daim ntawv ntawm lub ntsiab muag muag yog li ntawm 48 txog 60 rubles.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dosage daim ntawv tso tawm Tsifran ST - cov ntsiav tshuaj coated: ntsiav tshuaj 250 mg + 300 mg - daj, daj, ntsiav tshuaj forte 500 mg + 600 mg - daj, oval, ntawm ib sab nrog cov kab sib faib (hauv kab ntawv qhwv ntawm 1, 2 lossis 10 blisters) 10 pcs.).

Yam tshuaj muaj nyob hauv 1 ntsiav tshuaj:

ciprofloxacin - 250 lossis 500 mg (raws li hydrochloride monohydrate),
Tinidazole BP - 300 lossis 600 mg.

tub ntxhais: sodium lauryl sulfate, sodium hmoov txhuv nplej glycolate, microcrystalline cellulose, anhydrous colloidal silicon, magnesium stearate,
cov khoom xyaw ntawm cov txheej txheej sab nrauv ntawm cov granules: sodium starch glycolate, purified talc, sodium lauryl sulfate, microcrystalline cellulose, anhydrous colloidal silicon, magnesium stearate,
lub plhaub: daj ntseg qhib, dej lim.

Cov Tshuaj Hauv Tshuaj

Cifran ST yog ib qho kev npaj ua ke uas muaj cov tshuaj ua haujlwm - tinidazole thiab ciprofloxacin - yog siv rau hauv kev kho mob kis mob los ntawm aerobic thiab anaerobic microorganisms.

Cov khoom tseem ceeb ntawm cov khoom siv tsis tu ncua:

Cov Tshuaj Pharmacokinetics

Cov tshuaj yeeb dej caw yog nqus tau zoo nyob rau hauv txoj hnyuv plab. Qhov ntau ntau (C_max) txhua qhov ntawm cov khoom tiav tau tiav hauv 1-2 teev.

Bioavailability yog 100%, khi rau cov protein ntshav yog li 12%. Kev tshem tawm ib nrab-lub neej yog nyob ntawm thaj tsam li 12 txog 14 teev.

Nws sai sai nkag mus rau cov ntaub so ntswg ntawm lub cev thiab ncav cuag lub siab nyob rau ntawd.Nws nkag mus rau hauv cov kua roj cerebrospinal hauv ib qho kev sib luag uas yog sib npaug ntawm nws cov ntshav plasma concentration, yauv yauv rov qab nqus rau hauv lub plab hlaus.

Nws yog tawm hauv cov kua tsib hauv cov ntsiab lus me ntsis qis dua 50% ntawm nws cov ntshav dej hauv cov ntshav. Kwv yees li 25% ntawm cov koob tshuaj uas tau noj yog tawm los ntawm ob lub raum tsis hloov pauv. Tinidazole metabolites suav txog 12% ntawm kev siv tshuaj; lawv kuj tau tso tawm los ntawm lub raum. Ntxiv rau, qee qhov me me ntawm tinidazole yog tshem tawm los ntawm kev mob plab.

Ciprofloxacin

Tom qab lub qhov ncauj tswj hwm, nws yog qhov zoo yaim. Bioavailability yog kwv yees li 70%. Nrog rau kev siv ua ke nrog cov khoom noj, kev nqus ntawm cov khoom nkag mus qeeb dua. Ntawm 20 thiab 40% ntawm ciprofloxacin khi rau cov ntshav muaj protein ntau.

Nws nkag mus zoo rau cov dej hauv lub cev thiab cov nqaij - tawv nqaij, lub ntsws, rog, pob txha mos, pob txha thiab cov leeg nqaij, thiab ntxiv rau cov kabmob ntawm cov genitourinary system, nrog rau lub caj pas prostate. Cov ntsiab lus siab ntawm ciprofloxacin yog pom nyob hauv cov qaub ncaug, bronchi, hnoos qeev, lymph, peritoneal kua, kua dej ua kua, thiab kua tsib.

Ciprofloxacin yog kho qee qhov mob siab los ntawm daim siab. Kwv yees li 50% ntawm koob tshuaj yog tawm los ntawm lub raum tsis hloov pauv, 15% - nyob rau hauv daim ntawv ntawm kev siv cov khoom noj tshwj xeeb, tshwj xeeb, oxociprofloxacin. Qhov seem ntawm cov koob tshuaj tau tawm hauv cov kua tsib, qee ntu reabsorbed. Los ntawm kev mob plab hnyuv, 15 mus rau 30% ntawm ciprofloxacin yog tawm hauv. Ib nrab-lub neej yog kwv yees li 3.5-4.5 teev.

Hauv cov neeg mob laus thiab lub raum tsis ua haujlwm, lub sijhawm ib nrab yuav ntev dua.

Kev ntsuas rau siv

Raws li cov lus qhia, Tsifran ST raug tshuaj rau kev kho mob ntawm cov kab mob sib xyaw ua ke hauv qab no los ntawm cov kab mob siab-zoo / gram-tsis zoo, nyob rau hauv kev sib txuas nrog cov kab mob anaerobic thiab aerobic thiab / lossis protozoa:

Cov mob ENT: mob rau cov hlab ntshav, mob otitis media, tonsillitis, pharyngitis, mastoiditis, mob rau sab hauv ntej, mob ntsws,
cov tawv nqaij / cov nqaij mos mos ua mob: mob txhab, mob txhab rau daim tawv nqaij mob caj pas, mob caj dab, txaj txaj, mob qog nqaij hlav, hlawv, phlegmon,
kis kab mob ntawm qhov ncauj kab noj hniav: periostitis, periodontitis, mob gceivitis ulcerative,
kev kis mob ntawm lub plab mog thiab plab hnyuv siab raum, nrog rau kev sib xyaw nrog tus mob trichomoniasis: salpingitis, tubular ua mob, pelvioperitonitis, oophoritis, endometritis, prostatitis,
kis kab mob ntawm cov pob txha thiab pob qij txha: txha txha caj qaum, mob leeg txha caj qaum,
mob plab hnyuv: shigellosis, typhoid fever, amoebiasis,
mob txeeb zig thiab mob raum: cystitis, pyelonephritis,
ua mob sib kis mob plab,
qis cov kab mob ua pa: mob hnyav thiab mob ntsws ntev (thaum exacerbation) mob ntsws, mob ntsws, mob ntsws, mob ntsws,
lub sijhawm tom qab phais kev kho mob (tiv thaiv kev kis kab mob).

Cov Yuav Tsum Tau Ua

ntshav kab mob, inhibition ntawm cov hlwb pob txha hematopoiesis,
organic txhab ntawm lub paj hlwb,
mob siab rau plooj (porphyria)
lactose intolerance, lactase deficiency, qabzib-galactose malabsorption,
kev sib xyaw ua ke nrog kev kho mob tizanidine (cuam tshuam nrog qhov yuav tshwm sim ntawm kev txo qis hauv cov ntshav siab thiab kev txhim kho kev qaug zog loj),
hnub nyoog txog 18 xyoo
cev xeeb tub thiab lactation,
ib tug neeg tsis kam txais rau cov tshuaj, nrog rau lwm cov fluoroquinolones thiab imidazoles.

Tus Txheeb Ze (Tsifran ST raug tsa los ntawm kev saib xyuas mob):

cerebrovascular kev huam yuaj,
mob leeg nrog kev kho fluoroquinolone dhau los,
mob hlwb txha hnyav heev
mob plawv (myocardial infarction, plawv nres, bradycardia),
yug los ntev ntawm QT luv,
electrolyte tsis txaus, suav nrog hypokalemia, hypomagnesemia,
kev mob hlwb
mob raum / mob siab,
qaug dab peg, mob vwm.
kev siv tshuaj ua ke nrog cov tshuaj uas txuas ntxiv QT ntu, nrog rau cov tshuaj tiv thaiv kab mob ntawm cov chav kawm IA thiab III,
kev sib txuas ua ke nrog kev siv tshuaj tiv thaiv ntawm CYP4501A2 isoenzymes, suav nrog theophylline, methylxanthine, caffeine, duloxetine, clozapine,
hnub nyoog siab heev.

Cov lus qhia rau kev siv Tsifran ST: txoj kev thiab ntau npaum li cas

Cifran ST yog noj ntawm qhov ncauj nrog qhov dej txaus, nyiam dua tom qab noj mov. Zom, so, lossis lwm yam rhuav tshem cov ntsiav tshuaj yuav tsum tsis txhob.

Pom zoo rau cov neeg noj tshuaj ntawm Tsifran ST:

250 mg + 300 mg: 2 ntsiav tshuaj 2 zaug hauv ib hnub,
500 mg + 600 mg: 2 zaug ib hnub rau 1 ntsiav tshuaj.

Sab sij huam

cov hlab ntsha hauv lub cev: mob siab, mob taub hau, kiv taub hau, ua tsis tau zoo ntawm kev txav (nrog rau cov neeg hauv lub cev), dysesthesia, hypesthesia, hyperesthesia, paresthesia, tsis meej pem, gait cuam tshuam, dysarthria, nkees nkees ntau dua, ua tsis taus pa, tshee, tsis muaj zog, peripheral neuropathy, insomnia, tsis meej pem, npau suav phem, ntxiv intracranial siab, cerebral leeg leeg thrombosis, tsaus muag, mob taub hau, ntxhov siab, ntxhov siab vim, kev nyuaj siab, hnov qab, zoo li lwm yam kev puas siab puas ntsws. th (qee zaum hloov mus rau cov xwm txheej uas tus neeg mob yuav ua mob nws tus kheej), polyneuropathy, peripheral paralgesia,
lub plab zom mov: poob qab los noj mov, xerostomia, xim hlau tsis txaus hauv lub qhov ncauj, mob plab, xeev siab, raws plab, ntuav, pancreatitis, hepatonecrosis, mob siab, mob plab, cholestatic jaundice (tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob siab dhau los),
kev mob plawv: txo cov ntshav siab, lub plawv dhia tsis xws luag, tachycardia, txuas ntxiv ntawm QT ntu ntawm ib qho electrocardiogram, ventricular arrhythmias (suav nrog pirouette hom),
hematopoietic system: granulocytopenia, leukocytosis, mob ntshav hauv ntshav, hemolytic anemia, neutropenia, agranulocytosis, vasodilation, pancytopenia, inhibition ntawm cov pob txha mob hematopoiesis, thrombocytosis, thrombocytopenia, leukopenia, ntshav tsis txaus,
hnov cov khoom hauv nruab nrog cev: hnov tsis hnov tsw / saj, tinnitus, hnov lus / tsis hnov, qhov muag tsis pom kev (hauv daim ntawv ntawm daim ntawv pov thawj, kev hloov pauv ntawm qhov pom xim, nce hauv qhov pom kev)
cov kab mob ua pa: cov pa ua tsis taus pa (suav nrog bronchospasm),
cov kab mob hauv lub raum: tso zis cia, polyuria, lub raum tsis ua haujlwm, interstitial nephritis, hematuria, muaj cov kab mob nitrogen excretory ua haujlwm ntawm lub raum, crystalluria (nrog rau kev tso zis zis thiab alkaline zis), glomerulonephritis, dysuria,
musculoskeletal system: exacerbation ntawm cov tsos mob ntawm myasthenia gravis, nce nqaij mob nqaij, leeg pob txha caj dab, mob caj dab, txha caj qaum, mob caj dab, mob caj dab, myalgia, leeg tsis muaj zog,
kev kuaj ntsuas: hypercreatininemia, hyperglycemia, hyperbilirubinemia, hypoprothrombinemia, kev ua si ntawm amylase, alkaline phosphatase, mob hepatic transaminases,
kev ua xua: urticaria, pruritus, tsim cov hlwv, uas yog nrog los ntshav, thiab cov hnoos me me uas tom qab ntawd ua rau mob tawv nqaij, txhaws qhov ntswg rau ntawm daim tawv nqaij (petechiae), tshuaj ua npaws, mob ntsws / ntsej muag, ua tsis taus pa, vasculitis, eosinophilia, erythema nodosum, lom epidermal necrolysis (Lyell's syndrome), erythema multiforme exudative (suav nrog Stevens-Johnson syndrome), anaphylactic ceeb, anaphylactic kev hloov,
lwm tus: ua tawm hws ntau, tso dej tawm ntawm lub ntsej muag, asthenia, superinfection (suav nrog pseudomembranous colitis, candidiasis).

Noj ntau dhau

Tsis muaj ib qho tshuaj tua kab mob tshwj xeeb, yog li ntawd, thaum muaj kev noj ntau dhau, kev kho mob tshwm sim, nrog rau cov kev ntsuas nram qab no: mob plab zom mov lossis ntxias kom ntuav tawm, ntsuas kom muaj dej txaus hauv lub cev (kho kev kho mob), thiab txhawb kev kho mob.

Nrog kev pab ntawm hemo- lossis peritoneal dialysis, tinidazole tuaj yeem tshem tawm tag nrho los ntawm lub cev, ciprofloxacin hauv ib qho me me (kwv yees li 10%).

Cov lus qhia tshwj xeeb

Thaum lub sijhawm kho, ntev npaum li cas yuav tsum tiv thaiv lub hnub ci, vim tias muaj kev cuam tshuam ntawm kev thaij duab phototoxicity. Thaum lawv zoo li, Tsifran ST yog tam sim ntawd tso tseg.

Txhawm rau txo qhov ntxim nyiam ntawm crystalluria, nws yog tsis yooj yim sua kom dhau qhov kev pom zoo txhua hnub. Tsis tas li, tus neeg mob yuav tsum ua kom lub cev muaj dej txaus thiab kev tswj hwm ntawm cov kua qaub tso tawm kom ntwm mus. Kev noj cov tshuaj ua rau cov zis tsaus ntuj.

Muaj qee zaus, nyob rau lub sijhawm kho, kev txhim kho ntawm cov kev tsis sib xws xws li cov kab mob urticaria, txo qis ntshav siab, o ntawm lub ntsej muag / larynx, dyspnea thiab bronchospasm yog sau tseg. Yog tias koj muaj kev fab tshuaj rau ib qho imidazole derivative, hla kev hnov mob rau tinidazole tej zaum yuav tshwm sim, cov tsos mob ntawm tus ntoo khaub thuas thim rov qab rau ciprofloxacin kuj tseem tuaj yeem pom hauv cov neeg mob ua xua rau lwm cov fluoroquinolone derivatives. Yog li, hauv qee kis uas tus neeg mob tau sau tseg txog kev txhim kho kev tsis haum tshuaj rau cov tshuaj uas zoo sib xws, ib qho yuav tsum ua tib zoo suav nrog qhov muaj feem tshwm sim ntawm kev tsis haum tshuaj rau Cyfran ST.

Thaum lub sij hawm kho, nws yog ib qhov tsim nyog los saib xyuas daim duab ntawm cov ntshav peripheral.

Kev sib xyaw ua ke ntawm Cifran ST nrog cawv yog contraindicated, vim hais tias nrog kev sib xyaw ntawm tinidazole thiab cawv, mob plab hauv plab, ntuav, thiab xeev siab tuaj yeem tsim kho.

Tawm tsam cov keeb kwm yav dhau los ntawm tus mob vwm, lub keeb kwm mob nyhav ntawm qaug dab peg, kab mob vog thiab cov organic hlwb puas, Tsifran ST tuaj yeem siv rau kev noj qab haus huv, uas cuam tshuam nrog kev hem thawj ntawm cov kev phiv tshuaj los ntawm lub hauv nruab nrab lub paj hlwb.

Qhov ua tau zoo / kev nyab xeeb ntawm kev siv Tsifran ST rau kev kho thiab tiv thaiv tus mob anaerobic rau cov menyuam yaus uas tsis tau muaj 12 xyoos tsis tau tsim.

Yog tias mob raws plab thiab mob ntev dhau los ua rau lub sijhawm / tom qab kev kho mob, pseudomembranous colitis yuav tsum tau tshem tawm, uas yuav tsum tau tshem tawm sai ntawm cov tshuaj thiab kev teem caij kho kom tsim nyog.

Nyob rau hauv kev muaj mob ntawm cov leeg lossis cov tsos ntawm pom thawj cov tsos mob ntawm tus mob raum raum, qhov kev coj ntawm Cyfran ST tau tso tseg.

Yeeb tshuaj sib cuam tshuam

kev tiv thaiv kabmob tsis tau txais txiaj ntsig: lawv cov txiaj ntsig ua kom zoo dua qub, txhawm rau txhawm rau txhawm los ntshav, cov koob tshuaj raug txo qis li 50%,
ethanol: nws cov nyhuv yog txhim kho, tej zaum kev txhim kho ntawm disulfiram-zoo li cov tshuaj tiv thaiv,
ethionamide: kev sib xyaw tsis pom zoo,
phenobarbital: cov metabolism hauv ntawm tinidazole yog nrawm.

Tinidazole tuaj yeem siv nrog kev sib xyaw nrog sulfonamides thiab tshuaj tua kab mob (erythromycin, aminoglycosides, rifampicin, cephalosporins).

Chaw tsim tshuaj paus

Cov khoom xyaw nquag: ciprofloxacin hydrochloride 297.07 mg, sib npaug rau ciprofloxacin 250 mg.

Cov Cim: microcrystalline cellulose 25.04 mg, pob kws hmoov txhuv nplej siab 18.31 mg, magnesium stearate 3.74 mg, huv si talc 2.28 mg, colloidal anhydrous silicon 4.68 mg, sodium starch glycolate 23.88 mg, dej ntshiab * q.s.

Cov khoom siv zaj duab xis: Opadray-OY-S58910 dawb 13.44 mg, purified talc 1.22 mg, purified talc q.s., cov dej lim.

Pharmacological kev txiav txim

Tsifran - broad-spectrum antibacterial, bactericidal, antibacterial.

Nws thaiv cov kab mob DNA gyrase thiab cuam tshuam kev ua ke ntawm cov kab mob DNA, uas ua rau cov kab mob tuag.

Kev nqus tau sai sai los ntawm kev mob plab, qhov ncauj ua kom lub cev muaj peev xwm txog 70%. Tom qab txhaj ib koob ntawm 250 thiab 500 mg, qhov nruab nrab siab tshaj qhov nruab nrab yog 1.5 thiab 2.5 μg / L, raws, thiab ntau zaus dhau MPC90 rau feem ntau cov kab mob me. Tom qab kev tswj hwm ntawm 200 mg, qhov ntsuas ntshav yog 3.8 μg / ml. Tusyees faib thiab ncav cuag kev kho mob feem ntau hauv cov nqaij thiab dej ntau. Qib ntawm cov protein khi tau yog tsawg (19-40%). Nws yog tawm tsis pauv nrog tso zis, nrog rau cov kua tsib thiab cov quav.

Cov kab mob txeeb zig, kab mob gonorrhea, mob ntsws, mob rau daim tawv thiab cov nqaij mos ua mob, pob txha thiab sib kis, mob plab hnyuv, barley, mob ntshav lom.

Kev sib txuam

Nrog rau kev siv ua ke nrog didanosine nrog ciprofloxacin, cov nyhuv ntawm ciprofloxacin raug txo qis vim yog kev tsim cov txheej txheem nyuaj ntawm ciprofloxacin nrog rau txhuas thiab ntsev ntsev uas muaj nyob hauv didanosine.

Kev tswj hwm tib lub sijhawm ntawm ciprofloxacin nrog theophylline tuaj yeem ua rau nce theophylline concentration hauv cov ntshav ntshav vim kev sib tw inhibition nyob rau hauv cov chaw ntawm cytochrome P450 kev khi, uas ua rau muaj kev nce ntxiv hauv ib nrab ntawm lub neej ntawm theophylline thiab nce ntxiv ntawm kev pheej hmoo ntawm cov tshuaj lom cuam tshuam nrog theophylline.

Kev tswj hwm tib lub sijhawm ua tiav ntawm cov tshuaj ua tsis tau zoo, tshuaj tiv thaiv kab mob, tshuaj uas muaj lub peev xwm loj (piv txwv, cov tshuaj tiv thaiv kab mob), nrog rau cov tshuaj muaj txhuas, zinc, hlau lossis magnesium ions, tuaj yeem ua rau txo qis ntawm kev nqus ntawm ciprofloxacin, yog li ciprofloxacin yuav tsum noj ib qho 1-2 teev ua ntej lossis 4 teev tom qab siv cov tshuaj no.

Qhov kev txwv no tsis siv rau antacids uas yog rau chav kawm ntawm H2 receptor blockers.

Kev siv ua ke nrog ciprofloxacin, khoom noj siv mis los ua dej qab zib (xws li mis nyuj, kua mis nyeem qaub, kua txiv muaj kua txiv kab ntxwv) yuav tsum zam, vim tias kev nqus ntawm ciprofloxacin tuaj yeem txo qis. Txawm li cas los xij, calcium, uas yog ib feem ntawm lwm cov zaub mov, tsis cuam tshuam loj heev rau kev nqus ntawm ciprofloxacin.

Nrog rau kev siv ua ke ntawm ciprofloxacin thiab omeprazole, qhov txo qis me ntsis hauv qhov siab tshaj plaws (Cmax) ntawm cov tshuaj hauv cov ntshav ntshav thiab txo qis hauv thaj chaw hauv qab qhov nkhaus-sijhawm nkhaus (AUC) tuaj yeem sau tseg.

Kev sib xyaw ntawm ntau qhov ntau ntawm cov tshuaj ntawm quinolones (gyrase inhibitors) thiab qee cov tshuaj tsis haum steroidal (tsis suav nrog acetylsalicylic acid) tuaj yeem ua rau qaug dab peg.

Nrog rau kev siv ciprofloxacin thiab cov tshuaj tiv thaiv kab mob ib ce (suav nrog warfarin), lub sijhawm ua los ntshav lengthens.

Nrog rau kev siv txaws ciprofloxacin thiab cyclosporine, cov nyhuv nephrotoxic ntawm tom kawg tau txhim kho. Nrog rau kev kho kom zoo ib txhij nrog ciprofloxacin thiab cyclosporine, lub sijhawm luv luv nce ntawm plasma creatinine concentration tau pom. Hauv cov xwm txheej zoo li no, nws yog qhov tsim nyog los txiav txim siab qhov concentration ntawm creatinine hauv cov ntshav ob zaug ib lim tiam.

Qee qhov xwm txheej, tib lub sijhawm siv ciprofloxacin thiab glibenclamide tuaj yeem txhim kho cov txiaj ntsig ntawm glibenclamide (hypoglycemia).

Kev tswj hwm ntawm cov tshuaj uricosuric, suav nrog probenecid, ua rau qeeb tus nqi ntawm ciprofloxacin tshem tawm los ntawm ob lub raum (nce txog 59%) thiab nce qhov kev txiav txim siab ntawm ciprofloxacin hauv cov ntshav ntshav.

Nrog rau kev tswj hwm ciprofloxacin tib lub sijhawm, kev thauj mus los tubular (cov roj ntsha hauv lub raum) ntawm methotrexate tuaj yeem ua rau qeeb, uas tej zaum yuav muaj nrog kev nce ntxiv hauv cov concentration ntawm methotrexate hauv ntshav ntshav. Hauv qhov no, qhov ntxim nyiam ntawm cov kev mob tshwm sim ntawm methotrexate yuav nce ntxiv. Hauv qhov no, cov neeg mob tau txais kev kho ua ke nrog methotrexate thiab ciprofloxacin yuav tsum tau saib xyuas kom zoo.

Metoclopramide nrawm nrawm rau qhov nqus ntawm ciprofloxacin, txo lub sijhawm tsim nyog kom ua tiav nws cov kev xav ntau hauv cov ntshav ntshav. Hauv qhov no, txoj kev noj qab haus huv ntawm ciprofloxacin tsis hloov pauv.

Raws li kev tshawb fawb soj ntsuam nrog cov neeg ua haujlwm noj qab haus huv zoo nrog kev siv ciprofloxacin thiab tizanidine tib lub sijhawm, kev nce siab ntawm tizanidine hauv cov ntshav ntshav tau tshaj tawm: kev nce hauv Cmax los ntawm 7 zaug (ntawm 4 txog 21 zaug), nce AUC los ntawm 10 zaug (ntawm 6 txog 24 zaug). Nrog rau kev nce siab ntawm tizanidine nyob rau hauv cov ntshav cov ntshav, hypotensive thiab sedative phiv cuam tshuam yog txuam. Yog li, tib lub sijhawm siv cov ciprofloxacin thiab tizanidine yog contraindicated.

Ciprofloxacin tuaj yeem siv ua ke nrog lwm cov tshuaj tua kab mob.Raws li pom nyob rau hauv kev tshawb fawb hauv vitro, kev sib xyaw ua ke ntawm kev siv tshuaj ciprofloxacin thiab antibiotics-lactam, thiab aminoglycosides, tau nrog los ntawm kev siv tshuaj tiv thaiv tsis zoo thiab tsis zoo, qhov nce ntawm kev cuam tshuam ntawm ob qho tshuaj kuj tsis tshua muaj, thiab tsis tshua muaj qhov ua kom tsis muaj zog.

Yuav ua li cas coj, chav kawm ntawm kev tswj hwm thiab ntau npaum li cas

Sab hauv, ntawm lub plab zom mov, tsis suav zom, nrog me me ntawm kua. Thov suav daws noj yam tsis xav noj mov. Yog tias cov tshuaj siv rau ntawm lub plab khoob, cov tshuaj ua kom muaj zog yuav nqus tau sai dua. Hauv qhov no, cov ntsiav tshuaj yuav tsum tsis txhob muab ntxhua nrog cov khoom noj siv mis los ua kom muaj rog ntxiv (piv txwv li mis nyuj, kua mis nyeem qaub, kua txiv uas muaj calcium ntau cov ntsiab lus). Cov calcium uas pom hauv cov zaub mov ib txwm tsis cuam tshuam rau kev nqus ntawm ciprofloxacin.

Cov koob tshuaj ciprofloxacin nyob ntawm qhov mob hnyav, hom mob, tus mob lub cev, hnub nyoog, qhov hnyav thiab lub raum kev ua haujlwm ntawm tus neeg mob. Koob tshuaj pom zoo:

Kev kis mob ntawm txoj hlab ntsws qis (mob thiab mob ntev (hauv qib mob hnyav) mob ntsws, mob ntsws, ntsws, bronchiectasis, mob sib kis mob cystic fibrosis) mob me mus rau mob hnyav - 500 mg 2 zaug hauv ib hnub, muaj mob hnyav - 750 mg 2 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 7-14 hnub.

Kev kis mob ntawm LOP plab hnyuv siab raum (otitis media, mob siab mob ntsws) - 500 mg 2 zaug hauv ib hnub, kev kho mob yog 10 hnub.

Kev kis mob ntawm cov pob txha thiab pob qij txha (osteomyelitis, mob pob txha caj dab) - mob sib khuav mus rau mob hnyav - 500 mg 2 zaug ib hnub, muaj mob hnyav - 750 mg 2 zaug. Lub sij hawm ntawm kev kho mob yog txog li 4-6 lub lis piam.

Kev kis mob ntawm daim tawv nqaij thiab cov nqaij mos (mob nqaij, mob, kub hnyiab, ua qog, phlegmon) ntawm mob me mus rau mob hnyav - 500 mg 2 zaug hauv ib hnub, muaj mob hnyav - 750 mg 2 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 7-14 hnub.

Campylobacteriosis, shigellosis, raws plab "ntawm neeg ncig teb chaw" - 500 mg 2 zaug hauv ib hnub, kev kho mob yog 5-7 hnub.

Tus mob kub cev typhoid fever - 500 mg 2 zaug hauv ib hnub rau 10 hnub.

Nyuaj nyob rau hauv plab mob plab (ua ke nrog metronidazole) - 500 mg 2 zaug hauv ib hnub rau 7-14 hnub.

Kev kis mob ntawm lub raum thiab mob txeeb zig (cystitis, pyelonephritis) - 250 mg, nyuaj - 500 mg 2 zaug ib hnub. Lub chav kawm ntawm kev kho mob yog 7-14 hnub. Cystitis tsis mob nyob rau hauv cov poj niam - 250 mg 2 zaug ib hnub twg rau 3 hnub.

Kev tsis haum xeeb cov kab mob gonorrhea - 250-500 mg ib zaug.

Cov kab mob prostatitis mob ntev - 500 mg 2 zaug hauv ib hnub, chav kho mob - 28 hnub.

Lwm yam mob (saib ntu "Kev qhia") - 500 mg 2 zaug ib hnub. Septicemia, peritonitis (tshwj xeeb tshaj yog muaj mob sib kis nrog Pseudomonas, Staphylococcus lossis Streptococcus) - 750 mg 2 zaug ib hnub.

Kev tiv thaiv thiab kho mob ntsig txog mob ntsws anthrax - 500 mg 2 zaug hauv ib hnub rau 60 hnub.

Hauv kev kho mob ntawm cov neeg mob laus, cov koob tshuaj qis tshaj plaws ntawm ciprofloxacin yuav tsum siv, raws li kev mob hnyav thiab muaj cov cim tshem tawm (piv txwv, nrog kev tsim tawm ntawm 30 mus rau 50 ml / min, koob tshuaj pom zoo ntawm ciprofloxacin yog 250-500 mg txhua 12 teev).

Txog kev kho mob ntawm kev mob ntsig ntsig ntawm txoj hlab ntsws cystic fibrosis tshwm sim los ntawm Pseudomonas aeruginosa hauv cov menyuam hnub nyoog 5 txog 17 xyoo, 20 mg / kg ntawm lub cev hnyav tau raug hais lub ncauj 2 zaug / hnub. (ntau kawg koob 1500 mg). Lub sijhawm tiv thaiv yog 10-14 hnub.

Txog kev tiv thaiv thiab kho mob ntsig txog mob ntsws, 15 mg / kg lub cev hnyav 2 zaug / hnub yog tau noj ntawm qhov ncauj (qhov siab tshaj plaws ib zaug yuav tsum tsis pub tshaj - 500 mg thiab koob tshuaj txhua hnub - 1000 mg).

Kev noj cov tshuaj yuav tsum pib tam sim ntawd tom qab kev iab liam los yog paub tseeb tias muaj mob.

Lub sijhawm tag nrho ntawm ciprofloxacin nyob rau hauv daim ntawv pulmonary ntawm anthrax yog 60 hnub.

Cov lus qhia tshwj xeeb

Nws tau pom tias ciprofloxacin, zoo li lwm yam tshuaj ntawm chav kawm no, ua rau mob caj dab ntawm cov pob qij txha loj hauv cov tsiaj. Thaum txheeb xyuas cov ntaub ntawv kev nyab xeeb tam sim no ntawm kev siv ciprofloxacin hauv cov menyuam yaus hnub nyoog qis dua 18 xyoo, feem ntau ntawm cov mob ntsws cystic, tsis muaj kev sib txuas ntawm kev puas tsuaj rau pob txha mos lossis pob qij txha nrog kev noj tshuaj. mob ntsws (hauv cov menyuam yaus hnub nyoog 5 txog 17 xyoo) cuam tshuam nrog kev mob Pseudomonas aeruginosa thiab rau kev kho thiab tiv thaiv tus mob ntsws anthrax (tom qab xav tias yog lossis kis tau tus kabmob) Bacillus anthracis).

Hauv kev kho mob sab nrauv rau cov neeg mob ntsws uas yog mob los ntawm cov kab mob ntawm lub genus Pneumococcus, ciprofloxacin yuav tsum tsis txhob siv cov tshuaj ntawm thawj qhov kev xaiv.

Muaj qee kis, muaj qhov tshwm sim tsis zoo los ntawm lub hauv nruab nrab cov hlab ntsha tuaj yeem tshwm sim tom qab siv thawj zaug ntawm cov tshuaj. Nyob rau hauv tsawg zaus, psychosis tuaj yeem tshwm sim nws tus kheej hauv kev tua tus kheej. Hauv cov xwm txheej no, kev siv ciprofloxacin yuav tsum tau txiav tawm tam sim ntawd.

Hauv cov neeg mob uas muaj keeb kwm mob qaug dab peg, keeb kwm ntawm qaug dab peg, kab mob vias, thiab cov organic ua rau lub cev puas vim muaj kev pheej hmoo phiv los ntawm lub hauv nruab nrab cov hlab hlwb, ciprofloxacin yuav tsum tsuas yog rau "kev qhia tseem ceeb", nyob rau hauv cov xwm txheej uas xav tias yuav muaj kev saib xyuas ntau tshaj qhov kev pheej hmoo ntawm kev mob tshwm sim cov tshuaj.

Yog tias mob raws plab lossis ntev ntev tshwm sim thaum kho lossis tom qab kho nrog ciprofloxacin, kev kuaj mob pseudomembranous mob plab yuav tsum raug cais tawm, uas yuav tsum tau tshem tawm cov tshuaj tam sim ntawd thiab teem sijhawm kho kom tsim nyog.

Kev siv cov tshuaj uas txhawm rau txhawm plab hnyuv plab yog contraindicated. Cov neeg mob, tshwj xeeb tshaj yog cov uas muaj kab mob siab, tej zaum muaj mob cholestatic daj ntseg, nrog rau kev nce ntxiv ib ntus hauv cov kev ua ntawm "mob siab" transaminases thiab alkaline phosphatase.

Kev ua raws li cov tshuaj tsim nyog noj yog tsim nyog thaum sau tshuaj rau cov neeg mob raum thiab mob siab tsis txaus.

Qee zaum, tom qab noj thawj koob ntawm ciprofloxacin, kev tawm tsam tsis haum yuav tshwm sim, tsis tshua muaj kev poob siab anaphylactic. Ciprofloxacin nyob rau hauv cov rooj plaub no yuav tsum nres tam sim ntawd thiab kev kho tsim nyog yuav tsum tau ua.

Hauv cov neeg mob neeg laus uas tau kho nrog glucocorticosteroids, tej zaum yuav muaj kev sib tawg ntawm Achilles leeg.

Yog tias muaj mob ntawm nqaij pob txha los yog thaum thawj cov tsos mob ntawm leeg mob tshwm sim, kev kho mob yuav tsum tau txiav tawm vim qhov tseeb hais tias raug mob sib kis thiab tseem tawg ntawm cov leeg thaum kho nrog fluoroquinolones tau piav qhia.

Thaum kho ciprofloxacin, kev tiv tauj nrog kev ncaj qha tshav ntuj yuav tsum raug zam, vim tias kev hloov maj mam tso tawm kom muaj ciprofloxacin. Txoj kev kho yuav tsum tau tsum tsis ua ntxiv yog tias pom tshwm sim ntawm qhov pom kev ua kom yoog (piv txwv, kev hloov pauv ntawm daim tawv nqaij uas zoo li lub hnub ci).

Ciprofloxacin paub tias yog ib tus neeg nruab nrab inhibitor ntawm CYP1A2 isoenzyme.

Ceev faj yuav tsum tau tawm dag zog thaum siv ciprofloxacin thiab tshuaj metabolized los ntawm isoenzyme no, xws li theophylline, methylxanthine, caffeine, vim tias kev nce rau hauv cov concentration ntawm cov tshuaj no hauv cov ntshav cov ntshav tuaj yeem ua rau tshwm sim kev mob tshwm sim.

Txhawm rau kom tsis txhob muaj kev txhim kho crystalluria, nws tsis tuaj yeem lees paub ntau dua qhov xav tau txhua hnub, cov dej haus kom txaus (raug rau lub cev diuresis) thiab kev saib xyuas cov tshuaj tiv thaiv acidic zis kuj tsim nyog.

Hauv qhov muaj mob ntawm chaw mos, txawm tias yog los ntawm Neisseria gonorrhoeae hom muaj peev xwm tiv thaiv kab mob fluoroquinolones, cov ntaub ntawv hauv zos ntawm ciprofloxacin tsis kam yuav tsum tau txiav txim siab thiab muaj kev tiv thaiv kab mob yuav tsum tau lees paub hauv chav kuaj teCmax.

Cuam tshuam rau lub peev xwm los tsav tsheb, cov tshuab:

Cov neeg mob noj ciprofloxacin yuav tsum ua tib zoo saib xyuas thaum tsav tsheb thiab ua haujlwm rau lwm yam kev phom sij uas yuav tsum muaj kev saib xyuas ntau dua thiab nrawm rau cov kev puas siab puas ntsws.

Tsuas tshuaj thiab tswj hwm

Cifran nyob rau hauv daim ntawv ntawm kev daws rau Txoj kev lis ntshav yog kho nyob rau hauv rooj plaub uas tus neeg mob tsis tuaj yeem noj tshuaj. Tom qab txhim kho tus neeg mob tus mob, nws yuav tsum pauv mus rau daim ntawv ntsiav tshuaj ntawm cov tshuaj.

Cov ntsiav tshuaj tau noj ntawm qhov ncauj tag nrho, ntxhua nrog cov kua txaus. Nws yog qhov ua tau los siv cov tshuaj tsis hais txog kev noj zaub mov, tab sis thaum noj ntawm lub plab tsis muaj zog, cov tshuaj nquag yuav nqus sai dua, thiab koj yuav tsum tsis txhob haus cov tshuaj nrog cov khoom noj muaj mis lossis haus uas muaj cov calcium. Cov calcium uas nyob hauv cov zaub mov tsis cuam tshuam rau kev nqus ntawm cov tshuaj.

Cov lus pom zoo rau cov tshuaj ntau npaum li cas ntawm cov tshuaj:

cov kab mob ua pa tsawg dua: 500 mg 2 zaug hauv ib hnub (rau mob sib khuav mus rau mob me), 750 mg 2 zaug ib hnub (rau mob hnyav), rau 7-14 hnub,
Cov mob ENT: 500 mg 2 zaug ib hnub, rau 10 hnub,
kis kab mob ntawm cov pob txha thiab pob qij txha: 500 mg 2 zaug hauv ib hnub (rau mob hnyav mus rau mob hnyav), 750 mg 2 zaug ib hnub (rau mob hnyav), rau 4-6 lub lis piam,
kev kis mob ntawm daim tawv nqaij thiab cov nqaij mos mos: 500 mg 2 zaug hauv ib hnub (rau mob hnyav mus rau mob hnyav), 750 mg 2 zaug hauv ib hnub (rau mob hnyav) rau 7-14 hnub,
campylobacteriosis, shigellosis, neeg ncig ua si raws plab: 500 mg 2 zaug ib hnub rau 5-7 hnub,
typhoid fever: 500 mg 2 zaug hauv ib hnub, rau 10 hnub,
muaj mob hnyav hauv plab: 500 mg 2 zaug hauv ib hnub rau 7-14 hnub,
kev kis mob ntawm lub raum thiab mob tso zis: 250 mg 2 zaug ib hnub (rau kis tsis yooj yim), 500 mg 2 zaug ib hnub (rau kev nyuaj) rau 7-14 hnub, tsis pom tus mob cystitis rau cov poj niam - 250 mg 2 zaug hauv ib hnub rau 3 hnub ,
mob kis kab mob (tsis yooj yim): 250-500 mg noj ib zaug,
cov kab mob ua rau mob prostatitis: 500 mg 2 zaug ib hnub twg rau 28 hnub,
sepsis, mob peritonitis: 750 mg 2 zaug ib hnub,
Mob ntsws pulmonary anthrax (kev tiv thaiv thiab kev kho mob): 500 mg 2 zaug hauv ib hnub rau 60 hnub.

Txog rau lwm cov mob, cov koob tshuaj pom zoo yog 500 mg 2 zaug ib hnub.

Cov neeg laus yuav tsum siv cov tshuaj kom tsawg (qhov ntau npaum li cas los ntawm qhov kis mob hnyav thiab kev paub ntawm tus kheej).

Kev siv Cyfran hauv kev kho mob ntshav:

cov teeb meem tshwm sim los ntawm Pseudomonas aeruginosa, tawm tsam keeb kwm ntawm pulmonary cystic fibrosis hauv cov menyuam hnub nyoog 5-17 xyoo: 20 mg / kg 2 zaug hauv ib hnub, ntau kawg koob - 1500 mg, rau 10-14 hnub,
Mob ntsws pulmonary anthrax (prophylaxis thiab kev kho mob): 15 mg / kg 2 zaug hauv ib hnub, qhov koob tshuaj ntau tshaj plaws yog 500 mg, koob tshuaj txhua hnub yog 1000 mg, rau 60 hnub (kho yuav tsum tau pib sai li sai tau tom qab xav paub lossis paub tseeb hais tias muaj tus kab mob).

Cov neeg mob es lub raum khiav tsis zoo:

nrog creatinine tshem tawm (CC) ntawm 31-60 ml / min, qhov siab tshaj plaws niaj hnub noj tshuaj yog 1000 mg (250-500 mg txhua 12 teev),
nrog CC tsawg dua 30 ml / min, qhov ntau tshaj ib hnub ntawm cov tshuaj yog 500 mg (250-500 zaug hauv 18 teev).

Cov neeg mob ntawm hemodialysis yuav tsum siv cov tshuaj tom qab cov txheej txheem no.

Yog tias ua rau lub siab ua haujlwm tsis zoo, yuav tsum tau txhaj tshuaj Cyfran kho kom haum.

Cov tshuaj yuav tsum txuas ntxiv tsawg kawg 3 hnub tom qab ploj ntawm cov tsos mob ntawm tus kab mob.

Cov lus pom zoo rau lub sijhawm kho nrog Cifran:

kab mob gonorrhea (uncomplicated): 1 hnub,
txhaj tshuaj: thoob plaws tag nrho lub sijhawm ntawm neutropenia,
osteomyelitis: qhov siab kawg ntawm cov tshuaj yog 60 hnub,
lwm yam mob: 1-2 lub lis piam,
kab mob streptococcal: lub sijhawm tsawg kawg ntawm kev kho mob yog 10 hnub.

Txoj kev lis ntshav daws

Txhawm rau tiv thaiv qhov tsis xav ua nyob rau ntawm thaj chaw infusion, Cifran pom zoo kom txhaj rau txoj hlab ntshav loj kom ntev li 60 feeb.

Cov koob tshuaj tau txiav txim siab nyob ntawm qhov mob hnyav, nws hom, qhov xwm txheej dav dav ntawm tus neeg mob, nws lub hnub nyoog thiab lub cev qhov hnyav, nrog rau lub raum ua haujlwm.

Cov tshuaj pom zoo:

cov kab mob ua pa: 400 mg 2-3 zaug ib hnub, nyob ntawm tus mob hnyav,
kev sib kis ntawm cov kab mob genitourinary: 200-400 mg 2 zaug hauv ib hnub (mob hnyav, tsis yooj yim, piv txwv li, kab mob gonorrhea), 400 mg 2-3 zaug hauv ib hnub (nyuaj, xws li prostatitis, adnexitis), 400 mg 3 zaug hauv ib hnub (muaj kev phom sij thiab tshwj xeeb muaj mob hnyav, xws li mob sepsis, mob peritonitis, mob pob txha thiab pob qij txha),
anthrax pulmonary anthrax: 400 mg 2 zaug hauv ib hnub (rau cov neeg laus), 10 mg / kg 2 zaug hauv ib hnub (rau menyuam yaus), ib koob ntau tshaj - 400 mg, ib hnub - 800 mg, rau 60 hnub (pib kho sai li sai tau tom qab xav tias yog tus mob los yog paub tseeb hais tias muaj tus kab mob),
lwm yam kev kis mob: 400 mg 2 zaug hauv ib hnub, yog tias muaj mob hnyav - 3 zaug hauv ib hnub, rau 1-2 lub lis piam, yog tias tsim nyog, kev nce sij hawm ntxiv hauv lub sijhawm kho mob thiaj li ua tau.

Cov neeg mob es lub raum khiav tsis zoo:

nrog CC 30-60 ml / min, qhov ntau tshaj ib hnub ntawm cov tshuaj yog 800 mg,
nrog CC tsawg dua 30 ml / min, qhov ntau tshaj ib hnub ntawm cov tshuaj yog 400 mg.

Cov tshuaj yuav tsum txuas ntxiv tsawg kawg 3 hnub tom qab ploj ntawm cov tsos mob ntawm tus kab mob.

Cov lus pom zoo rau lub sijhawm kho nrog Cifran:

kab mob gonorrhea (uncomplicated): 1 hnub,
txhaj tshuaj: thoob plaws tag nrho lub sijhawm ntawm neutropenia,
osteomyelitis: qhov siab kawg ntawm cov tshuaj yog 60 hnub,
lwm yam mob: 1-2 lub lis piam,
kab mob streptococcal, mob sib kis mob los ntawm chlamydia: cov sijhawm tsawg kawg ntawm kev kho mob yog 10 hnub.