Gensulin N (Gensulin N)

Dosage daim ntawv ntawm Gensulin N - kev ncua rau kev tswj hwm subcutaneous (s / c): kev tshem tawm dawb, ib qho kev sib cais uas cais mus rau hauv cov nag lossis daus thaum so thiab xim tsis muaj xim lossis yuav luag tsis muaj xim supernatant, nrog maj mam tshee, cov txo yuav nrawm dua (3 ml hauv cartridges, ib lub cell contour ntim ntawm 5 daim cartridges, 1 ntim rau hauv cov thawv ntawv cardboard, 10 ml ib leeg hauv cov hwj pob tshab iav uas tsis muaj xim, 1 lub raj mis hauv pob ntawv cardboard).

Kev sib xyaw rau 1 ml ntawm kev rho tawm:

• cov tshuaj nquag: insulin-isophan recombinant tib neeg - 100 IU,
• Cov khoom siv pabcuam: phenol, glycerol, metacresol, protamine sulfate, sodium hydrogen phosphate dodecahydrate, zinc oxide, hydrochloric acid, dej rau kev txhaj tshuaj.

Kev ntsuas rau siv

Gensulin N raug pom zoo rau siv nyob rau hauv hom 1 mob ntshav qab zib mellitus, nrog rau hom 2 mob ntshav qab zib mellitus nyob rau theem ntawm kev tsis kam rau hypoglycemic tus neeg sawv cev rau kev siv lub qhov ncauj, ib feem tawm tsam cov tshuaj no (nyob rau hauv kev kho mob sib xyaw ua ke) thiab cov kab mob sib kis.

Tsuas tshuaj thiab tswj hwm

Kev ncua lub Gensulin N yog npaj rau kev tswj hwm sc.

Tus kws kho mob txiav txim siab qhov ntau npaum li cas ntawm cov tshuaj hauv txhua kis raws li kev ntsuas ntawm cov ntshav qabzib, thiab coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob. Qhov nruab nrab txhua hnub koob tshuaj txawv nyob hauv thaj tsam ntawm 0.5-1 IU ib 1 kg ntawm tus neeg mob qhov hnyav.

Qhov kev txhaj tshuaj yog nyiam dua nyob hauv tus ncej puab, nws tseem raug tso cai los qhia cov tshuaj mus rau hauv lub pob tw, sab xub ntiag lub plab lossis daim nyias nyias ntawm lub xub pwg. Qhov chaw txhaj tshuaj hauv cheeb tsam anatomical yuav tsum tau hloov pauv kom tsis txhob muaj qhov mob lipodystrophy.

Thaum nplawm qhov ncua kev kawm ntawv, lub vial los yog daim cartridge yuav tsum tsis txhob muab lub zog pov tseg, vim tias qhov no yuav ua rau cov npuas dej ua rau lub zog, ua rau nws nyuaj rau teeb tsa koob tshuaj. Cov tsos ntawm cov tshuaj hauv vials thiab cartridges yuav tsum tau kuaj xyuas tsis tu ncua yog tias flakes nyob rau hauv qhov ncua kev kawm lossis cov khoom dawb yog pom tias tau ua raws hauv qab / phab ntsa ntawm lub vial lossis daim cartridge, tsim cov nyhuv ntawm te, nws yuav tsum tsis txhob siv.

Qhov ntsuas kub ntawm kev txhaj tshuaj yuav tsum haum rau chav tsev kub.

1. Txheem tawv nqaij nrog cawv ntawm qhov chaw txhaj tshuaj.
2. Siv ob tug ntiv tes los khawm thaj tsam tawv nqaij.
3. Ntxig lub koob ntawm lub kaum ntawm 45 ° rau hauv lub hauv paus ntawm quav thiab txhaj insulin hauv qab daim tawv nqaij.
4. Tom qab kev txhaj tshuaj ntawm tsawg kawg 6 vib nas this, tsis txhob tshem tawm rab koob kom paub tseeb tias cov tshuaj tau siv tshuaj puv nkaus.
5. Yog tias cov ntshav pom ntawm qhov chaw txhaj tshuaj tom qab tshem rab koob, maj mam nias nws nrog koj tus ntiv tes.
6. Qhov chaw txhaj tshuaj yuav tsum tau hloov pauv.

Gensulin N yog siv los ua lub tshuaj monotherapy thiab ua ib feem ntawm cov kev kho mob nyuaj nrog cov yeeb yam luv luv (Gensulin P).

Tus neeg mob yuav tsum paub txog cov tswv yim ntawm kev siv tshuaj, nyob ntawm qhov xwm txheej hauv qab.

Kev siv ntawm kev ncua nyob hauv vials

Siv ib hom tshuaj insulin:

1. Tshem tawm cov txhuas tiv thaiv lub hau ntawm lub vial.
2. Txheeb rau lub hnab roj hmab rau ntawm lub thauv.
3. Sau cov cua mus rau hauv cov phwj hauv qhov ntim coj los ntsuas qhov yuav tsum tau siv ntawm cov tshuaj insulin thiab qhia cov huab cua mus rau hauv lub vial.
4. Tig lub ntsej muag nrog lub koob txhaj tshuaj txhaj tshuaj thiab sau cov koob yuav tsum tau ntawm cov tshuaj insulin rau hauv nws.
5. Tshem tawm cov koob txhaj tshuaj ntawm lub khob, tshem tawm cov cua ntawm lub koob txhaj tshuaj, thiab paub tseeb tias qhov yuav tsum tau siv cov tshuaj insulin.
6. Ua ib qho kev txhaj tshuaj.

Kev siv ob hom tshuaj insulin:

1. Tshem tawm cov txhuas tiv thaiv kaus mom los ntawm vials.
2. Txheem kua roj hmab kom zoo ntawm daim ntaub.
3. Tam sim ntawd ua ntej hu, yob ib lub vias ntawm cov kua dej ntawm lub sij hawm nruab nrab (ntev) kev txiav txim hauv daim ntawv ntawm kev ncua ntawm lub xib teg ntawm txhais tes kom txog thaum cov txo mus rau tusyees faib thiab cov ntawv dawb huab ncua kev.
4. Sau cov pa mus rau hauv cov phwj hauv qhov ntim uas sib xyaw rau qhov yuav tsum tau siv ntawm cov insulin ntev ntev, qhia huab cua rau hauv lub thauv nrog rau kev ncua, thiab tom qab ntawd tshem tawm rab koob.
5. Tso cov huab cua rau hauv cov koob txhaj tshuaj hauv lub ntim sib xyaw rau qhov yuav tsum tau txhaj ntawm cov tshuaj insulin luv luv, qhia huab cua rau hauv lub vias ntawm cov tshuaj insulin nyob rau hauv daim ntawv ntawm cov tshuaj ntshiab, tig lub vial nrog cov koob txhaj tshuaj ntxeev tiaj thiab sau cov koob uas yuav tsum tau.
6. Tshem tawm cov koob txhaj tshuaj ntawm lub khob, tshem tawm cov cua ntawm lub koob txhaj tshuaj, thiab paub tseeb tias qhov yuav tsum tau siv cov tshuaj insulin.
7. Ntxig lub koob txhaj rau hauv lub thauv nrog lub ncua kev kawm, tig lub thauv nrog lub koob txhaj tshuaj kus sab saud thiab sau qhov xav tau ntawm cov tshuaj insulin ntev.
8. Tshem tawm rab koob ntawm lub vial, tshem tawm cov cua ntawm lub koob txhaj tshuaj, thiab xyuas yog tias tag nrho cov tshuaj insulin tsim nyog.
9. Ua ib qho kev txhaj tshuaj.

Nws yog ib qho tseem ceeb uas yuav tsum tau ntaus cov tshuaj insulin hauv kab uas hais los saud.

Kev siv kev tshem tawm hauv cov cartridges

Daim cartridges nrog cov tshuaj Gensulin N yog npaj rau siv tsuas yog siv cov phwj leeg ntawm lub tuam txhab "Owen Mumford". Yuav tsum ua raws li cov lus teev tseg hauv cov lus qhia rau kev siv cov phwj syringe rau kev siv tshuaj insulin.

Ua ntej siv Gensulin H, lub cartridge yuav tsum raug kuaj xyuas thiab paub tseeb tias tsis muaj kev puas tsuaj (tej daim, tawg); yog tias lawv nyob, yuav siv tsis tau daim cartridge. Tom qab kev txhim kho lub taub ntim hauv daim ntawv syringe, ib txoj hlua xim yuav tsum pom ntawm lub qhov rai ntawm tus tuav.

Ua ntej kev txhim kho lub taub ntim hauv daim ntawv syringe, nws yuav tsum tau tig mus thiab nqis kom lub pob iav me me sab hauv sib tov. Cov txheej txheem tig rov qab ua dua tsawg kawg 10 zaug, kom txog rau thaum huab cua dawb thiab zoo li qub huab ncua kev kawm. Ua ib txoj kev txhaj tshuaj tom qab ntawd.

Yog tias daim cartridge raug teeb tsa hauv lub npiv ua ntej, kev sib xyaw cov kev ncua ntawv yog nqa tawm rau tag nrho cov kab ke (tsawg kawg 10 zaug) thiab rov ua dua ua ntej txhua qhov kev txhaj tshuaj.

Tom qab ua tiav ntawm kev txhaj, koob yuav tsum tau sab laug hauv qab daim tawv nqaij tsawg kawg yog 6 feeb, thiab yuav tsum tuav lub pob nyem kom txog thaum rab koob tawm ntawm daim tawv nqaij tag. Qhov no yuav xyuas kom meej tias lub koob tshuaj tau muab rau kev tswj kho kom raug thiab txwv qhov muaj feem ntshav / lymph nkag mus rau hauv rab koob lossis insulin cartridge.

Daim cartridge nrog cov tshuaj Gensulin N tsuas yog npaj rau tus kheej nkaus xwb thiab tsis tuaj yeem sau kom tau.

Sab sij huam

• cov txiaj ntsig ntawm kev cuam tshuam ntawm cov metabolism hauv kev noj haus: kev mob ntshav qab zib ntau - mob taub hau, blanching ntawm daim tawv nqaij, palpitations, nce tawm hws, tshee, ntxhov siab, kev tshaib kev nqhis, kab mob plab hauv lub qhov ncauj, vim qhov mob ntshav qab zib tsawg, ntshav qab zib tsis tuaj yeem yuav tshwm sim,
• kev tsis haum lub cev: tsis tshua pom tshwm - ua pob rau ntawm daim tawv nqaij, Quincke's edema, tsis tshua muaj tshwm sim - anaphylactic ceeb,
• kev hloov pauv ntawm thaj chaw txhaj tshuaj: o thiab khaus, hyperemia, thaum siv sijhawm ntev - lipodystrophy ntawm thaj chaw txhaj tshuaj,
• Lwm yam: kab mob edema, qhov hloov pauv sai sai (feem ntau thaum pib ntawm chav kawm ntawm txoj kev kho).

Cov tsos mob ntawm kev noj haus ntau tshaj yuav yog qhov kev loj hlob ntawm lub qog ntshav qab zib. Txog kev kho mob ntawm qhov mob me, nws raug nquahu kom noj qab zib lossis zaub mov ntau nyob rau hauv carbohydrates. Cov neeg mob ntshav qab zib yuav tsum nqa suab thaj, qab zib, ncuav qab zib, lossis haus dej qab zib txhua hnub.

Thaum muaj teeb meem loj hauv cov piam thaj hauv qab siab, thaum tsis nco qab lawm, 40% kev daws teeb meem yog muab tshuaj pleev, glucagon yog muab cov tshuaj intramuscularly, tso ntshav los yog subcutaneously. Tom qab rov qab nco qab, nws raug nquahu kom noj cov khoom noj uas muaj cov khoom noj carbohydrate kom tiv thaiv kev rov qab ua kom muaj ntshav qab zib.

Cov lus qhia tshwj xeeb

Gensulin N raug txwv tsis pub siv yog tias qhov kev ncua txim tsis tig dawb thiab tusyees turbid tom qab co.

Thaum ua kev kho cov tshuaj insulin, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam kom tsis tu ncua qib ntawm cov piam thaj hauv cov ntshav. Cov kev tshuaj xyuas zoo li no yog qhov tsim nyog vim tias, ntxiv rau kev noj tshuaj insulin ntau dhau, qhov ua rau cov ntshav qog ntshav ntshav tuaj yeem yog: hla kev noj mov, hloov cov tshuaj, raws plab, ntuav, ua kom lub cev muaj zog ntau ntxiv uas txo qhov xav tau cov kab mob insulin (lub raum / nplooj siab tsis ua haujlwm, hypofunction ntawm adrenal cortex, lub qog ua haujlwm lossis lub caj pas pituitary), hloov pauv chaw txhaj tshuaj, cuam tshuam nrog tshuaj nrog lwm cov tshuaj.

Kev noj tshuaj yuam kev ntau dhau los yog tawg ntawm cov tshuaj insulin, tshwj xeeb tshaj yog nyob rau cov neeg mob ntshav qab zib hom 1, tuaj yeem ua rau hyperglycemia. Feem ntau, cov tsos mob pib ntawm hyperglycemia pib maj mam, dhau ob peb teev lossis hnub. Lub qhov ncauj qhuav, nqhis dej, xeev siab, ntuav, kiv taub hau, liab thiab qhuav ntawm daim tawv nqaij, tsis qab los, tsis hnov ​​tsw, tsis hnov ​​ntxhiab ntawm cov acetone hauv kev ua pa, ua kom tso zis tawm. Yog hais tias kev kho mob tsis nqa tawm, tom qab ntawd nrog hom 1 ntshav qab zib mellitus, hyperglycemia tuaj yeem ua rau txoj kev loj hlob ntawm lub neej muaj sia - ntshav qab zib ketoacidosis.

Kho cov koob tshuaj insulin yog qhov yuav tsum tau ua rau hypopituitarism, kev ua haujlwm ntawm lub qog ua haujlwm lub qog, Addison tus kab mob, mob siab / mob raum, nrog rau cov neeg laus laus dua 65 xyoos.

Qhov xav tau koob tshuaj insulin kuj tseem yuav tsum tau ua kom tau nrog kev siv dag zog ntawm lub cev lossis kev hloov pauv ntawm lub cev ib txwm muaj.

Qhov xav tau ntawm insulin yog nce los ntawm cov kab mob sib kis, tshwj xeeb ntawm kev kis, thiab cov mob uas muaj nrog kub taub hau.

Txoj kev hloov ntawm ib hom tshuaj insulin mus rau lwm tus kuj yuav tsum tau ua, tswj cov theem ntawm cov piam thaj hauv cov ntshav.

Nws yog ib qho tseem ceeb uas yuav tsum xav txog tias kev siv cov tshuaj insulin txo cov neeg mob lub siab ntev rau cawv.

Kev siv Gensulin N hauv kev tsim cov tshuaj insulin tsis pom zoo vim yog qhov tseem los nag lossis daus ntawm qhov raug tshem tawm hauv qee qhov kev cuam tshuam.

Kev mob ntshav nce siab yuav ua rau tus neeg mob tsis muaj peev xwm mloog thiab txo qis ntawm lub hlwb kev xav, uas yuav ua rau muaj kev pheej hmoo thaum tsav tsheb thiab / lossis ua haujlwm nrog lwm cov txheej txheem sib xyaw.

Yeeb tshuaj sib cuam tshuam

• hypoglycemic agents rau qhov ncauj cov thawj coj, inhibitors ntawm monoamine oxidase (Mao) inhibitors, angiotensin converting enzyme (ACE) inhibitors, uas tsis yog-xim β-blockers, carbonic anhydrase inhibitors, bromocriptine, sulfonamides, tetracyclines, octreotide, anabolic steroids, clofibrate, mebendazole, ketoconazole, theophylline, pyridoxine, cyclophosphamide, kev npaj lithium, fenfluramine, kev npaj muaj ethanol: txhim kho cov nyhuv hypoglycemic ntawm insulin,
• thiazide diuretics, glucocorticosteroids (GCS), tshuaj tiv thaiv qhov ncauj, cov thyroid hormones, sympathomimetics, heparin, tricyclic antidepressants, clonidine, danazole, diazoxide, calcium channel blockers, phenytoin, morphine, nicotine: cov nyhuv hypoglycemic tsis muaj zog.
• reserpine thiab salicylate: tuaj yeem ua rau ob qho kev ua kom tsis muaj zog thiab txhim kho kev ua ntawm insulin.

Cov qauv ntawm Gensulin N yog: Biosulin N, Vozulim N, Insuman Bazal GT, Insuran NPH, Protamine-insulin Xwm Ceev, Protafan NM, Protafan NM Penfill, Rinsulin NPH, Rosinsulin S, Humodar B 100 Rec.

Cov Cai Siv Tshuaj So

Tso tawm los ntawm kev kho mob.

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Ntau lab tus kab mob tau yug, ciaj thiab tuag hauv peb lub plab. Lawv tuaj yeem pom tsuas yog txhawb nqa siab, tab sis yog tias lawv tuaj ua ke, lawv yuav haum rau hauv lub khob kas fes.

Muaj ntau cov kev kho mob nthuav tawm heev, xws li kev siv khoom tsis nco qab ntawm cov khoom. Hauv plab ntawm ib tus neeg mob uas tau mob los ntawm tus txiv neej no, 2500 cov khoom txawv teb chaws tau pom.

Txhua tus neeg muaj tsis tsuas yog nyias tus ntiv tes, tab sis kuj hais lus.

Txhawm rau hais txawm tias cov lus luv thiab yooj yim, peb siv 72 leeg leeg.

Hauv tebchaws Askiv, muaj txoj cai lij choj raws li uas tus kws phais neeg tuaj yeem tsis kam ua haujlwm rau tus neeg mob yog tias nws haus luam yeeb lossis rog dhau. Ib tus neeg yuav tsum tso tawm tus cwj pwm tsis zoo, thiab tom qab ntawd, tej zaum, nws yuav tsis xav tau kev phais mob.

Cov tshuaj hnoos "Terpincode" yog ib tus thawj coj hauv kev muag, tsis muaj vim tias nws muaj tshuaj.

Cov kws kho hniav tau tshwm sim tsis ntev los no. Rov qab rau hauv lub xyoo pua puv 19, nws yog lub luag haujlwm ntawm tus kws tu plaub hau kom rub tawm cov hniav mob.

Qhov kub siab tshaj plaws ntawm lub cev tau sau cia ntawm Willie Jones (USA), uas tau nkag rau hauv tsev kho mob nrog qhov kub txog 46,5 ° C.

Yog tias koj lub siab ua haujlwm, kev tuag yuav tshwm sim hauv ib hnub.

Cov tshuaj muaj npe zoo "Viagra" tau tsim thaum chiv thawj los kho kev mob ntshav siab los ntawm arterial tawg.

Tus mob uas tsis tshua muaj mob yog Kuru's kab mob. Tsuas yog cov neeg sawv cev ntawm pawg neeg Fore hauv New Guinea mob nrog nws. Tus neeg mob tuag ntawm kev luag. Nws ntseeg tau tias qhov ua rau tus mob yog noj tib neeg lub hlwb.

Cov kws tshawb fawb Asmeskas tau sim cov nas thiab tau xaus lus tias cov kua txiv mab txiv ntoo txwv tsis pub muaj kev txhim kho ntawm cov hlab ntshav atherosclerosis ntawm cov hlab ntshav. Ib pawg nas haus dej dawb, thiab lub thib ob ua kua txiv. Raws li qhov tshwm sim, cov hlab ntsha ntawm cov pab pawg thib ob yog pub dawb cov plahaum roj.

Nrog kev mus saib xyuas lub txaj tanning, txoj kev pheej hmoo ntawm kev mob qog tawv nqaij yuav nce 60%.

Tib neeg cov ntshav "khiav" los ntawm cov hlab ntsha hauv qab qhov siab, thiab yog tias nws txoj kev ncaj ncees tau ua txhaum, nws tuaj yeem tua txog 10 meters.

Peb lub raum tuaj yeem ntxuav peb liv cov ntshav hauv ib feeb.

Ib nrab ntawm cov hniav tsis txaus los yog ua tiav adentia tuaj yeem yog qhov tshwm sim ntawm kev raug mob, caries lossis kab mob pos hniav. Txawm li cas los xij, hniav ploj tuaj yeem hloov nrog cov hniav cuav.

Nosological kev faib tawm (ICD-10)

Cov Tshuaj Hauv Tshuaj

Gensulin H - insulin cov tib neeg tau siv cov thev naus laus zis DNA sib luag. Nws yog kev ua haujlwm nruab nrab insulin. Nws cuam tshuam nrog ib qho kev tshwj xeeb nyob rau sab nraud cytoplasmic ntawm lub hlwb thiab tsim cov txheej txheem insulin receptor complex uas ua rau cov txheej txheem ua tiav, suav nrog synthesis ntawm cov lej ntawm cov enzymes tseem ceeb (suav nrog rau hexokinase, pyruvate kinase, glycogen synthetase). Qhov txo qis hauv cov ntshav qab zib yog vim suav nrog nce nws txoj kev thauj mus los ntawm qhov tsis txaus, txhim kho cov nqaij ua kom zoo dua qub thiab ua kom zoo ntxiv, ua kom lub cev lipogenesis, glycogenogenesis, thiab txo qis npaum li cov piam thaj tsim tawm los ntawm lub siab.

Lub sijhawm ntawm kev ua ntawm insulin npaj feem ntau vim yog tus nqi ntawm kev nqus, uas nyob ntawm ntau yam (piv txwv, koob tshuaj, hom thiab qhov chaw ntawm kev tswj hwm), thiab yog li cov ntaub ntawv ntawm kev txiav txim ntawm insulin yog raug rau qhov txawv txav, ob qho tib si hauv tib neeg thiab tib neeg Cov.

Nkaus profile nrog kev txhaj tshuaj subcutaneous (kwv yees cov nuj nqis): qhov pib ntawm kev ua tom qab 1.5 teev, qhov ua tau zoo tshaj plaws yog nyob hauv qhov sib nrug ntawm 3 thiab 10 teev, lub sijhawm ua haujlwm tau ntev txog 24 teev.

Cov Tshuaj Pharmacokinetics

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm los ntawm qhov chaw txhaj tshuaj (mob plab, ncej puab, pob tw), ntau npaum li cas (ntim ntawm cov tshuaj insulin), qhov concentration ntawm cov tshuaj insulin hauv cov tshuaj. Nws tau faib qhov tsis sib luag thoob plaws cov ntaub so ntswg: nws tsis nkag rau ntawm qhov chaw tiv thaiv kab mob thiab nkag mus rau niam mis. Nws yog rhuav tshem los ntawm insulinase, feem ntau yog nyob hauv daim siab thiab lub raum. Nws yog tawm los ntawm ob lub raum (30-80%).

Kev sib txuam

Cov nyhuv hypoglycemic ntawm insulin yog txhim kho los ntawm qhov ncauj hypoglycemic, MAO inhibitors, ACE inhibitors, carbonic anhydrase inhibitors, tsis-xaiv β-adrenergic thaiv cov khoom ua haujlwm, bromocriptine, octreotide, sulfanilamides, anabolic steroids, tetracyclin, phenofphindonindinininofofindindindindindindindindindindindindindindin npaj muaj ethanol.

Cov tshuaj tiv thaiv tsis haum, tshuaj corticosteroids, cov thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin, nicotine tsis muaj zog tiv thaiv cov ntshav ua kom tsis muaj zog.

Nyob rau hauv kev cuam tshuam ntawm reserpine thiab salicylates, ob qho tib si ua rau qaug zog thiab nce ntxiv hauv kev ua ntawm cov tshuaj muaj peev xwm ua tau.

Tsuas tshuaj thiab tswj hwm

S / c hauv tus ncej puab. Kev hno tuaj yeem tuaj yeem ua rau hauv anterior plab phab ntsa, pob tw, lossis thaj tsam ntawm deltoid leeg ntawm lub xub pwg.

Nws yog ib qho tsim nyog yuav tsum hloov chaw txhaj tshuaj nyob rau thaj tsam anatomical thiaj li tiv thaiv kev txhim kho ntawm lipodystrophy.

Cov koob tshuaj ntawm cov tshuaj tau txiav txim siab los ntawm tus kws kho mob tshwj xeeb hauv txhua kis, raws li theem ntawm cov piam thaj hauv cov ntshav. Qhov nruab nrab, qhov kev siv tshuaj txhua hnub los ntawm 0.5 mus rau 1 IU / kg (nyob ntawm tus neeg qhov yam ntxwv ntawm tus neeg mob thiab theem ntawm cov piam thaj hauv cov ntshav).

Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov.

Gensulin N tuaj yeem siv tau ib leeg lossis ib qho ua ke nrog luv luv ua yeeb yam insulin (Gensulin P).

Noj ntau dhau

Cov tsos mob hypoglycemia yog ua tau.

Kev Kho Mob: tus neeg mob tuaj yeem tshem tawm qhov mob ntshav qab zib me me los ntawm kev noj cov suab thaj lossis cov khoom noj uas muaj carbohydrate. Yog li, nws tau pom zoo rau cov neeg mob ntshav qab zib kom nqa cov piam thaj, qab zib, ncuav qab zib lossis kua txiv qab zib nrog lawv.

Hauv cov teeb meem loj, thaum tus neeg mob poob siab, ib qho 40% dextrose daws yog siv tus kab mob, i / m, s / c, iv glucagon. Tom qab nws rov qab nco qab, tus neeg mob tau pom zoo kom noj cov khoom noj uas muaj cov khoom noj carbohydrate kom tiv thaiv kev rov qab txhim kho hypoglycemia.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Cov muaj tswv yim: m-cresol - 1.5, phenol - 0.65 mg, glycerol - 16 mg, protamine sulfate - 0.27 mg, zinc oxide - 30 μg, disodium hydrogen phosphate dodecahydrate - 5.04 mg, hydrochloric acid 0.1M - 0.03 ml.

3 ml - cartridges hauv syringe cwjmem (5) - hlwv (1) - thawv ntawv thawv.
10 ml - fwj (1) - thawv ntawv thawv.

Pharmacological kev txiav txim

Tib neeg siv tshuaj insulin DNA insulin. Nws yog cov insulin ntawm lub sijhawm ua haujlwm ntev. Regulates ntshav qabzib metabolism, muaj cov teebmeem anabolic. Hauv cov leeg nqaij thiab lwm cov nqaij (muaj qhov tsis suav ntawm lub hlwb), cov roj ntsha insulin thauj cov ntshav qabzib thiab amino acids ntau dua, thiab txhim kho cov protein anabolism. Insulin txhawb kev hloov pauv ntawm cov piam thaj rau glycogen hauv lub siab, inhibits gluconeogenesis thiab txhawb kev hloov pauv ntawm cov piam thaj rau cov rog.

Cov Tshuaj txiav txim

Nruab nrab-insulin. Txo cov concentration ntawm cov piam thaj hauv cov ntshav, ua rau nws nqus tau los ntawm cov ntaub so ntswg, txhim kho lipogenesis thiab glycogenogenesis, synthesis protein, txo cov nqi ntawm cov piam thaj los ntawm daim siab. Nws cuam tshuam nrog ib qho kev tshwj xeeb ntawm sab nraud daim nyias nyias ntawm cov hlwb thiab ua ib qho insulin receptor complex. Qhov kev txo qis hauv cov ntshav qab zib yog tshwm sim los ntawm kev nce ntxiv hauv nws txoj kev thauj mus los hauv lub cev, qhov kev nqus thiab pov tseg ntau ntawm cov nqaij mos, qhov kev txhawb nqa ntawm lipogenesis, glycogenogenesis, synthesis protein, txo tus nqi ntawm cov piam thaj los ntawm lub siab (txo qis glycogen tawg), thiab lwm yam. Tom qab txhaj tshuaj subcutaneous, cov nyhuv tshwm sim hauv 1-2 teev. cov nyhuv nyob hauv lub sij hawm nruab nrab ntawm 2-12 teev, lub sijhawm ua ntawm -18-24 teev, nyob ntawm lub cev muaj pes tsawg leeg ntawm insulin thiab qhov tshuaj, qhov cuam tshuam tseem ceeb ntawm kev cuam tshuam ntawm tus kheej thiab sab hauv. Kev nqus thiab pib ntawm kev ua yog nyob ntawm txoj kev tswj hwm (sc lossis intramuscularly), qhov chaw nyob (plab, ncej, pob tw) thiab qhov ntim ntawm qhov kev txhaj tshuaj, qhov tob ntawm cov tshuaj insulin nyob rau hauv cov tshuaj, thiab lwm yam Nws tau faib tsis ncaj nyob rau hauv cov ntaub so ntswg, tsis nkag rau hauv lub cev placental thiab hauv siab mis nyuj. Nws yog rhuav tshem los ntawm insulinase, feem ntau yog nyob hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum.

Kev siv yeeb tshuaj

Hom 2 mob ntshav qab zib mellitus, hom 2 mob ntshav qab zib mellitus, theem ntawm kev tawm tsam cov tshuaj tiv thaiv ntshav qab zib hauv qhov ncauj, ib feem tawm ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib (kev kho ua ke), cov kab mob sib kis, kev phais mob (mono- lossis kev sib txuas ua ke), mob ntshav qab zib mellitus thaum cev xeeb tub (yog tias txoj kev noj zaub mov tsis muaj txiaj ntsig. )

Ntau yam phiv

Kev tsis haum tshuaj (urticaria, angioedema - ua npaws, ua tsis taus pa, ntshav tsawg), ntshav tsis txaus, ua rau lub ntsej muag tawv nqaij, tawm hws, tawm hws, tshee, tshee tshee, tshaib plab, ntxhov siab, ntxhov siab, mob plab hauv lub qhov ncauj, mob taub hau, tsaug zog, pw tsaug zog, pw tsaug zog kev ntshai, kev ntxhov siab, chim siab, tus cwj pwm txawv, tsis ruaj ntseg ntawm kev txav, hais lus thiab tsis pom kev), hypoglycemic coma, hyperglycemia thiab ntshav qab zib acidosis (ntawm cov koob tshuaj qis, hla kev txhaj tshuaj, tsis ua raws li kev noj zaub mov, ntawm e ua npaws thiab kis tau tus mob): nkees nkees, nqhis dej, tsis qab los noj mov, ntsej muag ntsej muag), lub siab tsis hnov ​​qab (mus txog rau ntawm lub cev ntas tsis xeev thiab tsis nco qab lawm), qhov pom kev tsis pom kev zoo (feem ntau thaum pib kho), txhaj tshuaj tiv thaiv kab mob nrog tib neeg cov tshuaj insulin, nce titer ntawm cov tshuaj tiv thaiv insulin. nrog rau kev nce ntxiv hauv glycemia, hyperemia, khaus thiab lipodystrophy (mob atrophy lossis hypertrophy ntawm subcutaneous rog) ntawm qhov chaw txhaj tshuaj. Thaum pib ntawm kev kho, qhov ntws thiab cuam tshuam kev ntshaus siab (yog ib ntus thiab ploj mus nrog kev kho mob txuas ntxiv).

Kev sib txuam

Cov tshuaj tsis sib haum nrog kev daws teeb meem ntawm lwm cov tshuaj. Cov nyhuv hypoglycemic yog txhim kho los ntawm sulfonamides (suav nrog qhov ncauj tshuaj hypoglycemic, sulfonamides), MAO inhibitors (suav nrog furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, tshuaj tsis-steroidal anti-inflammatory tshuaj (suav nrog) anabolic steroids (suav nrog stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, Li + kev npaj, pyridoxine, quininine, quinine. Cov nyhuv hypoglycemic yog tsis muaj zog los ntawm glucagon, somatropin, glucocorticosteroids, tshuaj tiv thaiv qhov ncauj, estrogens, thiazide thiab lev diuretics, BMCC, thyroid hormones, heparin, sulfin pyrazone, sympathomimetics, danazole, tricyclic antidepressants, calcinone, diacidone, calcium calcium chloride, antioxidant antioxidant epinephrine, blockers ntawm H1-histamine receptors. Beta-blockers, reserpine, octreotide, pentamidine tuaj yeem txhim kho ob qho tib si thiab ua rau cov nyhuv tsis muaj zog hypoglycemic ntawm insulin.

Koob tshuaj thiab cov qauv ntawm daim ntawv thov

Hloov pauv, 1-2 zaug hauv ib hnub, 30-45 feeb ua ntej noj tshais (hloov chaw txhaj tshuaj txhua zaus). Hauv qee kis tshwj xeeb, tus kws kho mob tuaj yeem sau ntawv txhaj tshuaj rau cov leeg nqaij. Kev tswjhwm ntawm insulin ntawm ib nrab sijhawm yog txwv tsis pub! Cov koob tshuaj raug xaiv ib tus zuj zus thiab nyob ntawm cov ntsiab lus ntawm cov piam thaj hauv cov ntshav thiab zis, cov yam ntxwv ntawm chav kawm ntawm tus kabmob. Feem ntau, koob tshuaj yog 8-24 ME 1 sijhawm nyob rau ib hnub. Hauv cov neeg laus thiab menyuam yaus uas muaj lub siab tsis txaus siab rau insulin, qhov koob tshuaj tsawg dua 8 IU / hnub yuav txaus, rau cov neeg mob uas tsis tshua hnov ​​mob ntau dua - ntau dua 24 IU / hnub. Ntawm qhov tshuaj txhua hnub ntau dua 0.6 IU / kg, - nyob rau hauv daim ntawv ntawm 2 koob nyob hauv qhov chaw sib txawv. Cov neeg mob tau txais 100 ME lossis ntau dua toj ib hnub, thaum hloov cov tshuaj insulin, nws raug nquahu kom mus pw hauv tsev kho mob. Hloov pauv los ntawm ib qho tshuaj rau lwm tus yuav tsum tau ua nyob rau hauv kev tswj hwm ntawm cov ntshav qabzib.

Daim ntawv tso tawm, ntim thiab muaj pes tsawg leeg Gensulin N

Kev rau txim rau s / c tswj hwm ntawm cov xim dawb, thaum sawv tus dawb nag lossis daus thiab xim tsis muaj xim lossis yuav luag tsis muaj xim zoo nkauj tau tsim, qhov nag lossis daus tau yooj yim resuspended nrog maj mam tshee.

Tshwjxeeb: metacresol - 1.5 mg, phenol - 0.65 mg, glycerol - 16 mg, protamine sulfate - 0.27 mg, zinc oxide - txog 40 μg Zn 2+ / 100 ME, sodium hydrogen phosphate dodecahydrate - 5.04 mg, hydrochloric acid - q.s. txog pH 7.0-7.6, dej d / i - txog 1 ml.

3 ml - cartridges (5) - contour cell ntim.
10 ml - fwj (1) - pob khoom los ntawm cardboard.

Kev taw qhia ntawm cov tshuaj Gensulin N

• ntshav qab zib hom 1
• hom 2 mob ntshav qab zib mellitus: theem ntawm kev tawm tsam ntawm qhov ncauj hypoglycemic, ib nrab tsis kam rau cov tshuaj no (thaum kho sib txuam), kab mob sab.

Kev noj tshuaj ntxiv

Gensulin N yog npaj rau kev tswj hwm sc. Cov koob tshuaj ntawm cov tshuaj tau txiav txim siab los ntawm tus kws kho mob tshwj xeeb hauv txhua kis, raws li theem ntawm cov piam thaj hauv cov ntshav. Qhov nruab nrab, cov tshuaj txhua hnub ntawm cov tshuaj yog li 0.5 mus rau 1 IU / kg lub cev qhov hnyav (nyob ntawm tus neeg qhov yam ntxwv ntawm tus neeg mob thiab theem ntawm cov ntshav qab zib).

Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov.

Gensulin H ib txwm txhaj tshuaj sc rau hauv tus ncej puab. Kev hno tuaj yeem tuaj yeem ua rau hauv pem hauv ntej lub plab phab ntsa, pob tw, lossis thaj tsam ntawm deltoid leeg ntawm lub xub pwg.

Nws yog ib qho tsim nyog yuav tsum hloov chaw txhaj tshuaj nyob rau thaj tsam anatomical thiaj li tiv thaiv kev txhim kho ntawm lipodystrophy.

Gensulin N tuaj yeem pom ob qho tib si thiab nyob rau hauv kev sib xyaw nrog luv luv ua yeeb yam insulin (Gensulin P).

Cov lus qhia yuav muab rau tus neeg mob

Cov txheej txheem txhaj tshuaj rau insulin hauv vials

Yog tias tus neeg mob siv tsuas yog ib hom tshuaj insulin

1. Ua kom cov roj hmab membrane rau ntawm lub thawb.

2. Tso cov huab cua rau hauv cov koob txhaj tshuaj kom txog qhov yuav tsum tau txhaj rau cov tshuaj insulin. Tshaj tawm huab cua rau hauv lub vial ntawm insulin.

3. Tig lub khob nrog lub taub hau ntxeev tiaj thiab kos cov koob xav tau ntawm cov tshuaj insulin rau hauv cov phwj. Tshem tawm cov koob txhaj tshuaj ntawm lub khob thiab tshem tawm cov cua los ntawm kab mob. Kuaj seb qhov tshuaj insulin puas raug.

4. hno tam sim ntawd.

Yog tias tus neeg mob xav tau ob hom tshuaj insulin sib xyaw

1. Ua kom cov roj hmab puas tsuaj rau ntawm cov iav.

2. Tam sim ntawv ua ntej hu, yob ib fwj tshuaj insulin ("pos huab") nruab nrab ntawm koj xib teg kom txog thaum cov tshuaj insulin hloov tusyees dawb thiab huab.

3. Ncuav cov cua tso rau hauv cov koob txhaj tshuaj ib zaug npaum li uas tau txhaj rau cov tshuaj insulin rau huab. Ntxig huab cua rau hauv cov vias insulin vial thiab tshem tawm cov koob ntawm lub vial.

4. Kos cua rau hauv lub taub dej hauv ib qho kom haum rau cov koob tshuaj tiv thaiv luv luv ("pob tshab"). Tshaj tawm cov huab cua mus rau hauv lub raj mis kom paub meej ntawm insulin. Tig lub khob nrog lub taub hau ntxeev tiaj thiab hu lub koob xav tau ntawm cov tshuaj insulin. Tshem tawm cov koob tawm thiab tshem tawm cov cua ntawm lub koob txhaj tshuaj. Kuaj qhov tseeb.

5. Muab rab koob tso rau hauv lub khob nrog cov insulin "pos huab", tig lub khob nrog lub koob txhaj tshuaj kauv sab hauv thiab ntaus lub koob xav tshuaj. Tshem tawm cov cua hauv lub koob txhaj tshuaj thiab xyuas seb qhov koob tshuaj muaj tseeb li cas. ចាក់ cov tshuaj insulin sib tov tam sim ntawd.

6. Ib txwm ntaus tshuaj insulin rau hauv tib theem ib yam li tau piav saum toj no.

Kev Tsim Tshuaj Cartridge

Lub cartridge nrog cov tshuaj Gensulin N yog npaj rau siv tsuas yog siv cov phwj syringe los ntawm Owen Mumford (Great Britain). Tus neeg mob yuav tsum tau txais kev ceeb toom txog qhov yuav tsum tau ua tib zoo ua raws li cov lus qhia hauv cov lus qhia rau kev siv tshuaj xau rau kev siv tshuaj insulin.

Ua ntej siv, nco ntsoov tias tsis muaj kev puas tsuaj (piv txwv li, cov kab nrib pleb) rau ntawm daim cartridge nrog kev npaj Gensulin N. Tsis txhob siv lub taub hau ntawv yog tias pom muaj kev puas tsuaj. Tom qab daim cartridge tso rau hauv tus cwj mem syringe, ib txoj hlua xim yuav tsum pom ntawm lub qhov rais ntawm tus sau daim cartridge.

Ua ntej muab daim cartridge tso rau hauv tus cwj mem, tig lub pob hauv taub thiab sau kom lub pob iav txav ntawm qhov kawg mus rau qhov kawg ntawm lub taub hau. Qhov txheej txheem no yuav tsum tau ua dua tsawg kawg 10 zaug kom txog thaum txhua lub kua tau dawb thiab zoo li huab. Tom qab qhov no, ib qho kev txhaj tshuaj yog qhov tsim nyog.

Yog tias daim cartridge twb dhau hauv lub tes tsho hauv lub taub hau, koj yuav tsum tig nws nrog lub taub ntim hauv sab hauv thiab nce tsawg kawg 10 zaug. Qhov txheej txheem no yuav tsum rov qab ua ntej txhua txoj kev txhaj tshuaj.

Tom qab txhaj, koob yuav tsum nyob twj ywm hauv qab daim tawv nqaij tsawg kawg 6 vib nas this. Khaws lub pob nyem kom txog thaum lub koob raug tshem tawm hauv qab ntawm daim tawv nqaij, yog li ua kom ntseeg tau qhov kev tswj hwm kev noj tshuaj kom raug thiab cov ntshav lossis lymph nkag mus rau hauv rab koob lossis insulin cartridge yog txwv.

Lub taub hau nrog cov tshuaj Gensulin N yog npaj rau kev siv tus kheej nkaus xwb thiab yuav tsum tsis txhob ua kom tiav.

1. Nrog rau ob tug ntiv tes, ntxig daim tawv nqaij, ntxig rab koob rau hauv lub hauv paus ntawm qhov quav ntawm kaum ntawm 45 °, thiab txhaj tshuaj insulin hauv qab daim tawv nqaij.

2. Tom qab txhaj tshuaj, cov koob yuav tsum nyob twj ywm hauv qab daim tawv nqaij tsawg kawg 6 vib nas this, txhawm rau xyuas kom meej tias cov insulin nkag.

3. Yog tias cov ntshav pom ntawm qhov chaw txhaj tshuaj tom qab tshem tawm rab koob, maj mam nias qhov chaw txhaj tshuaj nrog koj tus ntiv tes.

4. Nws yog ib qho tsim nyog yuav tsum hloov chaw txhaj tshuaj.

Sab sij huam

Vim muaj qhov cuam tshuam rau cov metabolism hauv kev ua kom yuag: hypoglycemic tej yam kev mob (pallor ntawm daim tawv nqaij, nce tawm hws, palpitations, tshee tshee, tshaib plab, ntxhov siab, teeb meem hauv lub qhov ncauj, mob taub hau). Kev mob ntshav qog ntshav qis tuaj yeem ua rau txhim kho kev mob hypoglycemic coma.

Kev ua xua: tsis tshua muaj - pob khaus rau ntawm daim tawv nqaij, Quincke's edema, tsis tshua muaj tshwm sim - anaphylactic shock.

Cov tshuaj tiv thaiv hauv zos: hyperemia, o thiab khaus ntawm qhov chaw txhaj tshuaj, nrog rau siv sijhawm ntev - lipodystrophy ntawm thaj chaw txhaj tshuaj.

Lwm yam: kab mob edema, qhov hloov pauv sai sai (feem ntau thaum pib kho).

Cev xeeb tub thiab lactation

Thaum cev xeeb tub, nws yog ib qho tseem ceeb kom tswj tau glycemic zoo hauv cov neeg mob ntshav qab zib. Thaum cev xeeb tub, qhov xav tau rau cov tshuaj insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb.

Nws raug nquahu kom cov neeg mob ntshav qab zib mellitus qhia tus kws khomob txog qhov pib lossis npaj lossis cev xeeb tub.

Hauv cov neeg mob uas mob ntshav qab zib mellitus thaum lactation (pub niam mis), yuav tsum tau txhaj tshuaj kho cov tshuaj insulin, zaub mov noj, lossis ob qho tib si yuav tsum tau ua.

Hauv kev tshawb fawb ntawm kev tshuaj lom neeg caj ces hauv cov tshuaj lom hauv vitro thiab hauv vivo, tib neeg cov tshuaj insulin tsis muaj qhov tshwm sim mutagenic.