Diabeton mv cov lus qhia rau kev siv, contraindications, phiv, tshuaj xyuas

Kev siv tshuaj yaj yeeb hypoglycemic los ntawm pawg sulfonylurea derivatives ntawm lub cim thib ob.
Npaj: DIABETON® MV
Cov tshuaj nquag ntawm cov tshuaj: gliclazide
ATX Encoding: A10BB09
KFG: Qhov ncauj tshuaj hypoglycemic
Npe sau npe: P No. 011940/01
Hnub sau npe: 12.29.06
Tswv reg reg. doc .: Les Laboratoires SERVIER

Daim ntawv tso tawm Diabeton mv, ntim tshuaj thiab muaj pes tsawg leeg.

Cov hloov kho-tso cov ntsiav tshuaj yog dawb, oblong, nrog tus txaug rau ntawm ob sab: ntawm ib tus yog lub logo ntawm tuam txhab, nyob rau lwm qhov - DIA30.

1 tab
gliclazide
30 mg

Cov muaj mob: calcium calcium phosphate dihydrate, maltodextrin, hypromellose, magnesium stearate, anhydrous colloidal silicon dioxide.

30 pcs - hlwv (1) - pob khoom los ntawm cardboard.
30 pcs - hlwv (2) - pob khoom los ntawm cardboard.

Cov lus piav qhia ntawm cov tshuaj yog ua raws cov lus qhia raug pom zoo rau kev siv.

Pharmacological action Diabeton mv

Qhov tshuaj tiv thaiv ntshav qhov ncauj hypoglycemic los ntawm cov pab pawg ntawm sulfonylurea derivatives ntawm lub cim thib ob, uas txawv cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic nplhaib nrog kev ua kom sib luag.

Diabeton MB txo cov ntshav qabzib ntshav los ntawm kev ua kom muaj kua hauv cov ntshav los ntawm Langerhans islet cells. Tom qab 2 xyoo ntawm kev kho mob, feem ntau cov neeg mob tsis txhim kho kev quav yeeb tshuaj (nce qib ntawm cov tshuaj insulin tom qab thiab kev zais ntsiag to ntawm C-peptides tseem nyob).

Hauv hom 2 mob ntshav qab zib mellitus (non-insulin-dependant), cov tshuaj rov qab thaum ntxov ntawm insulin secretion hauv kev teb rau cov piam thaj thiab txhim kho qib thib ob ntawm insulin secretion. Ib qho tseem ceeb nce ntxiv ntawm insulin secretion tau pom nyob rau hauv teb rau kev tsa ua vim kev noj zaub mov thiab qabzib kev tswj hwm.

Gliclazide muaj qhov tshaj tawm hais tias yog ib tus kabmob ntxiv, i.e. tsub kom qhov rhiab ntawm peripheral cov ntaub so ntswg rau insulin.

Hauv cov leeg nqaij, cov nyhuv ntawm cov insulin rau cov piam thaj, vim yog kev txhim kho ntawm qhov rhiab ntawm peripheral cov ntaub so ntswg rau insulin, yog qhov nce ntau (+ 35%). Cov nyhuv ntawm gliclazide feem ntau yog vim qhov tseeb tias nws txhawb qhov kev ua ntawm insulin ntawm cov leeg glycogen synthetase thiab ua rau qhov kev hloov pauv tom qab GLUT4 txheeb ze rau cov piam thaj.

Kev mob ntshav qab zib MB txo qhov tsim muaj cov piam thaj nyob hauv daim siab, ua ib txwm yoo cov txiaj ntsig cov piam thaj.

Ntxiv rau nws cov nyhuv rau cov metabolism hauv kev ua kom yuag, gliclazide txhim kho microcirculation. Cov tshuaj txo txoj kev pheej hmoo ntawm cov ntshav me me rau cov ntshav thrombosis, cuam tshuam rau 2 lub tswv yim uas yuav koom nrog kev txhim kho cov teeb meem hauv cov ntshav qab zib mellitus: ib feem ntawm kev txwv tsis pub platelet thiab kev sib dhos thiab ib qho kev txo qis hauv kev ua kom muaj platelet ua kom muaj lwm yam (beta-thromboglobulin, thromboxane B2), nrog rau kev rov kho dua ntawm fibrinolytic. vascular endothelial kev ua si thiab nce kev ua si ntawm cov nqaij mos plasminogen activator.

Gliclazide muaj cov khoom ua antioxidant: nws txo cov ntshav lipid peroxides hauv ntshav, nce kev ua haujlwm ntawm cov ntshav liab ntshav superoxide dismutase.

Pharmacokinetics ntawm cov tshuaj.

Xuas thiab faib khoom

Tom qab noj cov tshuaj hauv, gliclazide yog kiag li nqus los ntawm cov hnyuv. Qhov siab ntawm gliclazide hauv plasma nce zuj zus zuj zus, mus txog toj siab 6-12 teev tom qab kev tswj hwm. Kev noj tsis cuam tshuam rau qib kev nqus. Kev hloov pauv ntawm tus kheej yog qhov tsawg. Cov kev sib raug zoo ntawm qhov koob tshuaj thiab ntshav siab ntawm cov tshuaj yog qhov tso sij hawm tso tawm.

Ib koob tshuaj txhua hnub ntawm tus mob ntshav qab zib MB 30 mg muab cov ntshav zoo ntawm glycazide ntev dua 24 teev.

Plasma protein khi yog 95%.

Gliclazide yog metabolized feem ntau hauv lub siab. Qhov ua rau lub cev zom tau tsis muaj tshuaj lom neeg kev ua si.

T1 / 2 yog li 16 teev (12 txog 20 teev). Nws yog tsuas yog tawm los ntawm lub raum hauv daim ntawv ntawm metabolites, tsawg dua 1% - nrog tso zis hauv daim ntawv tsis hloov pauv.

Dosage thiab txoj hauv kev ntawm kev tswj hwm tshuaj.

Cov tshuaj yog npaj rau cov neeg laus (suav nrog rau cov neeg mob 65 xyoo rov saum thiab laus dua). Qhov pom zoo kom pib noj yog 30 mg.

Kev xaiv koob tshuaj yuav tsum ua raws li theem ntawm cov piam thaj hauv cov ntshav tom qab pib kev kho mob. Txhua qhov hloov pauv koob tshuaj tom qab tuaj yeem ua tom qab tsawg kawg 2-lub lim tiam.

Nrog txoj kev kho kom zoo, ib hnub ib ntawm ib qho pab tswj tau ntshav qabzib kom ntau. Qhov koob tshuaj txhua hnub tuaj yeem hloov los ntawm 30 mg (1 tab.) Txog 90-120 mg (3-4 tab.). Qhov siab tshaj plaws niaj hnub noj yog 120 mg.

Cov tshuaj yuav noj qhov ncauj 1 teev / hnub thaum noj tshais.

Yog tias koj plam ib lossis ntau dua ntawm cov tshuaj, koj tsis tuaj yeem siv tshuaj ntau dua hauv lub koob tshuaj ntxiv.

Rau cov neeg mob uas tsis tau txais kev kho mob yav tas los, kev pib tshuaj yog 30 mg. Tom qab ntawd cov koob tshuaj tau xaiv ib tus zuj zus kom txog thaum qhov txiaj ntsig kho tau tiav.

Tus mob ntshav qab zib MV tuaj yeem hloov pauv tus mob ntshav qab zib tau ntawm 1 mus rau 4 ntsiav tshuaj / hnub.

Hloov los ntawm lwm cov tshuaj hypoglycemic rau Diabeton MB tsis tas yuav muaj sijhawm hloov pauv lub sijhawm. Koj yuav tsum xub tsum tsis txhob noj cov tshuaj hypoglycemic thiab tom qab ntawd tsuas yog sau ntawv rau Diabeton MB.

Diabeton MB tuaj yeem siv ua ke nrog biguanides, alpha-glucosidase inhibitors lossis insulin.

Rau cov neeg mob laus, cov koob tshuaj pom zoo zoo ib yam li rau cov neeg mob hnub nyoog qis dua 65 xyoos.

Yog tias tus neeg mob yav dhau los tau txais kev kho mob nrog sulfonylurea derivatives nrog T1 / 2 ntev (piv txwv, chlorpropamide), yog li ua tib zoo saib xyuas (tswj cov qib glycemia) yog tsim nyog rau 1-2 lub lis piam kom tsis txhob muaj kev txhim kho ntawm hypoglycemia raws li qhov muaj txiaj ntsig ntawm qhov seem ntawm cov kev kho mob dhau los.

Hauv cov neeg mob uas mob mentsis mus txog lub raum lub raum tsis ua haujlwm (CC los ntawm 15 txog 80 ml / min), cov tshuaj tau sau rau hauv tib lub sijhawm ib yam li cov neeg mob uas lub raum tsis ua haujlwm.

Sab Cawv Diabeton mv:

Los ntawm cov kab mob endocrine: hypoglycemia yog ua tau.

Los ntawm lub plab zom mov: xeev siab, raws plab, lossis cem quav yog qhov ua tau (tsis tshua pom muaj thaum cov tshuaj tau noj thaum noj mov), tsis tshua muaj - kev ua si ntau ntawm AST, ALT, alkaline phosphatase, thiab qee zaum muaj mob daj ntseg.

Los ntawm cov kab mob hemopoietic: tsis tshua muaj tshwm sim - muaj ntshav liab, mob leukopenia, thrombocytopenia.

Ua xua: tsis tshua muaj - khaus, urticaria, maculopapular pob.

Cov tshuaj rau txoj kev siv tshuaj:

- mob ntshav qab zib mellitus hom 1 (insulin-dependant),

- uas ketoacidosis, mob ntshav qab zib precoma, mob ntshav qab zib coma,

Mob raum lossis siab mob tsis zoo,

- tib lub sijhawm tswj hwm ntawm miconazole,

- lactation (pub niam mis),

- menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo,

- Cov tshuaj tiv thaiv kab mob rau gliclazide los yog ib qho ntawm cov tsis pom kev tshuaj, lwm yam tshuaj sulfonylurea derivatives, sulfonylamides.

Nws tsis pom zoo kom siv cov tshuaj no ua ke nrog phenylbutazone lossis danazole.

Siv thaum cev xeeb tub thiab lactation.

Muaj cov ntaub ntawv soj ntsuam tsis txaus rau kev ntsuam xyuas qhov kev pheej hmoo ntawm kev ua tsis zoo thiab kev cuam tshuam rau fetotoxic vim yog siv cov tshuaj gliclazide thaum cev xeeb tub. Yog li, kev siv Diabeton MV hauv pawg no ntawm cov neeg mob yog contraindicated.

Thaum cev xeeb tub tau tshwm sim thaum noj cov tshuaj, tsis muaj lub laj thawj meej meej rau nws txoj kev txiav. Nyob rau hauv cov xwm txheej zoo li no, xws li muaj kev npaj xeeb tub, cov tshuaj yuav tsum tau txiav thiab kev kho yuav tsum txuas ntxiv nrog kev npaj tshuaj insulin nyob rau hauv kev saib xyuas ntawm txhua lub chaw kuaj ntsuas ntawm carbohydrate metabolism. Yuav tsum saib xyuas cov ntshav ntawm lub ntsej muag ntshav hauv lub hlwb.

Nws tsis paub meej tias gliclazide raug nthuav tawm hauv niam cov kua mis; tsis muaj pov thawj txog qhov kev pheej hmoo ntawm kev mob neonatal hypoglycemia. Hauv qhov no, kev kho mob nrog gliclazide thaum pub mis niam yog contraindicated.

Hauv kev sim tsiaj cov kev tshawb fawb, nws tau pom tias sulfonylurea derivatives nyob rau hauv cov koob tshuaj tau zoo muaj qhov teebmeem teratogenic.

Cov lus qhia tshwj xeeb rau kev siv Diabeton mv.

Thaum sau ntawv rau tus kab mob ntshav qab zib MB, nws yuav tsum tau yug los rau hauv lub siab tias kev mob ntshav qab zib yuav tshwm sim los ntawm kev noj sulfonylurea derivatives, thiab qee kis mob hnyav thiab ntev, yuav tsum tau pw hauv tsev kho mob thiab ntshav qabzib rau ob peb hnub.

Txhawm rau kom zam dhau kev txhim kho hypoglycemia, kev ua tib zoo xaiv cov neeg mob thiab kev xaiv cov koob tshuaj, nrog rau muab tus neeg mob nrog cov ntaub ntawv tiav ntawm cov kev kho mob uas tsim nyog, yog qhov tsim nyog.

Thaum siv cov tshuaj hypoglycemic hauv cov neeg mob laus, cov neeg uas tsis tu ncua tsis tau txais kev noj haus txaus, nrog cov kab mob uas tsis muaj zog txaus, hauv cov neeg mob adrenal lossis pituitary tsis txaus, qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia tau nce.

Cov tsos mob ntawm tus mob ntshav qab zib yog qhov nyuaj kom paub txog cov neeg laus thiab cov neeg mob tau txais kev kho beta-blocker.

Thaum muab tshuaj kho tus mob ntshav qab zib MV rau cov neeg laus, yuav tsum ua tib zoo saib xyuas ntshav qabzib kom ntau. Kev kho yuav tsum tau pib maj mam thiab thaum thawj hnub ntawm kev kho mob nws yog qhov tsim nyog los tswj kev yoo qab zib thiab tom qab noj mov.

Mob ntshav qab zib MB tuaj yeem tsuas yog kho rau cov neeg mob uas tau txais kev noj mov tsis tu ncua, uas yog suav nrog noj tshais thiab muab cov khoom noj txaus rau hauv kev noj haus. Kev mob ntshav qab zib feem ntau pib txhim kho nrog cov zaub mov tsis muaj calorie, tom qab ua haujlwm ntev lossis ua kom ib ce muaj zog, tom qab haus dej haus cawv, lossis thaum noj ntau yam tshuaj hypoglycemic nyob rau tib lub sijhawm.

Thaum cov tsos mob cholestatic tshwm sim, kev kho yuav tsum muaj kev cuam tshuam. Tom qab tsis ua haujlwm ntawm Cov Mob Ntshav Qab Zib MB, cov tsos mob no feem ntau ploj.

Hauv cov neeg mob uas muaj mob hepatic thiab / lossis lub raum tsis ua haujlwm, qhov hloov pauv ntawm chaw muag tshuaj thiab / lossis chaw muag tshuaj muaj zog ntawm gliclazide yog ua tau. Hauv qee qhov, mob hnyav rau daim siab lossis lub raum tsis ua haujlwm tuaj yeem cuam tshuam kev faib cov gliclazide hauv lub cev. Hepatic tsis muaj peev xwm tseem tuaj yeem pab txo qis glucogenesis. Cov teebmeem no ua rau muaj kev pheej hmoo ntawm kev mob hypoglycemic. Kev mob ntshav nce siab uas tsim kho hauv cov neeg mob no tuaj yeem siv sijhawm ntev heev, nyob rau hauv cov xwm txheej zoo li no, yuav tsum tau kho kom sai.

Kev tswj cov ntshav qabzib hauv cov neeg mob uas tau txais tus mob hypoglycemic tuaj yeem ua kom tsis muaj zog ntawm cov mob hauv qab no: ua npaws, raug mob, kis kab mob lossis kev phais mob. Thaum muaj tej qhov xwm txheej zoo li no, nws kuj yuav tsim nyog los txiav kev kho mob nrog Diabeton MV thiab sau tshuaj rau insulin kho.

Qhov ua tau zoo ntawm Diabeton MB (zoo li lwm cov tshuaj ntawm qhov ncauj hypoglycemic) hauv qee cov neeg mob feem ntau txo qis tom qab lub sijhawm ntev. Qhov no tuaj yeem yog vim muaj kev vam meej ntawm cov ntshav qab zib mellitus lossis txo qis hauv kev teb rau cov tshuaj. Qhov tshwm sim no yog paub tias yog kev tiv thaiv tshuaj thib ob, uas yuav tsum tau coj qhov txawv ntawm qhov tseem ceeb thaum cov tshuaj tau sau tseg rau thawj zaug thiab tsis tsim cov nyhuv tsim nyog. Ua ntej txheeb xyuas tus neeg mob nrog kev tsis txaus ntseeg theem nrab ntawm kev siv tshuaj kho mob, nws yog ib qho tsim nyog yuav tsum ntsuam xyuas qhov tsis txaus ntawm kev xaiv koob tshuaj thiab cov neeg mob ua raws li kev noj zaub mov noj.

Ntawm keeb kwm ntawm kev kho nrog Diabeton MB, phenylbutazone thiab danazole tsis pom zoo. Nws yog qhov zoo dua los siv lwm NSAID.

Tawm tsam keeb kwm ntawm kev kho nrog Diabeton MB, nws yog ib qho tsim nyog yuav tsum tso tseg kev siv dej cawv lossis tshuaj noj, uas suav nrog ethanol.

Nws yog qhov yuav tsum tau ceeb toom rau tus neeg mob thiab nws tsev neeg txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib, nws cov tsos mob thiab cov xwm txheej zoo rau nws txoj kev txhim kho. Nws tseem yuav tsum tau piav qhia qhov tseem ceeb thawj thiab theem nrab tshuaj tiv thaiv yog dab tsi. Tus neeg mob yuav tsum tau txais kev ceeb toom txog cov kev pheej hmoo thiab cov txiaj ntsig ntawm txoj kev kho mob uas tau thov, thiab nws tseem yuav tsum tau qhia nws txog lwm hom kev kho mob. Tus neeg mob xav tau qhia meej txog qhov tseem ceeb ntawm kev noj zaub mov kom xwm yeem, xav tau kev tawm dag zog thiab kev soj ntsuam cov ntshav thiab ntshav qabzib.

Soj ntsuam kuaj

Nws yog ib qho tsim nyog yuav tsum tau txiav txim siab tsis tu ncua qib ntawm cov piam thaj thiab glycosylated hemoglobin hauv cov ntshav, cov ntsiab lus qabzib nyob hauv cov zis.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Cov neeg mob yuav tsum paub txog cov tsos mob ntawm tus mob hypoglycemia thiab siv kev ceev faj thaum tsav tsheb lossis ua haujlwm ua haujlwm uas yuav tsum muaj tus lej siab tshaj plaws ntawm lub cev kev xav.

Kev siv tshuaj ntau dhau:

Cov tsos mob: hypoglycemia, nyob rau hauv mob hnyav - nrog los ntawm coma, convulsions thiab lwm yam kev puas siab puas ntsws neurological.

Kev Kho Mob: Cov tsos mob ntawm tus mob ntshav qab zib tsawg yog kho kho los ntawm kev noj carbohydrates, xaiv ib koob thiab / lossis hloov kev noj haus. Kev ua tib zoo tshuaj xyuas tus neeg mob yuav tsum tau ua mus ntxiv kom txog thaum tus kws kho mob paub tseeb tias tus neeg mob tsis muaj kev phom sij. Thaum muaj mob hnyav, yuav tsum tau txais kev kho mob xwm txheej ceev thiab tau pw hauv tsev kho mob sai.

Yog tias hypoglycemic coma raug xav tias yog lossis kuaj mob, tus neeg mob tau nrawm nrawm nrog 50 ml ntawm cov tshuaj tov ntawm dextrose (qabzib) 40% iv. Tom qab ntawd, ntau dua cov kua roj tov ua kua (qabzib) tov ntawm 5% yog muab tso ncaj rau hauv qhov txhawm rau kom tswj tau qhov qib tsim nyog ntawm cov piam thaj hauv cov ntshav. Kev tshuaj xyuas zoo yuav tsum tau ua tsawg kawg nyob rau 48 teev tom ntej. Nyob rau yav tom ntej, nyob ntawm seb tus neeg mob lub cev, lus nug txog qhov yuav tsum tau soj ntsuam ntxiv ntawm tus neeg mob cov haujlwm tseem ceeb yuav tsum txiav txim siab.

Hauv cov neeg mob uas muaj kab mob siab, lub plasma tshem ntawm gliclazide tuaj yeem ncua sijhawm. Kev lim ntshav feem ntau tsis nqa tawm rau cov neeg mob zoo li no vim hais tias kev khi ntawm gliclazide rau cov ntshav muaj protein ntau.

Kev sib cuam tshuam ntawm Diabeton MV nrog rau lwm yam tshuaj.

Cov tshuaj uas txhim kho cov teebmeem ntawm Diabeton MB

Kev siv ntshav qab zib siv ib txhij D MBon nrog miconazole (rau kev siv tshuaj) muaj peev xwm txhim kho txoj kev loj hlob ntawm hypoglycemia mus txog thaum tsis nco qab.

Kev sib xyaw tsis pom zoo

Phenylbutazone (rau kev siv mauj) txhim kho cov nyhuv hypoglycemic ntawm sulfonylurea derivatives, raws li hloov lawv cov txiaj ntsig nrog cov plasma protein thiab / lossis qeeb lawv qhov kev tshem tawm ntawm lub cev.

Nrog rau kev siv cov Diabeton MB ib txhij, tshuaj thiab cov tshuaj ethanol muaj cov tshuaj hypoglycemia ntau ntau, tiv thaiv kev rov ua paum, thiab tuaj yeem pab txhawb kev txhim kho hypoglycemic coma.

Cov kev ceev faj tshwj xeeb

Kev siv cov beta-blockers npog ib txwm ua rau qee cov tsos mob ntawm cov ntshav qog ntshav qab zib, xws li palpitations thiab tachycardia. Yuav luag txhua qhov kev xaiv tsis-beta-blockers ua rau kom qhov ntau thiab tsawg dua ntawm cov ntshav qog ntshav.

Fluconazole tsub kom lub sij hawm ntau ntawm T1 / 2 sulfonylureas thiab muaj kev pheej hmoo nyob rau hauv lub qog ntshav qab zib.

Kev siv ACE cov tshuaj tiv thaiv ib txhij (captopril, enalapril) tuaj yeem ua rau lub zog hypoglycemic ntau ntawm sulfonylurea derivatives (raws li ib qho kev xav, kev tso kua nplaum ua kom zoo tuaj nrog kev txo qis ntawm cov tshuaj insulin). Kev txhaj tshuaj rau lub cev ntshav tsis txaus yog qhov tsawg.

Tshuaj uas qaug zog tus nyhuv ntawm Diabeton MV

Kev sib xyaw tsis pom zoo

Nrog rau kev siv ua ke nrog cov danazol, qhov txo qis hauv kev ua tau ntawm Diabeton MB yog ua tau.

Cov kev ceev faj tshwj xeeb

Kev sib xyaw ua ke ntawm kev siv ntshav qab zib MB nrog chlorpromazine hauv kev txhaj tshuaj ntau dua (ntau dua 100 mg / hnub) tuaj yeem ua rau nce ntshav nce ntxiv vim tias cov ntshav hauv insulin tsawg.

Nrog rau kev siv GCS ib txhij (rau cov kev siv kab ke, sab nraud thiab hauv zos) thiab tetracosactides, cov ntshav qabzib cov ntshav nce ntxiv nrog kev txhim kho ketoacidosis (kev txo qis hauv qabzib nyob hauv qab ntawm GCS).

Nrog rau kev siv ntshav qab zib ib txhij ntawm MB nrog progestogens, kev ntxim nyiam ntshav qab zib ntawm progestogens hauv kev txhaj tshuaj siab yuav tsum tau muab rau hauv.

Thaum siv ua ke, 2-adrenoreceptor stimulants (rau kev siv tshuaj) - ritodrin, salbutamol, terbutaline nce cov ntshav qabzib (kev tshuaj xyuas nws tus kheej ntawm cov ntshav qabzib yuav tsum muaj, yog tias tsim nyog, hloov mus rau tus neeg mob rau insulin tej zaum yuav xav tau).

Yog tias tsim nyog, kev siv ntawm cov kev sib txuas saum toj saud yuav tsum tswj hwm cov ntshav hauv cov ntshav. Nws yuav tsim nyog los ntxiv kho qhov koob tshuaj Diabeton MB ob qho tib si thaum lub sijhawm sib koom ua ke thiab tom qab tsis txiav tawm cov tshuaj ntxiv.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv noj tshuaj - hloov cov ntsiav tshuaj tso tawm.

Muaj pes tsawg leeg ib 1 ntsiav tshuaj:

Cov tshuaj nquag: Gliclazide - 60.0 mg.
Cov muaj mob: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cP. 160.0 mg, magnesium stearate 1.6 mg, silicon dioxide colloidal anhydrous 5.04 mg.

Cov Tshuaj Hauv Tshuaj

Gliclazide yog sulfonylurea derivative, hypoglycemic qhov ncauj tshuaj uas qhov txawv ntawm cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic nplhaib nrog kev ua kom cov kabmob endocyclic.

Glyclazide txo qis ntshav qabzib los ntawm kev ua kom muaj kua zais ntawm cov kua dej los ntawm beta hlwb ntawm islets ntawm Langerhans. Ib qho nce ntxiv ntawm cov qib ntawm cov tshuaj tua kab mob postprandial thiab C-peptide mob tsawv tom qab 2 xyoos dhau los ntawm kev kho.

Ntxiv nrog rau cov nyhuv ntawm cov metabolism hauv cov metabolism, gliclazide muaj cov teebmeem hemovascular.

Hemovascular cov teebmeem

Glyclazide txo txoj kev pheej hmoo ntawm cov ntshav me me kom tsis muaj teeb meem, muaj feem xyuam rau cov txheej txheem uas tuaj yeem ua rau muaj kev txhim kho ntawm kev mob ntshav qab zib mellitus: ib feem ntawm kev ua kom tsis muaj platelet sib xyaw thiab kev ua rau lub ntsej muag thiab txo qis ntawm kev ua kom cov platelet ua haujlwm (beta-thromboglobulin, thromboxane B2), nrog rau kev rov qab ua haujlwm ntawm fibrinolytic vascular nce kev ua si ntawm cov nqaij mos plasminogen activator.

Xuas

Tom qab lub qhov ncauj tswj hwm, gliclazide yog kiag li kev nqus. Qhov kev ua siab ntev ntawm gliclazide hauv cov ntshav plasma nce ntau zuj zus thaum thawj 6 teev, qib hauv toj siab yog tswj hwm los ntawm 6 txog 12 teev.

Cov tib neeg txawv txav yog tsawg. Noj noj tsis cuam tshuam qhov feem los yog ntu ntawm kev nqus ntawm gliclazide.

Kev zom zaub mov

Gliclazide yog metabolized feem ntau hauv lub siab. Tsis muaj cov metabolites hauv lub plasma ntshav.

Glyclazide raug tso tawm feem ntau los ntawm lub raum: kev nthuav tawm yog nqa hauv daim ntawv ntawm cov tshuaj metabolites, tsawg dua 1% yog tawm los ntawm lub raum tsis hloov.Qhov ib nrab ntawm lub neej ntawm gliclazide yog nruab nrab ntawm 12 txog 20 teev.

Kev ntsuas rau siv

Cov tshuaj Diabeton MV 60 mg tau sau tseg rau cov neeg mob hnub nyoog tshaj 18 xyoo rau kev kho mob ntawm cov mob hauv qab no:

Hom 2 mob ntshav qab zib mellitus nrog cov tsis muaj txiaj ntsig ntawm kev kho zaub mov noj, ua kom lub cev thiab yuag poob.
Kev tiv thaiv ntawm cov teeb meem mob ntshav qab zib mellitus: txo kev pheej hmoo ntawm microvascular (nephropathy, retinopathy) thiab macrovascular muaj teeb meem (myocardial infarction, mob stroke) hauv cov neeg mob hom 2 mob ntshav qab zib mellitus los ntawm kev tswj hwm zoo glycemic.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj no tsuas yog kho rau cov laus!

Qhov koob pom zoo yuav tsum noj ntawm qhov ncauj, 1 lub sijhawm kom zoo dua thaum noj tshais. Cov koob tshuaj txhua hnub yuav yog 30 -120 mg (1/2 -2 ntsiav tshuaj) hauv ib koob. Nws raug nquahu kom nqos ib qho ntsiav tshuaj lossis ib nrab ntawm lub ntsiav tshuaj tag nrho yam tsis ntxo lossis tsoo.

Yog tias koj plam ib lossis ntau dua ntawm cov tshuaj, koj tsis tuaj yeem siv ntau dua koob tshuaj ntxiv, koob tshuaj uas ploj lawm yuav tsum noj nyob rau hnub tom ntej.

Ib yam li lwm cov tshuaj ntshav hypoglycemic, cov koob tshuaj hauv txhua kis yuav tsum raug xaiv nyob ntawm kev saib xyuas cov ntshav qabzib thiab HbAlc.

Thawj zaug muab tshuaj

Thawj qhov pom zoo kom muab koob (suav nrog rau cov neeg mob laus 30 mg ib hnub (1/2 ntsiav tshuaj).

Thaum muaj kev tswjhwm txaus, cov tshuaj hauv qhov tshuaj no tuaj yeem siv rau kev kho kho. Nrog kev tswj tsis tau glycemic txaus, koob tshuaj txhua hnub tuaj yeem raug nce ntxiv mus rau 60, 90 lossis 120 mg.

Qhov koob tshuaj nce siab yog ua tau tsis tau ntxov dua tom qab 1 lub hlis ntawm kev siv tshuaj kho nyob rau ntawm lub koob tshuaj uas tau qhia dhau los. Qhov tshwj tsis yog cov neeg mob uas cov ntshav qabzib concentration tsis tau txo tom qab 2 lub lis piam ntawm kev kho. Nyob rau hauv cov xwm txheej zoo li no, cov koob tshuaj yuav raug nce 2 lub lis piam tom qab pib ua haujlwm.

Qhov siab tshaj plaws uas pom zoo hauv kev siv tshuaj txhua hnub yog 120 mg.

1 ntsiav tshuaj ntawm cov tshuaj Diabeton® MV ntsiav tshuaj nrog kev hloov pauv ntawm 60 mg yog sib npaug rau 2 ntsiav tshuaj ntawm Diabeton® MV ntsiav tshuaj nrog kev hloov pauv ntawm 30 mg Lub xub ntiag ntawm qhov kev tshaj tawm ntawm 60 mg ntsiav tshuaj tso cai rau koj faib cov ntsiav tshuaj thiab noj ib koob tshuaj 30 mg (1/2 ntsiav tshuaj 60 mg), thiab, yog tias tsim nyog, 90 mg (1 thiab 1/2 ntsiav tshuaj 60 mg).

Hloov los ntawm lwm tus neeg sawv cev hypoglycemic mus rau Diabeton MV 60 mg

Diabeton®: MV ntsiav tshuaj nrog kev hloov pauv ntawm 60 mg tuaj yeem siv hloov lwm lub tshuaj hypoglycemic rau kev tswj hwm qhov ncauj. Thaum hloov mus rau cov neeg mob tau txais lwm yam tshuaj ntshav qab zib rau lub qhov ncauj tswj hwm rau Diabeton® MV, lawv cov koob tshuaj thiab ib nrab ntawm lub neej yuav tsum raug coj los txiav txim. Raws li txoj cai, lub sijhawm hloov pauv tsis tas yuav tsum muaj. Qhov muab tshuaj thawj zaug yuav tsum yog 30 mg thiab tom qab ntawv ua raws li lub siab ntawm cov ntshav qabzib. Thaum Diabeton® MV hloov nrog sulfonylurea derivatives nrog ncua ntev ib nrab ntawm lub neej kom tsis txhob mob ntshav qab zib vim tshwm sim los ntawm cov nyhuv ntxiv ntawm ob tus kab mob hypoglycemic, koj tuaj yeem nres noj lawv rau ob peb hnub.

Thawj koob tshuaj ntawm cov tshuaj Diabeton® MV tseem yog 30 mg (1/2 ntsiav tshuaj 60 mg) thiab, yog tias tsim nyog, tuaj yeem nce ntxiv yav tom ntej, raws li tau piav qhia saum toj no.

Cov neeg mob Yuav Muaj Kev Phom Sij Hypoglycemia

Hauv cov neeg mob uas muaj kev pheej hmoo txhim kho hypoglycemia (noj tsis txaus los yog tsis noj zaub mov noj, mob hnyav los yog ua rau cov mob endocrine: pituitary adrenal tsis txaus, hypothyroidism, tshem tawm cov glucocorticosteroids (GCS) tom qab siv ntev thiab / lossis tswj hwm hauv kev txhaj tshuaj ntau dua, cov kab mob hnyav ntawm cov hlab plawv. tshuab - mob ntshav siab rau cov ntshav plawv, mob ntshav siab ntawm cov hlab ntsha carotid, cov mob atherosclerosis zoo heev, nws raug nquahu kom siv cov koob tshuaj tsawg kawg (30 mg) ntawm cov tshuaj Diabeton® MV.

Tiv thaiv tus mob ntshav qab zib muaj teeb meem

Yuav kom ua tiav kev tswj hwm glycemic, koj tuaj yeem maj mam nce cov koob tshuaj Diabeton® MV rau 120 mg / hnub, ntxiv rau kev noj haus thiab kev tawm dag zog, kom ua tiav cov hom phiaj ntawm HbAlc. Nco ntsoov cov kev pheej hmoo ntawm kev txhim kho hypoglycemia. Tsis tas li ntawd, lwm cov tshuaj hypoglycemic, piv txwv li, metformin, ib qho alpha-glucosidase inhibitor, hyazolidinedione derivative lossis insulin, tuaj yeem raug ntxiv rau kev kho mob.

Kev siv cov tshuaj thaum cev xeeb tub thiab lactation

Tsis muaj ntaub ntawv qhia txog qhov siv tau Diabeton MV ntsiav tshuaj thaum lub sijhawm xeeb tub los ntawm poj niam. Dua li ntawm qhov tseeb tias cov kev tshawb fawb tsiaj tsis tau paub tseeb teratogenic thiab embryotoxic cov teebmeem ntawm tus menyuam hauv plab, cov tshuaj no yog contraindicated rau kev kho mob ntawm poj niam cev xeeb tub. Yog tias kuaj ntshav qab zib hauv poj niam thaum cev xeeb tub, tus neeg mob tau xaiv lwm txoj hauv kev ntxiv uas yuav tsis muaj kev phom sij rau tus me nyuam hauv plab. Hauv qhov xwm txheej no, kws kho mob tshuaj xyuas tas li qhov mob ntawm tus poj niam.

Yog tias tus poj niam tau raug kho nrog Tus Mob Ntshav Qab Zib MV, thiab cev xeeb tub twb pib lawm, kev kho mob yuav tsum nres tam sim ntawd thiab sab laj nrog kws kho mob, nco ntsoov qhia txog kev noj tshuaj.

Kev siv cov tshuaj hypoglycemic no thaum lub sijhawm pub mis niam yog txwv tsis pub, txij li cov tshuaj ua haujlwm ntawm cov tshuaj tuaj yeem nkag rau hauv mis, thiab tom qab ntawd mus rau hauv lub cev ntawm tus menyuam. Yog tias tsim nyog, yuav tsum tsis siv tshuaj kho.

Kev ntshav siab

Zoo li lwm yam tshuaj ntawm sulfonylurea pab pawg, cov tshuaj Diabeton MV tuaj yeem ua rau mob ntshav qab zib nyob rau hauv rooj plaub ntawm kev noj cov zaub mov tsis zoo thiab tshwj xeeb tshaj yog tias cov zaub mov tsis zoo. Cov tsos mob tshwm sim ntawm tus mob ntshav qab zib: mob taub hau, tshaib plab, xeev siab, ntuav, ntau zog, pw tsaug zog, chim siab, ntxhov siab, tsis tshua mloog siab, ncua kev tiv thaiv, kev nyuaj siab, tsis meej pem, tsis pom kev thiab hais tsis tau lus, tsis meej pem, tshee, paresis, tswj tus kheej , zoo nkaus li tsis paub pab, tsis pom kev, hnov qab, kiv taub hau, tsis muaj zog, nriaj, ua kom zoo nkauj, ua kom zoo nkauj, ua pa nyuaj, tsaug zog, ploj mus ntawm qhov tsis nco qab nrog txoj kev loj hlob ntawm coma, mus txog rau qhov tuag.

Cov tshuaj tiv thaiv Andrenergic tseem tuaj yeem sau tseg: nce hws, "tawv nqaij" tawv nqaij, ntxhov siab, tachycardia, nce ntshav siab, palpitations, arrhythmia, thiab angina pectoris.

Raws li txoj cai, cov tsos mob hypoglycemia tau nres los ntawm kev noj cov khoom noj carbohydrates (qab zib).

Noj cov khoom qab zib yog qhov ua tsis tau txiaj ntsig. Tawm tsam keeb kwm ntawm lwm cov sulfonylurea derivatives, rov qab kho cov ntshav qog ntshav tau sau tseg tom qab nws tau txais txiaj ntsig zoo.

Thaum mob ntshav qab zib tsawg los yog lub caij ntev, kev kho mob xwm txheej ceev tau qhia, tejzaum nws yuav tsum tau pw hauv tsev kho mob, txawm hais tias muaj qhov cuam tshuam los ntawm kev noj cov zaubmov nyiaj.

Lwm yam phiv

Los ntawm lub plab zom mov: mob plab, xeev siab, ntuav, raws plab, cem quav. Kev noj cov tshuaj thaum noj tshais zam cov tsos mob no lossis txo qis.
Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos ua pob: ua pob. khaus urticaria, Quincke's edema, erythema, maculopapullous tawm pob, cov leeg mob tshwm sim (xws li Stevens-Jones syndrome thiab mob lom epidermal necrolysis).
Hematopoietic plab hnyuv siab raum thiab cov lymphatic system: hematological ntshawv siab (anemia, leukopenia, thrombocytopenia, granulocytopenia) muaj tsawg.
Ntawm ib feem ntawm daim siab thiab kab mob vais plab: nce kev ua haujlwm ntawm "daim siab" enzymes (aspartate aminotransferase (ACT), alanine aminotransferase (ALT), alkaline phosphatase), kab mob siab (raug mob cais tawm). Yog tias muaj tus mob daj ntseg cholestatic tshwm sim, kev kho yuav tsum tsis ua mus ntxiv.
Los ntawm ob sab ntawm cov khoom hauv nruab nrog ntawm lub zeem muag: thaj tsam cuam tshuam txog lub ntsej muag yuav tshwm sim vim yog qhov hloov pauv ntawm cov concentration ntawm cov ntshav qab zib, tshwj xeeb tshaj yog thaum pib kho.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj Diabeton MV 60 mg yuav tsum tsis txhob noj ib txhij nrog miconazole, vim tias qhov kev cuam tshuam no ua rau muaj kev nce siab hauv qhov kev tiv thaiv hypoglycemic, uas tuaj yeem ua rau kev txhim kho hypoglycemic coma.

Cov tshuaj no tuaj yeem txo cov kev kho mob hauv kev tiv thaiv qhov ncauj, yog li, cov neeg mob siv txoj kev tiv thaiv no yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev xeeb tub uas tsis xav tau.

Cov tshuaj tsis pom zoo kom ua ke nrog cov tshuaj uas suav nrog ethanol, vim tias qhov no tuaj yeem ua rau qhov nce hauv hypoglycemic effect thiab kev loj hlob ntawm lub siab mob siab.

Cov Cai Siv Tshuaj So

Cov tshuaj hauv qab no yog cov tshuaj tawm ntawm cov tshuaj Diabeton MV:

Glidiab ntsiav tshuaj
Glidiab MV,
Diabefarm MV,
Gliclazide MV.

Ua ntej hloov cov tshuaj kho mob nrog kev sib piv, tus neeg mob yuav tsum nco ntsoov sab laj nrog tus kws kho endocrinologist.

Tus nqi nruab nrab ntawm cov tshuaj Diabeton MV 60 mg hauv Moscow cov chaw muag tshuaj yog 150-180 rubles rau ib pob (30 ntsiav tshuaj).

Daim ntawv noj tshuaj:

Muaj pes tsawg leeg:
Muaj ib ntsiav tshuaj:
Yam tshuaj muaj sia: gliclazide - 60.0 mg.
Cov muaj tswv yim: lactose monohydrate 71.36 mg, maltodextrin 22.0 mg, hypromellose 100 cp 160.0 mg, magnesium stearate 1.6 mg, anhydrous colloidal silicon dioxide 5.04 mg.

Kev piav qhia
Dawb, biconvex, oval ntsiav tshuaj nrog kev thais thais thiab kos "DIA" "60" ntawm ob sab.

Pab pawg kws tshuaj:

ATX Code: A10BB09

PHARMACOLOGICAL COV CAI

Cov Tshuaj Hauv Tshuaj
Glyclazide yog sulfonylurea derivative, hypoglycemic qhov ncauj tshuaj uas txawv ntawm cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic ntiv nplhaib nrog kev ua kom cov kabmob endocyclic.
Gliclazide txo qis kev xav ntawm cov ntshav qabzib, txhawb kev tso pa tawm ntawm insulin los ntawm β-hlwb ntawm cov islets ntawm Langerhans. Kev nce siab ntawm cov tshuaj tom qab tawm insulin thiab C-peptide mob tsawv tom qab 2 xyoos dhau los ntawm kev kho.
Ntxiv nrog rau cov nyhuv ntawm cov metabolism hauv cov metabolism, gliclazide muaj cov teebmeem hemovascular.

Ntxim rau insulin secretion
Hauv hom 2 mob ntshav qab zib mellitus, cov tshuaj rov qab ua rau lub sijhawm thaum kawg ntawm cov kua dej hauv cov kua dej hauv cov lus teb rau cov piam thaj thiab ua rau qib thib ob ntawm insulin zais cia. Ib qho tseem ceeb nce ntxiv ntawm insulin secretion tau pom nyob rau hauv teb rau kev tsa ua vim kev noj zaub mov ntau dua lossis cov tshuaj tswj cov piam thaj.

Hemovascular cov teebmeem
Glyclazide txo txoj kev pheej hmoo ntawm cov ntshav me me kom tsis muaj ntshav txaus los ntawm kev cuam tshuam cov txheej txheem uas tuaj yeem ua rau muaj kev txhim kho ntawm cov teeb meem hauv cov ntshav qab zib mellitus: ib feem ntawm kev thaiv cov ntshav platelet thiab kev ua rau txhawm rau thiab txo qis hauv kev ua kom muaj platelet ua kom muaj lwm yam (beta-thromboglobulin, thromboxane B₂), ntxiv rau kev rov ua haujlwm fibrinolytic ntawm cov leeg ntshav endothelium thiab nce kev ua haujlwm ntawm cov nqaij mos plasminogen activator.
Kev siv tshuaj tiv thaiv zoo glycemic raws li kev siv Diabeton ® MV (HbA1c Lub tswv yim ntawm kev siv tshuaj tiv thaiv glycemic muaj xws li kev teem sijhawm siv tshuaj Diabeton ® MV thiab nce nws qhov kev siv tshuaj tiv thaiv cov keeb kwm yav dhau los (lossis hloov) kev kho mob ua ntej ntxiv lwm qhov tshuaj tiv thaiv hypoglycemic (xws li metformin, ib qho alpha-glucosidase inhibitor) thiazolidinedione derivative lossis insulin.) Qhov nruab nrab txhua hnub ntawm cov tshuaj Diabeton ® MV hauv cov neeg mob hauv pawg tswj hwm hnyav yog 103 mg, qhov siab tshaj plaws txhua hnub qhov koob tshuaj yog 120 mg.
Tawm tsam cov keeb kwm yav dhau los ntawm kev siv tshuaj yeeb tshuaj Diabeton ® MV nyob rau hauv kev tswj hwm glycemic tswj (kev soj qab taug qab lub sijhawm 4.8 xyoo, nruab nrab HbA1c qib 6.5%) piv nrog pawg tswj hwm (nruab nrab HbA1c qib 7.3%), qhov txo qis 10% yog pom cov kev pheej hmoo sib piv ntawm cov kev sib xyaw ua ke ntawm macro- thiab cov teeb meem microvascular
Qhov kom zoo dua tau ua tiav los ntawm kev txo tus mob sib piv: loj microvascular teeb meem los ntawm 14%, qhov pib thiab kev loj hlob ntawm nephropathy los ntawm 21%, qhov tshwm sim ntawm microalbuminuria los ntawm 9%, macroalbuminuria los ntawm 30% thiab kev txhim kho lub raum mob ntxiv los ntawm 11%.
Cov txiaj ntsig ntawm kev tswj hwm zoo glycemic thaum noj Diabeton ® MV tsis cia siab rau cov txiaj ntsig tau ua tiav nrog antihypertensive kho.

Cov Tshuaj Pharmacokinetics

Xuas
Tom qab kev tswj hwm ntawm qhov ncauj, gliclazide yog kiag li kev nqus. Qhov kev ua siab ntev ntawm gliclazide hauv cov ntshav plasma nce ntau zuj zus thaum thawj 6 teev, qib hauv toj siab yog khaws cia los ntawm 6 txog 12 teev. Cov kev hloov pauv ntawm tus kheej muaj tsawg.
Noj noj tsis cuam tshuam qhov feem thiab qib ntawm kev nqus ntawm gliclazide.

Kev xa Khoom
Kwv yees 95% ntawm glycazide khi rau cov ntshav protein. Qhov ntim ntawm kev xa tawm yog li 30 litres.Kev noj cov tshuaj Diabeton ® MV hauv ib koob ntawm 60 mg ib hnub ib zaug ua rau muaj kev saib xyuas ntawm kev ua tau zoo ntawm gliclazide hauv cov ntshav ntshav ntau dua 24 teev.

Kev zom zaub mov
Gliclazide yog metabolized feem ntau hauv lub siab. Tsis muaj cov metabolites hauv lub plasma ntshav.

Chaw Sau Ntawv
Glyclazide raug tso tawm feem ntau los ntawm lub raum: kev nthuav tawm yog nqa tawm hauv kev tsim cov tshuaj metabolites, tsawg dua li 1% yog raug tawm los ntawm lub raum tsis hloov. Ib nrab-lub neej ntawm gliclazide yog nruab nrab li ntawm 12 txog 20 teev.

Kab Zuag
Cov kev sib raug zoo ntawm cov koob tshuaj tiv thaiv (txog 120 mg) thiab thaj chaw hauv qab qhov nkhaus pharmacokinetic "xav txog - sijhawm" yog kab.

Tshwj xeeb cov neeg
Qub neeg
Hauv cov neeg laus, tsis muaj kev hloov pauv ntau hauv cov qauv pharmacokinetic.

INDICATIONS RAU SIV

Hom 2 mob ntshav qab zib mellitus nrog cov tsis muaj txiaj ntsig ntawm kev kho zaub mov noj, ua kom lub cev thiab yuag poob.
Kev tiv thaiv ntawm cov teeb meem mob ntshav qab zib mellitus: txo kev pheej hmoo ntawm microvascular (nephropathy, retinopathy) thiab macrovascular muaj teeb meem (myocardial infarction, mob stroke) hauv cov neeg mob hom 2 mob ntshav qab zib mellitus los ntawm kev tswj hwm zoo glycemic.

cov tshuaj tiv thaiv kab mob rau gliclazide, lwm yam sulfonylurea derivatives, sulfonamides lossis rau cov neeg raug tshem tawm uas yog ib feem ntawm cov tshuaj,
ntshav qab zib hom 1
ketoacidosis, mob ntshav qab zib precoma, mob ntshav qab zib coma,
mob raum lossis mob siab tsis txaus (hauv qhov no, nws raug pom zoo kom siv cov tshuaj insulin),
noj miconazole (saib Ntu "Kev cuam tshuam nrog lwm cov tshuaj"),
cev xeeb tub thiab lub sijhawm lactation (saib ntu "Cev xeeb tub thiab lub sijhawm lactation"),
hnub nyoog txog 18 xyoo.

Vim tias qhov tseeb ntawm kev npaj muaj lactose, Diabeton MV tsis pom zoo rau cov neeg mob uas tsis muaj ntshav qab zib, galactosemia, qabzib-galactose malabsorption.
Nws tsis pom zoo kom siv los ua ke nrog phenylbutazone lossis danazole (saib ntu "Kev cuam tshuam nrog lwm cov tshuaj").

Nrog saib xyuas
Cov neeg laus, tsis xwm yeem thiab / lossis tsis noj zaub mov tsis zoo, qabzib-6-phosphate dehydrogenase tsis txaus, cov kab mob hnyav ntawm cov hlab plawv, hypothyroidism, adrenal lossis pituitary tsis txaus, lub raum thiab / lossis daim siab tsis ua haujlwm, ntev kho nrog glucocorticosteroids (GCS), kev quav dej cawv.

PREGNANCY THIAB BREAST-FEEDING PERIOD

Cev xeeb tub
Tsis muaj kev paub nrog gliclazide thaum cev xeeb tub. Cov ntaub ntawv hais txog kev siv lwm cov sulfonylurea derivatives thaum cev xeeb tub muaj tsawg.
Hauv kev kawm txog cov tsiaj hauv chaw sim, teratogenic cov teebmeem ntawm gliclazide tsis tau txheeb xyuas.
Txhawm rau kom txo cov kev pheej hmoo ntawm lub cev tsis xwm yeem, kev tswj hwm qib siab (kev kho kom haum) ntawm ntshav qab zib mellitus yog qhov tsim nyog. Qhov ncauj hypoglycemic qhov ncauj thaum cev xeeb tub tsis siv.
Cov tshuaj Insulin yog cov tshuaj xaiv rau kev kho mob ntshav qab zib hauv cov poj niam cev xeeb tub.
Nws raug nquahu kom hloov qhov kev noj tshuaj ntawm qhov ncauj hypoglycemic nrog insulin txoj kev kho ob leeg nyob rau hauv rooj plaub ntawm kev npaj cev xeeb tub, thiab yog tias cev xeeb tub tau tshwm sim thaum noj cov tshuaj.

Lactation
Ua rau hauv kev txiav txim siab tsis muaj cov ntaub ntawv hais txog kev noj cov gliclazide hauv cov kua mis thiab kev pheej hmoo ntawm kev noj qab haus huv neonatal hypoglycemia, kev pub mis niam yog contraindicated thaum kho cov tshuaj.

KHAWV KOOB THIAB KEV COB QHIA

DAIM AV RAU QHOV KEV SIV RAU XWB RAU KEV TIV THAIV NEEG.

Qhov koob pom zoo yuav tsum noj ntawm qhov ncauj, 1 zaug nyob rau ib hnub, nyiam dua thaum noj tshais.
Qhov tshuaj txhua hnub yuav yog 30-120 mg (1 /₂ -2 ntsiav tshuaj) hauv ib qho tshuaj xwb.
Nws raug nquahu kom nqos ib qho ntsiav tshuaj lossis ib nrab ntawm lub ntsiav tshuaj tag nrho yam tsis ntxo lossis tsoo.
Yog tias koj plam ib lossis ntau dua ntawm cov tshuaj, koj tsis tuaj yeem siv ntau dua koob tshuaj ntxiv, koob tshuaj uas ploj lawm yuav tsum noj nyob rau hnub tom ntej.
Ib yam li lwm cov tshuaj ntshav hypoglycemic, lub koob tshuaj ntawm txhua qhov tshuaj yuav tsum tau xaiv ib tus zuj zus, nyob ntawm kev saib xyuas cov ntshav qabzib thiab HbA1c.

Thawj koob tshuaj
Thawj koob tshuaj pom zoo (suav nrog rau cov neeg mob laus, ≥ 65 xyoo) yog 30 mg rau ib hnub (1 /₂ ntsiav tshuaj).
Thaum muaj kev tswjhwm txaus, cov tshuaj hauv qhov tshuaj no tuaj yeem siv rau kev kho kho. Nrog kev tswj tsis tau glycemic txaus, koob tshuaj txhua hnub tuaj yeem raug nce ntxiv mus rau 60, 90 lossis 120 mg.
Qhov koob tshuaj nce siab yog ua tau tsis tau ntxov dua tom qab 1 lub hlis ntawm kev siv tshuaj kho nyob rau ntawm lub koob tshuaj uas tau qhia dhau los. Qhov tshwj tsis yog cov neeg mob uas cov ntshav qabzib concentration tsis tau txo tom qab 2 lub lis piam ntawm kev kho. Nyob rau hauv cov xwm txheej zoo li no, cov koob tshuaj yuav raug nce 2 lub lis piam tom qab pib ua haujlwm.
Qhov siab tshaj plaws uas pom zoo hauv kev siv tshuaj txhua hnub yog 120 mg.
1 ntsiav tshuaj ntawm cov tshuaj Diabeton ® MV cov ntsiav tshuaj nrog kev hloov pauv ntawm 60 mg yog sib npaug rau 2 ntsiav tshuaj ntawm Diabeton ® MV ntsiav tshuaj nrog kev hloov pauv ntawm 30 mg Lub xub ntiag ntawm qhov kev tshaj tawm ntawm 60 mg ntsiav tshuaj tso cai rau koj faib cov ntsiav tshuaj thiab noj ib koob tshuaj 30 mg txhua hnub (1 /₂ ntsiav tshuaj 60 mg), thiab yog tias tsim nyog 90 mg (1 thiab 1 /₂ 60 mg ntsiav tshuaj).

Txoj kev hloov los ntawm kev noj tshuaj Diabeton ® ntsiav tshuaj ntawm 80 mg rau cov tshuaj Diabeton tablets MV ntsiav tshuaj nrog kev hloov pauv tawm ntawm 60 mg 1 ntsiav tshuaj ntawm cov tshuaj Diabeton ® 80 mg tuaj yeem hloov pauv 1 /₂ cov ntsiav tshuaj nrog hloov kho tso tawm Diabeton ® MV 60 mg. Thaum hloov mus rau cov neeg mob ntshav qab zib ® 80 mg rau Diabeton D MV, ceev faj kev tswj glycemic yog pom zoo.

Hloov los ntawm kev noj lwm qhov tshuaj hypoglycemic rau cov tshuaj Diabeton tablets MV ntsiav tshuaj nrog kev hloov pauv ntawm 60 mg
Cov tshuaj Diabeton ® MV cov ntsiav tshuaj nrog kev hloov pauv ntawm 60 mg tuaj yeem siv hloov lwm lub tshuaj hypoglycemic rau kev tswj hwm qhov ncauj. Thaum hloov mus rau cov neeg mob tau txais lwm cov tshuaj hypoglycemic rau kev tswj hwm qhov ncauj rau Diabeton ® MV, lawv cov koob tshuaj thiab ib nrab ntawm lub neej yuav tsum raug coj los txiav txim. Raws li txoj cai, lub sijhawm hloov pauv tsis tas yuav tsum muaj. Qhov muab tshuaj thawj zaug yuav tsum yog 30 mg thiab tom qab ntawv ua raws li lub siab ntawm cov ntshav qabzib.
Thaum Tus Mob Ntshav Qab Zib ® MV hloov pauv nrog sulfonylurea derivatives nrog ib nrab lub neej ntev kom tsis txhob mob ntshav qab zib vim tshwm sim los ntawm cov nyhuv ntxiv ntawm ob tus kab mob hypoglycemic, koj tuaj yeem nres noj lawv rau ob peb hnub. Koob tshuaj xub thawj ntawm cov tshuaj Diabeton ® MV kuj tseem yog 30 mg (1 /₂ ntsiav tshuaj 60 mg) thiab, yog tias tsim nyog, tuaj yeem nce ntxiv yav tom ntej, raws li tau piav qhia saum toj no.

Ua ke siv nrog lwm cov tshuaj hypoglycemic
Tus mob ntshav qab zib ® MV tuaj yeem siv ua ke nrog biguanidins, alpha-glucosidase inhibitors lossis insulin. Nrog kev tswj tsis tau glycemic tsis txaus, kev kho tshuaj insulin ntxiv yuav tsum tau txiav txim siab nrog kev saib xyuas mob siab.

Cov neeg laus cov neeg mob
Kev txhaj tshuaj rau cov neeg mob uas laus dua 65 xyoos tsis tas yuav tsum tau ua.

Cov neeg mob raum tsis ua haujlwm
Cov txiaj ntsig ntawm kev tshawb fawb pom tau hais tias kev kho kom haum rau hauv cov neeg mob uas tsis tshua mob mus rau lub raum tsis ua haujlwm. Pom zoo kev saib xyuas kev mob nkeeg.

Cov neeg mob Yuav Muaj Kev Phom Sij Hypoglycemia
Hauv cov neeg mob uas muaj kev pheej hmoo txhim kho hypoglycemia (noj tsis txaus lossis tsis noj zaub mov noj tsis txaus, mob hnyav lossis nyiaj tsis txaus ntawm cov kabmob endocrine - pituitary thiab adrenal tsis txaus, hypothyroidism, tshem tawm cov glucocorticosteroids (GCS) tom qab siv sijhawm ntev thiab / lossis kev tswj hwm hauv siab, mob ntshav siab ntau vascular system - muaj kev mob plawv mob ntshav siab, mob hnyav carotid arteriosclerosis, mob atherosclerosis zoo tshaj plaws, nws raug nquahu kom siv tshuaj tsawg kawg (30 mg) ntawm kev npaj ua ntej ata Diabeton ® MV.

Tiv thaiv tus mob ntshav qab zib muaj teeb meem
Txhawm rau kom muaj kev sib deev ntau ntxiv glycemic tswj, koj tuaj yeem maj mam nce qhov ntau ntawm cov tshuaj Diabeton ® MV rau 120 mg / hnub ntxiv rau kev noj haus thiab kev tawm dag zog kom ua tiav cov hom phiaj ntawm HbA1c. Nco ntsoov cov kev pheej hmoo ntawm kev txhim kho hypoglycemia. Tsis tas li ntawd, lwm cov tshuaj hypoglycemic, piv txwv li, metformin, alpha-glucosidase inhibitor, thiazolidinedione derivative lossis insulin, tuaj yeem raug ntxiv rau kev kho mob.

Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo.
Cov ntaub ntawv hais txog kev ua haujlwm zoo thiab muaj kev nyab xeeb rau cov tshuaj hauv cov menyuam yaus thiab cov hluas hnub nyoog qis dua 18 xyoo tsis muaj.

Tej yam tsis zoo
Muab cov kev paub nrog gliclazide, koj yuav tsum nco ntsoov txog qhov tseem ntawm kev tsim cov kev mob tshwm sim hauv qab no.

Kev ntshav siab
Zoo li lwm yam tshuaj ntawm sulfonylurea pab pawg, cov tshuaj mob ntshav qab zib ® MV tuaj yeem ua rau lub ntsej muag ntshav qis thaum muaj zaub mov tsis xwm yeem thiab tshwj xeeb yog tias qhov khoom noj tsis zoo. Cov tsos mob tshwm sim ntawm tus mob ntshav qab zib: mob taub hau, tshaib plab, xeev siab, ntuav, ntau zog, pw tsaug zog, chim siab, ntxhov siab, tsis tshua mloog siab, ncua kev tiv thaiv, kev nyuaj siab, tsis meej pem, tsis pom kev thiab hais tsis tau lus, tsis meej pem, tshee, paresis, tswj tus kheej , zoo nkaus li tsis paub pab, tsis pom kev, hnov qab, kiv taub hau, tsis muaj zog, nriaj, ua kom zoo nkauj, ua kom zoo nkauj, ua pa nyuaj, tsaug zog, ploj mus ntawm qhov tsis nco qab nrog txoj kev loj hlob ntawm coma, mus txog rau qhov tuag.
Cov tshuaj tiv thaiv Andrenergic tseem tuaj yeem sau tseg: nce hws, "tawv nqaij" tawv nqaij, ntxhov siab, tachycardia, nce ntshav siab, palpitations, arrhythmia, thiab angina pectoris.

Raws li txoj cai, cov tsos mob hypoglycemia tau nres los ntawm kev noj cov khoom noj carbohydrates (qab zib). Noj cov khoom qab zib yog qhov ua tsis tau txiaj ntsig. Tawm tsam keeb kwm ntawm lwm cov sulfonylurea derivatives, rov qab kho cov ntshav qog ntshav tau sau tseg tom qab nws tau txais txiaj ntsig zoo.

Lwm yam phiv

Los ntawm cov hnyuv: mob plab, xeev siab, ntuav, raws plab, cem quav. Kev noj cov tshuaj thaum noj tshais zam cov tsos mob no lossis txo qis.

Cov kev mob tshwm sim nram qab no tsis tshua pom:

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: xoo pob khaus, khaus, urticaria, Quincke's edema, erythema, maculopapular pob sawv hlwv, muaj kev tsis haum tshuaj (xws li Stevens-Jones syndrome thiab tshuaj lom epidermal necrolysis).

Los ntawm cov kabmob hemopoietic plab thiab kabmob lymphatic: hematological ntshawv siab (ntshav liab, leukopenia, thrombocytopenia, granulocytopenia) muaj tsawg. Raws li txoj cai, cov xwm txheej no thim rov qab yog tias kev kho tsis ua hauj lwm.

Nyob rau ib feem ntawm daim siab thiab kais plab: kev ua si ntau ntxiv ntawm cov kab mob "siab" (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, kab mob siab (mob cais tawm). Yog tias muaj tus mob daj ntseg cholestatic tshwm sim, kev kho yuav tsum tsis ua mus ntxiv.

Cov xwm txheej no feem ntau yuav thim rov qab yog tias kev kho tsis ua hauj lwm.

Los ntawm sab ntawm cov khoom ntawm lub zeem muag: kev tsis pom kev txawv txav tuaj yeem tshwm sim vim hloov pauv hauv cov ntshav cov piam thaj, tshwj xeeb tshaj yog thaum pib kho.

Phiv los mus rau sulfonylurea derivatives: raws li nrog lwm cov sulfonylurea derivatives, cov kev mob tshwm sim hauv qab no tau sau tseg: erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, kev tsis haum vasculitis, hyponatremia. Muaj kev nce ntxiv hauv cov kev ua haujlwm ntawm "daim siab" ua rau lub siab ua haujlwm tsis zoo, piv txwv li, nrog kev loj hlob ntawm cholestasis thiab jaundice thiab mob siab, tshwm sim tsawg dua lub sijhawm tom qab tsis kho sulfonylurea npaj, tab sis qee kis tau ua rau lub siab ua rau lub siab tsis ua haujlwm.

Sab kev tshwm sim muaj nyob rau hauv kev soj ntsuam kuaj mob
Hauv qhov kev kawm ADVANCE, muaj qhov sib txawv me me hauv qhov nquag ntawm ntau qhov xwm txheej tsis zoo ntawm ob pawg ntawm cov neeg mob. Tsis muaj cov ntaub ntawv kev nyab xeeb tshiab tau txais. Tsawg tsawg tus neeg mob tau muaj ntshav qab zib ntau ntau, tab sis qhov xwm txheej ntawm tag nrho cov neeg mob ntshav qab zib tsawg tsawg. Qhov tshwm sim ntawm cov ntshav qog nqaij hlav hauv ntshav siab glycemic tswj pab pawg tau siab dua nyob hauv pawg glycemic tswj pawg. Feem ntau qhov tshwm sim ntawm hypoglycemia nyob rau hauv kev tswj hwm glycemic tau tsom kwm tawm tsam keeb kwm ntawm cov tshuaj insulin kho.

OVERDOSE
Yog tias muaj kev noj tshuaj ntau dhau ntawm sulfonylurea derivatives, hypoglycemia yuav loj hlob tuaj.
Yog tias koj muaj cov tsos mob me me ntawm lub cev tsis muaj ntshav tsis muaj qhov tsis nco qab lossis cov tsos mob neurological, koj yuav tsum nce cov khoom noj carbohydrates nrog cov zaub mov, txo qhov ntau ntawm cov tshuaj thiab / lossis hloov cov zaub mov noj. Kaw kev tshuaj xyuas mob ntawm tus neeg mob yuav tsum tau txuas ntxiv mus kom txog thaum muaj kev ntseeg siab tias tsis muaj dab tsi ua rau nws noj qab haus huv. Tej zaum qhov kev txhim kho ntawm cov kev mob hypoglycemic hnyav, nrog kev tsis nco qab, ntog lossis lwm yam mob puas siab ntsws. Yog tias cov tsos mob no tshwm sim, yuav tsum tau txais kev kho mob ceev ceev thiab tau mus pw hauv tsev kho mob sai.
Yog tias qhov mob ntshav qab zib ua rau nws tsis nco qab lossis yog xav tias tsam tus neeg mob tau txhaj tshuaj nrog 50 ml ntawm 20-30% kev daws ntawm dextrose (qabzib). Tom qab ntawv, ib qho 10% dextrose kev daws teeb meem yog muab tshuaj txo qis kom tswj tau cov ntshav qabzib siab siab tshaj 1 g / L. Kev ua tib zoo soj ntsuam cov ntshav qabzib hauv qib siab thiab soj ntsuam ntawm tus neeg mob yuav tsum tau nqa tawm tsawg kawg 48 teev tom qab. Tom qab lub sijhawm no, nyob ntawm tus neeg mob lub sijhawm, tus kws kho mob txiav txim siab txog qhov xav tau kev tshuaj xyuas ntxiv. Kev lim ntshav tsis muaj txiaj ntsig vim yog qhov tseeb khi ntawm gliclazide ntxiv rau cov ntshav protein.

INTERACTION NROG LWM COV MEDICINES

1) Tshuaj thiab cov tshuaj uas ua rau muaj kev pheej hmoo ntawm hypoglycemia:
(txhim kho cov nyhuv ntawm gliclazide)

Contraindicated kev sib txuas ua ke
- Miconazole (nrog kev tswj hwm kev tswj hwm thiab thaum siv cov kua rau ntawm lub qhov ncauj mucosa): txhim kho cov nyhuv hypoglycemic ntawm gliclazide (hypoglycemia yuav dhau mus txog thaum tsis nco qab).

Tsis pom zoo kev sib txuas ua ke
- Phenylbutazone (kev tswj hwm kev tswj hwm): ua kom lub ntsej muag hypoglycemic nyhuv ntawm sulfonylurea derivatives (hloov lawv los ntawm kev sib txuas lus nrog plasma protein thiab / lossis qeeb lawv qhov kev tawm ntawm lub cev).
Nws zoo dua yog siv lwm cov tshuaj tiv thaiv kev tiv thaiv. Yog tias phenylbutazone tsim nyog, tus neeg mob yuav tsum ceeb toom txog qhov xav tau kev tswj hwm glycemic. Yog tias tsim nyog, cov koob tshuaj ntawm cov tshuaj ntshav qab zib ® MV yuav tsum tau kho thaum noj phenylbutazone thiab tom qab nws.
- Ethanol : txhim kho cov ntshav qog ntshav qab zib, inhibiting kev tawm tsam, tuaj yeem pab txhawb kev txhim kho hypoglycemic coma. Nws yog ib qho tsim nyog kom tsis kam noj tshuaj, uas suav nrog kev haus cawv thiab haus cawv.

Ceev faj
Glyclazide ua ke nrog qee yam tshuaj: lwm yam kab mob hypoglycemic (insulin, acarbose, metformin, thiazolidinidiones, dipeptidyl peptidase-4 inhibitors, GLP-1 agonists), beta-adrenergic blocking agents, fluconazole, angiotensin-antiplatelet inhibitors, caprimentin-tshuaj kho mob,₂-histamine receptors, monoamine oxidase inhibitors, sulfonamides, clarithromycin thiab non-steroidal anti-inflammatory drugs) yog nrog los ntawm kev nce ntxiv hauv cov nyhuv hypoglycemic thiab kev pheej hmoo ntawm hypoglycemia.

2) Cov tshuaj uas ua rau cov ntshav ntxiv ntshav:
(cov nyhuv tsis muaj zog ntawm gliclazide)

- Danazole: muaj ib tug mob ntshav qab zib ua hauj lwm. Yog tias noj cov tshuaj no yog qhov tsim nyog, tus neeg mob tau qhia kom ua tib zoo saib ntshav ntshav qab zib. Yog tias tsim nyog, kev sib koom tes ua ke ntawm cov tshuaj, nws raug nquahu tias koob tshuaj hypoglycemic tus neeg sawv cev yuav tsum tau xaiv ob qho tib si thaum tswj hwm ntawm danazol thiab tom qab nws tshem tawm.

Ceev faj
- Chlorpromazine (antipsychotic) : hauv cov koob tshuaj ntau (ntau dua 100 mg ib hnub twg) nce qhov kev mloog zoo ntawm cov piam thaj hauv cov ntshav, txo qis cov kua dej ntawm cov tshuaj insulin.
Ua tib zoo glycemic tswj hwm yog pom zoo. Yog tias tsim nyog, kev sib koom tes tswj hwm tshuaj, nws raug pom zoo tias yuav tsum tau xaiv cov koob tshuaj hypoglycemic, ob qho tib si thaum tswj hwm kev tawm tsam thiab tom qab tshem tawm.
- GKS (cov kev thov ua haujlwm hauv ib cheeb tsam thiab thaj chaw: thaj tsam rau ntawm daim tawv nqaij, lub cev ntawm lub qhov quav) thiab tetracosactide: ua rau kom cov ntshav qabzib ntau ntxiv nrog kev txhim kho ketoacidosis (txo qis hauv kam rau ua carbohydrates). Saib xyuas glycemic tswj hwm yog pom zoo, tshwj xeeb tshaj yog thaum pib kho. Yog tias nws yuav tsum tau noj tshuaj ua ke, kev hloov kho tshuaj ntawm ib tus neeg sawv cev hypoglycemic yuav tsum tau ob qho tib si thaum tswj hwm GCS thiab tom qab lawv tshem tawm.
- Ritodrin, salbutamol, terbutaline (kev tswj hwm hauv lub cev): beta-2 adrenergic agonists nce ntshav qabzib concentration.
Kev saib xyuas tshwj xeeb yuav tsum tau them rau qhov tseem ceeb ntawm kev tswj hwm tus kheej-glycemic. Yog tias tsim nyog, nws raug nquahu kom hloov tus neeg mob mus rau kev kho mob insulin.

3) Kev sib xyaw ua ke yuav tsum tau muab los suav

- Anticoagulants (Xws li warfarin)
Cov peev txheej ntawm sulfonylureas tuaj yeem txhim kho cov nyhuv ntawm anticoagulants thaum noj ua ke. Cov tshuaj tiv thaiv Anticoagulant yuav tsum tau kho kom haum.

COV LUS QHIA TSHWJ XEEB

Kev ntshav siab
Thaum noj sulfonylurea derivatives, suav nrog gliclazide, kev mob ntshav qab zib qog ntshav yuav tshwm sim, qee qhov mob ntawm kev mob hnyav thiab mob ntev, yuav tsum tau pw hauv tsev kho mob thiab tso tshuaj rau cov tshuaj kho kom zoo rau ob peb hnub (saib ntu "Cov Kev Phiv").
Cov tshuaj tuaj yeem tsuas yog kho rau cov neeg mob uas lawv noj mov tsis tu ncua thiab suav nrog pluas tshais. Nws yog ib qho tseem ceeb heev kom muaj kev noj haus nrog cov carbohydrates nrog zaub mov, txij li kev pheej hmoo ntawm kev txhim kho hypoglycemia nce nrog cov zaub mov tsis xwm yeem lossis tsis txaus, zoo li thaum noj cov zaub mov tsis zoo rau hauv carbohydrates.
Kev mob ntshav qab zib feem ntau pib txhim kho nrog cov zaub mov tsis muaj calorie, tom qab ua haujlwm ntev lossis ua kom ib ce muaj zog, tom qab haus cawv, lossis thaum noj ntau yam tshuaj hypoglycemic nyob rau tib lub sijhawm.
Feem ntau, cov tsos mob ntawm hypoglycemia ploj tom qab noj mov uas muaj nplua nuj hauv carbohydrates (xws li qab zib). Nws yuav tsum tau yug hauv siab tias kev noj cov khoom qab zib tsis pab tshem tawm cov tsos mob hypoglycemic. Cov kev paub ntawm kev siv lwm cov sulfonylurea derivatives qhia tau hais tias hypoglycemia tuaj yeem rov tshwm sim dua txawm tias pib kho tus mob no. Nyob rau hauv rooj plaub hypoglycemic cov tsos mob tau tshaj tawm los yog kav ntev, txawm tias muaj kev txhim kho ib ntus tom qab noj zaub mov nplua nuj hauv carbohydrates, kev kho mob xwm txheej ceev yog tsim nyog, mus txog tsev kho mob.
Txhawm rau kom zam dhau kev txhim kho hypoglycemia, kev ceev faj xaiv cov tshuaj thiab kev noj tshuaj yog qhov tsim nyog, nrog rau kev muab tus neeg mob nrog cov ntaub ntawv tiav ntawm kev kho mob.

Ib qho kev pheej hmoo ntawm hypoglycemia ntau tuaj yeem tshwm sim hauv cov xwm txheej hauv qab no:

kev tsis kam lossis tsis muaj peev xwm ntawm tus neeg mob (tshwj xeeb yog cov neeg laus) kom ua raws li kws kho mob tau sau tseg thiab saib xyuas nws tus mob,
Kev noj zaub mov tsis txaus thiab tsis xwm yeem, hla zaub mov noj, yoo mov thiab hloov pauv kev noj zaub mov,
tsis txaus ntawm kev qoj ib ce thiab tus nqi ntawm carbohydrates coj,
lub raum tsis ua hauj lwm
daim siab ua hauj lwm hnyav
noj tshuaj muaj yees Diabeton D MV,
qee cov mob endocrine: mob qog, pituitary thiab adrenal tsis txaus,
kev siv qee cov tshuaj (saib Ntu "Kev cuam tshuam nrog lwm cov tshuaj").

Plaws thiab lub siab ua haujlwm
Hauv cov neeg mob uas muaj mob hepatic thiab / lossis lub raum tsis ua haujlwm, cov chaw muag tshuaj thiab / lossis cov chaw muag tshuaj muaj zog ntawm gliclazide yuav hloov pauv. Lub xeev ntawm hypoglycemia uas tsim kho hauv cov neeg mob no tuaj yeem yog lub sijhawm ntev heev, nyob rau hauv cov xwm txheej zoo li no, kev kho kom sai tsim nyog yog tsim nyog.

Tus Neeg Mob Cov Ntaub Ntawv
Nws yog ib qho tsim nyog yuav tau qhia rau tus neeg mob, nrog rau nws tsev neeg, txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib, nws cov tsos mob thiab cov xwm txheej zoo rau nws txoj kev txhim kho. Yuav tsum qhia rau tus neeg mob txog cov kev pheej hmoo thiab cov txiaj ntsig zoo ntawm txoj kev kho mob uas tau thov.
Tus neeg mob xav tau qhia meej txog qhov tseem ceeb ntawm kev noj haus, kev xav kom ib ce muaj zog thiab soj ntsuam cov ntshav qabzib ntau.

Kev tswj tsis tau glycemic
Kev tswj cov ntshav hauv cov neeg mob uas tau txais kev kho mob hypoglycemic yuav ua kom tsis muaj zog ntawm cov mob hauv qab no: ua npaws, mob, mob kis, lossis phais mob loj. Nrog rau cov mob no, nws kuj yuav tsim nyog los txiav kev kho mob nrog rau cov tshuaj Diabeton ® MV thiab sau tshuaj tawm kho insulin.
Hauv ntau tus neeg mob, qhov ua tau zoo ntawm qhov ncauj hypoglycemic tus neeg sawv cev, suav nrog gliclazide, nyhav poob qis tom qab lub sijhawm ntev los kho. Cov nyhuv no tuaj yeem yog vim ob qho kev hloov zuj zus ntawm tus kabmob thiab txo qis hauv kev kho rau cov tshuaj. Qhov tshwm sim no yog paub tias yog kev tiv thaiv tshuaj thib ob, uas yuav tsum tau qhov txawv ntawm thawj qhov, uas cov tshuaj tsis muab qhov kev cia siab tshwm sim thaum thawj zaug teem tseg. Ua ntej kuaj pom tus neeg mob nrog cov tshuaj tiv thaiv kab mob thib ob, nws yog qhov yuav tsum tau soj ntsuam qhov tsis txaus ntawm kev xaiv koob tshuaj thiab kev ua raws li tus neeg mob lub cev noj haus.

Kev kuaj sim
Yuav kom ntsuam xyuas glycemic tswj, kev txiav txim siab tsis tu ncua ntawm cov ntshav ceev thiab ntshav glycated hemoglobin HbA1c yog qhov pom zoo.
Ib qho ntxiv, nws raug nquahu kom ua qhov kev soj ntsuam tus kheej hauv cov ntshav cov ntshav qabzib ntau.
Sulfonylurea derivatives tuaj yeem ua rau hemolytic anemia nyob rau hauv cov neeg mob uas muaj piam thaj-6-phosphate dehydrogenase tsis txaus. Txij li thaum gliclazide yog sulfonylurea derivative, kev saib xyuas yuav tsum tau ua thaum muab tshuaj rau nws rau cov neeg mob uas muaj glucose-6-phosphate dehydrogenase tsis txaus.
Lub peev xwm ntawm kev muab tshuaj hypoglycemic ntawm lwm pab pawg yuav tsum raug txheeb xyuas.

PAUB TXOG TXOG KEV TSAV TSHEB THIAB TXHUA YAM KEV TXIAV TXIM
Vim tias txoj kev txhim kho hypoglycemia tsim nyog nrog kev siv tshuaj yeeb tshuaj rau tus kab mob ntshav qab zib ® MV, cov neeg mob yuav tsum paub txog cov tsos mob ntawm lub qog ntshav qab zib thiab yuav tsum ceev faj thaum tsav tsheb lossis ua haujlwm ua haujlwm xav tau kev kub ceev ntawm lub cev thiab lub hlwb, tshwj xeeb tshaj yog thaum pib kho.

ISSUE FORM
60 mg hloov kho ntsiav tshuaj
30 ntsiav tshuaj rau ib lub hlwv (PVC / Al), 1 lossis 2 lub hlwv nrog cov lus qhia rau kev siv kho mob hauv pob ntawv los qhia.
Thaum ntim khoom (ntim ntawv) ntawm Lavxias lub tuam txhab LLC Serdix:
30 ntsiav tshuaj rau ib lub hlwv (PVC / Al), 1 lossis 2 lub hlwv nrog cov lus qhia rau kev siv kho mob hauv pob ntawv los qhia.
15 ntsiav tshuaj rau ib lub hlwv (PVC / Al), 2 lossis 4 lub hlwv nrog cov lus qhia rau kev siv tshuaj kho mob hauv pob ntawv los qhia.
Los ntawm ntau lawm hauv Lavxias enterprise LLC Serdix
15 ntsiav tshuaj rau ib lub paug ntawm PVC / Al. Rau 2 lossis 4 lub hlwv nrog cov lus qhia rau kev siv tshuaj kho mob hauv ib pob ntawv ntawm cardboard.

COV NTAUB NTAWV CIA
Cov mob tshwj xeeb tsis tas yuav tsum muaj.
Txhob nyob ze cov me nyuam.

TXIV NEEJ LUB NEEJ
2 xyoos Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

LUS NCO
Los ntawm tshuaj.

Chaw tsim tshuaj paus
Kev Tshuaj Ntsuam (Lab) Servier Kev Lag Luam, Fab Kis
Serdix LLC, Russia

Kev tso npe rau daim ntawv pov thawj pom zoo los ntawm Servier Laboratories, Fab Kis; Servier Industries Labs, Fabkis

"Lub chaw soj nstuam Servier Kev Lag Luam":
905, Txoj kev loj Saran, 45520 Gidey, Fab Kis
905, txoj kev de Saran, 45520 Gidy, Fab Kis

Txog txhua cov lus nug, tiv toj rau Lub Chaw Sawv Cev ntawm JSC "Servier Laboratory".

Sawv cev ntawm JSC "Kuaj Xyuas Ntsuas":
115054, Moscow, Paveletskaya pl. d.2, p. 3

Kev ntim thiab / lossis ntim / hauv ntau lawm ntawm LLC Serdiks, Russia
Serdix LLC:
Russia, Moscow

Diabeton MV: lus qhia rau kev siv (noj thiab hom)

Cov tshuaj yog noj qhov ncauj, ib zaug ib hnub (nyiam dua thaum noj tshais). Nws tsis pom zoo kom zom los yog ntxaws lub ntsiav tshuaj.

Qhov koob tshuaj txhua hnub ntawm Tus Mob Ntshav Qab Zib MV nws txawv ntawm 30 txog 120 mg hauv ib koob. Yog tias koj plam ib lossis ntau hnub ntawm kev kho mob, koj tsis tuaj yeem nce qhov ntxiv rau ntawm koob ntxiv tom ntej.

Cov koob tshuaj ntawm cov tshuaj yog xaiv ib tus zuj zus coj mus rau hauv tus lej ntsuas xws li kev saib xyuas cov piam thaj hauv ntshav thiab qib ntawm glycogemoglobin (HbA1c).

Thaum pib kho mob, Cov Ntshav Qab Zib MV 30 mg rau ib hnub twg tau sau tseg (suav cov neeg laus laus 65 xyoo thiab laus dua). Nrog kev tswjhwm txaus, gliclazide ntawm cov tshuaj no tuaj yeem siv los ua kev kho kev kho mob. Thaum tsis muaj kev tswj hwm glycemic tsis txaus, cov koob tshuaj yuav tau nce ntxiv (ua ntu zus) txog 60 mg, 90 mg lossis 120 mg ib hnub.

Cov koob tshuaj muaj peev xwm nce ntxiv tom qab ib hlis ntawm kev kho mob nrog gliclazide hauv cov tshuaj uas tau muab rau yav dhau los, tshwj tsis yog cov neeg mob hauv cov neeg cov ntshav siab tsis txo tom qab 2 lub lis piam ntawm kev siv tshuaj. Cov neeg mob zoo li no tuaj yeem nce ntxiv tom qab 2 lub lim tiam ntawm kev kho.

Qhov tshuaj ntau tshaj plaws ntawm tus kab mob ntshav qab zib MV yog 120 mg rau ib hnub.

Thaum hloov los ntawm cov tshuaj Diabeton (80 mg ntawm gliclazide) rau Diabeton MV, ib ntsiav tshuaj ntawm Diabeton yog hloov pauv mus rau ib nrab ntsiav tshuaj ntawm Diabeton MV 60 mg. Txoj kev hloov yog nyob ntawm kev tswjhwm glycemic.

Tus mob ntshav qab zib MV tuaj yeem siv ua lwm yam kev tiv thaiv kab mob hauv lub qhov ncauj. Thaum hloov mus rau tus neeg mob, cov koob tshuaj uas tau siv tshuaj hypoglycemic thiab nws ib nrab-lub neej raug coj mus rau hauv tus lej. Feem ntau yuav tsum muaj kev hloov lub sijhawm. Thawj koob tshuaj Diabeton MV yog 30 mg thiab tom qab ntawv yog nyob ntawm cov ntshav qabzib hauv cov ntshav.

Yog tias tus neeg mob tau noj lwm yam sulfonylurea derivatives nrog kev tshem tawm ntev ib nrab-lub neej, nws yuav tsum tau tso tseg kev kho mob rau ob peb hnub thiab tsuas yog tom qab ntawd pib noj ntshav qab zib MV (los tiv thaiv hypoglycemia, uas yuav yog los ntawm cov txiaj ntsig ntxiv ntawm ob hom tshuaj hypoglycemic).

Gliclazide tuaj yeem ua ke nrog alpha-glucosidase inhibitors, insulin lossis biguanidines.

Kev tswj tsis tau zoo glycemic, kev kho tshuaj insulin yog ua tiav ib txhij hauv kev saib xyuas mob.

Rau cov neeg mob hnub nyoog 65 xyoos thiab laus dua, nrog rau cov neeg mob uas mob mentsis mus txog rau lub raum tsis ua hauj lwm, tsis tas yuav txhaj tshuaj.

Hauv cov khoom uas muaj cov txheeb ze contraindications, Diabeton MV yog siv hauv qhov kev tso cai yam tsawg kawg nkaus (30 mg ib hnub twg).

Sab sij huam

plab zom mov: xeev siab, mob plab, ntuav, cem quav lossis zawv plab (noj gliclazide thaum noj tshais minimizes muaj peev xwm ntawm cov tsos mob no tshwm sim),,
mob rau daim siab thiab kab mob: daim siab ua rau daim siab transaminase kev ua haujlwm, raug mob sib cais - mob siab (tsis xav tau kev kho mob ntxiv),
lymphatic system thiab hematopoietic plab hnyuv siab raum: tsis tshua muaj - leukopenia, anemia, granulocytopenia, thrombocytopenia (ploj tom qab tsis siv tshuaj),
tawv nqaij thiab tawv nqaij subcutaneous: tawv nqaij ua pob khaus, erythema, tawm pob, urticaria, maculopapular pob, angioedema, kev tawv ncauj,
cov plab hnyuv siab raum: qhov muag pom kev txawv txav vim qhov hloov pauv hauv cov piam thaj, tshwj xeeb tshaj yog thaum pib kho.

Thaum kho nrog Diabeton MV, mob ntshav qab zib yuav tshwm sim, tshwj xeeb yog noj mov tsis xwm yeem lossis dhia tshais, noj su lossis noj hmo. Cov tsos mob ntawm tus mob ntshav qab zib yog: xeev siab, kev tshaib plab, ntuav, mob taub hau, chim siab, tsis tshua saib siab, nkees, ntxhov siab, qeeb qeeb, pw tsaug zog, ntxhov siab, tshee, xav tias tsis paub pab, kev nyuaj siab, tsis hnov lus thiab tsis pom kev, tswj tus kheej, kev nyuaj siab, paresis, kev tsis hnov qab, kev pom dua lwm tus, txhav, hawb pob, ua pa nyuaj, kiv taub hau, tsis muaj zog, nkees nkees, tsis nco qab, tsis nco qab, tsis nco qab (txog thaum tuag). Cov tshuaj tiv thaiv adrenergic hauv qab no kuj tseem yuav tshwm sim: ntxhov siab vim, hyperhidrosis, tachycardia, palpitations, angina pectoris, tawv nqaij txhaws, nce ntshav siab thiab arrhythmia.

Feem ntau, cov tsos mob ntawm lub qog ntshav qab zib tau ua tiav lawm los ntawm kev nqus ntawm cov piam thaj (carbohydrates). Cov txiv ntoo qab zib yog qhov ua tsis tau zoo. Yog tias tom qab ua tiav zoo ntawm hypoglycemia tus neeg mob yuav siv lwm yam sulfonylurea derivatives, kev rov huam mob tuaj yeem tshwm sim nrog kev rov ua dua. Thaum lub sijhawm ntev los yog mob ntshav qab zib ntau, kev kho mob xwm txheej ceev yog qhov tseem ceeb (nce mus pw hauv tsev kho mob), txawm hais tias muaj txiaj ntsig ntawm cov tsos mob los ntawm kev tswj hwm tus kheej ntawm carbohydrates.

Qee zaum cov tshuaj tuaj yeem ua rau cov kev mob tshwm sim hauv qab no hauv txhua qhov sulfonylurea derivatives: hemolytic anemia, erythrocytopenia, pancytopenia, hyponatremia, agranulocytosis, kev tsis haum vasculitis.

Cov lus qhia tshwj xeeb

Mob ntshav qab zib MV tuaj yeem mob tsuas yog rau cov neeg mob uas tsis hla zaub mov noj thiab ib txwm muaj pluas tshais. Nws yog ib qho tseem ceeb kom khaws cov khoom noj carbohydrates txaus los ntawm cov khoom noj thiab kom tsis txhob noj cov zaub mov uas muaj carb tsawg. Txoj kev pheej hmoo ntawm hypoglycemia nce nyob rau hauv cov xwm txheej hauv qab no:

daim siab ua hauj lwm hnyav
lub raum tsis ua hauj lwm
muaj cov kab mob endocrine (adrenal thiab pituitary tsis txaus, tus mob qog),
cov zaub mov tsis xwm yeem thiab zaub mov tsis zoo, yoo mov, hla zaub mov noj, hloov pauv khoom noj,
tsis txaus sib npaug ntawm tus nqi ntawm cov nyiaj carbohydrates nrog cov zaub mov thiab lub cev ua si,
kev siv cov yeeb tshuaj ib txhij (saib ntu "Txawv Nyiaj Yeeb Tshuaj"),
noj tshuaj ntawm gliclazide,
lub cev tsis tuaj yeem lossis tsis kam lees ntawm tus neeg mob (tshwj xeeb thaum laus) tswj hwm nws tus mob thiab ua raws cov kws kho mob cov lus qhia.

Kev qaug zog ntawm kev tswj tus mob glycemic yog tso cai rau hauv cov neeg mob nrog kev raug mob, kev phais mob hnyav, kis tus mob lossis kub ib ce. Hauv cov rooj plaub no, tshem tawm ntawm Diabeton MV thiab kev tswj hwm ntawm cov tshuaj insulin tej zaum yuav tsum tau ua.

Hauv ntau tus neeg mob, qhov ua tau zoo ntawm hypoglycemic cov neeg sawv cev rau kev tswj hwm qhov ncauj yuav txo qis thaum lub sijhawm (sib ntxiv tshuaj tiv thaiv).

Yeeb tshuaj sib cuam tshuam

Cov nyhuv ntawm gliclazide ua kom zoo dua nrog kev siv ua ke nrog miconazole (qhov kev sib txuam no yog contraindicated, vim nws tuaj yeem ua rau txoj kev loj hlob ntawm coma), phenylbutazone thiab ethanol (cov nyhuv hypoglycemic yog kho kom zoo).

Vim tias qhov kev pheej hmoo ntawm cov ntshav qog ntshav qab zib, Diabeton MV yuav tsum tau siv nrog ceev faj nrog cov tshuaj hauv qab no: Cov tshuaj tiv thaiv hypoglycemic (acarbose, insulin, thiazolidinediones, metformin, dipeptidyl peptidase-4 inhibitors), fluconazole, beta-adrenergic block agents, sulfonamides, angiotensidinerprein tshuaj tiv thaiv kev tiv thaiv, histamine H blockers₂receptors, monoamine oxidase inhibitors.

Cov nyhuv ntawm gliclazide tsis muaj zog danazol (qhov sib xyaw no tsis pom zoo), chlorpromazine, glucocorticosteroids ib txhij nrog tetracosactide thiab beta₂-adrenomimetics. Cov tshuaj no tau siv nrog ceev faj thiab nyob hauv qab kev tswj glycemic.

Gliclazide tuaj yeem txhim kho qhov tshwm sim ntawm anticoagulants.

Cov lus piv txwv ntawm Diabeton MV yog Gliclazide MV, Gliclazide-AKOS, Gliclazide Canon, Gliclazide MV Pharmstandard, Golda MV, Glidiab, Gliklada, Diabetalong, Glidiab MV, Diabefarm, Glyclazid-SZ, Diabinax, Diabefarm MV, thiab lwm yam.

Kev xyuas txog mob ntshav qab zib MV

Cov neeg mob tawm ntau cov kev txheeb xyuas zoo txog Diabeteson MV. Nov yog cov tshuaj uas siv tau zoo uas yuav pab tswj hwm cov ntshav qab zib kom nyob zoo. Gliclazide tsis tshua muaj ua rau ua xua tshwm sim thiab lwm yam kev phiv. Nws yog qhov yooj yim rau kev noj tshuaj, vim tias qhov koob tshuaj txhua hnub yog tsim rau ib qho koob tshuaj. Kev kho mob Diabeton MV yog ib qho tsim nyog xaiv rau kev kho mob insulin.

Kev saib xyuas cov tshuaj, raws li cov neeg mob: kev xav tau kev siv txuas ntxiv, tsis tuaj yeem muab rau cov menyuam yaus, muaj kev pheej hmoo ntawm cov ntshav qog nqaij ntshav nce siab, tus nqi siab, ib leeg coj mus rau gliclazide.