Metformin: cov lus qhia rau kev siv, analogues thiab tshuaj xyuas, tus nqi hauv cov khw muag tshuaj hauv Lavxias

Metformin yog ib qhov ncauj tshuaj hypoglycemic rau kev kho mob ntshav qab zib hom 2.

Cov tshuaj inhibits gluconeogenesis nyob rau hauv daim siab, txo qhov nqus ntawm cov piam thaj los ntawm cov hnyuv, ua kom zoo rau kev siv lub cev ntawm cov piam thaj, thiab tseem ua rau kev nkag siab ntawm cov ntaub so ntswg mus rau insulin.

Nws tsis cuam tshuam qhov zais cia ntawm insulin los ntawm beta hlwb ntawm tus txiav, tsis ua rau kev tsis tuaj yeem tshwm sim.

Nws txo cov ntshav ntawm cov thyroid stimulating hormone hauv cov ntshav, cov qib roj cholesterol thiab lipoproteins tsawg ntom, thiab tseem tiv thaiv kab mob kev hloov pauv hauv cov hlab ntshav.

Kev siv cov Metformin pab txhim kho cov ntshav coagulability, txhim kho nws lub zog rheological, ntxiv rau txo qis kev pheej hmoo ntawm thrombosis. Txuas ntxiv pab rau kom poob phaus hauv rog.

Kev Sib xyaw Metformin (1 ntsiav tshuaj):

Metformin - 500 mg
Cov muaj mob: povidone, pob kws nplej siab, crospovidone, magnesium stearate, talc,
Lub plhaub muaj pes tsawg leeg: methacrylic acid thiab methyl methacrylate copolymer, macrogol, titanium dioxide, talc.

Kev ntsuas rau siv

Dab tsi yog Metformin rau? Raws li cov lus qhia, cov tshuaj yog tshuaj hauv cov kis hauv qab no:

Raws li ib yam tshuaj siv rau cov neeg muaj ntshav qab zib hom 2 tsis muaj ketoacidosis nrog kev tsis muaj txiaj ntsig ntawm kev noj zaub mov noj (tshwj xeeb tshaj yog rau cov neeg mob rog).
Ua ke nrog cov tshuaj insulin, cov tshuaj no yog siv rau hom 2 mob ntshav qab zib mellitus, uas nrog cov tshuaj tiv thaiv kab mob insulin ntxiv (tshwj xeeb yog cov neeg mob rog rog hnyav).

Cov lus qhia rau kev siv Metformin, ntau npaum

Cov tshuaj yuav tsum tau noj qhov ncauj tsis tas yuav zom ib ntsiav tshuaj thaum noj mov lossis tom qab noj mov tas. Qhov ntau npaum li cas yog muab rau txhua tus neeg mob, raws li kev soj ntsuam cov ntshav ntawm cov ntshav qabzib.

Thawj koob tshuaj rau cov neeg laus pom zoo los ntawm Metformin yog 500 mg los ntawm 1 mus rau 3 zaug hauv ib hnub lossis 850 mg ntawm 1 txog 2 zaug ib hnub. Yog tias tsim nyog, thaum ncua sijhawm ntawm 1 lub lis piam, ntau npaum li cas yog maj mam nce, nce txog 2000-3000 mg.

Qhov nyiaj siab pub rau txhua hnub rau cov neeg mob laus yog 1000 mg.

Thawj koob tshuaj rau cov menyuam muaj hnub nyoog tshaj 10 xyoo yog 500 lossis 850 mg 1 zaug hauv ib hnub lossis 500 mg 2 zaug hauv ib hnub. Yog tias tsim nyog, cov tshuaj txhua hnub yog maj mam nce, nce txog 2000 mg hauv 2-3 koob.

Thaum ua qhov kev kho ua ke, cov koob tshuaj ntawm Metformin raws li cov lus qhia yog los ntawm 500 rau 850 mg 2-3 zaug ib hnub. Kev noj cov kua dej ntawm cov tshuaj insulin yog xaiv ib tus zuj zus nyob ntawm seb cov piam thaj hauv cov ntshav nyob rau hauv cov ntshav.

Qhov siab tshaj plaws ntawm cov tshuaj hauv cov ntshav ntshav yog pom 2.5 teev tom qab kev coj noj coj ua, tom qab 6 teev nws pib poob. Tom qab 1-2 hnub ntawm kev nquag ua ntu zus, ib lub siab xav ntawm cov tshuaj hauv cov ntshav tau tsim muaj.

Qhov koob tshuaj hloov kho tau pom zoo 7-15 hnub tom qab pib siv tshuaj.

Vim tias qhov pheej hmoo ntawm cov kab mob lactic acidosis, cov koob tshuaj yuav tsum tau txo qis hauv cov teeb meem hauv lub cev zom zaub mov tsis haum xeeb.

Sab sij huam

Cov kev qhia ceeb toom ceeb toom txog qhov ua tau ntawm kev txhim kho cov kev mob tshwm sim hauv qab no thaum muab tshuaj Metformin:

Lub plab zom mov - "nws yog xim hlau" saj hauv lub qhov ncauj, xeev siab, ntuav raws sij hawm, mob plab, zawv plab, tsis qab los noj mov kom txog thaum nws qhaj tag (tsis nco qab), flatulence (nce roj tsim hauv plab hnyuv).
The endocrine system yog hypoglycemia (kev txo qis hauv cov ntshav qab zib cov ntsiab lus qis dua ib txwm).
Metabolism - lactic acidosis (nce siab ntawm cov lactic acid hauv cov ntshav), tsis tuaj yeem cuam tshuam ntawm cov vitamin B12 los ntawm txoj hnyuv.
Cov ntshav thiab cov pob txha pob txha liab - megaloblastic anemia (anemia cuam tshuam nrog kev ua txhaum ntawm kev tsim thiab kev loj hlob ntawm cov qe ntshav liab hauv cov pob txha pob txha vim tsis muaj cov vitamin B12 txaus) tsis tshua muaj tshwm sim.
Ua xua - tawv nqaij ua pob khaus thiab khaus.

Cov kev mob tshwm sim los ntawm kev mob plab hnyuv feem ntau tshwm sim thaum pib kho nrog tshuaj thiab ploj mus ntawm lawv tus kheej. Txhawm rau txo qis qhov mob hnyav sai li sai tau, antacids, tshuaj antispasmodics thiab atropine-zoo li tshuaj yog kws kho mob sau los ntawm kws kho mob.

Cov Yuav Tsum Muaj

Metformin yog sib kis hauv cov xwm txheej hauv qab no:

Lub siab lossis raum tsis ua haujlwm,
Lactic acidosis (suav nrog keeb kwm)
Ntshav qab zib ketoacidosis
Cov neeg quav cawv quav cawv lossis qaug cawv,
Mob ntshav qab zib precoma, coma
Cov lus sib tw hais txog kev mob ntsws ntev thiab mob tuaj yeem ua rau kev loj hlob ntawm cov nqaij mos hypoxia (piv txwv li, ua pa lossis mob hlab plawv tsis ua haujlwm, mob myocardial infarction),
Ua raws li kev noj haus hypocaloric (thaum noj tsawg dua 1000 calories tauj ib hnub),
Cov mob hnyav nrog kev pheej hmoo ntawm kev txhim kho lub raum ua haujlwm, piv txwv li, lub cev qhuav dej nrog ntuav lossis zawv plab, kis mob hnyav, kub taub hau, mob hypoxia (nrog rau cov mob ntsws, mob raum, sepsis, poob siab),
Daim ntawv thov 2 hnub ua ntej thiab tsis pub dhau 2 hnub tom qab kev tshawb radiological los yog radioisotope nrog kev qhia ntawm tus neeg sawv cev sib piv uas muaj iodine,
Kev raug mob hnyav thiab phais mob (hauv qhov uas yuav tsum tau kho tshuaj insulin),
Cev xeeb tub thiab lactation
Lub xub ntiag ntawm kev ua kom tsis haum xeeb rau metformin hydrochloride lossis lwm yam tshuaj tiv thaiv.

Sau ntawv ceeb toom rau cov neeg muaj hnub nyoog 60 xyoo rov hauv uas ua haujlwm hnyav lub cev (kev pheej hmoo ntawm kev mob lactic acidosis).

Noj ntau dhau

Thaum tus neeg noj ntau dhau, tus kab mob lactic acidosis tuaj yeem pib tshwm sim, tsos mob - ntuav, xeev siab, mob leeg nqaij, zawv plab, mob plab. Yog tias tsis tau txais kev pab kom raws sijhawm, kiv taub hau, hnov qab thiab tsis nco qab yuav pib mob.

Qhov kev ua tau zoo tshaj plaws ntawm kev tshem tawm metformin hauv lub cev yog hemodialysis. Tom ntej no, kev kho cov tsos mob yog kws kho.

Analogs Metformin, tus nqi hauv cov khw muag tshuaj

Yog tias tsim nyog, koj tuaj yeem hloov Metformin nrog cov tshuaj tiv thaiv rau cov tshuaj nquag - cov no yog cov tshuaj:

Thaum xaiv cov analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv Metformin, tus nqi thiab tshuaj xyuas tsis siv rau cov tshuaj uas muaj cov nyhuv zoo sib xws. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Tus nqi hauv cov khw muag tshuaj Lavxias: Metformin 500 mg 60 ntsiav tshuaj - los ntawm 90 txog 120 rubles, Metformin Zentiva 850 mg 30 ntsiav tshuaj - los ntawm 93 txog 149 rubles, tus nqi ntawm Metformin canon 500 mg 60 ntsiav tshuaj - los ntawm 130 txog 200 rubles, raws li 726 chaw muag tshuaj.

Khaws rau hauv qhov chaw qhuav kom tsis txhob nkag tau rau cov menyuam yaus ntawm qhov kub ntawm + 15 ... + 25 ° C. Txee lub neej yog 3 xyoos.

Pharmacological kev txiav txim

Metformin yog cov khoom hauv chav kawm. lojmuas, nws cov tshuab ntawm kev ua yog pom vim muaj kev cuam tshuam ntawm cov txheej txheem gluconeogenesis hauv lub siab, nws txo qhov kev nqus ntawm cov piam thaj los ntawm txoj hnyuv, txhim kho cov txheej txheem ntawm kev siv peripheral qabzib, nce qib ntawm cov nqaij ua rau kev txiav txim siab tshuaj insulinCov. Tsis cuam tshuam rau cov txheej txheem ntawm cov tshuaj insulin los ntawm beta hlwb ntawm tus txiav, tsis ua kev puas tsuaj rau kev tsis haum tshuaj. Raws li qhov tshwm sim, nws nres hyperinsulinemia, uas yog qhov tseem ceeb ua rau qhov hnyav nce thiab nce qib ntawm cov teeb meem vascular muaj mob ntshav qab zibCov. Raws li nws lub hwj huam, lub cev nyhav los yog qis dua lossis poob qis.

Lub cuab tam txo cov ntsiab lus hauv ntshavtriglyceridesthiab linoproteinstsawg ntom ntom. Txo tus nqi ntawm cov rog ua kom tsis muaj zog, inhibits kev tsim cov roj dawb. Nws cov nyhuv fibrinolytic yog sau tseg, inhibiting PAI-1 thiab t-PA.

Cov tshuaj tshem tawm txoj kev loj hlob ntawm kev loj hlob ntawm cov nqaij pob qij txha ntawm lub cev vascular. Muaj txiaj ntsig zoo ntawm lub xeev ntawm cov hlab plawv system, tiv thaiv kev txhim kho mob ntshav qab zib angiopathy.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov ntsiav tshuaj Enteric coated, Metformin muaj qhov hloov puag ncig, biconvex nto thiab xim dawb. Lub ntsiab tseem ceeb ntawm cov tshuaj yog metformin hydrochloride, nws cov ntsiab lus hauv ib ntsiav tshuaj yog 500 mg. Tsis tas li, nws muaj pes tsawg leeg suav nrog cov khoom siv sib txuam, uas suav nrog:

Crospovidone.
Talc.
Magnesium stearate.
Pob kws nplej siab.
Methacrylic acid thiab methyl methacrylate copolymer.
Povidone K90.
Titanium dioxide
Macrogol 6000.

Cov tshuaj Metformin tau ntim rau hauv ib lub paug blooj ntawm 10 daim. Daim npav pob ntawv muaj 3 lub hlwv (30 ntsiav tshuaj) thiab ib qho lus piav qhia txog kev siv tshuaj.

Dab tsi yog Metformin rau?

Kev noj cov tshuaj Metformin yog qhia txog kev txo qis cov ntshav qabzib hauv cov ntshav uas tsis muaj cov tshuaj insulin-yam muaj ntshav qab zib 2 mellitus thaum tsis kho tshuaj los ntawm kev txhim kho kev noj haus. Cov tshuaj kuj tseem siv ua ke nrog cov tshuaj insulin rau cov mob ntshav qab zib hom 2 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog rau cov tib neeg muaj lub cev hnyav dua.

Cov Yuav Tsum Muaj

Noj Metformin ntsiav tshuaj yog contraindicated nyob rau hauv lub xub ntiag ntawm ib tug xov tooj ntawm pathological thiab physiological tej yam kev mob ntawm lub cev, uas muaj xws li:

Hypersensitivity rau cov tshuaj nquag lossis ntu Cheebtsam ntawm cov tshuaj.
Tus kab mob ntshav qab zib ketoacidosis (cim tau nce hauv cov ntshav qabzib nrog kev hloov pauv hauv cov metabolism thiab kev sib txuam ntawm ketone lub cev hauv lub cev), cov mob ntshav qab zib ua rau mob plab thiab tsis nco qab (tsis nco qab tiv thaiv keeb kwm ntawm cov piam thaj ntau).
Kev ua tsis zoo rau lub raum.
Mob voos xwm txheej, uas yog nrog txoj kev pheej hmoo siab raum tsis ua haujlwm - lub cev qhuav dej (lub cev qhuav dej) ntawm lub cev nrog mob raws plab, ntuav, mob sib kis nrog cov mob hnyav thiab ua npaws.
Cov xwm txheej ntawm hypoxia hauv sepsis (mob ntshav), mob myocardial infarction (kev tuag ntawm qee qhov ntawm lub plawv), lub siab lossis ua pa tsis ua haujlwm.
Nqa cov volumetric kev phais mob, raug mob hnyav, xav tau kev qhia ntawm cov insulin rau kev kho sai sai (kho) ntawm cov nqaij hauv thaj chaw ntawm kev puas tsuaj.
Kev ua txhaum ntawm kev ua haujlwm ntawm lub siab.
Daim ntawv thov nyob rau hauv 2 hnub ua ntej lossis tom qab radioisotope thiab kev tshawb fawb radiographic ntawm lub cev muaj feem nrog kev qhia ntawm radioactive isotope ntawm iodine.
Lactic acidosis (kev nce ntxiv ntawm theem ntawm cov kab mob lactic acid hauv cov ntshav, tom qab los ntawm kev hloov pauv rau cov tshuaj tiv thaiv rau sab acidic), nrog rau yav dhau los.
Kev ua raws li kev noj zaub mov kom tsawg-tsawg (hauv qab 1000 kcal tauj ib hnub).
Cev xeeb tub nyob rau txhua ntu ntawm chav kawm thiab pub niam mis.

Nrog kev ceev faj, Metformin ntsiav tshuaj siv rau hauv cov neeg laus dua 60 xyoo lossis tawm tsam keeb kwm ntawm lub zog ua haujlwm lub cev (qhov kev pheej hmoo siab yuav ua rau cov tshuaj lactic acid hauv cov ntshav ntau ntxiv). Ua ntej noj cov tshuaj, koj yuav tsum paub tseeb tias tsis muaj kev tiv thaiv kev tsis sib haum.

Tsuas tshuaj thiab tswj hwm

Metformin ntsiav tshuaj noj ntawm qhov ncauj nrog zaub mov lossis tam sim ntawd tom qab noj. Tsis txhob zom cov ntsiav tshuaj thiab haus dej ntau. Txhawm rau txo qhov zoo li ntawm kev txhim kho cov nyom tshwm sim los ntawm lub plab zom mov, cov tshuaj txhua hnub yog noj, faib rau 2-3 koob. Tus kws kho mob teev qhov ntau thiab tsawg ntawm cov tshuaj ib leeg zuj zus, nyob ntawm seb thawj zaug cov suab thaj hauv cov ntshav tau zoo li cas, thiab kev kho kom zoo li cas. Feem ntau, cov tshuaj pib yog 500-1000 mg ib hnub (1-2 ntsiav tshuaj). Tom qab 10-15 hnub, nyob ntawm theem ntawm cov piam thaj hauv cov ntshav, nws muaj peev xwm nce cov tshuaj ntau ntxiv ntawm Metformin ntsiav tshuaj rau 1500-2000 mg ib hnub. Qhov siab kawg txhua hnub noj tshuaj yuav tsum tsis pub tshaj 3000 mg. Hauv cov neeg laus, qhov siab tshaj plaws qhov kev kho txhua hnub yuav tsum tsis pub tshaj 1000 mg.

Cov lus qhia tshwj xeeb

Ua ntej noj cov tshuaj Metformin, koj yuav tsum ua tib zoo nyeem cov lus qhia rau cov tshuaj. Muaj ntau ntau cov lus qhia tshwj xeeb txog nws qhov kev siv, uas suav nrog:

Nrog cov tsos ntawm cov leeg mob (myalgia) tom qab pib siv yeeb tshuaj, ib qho kev txiav txim siab hauv chaw kuaj ntshav ntawm qib lactic acid hauv cov ntshav tau nqa tawm.
Kev siv sijhawm ntev siv cov tshuaj yuav tsum muaj kev tshuaj xyuas txhua lub sijhawm ntawm kev sim ntsuas ntawm lub cev ua haujlwm ntawm lub raum.
Nrog rau kev siv ua ke ntawm Metformin ntsiav tshuaj nrog cov tshuaj tau los ntawm sulfonylureas, ceev faj txhua lub sijhawm saib xyuas cov ntshav qabzib yuav tsum muaj.
Lub sijhawm kho mob yuav tsum tsis txhob haus cawv thiab tshuaj muaj tshuaj ethanol.
Cov tshuaj Metformin tuaj yeem cuam tshuam nrog cov tshuaj ntawm lwm pawg pharmacological, yog li ntawd, thaum noj lawv, nws yog qhov yuav tsum ceeb toom cov kws kho mob uas tuaj kawm txog qhov no.
Yog tias cov tsos mob ntawm tus mob bronchopulmonary thiab genitourinary pathology tshwm sim keeb kwm ntawm kev noj tshuaj, nws txoj kev siv yuav tsum nres thiab sab laj nrog kws kho mob.
Cov tshuaj tsis cuam tshuam ncaj qha rau cov kev ua haujlwm ntawm lub hlwb, cortex, txawm li cas los xij, thaum siv nrog lwm cov kab mob hypoglycemic, qhov kev pheej hmoo ntawm hypoglycemia nce, yog li ntawd, thaum ua haujlwm ua haujlwm koom nrog kev xav tau nce ntxiv ntawm kev saib xyuas thiab ceev ntawm psychomotor cov tshuaj tiv thaiv, yuav tsum ceev faj.

Hauv cov khw muag tshuaj network, Metformin ntsiav tshuaj muaj nyob rau hauv cov tshuaj. Kev tswj hwm tus kheej yam tsis tau tshuaj yam tsis tsim nyog yuav tsis pom zoo.

Noj ntau dhau

Nrog rau qhov muaj nuj nqi ntau dhau ntawm cov tshuaj kho pom zoo ntawm cov tshuaj Metformin, cov tshuaj lactic acid hauv cov ntshav nce siab (lactic acidosis). Qhov no nrog rau xeev siab, ntuav, raws plab, txo qhov kub ntawm lub cev, mob hauv cov leeg thiab plab, thiab ua pa ceev. Hauv qhov no, cov tshuaj yuav tsum tsis ua mus ntxiv. Kev noj tshuaj ntau dhau yog nqa hauv tsev kho mob nrog kev pab los ntawm hemodialysis (kho vajtse lim ntshav).

Raws li cov tshuaj nquag thiab cov nyhuv tshuaj kho, cov tshuaj Metfogamma, Glucofage, Formmetin zoo sib xws rau Metformin ntsiav tshuaj.

Pharmacokinetics thiab cov chaw muag tshuaj

Tom qab Metformin noj ntawm qhov ncauj, qhov siab tshaj plaws tau pom nyob hauv ntshav tom qab 2.5 teev. Hauv cov neeg uas tau txais cov tshuaj nyob rau hauv cov koob tshuaj ntau, cov ntsiab lus siab tshaj plaws ntawm cov kev ua ub no nyob rau hauv cov ntshav tsis siab tshaj 4 μg / ml.

Kev nqus ntawm cov khoom nquag nres nres 6 teev tom qab kev tswj hwm. Raws li qhov tshwm sim, plasma concentration txo. Yog hais tias tus neeg mob noj cov koob tshuaj pom zoo, tom qab 1-2 hnub ib qho chaw ruaj khov ntawm cov tshuaj nquag tau pom nyob hauv cov ntshav ntawm qhov ciaj ciam ntawm 1 μg / ml lossis tsawg dua.

Yog tias cov tshuaj noj thaum noj mov, ces qhov nqus ntawm cov khoom xyaw txuam tsawg dua. Nws accumulates tsuas yog nyob rau hauv cov phab ntsa ntawm lub raj xa dej.

Nws ib nrab-lub neej yog kwv yees li 6.5 teev. Qib qeb kev noj qab haus huv nyob hauv cov neeg noj qab haus huv yog 50-60%. Nrog cov plasma protein, nws txoj kev sib raug zoo yog qhov tsis tuaj yeem. Kwv yees li 20-30% ntawm koob tshuaj tawm los ntawm lub raum.

Sab sij huam

Feem ntau cov feem ntau, thaum noj cov tshuaj, phiv phiv hauv cov haujlwm yog manifested lub plab zom mov: xeev siab zawv plabntuav, mob plab, ntxhias qab losCov tsos ntawm metallic saj hauv lub qhov ncauj. Raws li txoj cai, cov kev coj ua tshwm sim thaum thawj zaug pib noj cov tshuaj. Feem ntau, lawv ploj ntawm lawv tus kheej nrog rau kev siv tshuaj ntxiv.

Yog tias tus neeg muaj lub siab rhiab rau cov tshuaj, txoj kev txhim kho erythema yog ua tau, tab sis qhov no tsuas tshwm sim hauv qee yam tsis tshua muaj. Nrog rau kev txhim kho ntawm kev mob tshwm sim uas tsis tshua muaj pes tsawg - mob erythema - nws yog qhov tsim nyog kom thim txoj kev txais tos.

Nrog rau kev kho mob ntev, qee tus neeg mob ua rau muaj kev cuam tshuam ntawm kev nqus tus txheej txheem. Vitamin B12Cov. Raws li qhov tshwm sim, nws qib hauv ntshav dej tsawg ntshavuas tuaj yeem ua txhaum hematopoiesis thiab kev loj hlob megaloblastic anemia.

Metformin ntsiav tshuaj, cov lus qhia rau kev siv (tus qauv thiab ntau npaum)

Nws yog ib qho tsim nyog kom nqos cov ntsiav tshuaj tag nrho thiab haus lawv nrog dej kom ntau. Lawv haus cov tshuaj tom qab noj mov. Yog tias nws nyuaj rau ib tug neeg nqos 850 mg ntsiav tshuaj, nws tuaj yeem faib ua ob ntu, uas tau noj tam sim ntawd, ib qho zuj zus. Thaum pib, noj tshuaj ntawm 1000 mg ib hnub twg noj, qhov tshuaj no yuav tsum tau muab faib ua ob lossis peb koob tshuaj txhawm rau kom tsis txhob muaj kev phiv. Tom qab 10-15 hnub, qhov koob tshuaj tau nce zuj zus. Kev tso cai ntau tshaj plaws ntawm kev noj tshuaj 3000 mg ib hnub.

Yog tias cov laus noj Metformin, lawv yuav tsum tau saib xyuas lawv lub raum tas li. Kev kho txhua yam kev ua si tuaj yeem tau tom qab ob lub lis piam tom qab pib kho mob.

Yog tias tsim nyog, pib noj tshuaj Metformin tom qab noj lwm qhov tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj, koj yuav tsum xub tso tseg kev kho mob nrog cov yeeb tshuaj zoo li no, thiab tom qab ntawd pib noj cov tshuaj Metformin hauv cov tshuaj tshwj xeeb.

Yog tias tus neeg mob muab cov tshuaj insulin thiab Metformin, tom qab thawj ob peb hnub koj yuav tsum tsis txhob hloov pauv ntawm cov tshuaj insulin li ib txwm. Ntxiv mus, cov koob tshuaj insulin tuaj yeem txo qis qis dua los ntawm kev saib xyuas ntawm kws kho mob.

Cov lus qhia rau siv Metformin Richter

Tus kws kho mob teeb tsa cov tshuaj ntau npaum li cas, nws nyob ntawm tus neeg mob ntshav qab zib. Thaum noj 0.5 g ntsiav tshuaj, thawj qhov kev siv tshuaj yog 0.5-1 g ib hnub. Ntxiv mus, cov koob tshuaj tuaj yeem nce ntxiv yog tias tsim nyog. Qhov kev txhaj tshuaj ntau tshaj plaws hauv ib hnub yog 3 g.

Thaum noj 0.85 g ntsiav tshuaj, thawj qhov kev siv yog 0.85 g ib hnub. Ntxiv mus, yog tias tsim nyog, nws yog nce. Qhov kev txhaj tshuaj ntau tshaj yog 2.55 g ib hnub.

Kev sib txuam

Metformin thiab sulfonylurea derivatives yuav tsum ua tib zoo ua ke vim muaj kev pheej hmoo ntawm hypoglycemia.

Qhov ua rau lub ntsej muag ntshav txo qis thaum noj cov kab mob mentsis thiab lub cev glucocorticosteroids, glucagon, sympathomimetics, gestagens, adrenaline, cov tshuaj hormones lub qog ua haujlwm tshuaj estrogenderivatives ntawm nicotinic acid, thiazide diuretics, phenothiazines.

Thaum noj Cimetidine Kev tshem tawm ntawm cov tshuaj metformin los ntawm lub cev qeeb, vim li ntawd, qhov kev pheej hmoo ntawm tshwm sim ntawm lactic acidosis nce.

Cov nyhuv rau hypoglycemic yog potentiated los ntawm β2-adrenoreceptor antagonists, angiotensin-hloov tus yam ntxwv tshuaj tiv thaiv, clofibrate derivatives, monoamine oxidase inhibitors, non-steroidal anti-inflammatory tshuaj thiab oxytetracycline, cyclophosphamidederivatives ntawm cyclophosphamide.

Thaum siv cov tshuaj sib txuas ntawm cov ntshav lossis cov tshuaj sib txuas nrog cov ntsiab lus iodine, uas yog siv rau kev tshawb nrhiav X-ray, ua ke nrog Metformin, tus neeg mob tuaj yeem tsim kho lub raum tsis ua hauj lwm, thiab tseem yuav ua rau muaj kev muaj feem lactic acidosis. Nws yog ib qho tseem ceeb uas yuav ncua kev txais tos ua ntej cov txheej txheem no, lub sijhawm nws thiab ob hnub tom qab. Ntxiv mus, cov tshuaj muaj peev xwm rov qab tau thaum kev ua haujlwm lub raum rov qab ntsuas tau zoo li qub.

Thaum noj cov tshuaj tiv thaiv kab mob chlorpropamazine nyob rau hauv cov koob tshuaj siab, cov ntshav qabzib nce thiab insulin tso yog inhibited. Yog li ntawd, qhov nce ntxiv ntawm cov koob tshuaj insulin yuav tsim nyog. Tab sis ua ntej ntawd, nws yog ib qho tseem ceeb uas tswj koj cov ntshav qab zib.

Yuav kom zam hyperglycemiayuav tsum tsis txhob xyaw nrog Danazol.

Nrog concomitant siv sijhawm ntev nrog metformin Vancomycin, Amilorida, Quinine, Morphine, Quinidine, Ranitidine, Cimetidine, Procainamide, Nifedipine, Triamterena plasma concentration ntawm metformin nce 60%.

Metformin kev nqus poob qis qeeb Qhuas thiab Cholestyraminevim li no, thaum noj cov tshuaj no, cov txiaj ntsig ntawm metformin txo qis.

Txhim kho cov nyhuv ntawm sab hauv cov tshuaj tiv thaiv, uas zwm rau cov chav kawm ntawm cov npoo av.

Cov qauv ntawm Metformin

Metformin analogues yog tshuaj siv Metformin Hydrochloride, Metformin Richter, Metformin teva, Bagomet, Tshuaj nyob, Metfogamma, Glyformin, Metospanin, Siofor, Glycometer, Glycon, Vero Metformin, Orabet, Glyminfor, Ntsia hauv qab, NovoforminCov. Tseem muaj tus nab npawb ntawm cov tshuaj nrog cov teebmeem zoo sib xws (Glibenclamide lwm yam), tab sis nrog lwm cov khoom xyaw dhia.

Metformin Kev Tawv Khaub

Txawm hais tias qhov tseeb ntawm Metformin Richter lub rooj sab laj thiab lwm yam kev pab cuam feem ntau tau txais kev tshuaj xyuas txog Metformin rau qhov kev poob phaus, qhov cuab yeej no tsis yog siv los ntawm cov neeg uas xav kom tshem tawm hnyav duaCov. Cov tshuaj no rau qhov poob phaus raug siv vim nws cov txiaj ntsig cuam tshuam txog kev txo qis hauv cov ntshav qab zib thiab qhov txo qis hauv lub cev qhov hnyav. Txawm li cas los xij, yuav ua li cas noj Metformin rau qhov hnyav tuaj yeem pom tsuas yog los ntawm cov khoom tsis txaus ntseeg hauv lub network, raws li cov kws tshaj lij tsis qhia txog kev xyaum ua qhov no. Txawm li cas los xij, poob phaus nrog cov tshuaj no qee zaum ua tau rau cov neeg uas siv Metformin los kho ntshav qab zib.

Kev Tshawb Xyuas Txog Metformin

Kev tshuaj xyuas txog Metformin ntsiav tshuaj los ntawm cov neeg mob ntshav qab zib qhia tias cov tshuaj muaj txiaj ntsig thiab tso cai rau koj los tswj cov qib ntshav qabzib. Cov chaw sib tham tseem muaj cov tshuaj xyuas kom zoo rau qhov tom qab kho nrog cov tshuaj no rau PCOS. Tab sis feem ntau muaj kev txheeb xyuas thiab cov tswvyim hais txog yuav siv tshuaj li cas Metformin Richter, Metformin teva thiab lwm tus tso cai rau koj los tswj lub cev hnyav.

Ntau tus neeg siv tau tshaj tawm tias cov tshuaj muaj metforminyeej pab daws qhov hnyav phaus ntxiv. Tab sis tib lub sij hawm, kev mob tshwm sim cuam tshuam nrog txoj hnyuv plab hnyuv plab feem ntau tau tshwm sim. Hauv kev sib tham txog yuav ua li cas metformin siv rau kev poob phaus, cov tswv yim ntawm kws kho mob feem ntau tsis zoo. Lawv qhia kom tiv thaiv siv rau qhov laj thawj no, nrog rau haus cawv thaum lub sij hawm kho cov txheej txheem.

Metformin tus nqi, qhov twg yuav

Nqi Metformin hauv cov khw muag tshuaj yog nyob ntawm cov tshuaj thiab nws ntim.

Nqi Metformin teva 850 mg nruab nrab 100 rubles rau pob ntawm 30 pcs.

Yuav Metformin Canon 1000 mg (60 pcs.) Yuav yog 270 rubles.

Ntau npaum li cas yog Metformin, nyob ntawm seb muaj pes tsawg ntawm cov tshuaj hauv pob: 50 pcs. Koj tuaj yeem yuav tom tus nqi ntawm 210 rubles. Nws yuav tsum raug coj mus rau hauv tus account thaum yuav tshuaj rau qhov hnyav uas nws tau muag los ntawm cov tshuaj.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Metformin yog txiav txim los ntawm tus kws kho mob ib leeg zuj zus, nyob ntawm qhov kev mloog ntawm cov piam thaj hauv cov ntshav, cov ntsiav tshuaj noj ntawm qhov ncauj, tag nrho, thaum lossis tom qab noj mov tas, nrog ib qho kua tsawg. Txo txoj kev pheej hmoo ntawm kev phiv los ntawm txoj hnyuv, qhov kev noj tshuaj txhua hnub raug pom zoo muab faib ua 2-3 koob.

Qhov kev siv thawj zaug feem ntau yog 500-1000 mg rau ib hnub, yog tias tsim nyog (raws li cov txiaj ntsig ntawm kev txiav txim siab ntawm cov piam thaj hauv cov ntshav) tom qab 10-15 hnub, nws yuav maj mam nce ntxiv. Cov koob tshuaj txij nkawm nyob rau hauv feem ntau yuav tsum yog 1500-2000 mg rau ib hnub, qhov ntau kawg ib hnub ib zaug yuav tsum tsis pub ntau tshaj 3000 mg.

Cov neeg mob ntawm cov hnub nyoog qib siab tau pom zoo kom tsis pub ntau tshaj 1000 mg rau ib hnub.

Hauv kev mob plab zom mov tsis txaus, vim tias qhov kev hem thawj ntawm lactic acidosis ntau ntxiv, cov koob tshuaj ntawm Metformin yuav tsum raug txo kom tsawg.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev tswj hwm tib lub sijhawm ntawm cov tshuaj nrog cov tshuaj tiv thaiv kev tiv thaiv lossis danazole, ntxiv rau tom qab ua tiav lawv chav kawm, nws yuav tsum tswj hwm qhov qib ntawm glycemia thiab kho cov koob tshuaj raws ntawm Metformin.

Nws yuav tsum tau yug los hauv lub siab tias thaum ua ke nrog metformin:

Sulfonylurea derivatives, insulin, acarbose, non-steroidal anti-inflammatory drugs (NSAIDs), oxytetracycline, monoamine oxidase inhibitors (MAOs), cyclophosphamide, clofibrate derivatives, angiotensin hloov enzyme inhibitors (ACEs), β-adrenergic agonists
Chlorpromazine - muaj kev txhawb nqa hauv kev txhaj tshuaj ntau (100 mg / hnub) kom nce glycemia, txo kev tso tawm ntawm cov tshuaj insulin,
Cimetidine - ncua kev tshem tawm cov tshuaj metformin, yog li ua rau muaj kev pheej hmoo ntawm cov kab mob lactic acidosis,
Cov tshuaj tiv thaiv tsis haum, glucocorticosteroids (GCS), epinephrine, glucagon, sympathomimetics, cov thyroid hormones, nicotinic acid derivatives, phenothiazine derivatives, thiazide thiab voj diuretics txo cov nyhuv hypoglycemic.

Metformin ua rau lub zog ntawm cov tshuaj tiv thaiv tsis haum (coumarin derivatives).