Yuav siv li cas rau cov tshuaj Combogliz Prolong?

Kev sib xyaw ntawm metformin thiab DPP4 inhibitors (glyptins) raug lees paub los ntawm endocrinologist yog qhov muaj tswv yim tshaj plaws rau tus mob ntshav qab zib hom 2. Cov khoom siv feem ntau tau kawm los ntawm chav kawm ntawm gliptins yog saxagliptin. Kev sib xyaw ntawm saxagliptin nrog metformin tsau hauv ib ntsiav tshuaj mus rau muag nyob rau xyoo 2013 raws li lub npe Combogliz Prolong.

Cov nquag nyob hauv nws cov muaj pes tsawg leeg muaj qhov ua kom tiav: lawv txo insulin tsis kam thiab txhim kho cov tshuaj insulin. Ntxiv mus, cov tshuaj tau pov thawj kev nyab xeeb rau lub plawv thiab cov hlab ntsha, kev xyaum tsis ua rau cov ntshav qog, tsis ua rau nce phaus. Cov kab mob ntshav qab zib kho hauv tsev pom zoo pom zoo kom noj Combogliz Prolong rau cov neeg mob uas tsis txaus insulin. Nrog glycated hemoglobin saum toj no 9%, nws tuaj yeem kho tau sai tom qab kuaj pom ntshav qab zib.

Tus txheej txheem ntawm kev ua ntawm comboglize

Combogliz Prolong yog ib hom tshuaj siv tshuaj Asmeskas, cov cai ntawm nws yog rau cov tuam txhab Bristol Myers thiab Astra Zeneka. Ntsiav tshuaj muaj 3 kev xaiv ntau npaum li cas, uas ua rau nws xaiv cov khoom noj kom yog metformin thiab saxagliptin nyob ntawm cov yam ntxwv ntawm tus kabmob:

• 1000 mg + 2.5 mg yog qhov tsim nyog rau cov neeg mob ntshav qab zib nrog kev muaj peev xwm tiv thaiv insulin, kev rog, kev ua kom lub cev qes,
• 1000 mg + 5 mg - ib qho kev xaiv thoob plaws rau cov neeg mob ntshav qab zib nrog kev txo qis cov tshuaj lom neeg thiab cov rog hnyav dhau,
• 500 + 5 mg yog siv thaum pib kho nrog Combogliz Prolong, tuaj yeem siv txuas ntxiv nrog rau cov tshuaj insulin tsis kam, lub cev qhov hnyav.

Thaum kuaj xyuas qhov sib npaug ntawm Combogliz thiab nws cov khoom sib xyaw, metformin thiab saxagliptin, nws tau muab tawm tias tsis muaj kev sib txawv hauv cov khw muag tshuaj ntawm cov tshuaj, kev sib xyaw ntawm ob yam tshuaj hauv ib ntsiav tshuaj tsis ua rau tsis zoo rau ib qho twg ntawm lawv, cov nyhuv ntawm ntshav qab zib yog zoo ib yam.

Nyob rau tib lub sijhawm, cov tshuaj sib txuam ua ke tau pom tias muaj txiaj ntsig zoo dua li noj tib cov tshuaj sib cais. Qhov no yog vim muaj qhov nce ntxiv ntawm qhov yuav ua raws li kev kho, lo lus txhais tau tias ua tau raws li txhua tus kws kho mob cov tshuaj. Hauv cov kab mob mus ntev, xws li mob ntshav qab zib mellitus, nws yog ib txwm muaj qis: cov neeg mob tsis nco qab noj lwm lub tshuaj, lossis lawv cia li tso tseg tsis noj ib qho tshuaj uas tau hais tseg. Kev tshawb fawb pom tias qhov kev kho mob yooj yim dua, ua rau tus kws kho mob muaj peev xwm ua tiav. Qhov kev hloov ntawm metformin thiab saxagliptin cais mus rau Combogliz Prolong tso cai rau ntxiv txo glycated hemoglobin los ntawm 0.53%.

Tau ntau xyoo, nws yog metformin uas tau pom zoo los ntawm cov koom haum kho mob ntshav qab zib yuav tsum tau sau tseg rau hauv thawj qhov chaw. Qhov no yog vim qhov tseeb tias metformin ua rau qhov tseem ceeb ntawm hyperglycemia hauv hom 2 ntshav qab zib - insulin tsis kam. Raws li cov lus qhia, glycemia txo ntshav qab zib tshwm sim vim:

• kev tiv thaiv cov piam thaj ntau ntau hauv lub cev (gluconeogenesis, kom tsawg dua - glycogenolysis),
• ua rau kom tsis txhob nqus ntawm cov piam thaj hauv cov hnyuv,
• nce kev ua haujlwm ntawm cov kua dej hauv cov ntaub so ntswg, tshwj xeeb tshaj yog cov leeg.

Qhov ua tau zoo ntawm kev txo qis ntshav qab zib cov tshuaj feem ntau yog soj ntsuam los ntawm kev poob hauv glycated hemoglobin thaum lawv noj. Txog metformin, qhov ntsuas no tseem heev - 1-2%. Cov tshuaj yog qhov nruab nrab nrog rau qhov hnyav; dhau 10 xyoo ntawm kev tswj hwm, qhov nce nruab nrab ntawm cov neeg mob ntshav qab zib yog 1 kg, uas tsawg dua nrog kev kho nrog insulin thiab sulfonylurea derivatives.

Hmoov tsis zoo, kev kho mob nrog metformin tsis yog ib txwm ua tau vim nws cov kev mob tshwm sim - lub plab tsis xis nyob, raws plab, mob sawv ntxov. Txhawm rau txhawm rau txhim kho qhov ua siab ntev ntawm cov tshuaj, nws tau pib tso rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog hloov kho (txuas ntxiv) tso. Nws yog cov metformin uas tau muaj nyob hauv Comboglize Prolong. Cov ntsiav tshuaj muaj tus qauv tshwj xeeb: cov tshuaj nquag tso rau hauv lub txhoj uas nqus dej. Tom qab kev tswj hwm, lub matrix hloov mus rau hauv ib lub gel, uas ua rau kom muaj kev ncua sijhawm tsis xws luag ntawm metformin los ntawm nws mus rau hauv cov ntshav. Kev txo qis qab zib cov txiaj ntsig yog ncua ntev hauv txoj hauv kev no txog 24 teev, yog li cov lus qhia rau kev siv pom zoo kom noj cov ntsiav tshuaj ib hnub ib zaug.

Saxagliptin

Qhov sib xyaw ua ke ntawm Comboglize Prolong yog lub luag haujlwm rau kev txhim kho insulin synthesis. Tus txheej txheem ntawm kev ua ntawm saxagliptin yog qhov kev txwv tsis pub rau lub enzyme DPP-4, lub luag haujlwm ntawm qhov ntawd yog qhov tshwm sim ntawm cov nce zuj zus. Tus incretins yog tsim tawm nrog nce glycemia thiab txhawb kev nce siab hauv kev tsim cov tshuaj insulin endogenous. Yog tias koj ua kom qeeb ntawm cov nyhuv ntawm DPP-4, ntau dua qub yuav ua haujlwm ntev dua, insulin synthesis yuav nce siab, ntshav qabzib yuav poob qis.

Qhov kom zoo ntawm cov tshuaj yog kev sib raug zoo ntawm cov piam thaj mus rau hauv cov ntshav thiab cov tshuaj insulin. Derivatives ntawm sulfonylurea tsis muaj kev sib raug zoo li ntawd. Txawm hais tias siv tshuaj ntau dua, saxagliptin tsis tuaj yeem txuas lub neej ntawm incretins ntau dua 2 zaug, yog li nws cov ntshav qab zib cov txiaj ntsig tsawg tsawg hauv lub sijhawm thiab kev coj ua tsis ua rau lub qog ntshav qab zib. Tsis yog ib qho txaus ntshai txo cov piam thaj thaum lub sijhawm nws siv tau raug kaw tseg. Tus cwj pwm ceev faj ntawm saxagliptin rau beta hlwb tsim cov tshuaj insulin tso cai ntev lawv cov kev ua haujlwm thiab ncua sijhawm teem sijhawm kho cov tshuaj insulin, uas yog kev tsis pom qab rau hauv cov ntshav qab zib mellitus.

Ob qho metformin thiab saxacgliptin qeeb rau kev nkag mus ntawm cov kua nplaum los ntawm lub plab hnyuv mus rau hauv cov hlab ntsha. Raws li cov neeg mob ntshav qab zib, ob qho tshuaj yuav txo qhov qab los noj mov thiab ua kom muaj kev txaus siab, yog li Combogliz Prolong yog qhov kev xaiv zoo tshaj plaws rau cov neeg mob nyhav dhau los, hauv kev sib piv rau cov tshuaj sib xyaw ua ke ntawm metformin nrog sulfonylurea.

Tsuas yog drawback ntawm saxagliptin yog nws tus nqi, uas yog ib qho kev txiav txim ntawm qhov ntau dua li pheej yig sulfonylurea npaj.

Ntu Cheebtsam

Ntxiv rau cov tshuaj yeeb dej caw, Combogliz Prolong ntsiav tshuaj tseem muaj cov khoom ntxiv uas pab txhawb kev tsim khoom thiab muab lub sijhawm ntev ntawm metformin. Ua ib feem ntawm sab hauv, lossis matrix, magnesium stearate, hypromellose, carmellose. Cov ntsiav tshuaj muaj peb lub plhaub taum Opadrai, suav nrog talc, titanium oxide, macrogol. Sab saum toj txheej muaj zas - hlau oxide.

Cov tshuaj sib txawv sib txawv hauv cov xim: 2.5 + 1000 mg daj, 5 + 500 beige, 5 + 1000 paj yeeb. Rau txhua lub ntsiav tshuaj, tsim nyog qhov tshuaj yog thov pleev xim xiav.

Ntu cov khoom xyaw tau tawm ua ke nrog cov quav hauv daim ntawv ntawm qhov muag, nws tuaj yeem nqa daim ntawv sau ua ntsiav tshuaj. Hauv cov pawg no tsis muaj ntau yam hauv lub siab.

Lub txee lub neej ntawm Comboglize Prolong yog 3 xyoos. Tus tsim khoom lag luam tsuas xav tau kev tswj cia yog qhov kub txog li 30 qib.

Tus nqi ntawm kev ntim khoom yog los ntawm 3150 txog 3900 rubles. nyob ntawm seb muaj pes tsawg ntawm cov tshuaj hauv ib pob (28 lossis 56 pcs.) thiab ntau npaum li cas.

Cov kev cai rau kev noj cov tshuaj

Qhov pom zoo zoo tshuaj txhua hnub ntawm saxagliptin rau feem ntau cov ntshav qab zib yog 5 mg. Ib koob tshuaj me dua ntawm 2.5 mg yog kho rau lub raum tsis ua haujlwm nrog GFR tsawg dua 50, zoo li thaum noj qee yam tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob uas ua rau muaj kev nce siab ntau ntawm saxagliptin hauv cov ntshav.

Kev noj cov tshuaj metformin raug xaiv ib tus zuj zus raws li qib ntawm cov tshuaj insulin. Rau thawj ib nrab ntawm lub hlis, cov neeg mob ntshav qab zib haus 1 ntsiav tshuaj muaj 5 + 500 mg.

Thaum pib ntawm kev kho, qhov kev pheej hmoo ntawm phiv ntawm metformin yog qhov ntau tshwj xeeb. Txhawm rau txo lawv, cov tshuaj tau coj nruj nruj nrog zaub mov, nyiam dua thaum yav tsaus ntuj. Yog tias cov tshuaj metformin muaj kev tiv thaiv zoo, tom qab 2 lub lis piam nws cov koob tshuaj tau nce mus txog 1000 mg. Saxagliptin yog qaug cawv ntawm tib yam tshuaj. Yog tias muaj qhov tsis zoo nyob hauv txoj hnyuv, qhov kev muab tshuaj yuav tsum tau muab ncua thiab muab sij hawm ntxiv rau lub cev kom tau siv cov tshuaj. Yog tias glycemia yog qhov qub, Combogliz Prolong tuaj yeem siv rau tib lub sij hawm ntau xyoo yam uas tsis tas yuav ua kom poob txiaj ntsig.

Qhov siab tshaj uas tau tso cai ntawm Comboglize yog 5 + 2000 mg. Nws yog muab los ntawm 2 ntsiav tshuaj ntawm 2.5 + 1000 mg, lawv haus cawv tib lub sijhawm. Yog tias 2000 mg ntawm metformin rau cov ntshav qab zib tsis txaus, lwm 1000 mg tuaj yeem noj nyias, zoo dua rau tib daim ntawv ntev (Glucofage Ntev thiab analogues: Formin Ntev, Metformin MV, thiab lwm yam).

Txhawm rau kom ntseeg tau yam tsis ua haujlwm ntawm cov nquag, cov tshuaj tau qaug rau tib lub sijhawm. Txhawm rau khaws cia lub caij nyoog ntev, cov ntsiav tshuaj tsis tuaj yeem tsoo.

Yuav hloov hloov Combogliz Prolong li cas

Generics hauv Combogliz Prolong tsis tuaj kawm ntawv thiab yuav tsis tshwm sim rau yav tom ntej, vim tias patent tseem muaj tshuaj los ntawm cov tshuaj. Pab pawg neeg analogues yog linagliptin gliptins (kev sib xyaw nrog metformin yog tsim los hauv cov khoom lag luam Gentadueto), vildagliptin (Galvus Met ua ke nrog tshuaj), sitagliptin (Velmetia, Yanumet). Lawv cov txiaj ntsig nyob rau hauv cov ntshav qab zib mellitus yog ze rau saxagliptin, tab sis cov tshuaj sib txawv hauv cov tshuaj, pharmacokinetics, contraindications, yog li kev hloov mus rau cov tshuaj tshiab yuav tsum pom zoo nrog kws kho mob.

Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm lub koom haum ntawm Diabetology - Tatyana Yakovleva

Kuv tau kawm qhov teeb meem mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.

Kuv maj nrawm los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj hwm los tsim cov tshuaj uas kho cov mob ntshav qab zib mellitus kom zoo. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.

Lwm qhov xov xwm zoo: Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau txais kev nyab xeeb qhov kev saws me nyuam ntawm cov haujlwm tshwj xeeb uas them rau cov nqi tshuaj ntau. Hauv Lavxias, neeg mob ntshav qab zib kom txog thaum lub Tsib Hlis 18 (suav nrog) tuaj yeem tau txais nws - Tsuas yog 147 rubles!

Yuav txuag tau nyiaj li cas ntawm Combogliz Prolong:

1. "Sau" Combogliz Prolong los ntawm Onglisa thiab Metformin. Onglisa - cov tshuaj ntawm tib cov chaw tsim tshuaj, muaj 2.5 lossis 5 mg ntawm saxagliptin. Nws tus nqi yog 1800 rubles. rau 30 ntsiav tshuaj ntawm 5 mg. Txhawm rau kom ua tiav cov lus sib xyaw ua ke ntawm Combogliz Prolong, ib qho tshuaj tiv thaiv ntev ntev ntxiv rau Ongliz, nws yuav raug nqi 250-750 rubles ib hlis.
2. Nug koj tus kws kho mob txog tshuaj pub dawb rau saxagliptin. Cov tshuaj yuav tseem tsis tau muaj nyob hauv txhua thaj chaw, tab sis lawv cov lej tau nce txhua xyoo. Kev taw qhia rau kev teem caij ntawm saxagliptin - ua rau lub cev tsis muaj ntshav lossis ntshav ntau heev ntawm sulfonylurea. Vim tias cov tshuaj tsis muaj cov tshuaj ua kom pheej yig, lub tsev muag tshuaj yuav muab koj li qub Combogliz Prolong ntsiav tshuaj, lossis metformin thiab Onglizu.
3. Yog tias koj xaj cov tshuaj hauv khw muag tshuaj online thiab khaws nws tus kheej los ntawm qhov teeb meem, koj tuaj yeem txuag tau li 10% ntawm nws cov nqi.

Hloov mus rau sulfonylurea derivatives yog qhov tsis xav tau vim tias lawv tuaj yeem ua rau mob ntshav qab zib. Yog tias tsis muaj lwm txoj kev xaiv, nws yog qhov zoo dua los coj qhov kev nyab xeeb ntawm glimepiride thiab gliclazide. Analogues ntawm cov tshuaj Combogliz nrog cov tshuaj no - Amaril M, Glimecomb.

Kev ntsuas rau siv

Raws li cov lus qhia, Combogliz Prolong ntsiav tshuaj tau sau rau cov ntshav qab zib hom 2, yog tias kev kho cov zaub mov thiab kev ua haujlwm lub cev tsis txaus txo cov glycemia. Muab tus nqi siab ntawm cov tshuaj, nws qhov kev txiav txim siab yog me ntsis kom nqaim dua. Raws li endocrinologist, lawv muab tshuaj rau hauv cov teebmeem hauv qab no:

1. Yog hais tias tus neeg mob tau txo qis tshuaj insulin, thiab noj sulfonylurea yog contraindicated.
2. Nrog rau kev pheej hmoo siab ntawm cov ntshav qog ntshav: cov neeg laus, cov ntshav qab zib nrog cov kab mob sib xyaw ua ke thiab kev txwv kev noj zaub mov, cov neeg mob uas muaj lub siab ntawm kev tawm dag zog, ua haujlwm ntawm kev ua haujlwm uas yuav tsum tau mob siab rau.
3. Cov neeg mob ntshav qab zib uas ib txwm tsis ua raws li kws kho mob cov lus qhia yuav tsis nco qab noj tshuaj lossis noj mov raws sijhawm.
4. Tus mob ntshav qab zib nrog neuropathy uas tau ua rau cov tsos mob ntawm tus mob ntshav qab zib tsawg.
5. Yog tias tus neeg mob ntshav qab zib siv tag nrho nws lub zog yuav tsum zam kom tsis txhob hloov mus rau insulin. Nws ntseeg tias sulfonylurea tuaj yeem ua kom sai ntawm kev rhuav tshem cov beta hlwb. Tsis muaj cov ntaub ntawv zoo li no hais txog sacasagliptin.

Cov Yuav Tsum Muaj

Daim ntawv ntawm contraindications hauv cov lus qhia rau Comboglyz Prolong yog qhov dav heev, zoo li nrog rau kev siv tshuaj:

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj no tsuas muaj rau hauv cov qauv ntsiav tshuaj. Hauv qhov tsos, cov ntsiav tshuaj zoo ib yam li tsiav tshuaj dog dig. Lawv txhua tus tau npog nrog lub plhaw tiv thaiv tshwj xeeb. Lub xim yuav nce raws qhov ntau npaum. Cov ntsiav tshuaj daj tau muaj 1000 mg ntawm metformin thiab 2.5 mg ntawm saxagliptin. Cov ntsiav tshuaj pink muaj qhov sib npaug ntawm cov metformin, tab sis twb muaj 5 mg ntawm saxagliptin. Cov xim xim daj ntawm cov tsiav tshuaj qhia tau tias lawv muaj 500 mg ntawm metformin thiab 5 mg ntawm saxagliptin.

Cov tshuaj no tsuas muaj rau hauv cov qauv ntsiav tshuaj. Hauv qhov tsos, cov ntsiav tshuaj zoo ib yam li tsiav tshuaj dog dig. Lawv txhua tus tau npog nrog lub plhaub thaiv tshwj xeeb.

Cov ntsiav tshuaj tau ntim rau hauv cov hlwv tshwj xeeb. Hauv ib ntawm lawv, 7 units. Ib daim npav cardboard tuaj yeem nyob ntawm 4 txog 8 rau cov hlwv. Ntxiv rau, txhua pob yuav tsum muaj cov lus qhia ntxaws ntxiv rau kev siv.

Pharmacological kev txiav txim

Cov tshuaj muaj cov nyhuv sib koom ua ke. Txhua lub tebchaw dhia ua ke tawm hauv lawv cov kev hloov kho yooj yim.

Qhov muaj pes tsawg leeg noj tshuaj muaj 2 yam kev tiv thaiv uas txuam nrog kev sib txuam.

Metformin yog qhov zoo tshaj plaws loj loj. Muaj peev xwm ua kom tiav txhua yam kev ua haujlwm ntawm gluconeogenesis. Qhov no ua rau qeeb qis ntawm oxidation ntawm cov rog thiab ua rau ntau qhov rhiab ntawm insulin receptors. Cov xuv pib siv cov piam thaj. Cov tshuaj yeeb dej caw tsis cuam tshuam rau qhov kev txiav txim ntawm cov kua dej hauv cov ntshav thiab tsis ua rau cov ntshav qog ntshav.

Vim tias qhov kev cuam tshuam ntawm metformin, glycogen synthesis yog ua kom tiav. Qhov hloov pauv thiab kev nqus ntawm cov piam thaj hauv cov ntshav nce ntxiv. Nyob rau tib lub sijhawm, qhov nqus ntawm cov piam thaj hauv qab ntawm cov hnyuv txo qis, vim tias ib tus neeg poob sai sai. Cov khoom ntawm cov ntshav tau hloov kho ntau dua.

Saxagliptin txhawb kev tsim cov tshuaj hormones nce ntxiv. Hauv qhov no, qhov kev tso tawm ntawm cov tshuaj insulin los ntawm beta hlwb ntawm cov txiav txiav nce ntxiv, thiab kev tsim tawm ntawm glucagon txo qis dua. Cov piam thaj nyob rau hauv tsawg dua thaum noj mov thiab ntawm lub plab khoob. Vim tias qhov kev txiav txim ntawm cov lus sib txuas, qhov kev xav ntawm lub siab tsis ploj mus ntev, uas muaj txiaj ntsig rau qhov hnyav ntawm cov neeg mob ntshav qab zib.

Cov Tshuaj Pharmacokinetics

Saksagliptin feem ntau hloov tag nrho rau ib hom metabolite.Metformin ua rau tsis muaj qhov hloov pauv ntawm lub cev. Cov tshuaj tawm los tom qab lub raum lim.

Txoj kev kho yuav tsum yog qhov dav thiab ua kom muaj txiaj ntsig nrog kev noj haus thiab ua kom lub cev sib zog.

Qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw hauv cov hlab ntshav yog pom 7 teev tom qab noj tshuaj.

Nrog saib xyuas

Nrog rau kev ceev faj, cov tshuaj yuav tsum tau noj rau cov neeg muaj kab mob plawv. Tus neeg sawv cev hypoglycemic no ua rau muaj kev pauv hloov lub raum. Yog li, cov neeg muaj daim siab mob thiab lub raum hloov pauv thaum thawj cov kev mob tshwm sim yuav tsum kho cov tshuaj ntau npaum li cas rau qhov tsawg kawg nkaus.

Yuav ua li cas noj Combogliz Prolong

Qhov ntau npaum li cas rau txhua tus neeg mob yog xaiv hauv cov nruj me ntsis ib leeg. Txhua yam nws nyob ntawm qhov mob hnyav ntawm tus neeg mob thiab kev noj qab haus huv dav dav.

Cov kws kho mob pom zoo kom noj cov tshuaj no ib hnub ib zaug.

Nws raug nquahu kom ua qhov no tib lub sijhawm ntawm hnub ntawd. Capsules tsis tom, lawv yuav tsum nqos tag nrho thiab ntxuav nrog dej huv.

Thaum pib kho, yam tsawg kawg nkaus tau raug kho. Yog tias tsim nyog, nws tau nce siab ntxiv kom txo qhov kev pheej hmoo ntawm kev tsim cov kev mob tshwm sim uas tsis xav tau. Qhov ntau npaum ntau tau muab faib ua ib zaug thiab rov ua ntau dua.

Nrog ntshav qab zib

Rau kev kho mob ntshav qab zib, ib ntsiav tshuaj ib hnub yog tsim nrog. Qhov no cuam tshuam loj heev rau kev mloog zoo ntawm cov piam thaj hauv cov ntshav, tshem tawm cov cim ntawm insulin tsis txaus hauv lub cev. Thaum thawj cov tsos mob ntawm intoxication tshwm sim nrog cov tshuaj, koj yuav tsum kho nws cov tshuaj ntau npaum li cas lossis tsis siv kiag li.

Capsules tsis tom, lawv yuav tsum nqos tag nrho thiab ntxuav nrog dej huv.

Sab sij huam

Cov cuab yeej muaj ntau yam contraindications rau siv. Yog tias koj tsis ua raws li tag nrho cov cai rau kev siv tshuaj, cov kev phiv tshuaj tsis zoo yuav tshwm sim:

• mob taub hau heev
• mob taub hau
• teeb duab kos hauv plab
• cov txheej txheem sib kis uas tshwm sim hauv cov kabmob ntawm cov kab mob genitourinary,
• raws plab, xeev siab thiab ntuav,
• mob hlab ntsws
• o ntawm qis qis dua thiab ntsej muag,
• ntshav qab zib,
• kev ua xua nyob rau hauv daim ntawv ntawm urticaria,
• mob ncauj plab thiab kab mob ntsws,
• flatulence
• ua txhaum ntawm saj kev xav ntawm cov zaub mov.

Teeb duab kev mob hauv plab, raws plab, xeev siab thiab ntuav tuaj yeem yog cov tsos mob tshwm sim ntawm cov tshuaj.

Tag nrho cov tsos mob no tuaj yeem tshem tawm nrog kev pab cuam ntawm kev kho mob. Lawv kuj ploj lawm tom qab ua tiav kev tshem tawm ntawm cov tshuaj.

Siv thaum cev xeeb tub thiab lactation

Thaum lub sij hawm nqa tus me nyuam, kev siv tshuaj tsis pom zoo. Qhov no yog vim qhov tseeb tias tsis muaj cov kev tshawb fawb soj ntsuam txaus ua pov thawj tias qhov tshuaj tsis ua rau pom cov embryogenic thiab teratogenic cov yam ntxwv. Nws tuaj yeem cuam tshuam qhov tsim ntawm tus me nyuam. Yog li no, thaum cev xeeb tub, thaum muaj xwm txheej ceev, nws zoo dua los hloov tus neeg mob mus rau tshuaj insulin.

Tsis muaj pov thawj dabtsi txog seb cov tshuaj kis mus rau leej niam mis. Yog li, yog tias tsim nyog, kev kho zoo li ntawd zoo dua kom tsis pub lactation.

Siv rau lub sijhawm qub

Cov tshuaj yuav tsum yog kho nrog kev saib xyuas zoo rau cov neeg laus laus. Lawv muaj kev pheej hmoo loj tshaj plaws ntawm kev tsim cov kev mob tshwm sim, yog li thaum thawj cov tsos mob ntawm intoxication tshwm sim, koj yuav tsum mus ntsib tus kws kho mob txhawm rau kho qhov tshuaj lossis txiav tawm cov tshuaj kom tag.

Qee cov kws kho mob tau sau tshuaj rau cov tshuaj noj kom tsis qab los ua kom tau qhov chaw zoo kom ua rau cov kab mob hauv lub siab ntawm cov neeg laus.

Noj ntau dhau

Overdose yog tsawg. Tab sis yog tias koj huam yuaj ntau dua qhov tshuaj, cov kab mob lactic acidosis yuav tshwm sim:

• ua pa tsis ua hauj lwm
• mob leeg
• tsaug zog thiab chim siab,
• cramping thiab mob plab
• hnov tsw ntawm acetone los ntawm lub qhov ncauj.

Nrog rau kev tsim cov kev mob nyhav, tus neeg mob tau pw tsev kho mob thiab lim ntshav yog qhov yuav tsum tau ua. Tej zaum qhov kev txhim kho ntawm hypoglycemia. Nrog nws cov teeb meem me, cov zaub mov qab zib pab. Hauv daim ntawv loj, ib tus neeg yuav tsum tau coj mus rau kev nco qab thiab muab nws txhaj tshuaj glucagon lossis txoj kev daws teeb meem ntawm dextrose hydrochloride.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv sib xyaw nrog qee cov isoenzymes ua rau nce siab ntawm lactate hauv cov ntshav ntshav.

Cov tshuaj tuaj yeem txhim kho qhov nqis tes ntawm cov tshuaj:

• magnesium thiab txhuas hydroxide,
• Rifampicin,
• nicotinic acid
• cov thyroid hormones thiab estrogens,
• tshuaj kho mob
• calcium ion blockers,
• Isoniazid.

Kev ua tau zoo ntawm cov tshuaj hauv qab no yog txo qis:

• ethanol
• Furosemide
• Ketoconazole,
• Famotidine
• Glibenclamide,
• Erythromycin,
• Verapamil
• Fluconazole

Tus kws kho mob tshwj xeeb yuav tsum paub txog txhua yam tshuaj uas tus neeg mob tau noj txhawm rau txhawm rau kho kho txoj kev siv tshuaj kho kom raug.

Tus kws kho mob tshwj xeeb yuav tsum paub txog txhua yam tshuaj uas tus neeg mob tau noj txhawm rau txhawm rau kho kho txoj kev siv tshuaj kho kom raug.

Cawv tau zoo

Nws tsis tsim nyog yuav haus cawv rau cov neeg muaj ntshav qab zib. Yog tias muaj tshuaj ethan nyob rau hauv ib qho tshuaj twg uas tau siv, nco ntsoov qhia koj tus kws kho mob ntawm qhov no thiab tau txais cov lus pom zoo rau kev kho mob ntxiv.

Cov qauv zoo tib yam sib xws yog:

• Janumet
• Galvus Met,
• Combogliz
• Glibomet,
• Bagomet.

Nqe rau Combogliz Prolong

Tus nqi yog li ntawm 3 txhiab rubles. Tus nqi kawg tsuas yog tsuas yog nyob ntawm lub khw muag tshuaj muaj npoo thiab cov naj npawb ntawm cov ntsiav tshuaj hauv pob.

Ib qho piv txwv ntawm Combogliz Prolong tuaj yeem yog Yanumet, ntsiav tshuaj rau kev kho mob ntawm cov neeg mob ntshav qab zib mellitus.

Kev tshuaj xyuas ntawm cov neeg mob txog Comboglize ntev

Alisa, 38 xyoo, St. Petersburg: “Tsis ntev los no lawv kuaj tus kab mob ntshav qab zib mellitus. Tus kws kho mob sau tshuaj, tab sis lawv tsis pab, tus mob tsuas muaj mob zuj zus. Hloov los ntawm Combogliz Prolong. Cov nyhuv tau dhau los ua tsis tus. Cov tshuaj pab ua kom cov ntshav qab zib nyob hauv siab tsis pub tshaj. Kuv tsis muaj kev phiv dab tsi. Tsuas yog thaum pib ntawm kev siv muaj tus me ntsis kiv taub hau thiab xeev siab. Yoo txaus dhau. Cov tshuaj tseem kim. "

Valery, 52, Kazan, “Lawv tau muab tshuaj kho mob ntshav qab zib. Txaus siab nrog qhov kev txiav txim. Cov ntshav qabzib sai sai rov qab los. Tab sis kuv tsis tuaj yeem noj nws ntev, vim hais tias tus nqi ntawm cov tshuaj ntau dhau. Ntau yam phiv. Muaj kev pheej tsaug zog, tsis xis nyob. Lub taub hau tas li, muaj mob zawv plab heev. Tus kws kho mob tau hais tias nws yog hom tshuaj uas xaiv, thiab qhia kuv kom hloov nws nrog lwm yam tshuaj. "

Yuri, 48 xyoo, Saratov: “Cov tshuaj tau los. Txaus siab nrog qhov kev txiav txim. Nws poob ceeb thawj zoo, tab sis tsis tuaj yeem tswj hwm qhov hnyav. Cov tshuaj tau pabcuam nrog rau cov teebmeem no. Lub xeev ntawm cov kev ua kom mob plawv tseem tau zoo dua. Ntawm qhov tshwm sim tsis zoo, tsuas muaj mob raws plab thiab tsuas kiv taub hau me ntsis. Tab sis txhua yam mus yam tsis muaj kev cuam tshuam txog kev kho mob uas tsis tsim nyog. ”

Cov kws kho mob tshuaj xyuas

Alexander, endocrinologist Alexander, Moscow: “Feem ntau tib neeg tau sau tshuaj kho rau kev kho mob yam mob ntshav qab zib thib ob. Kev txheeb xyuas cov khoom sib txawv. Tus nqi ntawm cov ntsiav tshuaj yog siab. Nov yog ib qho ntawm kev cuam tshuam loj tshaj. Hauv feem ntau cov neeg mob, qhov tsis xav tau sab tshwm sim, uas qee tus ploj mus lawv tus kheej, thaum lwm tus neeg yuav tsum tau kho qhov tshuaj kho lossis ua tiav qhov tsis txaus siv tshuaj. Yog li ntawd, Kuv yog tus tsis ntseeg txog Combogliz Prolong. Tab sis cov tshuaj muaj nqis nws cov nqi. ”

Yaroslav, tus kws kho mob endocrinologist, St. Petersburg: “Kuv tau siv cov tshuaj ntev los tswj cov qib qab zib kom zoo rau cov neeg mob ntshav qab zib hom 2. Muaj ntau tus neeg mob tsis txaus siab. Ua ntej ntawm tag nrho cov tib neeg muaj qhov ncaj ncees ntau ntawm cov kev mob tshwm sim, uas yog twb tau ua tsis zoo. Hauv qee cov neeg mob, cov tsos mob ntawm intoxication yog li hais tias yuav tsum detoxification kho los yog lim ntshav yuav tsum tau.

Tab sis kuj tseem muaj cov neeg mob uas cov tshuaj pab tau zoo. Lawv cov suab thaj theem thiab qhov hnyav tau khaws cia nyob hauv cov theem ib txwm siv mus ntev ntev. Yog li, Kuv ib txwm qhia tshuaj rau cov neeg mob ua cov tshuaj xaiv. ”

Cov chaw muag tshuaj

Combogliz Prolong yog cov piam thaj txo cov tshuaj ntawm cov chav kawm biguanide, uas muaj cov khoom sib xyaw xws li metformin thiab saxagliptin monohydrate, uas muaj cov txiaj ntsig zoo rau txo qis ntshav qabzib. Cov tshuaj yog siv rau kev kho mob ntshav qab zib mellitus qib ob hauv cov menyuam yaus hnub nyoog ntau dua kaum xyoo, thiab cov neeg laus muaj hnub nyoog tsis txog 60 xyoo. Ib qho tshuaj tsis pom zoo rau cov poj niam uas tau xeeb menyuam, nrog rau cov niam uas saib xyuas tus mob txhawm rau kom zam dhau qhov kev pheej hmoo ntawm kev tsim kab mob hauv tus menyuam.

Cov tshuaj yog siv los kho li mob hlwb lossis hauv txoj kev kho mob. Daim ntawv ntawm kev kho mob, ntau npaum li cas, thiab tseem siv sijhawm los ntawm chav kawm yog txiav txim los ntawm tus kws kho mob koom nrog tom qab ua kev soj ntsuam, khaws kev sim, tsim kom muaj cov duab hauv lub chaw kuaj mob tseeb, suav txog tus yam ntxwv ntawm lub cev thiab tus neeg mob lub hnub nyoog.

Pharmacological cov teebmeem ntawm saxagliptin

Kev tivthaiv yuav pab txo qis ntshav ntshav ntawm tus neeg mob. Nws muaj peev xwm los thaiv cov kev ua ntawm dipeptidyl peptidase-4 inhibitors thiab ua kom ntev ntawm kev ua haujlwm ntawm glucagon-zoo li peptide-1 thiab lub plab hnyuv twm polypeptide. Ntxiv rau, cov tshuaj tsub kom nce tus naj npawb ntawm glucagon-zoo li peptide-1 thiab lub plab zom mov polypeptide hauv lub cev. Tom qab kis tus kab mob rau hauv feem, qhov ntsiab lus ntawm cov piam thaj hauv cov ntshav tau txo qis. Kev noj cov tshuaj tuaj yeem txo qhov kev pheej hmoo ntawm kev tsim teeb meem insulin.

Pharmacological cov teebmeem ntawm metformin

Metformin, uas yog ib feem ntawm cov tshuaj, yog ib yam tshuaj tiv thaiv kab mob kev nkeeg. Nws ua tau zoo tiv thaiv cov ntshav qabzib hauv tus neeg mob cov ntshav, tsis cuam tshuam rau lub plab zom mov. Cov tshuaj muaj peev xwm ua kom hnov ​​qab cov suab thaj hauv cov tshuaj los ntawm cov khoom tsis muaj carbohydrate hauv lub siab. Qhov feem cuam ua rau cov piam thaj hauv cov ntshav tom qab yoo mov lossis noj mov. Vim qhov kev nqis tes ua ntawm cov feem, cov piam thaj pib ua kom zoo dua los ntawm lub cev thiab kev txhim kho metabolism hauv lub cev. Kev noj cov tshuaj tsis ua rau cov neeg mob raug kev txom nyem los ntawm cov tshuaj insulin los ntawm lub cev tsis txaus, ua rau cov ntshav qab zib qis dua qhov tau teev tseg, uas tuaj yeem ua rau lub zog tuag tshaib hauv lub cev.

Qhov zoo ntawm kev kho mob nrog Combogliz Prolong: