Yanumet: analogues, cov lus qhia rau kev siv, muaj pes tsawg leeg thiab tshuaj xyuas
Cov nplooj ntawv no muab cov npe ntawm txhua tus Yanumet cov yeeb yaj kiab sib xyaw ua ke thiab cov ntsiab lus rau kev siv. Cov npe ntawm cov pheej yig analogues, thiab koj kuj tuaj yeem sib piv cov nqi hauv cov khw muag tshuaj.
- Qhov pheej yig tshaj analogue ntawm Yanumet:Glucovans
- Cov khoom noj nrov tshaj plaws ntawm Yanumet:Vipdomet
- Kev faib tawm ATX: Metformin thiab sitagliptin
- Cov khoom xyaw nquag / muaj pes tsawg leeg: metformin, sitagliptin
| # | Npe | Nqe hauv Lavxias | Nqe hauv Ukraine |
|---|---|---|---|
| 1 | Glucovans glibenclamide, metformin Analogue hauv kev taw qhia thiab txoj kev siv | 34 RUB | 8 UAH |
| 2 | Gluconorm Analogue hauv kev taw qhia thiab txoj kev siv | 45 rub | -- |
| 3 | Vipdomet metformin, alogliptin Analogue hauv kev taw qhia thiab txoj kev siv | 55 RUB | 1750 UAH |
| 4 | Combogliz Prolong metformin, saxagliptin Analogue hauv kev taw qhia thiab txoj kev siv | 130 rub | -- |
| 5 | Sinjardi empagliflozin, metformin hydrochloride Analogue hauv kev taw qhia thiab txoj kev siv | 240 rub | -- |
Thaum xam xyuas tus nqi pheej yig analogues yanumet tus nqi yam tsawg kawg nkaus uas tau pom hauv daim ntawv teev tus nqi muab los ntawm cov khw muag tshuaj tau raug coj los suav
| # | Npe | Nqe hauv Lavxias | Nqe hauv Ukraine |
|---|---|---|---|
| 1 | Vipdomet metformin, alogliptin Analogue hauv kev taw qhia thiab txoj kev siv | 55 RUB | 1750 UAH |
| 2 | Gentadueto linagliptin, metformin Analogue hauv kev taw qhia thiab txoj kev siv | -- | -- |
| 3 | Glibomet glibenclamide, metformin Analogue hauv kev taw qhia thiab txoj kev siv | 257 rub | 101 UAH |
| 4 | Avandamet Analogue hauv kev taw qhia thiab txoj kev siv | -- | -- |
| 5 | Velmetia metformin, sitagliptin Analogue nyob rau hauv muaj pes tsawg leeg thiab qhia tau | 6026 rub | -- |
Muab daim ntawv teev cov tshuaj analogues raws li kev txheeb cais ntawm cov tshuaj feem ntau thov
Analogs hauv kev muaj pes tsawg leeg thiab qhia txog kev siv
| Npe | Nqe hauv Lavxias | Nqe hauv Ukraine |
|---|---|---|
| Velmetia metformin, sitagliptin | 6026 rub | -- |
Cov npe saum toj no ntawm cov yeeb tshuaj analogues, uas qhia hloov Yanumet, yog qhov tsim nyog tshaj plaws vim tias lawv muaj tib cov tshuaj sib luag thiab sib luag ua ke raws li kev taw qhia rau kev siv
Analogs los ntawm qhov taw qhia thiab cov qauv ntawm kev siv
| Npe | Nqe hauv Lavxias | Nqe hauv Ukraine |
|---|---|---|
| Amaryl M Limepiride Micronized, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 rub | 101 UAH |
| Glucovans glibenclamide, metformin | 34 RUB | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 rub | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Galvus Met vildagliptin, metformin | 259 RUB | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Comboglize XR metformin, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 rub | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 RUB | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 rub | -- |
Sib txawv muaj pes tsawg leeg, tuaj yeem ua ke nyob rau hauv kev taw qhia thiab cov qauv ntawm daim ntawv thov
| Npe | Nqe hauv Lavxias | Nqe hauv Ukraine |
|---|---|---|
| Avantomed rosiglitazone, metformin hydrochloride | -- | -- |
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 RUB | 15 UAH |
| Globophage xr metformin | -- | 50 UAH |
| Reduxin Met Metformin, Sibutramine | 20 RUB | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 RUB | 12 UAH |
| Tshuaj Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Formin metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Tshuaj hlau Metformin | -- | 20 UAH |
| Tshuaj Metamin SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Tshuaj nyob | 37 RUB | -- |
| Metformin Canon metformin, ovidone K 90, pob kws hmoov txhuv, crospovidone, magnesium stearate, talc | 26 RUB | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Metformin-teva metformin | 43 txhuam | 22 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Yawg Liaj Ua Teb Metformin | -- | -- |
| Glibenclamide Glibenclamide | 30 RUB | 7 UAH |
| Maninyl Glibenclamide | 54 rub | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 rub | 182 UAH |
| Glidiab Glyclazide | 100 tshiav | 170 UAH |
| Lawj Xeeb MR | -- | 92 UAH |
| Kev kuaj mob mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 rub | 44 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Kev Noj Qab Haus Huv Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Kev kuaj mob Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 RUB | -- |
| Amaril | 27 RUB | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Thaj neeb | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Av nplaum glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Raug Tsim | -- | -- |
| Glimepiride glimepiride | 27 RUB | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 RUB | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Glamepiride diamerid | 2 RUB | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 RUB | 895 UAH |
| Onglisa saxagliptin | 1472 RUB | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 rub | 1434 UAH |
| Lixumia lixisenatide | -- | 2498 UAH |
| Guarem Guar cob | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 RUB | 90 UAH |
| Cov Chaw Tshaj Tawm Repaglinide | -- | -- |
| Baeta Exenatide | 150 rub | 4600 UAH |
| Baeta Ntev Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 rub | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 RUB | 3200 UAH |
| Invocana canagliflozin | 13 RUB | 3200 UAH |
| Jardins Empagliflozin | 222 RUB | 566 UAH |
| Trulicity Dulaglutide | 115 RUB | -- |
Yuav ua li cas thiaj nrhiav tau qhov pheej yig tshuaj ntawm cov tshuaj kim?
Txhawm rau kom pom qhov pheej yig cov khoom sib piv rau cov tshuaj, cov dav dav lossis cov lus sau, ua ntej txhua yam, peb pom zoo kom them sai sai rau qhov muaj pes tsawg leeg, uas yog rau tib cov tshuaj nquag thiab qhia tau rau kev siv. Cov tshuaj sib xyaw zoo ib yam ntawm cov tshuaj yuav qhia tau tias cov tshuaj cuam tshuam nrog cov tshuaj, kws tshuaj sib npaug lossis chaw muag tshuaj. Txawm li cas los xij, tsis txhob hnov qab txog qhov ua tsis muaj zog ntawm cov tshuaj uas zoo sib xws, uas tuaj yeem cuam tshuam kev nyab xeeb thiab ua haujlwm. Tsis txhob hnov qab txog cov lus qhia los ntawm cov kws kho mob, kev noj tshuaj rau nws tus kheej tuaj yeem tsim kev puas tsuaj rau koj kev noj qab haus huv, yog li nco ntsoov sab laj rau koj tus kws kho mob ua ntej siv cov tshuaj.
Kev qhia Janumet
LUS QHIA
ntawm kev siv cov tshuaj
YANUMET
Daim ntawv tso tawm
Ntsiav tshuaj
Muaj pes tsawg leeg
1 lub koob ntim-cov roj ntim ua muaj: Sitagliptin phosphate monohydrate 50 mg, Metformin hydrochloride 500, 850 thiab 1000 mg.
Cov neeg siv tshwj xeeb: microcrystalline cellulose 59.30 mg, povidone 48.23 mg, sodium stearyl fumarate 13.78 mg, sodium lauryl sulfate 3.445 mg.
Lub plhaub ntawm Opadray II Cov ntsiav tshuaj liab, 85 F 94203 (17.23 mg) muaj: cov tshuaj cawv polyinyl 47.800%, titanium dioxide (E 171) 6,000%, macrogol - 3350 23.500%, talc 22.590%, dub hlau oxide (E 172) 0.005% hlau oxide liab (E 172) 0.105%.
Ntim
Muaj 14 lub tshuaj nyob hauv lub hlwv. Hauv ib pob ntawv ntawm cardboard 4 blisters.
Pharmacological kev txiav txim
Cov tshuaj Janumet yog kev sib xyaw ntawm ob qhov tshuaj tiv thaiv hypoglycemic nrog kev ua kom tiav (sib ntxiv) cov haujlwm ntawm kev ua, tsim los txhim kho glycemic tswj nyob rau hauv cov neeg mob ntshav qab zib hom 2: sitagliptin, ib qho inhibitor ntawm dipeptidyl peptidase-4 (DPP-4) enzyme, thiab metformin, tus sawv cev ntawm chav kawm biguanide.
Sitagliptin yog qhov ncauj ua kom nquag plias, xaiv DPP-4 ntau heev rau kev kho mob ntshav qab zib hom 2. Cov teeb meem pharmacological ntawm chav kawm ntawm cov tshuaj inhibitors ntawm DPP-4 yog kho kom haum xeeb los ntawm kev ua kom muaj zog ntawm incretins.Los ntawm inhibiting DPP-4, sitagliptin tsub kom qhov siab ntxiv ntawm ob txoj kev ua si nquag ntawm tsev neeg incretin: glucagon-zoo li peptide 1 (GLP-1) thiab glucose-tiv thaiv insulinotropic polypeptide (HIP). Tus incretins yog ib feem ntawm cov txheej txheem kho mob sab hauv lub zog rau kev tswj hwm cov ntshav qabzib homeostasis. Thaum lub siab los yog ua kom cov ntshav qabzib muaj ntau, GLP-1 thiab GUIs nce cov synthesis thiab kev zais ntawm cov tshuaj insulin los ntawm pancreatic beta hlwb. GLP-1 kuj tseem ua rau cov kab tsis sib haum ntawm glucagon los ntawm pancreatic alpha cells, yog li txo qis, yog li ntawd, cov synthesis ntawm cov piam thaj hauv lub siab. Qhov kev ua haujlwm ntawm qhov kev sib txawv no txawv ntawm cov txheej txheem ntawm kev ua ntawm sulfonylurea derivatives, uas txhawb kev tso tawm ntawm insulin txawm tias muaj ntshav qabzib ntau ntau, uas yog fraught nrog txoj kev loj hlob ntawm sulfonyl-hog hypoglycemia tsis yog hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, tab sis kuj nyob rau hauv cov neeg noj qab haus huv. Ua tus xaiv thiab muaj kev cuam tshuam zoo ntawm DPP-4 enzyme, sitagliptin hauv kev kho kom zoo ntau tsis cuam tshuam cov kev ua haujlwm ntawm cov enzymes DPP-8 lossis DPP-9. Sitagliptin sib txawv hauv cov qauv tshuaj thiab cov tshuaj pharmacological los ntawm cov qauv sib piv ntawm GLP-1, insulin, sulfonylurea derivatives lossis meglitinides, biguanides, gamma receptor agonists ua haujlwm los ntawm peroxis proliferator (PPARy), alpha-glycosidase inhibitors thiab amylin analogues.
Metformin yog ib hom tshuaj hypoglycemic uas ua rau muaj cov ntshav qabzib ntau nyob rau hauv cov neeg mob ntshav qab zib hom 2, txo cov ntshav qabzib thiab postprandial ntshav qabzib. Nws cov tshuaj pharmacological ntawm kev ua txawv ntawm cov txheej txheem ntawm kev ua ntawm qhov ncauj tshuaj hypoglycemic ntawm lwm cov chav kawm. Metformin txo cov suab thaj nyob hauv lub siab, txo qis plab hnyuv tawm, thiab nce insulin rhiab heev los ntawm kev coj thiab siv cov piam thaj
Janume, qhia txog kev siv
Yanumet tau qhia ua ib qho kev sib ntxiv rau kev noj haus thiab kev tawm dag zog kom txhim kho glycemic tswj nyob rau hauv cov neeg mob hom II mob ntshav qab zib mellitus uas tsis tau ua tiav kev tswj hwm zoo rau cov keeb kwm yav dhau los ntawm monotherapy nrog metformin lossis sitagliptin, lossis tom qab tsis ua tiav txoj kev kho nrog ob yam tshuaj. Yanumet yog qhia ua ke nrog sulfonylurea derivatives (kev sib xyaw ntawm peb cov tshuaj) ua ib qho kev sib ntxiv rau kev noj haus thiab kev tawm dag zog kom txhim kho glycemic tswj nyob rau hauv cov neeg mob ntshav qab zib hom II uas tsis ua tiav kev tswj hwm txaus tom qab kho nrog ob ntawm peb qho tshuaj no: metformin, sitagliptin lossis derivatives sulfonylureas. Janumet yog qhia ua ke nrog PPAR-? Agonists (piv txwv, thiazolidinediones) ntxiv rau kev noj haus thiab kev tawm dag zog kom txhim kho glycemic tswj nyob rau hauv cov neeg mob ntshav qab zib hom II uas tsis ua tiav kev tswj txaus tom qab kho nrog ob ntawm peb qho tshuaj no: metformin, sitagliptin, lossis PPAR-β agonist. Yanumet tau qhia rau cov neeg mob uas muaj ntshav qab zib hom II mellitus (kev sib xyaw ntawm peb cov tshuaj) ua ib qho kev sib ntxiv rau kev noj haus thiab kev tawm dag zog kom txhim kho glycemic tswj nyob rau hauv kev sib xyaw nrog insulin.
Cov Yuav Tsum Muaj
- Cov tshuaj tiv thaiv tsis haum rau sitagliptin phosphate, metformin hydrochloride lossis lwm yam tshuaj,
- mob hnyav uas tuaj yeem cuam tshuam rau lub raum kev ua haujlwm: lub cev qhuav dej, mob hnyav, ua rau poob siab,
- mob siab lossis mob ntev uas tuaj yeem ua rau cov nqaij hypoxia, xws li mob plawv lossis ua pa tsis ua haujlwm, tsis ntev los no myocardial infarction, poob siab,
- Mob raum tsis txaus lossis mob raum (creatinine ntshiab)
- Lub siab ua haujlwm tsis zoo,
- qaug cawv ua rau qaug cawv, qaug cawv,
- lub sijhawm pub niam mis,
- ntshav qab zib mellitus hom I,
- mob hnyav los yog mob ntev ntawm tus kab mob metabolic acidosis, nrog rau ketoacidosis uas mob ntshav qab zib (nrog lossis tsis nco qab lawm),
- Kev tshawb nrhiav radiological (kev tswj hwm ntawm lub cev iodine uas muaj cov tshuaj tiv thaiv kev cuam tshuam).
Tsuas tshuaj thiab tswj hwm
Kev noj tshuaj ntau dua ntawm cov tshuaj Yanumet yuav tsum tau xaiv ib tus zuj zus, raws li kev kho tam sim no, kev ua haujlwm thiab kev tuaj yeem, tab sis tsis tshaj qhov siab tshaj qhov pom zoo txhua hnub koob tshuaj sitagliptin 100 mg. Cov tshuaj Yanumet feem ntau tau siv 2 zaug hauv ib hnub nrog zaub mov noj, nrog cov tshuaj tiv thaiv kab mob nce ntxiv, txhawm rau txo cov kev mob tshwm sim los ntawm lub plab zom mov (GIT), cov yam ntxwv ntawm metformin. Thawj qhov hno ntawm cov tshuaj Janumet yog nyob ntawm qhov kev kho mob hypoglycemic tam sim no.
Cev xeeb tub thiab lactation
Tsis muaj cov kev tshawb fawb txaus los ntawm cov tshuaj Yanumet lossis nws cov khoom siv hauv cov poj niam cev xeeb tub, yog li ntawd, tsis muaj ntaub ntawv qhia txog kev nyab xeeb ntawm nws siv hauv cov poj niam cev xeeb tub. Cov tshuaj Janumet, zoo li lwm yam tshuaj rau qhov ncauj hypoglycemic, tsis pom zoo rau siv thaum cev xeeb tub. Muaj tsis muaj kev sim tshuaj rau kev sib xyaw ua ke ntawm cov tshuaj Yanumet los ntsuas nws cov nyhuv ntawm kev ua me nyuam. Tsuas yog cov ntaub ntawv muaj los ntawm kev tshawb fawb ntawm sitagliptin thiab metformin yog nthuav tawm.
Sab sij huam
Los ntawm cov mob plab zom mov: thaum pib ntawm txoj kev kho mob - tsis nco qab, zawv plab, xeev siab, ntuav, mob plab, mob plab (poob nrog zaub mov), nws yog xim hlau saj hauv lub qhov ncauj (3%).
Los ntawm cov hlab plawv thiab ntshav (hematopoiesis, hemostasis): hauv cov kis mob cais tawm - megaloblastic anemia (los ntawm malabsorption ntawm vitamin B12 thiab folic acid).
Los ntawm ib sab ntawm cov metabolism: hypoglycemia, nyob rau hauv cov xwm txheej tsawg - lactic acidosis (tsis muaj zog, tsaug zog, hypotension, tiv taus bradyarrhythmia, ua pa tsis meej pem, mob plab, myalgia, hypothermia).
Los ntawm daim tawv nqaij: ua pob, ua pob khaus.
Cov lus qhia tshwj xeeb
Siv rau hauv cov laus Yanumet: txij li txoj hauv kev tseem ceeb ntawm kev tshem tawm sitagliptin thiab metformin yog lub raum, thiab txij li kev ua haujlwm tsis muaj zog ntawm lub raum poob qis nrog lub hnub nyoog, qhov kev ceev faj rau kev muab tshuaj Yanumet nce rau hauv kev faib ua feem rau cov hnub nyoog. Cov neeg laus tau txais kev xaiv koob tshuaj thiab saib xyuas lub raum kev ua haujlwm tas li.
Yeeb tshuaj sib cuam tshuam
Sitagliptin thiab metformin
Kev tswj hwm tib lub sij hawm ntau ntawm cov tshuaj sitagliptin (50 mg 2 zaug ib zaug) thiab metformin (1000 mg 2 zaug hauv ib hnub) tsis tau nrog kev hloov pauv hauv pharmacokinetic cov txwv ntawm sitagliptin lossis metformin hauv cov neeg mob ntshav qab zib hom 2.
Cov kev tshawb fawb ntawm cov nyhuv interdrug rau pharmacokinetic cov tsis sib haum ntawm cov tshuaj Janumet tsis tau ua, txawm li cas los xij, muaj ntau qhov kev tshawb fawb zoo li no tau ua rau txhua qhov ntawm cov tshuaj, sitagliptin thiab metformin.
Sitagliptin
Hauv kev tshawb fawb txog kev cuam tshuam nrog lwm cov tshuaj, sitagliptin tsis muaj kev cuam tshuam loj hauv lub chaw muag tshuaj ntawm cov tshuaj hauv qab no: metformin, rosiglitazone, glibenclamide, simvastatin, warfarin, qhov ncauj tawm tsam. Raws li cov ntaub ntawv no, sitagliptin tsis thaiv cov CYP isoenzymes ntawm cytochrome CYP3A4,2C8 lossis 2C9 system. Hauv cov ntaub ntawv hauv vitro qhia tias sitagliptin kuj tsis tiv thaiv CYP2D6,1A2,2C19 thiab 2B6 isoenzymes thiab tsis ntxias CYP3A4. Raws li cov pej xeem pharmacokinetic tsom xam ntawm cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, kev kho mob concomitant tsis muaj kev cuam tshuam loj hauv kev kho mob ntawm pharmacokinetics ntawm sitagliptin. Txoj kev tshawb nrhiav tau soj ntsuam ntau yam tshuaj uas feem ntau siv los ntawm cov neeg mob uas muaj tus mob ntshav qab zib hom 2, nrog rau: cov tshuaj tiv thaiv hypocholesterolemic (statins, fibrates, ezetimibe), tshuaj antiplatelet (clopidogrel), cov tshuaj tiv thaiv kabmob (ACE inhibitors, angitensin II receptor antagonists, beta-blockers, blockers) Cov kab mob "qeeb" calcium, hydrochlorothiazide, analgesics thiab non-steroidal anti-inflammatory drugs (naproxen, diclofenac, celecoxib), tshuaj tiv thaiv kab mob (bupropion, fluoxetine, sertraline), antihistamines (ceti Rizin), tshuaj tiv thaiv proton twj tso kua mis inhibitors (omeprazole, lansoprazole) thiab tshuaj kho rau kev kho mob erectile kawg (sildenafil).
Kev nce hauv AUC (11%), nrog rau C nruab nrab (18%) digoxin tau sau tseg thaum suav nrog sitagliptin.Qhov nce no tsis yog pom tias tseem ceeb hauv tsev kho mob, txawm li cas los xij, kev saib xyuas ntawm tus neeg mob tau pom zoo thaum noj digoxin. Kev nce ntawm AUC thiab C max ntawm sitagliptin tau sau tseg los ntawm 29% thiab 68%, feem, nrog ib qho ncauj tswj hwm ntawm cov tshuaj YANUVIA ntawm koob tshuaj 100 mg thiab cyclosporin (muaj zog inhibitor ntawm p-glycoprotein) ntawm ib koob ntawm 600 mg. Cov kev hloov pauv no hauv cov qauv pharmacokinetic ntawm sitagliptin tsis yog qhov tseem ceeb hauv kev kho mob.
Metformin
Gliburide - hauv kev kawm txog kev sib cuam tshuam ntawm kev siv ib qho metformin thiab gliburide nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, tsis muaj kev hloov pauv hauv pharmacokinetic thiab pharmacodynamic tsis dhau ntawm metformin tau pom. Cov kev hloov hauv AUC thiab Stax glyburide muaj nuj nqis heev. Cov ntaub ntawv tsis txaus (ib qho tshuaj xwb) thiab cov tsis sib xws ntawm cov ntshav plasma concentration ntawm glyburide nrog cov tshuaj muaj txiaj ntsig pom muaj lus nug txog qhov tseem ceeb hauv kev kho mob ntawm qhov kev cuam tshuam no.
Furosemide - hauv kev kawm txog kev sib cuam tshuam tshuaj ntawm tib zaug ntawm cov tshuaj metformin thiab furosemide hauv cov neeg ua haujlwm zoo noj qab haus huv, kev hloov pauv hauv cov chaw muag tshuaj ntawm ob qho tshuaj. Furosemide nce lub siab ntawm C max metformin hauv plasma thiab ntshav tag nrho los ntawm 22%, AUC tus nqi ntawm metformin nyob rau hauv tag nrho cov ntshav nce los ntawm 15%, tsis tas hloov pauv kev txiav tawm ntawm cov tshuaj. Cov txiaj ntsig ntawm C max thiab AUC ntawm furosemide, nyeg, poob qis los ntawm 31% thiab 12%, feem, thiab ib nrab lub neej txo 32%, tsis muaj qhov hloov pauv tseem ceeb ntawm kev kho kom zoo ntawm furosemide. Tsis muaj xov xwm hais txog kev sib cuam tshuam tshuaj nruab nrab ntawm ob cov tshuaj nrog kev siv sijhawm ntev.
Nifedipine - hauv kev kawm txog kev sib cuam tshuam tshuaj ntawm nifedipine thiab metformin tom qab siv tshuaj ib leeg los ntawm cov neeg ua haujlwm noj qab haus huv, kev nce ntshav hauv C max thiab AUC ntawm metformin los ntawm 20% thiab 9%, ntsig txog qhov nce ntxiv ntawm cov tshuaj metformin ua rau lub raum tau raug tso tawm. T max thiab ib nrab-lub neej ntawm metformin tsis tau hloov pauv. Nws yog raws li kev nce rau hauv nqus ntawm metformin nyob rau hauv muaj nifedipine. Cov nyhuv ntawm metformin rau ntawm pharmacokinetics ntawm nifedipine yog qhov tsawg heev.
Cov tshuaj cationic - cov tshuaj cationic (i.e., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren, trimethoprim lossis vancomycin), zais cia los ntawm tubular secretion, tuaj yeem sib cuam tshuam nrog metformin, kev sib tw rau cov tub ntxhais ua haujlwm ntawm cov leeg. tsheb thauj khoom. Cov kev sib tw zoo sib xws tau pom nrog kev tswj hwm tib lub sijhawm ntawm metformin thiab cimetidine los ntawm cov neeg ua haujlwm noj qab haus huv zoo hauv kev tshawb fawb ib leeg thiab ntau txoj kev tshawb fawb, nrog 60% nce ntxiv ntawm cov concentration ntawm C max metformin hauv plasma thiab tag nrho cov ntshav thiab nce 40% hauv AUC ntawm metformin hauv plasma thiab ntshav tag nrho. Hauv kev tshawb fawb ib zaug xwb, ib nrab-lub neej ntawm metformin tsis hloov pauv. Metformin tsis cuam tshuam dabtsi rau pharmacokinetics ntawm cimetidine. Thiab txawm hais tias kev sib cuam tshuam txog yeeb tshuaj no feem ntau yog qhov tseem ceeb theoretical (tshwj tsis yog cimetidine), ua tib zoo saib xyuas tus neeg mob thiab kev hloov tshuaj ntawm cov tshuaj Janumet thiab / lossis cov tshuaj yeeb tshuaj saum toj no, raug zam los ntawm qhov tsis zoo lub raum tubules, pom zoo nyob rau hauv cov ntaub ntawv ntawm lawv cov kev coj ua ib txhij.
Qee cov tshuaj muaj hyperglycemic muaj peev xwm thiab tej zaum yuav cuam tshuam nrog tsim kev tswj glycemic. Cov no suav nrog thiazide thiab lwm cov tshuaj diuretics, glucocorticosteroids, phenothiazines, cov thyroid npaj, estrogens, qhov ncauj tawm tsam, phenytoin, nicotinic acid, sympathomimetics, qeeb calcium channel blockers thiab isoniazid. Thaum sau cov tshuaj no, tus neeg mob uas tau txais cov tshuaj Janumet, nws raug nquahu kom ua tib zoo saib kev tiv thaiv glycemic.Thaum cov neeg ua haujlwm noj qab haus huv tau noj cov tshuaj metformin thiab propranolol lossis metformin thiab ibuprofen, tsis muaj kev txwv cov tshuaj pharmacokinetic ntawm cov tshuaj no.
Tsuas yog ib qho tsis tseem ceeb ntawm metformin khi rau cov ntshav plasma protein, yog li, kev sib cuam tshuam tshuaj sib xyaw ntawm metformin nrog cov tshuaj uas nquag khi rau cov ntshav plasma (salicylates, sulfonamides, chloramphenicol thiab probenecid) tsis zoo li, tsis zoo li sulfonylureas, uas tseem khi rau ntshav protein.
Noj ntau dhau
Sitagliptin: Hauv cov neeg tuaj yeem noj qab haus huv, cov koob tshuaj ib zaug txog li 800 mg feem ntau tau ua haujlwm zoo. Thaum ua ntawv thov nyob rau hauv kev soj ntsuam tshawb, qhov koob tshuaj ntawm 800 mg qhia me ntsis ua tau ntev ntawm Q - Tc luv, uas tsis pom qhov tseem ceeb hauv chaw kho mob. Tsis muaj kev paub txog kev siv cov tshuaj hauv cov koob tshuaj ntau dua 800 mg. Hauv kev tshawb fawb, tsis muaj qhov tshwm sim tsis zoo cuam tshuam nrog koob tshuaj thaum siv 600 mg / hnub rau 10 hnub thiab 400 mg rau 28 hnub. Sitagliptin yog lub cev tsis zoo: raws li kev tshawb fawb hauv tsev kho mob, tsuas yog 13.5% ntawm cov koob tshuaj tau raug tso tawm thaum lub sijhawm 3-4 teev ntawm cov kab mob hemodialysis. Yog tias xav tau kev kho mob, kev kho mob ntev mus ntev yog kho tau. Tsis muaj pov thawj qhia txog kev ua haujlwm ntawm peritoneal dialysis rau sitagliptin. Metformin: muaj cov neeg mob haus ntau tshaj ntawm metformin, suav nrog kev tswj hwm hauv qhov nyiaj tau siab tshaj 50 g. Kev mob ntshav qab zib tau raug kuaj pom nyob hauv kwv yees li 10% ntawm txhua tus neeg mob tshaj plaws, txawm li cas los xij, qhov kev sib raug zoo nrog kev noj tshuaj ntau dua ntawm metformin tsis tau tsim muaj. Kev txhim kho ntawm cov kab mob lactic acidosis tau tshaj tawm kwv yees li 32% ntawm txhua kis ntawm kev haus ntau tshaj plaws ntawm metformin. Kev kub ntxhov ceev yog qhov tsim nyog (metformin raug lim ntshav ntawm lub nrawm txog li ntawm 170 ml / min nyob rau hauv kev mob ntawm ntshav qab zib zoo) txhawm rau txhawm rau tshem tawm cov tshuaj metformin ntau dhau rau thaum muaj kev xav ntau tshaj. Yog tias dhau ntawm kev siv tshuaj ntau dhau, Janumet yuav tsum pib ua tus qauv kev txhawb nqa: tshem tawm ntawm txoj hnyuv seem uas tseem tshuav cov tshuaj uas tseem tsis tau yoog, saib xyuas cov cim tseem ceeb, suav nrog ECG, hemodialysis, thiab kev teem sijhawm kho kev kho, yog tias tsim nyog.
Cia rau cov neeg mob
Khaws ntawm qhov kub thiab txias tsis tshaj 25 ° C.
Kev Sib Sau thiab daim ntawv ntawm kev tso tawm
Qhov peculiarity ntawm cov tshuaj no yog feem ntau tias nws muaj ob yam tshuaj uas txuam nrog sib txuam nrog ib zaug. Qhov tseem ceeb kho ntawm cov tshuaj no yog metformin hydrochloride. Cov tshuaj "Yanumet" muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj. Ntawd yog, nws yuav tsum tau hais ntawm ncauj. Metformin nyob rau hauv kev sib xyaw ntawm ib qho xws li ntsiav tshuaj yuav suav nrog 500, 850 lossis 1000 mg.
Qhov tseem ceeb thib ob ntawm Yanumet yog sitagliptin. Cov khoom xyaw no, tsis hais txog cov ntsiab lus ntawm metformin hydrochloride, ib txwm muaj nyob hauv qhov nyiaj ntawm 50 mg hauv ib ntsiav tshuaj. Ob qho tshuaj yeeb dej caw ntawm cov tshuaj muaj peev xwm tswj cov ntshav qab zib kom siab.
Ntawm chav kawm, zoo li nrog lwm cov ntsiav tshuaj, cov muaj pes tsawg leeg ntawm "Yanumet" suav nrog cov khoom xyaw pabcuam. Tab sis tsis muaj ib qho ntawm nws muaj cov kev kho kom zoo rau tus neeg mob lub cev.
Hauv kev tsim cov ntsiav tshuaj ntawm cov tshuaj no yog coated, muaj, ntawm chav kawm, sib xyaw ua ke sib xyaw tshuaj lom neeg. Ua tsaug rau daim ntawv tso tawm no, cov ntsiav tshuaj Yanumet tsis muaj kev phom sij ntawm lub plab zom mov ntawm cov neeg mob.
Dab tsi yog metformin hydrochloride?
Qhov txiaj ntsig ntawm cov tshuaj no rau cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus yog, ua ntej txhua yam, uas thaum nws nkag rau hauv lub cev, nws txo:
synthesis ntawm cov piam thaj hauv lub siab,
plab hnyuv tuaj yeem haum.
Qhov sib xyaw ua ke ntawm Yanumet thiab cov yeeb yaj kiab sib xyaw ntawm cov tshuaj no nrog cov sib txuam zoo sib xws muaj peev xwm nce cov neeg mob hlwb kom insulin los ntawm kev ntes thiab siv cov piam thaj.Ntau pheej pheej yig hloov chaw rau cov tshuaj no, zwm rau pab pawg ntawm mono-tshuaj, tau los ntawm kev tsuas yog cov metformin ua cov tshuaj nquag.
Sitagliptin ua hauj lwm li cas?
Qhov tshuaj yeeb yam thib ob ntawm Yanumet nyob rau hauv lub cev ntawm tus neeg mob uas muaj ntshav qab zib hom 2 tiv thaiv qhov enzyme DPP-4, uas ua rau muaj qhov nce ntawm cov tshuaj hormones nquag GLP-1 thiab HIP, uas yog lub luag haujlwm rau kev tswj hwm tus kheej ntawm cov piam thaj. Cov kev ua ntawm DPP-4 thaum noj cov neeg mob "Yanumeta" yog suppressed rau kwv yees li 24 teev. Hauv kev sib piv nrog metformin, sitagliptin tau suav hais tias yog cov tshuaj txhaum cai me ntsis rau tus neeg mob lub cev rau cov kev mob tshwm sim. Kev txiav ntshav siab xav tswj ntshav qab zib cov ntshav hauv cov neeg mob ntshav qab zib kuj tseem ua rau nws lub hauv paus.
Cov tshuaj ntxiv
Ntxiv nrog rau metformin hydrochloride thiab sitagliptin, cov muaj pes tsawg leeg ntawm Yanumet suav nrog cov kev pabcuam xws li:
Lub khauj khaum ntawm cov ntsiav tshuaj no, nrog rau lwm yam, polyvinyl cawv, titanium dioxide, talc, dub thiab liab hlau oxide, macrogol. Yog tias tus neeg mob ntshav qab zib ua xua rau txhua yam ntawm cov tshuaj no, koj yuav tsum tsis kam lees noj Yanumet.
Cov tshuaj tiv thaiv zoo tshaj plaws
Tus nqi ntawm Yanumet ntsiav tshuaj nyob ntawm feem ntau ntawm cov nyiaj ntawm metformin hydrochloride suav nrog lawv cov lus. Cov tshuaj no, muab los ntawm Netherlands (nrog ntim hauv tebchaws Russia), yog, hmoov tsis, kim heev. Piv txwv li, lub pob ntawm cov ntsiav tshuaj "Yanumet" hauv qhov nyiaj ntawm 56 pcs. ntawm kev noj tshuaj ntawm 500 mg yuav them tus nqi rau tus neeg mob, nyob ntawm thaj av, 2500-3000 p. Yog li, ntau tus neeg muaj ntshav qab zib hom 2, yog, txaus siab yuav suav nrog seb cov tshuaj no puas muaj cov tshuaj yeeb zoo dua.
Hmoov tsis zoo, kev npaj muaj nrog cov qauv qub uas muaj ntawm Yanumet tseem tsis tau tsim hauv Russia. Feem ntau hloov chaw txawv teb chaws tsis qis dua nyob rau hauv nqe rau cov cuab yeej no. Cov lus piav qhia hauv analogue tsuas yog siv rau cov tshuaj "Yanumet", muag ntawm tus nqi qis dua, nyob hauv Russia thaum lub sijhawm tam sim no yog "Galvus Met".
Kev hloov zoo tshaj plaws rau cov khoom no nrog cov qub muaj pes tsawg leeg tam sim no suav hais tias yog Velmetia. Cov neeg uas tab tom nrhiav ib qho analogue ntawm Yanumet 1000 + 50 mg, piv txwv li, yuav tsum them sai sai rau cov tshuaj no.
Tsis tas li, qee kis, cov tshuaj no yuav raug hloov los ntawm:
Txog cov qauv ntawm Yanumet no, cov lus qhia rau kev siv yog muab rau yuav luag zoo tib yam li rau cov tshuaj no nws tus kheej. Txawm li cas los xij, cov tshuaj sib xyaw cov tshuaj no txawv me ntsis. Yog li ntawd, kev tswj cov piam thaj nrog lawv txoj kev siv tuaj yeem nqa tau raws li lwm cov dag zog. Nyob rau hauv txhua rooj plaub, nws tsim nyog hloov lub Yanumet rau cov tshuaj no, raws li, tseeb, rau lwm yam tshuaj analogues, ntawm kev pom zoo los ntawm kws kho mob.
Tsis tas li, qee kis, Yanumet tuaj yeem hloov pauv los ntawm kev sib txuas ntawm ob qho kev siv tshuaj tsis tshua zoo - Januvia (Netherlands) thiab Glucophage, uas yog tus qub metformin.
Cov tshuaj "Galvus Met"
Cov tshuaj no zwm rau qeb ntawm "Yanumet" pawg analogues. 1000 txog 50 mg yog ib qho ntawm nws cov tshuaj feem ntau. Ib qho ntawm cov khoom xyaw tseem ceeb hauv nws kuj yog metformin. Tab sis hloov ntawm sitagliptin, vildagliptin muaj nyob hauv nws cov muaj pes tsawg leeg ntawm 50 mg. Ib lub hlis ntawm kev kho cov tshuaj no yuav raug nqi ib tus neeg mob ntshav qab zib li 1600 p. Cov tshuaj no tseem muaj nyob hauv cov ntsiav tshuaj thiab yog npaj rau lub qhov ncauj.
Metformin tseem muaj nyob hauv cov qauv ntawm cov Yanumet Combogliz Prolonga thiab Gentadueto. Hauv qhov no, thawj cov tshuaj ntxiv nrog rau saxagliptin, thiab lub thib ob - linagliptin.
Analog "Velmetia"
Cov tshuaj no yog tsim los ntawm cov tuam txhab tsim khoom hauv tebchaws Russia, Berlin-Chemie. Nws yog tsim feem ntau ntawm cov lag luam ntawm Ltalis thiab Spain. Cov tshuaj tseem ceeb hauv cov tshuaj no, zoo li Yanumet nws tus kheej, yog metformin thiab sitagliptin.Ntxiv mus, cov tshuaj zoo li no tau xa mus rau kev ua lag luam hauv ob qhov tshuaj: 850 + 50 mg thiab 1000 + 50. Hauv Lavxias, Velmetia analogue ntawm Yanumet, hmoov tsis, tsuas tuaj yeem muas tau ntawm kev txiav txim. Tsis tas li, cov tshuaj no tseem kim heev.
Pheej yig hloov chaw
Hauv Lavxias, analogues ntawm Yanumet 1000 + 50 mg, 850 + 50 mg, thiab lwm yam, yog li, muaj ob peb. Tab sis tag nrho cov tshuaj, uas yog qhov tseem ceeb ua ke nrog cov tshuaj no (txij li thaum lawv muaj tib yam los yog muaj pes tsawg leeg), hmoov tsis tseem kim. Txawm li cas los xij, pheej yig analogues ntawm cov tshuaj no, ua rau lub hauv paus ntawm lwm cov khoom siv lossis lwm txoj hauv kev, piv txwv li, kev tsim khoom hauv tsev hauv khw muag tshuaj, tau kawg, kuj tseem muaj. Feem ntau, txiav txim los ntawm kev tshuaj xyuas cov neeg mob, lawv cov ntshav qab zib qis qis qis dua qhov tsis raug nqi, raug tsim los ntawm qhov pom ntawm qhov ua tiav tau tam sim no, Yanumet. Tab sis tseem, xws li cov tshuaj rau ntshav qab zib, ntawm chav kawm, tuaj yeem muaj txiaj ntsig zoo.
Piv txwv li, cov tshuaj hauv qab no tuaj yeem raug ntaus rau cov pab pawg ntawm pheej yig cov tshuaj tiv thaiv ntawm cov tshuaj Yanumet:
Cov tshuaj no feem ntau siv rau cov neeg mob ntshav qab zib los ntawm kws kho mob. Ntau tus neeg mob xav txog tag nrho cov kev sib piv ntawm Yanumet no yuav pab tau zoo heev.
Kev ntsuas rau siv
Cov tshuaj "Yanumet" yog kws kho mob sau los ntawm kws kho mob rau cov neeg mob ntshav qab zib feem ntau. Yog lawm, cov tshuaj no, zoo ib yam li lwm yam zoo sib xws, hauv kev kho mob tsuas yog ib qho ntxiv rau kev noj haus tshwj xeeb tsim rau tus neeg mob thiab kev tswj hwm ntawm kev siv lub cev. Nws ua tau zoo dua yog tias tus kab mob hauv ib tus neeg nrog nws rog.
Feem ntau, cov kws kho mob tau sau ntawv rau cov neeg mob ntshav qab zib hom 2 "Yanumet" nrog rau lwm cov tshuaj. Piv txwv, feem ntau nws ua ke nrog sulfonylurea derivatives, PPAR agonists, thiab nrog insulin.
Cov Yuav Tsum Muaj
Cov tshuaj niaj hnub no tau sau tseg, zoo ib yam li lwm yam, tau kawg, tsis yog txhua tus neeg mob tuaj yeem. Thaum twg koj tsis tuaj yeem siv cov tshuaj "Yanumet" los tswj cov ntshav qab zib raws li cov lus qhia thiab cov tshuaj zoo li 1000 + 50 mg, 500 + 50 mg, 850 + 50 mg ntawm cov tshuaj no? Cov tshuaj no tsis raug sau tseg, tau kawg, rau cov neeg mob uas muaj lub siab ntsws tsis zoo rau lawv ob lub ntsiab lossis ib qho twg ntawm cov khoom siv pabcuam. Nws tseem ntseeg tau tias koj tsis tuaj yeem siv cov tshuaj no hauv cov neeg mob uas mob hnyav uas tuaj yeem cuam tshuam rau lub raum kev ua haujlwm:
nrog mob hnyav.
Cov kws kho mob sau ntawv rau cov neeg mob ntshav qab zib "Yanumet" thiab qee yam ntawm nws cov analogues rau cov mob ntev los yog mob hnyav ua rau cov nqaij mos hypoxia:
ua pa lossis lub plawv tsis ua haujlwm,
tsis ntev los no myocardial infarction.
Nyob rau hauv tsis muaj qee yam yuav tsum tau koj noj cov tshuaj no rau intoxication, piv txwv li, nrog cawv. Tau kawg, qhov no siv rau txhua yam analogues ntawm cov tshuaj Yanumet. Nrog rau kev haus dej cawv, raws li koj paub, nws yog txwv tsis pub noj yuav luag txhua yam tshuaj, tshwj tsis yog sorbents.
Tsis tas li, Yanumet tsis tau teev tseg rau:
tsis hnov mob raum muaj nuj nqi.
Koj tsis tuaj yeem haus cov tshuaj no rau cov neeg mob thaum lub caij tshawb nrhiav radiological yog tias lawv tau txhaj nrog iodine-uas muaj cov neeg sawv cev sib piv. Nws yog txwv tsis pub noj cov tshuaj no 48 teev ua ntej txheej txheem thiab 48 teev tom qab nws.
Nrog rau cov ntshav qab zib mellitus ntawm thawj hom, qhov kev kho no tsis muaj txiaj ntsig zoo rau tus neeg mob lub cev. Yog li no, hauv qhov xwm txheej no, tau kawg, nws kuj tsis yog kws kho rau cov neeg mob. Zoo li ntau yam ntawm nws cov analogues thiab hloov pauv, "Yanumet" tsis muaj cai rau cov neeg mob hnub nyoog qis dua 18 xyoo. Cov me nyuam lub hnub nyoog yog ib qho ntawm cov lus tsis sib haum rau cov tshuaj no.
Kuv tuaj yeem siv thaum cev xeeb tub thiab lactation
Hmoov tsis zoo, txij li lub Yanumet npaj yog tseem tshiab heev, tsis tau muaj kev tshawb fawb ntawm nws qhov tseeb ntawm qhov tshwm sim tsis zoo ntawm tus menyuam hauv plab.Tam sim no tsis muaj cov ntaub ntawv qhia txog nws kev nyab xeeb rau cov poj niam cev xeeb tub thiab lawv cov menyuam yaus hauv plab. Yog li, zoo li yuav luag txhua lwm tus neeg saib xyuas ntshav qab zib, Yanumet yog contraindicated rau kev siv thaum lub sijhawm xeeb tub. Qhov kev hais daws no tseem tsis yog muab tshuaj rau lactating cov poj niam.
Nyob rau hauv qhov xwm txheej twg yuav tsum ua nrog ceev faj
Ob lub ntsiab lus tseem ceeb ntawm cov khoom siv ntawm Yanumet thiab cov yeeb yaj kiab ntawm cov tshuaj no ntawm cov qub muaj pes tsawg leeg dhau los ntawm lub raum. Raws li koj paub, nrog lub hnub nyoog, cov haujlwm ntawm no hloov hauv cov tib neeg tsawg zuj zus. Yog li, cov tshuaj "Yanumet" rau cov neeg laus yuav tsum tau txiav txim nrog ceev faj. Tus kws kho mob yuav tsum xaiv cov tshuaj rau cov neeg mob zoo siab. Tsis tas li, kev kho mob rau cov neeg laus laus uas muaj ntshav qab zib hom 2 yuav tsum tau ua tshwj tsis yog muaj kev saib xyuas ntawm tus kws tshaj lij. Cov raum ua haujlwm hauv cov neeg mob zoo li no yuav tsum tau kuaj xyuas tsis tu ncua.
Cov neeg laus yuav tsum sau “Yanumet” tsuas yog tom qab kuaj ob lub raum thiab paub tseeb tias lub cev no ua haujlwm zoo. Txwv tsis pub, tus neeg mob zoo li no yuav muaj kev phiv loj heev thaum noj cov tshuaj Yanumet. Yog lawm, nrog kev ceev faj, cov tshuaj no yuav tsum tau kho rau cov neeg hluas hluas uas muaj teeb meem lub raum.
Phiv dab tsi tuaj yeem ua rau
Cov tshuaj no tau nqa los ntawm cov neeg mob ntshav qab zib, txiav txim los ntawm kev tshuaj xyuas cov neeg mob thiab kws kho mob, feem ntau nws zoo heev. Cov kev mob tshwm sim hauv lawv txoj kev kho yog tsawg. Lawv feem ntau tshwm sim nrog tib lub cev xws li nrog txoj kev kho mob nrog metformin nrog cov placebo. Tab sis, tau kawg, zoo ib yam li lwm yam tshuaj, Yanumet thiab cov tshuaj analogues ntawm cov tshuaj no nrog cov khoom sib thooj hauv qee kis tuaj yeem muaj kev cuam tshuam tsis zoo rau tus neeg mob lub cev.
Thaum pib kho nrog cov tshuaj no, qee zaum cov neeg mob muaj kev cuam tshuam los ntawm txoj hnyuv plab. Qhov no yuav yog, piv txwv, xeev siab, ntuav, raws plab. Tsis tas li, ntau tus neeg mob nco ntsoov cov tsos ntawm cov xim hlau hauv lub qhov ncauj thaum noj Yanumet. Qee zaum cov tshuaj no tseem ua rau lub plab thiab mob plab. Lub tom kawg feem ntau txo qis thaum noj mov.
Ntawm ib feem ntawm cov hlab plawv system, hauv kev kho cov tshuaj no, cov neeg mob yuav muaj kev tiv thaiv ntshav liab. Qhov no feem ntau yog vim qhov tseeb tias qhov nqus ntawm folic acid thiab vitamin B12 yog qhov tsis zoo hauv lub cev ntawm tus neeg mob noj Yanumet.
Tsis tas li ntawd, hauv kev kho cov tshuaj no hauv cov neeg mob, cov kev mob tshwm sim xws li:
kev qaug zog thiab qaug zog
Qee qhov xwm txheej, cov tshuaj no tuaj yeem ua pob rau ntawm tus neeg mob lub cev.
Yuav noj li cas
Yuav haus cov tshuaj no li cas raws li cov lus qhia? Cov tshuaj Analogues ntawm Yanumet nrog tib yam lossis zoo sib xws li cov tshuaj no nws tus kheej, feem ntau cov neeg mob noj ib zaug lossis ob zaug ib hnub nrog zaub mov. Txhawm rau kom tsis txhob muaj kev phiv, qhov koob tshuaj ntawm cov tshuaj no yuav tsum tau nce rau qhov tsim nyog maj mam. Cov kws kho mob pom zoo kom nqos tag nrho cov ntsiav tshuaj Yanumet. Yuav kom ua tiav cov nyhuv siab, lawv tsis raug tso cai ua kom tawg, tsoo lossis zom.
Muaj qee kis, cov ntsiav tshuaj ntawm cov tshuaj no yuav tsis ua rau lub plab zom mov tag nrho. Yog tias lawv cov seem muaj nyob hauv cov quav, nws yog qhov yuav tsum tau qhia rau tus kws kho mob uas koom nrog txog qhov no. Tom qab qhov no, tus kws kho mob yuav tsum kuaj xyuas qhov ua tau zoo ntawm glycemic tswj siv cov cuab yeej no.
Muab tshuaj dab tsi
Tau kawg, koj yuav tsum noj nruj me ntsis raws li cov lus qhia "Yanumet" thiab cov lus sib piv ntawm 1000 + 50 mg, 500 + 50 mg, 850 + 50 mg ntawm cov tshuaj no, nrog rau lwm tus. Tus nqi ntawm cov tshuaj Yanumet uas tus neeg mob yuav tsum haus yuav tsum, txiav txim siab tsuas yog txiav txim los ntawm tus kws kho mob. Feem ntau, cov tshuaj thawj zaug ntawm cov tshuaj no yog 500 mg ntawm metformin + 50 mg ntawm sitagliptin ob zaug ib hnub.
Feem ntau, "Janumet" yog tshuaj rau cov neeg mob uas tsis tau txais kev pab los ntawm monopreparations uas muaj tsuas yog ib qho ntawm cov tshuaj no. Hauv qhov no, kev siv tshuaj thawj zaug yuav tsum tau ua raws li qee txoj cai. Thaum tsis muaj qhov ua tau zoo tswj cov tshuaj metformin, piv txwv li, thaum xub thawj tus neeg mob yog "kws kho mob" Janumet "ntau npaum li uas nws siv tsis ntau tshaj 100 mg ntawm sitagliptin ib hnub.
Hauv kev tshwm sim uas ua ntej kev kho mob nrog Yanumet tus neeg mob tau kho nrog sitagliptin, nws raug pom zoo kom txhaj koob tshuaj rau 500 mg metformirn + 50 mg sitagliptin 2 zaug hauv ib hnub. Yog lawm, rau cov tshuaj no, raws li lwm qhov, muaj ntau qhov kev tso cai ntau. Nws ntseeg tias cov neeg mob ntshav qab zib hom 2 yuav tsum tsis txhob noj cov tshuaj no ntau dua 2000 mg ntawm metformin thiab 100 mg ntawm sitagliptin.
Noj ntau dhau
Nws yog ib qhov tseeb, tsim nyog yuav tau noj cov tshuaj no zoo ib yam nkaus li tus kws kho mob tau tuaj koom. Overdoses ntawm Yanumet tsis tuaj yeem thev cia siab. Sitagliptin, txawm tias nyob rau hauv ntau txaus, tsis feem ntau ua rau muaj kev phom sij tshwj xeeb rau tib neeg lub cev. Piv txwv, nws tau pom tias koob tshuaj 800 mg ntawm cov tshuaj no tau zoo los ntawm tib neeg. Hmoov tsis zoo, nws tsis paub yuav ua li cas ntau npaum li cas ntawm cov sitagliptin cuam tshuam rau tib neeg lub cev, txij li kev tshawb fawb tsis tau ua.
Nws ntseeg tau tias kev siv ntau tshaj ntawm metformin, hmoov tsis tseem ua tau. Hauv qhov xwm txheej no, tus neeg mob yuav ua rau lub qog ntshav qab zib. Tsis tas li, haus ntau tshaj ntawm cov tshuaj metformin ua rau kev loj hlob ntawm cov kab mob lactic acidosis. Hmoov tsis zoo, qhov no tshwm sim ntau zaus - hauv 32% ntawm tus neeg mob.
Lactic acidosis yog hu ua kev phom sij txaus ntshai heev, uas cov kua qaub-acid tshuav nyiaj yuav cuam tshuam hauv tib neeg lub cev. Hauv cov ntawv hnyav, qhov mob pathological dhau los, ntawm lwm yam, ua kom lub plawv tsis ua haujlwm. Tom qab, lactic acidosis tuaj yeem ua rau vau thiab anurea, thiab tom qab ntawd ua rau hyperlactacidemic coma.
Pab nrog lactic acidosis
Thaum muaj kev cov nyom no, ntsuas los cawm tus neeg mob yuav tsum ua nrawm dua. Pab tus neeg mob lactic acidosis los ntawm kev ua haujlwm ncaj ncees 4% lossis 2.5% sodium bicarbonate tov. Qhov siab tshaj plaws ntawm cov tshuaj no yog suav tias yog 2000 ml ib hnub. Ib qho ntxiv, nrog cov kab mob lactic acidosis, "kho" luv luv "insulin txoj kev kho tuaj yeem siv los kho cov neeg mob, siv cov kev npaj craboxylase, cov tshuaj reopoiliglukin, ntshav ntshav, thiab heparin.
Yuav ua li cas txaus ntshai lactic acidosis tuaj yeem pom hauv qab no hauv daim duab. “Janumet” thiab cov tshuaj ntawm cov tshuaj no nrog cov sib thooj lossis sib txawv yuav tsum tau noj, yog kiag li, tshwj xeeb rau kev noj tshuaj uas tus kws kho mob tau pom zoo.
Cov tshuaj dab tsi tuaj yeem ua rau qhov tsis muaj zog ntawm kev noj "Yanumet"
Qee hom tshuaj rau tib lub sijhawm nrog cov tshuaj no tsis pom zoo. Txhawm rau ua kom cov nyhuv ntawm tus neeg sawv cev no (metformin) tuaj yeem ua, piv txwv:
thiazide thiab lwm yam kev kho mob,
cov thyroid hormones
Ntawm lwm yam, nws ntseeg tias Yanumet nws tus kheej muaj peev xwm hloov qhov tshwm sim ntawm qee cov tshuaj rau tus neeg mob lub cev. Cov no suav nrog, piv txwv:
Nws tsis pom zoo kom siv qhov sib xyaw ntawm "Yanumet" nrog cov tshuaj no. Yog tias qhov kev kho no txawm li cas los xij tsim nyog, nws yuav tsum yog nyob rau hauv kev saib xyuas ntawm tus kws kho mob uas koom nrog.
Xyuas cov neeg mob txog cov tshuaj
Cov neeg mob ntshav qab zib muaj lub tswv yim zoo txog cov tshuaj no. Cov neeg mob suav nrog qhov zoo ntawm cov tshuaj no hauv thawj qhov chaw, tau kawg, qhov ua tau zoo ntawm nws cov kev ua. Cov neeg mob tuaj yeem siv cov tshuaj no, zoo li ntau lwm tus kws kho mob ntshav qab zib tau ntau xyoo. Qhov tsis muaj qhov sib txawv ntawm cov ntshav qab zib kom ntev ntev nrog kev siv kom zoo - vim li no, hauv web, muaj kev tshuaj xyuas zoo heev txog cov tshuaj Yanumet.Cov analogues ntawm cov tshuaj no, tshwj tsis yog qee yam txawv teb chaws, hmoov tsis, feem ntau tsis muab cov lus tawm zoo li ntawd.
Tsis tas li, qhov tsis muaj qhov zoo ntawm cov tshuaj no suav nrog qhov tseeb tias nws tau muaj qhov tsis zoo kiag li lub siab. Hmoov tsis zoo, feem ntau ntawm cov kev siv yav dhau los los tswj cov ntshav qab zib kom muaj qhov sib ntxiv, hmoov tsis, lawv tsis tuaj yeem khav tau. Tsis tas li ntawd, qhov tsis muaj txiaj ntsig zoo dua ntawm Yanumet, raws li cov neeg mob ntau, yog tias nws tsis ua tiav qhov txiav ntawm lub cev.
Qee tus neeg mob nco tau, nrog rau lwm yam, tias kev siv lub sijhawm ntev ntawm cov tshuaj no txawm ua rau poob phaus. Qhov no, ntawm chav kawm, tseem tuaj yeem suav hais tias yog kev ua haujlwm zoo ntawm Yanumet. Hauv Lavxias, cov tshuaj tiv thaiv kab mob ntawm cov tshuaj no nrog tib cov kev nrhiav tau zoo, tau kawg, yuav nyuaj heev.
Muaj kev coj ua tsis muaj qhov luv luv hauv cov tshuaj no, txiav txim los ntawm kev txheeb xyuas cov neeg muaj ntshav qab zib. Tej zaum tsuas yog tsis zoo ntawm cov tshuaj no, raws li cov neeg mob, yog nws tus nqi siab. Hmoov tsis zoo, tsis yog txhua tus neeg xav tau tuaj yeem siv cov tshuaj no, hmoov tsis zoo.
Kev tshuaj xyuas ntawm cov kws khomob txog cov tshuaj
Cov kws kho mob, zoo li cov neeg mob lawv tus kheej, xav txog Yanumet yog ib qho tshuaj zoo heev. Cov kws kho mob feem ntau muab nws rau lawv cov neeg mob ntshav qab zib hom 2. Ntxiv rau qhov kev ua tau zoo, cov kws tshwj xeeb, zoo ib yam li cov neeg mob lawv tus kheej, kuj tseem cuam tshuam nrog qhov tsis zoo ntawm cov tshuaj no uas nws, tsis zoo li ntau lwm yam tshuaj zoo sib xws, tsis tshua muaj rau ntau yam kev mob tshwm sim. Tias yog vim li cas muaj kev txheeb xyuas zoo heev txog Yanumet los ntawm ntau tus kws kho mob hauv lub vev xaib. Kev sib piv thiab hloov tawm rau cov tshuaj no ntawm tus neeg mob lub cev, raws li kws kho mob, feem ntau muaj ntau yam tsis zoo. Hloov mus rau Yanumet los ntawm lwm cov tshuaj rau qhov laj thawj no, cov kws kho mob ntawm lawv cov neeg mob feem ntau.
Vim tias qhov tseeb tias cov tshuaj no tsis muaj txiaj ntsig zoo rau kev txhim kho, piv txwv li, hypoglycemic syndrome, nws, ntawm chav kawm, tseem tau txais kev tshuaj xyuas zoo los ntawm cov kws kho mob. Cov lus piav qhia ntawm "Yanumet" yog qhov pheej yig kom coj hauv qhov no yuav tsum tau ceev faj ntxiv.
Txawm hais tias qhov tseeb tias cov tshuaj yuav luag zoo, cov neeg tshwj xeeb txawm li cas los tsis qhia rau tus kheej tshuaj siv cov twj no. Cov koob tshuaj ntawm no yuav tsum tau xaiv cov kws kho mob tshwj xeeb. Tsuas yog hauv qhov no, cov tshuaj yuav tsis muaj kev phom sij rau tus neeg mob lub cev thiab yuav ua haujlwm ntau li ntau tau.
Khaws cia li cas
Hauv cov khw muag tshuaj "Yanumet" thiab cov yeeb yaj kiab ntawm cov tshuaj no, ob leeg hauv tsev thiab txawv teb chaws, feem ntau muaj muag tshwj rau cov tshuaj. Yog lawm, yuav kom cov tshuaj no ua haujlwm tau zoo yog tias nws yuav tsum tswj hwm qib hauv qab zib hauv cov ntshav, nws, thiab lwm yam, yuav tsum khaws cia kom zoo. Khaws cov tshuaj no, zoo li feem ntau lwm cov tshuaj, yuav tsum nyob hauv qhov chaw tsaus. Nws ntseeg tau tias Yanumet khaws nws cov khoom tsuas yog qhov ntsuas kub tsis nce siab dua +25 ° C. Yog li ntawd, nyob rau lub caij sov sov nyob rau hnub kub heev, cov ntsiav tshuaj zoo li no yuav tsum muab tso rau hauv tub yees.
Yog lawm, koj yuav tsum khaws cov tshuaj no yam li cov menyuam yaus lossis, piv txwv li, cov tsiaj yug tsiaj nkag tsis tau. Lub txee lub neej ntawm cov tshuaj "Yanumet" yog 2 xyoos txij li hnub pib. Tom qab lub sijhawm no, siv cov tshuaj xws li tswj cov ntshav qab zib kom tsis raug tso cai. Tom qab 2 xyoos txij li hnub tso tawm, cov tshuaj yuav tsum tau muab pov tseg.
Yanumet - cov lus qhia rau kev siv, nqe, xyuas thiab analogues
Yanumet yog qhov sib xyaw ua ke qhov ncauj hypoglycemic siv nyob rau hauv kev kho mob ntawm qhov tsis yog-insulin-mob ntshav qab zib mellitus.Kev noj cov tshuaj pab tswj cov ntshav khov nyob rau hauv lub cev, tiv thaiv kev mob ntawm cov kabmob thiab txhim kho lub neej zoo rau cov neeg mob.
Tso cov ntaub ntawv thiab cov nyob ua ke
Cov tshuaj muaj muag nyob rau hauv daim ntawv ntawm oblong ntsiav tshuaj nrog biconvex nto, npog nrog zaj yeeb yaj kiab enteric ntawm lub teeb liab, liab dawb los yog xim liab (nyob ntawm seb tsuas tshuaj). Cov tshuaj ntim hauv pob blister ntawm 14 daim. Los ntawm 1 mus rau 7 lub hlwv tau muab tso rau hauv ntim ntawm daim ntawv tuab.
Cov khoom xyaw nquag ntawm Yanumet yog sitagliptin nyob rau hauv daim ntawv ntawm phosphate monohydrate thiab metformin hydrochloride. sitagliptin hauv kev npaj yog ib txwm zoo ib yam - 50 mg. Qhov loj ntawm cov metformin hydrochloride ntau dua yuav txawv thiab yog 500, 850 lossis 1000 mg hauv 1 ntsiav tshuaj.
Raws li cov khoom siv sib txuam, Yanumet muaj lauryl sulfate thiab sodium stearyl fumarate, povidone thiab MCC. Lub plhaub tshuaj yog tsim los ntawm macrogol 3350, dej cawv polyvinyl, titanium dioxide, dub thiab liab hlau oxide.
Cov tshuaj ntim hauv pob blister ntawm 14 daim.
Cov tshuaj yog cov tshuaj sib xyaw ua ke uas nws cov tshuaj sib xyaw ua ke muaj qhov ua kom zoo (ua kom zoo) cov ntshav qog ntshav qab zib, pab cov neeg mob ntshav qab zib hom II muaj ntshav qabzib.
Sitagliptin, uas yog ib feem ntawm cov tshuaj, yog ib hom tshuaj tiv thaiv heev ntawm dipeptidyl peptidase-4.
Thaum noj, nws nce los ntawm 2-3 zaug cov ntsiab lus ntawm glucagon-zoo li peptide-1 thiab glucose-dependant insulinotropic peptide - cov tshuaj hormones uas txhim kho cov tshuaj insulin thiab nce nws txoj kev zais cia hauv cov hlwb ntawm cov txiav.
Sitagliptin tso cai rau koj kom muaj qog ntshav qab zib ib txwm nyob thawm hnub thiab tiv thaiv kev txhim kho glycemia ua ntej noj tshais thiab tom qab noj mov.
Kev ua ntawm sitagliptin yog txhim kho los ntawm metformin, cov tshuaj hypoglycemic uas cuam tshuam txog biguanides, uas txo cov concentration ntawm cov piam thaj hauv cov ntshav los ntawm kev thuam 1/3 ntawm cov txheej txheem ntawm cov kua nplaum nyob hauv lub siab.
Tsis tas li ntawd, thaum noj cov tshuaj metformin nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, muaj qhov txo qis hauv kev nqus ntawm cov piam thaj hauv cov zom zaub mov, kev nce siab ntawm cov nqaij ua rau insulin thiab ib qho kev nce ntxiv hauv cov txheej txheem ntawm fatty acid oxidation.
Cov Tshuaj Pharmacokinetics
Qhov siab tshaj plaws ntshav plasma concentration ntawm sitagliptin yog pom 1-4 teev tom qab kev tswj hwm qhov ncauj ntawm ib koob, metformin - tom qab 2.5 teev. Lub bioavailability ntawm cov khoom xyaw nquag thaum siv Yanumet ntawm lub plab khoob yog 87% thiab 50-60%, feem.
Kev siv cov sitagliptin tom qab noj mov tsis cuam tshuam rau nws qhov kev nqus los ntawm cov hnyuv. Kev siv txau cov metformin nrog rau cov zaub mov ua rau nws txo nws qhov nqus dej thiab txo cov tshuaj ntsiab lus hauv plasma los ntawm 40%.
Kev tso tawm ntawm sitagliptin feem ntau tshwm sim nrog zis. Ib feem me me ntawm nws (li 13%) tawm lub cev nrog rau cov ntsiab lus ntawm txoj hnyuv. Metformin ua tiav tawm hauv lub raum.
Metformin ua tiav tawm hauv lub raum.
Sab sij hawm ntawm Yanumet
Thaum noj cov tshuaj, tus neeg mob yuav muaj kev tsis txaus siab ua rau muaj teeb meem los ntawm sitagliptin thiab metformin. Yog tias lawv tshwm sim, nws yog ib qho tsim nyog yuav tsum tsis txhob kho ntxiv thiab mus ntsib kws kho mob sai li sai tau.
Thaum muaj kev mob tshwm sim, nws yog ib qho tsim nyog yuav tsum tsis txhob kho ntxiv thiab mus ntsib kws kho mob sai li sai tau.
Lub plab zom mov
Kev phiv tshuaj los ntawm cov hnyuv feem ntau pom thaum pib theem ntawm kev kho. Cov no suav nrog kev mob nyob rau hauv lub plab zom mov, xeev siab, ntuav, ua kom muaj roj ntau ntxiv hauv cov hnyuv, raws plab, cem quav. Kev noj tshuaj nrog zaub mov tuaj yeem txo cov txiaj ntsig tsis zoo hauv lub plab zom mov.
Hauv cov neeg mob uas tau txais kev kho mob nrog Yanumet, kev txhim kho ntawm tus mob paj hlwb (hemorrhagic lossis necrotizing), uas tuaj yeem ua rau tuag taus, tsis suav nrog.
Los ntawm ib sab ntawm cov metabolism
Yog tias cov koob tshuaj tau xaiv tsis yog, tus neeg mob tuaj yeem ntsib tus mob ntshav qab zib tsawg, uas muaj cov ntshav qab zib kom tsawg. Qee zaum, kev noj tshuaj pab tuaj yeem ua rau cov kab mob lactic acidosis, uas ua rau nws tus kheej poob rau hauv kev hnyav thiab lub cev kub, qhov mob ntawm lub plab thiab cov leeg, mob ntsws, tsis muaj zog thiab tsaug zog.
Los ntawm cov hlab plawv system
Cov tshuaj no tau pom zoo zoo los ntawm cov neeg muaj kev txom nyem los ntawm cov kab mob ntawm lub plawv thiab cov hlab ntshav. Qee zaum, lawv yuav muaj kev txo lub plawv dhia, uas tshwm sim los ntawm cov kab mob lactic acidosis.
Cov tshuaj no tau pom zoo zoo los ntawm cov neeg muaj kev txom nyem los ntawm cov kab mob ntawm lub plawv thiab cov hlab ntshav.
Nrog rau qee tus neeg tsis kam ua rau cov tshuaj uas ua rau muaj tshuaj, ib tus neeg tuaj yeem tsim kev fab tshuaj rau ntawm urticaria, khaus thiab ua pob rau ntawm daim tawv nqaij. Thaum kho nrog Yanumet, qhov ntxim nyiam ntawm daim tawv nqaij, cov leeg mos thiab lub cev nqaij mos, uas ua rau lub neej tsis zoo, tsis raug txiav txim.
Siv thaum cev xeeb tub thiab lactation
Cov tshuaj yuav tsum tsis txhob haus cawv thaum coj tus menyuam, vim tias cov ntaub ntawv hais txog nws txoj kev nyab xeeb rau lub sijhawm no tsis muaj nyob. Yog tias tus poj niam tau txais kev kho mob nrog Yanumet cev xeeb tub lossis npaj siab ua qhov no, nws yuav tsum tsum tsis txhob noj nws thiab pib kho tshuaj insulin.
Kev siv cov tshuaj tsis sib xws nrog kev pub niam mis.
Kev siv cov tshuaj tsis sib xws nrog kev pub niam mis.
Teem Tseg ntawm Yanumet rau menyuam yaus
Cov kev tshawb fawb lees paub qhov kev nyab xeeb ntawm cov tshuaj rau cov menyuam yaus thiab cov hluas tsis tau nqa tawm, yog li nws yuav tsum tsis txhob raug rau cov neeg mob hnub nyoog qis dua 18 xyoo.
Txij li thaum cov khoom xyaw nquag ntawm Yanumet yog tawm hauv cov zis, thiab hauv lub hnub nyoog laus, qhov ua haujlwm ntawm lub raum poob qis, cov tshuaj yuav tsum ua tib zoo xyuas rau cov neeg muaj hnub nyoog 60 xyoo.
Kev cuam tshuam nrog lwm yam tshuaj
Kev sib xyaw ntawm cov tshuaj nrog diuretics, glucagon, qhov ncauj txwv tsis pub muaj, phenothiazines, corticosteroids, isoniazid, calcium antagonists, nicotinic acid thiab cov thyroid hormones ua rau lub cev tsis muaj zog ntawm nws txoj haujlwm.
Cov nyhuv hypoglycemic ntawm cov tshuaj yog kho kom zoo dua thaum siv ua ke nrog cov tshuaj tsis haum steroidal, MAO thiab ACE inhibitors, insulin, sulfonylurea, oxytetracycline, clofibrate, acarbose, beta-adrenergic thaiv cov kab mob thiab cyclophosphamide.
Cawv tau zoo
Nws yog txwv tsis pub haus dej cawv thaum kho mob nrog Yanumet.
Cov txheej txheem sib piv ntawm cov tshuaj yog Valmetia. Cov tshuaj no yog tsim hauv cov qauv tshuaj thiab muaj ib qho muaj pes tsawg leeg thiab muab tshuaj zoo ib yam li Yanumet. Tsis tas li, cov tshuaj muaj cov kev xaiv muaj zog dua - Yanumet Ntev, muaj 100 mg ntawm sitagliptin.
Thaum tsis muaj kev kho mob los ntawm Yanumet, tus kws kho mob tuaj yeem sau tshuaj hypoglycemic rau tus neeg mob, uas metformin ua ke nrog lwm cov tshuaj hypoglycemic. Cov tshuaj no suav nrog:
- Avandamet
- Awb M,
- Douglimax
- Galvus
- Wokanamet,
- Glucovans, thiab lwm yam.
Yanumet Ntev qhia
Amaril txo cov tshuaj qab zib
Kev tshuaj xyuas ntawm cov kws kho mob txog Yanumet
Sergey, 47 xyoo, endocrinologist, Vologda
Rau cov neeg mob uas tsis muaj ntshav qab zib kom tsis txhob mob ntshav qab zib, feem ntau kuv tau sau tshuaj noj, vim tias nws cov txiaj ntsig niaj hnub no tau pom tseeb lawm. Nws tswj cov piam thaj kom zoo thiab kev siv tshuaj tsis ua rau muaj kev mob tshwm sim txawm tias muaj kev kho kom ntev.
Anna Anatolyevna, 53 xyoo, tus kws kho mob endocrinologist, Moscow
Kuv pom zoo kev kho mob nrog Janumet rau cov neeg mob uas tsis tuaj yeem kho lawv cov ntshav qab zib nrog Metformin ib leeg.Cov tshuaj sib xyaw ua ke ntawm cov tshuaj pab ua kom tswj cov ntsuas ntshav qab zib zoo dua.
Qee tus neeg mob ntshai noj tshuaj vim tias muaj kev pheej hmoo ntawm lub qog ntshav qab zib, tab sis cov kev tshawb fawb tsis ntev los no tau qhia tias qhov ntxim nyiam ntawm nws tshwm sim yog tib yam ntawm cov neeg uas tau txais tshuaj noj thiab cov placebo.
Thiab qhov no txhais tau tias cov tshuaj tsis muaj qhov cuam tshuam tseem ceeb rau kev txhim kho hypoglycemic syndrome. Qhov loj tshaj plaws yog xaiv txoj kev ntau npaum.
Cov tshuaj yuav tsum tau ua tib zoo hais rau cov neeg laus dua 60 xyoo.
Kev Ntsuam Xyuas Rau Neeg Mob
Lyudmila, 37 xyoo, Kemerovo
Kuv tau raug mob nrog Janomat tau li ib xyoos. Kuv noj qhov tsawg kawg nkaus ntawm 50/500 mg thaum sawv ntxov thiab yav tsaus ntuj. Rau thawj 3 lub hlis ntawm kev kho mob, nws muaj peev xwm ua tsis tau tsuas yog tswj ntshav qab zib, tab sis kuj poob 12 kg ntawm qhov hnyav dua. Kuv muab cov tshuaj sib xyaw nrog kev noj haus thiab ua kom lub cev qoj ib ce. Tam sim no kuv zoo siab ntau dua li ua ntej kev kho mob.
Nikolay, 61 xyoo, Penza
Nws tau haus tshuaj Metformin rau ntshav qab zib, tab sis maj mam nws tsis pab. Tus kws endocrinologist tau kho nrog Yanumet thiab tau hais tias cov tshuaj no yog cov tshuaj muaj zog ntawm qhov kuv coj ua ntej. Kuv tau noj nws 2 lub hlis, tab sis qab zib tseem tau nce. Kuv tsis pom muaj txiaj ntsig zoo los ntawm kev kho mob.
Yanumet 1000 50: tus nqi, tshuaj xyuas cov tshuaj, cov tshuaj ntawm cov ntsiav tshuaj
Cov tshuaj rau hom 2 ntshav qab zib mellitus tuaj yeem suav nrog kev kho mob monotherapy nrog ib qho tshuaj lossis cov tshuaj tsis yooj yim.
Yanumet, raws li tus neeg sawv cev tiv thaiv kab mob, yog cov tshuaj nrog ob qho khoom xyaw, yog li noj ib ntsiav tshuaj tuaj yeem hloov qhov yuav tsum tau siv ntau cov tshuaj.
Txog rau hnub tim, kev sib xyaw tshuaj nyob rau hauv cov khw muag tshuaj hauv Lavxias muaj tus nqi tsim nyog. Tab sis, raws li cov kws kho mob paub, lawv cov hauj lwm zoo tsuas yog cov nqi ntawd.
Tus neeg sawv cev hypoglycemic yog dab tsi?
Cov tshuaj Yanumet muaj nyob hauv pawg ntawm cov tshuaj nrog cov nyhuv hypoglycemic. Yog vim li ntawd, nws tau feem ntau kho rau mob ntshav qab zib mellitus ntawm ib daim ntawv insulin-ywj siab.
Nws cov txiaj ntsig yog txhim kho los ntawm ntau cov khoom xyaw nquag uas yog ib feem ntawm kev noj tshuaj.
Lub teb chaws ntawm keeb kwm ntawm Yanumet yog Tebchaws Meskas, uas tau piav qhia txog kev siv tshuaj ntau dua (txog li peb txhiab rubles, nyob ntawm seb tsuas tshuaj npaum li cas).
Janumet ntsiav tshuaj siv rau hauv rooj plaub hauv qab no:
- kom txo cov ntshav qab zib, tshwj xeeb yog hais tias kev noj zaub mov kom tsawg ua ke nrog kev tawm dag zog lub cev pom qhov tshwm sim tsis zoo,
- yog monotherapy siv tsuas yog ib qho kev ua haujlwm tsis tau coj cov txiaj ntsig xav tau,
- Nws tuaj yeem raug siv los ua cov kev kho mob ua ke nrog sulfrnylurea derivatives, kev kho tshuaj insulin lossis PPAR-gamma cov kev tawm tsam.
Cov tshuaj muaj nyob rau hauv nws cov muaj pes tsawg leeg ib zaug ob lub cev ua haujlwm uas muaj kev tiv thaiv hypoglycemic:
- Sitaglipin yog tus sawv cev ntawm DPP-4 enzyme inhibitor pawg, uas, nrog rau kev nce hauv cov ntshav qab zib, ua rau lub zog sib txuas thiab ua kom cov kua ntshav tawm los ntawm lub hlwb pancreatic beta hlwb. Raws li qhov tshwm sim ntawm cov txheej txheem no, muaj kev txo cov suab thaj ua ke hauv qab zib.
- Metformin hydrochloride yog ib tus neeg sawv cev ntawm pab pawg thib peb loj loj pab pawg, uas pab txhawb kom muaj kev txwv tsis pub cov kab mob gluconeogenesis. Kev siv cov tshuaj raws li nws stimulates glycolysis, uas ua rau kev txhim kho zoo ntxiv ntawm cov piam thaj los ntawm cov cell thiab cov nqaij mos ntawm lub cev. Ntxiv rau, muaj qhov txo qis hauv kev nqus ntawm cov piam thaj los ntawm cov hnyuv. Qhov txiaj ntsig tseem ceeb ntawm metformin yog tias nws tsis ua rau cov piam thaj hauv qib qis dua (qis dua cov txheej txheem) thiab tsis ua rau kev loj hlob ntawm cov ntshav qabzib.
Kev noj tshuaj ntau npaum li cas tuaj yeem sib txawv ntawm tsib puas mus txog ib txhiab milligrams ntawm ib qho ntawm cov khoom nquag - metformin hydrochloride.Vim li ntawd, cov chaw muag tshuaj niaj hnub muaj rau cov neeg mob li cov tshuaj hauv qab no:
Thawj daim duab hauv cov tshuaj sib xyaw ua ke qhia pom qhov nyiaj ntawm cov txiaj ntsig nquag sitaglipin, qhov thib ob qhia tau muaj peev xwm ntawm metformin. Raws li cov tshuaj tiv thaiv tau siv:
- Microcrystalline cellulose.
- Povidone.
- Sodium stearyl fumarate.
- Sodium lauryl sulfate.
- Polyvinyl cawv, titanium dioxide, macrogol, talc, hlau oxide (lub plhaub ntawm cov ntsiav tshuaj npaj muaj lawv).
Ua tsaug rau cov cuab yeej siv tshuaj kho mob Yanumet (Yanomed), nws muaj peev xwm ua tiav qhov kev txwv tsis pub muaj ntau dhau ntawm glucagon, uas, nrog kev nce ntxiv ntawm cov tshuaj insulin, ua rau cov piam thaj hauv ntshav tsis txaus.
Cov lus qhia rau kev siv ntsiav tshuaj
Tsuas yog tus kws kho mob uas tuaj koom nrog soj ntsuam cov kab mob ntawm lub txheej txheem pathological kho txoj kev kho thiab txoj kev noj tshuaj rau cov neeg mob.
Raws li txoj cai, Yanumet npaj yuav tsum noj ob zaug ib hnub thaum noj mov (thaum sawv ntxov thiab yav tsaus ntuj), haus dej kom ntau.
Cov lus qhia rau kev siv yuav pom tias qhov pib kho yog 500 mg metformin hydrochloride thiab 50 mg sitaglipin ib hnub ob zaug (ib ntsiav tshuaj nrog qhov tsawg kawg nkaus tshuaj).
Cov kev kho mob ntxiv yuav raug yoog nrog nrog ob npaug ntawm metformin.
Yog tias yav dhau los tus neeg mob tau kho hom kev kho mob nrog kev siv tshuaj tsuas yog siv cov tshuaj metformin, thiab kev kho mob zoo li ntawd tsis nqa cov txiaj ntsig tsim nyog, kev siv cov tshuaj yuav ua raws li hauv qab no:
- cov koob tshuaj tam sim no ntawm metformin hydrochloride siv ua ntej khoꓼ
- kev noj kom tsawg ntawm sitaglipin yuav tsum yog yam tsawg 100 mgꓼ
- tus naj npawb ntawm cov tshuaj ib hnub yog ob.
Cov pab pawg ntawm cov neeg mob uas yav tas los siv kev kho mob raws li cov tshuaj uas tsuas siv cov sitaglipin yuav tsum tau txais kev kho mob tshiab raws li cov txheej txheem hauv qab no:
- Ib hnub ob zaug, ib yam tshuaj yog npaum li cas nyob rau hauv ib qho nyiaj ntawm 50 mg ntawm sitaglipin thiab 500 mg ntawm metformin hydrochloride.
- Tom qab, nws yog qhov tau nce ntxiv cov khoom noj uas yog ib feem ntawm ib qho Janumet 1000 ntsiav tshuaj.
Yog tias txoj kev kho mob nyuaj nrog sulfonylurea derivatives siv, cov hauv qab no yuav txiav txim cov tshuaj ntau npaum li cas:
- cov koob tshuaj ntawm metformin hydrochloride yog txiav txim siab nyob ntawm qhov ntsuas ntawm kev loj hlob ntawm pathology hauv tus neeg mob
- kev noj kom tsawg ntawm sitaglipin yog 100 mg, muab faib ua ob koob
- tus nqi ntawm cov tshuaj nquag ntawm sulfonylurea derivatives yog txiav txim los ntawm tus kws kho mob mus kawm raws li cov duab hauv chaw soj ntsuam tus neeg mob.
Ib yam ntawm cov ntawv ntawm kev kho mob yuav tsum tsis suav cov kev haus dej haus cawv, txij li cawv yog categorically contraindicated. Kev sib xyaw nrog lwm cov tshuaj yuav tsum pom zoo nrog kws kho mob.
Nyob rau hauv cov ntaub ntawv ntawm overdose, lactic acidosis yuav tsim.
Txhawm rau tshem tawm nws, cov neeg mob tau pw hauv tsev kho mob thiab nqa tawm cov kev kho mob hauv qab no - kev kho mob, kev kho mob ntawm hemodialysis.
Tus mob dab tsi raug txwv tsis pub siv tus neeg sawv cev hypoglycemic?
Ua ntej pib txoj kev kho mob, koj yuav tsum ua tib zoo nyeem tus naj npawb ntawm cov lus qhia sib kis hauv cov lus qhia ntawm cov lus qhia.
Tsis tas li ntawd, nws yog qhov yuav tsum sab laj nrog koj tus kws kho mob txog kev siv cov tshuaj.
Zoo li ntau yam tshuaj, Yanumet tsis tuaj yeem siv hauv qee kis.
Ua ntej tshaj plaws, nws yog txwv tsis pub noj ntsiav tshuaj yog tias muaj cov haujlwm zoo li no:
- Muaj qhov nce ntxiv ntawm cov neeg tsis muaj zog nyob hauv tus neeg mob mus rau ib lossis ntau ib feem ntawm cov tshuaj.
- Cov teeb meem nrog kev ua haujlwm tsis zoo ntawm lub raum, nrog rau qhov pom ntawm cov xwm txheej uas tuaj yeem cuam tshuam nws tsis zoo. Cov no suav nrog lub cev qhuav dej, chav kawm ntawm cov mob loj, thiab lub xeev poob siab.
- Cov xwm txheej uas yuav ua rau nqaij hypoxia.
- Pheej mob tus kab mob siab lossis nws qhov tsis txaus.
- Thaum qaug cawv.
- Mob hnyav lossis mob ntev ntawm tus mob metabolic acidosis.
- Ntshav qab zib ketoacidosis.
- Ib qho tshuaj insulin-ua daim ntawv ntawm cov txheej txheem pathological.
Txawm hais tias niaj hnub no tsis muaj xov xwm hais txog kev tshawb fawb kho mob hais txog qhov tshwm sim ntawm cov tshuaj ntawm cov menyuam hauv plab, nws yog txwv tsis pub rau kev kho mob nrog nws siv thaum menyuam muaj menyuam lossis ntxiv mis.
Nws yuav tsum raug sau tseg tias thaum lub sijhawm tus neeg mob lub caij txias nws tsis muaj kev pheej hmoo ntawm hypoglycemia. Yog tias tus neeg lub neej hloov pauv, kev tawm dag zog lub cev, ua kom lub siab lossis qaug zog, qhov hloov pauv ntawm kev noj zaub mov (txog kev tshaib plab) tshwm sim, cov ntshav qabzib tuaj yeem poob mus rau theem tseem ceeb.
Ua ntej pib txoj kev kho mob, txoj kev kuaj mob uas tsim nyog thiab soj ntsuam yuav tsum tau ua kom tsis txhob muaj kev tsis zoo thiab tshwm sim los ntawm kev noj tshuaj.
Kev mob tshwm sim thiab tshwm sim tsis zoo
Kev noj qab haus huv feem ntau ntawm tus neeg mob thiab cov kev pheej hmoo ntawm kev nthuav qhia los ntawm cov tshuaj tiv thaiv tsis zoo los ntawm cov plab hnyuv siab raum thiab lub nruab nrog ncaj qha nyob ntawm qhov tseeb ntawm kev noj cov tshuaj thiab nws cuam tshuam nrog lwm cov tshuaj.
Cov kev mob tshwm sim feem ntau tshwm sim thaum tus neeg mob txhaum cov lus qhia kho mob hais txog kev tswj hwm tshuaj.
Cov kev xav tsis zoo tuaj yeem tshwm sim vim yog kev ua txhaum txoj cai ntawm kev noj cov tshuaj no ua ke.
Cov kev phiv loj yog:
- kev tshwm sim ntawm ntau yam teeb meem nrog lub plab zom mov, cov no yog, ua ntej txhua yam, cov tsos mob xws li xeev siab thiab ntuav, raws plab, tsam plab thiab mob hauv plab,
- manifestation ntawm dyspeptic mob,
- cov tshuaj ua rau muaj kev tsis nco qab zoo,
- ib qho kev hloov pauv ntawm qhov kev hnov qab tus kheej yog qhov ua tau, uas tau tshwm sim hauv qhov tshwm sim ntawm qhov tsis kaj siab tom qab ntawm cov hlau nyob rau hauv lub qhov ncauj kab noj hniav,
- qhov kev txo qis hauv cov vitamin B, uas yuam koj ntxiv noj tshuaj nrog cov tshuaj ntxiv,
- kev tsis zoo hauv cov xwm txheej dav dav thiab cov tsos ntawm zoo nkaus li ua rau neeg qaug zog tas li,
- txos cov ntshav siab
- lub siab ua ntxhov,
- manifestation ntawm anemia,
- nrog ib qho tseem ceeb noj ntau dhau, nws yuav muaj kev pheej hmoo ntawm hypoglycemia.
Tsis tas li ntawd, teeb meem nrog daim tawv nqaij yuav tshwm sim yog tias muaj kev ua kom tshwm sim ntawm kev fab tshuaj rau kev noj tshuaj.
Kev tshuaj xyuas los ntawm cov neeg siv khoom thiab cov kws kho mob?
Txog cov tshuaj Janumet, kev tshuaj xyuas sib txawv me ntsis ntawm ntau cov neeg mob.
Ib qeb ntawm cov ntshav qab zib yws yws txog qhov tshwm sim ntawm ntau yam kev tsis zoo uas tau tshwm sim vim kev noj tshuaj.
Lwm tus qhia tias muaj kev tiv thaiv zoo ntawm cov tshuaj, uas pom tias muaj qhov siab txaus ntawm nws cov hauj lwm zoo.
Feem ntau, nws tuaj yeem sib cav tias cov tshuaj muaj peev xwm ua tiav nrog cov kev nqis tes ua rau nws - nws txo qis ntawm cov piam thaj hauv cov ntshav thiab txo qhov kev cuam tshuam ntawm insulin tsis kam. Xws li cov khoom zoo yog manifested vim nws ob lub ntsiab.
Cov tshuaj Janumet tus nqi yog siab txaus, uas yog ib qho ntawm qhov tsis zoo ntawm cov khoom lag luam kho mob no. Tus nqi ntawm cov tshuaj no yog vim los ntawm ob lub ntsiab tseem ceeb:
- cov muaj pes tsawg leeg ntawm kev npaj noj
- ntau lawm los ntawm tuam txhab txawv teb chaws.
Cov kws kho mob tshwj xeeb tshaj tawm lub tswv yim zoo txog kev ua haujlwm ntawm cov tshuaj, hais tias kev ua raws li txhua qhov kev pom zoo uas tsis muaj qhov tsis ua tiav ua rau muaj txiaj ntsig zoo. Hauv qhov no, nws yuav tsum tau ua tib zoo tshuaj rau cov neeg muaj kab mob siab thiab mob raum, nrog rau cov laus.
Nws yuav tsum nco ntsoov tias txhua yam tshuaj hypoglycemic yuav tsum tau noj tsuas yog qhia los ntawm tus kws kho mob koom nrog thiab nyob rau hauv nws txoj kev coj nruj.
Kuv yuav siv tau cov tshuaj twg los hloov?
Tus nqi siab ntawm cov tshuaj ua rau koj xav txog kev nrhiav cov tshuaj zoo sib xws uas yuav pheej yig dua.
Nws yuav tsum raug sau tseg tias hnub no Yanumet analogues hauv khw muag tshuaj muaj sawv cev tsuas yog los ntawm cov cuab yeej kho mob Velmetia. Nws yuav tsum raug sau tseg tias tus nqi ntawm xws li analog yog ob peb zaug siab dua li ntawm Yanumet.
Ntxiv rau, cov tshuaj zoo li no feem ntau tsis muaj nyob hauv cov tsev muag tshuaj hauv nroog thiab tuaj yeem xa tawm thaum thov.
Lwm qhov hloov pauv tau muaj cov nyhuv zoo sib xws, tab sis txawv hauv cov khoom tseem ceeb ntawm cov tshuaj. Muaj ntau tus lej tshuaj uas muaj cov txiaj ntsig zoo ib yam thiab ua ke nrog Yanumet hauv ATC code.
Glibomet yog qhov tshuaj hypoglycemic uas muaj cov khoom siv yooj yim xws li metformin hydrochloride thiab glibenclamide. Cov tshuaj kuj tseem muaj cov nyhuv lipid-txo qis.
Douglimax yog yeeb tshuaj uas yog ib feem ntawm pawg neeg muaj suab thaj txo cov tshuaj. Nws muaj ob qhov tshuaj nquag hauv nws cov muaj pes tsawg leeg - metformin hydrochloride thiab glimepiride.
Tripride yog cov tshuaj ua ke sib xyaw tshuaj raws li metformin thiab pioglitazone. Muaj qhov ntsuas mob zoo sib xws rau Yanumet.
Avandamet kuj tseem siv los ua kom cov ntshav qabzib ntau. Cov nyhuv hypoglycemic tiav vim muaj kev sib cuam tshuam ntawm cov tshuaj muaj zog xws li metformin hydrochloride thiab rosiglitazone.
Cov kws tshaj lij hauv kev yees duab hauv tsab xov xwm no yuav qhia txog cov tshuaj muaj suab thaj kom ua haujlwm zoo tshaj plaws.
Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo. Tshawb nrhiav. Nrhiav tsis pom. Nrhiav. Tsis pom. Pom. Nrhiav. Nrhiav tsis pom.
Yanumet ntsiav tshuaj rau ntshav qab zib hom 2
Yanumet ntsiav tshuaj rau kev siv yog hais txog cov tshuaj hypoglycemic uas siv los them rau cov mob ntshav qab zib hom 2. Nws cov hauj lwm zoo tau txhim kho los ntawm cov tsis sib xws ntawm cov khoom. Nws yog leej twg haum rau thiab yuav siv nws li cas?
Nws feem ntau tau sau tseg yog tias kev hloov kho hauv lub neej thiab kev siv tshuaj kho mob metformin yav dhau los lossis kev kho mob tsis tau coj txoj kev xav tau. Qee lub sij hawm nws yog tshuaj rau cov tib neeg uas koom nrog hauv kev ua kis las thiaj li tswj hwm lawv cov glycemic profile. Ntxiv nrog rau kev paub ntxaws nrog cov lus qhia, ua ntej siv txhua kis, kws kho mob sab laj yog qhov yuav tsum tau ua.
Yanumet: muaj pes tsawg leeg thiab nta
Qhov ua cov nquag ua hauv mis yog metformin hydrochloride. Cov tshuaj tau ntim hauv 500 mg, 850 mg lossis 1000 mg hauv 1 ntsiav tshuaj. Sitagliptin pabcuam ntawm cov tshuaj yog qhov tseem ceeb, hauv ib tsiav tshuaj nws yuav yog 50 mg ntawm txhua koob ntawm metformin. Muaj cov zam rau hauv cov mis uas tsis muaj kev txaus siab nyob rau hauv cov nqe lus ntawm cov tshuaj muaj peev xwm.
Elongated convex capsules yog kev tiv thaiv los ntawm fakes nrog cov ntawv sau "575", "515" lossis "577", nyob ntawm qhov ntau npaum. Txhua pob ntawv cardboard muaj ob lossis plaub daim phiaj ntawm 14 daim. Daim ntawv yuav tshuaj yog muab faib tawm.
Lub thawv kuj tseem qhia txog lub txee lub neej ntawm cov tshuaj - 2 xyoo. Cov tshuaj uas tas sij hawm yuav tsum tau muab pov tseg. Qhov yuav tsum muaj rau qhov chaw cia khoom yog tus qauv: qhov chaw qhuav nkag tsis tau rau hauv lub hnub thiab cov menyuam yaus nrog lub ntsuas kub txog li 25 degrees.
Metformin yog chav kawm ntawm biagudins, sitagliptin - dipeptidyl peptidase-4 inhibitors (DPP-4). Kev sib xyaw ntawm ob qho khoom xyaw muaj zog nrog cov yam ntxwv sib txawv ua rau tswj tau zoo ntawm hypoglycemia hauv cov neeg mob ntshav qab zib nrog hom 2 mob.
Synagliptin
Cov khoom siv yog npaj rau kev siv qhov ncauj. Cov txheej txheem ntawm kev ua ntawm sitagliptin yog ua raws li kev ua kom muaj zog ntau zuj zus. Thaum DPP-4 raug txwv, qib ntawm GLP-1 thiab HIP peptides, uas tswj cov ntshav qabzib homeostasis, nce ntxiv.
Yog tias nws qhov kev ua tau zoo dua, incretins ua kom lub zog tsim cov kua dej siv cov β-hlwb. GLP-1 tseem ua rau kev txhim kho cov glucagon los ntawm α-cov roj ntsha hauv lub siab.
Qhov kev txiav txim siab zoo li no tsis zoo ib yam nrog lub hauv paus ntsiab lus ntawm cov tshuaj sulfonylurea (SM) chav kawm tshuaj uas ua kom cov tshuaj insulin ntau ntxiv rau txhua qib ntawm cov piam thaj.
Cov kev ua si zoo li no tuaj yeem ua rau cov ntshav qog ntshav qab zib tsis yog nyob rau hauv cov ntshav qab zib xwb, tab sis kuj yog hauv cov neeg ua haujlwm noj qab haus huv.
DPP-4 enzyme inhibitor nyob rau hauv cov koob tshuaj pom zoo tsis thaiv qhov ua haujlwm ntawm PPP-8 lossis PPP-9 enzymes. Hauv chaw muag tshuaj, sitagliptin tsis zoo ib yam li nws cov tshuaj ntxiv: GLP-1, insulin, SM derivatives, meglitinide, biguanides, α-glycosidase inhibitors, γ-receptor agonists, amylin.
Ua tsaug rau metformin, kev ua kom cov ntshav qab zib ntau hauv cov ntshav qab zib hom 2 nce: lawv qhov kev xav tsawg dua (ob qho tib si postprandial thiab hauv paus), insulin tsis kam.
Qhov kev txiav txim siab ntawm cov tshuaj muaj txiaj ntsig yog txawv ntawm cov ntsiab cai ntawm kev ua haujlwm ntawm kev hloov pauv kho cov ntshav qab zib.
Txwv tsis pub cov khoom tsim cov glucogen los ntawm lub siab, metformin txo qis nws nqus los ntawm cov hnyuv phab ntsa, txo cov tshuaj insulin tsis kam, ua kom muaj kev cuam tshuam peripheral.
Tsis zoo li SM npaj, metformin tsis ua rau mob ntshav qab zib thiab mob ntshav qab zib tsis muaj ntshav qab zib rau cov neeg mob ntshav qab zib uas muaj hom 2, tsis nyob hauv pawg tswj hwm. Thaum kho nrog metformin, insulin ntau lawm tseem nyob rau tib theem, tab sis nws qhov kev yoo mov thiab cov qib txhua hnub nyiam.
Xuas
Lub bioavailability ntawm sitagliptin yog 87%. Kev siv ntawm cov khoom noj muaj roj ntau ntau thiab cov khoom noj muaj lub cev tsis muaj txiaj ntsig tsis muaj kev cuam tshuam rau tus nqi ntawm kev nqus. Qib siab tshaj plaws ntawm cov tshuaj nyob hauv cov hlab ntshav yog tsau 1-4 teev tom qab nqus los ntawm kev mob hauv txoj hnyuv.
Lub bioavailability ntawm metformin ntawm ib plab khoob yog li 60% ntawm koob tshuaj 500 mg. Nrog ib qho hno ntawm koob tshuaj loj (txog 2550 mg), lub hauv paus ntsiab lus ntawm kev sib luag, vim kev nqus qis, tau ua txhaum. Metformin los ua haujlwm tom qab ob thiab ib nrab teev. Nws qib mus txog 60%. Qhov kawg ntawm metformin yog tsau tom qab ib hnub lossis ob hnub. Thaum noj mov, cov ua haujlwm ntawm cov tshuaj txo qis dua.
Kev xa Khoom
Qhov ntim ntawm kev faib tawm ntawm synagliptin nrog kev siv nrog 1 mg ntawm pawg pab pawg tswj hwm ntawm cov koom hauv kev sim yog 198 l. Cov qib ntawm khi rau cov ntshav protein yog sib txawv me - 38%.
Hauv cov kev sim zoo sib xws nrog metformin, pawg tswj hwm tau muab cov tshuaj rau hauv qhov ntau npaum li cas ntawm 850 mg, qhov faib tawm tib lub sij hawm kwv yees 506 litres.
Yog tias peb piv nrog cov tshuaj ntawm cov chav kawm SM, metformin qhov tseeb tsis khi rau cov protein, ib ntus ib feem me me ntawm nws nyob hauv cov ntshav liab.
Yog tias koj noj tshuaj hauv cov txheej txheem ntau npaum li cas, kev pom zoo (1 / 0.1), feem ntau (> 0.001, 0.001,
Yanumet: cov lus qhia rau kev siv, nqe, xyuas, analogues
Cov tshuaj Yanumet yog qhov ua haujlwm zoo hauv kev tiv thaiv cov ntshav qab zib siab. Vim txoj kev txiav txim siab ua, uas ua tiav ua tsaug rau kev sib txuam ntawm cov tshuaj, cov tshuaj yog qhov tseem ceeb hauv kev kho mob rau cov neeg mob uas muaj tus mob ntshav qab zib hom 2.
Kev sib xyaw ntawm metformin thiab sitagliptin ua rau cov tshuaj no ua tau zoo ntawm kev txo qis cov concentration ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob. Hauv qab no yog cov ntaub ntawv uas tso cai rau koj los txiav txim tsis tsuas yog hais txog qhov zoo thiab cov kev cai dav dav rau kev siv cov tshuaj no, tab sis kuj hais txog tus nqi thiab cov kev mob tshwm sim.
Ib qho ntxiv, thaum kawg ntawm tsab xov xwm, koj tuaj yeem nrhiav kev tshuaj xyuas cov neeg mob noj Yanumet.
Noj ntau dhau
Yog tias Yanumet tau siv ntau tshaj li kev noj tshuaj, cov kev hloov hauv qab no hauv tus neeg mob lub cev tuaj yeem sau tseg: qhov nce siab hauv lub plawv tawm tsam kev mob ntshav qab zib (kuaj hauv 15% ntawm kev noj tshuaj tshaj), qhov txo qis hauv cov kua qaub-lub hauv paus, uas tuaj yeem ua rau mob hnyav - lacticosis.
Qhov kev mob tshwm sim no tau tshawb pom nyob hauv kwv yees li 35% ntawm tag nrho cov xwm txheej ntawm kev siv ntau tshaj ntawm Yanumet.
Tab sis raws li cov kws tshaj lij tau hais, nws tsim nyog suav rau hauv qhov tseeb tias hauv kev kho mob ntshav qab zib mellitus, kev kho mob nyuaj yog nqa tawm, uas txhais tau hais tias tus neeg mob tuaj yeem raug tshuaj lom tsis yog nrog ib hom tshuaj tshwj xeeb, tab sis nrog kev sib xyaw ntawm txhua yam tshuaj tiv thaiv. Yog li no, tham txog cov ntaub ntawv pes tsawg rau kev txhaj tshuaj tshaj ntawm Yanumet tsis tsim nyog.
Nyob rau hauv lub xub ntiag ntawm cov tsos mob no, qhia txog kev noj ntau dhau ntawm cov tshuaj, tam sim ntawd siv txoj kev lees paub feem ntau kom tshem tawm cov tshuaj tsis haum tawm hauv lub cev. Cov no suav nrog cov txheej xwm pab txhawb.
Thawj kauj ruam yog los tshem tawm cov seem ntawm cov tshuaj, uas tsis muaj sijhawm rau kev zom hauv cov hnyuv, ntawm lub cev.
Tom qab ntawd, tus kws tshaj lij yuav tsum ua qhov kev suav sau dav dav ntawm cov ntaub ntawv ntawm tus neeg mob (ECG, kev kuaj mob uas tsim nyog, kev soj ntsuam tas li ntawm cov cim tseem ceeb, hemodialysis tau ua yog tias tsim nyog).
Thaum muaj mob hnyav, yuav tau kho tshwj xeeb, suav nrog tus yam ntxwv ntawm ib tug neeg.
Vim tias nws muaj pes tsawg leeg, nrog rau kev ua haujlwm siab, cov tshuaj tseem ua tus coj ntawm nws cov neeg sib tw.
Cov neeg mob uas kuaj pom tus mob ntshav qab zib thib ob feem ntau yog siv Yanumet, yog tib txoj kev los tswj cov ntshav qab zib kom nyob hauv qhov zoo txaus.
Kev txheeb xyuas txog nws feem ntau yog qhov zoo, vim tias cov tshuaj muaj txiaj ntsig zoo, tsuas yog qhov tsis zoo uas cov neeg siv Janumet feem ntau nco ntsoov yog qhov nqi siab ntawm cov tshuaj. Nov yog qee qhov kev txheeb xyuas txog cov tshuaj no:
Julia los ntawm Moscow hauv nws kev tshuaj xyuas ntawm https://med-otzyv.ru/lekarstva/171-ya/91532-yanumet sau tseg tias Yanumet yog ib yam tshuaj muaj nqis heev. Nws tseem tawm tswv yim los hloov nws nrog Galvus thiab Glyukofazh, uas raug nqi ntau zaus tsawg dua.
Ntawm tib lub vev xaib, Vitalina sau tseg tias tshuaj yog qhov nrov tshaj plaws rau kev kho mob ntshav qab zib hom 2. Tsis tas li ntawd, nws tham txog kev ua haujlwm siab ntawm cov tshuaj thiab qhia txog nws cov txiaj ntsig tseem ceeb - tsis muaj qhov xav tau ntawm kev siv tshuaj insulin nyob rau lub sijhawm.
Sergey ntawm lub xaib http://www.eapteka.ru lus pom zoo txog cov tshuaj uas nws tus txheeb ze noj. Nws sau txog qhov ua tau zoo ntawm Yanumet, tab sis kuj qhia txog cov kev mob tshwm sim me me: thaum pib ntawm kev noj tshuaj ua rau mob xeev siab, uas tom qab ntawd dhau.
Smirnova E.A., kws tshuaj ntawm A5 lub khw muag tshuaj ntawm lub vev xaib https://www.piluli.ru/product/yanumet/expert, hais lus zoo ntawm Yanumet, hais txog nws cov txiaj ntsig zoo thiab cov yam ntxwv ntawm cov khoom sib xyaw ua ke. Tab sis nws kuj hais txog ib tug xov tooj ntawm nws cov contraindications thiab cov kev mob tshwm sim, uas hais txog qhov yuav tsum tau sab laj tus kws kho mob ua ntej siv.
Raws li tag nrho cov lus qhia saum toj no, peb tuaj yeem xaus tias Yanumet yog txoj kev kho mob zoo tshaj plaws rau kev mob ntshav qab zib hom 2. Cov txiaj ntsig zoo tshaj plaws uas cov ntsiav tshuaj qhia tau hais lus rau lawv tus kheej, yog li cov neeg mob tsis ntshai ntawm tus nqi siab rau kev ntim khoom.
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Kev ntxhov siab thiab kis kab mob tuaj yeem ua rau ntshav qab zib hauv menyuam yaus
Kev ntxhov siab ntawm menyuam yaus tuaj yeem ua rau mob ntshav qab zib. Peb txhua tus paub tias kev ntxhov siab yog ib feem ntawm lub neej. Lub xeev muaj kev ntxhov siab nws muaj qhov zoo, vim tias nws txhawb peb kom ua. Txawm li cas los xij, kev ntxhov siab siab kawg tuaj yeem tsim teeb meem kev noj qab haus huv. ... -
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