Biphasic insulin lispro yog qhov sib xyaw ua ke ntawm cov tshuaj tiv thaiv kev tsis txaus ntawm insulin lispro (kev npaj nruab nrab ntawm insulin) thiab lispro insulin (kev ua yeeb yam sai li sai tau insulin). Lyspro insulin yog DNA tso tawm cov tshuaj ntawm cov tshuaj insulin ntawm tib neeg, tab sis hauv kev sib piv, nws muaj kev sib txuam ntawm proline thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Lyspro biphasic insulin muaj cov teebmeem anabolic thiab anti-catabolic, tswj cov metabolism hauv qabzib. Nyob rau hauv cov leeg nqaij thiab lwm cov nqaij (tshwj tsis yog lub hlwb), lyspro biphasic insulin ceev cov kev hloov ntawm cov amino acids thiab qabzib rau hauv lub cell, nce cov ntsiab lus ntawm glycogen, fatty acids, glycerol, amino acid noj, txhim kho protein synthesis, inhibits gluconeogenesis, glycogenolysis, ketogenesis, lipolysis, protein catabolism, tso tawm amino acids, txhawb kev tsim cov glycogen los ntawm cov piam thaj hauv lub siab, txhawb kev hloov ntawm cov piam thaj ntau dhau mus ua rog. Lyspro insulin yog biphasic equimolar rau tib neeg cov tshuaj insulin. Lyspro insulin biphasic thaum piv nrog cov tib neeg cov tshuaj insulin yog qhov tshwm sim los ntawm kev pib sai dua, kev pib ua tiav ntawm qhov kawg ntawm lub sijhawm thiab lub sijhawm luv luv ntawm hypoglycemic kev ua si (txog 5 teev). Lyspro biphasic insulin muaj qhov nqus siab thiab pib ua haujlwm sai (15 feeb tom qab kev tswj hwm), tso cai rau nws ua sai sai ua ntej noj mov (15 feeb), tib neeg cov tshuaj insulin raug tswj hauv ib nrab ib teev. Qhov pib ntawm kev ua thiab qhov kev nqus ntawm kev nqus ntawm lyspro biphasic insulin tuaj yeem cuam tshuam los ntawm kev xaiv ntawm thaj chaw ntawm kev tswj hwm thiab lwm yam. Qhov siab tshaj plaws ntawm insulin lyspro biphasic pom ntawm 0.5 thiab 2.5 teev, lub sijhawm ua ntawm 3 mus rau 4 teev.
Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm lyspro biphasic insulin yog nyob ntawm qhov chaw txhaj tshuaj (tus ncej, plab, pob tw), qhov ntim ntawm cov tshuaj insulin ua rau, qhov tshuaj ntawm insulin hauv tshuaj thiab lwm yam. Lyspro insulin biphasic tau faib tsis ncaj nruab nrab ntawm cov ntaub so ntswg. Lyspro biphasic insulin tsis hla qhov tso hniav thiab tso rau hauv niam mis. Lyspro biphasic insulin yog rhuav tshem los ntawm insulinase feem ntau yog nyob hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum (30 - 80%).

Yam 1 mob ntshav qab zib mellitus, tshwj xeeb nrog kev tsis nkag siab rau lwm cov insulins, postprandial hyperglycemia, uas tsis tuaj yeem kho los ntawm lwm cov insulins: mob subcutaneous insulin tsis kam (nrawm hauv zos kev cuam tshuam ntawm insulin).
Hom 2 mob ntshav qab zib mellitus nrog kev tsis haum ntawm lwm yam insulins, nrog kev tawm tsam cov tshuaj tiv thaiv ntshav qab zib hauv qhov ncauj, nrog kev ua haujlwm, cov kab mob sib kis.

Txoj kev siv cov tshuaj insulin lyspro biphasic thiab koob tshuaj

Lyspro biphasic insulin yog muab tshuaj subcutaneously. Cov koob tshuaj tau teeb tsa ib leeg zuj zus raws li theem ntawm glycemia.
Kev txhaj tshuaj yuav tsum tau ua rau subcutaneously hauv lub xub pwg, pob tw, lub duav, thiab lub plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj ib hlis ib zaug. Nrog kev tswj hwm subcutaneous, kev saib xyuas yuav tsum tau saib xyuas kom tsis txhob nkag mus rau cov ntshav ntshav. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.
Kev tswj hwm ntawm lyspro biphasic insulin yog qhov tsis lees txais.
Yog tias tsim nyog, Lyspro biphasic insulin tuaj yeem muab nrog kev sib xyaw nrog sulfonylureas rau kev tswj hwm qhov ncauj lossis nrog ntev li kev npaj tshuaj insulin.
Hauv cov neeg mob uas lub cev tsis zoo ua haujlwm ntawm lub raum thiab / lossis daim siab, qhov ntau ntawm lub cev insulin nce ntxiv, thiab qhov xav tau nws tuaj yeem txo qis, yog li ntawd, nws yog qhov yuav tsum tau ua tib zoo tswj hwm qib ntawm glycemia thiab kho cov koob tshuaj insulin.
Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam nruj kev noj haus thiab cov txheej txheem ntawm kev coj ua npaj rau koob tshuaj siv.
Thaum hloov cov neeg mob los ntawm kev ua yeeb yam sai sai ntawm cov tsiaj keeb kwm mus rau lyspro biphasic insulin, yuav tsum tau txhaj koob tshuaj. Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis insulin npaj nrog lub npe lag luam sib txawv yuav tsum tshwm sim nyob rau hauv kev saib xyuas mob nkeeg nruj. Hloov chaw ntawm cov neeg mob uas tau txais insulin hauv ib hnub ntau dua 100 IU los ntawm ib hom tshuaj insulin mus rau lwm tus yuav tsum tau nqa tawm hauv tsev kho mob. Hloov pauv ntawm kev ua ub no, chaw tsim khoom, hom, hom, thiab / lossis kev tsim tawm ntawm cov kua dej yuav xav tau kev hloov kho koob tshuaj.
Cov tsos mob ua ntej ntawm hypoglycemia thaum tswj hwm ntawm tib neeg cov tshuaj insulin hauv qee cov neeg mob tej zaum yuav tsawg dua los yog txawv ntawm cov uas tau pom thaum tswj hwm tsiaj insulin. Nrog kev ua haujlwm ntawm cov ntshav qabzib hauv lub cev, piv txwv li, nrog kev kho mob hnyav nrog insulin, tag nrho lossis qee cov tsos mob ntawm cov ua ntej ntawm hypoglycemia yuav ploj, hais txog qhov twg cov neeg mob yuav tsum tau ceeb toom. Cov tsos mob ua ntej ntawm lub ntsej muag hypoglycemia yuav tsis tshua pom zoo lossis hloov pauv nrog lub sijhawm ntev ntawm mob ntshav qab zib mellitus, mob ntshav qab zib neuropathy, kho nrog lwm yam tshuaj.
Kev siv cov tshuaj uas tsis txaus lossis tshem tawm txoj kev kho, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib hom 1, tuaj yeem ua rau hyperetcemia thiab ntshav qab zib ketoacidosis (mob uas muaj feem yuav ua rau tuag taus).
Kev xav tau ntawm insulin tuaj yeem nce nrog kev mob siab kev xav, kis kab mob, nce ntxiv ntawm cov khoom noj carbohydrates hauv cov zaub mov, kev siv tshuaj ntxiv nrog hyperglycemic kev ua si (glucocorticosteroids, thyroid hormones, thiazide diuretics, tshuaj tiv thaiv tsis tau thiab lwm yam).
Qhov xav tau rau insulin tuaj yeem txo nrog qhov txo qis hauv cov khoom noj carbohydrates hauv cov zaub mov, daim siab thiab / lossis lub raum tsis ua haujlwm, kev tsis txaus ntawm lub qog adrenal, lub plab lossis lub qog ua haujlwm, ua kom lub cev muaj zog, siv cov tshuaj ntxiv nrog cov kev ua haujlwm hypoglycemic (tsis xaiv beta-blockers, monoamine oxidase inhibitors, sulfonamides thiab lwm tus).
Kev kho ntawm cov koob tshuaj insulin kuj tseem xav tau nrog kev nce ntxiv hauv kev ua haujlwm lossis nrog kev hloov pauv ntawm ib txwm noj zaub mov.
Cov neeg mob ntshav qab zib tuaj yeem nres qhov mob ntshav qab zib tsawg uas lawv xav los ntawm kev noj cov piam thaj thiab cov zaub mov uas muaj cov carbohydrates (koj yuav tsum muaj tsawg kawg 20 g suab thaj nrog koj). Hais txog qhov hloov pauv hypoglycemia yuav tsum ceeb toom los ntawm tus kws kho mob uas tuaj koom, los daws qhov teeb meem ntawm qhov yuav tsum tau kho ntawm kev kho.
Thaum siv cov tshuaj insulin lyspro biphasic ua ke nrog kev npaj ntawm thiazolidinedione pab pawg, qhov kev pheej hmoo ntawm kev txhim kho edema thiab mob plawv tsis ua haujlwm nce, tshwj xeeb tshaj yog nyob rau cov neeg mob pathology ntawm cov hlab plawv thiab muaj cov kev pheej hmoo rau lub plawv tsis ua haujlwm.
Nrog hyperglycemia lossis hypoglycemia hauv tus neeg mob, kev ceev ntawm lub cev psychomotor thiab kev mloog zoo yuav txo qis, uas tuaj yeem ua rau muaj kev phom sij nyob rau hauv cov xwm txheej uas cov peev xwm no tsim nyog tshwj xeeb (piv txwv li tsav tsheb, tshuab). Cov neeg mob yuav tsum tau ceev faj kom tsis txhob txhim kho hypoglycemia lossis hyperglycemia thaum ua cov haujlwm uas yuav tsum muaj kev xav ntau ntxiv thiab ceev ntawm cov kev xav psychomotor (nrog rau kev tsav tsheb, cov tshuab).Qhov tseem ceeb tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev loj hlob sai ntawm hypoglycemia lossis nrog cov tsos mob tsis tuaj lossis me, ua ntej ntawm hypoglycemia. Hauv cov xwm txheej zoo li no, tus kws kho mob yuav tsum soj ntsuam qhov ua tau ntawm tus neeg mob ua cov haujlwm uas yuav tsum muaj kev xav ntau ntxiv thiab ceev ntawm cov kev xav psychomotor (suav nrog kev tsav tsheb, cov tshuab)

Qauv Khoos Kas-Kho Mob Tshooj 1

Ua liaj ua teb. Kev sib xyaw ntawm lyspro insulin - kev ua yeeb yam sai sai thiab kev tiv thaiv tshuaj tiv thaiv ntawm lyspro insulin - nruab nrab ua yeeb yam insulin. Lyspro insulin yog qhov tso tawm DNA ntawm tib neeg cov tshuaj insulin; nws txawv ntawm nws los ntawm kev rov qab los ntawm proline thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Regulates ntshav qabzib metabolism, muaj cov teebmeem anabolic. Hauv cov leeg nqaij thiab lwm cov nqaij (muaj qhov tsis suav ntawm lub hlwb) nws ua kom sai ntawm kev hloov pauv ntawm cov piam thaj thiab amino acids mus rau hauv lub cell, txhawb txoj kev tsim cov glycogen los ntawm cov piam thaj hauv lub siab, ua rau gluconeogenesis thiab txhawb kev hloov pauv ntawm cov piam thaj mus rau cov rog. Equimolar rau tib neeg cov tshuaj insulin. Piv nrog tib neeg cov tshuaj insulin, nws muaj qhov tshwm sim ntawm kev pib sai dua, kev pib ua tiav ntawm qhov siab kawg thiab lub sijhawm luv dua ntawm kev ua haujlwm hypoglycemic (txog 5 teev). Kev pib sai ntawm kev nqis tes ua (15 feeb tom qab kev tswj hwm) cuam tshuam nrog kev nqus siab thiab tso cai rau nws ua sai sai ua ntej noj mov (15 feeb) - tib neeg cov tshuaj insulin raug tswj hauv 30 feeb. Kev xaiv ntawm qhov chaw txhaj tshuaj thiab lwm yam tuaj yeem cuam tshuam tus nqi ntawm kev nqus thiab pib ntawm nws cov kev ua. Qhov siab tshaj plaws tau pom ntawm 0.5 thiab 2.5 teev, lub sijhawm ua ntawm 3-4 teev.

Cov Khoom Qhia. Hom 1 mob ntshav qab zib mellitus, tshwj xeeb tshaj yog nrog kev tsis nkag siab ntawm lwm cov insulins, postprandial hyperglycemia uas tsis tuaj yeem kho los ntawm lwm cov insulins: mob subcutaneous insulin tsis kam (nrawm hauv zos kev cuam tshuam ntawm insulin). Hom 2 mob ntshav qab zib mellitus - nyob rau hauv kis ntawm tsis kam mus rau qhov ncauj hypoglycemic tshuaj, nyob rau hauv kev ua txhaum ntawm kev nqus ntawm lwm cov insulins, thaum lub sijhawm ua haujlwm, cov kabmob sib kis.

Cov Yuav Tsum Muaj Kev ua haujlwm tsis txaus ntseeg, kev ua ntshav qab zib, insulinoma.

Tsuas tshuaj Cov koob tshuaj tau txiav txim siab ib tus zuj zus nyob ntawm theem ntawm glycemia.

Kev sib xyaw 25% insulin lispro thiab 75% kev tiv thaiv tshuaj tiv thaiv yuav tsum tau tsuas yog muab s / c, feem ntau 15 feeb ua ntej noj mov.

Yog tias tsim nyog, koj tuaj yeem nkag mus nrog kev siv tshuaj insulin kom ntev los yog nrog sulfonylureas rau kev tswj hwm qhov ncauj.

Kev txhaj tshuaj yuav tsum tau ua s / c hauv lub xub pwg, lub duav, lub duav lossis lub plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom qhov chaw qub siv tsis ntau tshaj 1 zaug hauv ib hlis. Nrog s / c tswj hwm, kev saib xyuas yuav tsum tau ua kom tsis txhob nkag rau cov ntshav ntshav.

Hauv cov neeg mob lub raum thiab / lossis daim siab ua haujlwm, lub siab ntawm cov ntshav insulin nce ntxiv, thiab qhov xav tau nws tuaj yeem txo qis, uas yuav tsum tau ceev faj soj ntsuam ntawm theem ntawm glycemia thiab koob tshuaj kho mob ntawm insulin.

Sab sij huam. Kev tsis haum tshuaj (urticaria, angioedema - ua npaws, ua tsis taus pa, ntshav tsawg), lipodystrophy, ua rau muaj qhov tsis zoo ntawm lub sijhawm (feem ntau hauv cov neeg mob uas tsis tau txais insulin yav dhau los), hypoglycemia, hypoglycemic coma.

Noj ntau dhau. Cov tsos mob: tsaug zog, tawm hws, tawm hws, tawm hws, tsis pom kev, tachycardia, tshee tshee, tshaib plab, ntxhov siab, mob plab nyob rau hauv lub qhov ncauj, pallor ntawm daim tawv nqaij, mob taub hau, tshee tshee, ntuav, tsaug zog, pw tsaug zog, ntshai, ntxhov siab, chim siab, txawv txav, qhov tsis paub tseeb txog kev txav chaw, tsis hnov ​​lus thiab pom lub zeem muag, tsis meej pem, hypoglycemic coma, nriaj.

Kev Kho Mob: yog tias tus neeg mob nco qab, dextrose raug kho qhov ncauj, s / c, iv lossis iv txhaj tshuaj glucagon lossis iv hypertonic dextrose tov.Nrog rau kev txhim kho lub ntsej muag tsis nco qab, 20-40 ml (txog 100 ml) ntawm 40% dextrose kev daws teeb meem yog txhaj tshuaj rau hauv tus dej mus rau hauv tus neeg mob kom txog thaum tus neeg mob tawm ntawm lub cev tsis nco qab.

Kev sib txuam. Cov tshuaj tsis sib haum nrog kev daws teeb meem ntawm lwm cov tshuaj.

Cov nyhuv hypoglycemic yog txhim kho los ntawm sulfonamides (suav nrog qhov ncauj tshuaj hypoglycemic, sulfonamides), MAO inhibitors (suav nrog furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, NSAIDs (suav nrog salicylates), anabolic (suav nrog stanozolol, oxandrolone, methandrostenolone), androgens, bromocriptine, tetracyclines, clofibrate, ketoconazole, mebendazole, theophylline, cyclophosphamide, phenfluramine, Li + kev npaj, pyridoxine, quinidine, quinine, chloroquinine.

Glucagon, somatropin, corticosteroids, tshuaj tiv thaiv qhov ncauj, estrogens, thiazide thiab voj diuretics, BMKK, cov thyroid hormones, heparin, sulfinpyrazone, sympathomimetics, danazole, tricyclic antidepressants, clonidinin, calcitonin, antonidinotin, antagonists, ankylrogen, antagonists, cov tshuaj tiv thaiv kab mob, antonium epinephrine blockers H₁histamine receptors.

Beta-blockers, reserpine, octreotide, pentamidine tuaj yeem txhim kho ob qho tib si thiab ua rau cov nyhuv tsis muaj zog hypoglycemic ntawm insulin.

Cov lus qhia tshwj xeeb. Cov kev ntawm cov thawj coj tswj hwm rau daim ntawv ntau npaum siv yuav tsum tau nruj siv.

Thaum hloov cov neeg mob los ntawm kev ua yeeb yam sai ntawm cov tsiaj keeb kwm rau insulin lispro, yuav tsum tau txhaj koob tshuaj. Kev hloov chaw ntawm cov neeg mob tau txais cov tshuaj insulin nyob rau hauv ib hnub ntau dua 100 units los ntawm ib hom tshuaj insulin rau lwm tus yog pom zoo kom nqa tawm hauv tsev kho mob.

Qhov xav tau ntawm cov tshuaj insulin tuaj yeem nce ntxiv thaum muaj kab mob kis, nrog kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov khoom noj carbohydrates hauv zaub mov, thaum ntxiv kev noj tshuaj ntxiv nrog hyperglycemic kev ua si (cov thyroid hormones, GCS, qhov ncauj tiv thaiv kab mob, thiazide diuretics).

Qhov xav tau ntawm cov tshuaj insulin tuaj yeem txo nrog lub raum thiab / lossis lub siab ua haujlwm, nrog qhov txo qis hauv cov khoom noj hauv cov zaub mov, nrog kev tawm dag zog lub cev, thaum ntxiv kev noj tshuaj nrog hypoglycemic kev ua si (MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides).

Kev ntsuam xyuas kev txhim kho hypoglycemia tuaj yeem cuam tshuam cov peev xwm ntawm cov neeg mob koom tes hauv kev khiav tsheb, nrog rau kev saib xyuas cov tshuab thiab tshuab.

Cov neeg mob ntshav qab zib tuaj yeem nres cov ntshav qabzib uas tau txais los ntawm lawv los ntawm kev noj cov piam thaj lossis zaub mov ntau hauv carbohydrates (Nws raug pom zoo tias koj ib txwm muaj tsawg kawg 20 g suab thaj nrog koj). Nws yog ib qho tsim nyog yuav tsum tau qhia rau tus kws kho mob uas tau tuaj kawm txog qhov hloov pauv hypoglycemia txhawm rau daws qhov teeb meem ntawm qhov xav tau ntawm kev kho mob kho.

Qhov kev xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab nce hauv ntu thib ob - thib peb lub hlis. Thaum yug menyuam thiab tam sim ntawd tom qab lawv, xav tau cov tshuaj insulin tuaj yeem txo qis.

Lub xeev tso npe ntawm cov tshuaj. Daim ntawv tshaj tawm raug cai: hauv 2 ntim. M: Medical Council, 2009. - Feem 2, ntu 1 - 568 s., Tshooj 2 - 560 s.

Dosage daim ntawv

Ncua rau lub subcutaneous tswj ntawm 100 IU / ml 3 ml

1 ml ntawm kev tshem tawm muaj

cov tshuaj heev - tshuaj insulin lispro 100 IU, (3.5 mg)

zam txim: sodium hydrogen phosphate heptahydrate, glycerol, phenol kua, methacresol, protamine sulfate, zinc oxide (hauv Zn ++), sodium hydroxide 10% kev daws rau kho pH, lossis 10% hydrochloric acid rau kho pH, dej rau kev txhaj tshuaj.

Ib qho kev tshem tawm dawb, thaum sawv ntsug, exfoliates rau hauv qhov meej, tsis muaj xim lossis yuav luag tsis muaj xim supernatant thiab dawb nag lossis daus. Cov nag lossis daus tau yooj yim resuspended nrog maj mam co

Cev xeeb tub thiab lactation

Ntau cov ntaub ntawv hais txog kev siv tshuaj insulin lispro thaum cev xeeb tub qhia tias qhov tsis muaj qhov xav tsis zoo ntawm cov tshuaj rau cev xeeb tub, qhov xwm txheej ntawm tus menyuam hauv plab thiab cov menyuam yug tshiab. Thaum cev xeeb tub, nws yog ib qho tseem ceeb heev kom tswj tau zoo hauv cov neeg mob uas tau txais kev kho mob insulin. Qhov xav tau rau insulin feem ntau poob qis hauv thawj peb hlis ntawm cev xeeb tub thiab nce hauv qib thib ob thiab thib peb. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau. Cov neeg mob ntshav qab zib yuav tsum qhia lawv tus kws kho mob txog kev xeeb tub los yog nws cov phiaj xwm. Rau cov poj niam uas mob ntshav qab zib mellitus, yuav tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum lub sijhawm pub niam mis.
Phiv los ntawm insulin lyspro biphasic
Kev tsis haum tshuaj (liab liab, o, khaus ntawm qhov chaw txhaj tshuaj, angioedema, dav dav txhaus, ua pa nyuaj, ntshav nce siab, nce tawm hws, urticaria, kub ib ce, txo ntshav siab, ua tsis taus pa), lipodystrophy, edema, qhov tsis zoo hloov pauv, hypoglycemia, ntshav qab zib tsawg (suav nrog kev tuag).

Kev cuam tshuam ntawm insulin lispro biphasic nrog lwm yam tshuaj

Lyspro insulin biphasic yog tshuaj tsis sib haum nrog kev daws ntawm lwm yam tshuaj.
Cov nyhuv hypoglycemic ntawm lyspro biphasic insulin yog txhim kho los ntawm sulfonamides (suav nrog qhov ncauj tshuaj hypoglycemic, sulfanilamides), carbonic anhydrase inhibitors, monoamine oxidase inhibitors (suav nrog procarbazine, furazolidone, selegiline), angiotensin hloov enzyme antioxidative, androgen antioxidants thiab anabolic steroids (suav nrog oxandrolone, stanozolol, methandrostenolone), tetracyclines, captopril, enalapril, b omokriptin, clofibrate, mebendazole, ketoconazole, theophylline, fenfluramine, cyclophosphamide, lithium npaj, quinidine, octreotide, guanethidine, pyridoxine, receptor antagonists ntawm angiotensin II, chloroquine, quinine, ethanol thiab etanolsoderzhaschie txhais tau tias.
Cov nyhuv hypoglycemic ntawm lyspro biphasic insulin yog tsis muaj zog los ntawm somatropin, glucagon, glucocorticosteroids, estrogens, qhov ncauj tiv thaiv kab mob, qeeb calcium calcium blockers, thiazide thiab voj diuretics, cov thyroid hormones, sulfin pyrazone, hepatin, sympathomimetics, antidepressants, antimetidimetinazide calcium, morphine, nicotine, tshuaj maj, phenytoin, chlorprotixen, salbutamol, terbutaline, ritodrin, nicotinic acid, H1-histamine receptor blockers, tsim tawm dnye phenothiazines, Isoniazid, epinephrine.
Beta-blockers, octreotide, reserpine, pentamidine tuaj yeem ob leeg txhim kho thiab ua kom cov ntshav tsis haum ntawm lyspro biphasic insulin.
Beta-adrenergic thaiv cov kab mob, clonidine, reserpine, thaum siv ua ke nrog biphasic insulin lyspro, tuaj yeem zais qhov tshwm sim ntawm cov tsos mob ntawm cov qog ntshav qab zib.
Yog tias nws yuav tsum tau siv tshuaj nrog lyspro biphasic insulin, koj yuav tsum sab laj nrog koj tus kws kho mob.

Noj ntau dhau

Yog hais tias muaj ntau dhau ntawm cov tshuaj insulin nrog lyspro biphasic, mob ntshav qab zib tsawg, uas nrog cov tsos mob li no: tawm hws, nkees, nce tawm hws, profuse hws, tachycardia, palpitations, tshee tshee, ntxhov siab, kev tshaib kev nqhis, tawv nqaij hauv lub qhov ncauj, mob taub hau, daj ntseg, tshee, tshee tshee, ntuav, pw tsis tsaug zog, nyuaj siab lub siab, ntshai, txob taus, tsis ruaj siab ntawm kev txav, kev coj tus cwj pwm txawv, hais lus thiab tsis pom kev, tsis meej pem, nriaj teeb meem, mob ntshav qab zib tsis xeev (tuag taus th sij hawm).Hauv qee qhov xwm txheej, piv txwv li, nrog lub sijhawm ntev los ntawm tus kabmob lossis nrog kev soj ntsuam mob ntshav qab zib mellitus, cov tsos mob ntawm cov ua ntej ntawm hypoglycemia tuaj yeem hloov pauv.
Cov ntshav qog ntshav qis me me feem ntau tuaj yeem nres los ntawm kev noj ntawm cov piam thaj lossis cov piam thaj, thiab koj yuav tau kho qhov ntsuas tshuaj ntawm insulin, kev siv dag zog lossis kev noj haus. Kev kho ntawm cov ntshav qog nruab nrab yuav tuaj yeem nqa tawm los ntawm kev siv tshuaj subcutaneous lossis intramuscular ntawm glucagon, nrog ntxiv kev noj haus ntawm carbohydrates. Cov mob ntshav qab zib tsawg kawg yog tso tseg los ntawm cov tshuaj intramuscular lossis subcutaneous ntawm glucagon lossis kev tso ntshav ntawm lub zog ntawm cov ntshav qabzib, nrog rau qhov ua kom lub ntsej muag tsis hnov ​​qab, 20 - 40 ml (txog 100 ml) ntawm 40% dextrose tov yog txhaj rau qhov mob kom txog thaum tus neeg mob tsis nco qab. Tom qab nws rov qab nco qab, tus neeg mob yuav tsum tau muab cov zaub mov uas muaj nplua mias nyob rau hauv kom thiaj li zam dhau qhov kev rov qab txhim kho ntshav qab zib. Yuav tsum tau txais kev noj haus ntxiv carbohydrate thiab kev soj ntsuam cov neeg mob, vim tias qhov rov qab ua kom tsis txhob mob hypoglycemia yog ua tau.

Tus yam ntxwv dav

Lub npe lag luam rau cov tshuaj yog Humalog Mix. Nws yog nce raws li ib qho kab xev ntawm tib neeg cov kua dej. Cov tshuaj muaj cov nyhuv hypoglycemic, pab kom nrawm rau kev ua kom zoo ntawm cov piam thaj, thiab kuj tswj cov txheej txheem ntawm nws qhov kev tso tawm. Cov cuab yeej yog kev ua haujlwm ob-theem txhaj tshuaj.

Ntxiv rau cov tshuaj yeeb dej caw tseem ceeb, muaj pes tsawg leeg muaj cov khoom sib xyaw ua ke:

• metacresol
• glycerol
• sodium hydroxide nyob rau hauv daim ntawv ntawm tov (los yog hydrochloric acid),
• zinc oxide
• sodium heptahydrate hydrogen phosphate,
• dej.

Txhawm rau siv cov tshuaj no, koj xav tau kev teem caij ntsib kws kho mob nrog cov lus qhia meej. Nws tsis tuaj yeem yuav tsum kho qhov kev noj tshuaj lossis lub sijhawm siv rau ntawm koj tus kheej.

Pharmacological kev ua thiab kev ntsuas

Qhov kev ua haujlwm ntawm hom insulin no zoo ib yam li lwm yam tshuaj rau hauv insulin. Kev nkag mus rau hauv lub cev, cov tshuaj muaj tshuaj txuam nrog kev ua haujlwm ntawm cov cell ua ke, yog li txhawb qhov nqus ntawm cov piam thaj.

Cov txheej txheem ntawm nws nqus los ntawm plasma thiab faib tawm hauv cov nqaij yog nrawm. Qhov no yog lub luag haujlwm ntawm insulin Lizpro nyob rau hauv kev cai ntawm qab zib.

Qhov thib ob ntawm nws cov nyhuv rau lub cev yog qhov txo qis hauv cov piam thaj los ntawm daim siab ua haujlwm. Hauv qhov no, ntau dhau ntawm cov piam thaj tsis nkag rau cov ntshav. Raws li qhov no, nws tuaj yeem hais tias qhov tshuaj Humalog muaj cov nyhuv hypoglycemic nyob rau hauv ob qho kev qhia.

Qhov insulin hom no ua haujlwm sai thiab ua haujlwm 15 feeb tom qab kev txhaj tshuaj. Qhov no txhais tau hais tias cov khoom no tau nqus sai sai los ntawm lub cev. Vim tias cov yam ntxwv no, nws raug tso cai rau siv cov tshuaj yuav luag ua ntej noj mov.

Tus nqi ntawm kev nqus tau cuam tshuam los ntawm qhov chaw txhaj tshuaj. Yog li, koj yuav tsum tau txhaj tshuaj, tsom rau cov lus qhia rau cov tshuaj.

Nws yog qhov sib npaug tseem ceeb kom ua raws li cov lus pom zoo rau Lizpro insulin thaum txiav txim siab ntawm nws txoj kev siv. Cov tshuaj muaj cov nyhuv zoo, yog li nws siv tsuas yog tso cai raws li kev taw qhia. Yog tias koj siv cov tshuaj no yam tsis tsim nyog, koj tuaj yeem ua kev puas tsuaj rau koj lub cev.

Cov ntsiab lus rau kev teem caij Humalog muaj xws li:

• thawj hom ntshav qab zib
• hyperglycemia, cov tsos mob ntawm uas tsis abate nrog kev siv lwm yam tshuaj,
• hom ob ntawm cov ntshav qab zib mellitus (hauv qhov tsis muaj tshwm sim los ntawm kev siv tshuaj yeeb rau kev tswj hwm qhov ncauj),
• kev npaj phais mob ntshav qab zib rau cov neeg mob ntshav qab zib,
• qhov tshwm sim ntawm random pathological mob uas ua rau cov ntshav qab zib tsis txaus,
• lwm hom insulin tsis haum.

Tab sis txawm hais tias muaj kev taw qhia txog kev noj cov tshuaj no, tus kws kho mob yuav tsum kuaj xyuas tus neeg mob thiab paub tseeb tias tsis muaj kev sib txuam thiab kev tsim nyog ntawm kev kho mob.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Humalog yog tsim nyob rau hauv daim ntawv ntawm kev daws rau cov leeg (iv) thiab subcutaneous (s / c) kev tswj hwm: tsis muaj xim, pob tshab (hauv cov duab lag luam ntawm 3 ml, hauv cov hlwv ntim ntawm 5 cartridges, hauv cov duab los qhia 1 pob sawv hlwv, hauv QuickPen syringe cwjmem rau hauv uas daim cartridges muaj 3 ml ntawm cov tshuaj tov tau muab ntim rau hauv cov thawv ntawv ntawm 5 daim syringe cwjmem.

Cov lus sib xyaw ntawm 1 ml ntawm cov tshuaj:

• cov tshuaj nquag: insulin lispro - 100 ME,
• Lub cev ntu: dej rau kev txhaj tshuaj - txog 1 ml, tov sodium hydroxide 10% thiab (lossis) daws hydrochloric acid 10% - txog pH 7-8, sodium hydrogen phosphate heptahydrate - 0.00188 g, zinc oxide - rau Zn ++ 0.000 0197 g , metacresol - 0.00315 g, glycerin (glycerol) - 0.016 g.

Tsuas tshuaj thiab tswj hwm

Qhov ntau thiab tsawg ntawm cov tshuaj tau txiav txim los ntawm tus kws kho mob ib leeg zuj zus, ua rau qhov kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Qhov kev daws teeb meem yog txhaj tshuaj iv - yog tias tsim nyog, yog muaj mob ntawm cov kab mob pathologies, ketoacidosis, ntawm kev ua haujlwm thiab tom qab lub sijhawm txiav txim siab, s / c - nyob rau hauv daim ntawv ntawm kev txhaj tshuaj lossis ncua kev hno (dhau ntawm lub taub dej insulin) hauv plab, pob tw, lub duav lossis xub pwg, tsis yog cia cov khoom lag luam nkag rau hauv cov hlab ntshav. Cov chaw txhaj tshuaj hloov pauv txhua zaus, yog li thaj chaw tsis raug siv ntau tshaj 1 zaug hauv ib hlis. Tom qab tswj hwm, qhov chaw txhaj tshuaj tsis tuaj yeem raug muab tua pov tseg.

Hauv txhua kis, hom kev tswj hwm tus kheej tau teeb tsa tus kheej. Cov lus qhia yog nqa tawm sai ua ntej noj mov, tab sis kev siv cov tshuaj raug tso cai sai tom qab noj mov.

Npaj rau kev tswj hwm tshuaj

Ua ntej siv, txoj kev daws teeb meem tau soj ntsuam rau cov khoom tsis haum, ua kom nruj, staining thiab tuab. Tsuas yog siv cov xim tsis muaj xim thiab meej nyob rau hauv chav tsev.

Ua ntej kev txhaj tshuaj, ntxuav koj ob txhais tes kom huv, xaiv thiab so qhov chaw rau kev txhaj tshuaj. Tom ntej no, lub hau raug tshem tawm ntawm rab koob, daim tawv nqaij yog rub los yog sau rau hauv daim loj, rab koob tau tso rau hauv nws thiab lub pob yog nias. Tom qab ntawd, rab koob tau raug tshem tawm thiab rau ob peb vib nas this qhov chaw txhaj tshuaj yog ua tib zoo nias nrog paj rwb pas nrig. Los ntawm txoj kev tiv thaiv lub hau ntawm rab koob nws tau muab tso tseg thiab pov tseg.

Ua ntej siv Humalog nyob rau hauv qhov siv cwj mem-tshuaj (lub taub roj), QuickPen yuav tsum nyeem cov lus qhia rau kev siv.

Qhov kev txhaj tshuaj IV yog tau ua raws li kev kuaj mob ib txwm muaj, piv txwv, IV bolus txhaj tshuaj lossis hla ntawm cov tshuab infusion. Kev nquag saib xyuas cov ntshav qabzib yog qhov tseem ceeb.

Qhov kev ruaj khov ntawm txoj kev nqus ntshav nrog kev tsim kho ntawm 0.1-1 IU rau 1 ml ntawm insulin lispro hauv 5% dextrose lossis 0.9% sodium chloride tov rau 2 hnub yog muab thaum khaws cia hauv chav tsev kub.

Rau nqa tawm sc infusions, Disetronic thiab Minimed twj tsim rau cov tshuaj insulin infusions tuaj yeem siv. Nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov khw muag cov lus qhia thiab ua raws cov cai ntawm asepticism thaum sib txuas cov kab ke. Txhua txhua 2 hnub lawv hloov lub kaw lus rau txoj kev lis ntshav. Txoj kev lis ntshav nrog hypoglycemic rov qab nres yog kom txog thaum nws daws tau lawm. Thaum muaj cov ntshav qabzib tsawg nyob hauv cov ntshav, tus neeg mob yuav tsum sab laj nrog kws kho mob los txiav txim siab txo qis lossis tso tseg cov tshuaj insulin.

Kev nce siab ntxiv hauv cov ntshav qabzib hauv lub ntsej muag tuaj yeem pom nrog txoj kev txhaws rau txoj kev lis ntshav lossis lub mis tsis ua haujlwm. Yog tias ib qho kev ua txhaum ntawm cov tshuaj insulin xa mus ua rau xav tias yog vim li cas kev nce ntxiv hauv cov piam thaj, tus neeg mob yuav tsum ua raws li cov lus qhia ntawm lub chaw tsim khoom thiab qhia rau tus kws kho mob (yog tias tsim nyog).

Humalog thaum siv lub twj tso kua mis tsis tuaj yeem tov nrog lwm cov insulins.

QuickPen insulin cwj mem muaj 3 ml ntawm tshuaj nrog ib qho haujlwm ntawm 100 IU hauv 1 ml. 1-60 chav tsev ntawm insulin tuaj yeem muab rau ib qho kev txhaj tshuaj. Cov koob tshuaj tuaj yeem tsim nrog qhov tseeb ntawm ib chav. Yog tias ntau cov koog tau tsim tsa, cov koob tshuaj tuaj yeem hloov kho uas tsis muaj qhov poob ntawm insulin.

Lub koob txhaj tshuaj tsuas yog siv los ntawm ib tus neeg mob xwb, cov koob tshiab yuav tsum tau siv rau txhua qhov kev txhaj tshuaj. Tsis txhob siv cov txhaj tshuaj yog tias ib qho ntawm nws feem raug piam lossis tawg. Tus neeg mob yuav tsum nqa lub tshuab nqus dej tas li yog poob lossis puas.

Cov neeg mob uas tsis pom kev tsis pom kev lossis tsis pom kev zoo tsis pom zoo kom siv cov koob tshuaj tsis tas yuav tsum tau txais kev pab zoo los ntawm cov neeg pom kom tau kawm siv nws.

Ua ntej txhua txoj kev txhaj tshuaj, nws yog ib qho tseem ceeb kom paub meej tias lub hnub tas sij hawm uas tau qhia ntawm daim ntawv lo tsis tau tas sij hawm thiab tias hom insulin tseeb muaj nyob hauv lub koob. Hauv qhov no, nws tsis pom zoo kom tshem daim ntawv lo ntawm nws.

Cov xim ntawm cov xim khawm ceev ntawm QuickPen syringe cwj mem yog grey, nws phim cov xim ntawm cov kab txaij rau ntawm nws daim ntawv lo thiab cov tshuaj insulin siv.

Ua ntej siv cov hno, koj yuav tsum xyuas kom tseeb tias rab koob tau txuas ntawm nws. Tom qab siv, rab koob raug tshem tawm thiab pov tseg. Cov xaum xaum yuav tsis khaws cia nrog rab koob txuas rau nws, vim qhov no yuav ua rau huab cua npuas los ua rau hauv lub thawv tshuaj.

Thaum sau ntawv yuav ib koob tshuaj dhau ntawm 60 units, ob qhov kev txhaj tshuaj.

Txhawm rau kuaj cov tshuaj insulin hauv daim cartridge, koj yuav tsum tau taw lub taub hau nrog lub taub ntawm rab koob nce thiab pom tus naj npawb ntawm cov seem ntawm cov tshuaj insulin rau ntawm cov nplai ntawm lub pob tshab yas dhos. Qhov ntsuas no tsis yog siv los teeb lub koob tshuaj.

Txhawm rau kom tshem lub hau ntawm lub injector, koj yuav tsum rub nws. Yog tias muaj teeb meem tshwm sim, ua tib zoo tig lub hau moos ntawm moos thiab counterclockwise, thiab tom qab ntawd rub nws.

Txhua lub sijhawm ua ntej txhaj tshuaj, lawv tshawb xyuas cov tshuaj insulin kom tsawg, vim tias tsis muaj nws koj tuaj yeem tau txais insulin ntau dhau lossis muaj ntau dhau. Txhawm rau tshuaj xyuas, tshem tawm lub hau sab nraud thiab sab hauv ntawm rab koob, los ntawm tig lub pob koob tshuaj, 2 chav nyob yog teeb tsa, lub taub tso ntshav tau ncaj qha mus sab hauv thiab khob qhov rooj ntawm lub laub kom cov pa tag nrho cov pa tuaj sau nyob rau sab saud. Tom qab ntawd nias lub pob koob tshuaj kom txog thaum nws nres thiab tus lej 0 tshwm nyob rau hauv lub qhov ntsuas qhov ntsuas tshuaj. Tuav lub khawm nyob rau hauv txoj haujlwm recessed, maj mam suav mus rau 5, lub sijhawm no lub pob tshuaj insulin yuav tsum tshwm sim thaum kawg ntawm rab koob. Yog hais tias qhov ua kom yuam kev ntawm insulin tsis tshwm sim, lub koob tau hloov nrog lub tshiab thiab rov qab xeem yog nqa tawm.

Kev tswj hwm tshuaj

• tshem lub hau ntawm cwj mem syringe
• nrog ib qho qhwv ntaws nrog dej cawv, so lub roj hmab disc ntawm qhov kawg ntawm lub cartridge,
• muab rab koob tso rau hauv lub hau ncaj ncaj rau ntawm lub axis ntawm lub taub hau thiab ntsuas hau kom txog thaum nws txuas kiag li,
• los ntawm kev hloov cov koob tshuaj khawm, qhov yuav tsum tau muaj ntawm cov tau teeb tsa,
• tshem lub hau ntawm rab koob thiab ntxig rau hauv qab daim tawv nqaij,
• nrog koj tus ntiv tes xoo, nias lub khawm koob tshuaj kom txog thaum nws nres kiag li. Txhawm rau nkag mus rau qhov tshuaj tag nrho, tuav lub pob thiab maj mam suav rau 5,
• lub koob raug tshem tawm hauv qab ntawm daim tawv nqaij,
• xyuas qhov ntsuas qhov koob tshuaj - yog tias nws muaj tus lej 0 rau nws, cov koob tshuaj tau sau tiav lawm,
• ua tib zoo muab lub hau ntim rau ntawm rab koob thiab muab nws rho tawm ntawm cov koob, mam li muab pov tseg.
• muab lub hau kaw rau ntawm tus cwj mem xaum qhuav.

Yog tias tus neeg mob xav tias nws tau siv tag nrho cov tshuaj, tsis tas yuav rov qab noj dua.

Sab sij huam

• feem ntau ntau: hypoglycemia (hauv qhov xwm txheej loj, nws tuaj yeem ua rau kev txhim kho hypoglycemic coma, tshwj tsis yog mob - tuag),
• ua tau: lipodystrophy, kev tsis haum tshuaj hauv zos - o, liab lossis khaus ntawm qhov chaw txhaj tshuaj,
• tsis tshua muaj: muaj kev tsis haum rau lub cev dav dav - nce tawm hws, tachycardia, txo ntshav siab, ua tsis taus pa, kub taub hau, mob caj dab, mob urticaria, khaus thoob plaws lub cev.

Cov lus qhia tshwj xeeb

Hloov chaw ntawm tus neeg mob mus rau lwm lub npe lossis hom tshuaj insulin yog ua tiav los ntawm kev saib xyuas mob nkeeg nruj. Yog tias koj hloov hom kev tsim khoom, hom, hom, hom thiab / lossis kev ua ub no, yuav tau kho kom haum cov koob tshuaj.

Cov tsos mob uas cuam tshuam txog kev txhim kho hypoglycemia tej zaum yuav tsawg tshaj tawm thiab tsis tseem ceeb nrog kev kho mob hnyav nrog insulin, kev muaj sia nyob ntev ntawm ntshav qab zib mellitus, kab mob ntawm cov hlab ntshav tawm tsam tiv thaiv ntshav qab zib mellitus, thiab tib lub sij hawm kho nrog tshuaj, piv txwv li beta-blockers.

Cov tsos mob thaum ntxov ntawm hypoglycemia rau cov neeg mob hypoglycemic tshua tom qab hloov los ntawm tsiaj insulin rau tib neeg cov tshuaj insulin yuav tsis tshua hnyav lossis txawv ntawm cov uas lawv tau muaj nrog insulin yav dhau los thaum kho.

Thaum tsis nco qab mob hyperglycemic lossis hypoglycemic tshua, kev loj hlob ntawm qhov tsis nco qab, tsis nco qab, lossis pib ntawm txoj kev tuag yog ua tau. Siv cov tshuaj tsis haum tshuaj lossis tsis tuaj yeem kho kev kho mob, tshwj xeeb tshaj yog rau hom ntshav qab zib hom mellitus, tuaj yeem ua rau kev loj hlob ntawm hyperglycemia thiab ntshav qab zib ketoacidosis, uas muaj peev xwm hem tus neeg mob lub neej.

Hauv lub raum thiab hepatic qhov tsis txaus, nws tuaj yeem txo qhov kev xav tau rau insulin, uas cuam tshuam nrog txo qis ntawm cov tshuaj insulin metabolism thiab gluconeogenesis cov txheej txheem. Hauv kev mob siab ua haujlwm ntev (vim tias muaj peev xwm tiv thaiv cov tshuaj insulin ntau dua), kev nyuaj siab ntxhov siab, kis kab mob, kev nce siab ntawm cov khoom noj carbohydrates hauv zaub mov, qhov xav tau insulin yuav nce ntxiv.

Thaum muaj kev hloov pauv ntawm kev noj zaub mov noj ib txwm thiab muaj dag zog rau lub cev, kev hloov tshuaj ntau dua yuav raug. Thaum ua cov kev tawm dag zog lub cev tam sim ntawd tom qab noj mov, nws muaj peev xwm nce ntxiv ntawm kev pheej hmoo ntawm hypoglycemia. Vim yog lub chaw muag tshuaj ntawm kev ua haujlwm sai ntawm tib neeg cov tshuaj insulin, hypoglycemia yuav tshwm sim thaum ntxov tom qab txhaj tshuaj dua thaum siv cov tshuaj lom neeg insulin.

Thaum sau cov tshuaj insulin npaj nrog qhov sib xyaw ntawm 40 IU hauv 1 ml hauv lub vial, nws tsis tuaj yeem cia cov tshuaj insulin los ntawm daim cartridge nrog cov tshuaj insulin ntawm 100 IU hauv 1 ml siv koob txhaj tshuaj rau insulin nrog rau 40 IU hauv 1 ml.

Kev kho ib txhij nrog insulin npaj nrog tshuaj ntawm thiazolidinedione pab pawg nce qhov kev pheej hmoo ntawm kev txhim kho edema thiab mob plawv tsis ua hauj lwm, tshwj xeeb tshaj yog tiv thaiv cov keeb kwm yav dhau los ntawm kab mob ntawm cov hlab plawv thiab nyob rau ntawm qhov muaj kev pheej hmoo rau mob plawv tsis ua haujlwm.

Cov neeg mob thaum kho yuav tsum ua tib zoo saib xyuas thaum tsav tsheb thiab ua cov haujlwm muaj kev phom sij uas yuav tsum muaj kev saib xyuas ntau dua thiab nrawm rau cov kev puas hlwb.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv ntawm tshuaj / tshuaj rau ntawm insulin lispro nrog kev kho ua ke:

• phenothiazine derivatives, nicotinic acid, lithium carbonate, isoniazid, diazoxide, chlorprotixene, thiazide diuretics, tricyclic antidepressants, beta-2-adrenergic agonists (terbutaline, salbutamol, ritodrin, thiab lwm yam), danazole, thyroid-muaj cov thyroid hormones: qhov heev ntawm nws cov hypoglycemic nyhuv,
• angiotensin II receptor antagonists, octreotide, angiotensin-converting enzyme inhibitors (enapril, captopril), qee cov tshuaj tiv thaiv kab mob (monoamine oxidase inhibitors), tshuaj tua kab mob sulfanilamide, salicylates (acetylsalicylic acid, thiab lwm yam, tshuaj phenolic, tetragenurolinogens, tshuaj tiv thaiv hypoglycrogen ethanol thiab ethanol-muaj cov tshuaj, beta-blockers: nce qhov hnyav ntawm nws cov nyhuv hypoglycemic.

Lyspro insulin tsis tov nrog tsiaj cov tshuaj insulin.

Ua ntej noj lwm yam tshuaj, nws yog ib qho tseem ceeb kom sab laj nrog kws kho mob. Ntawm nws qhov kev pom zoo, cov tshuaj yeeb yaj kiab tuaj yeem siv ua ke nrog cov kua dej hauv tib neeg ntev ntev los yog nrog cov ncauj lus ntawm sulfonylureas.

Cov qauv ntawm Humalog yog Iletin I tsis tu ncua, Iletin II tsis tu ncua, Nruab Nrab SPP, Nruab Nrab HM, Farmasulin.

Cov Cai Siv Tshuaj So

Tso tawm los ntawm kev kho mob.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

Dua li ntawm qhov tseeb hais tias cov kws tshawb fawb tswj tau kom rov ua tiav cov tshuaj insulin molecule, uas tsim tawm hauv tib neeg lub cev, qhov kev ua ntawm cov tshuaj hormones tseem ua rau qeeb qeeb vim lub sijhawm xav kom nqus mus rau hauv cov ntshav. Thawj cov tshuaj ntawm kev ua kom zoo dua yog cov tshuaj insulin Humalog. Nws pib ua haujlwm tau ntev lawm 15 feeb tom qab txhaj tshuaj, yog li ntawd cov suab thaj los ntawm cov ntshav pauv mus rau cov ntaub so ntswg hauv lub sijhawm, thiab txawm tias lub sijhawm luv luv hyperglycemia tsis tshwm sim.

Nws yog ib qho tseem ceeb kom paub! Ib yam tshiab tawm tswv yim los ntawm endocrinologist rau Saib Xyuas Ntshav Qab Zib Ntxiv! Nws tsuas yog tsim nyog txhua hnub.

Piv nrog cov neeg tsim insulins yav dhau los, Humalog qhia tau zoo dua: hauv cov neeg mob, txhua hnub hloov pauv hauv qab zib yog li 22%, glycemic qhov ntsuas tau zoo, tshwj xeeb tshaj yog yav tav su, thiab qhov muaj feem yuav ua rau muaj ntshav siab qeeb tsawg dua. Vim tias qhov nrawm nrawm, tab sis qhov kev txiav txim ruaj khov, qhov insulin no nce hauv kev mob ntshav qab zib.

Qhia me ntsis

Cov lus qhia txog kev siv tshuaj insulin Humalog yog qhov hluav taws xob heev, thiab cov ntu piav qhia txog kev phiv thiab cov lus qhia rau kev siv nyob ntau dua ib kab lus. Cov lus piav qhia ntev ntev uas sib xyaw nrog qee cov tshuaj tau pom los ntawm cov neeg mob yog lus ceeb toom txog kev phom sij ntawm kev coj lawv. Qhov tseeb, txhua yam muaj qhov sib txawv: ib qho loj, cov lus qhia ntxaws ntxaws - cov ntaub ntawv pov thawj ntawm ntau yam kev sim siab tias cov tshuaj no thev taus zoo.

Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los

Mob ntshav qab zib yog qhov ua rau ze li ntawm 80% ntawm tag nrho cov cwj nrag thiab txiav taws. 7 ntawm 10 leej neeg tuag vim txhaws ntawm cov hlab ntsha hauv plawv lossis paj hlwb. Yuav luag txhua qhov teeb meem, qhov laj thawj rau qhov txaus ntshai kawg no yog qhov qub - ntshav qab zib siab.

Cov piam thaj tuaj yeem thiab yuav tsum tau sib khob, tsis muaj dab tsi. Tab sis qhov no tsis kho tus kab mob nws tus kheej, tab sis tsuas yog pab txhawm rau txhawm rau tshawb xyuas, thiab tsis yog qhov ua kom muaj tus kab mob.

Cov tshuaj nkaus xwb uas raug pom zoo rau kev kho mob ntshav qab zib thiab nws kuj yog siv los ntawm endocrinologist hauv lawv txoj haujlwm yog qhov no.

Qhov ua tau zoo ntawm cov tshuaj, suav raws li tus qauv txheej txheem (tus naj npawb ntawm cov neeg mob uas tau zoo mus rau tag nrho cov neeg mob hauv pawg 100 ntawm cov neeg tau txais kev kho mob) yog:

• Li qub ntawm qab zib - 95%
• Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
• Ntaus tau ntawm lub plawv dhia muaj zog - 90%
• Kev tshem tawm ntshav siab - 92%
• Ntxiv dag zog rau nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj - 97%

Cov neeg tsim khoom tsis yog lub koom haum ua lag luam thiab tau nyiaj peev nrog kev txhawb nqa los ntawm lub xeev. Yog li ntawd, tam sim no txhua tus neeg nyob hauv muaj qhov zoo.

Humalogue tau txais kev pom zoo rau kev siv ntau dua 20 xyoo dhau los, thiab tam sim no nws muaj kev ruaj ntseg hais tias cov tshuaj insulin no muaj kev nyab xeeb ntawm kev siv tshuaj. Nws tau txais kev pom zoo rau kev siv los ntawm ob tus neeg laus thiab menyuam yaus, tuaj yeem siv rau txhua tus neeg mob, nrog rau qhov tsis muaj suab yam tshuaj: hom 1 thiab ntshav qab zib hom 2, phais mob pancreatic.

Cov ntaub ntawv dav dav txog qhov Humalogue:

Ntawm cov kev mob tshwm sim, hypoglycemia thiab kev fab tshuaj tsis haum yog feem ntau pom (1-10% ntawm neeg mob ntshav qab zib). Tsawg dua 1% ntawm cov neeg mob tsim muaj lipodystrophy ntawm thaj chaw txhaj tshuaj. Qhov ntau zaus ntawm lwm cov kev tsis sib haum yog tsawg dua 0.1%.

Qhov tseem ceeb tshaj plaws txog Humalog

Nyob hauv tsev, Humalog yog muab subcutaneously siv rab koob xaum qhuav los yog. Yog tias muaj mob loj heev yuav tsum raug tshem tawm, kev tswj hwm cov tshuaj no kuj tuaj yeem ua rau hauv cov chaw kho mob. Hauv qhov no, nquag tswj cov piam thaj yog qhov tsim nyog kom tsis txhob noj ntau dhau.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj yog insulin lispro. Nws txawv ntawm tib neeg cov tshuaj hormones hauv kev npaj cov amino acids hauv cov qauv molecule. Xws li kev hloov kho tsis tiv thaiv cov cell receptors los ntawm kev paub txog cov tshuaj hormones, yog li lawv yooj yim dhau suab thaj rau lawv tus kheej Qhov humalogue tsuas muaj cov tshuaj insulin monomers - ib qho, tsis txuas yam tsis txawv. Vim tias qhov no, nws yog nqus tau nrawm thiab tusyees, pib txo cov piam thaj sai dua li cov tshuaj insulin tsis haum.

Qhov tshuaj tiv thaiv tshuaj yog qhov yeeb tshuaj luv dua li, piv txwv, lossis. Raws li kev faib tawm, nws tau xa mus rau cov tshuaj insulin sib piv nrog cov kev ua kom haum. Qhov pib ntawm nws cov kev ua tau nrawm dua, li 15 feeb, yog li cov neeg mob ntshav qab zib tsis tas tos kom txog thaum cov tshuaj ua haujlwm, tab sis koj tuaj yeem npaj zaub mov noj tom qab txhaj tshuaj. Ua tsaug rau qhov tsis txaus no, nws yuav yooj yim rau kev npaj zaub mov noj, thiab qhov kev pheej hmoo tsis nco qab cov zaub mov tom qab kev txhaj tshuaj yog txo qis dua.

Rau kev tswj cov glycemic zoo, cov neeg sawv cev nrawm yuav tsum tau ua ke nrog kev siv. Tib qho kev zam tsuas yog kev siv lub tshuab nqus dej twj tso kua mis rau ntawm lub sijhawm txuas ntxiv.

Xaiv xaiv

Kev noj tshuaj Humalog ntau nyob ntawm ntau yam thiab txiav txim siab ntawm tus kheej rau txhua tus mob ntshav qab zib. Kev siv cov qauv txheem yog tsis pom zoo, vim tias lawv ua rau kev mob ntshav qab zib hnyav dua. Yog tias tus neeg mob ua raws li cov zaub mov uas tsis muaj carbohydrate tsawg, qhov koob tshuaj ntawm Humalog yuav tsawg dua li cov qauv ntawm kev tswj hwm tuaj yeem muab tau. Hauv qhov no, nws pom zoo kom siv cov tshuaj insulin uas tsis muaj zog tuaj.

Ultrashort cov tshuaj hormones muab cov nyhuv loj tshaj. Thaum hloov mus rau Humalog, nws qhov kev pib noj tshuaj yog xam raws li 40% ntawm kev siv insulin luv luv.Raws li cov txiaj ntsig ntawm glycemia, ntau npaum li cas tau kho. Qhov xav tau qhov nruab nrab ntawm kev npaj rau ib khob cij yog 1-1.5 units.

Cov qauv kev txhaj tshuaj

Lub humalogue yog pricked ua ntej txhua pluas noj, tsawg kawg peb zaug hauv ib hnub Cov. Nyob rau hauv cov ntaub ntawv ntawm cov piam thaj siab, kho cov menyuam hlob nyob nruab nrab ntawm kev txhaj tshuaj tseem ceeb raug tso cai. Cov kev qhia rau kev siv pom zoo xam lub xav tau cov tshuaj insulin raws li cov khoom noj uas tau npaj rau kev noj mov tom ntej. Txog 15 feeb yuav tsum dhau los ntawm kev txhaj tshuaj mus rau cov zaub mov.

Raws li kev txheeb xyuas, lub sijhawm no feem ntau tsawg dua, tshwj xeeb yog thaum tav su, thaum cov tshuaj tiv thaiv insulin tsawg dua. Qhov nqus tus nqi yog nruj me ntsis rau ib tus neeg, nws tuaj yeem raug suav siv rov ua ntsuas ntsuas cov ntshav qab zib sai sai tom qab txhaj. Yog tias cov ntshav qab zib ua rau pom qhov cuam tshuam sai dua li cov lus qhia, lub sijhawm ua ntej noj mov yuav tsum raug txo kom tsawg.

Humalog yog ib qho tshuaj sai tshaj plaws, yog li nws yooj yim siv nws ua kev pabcuam xwm txheej ceev rau cov ntshav qab zib, yog tias tus neeg mob raug hem.

Lub sijhawm ua haujlwm (luv lossis ntev)

Lub ncov ntawm ultrashort insulin yog pom 60 feeb tom qab nws tswj hwm. Lub sijhawm ua haujlwm nyob ntawm lub koob tshuaj; qhov loj dua nws yog, ntev li ntawm cov suab thaj txo qis dua yog nyob hauv nruab nrab - kwv yees li 4 teev.

Neej Neeg tshaj 25

Txhawm rau kom ntsuas qhov tseeb ntawm qhov tshwm sim ntawm Humalog, qabzib yuav tsum tau ntsuas tom qab lub sijhawm no, feem ntau qhov no ua tiav ua ntej noj mov tom ntej. Kev ntsuas ua ntej yog xav tau yog xav tias tsam lub qog ntshav qab zib tsawg.

Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm Lub Tsev Kawm ntawm Diabetology - Tatyana Yakovleva

Kuv tau kawm mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.

Kuv maj nrawm nroos los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj los tsim cov tshuaj uas kho cov ntshav qab zib kom tiav. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.

Lwm qhov xov xwm zoo: Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau ua ib txoj kev saws me nyuam los them rau cov nqi tshuaj ntau heev. Hauv Lavxias, neeg mob ntshav qab zib kom txog lub Peb Hlis 2 tuaj yeem tau txais nws - Tsuas yog 147 rubles!

Lub sijhawm luv luv ntawm lub Humalog tsis yog qhov ua tsis zoo, tab sis qhov zoo ntawm cov tshuaj. Ua tsaug rau nws, cov neeg mob ntshav qab zib mellitus tsis tshua muaj kev tiv thaiv ntshav qab zib, tshwj xeeb tshaj yog thaum tsaus ntuj.

Neej Neeg Sib

Ntxiv rau qhov Humalog, lub tuam txhab kev lag luam kws tsim tshuaj Lilly France tsim cov Humalog Mix. Nws yog kev sib xyaw ntawm lyspro insulin thiab protamine sulfate. Ua tsaug rau qhov kev sib txuam no, lub sijhawm pib ntawm cov tshuaj hormone tseem zoo li qub, thiab lub sijhawm ua haujlwm tau nce ntxiv.

Humalog Mix yog muaj nyob rau hauv 2 ntau qhov:

Qhov zoo dua ntawm cov tshuaj no yog cov tshuaj txhaj yooj yim dua. Kev tiv thaiv kab mob ntshav qab zib mellitus thaum lawv siv yog qhov phem dua li nrog kev kho mob ntxiv ntawm kev siv tshuaj insulin thiab kev siv Humalog li ib txwm, yog li ntawd, rau cov me nyuam Humalog Mix tsis siv .

Qhov tshuaj insulin no tau sau tseg:

1. Cov neeg mob ntshav qab zib uas tsis tuaj yeem xam tus kheej ntawm koob tshuaj lossis ua ib qho kev txhaj tshuaj, piv txwv, vim tsis pom kev tsis zoo, tuag tes tuag taw lossis tshee.
2. Cov neeg mob mob hlwb.
3. Cov neeg laus uas muaj ntau yam mob ntshav qab zib thiab kev paub tsis zoo txog kev kho yog tias lawv tsis kam kawm.
4. Tus neeg mob ntshav qab zib nrog hom 2 yog tias nws tus kheej tawm los tsim.

Kev kho mob ntshav qab zib nrog Humalog Mix yuav tsum noj zaub mov kom nruj, yuav tsum noj khoom txom ncauj thaum noj mov. Nws raug tso cai noj 3 XE rau noj tshais, txog 4 XE rau noj su thiab noj hmo, txog 2 XE rau noj hmo, thiab 4 XE ua ntej yuav mus pw.

Cov Kev Tshaj Tawm ntawm Humalog

Lyspro insulin raws li cov tshuaj nquag muaj tsuas yog nyob hauv thawj phau ntawv teev npe. Cov tshuaj uas ze ze yog (raws li aspart) thiab (glulisin). Cov cuab yeej no tseem yog ultra-luv, yog li nws tsis muaj teeb meem twg uas yuav tsum xaiv. Txhua tus tau txais txiaj ntsig zoo thiab muab cov suab thaj txo ntau.Raws li txoj cai, kev nyiam yog muab rau cov tshuaj, uas tuaj yeem muab pub dawb hauv chaw kho mob.

Qhov kev hloov pauv ntawm Humalog mus rau nws txoj kab ke paum yuav tau tsim nyog muaj kev fab ua txhaum. Yog tias tus mob ntshav qab zib ua raws li cov zaub mov uas tsis muaj carb ntau, lossis feem ntau muaj ntshav qab zib hauv lub cev, nws yog qhov muaj kuab siv tib neeg ntau dua li siv cov tshuaj insulin.

Nco ntsoov kawm! Koj puas xav tias kev tswj hwm kev noj qab haus huv ntawm cov tshuaj thiab cov kua dej yog ib txoj kev los tswj cov piam thaj kom tswj? Tsis muaj tseeb! Koj tuaj yeem soj ntsuam qhov no koj tus kheej los ntawm kev pib siv nws.

DNA recombinant tib neeg cov tshuaj insulin.
Npaj: HUMALOG®
Cov tshuaj nquag ntawm cov tshuaj: tshuaj insulin lyspro
ATX Encoding: A10AB04
KFG: Ua yeeb yam rau neeg lub cev tsis txaus siab
Npe sau npe: P No. 015490/01
Hnub sau npe: 02.02.04
Tswv reg reg. acc .: LAGY FRANCE S.A.S.

Kev daws rau kev txhaj tshuaj yog pob tshab, tsis muaj kob.

1 ml
tshuaj insulin lispro *
100 IU

Cov kev zam: glycerol, zinc oxide, sodium hydrogen phosphate, m-cresol, dej d / thiab, hydrochloric acid daws ntawm 10% thiab sodium hydroxide tov ntawm 10% (los tsim kom muaj qib pH uas yuav tsum tau).

3 ml - cartridges (5) - hlwv (1) - pob khoom los ntawm cardboard.

* Lub npe tsis yog thoob ntiaj teb uas pom zoo los ntawm WHO, hauv Lavxias teb sab lus, sau tus npe ntawm lub npe thoob ntiaj teb - insulin lispro raug lees txais.

Cov lus piav qhia ntawm cov tshuaj yog ua raws cov lus qhia raug pom zoo rau kev siv.

Pharmacological ua Humalog

DNA recombinant tib neeg cov tshuaj insulin. Nws txawv ntawm qhov kawg hauv kev rov ua dua ntawm cov amino acids ntawm txoj haujlwm 28 thiab 29 ntawm cov kab hluav taws xob insulin B.

Lub txiaj ntsig tseem ceeb ntawm cov tshuaj yog kev tswj hwm ntawm cov metabolism hauv qab ntuj. Tsis tas li ntawd, nws muaj qhov ua kom anabolic. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Hauv cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib mellitus, thaum siv cov tshuaj insulin lyspro, hyperglycemia uas tshwm sim tom qab noj mov tau nce ntau dua piv rau kev tiv thaiv tib neeg cov kua dej. Rau cov neeg mob tau txais cov tshuaj insulins luv luv thiab hauv paus, nws yog ib qho tsim nyog yuav tsum xaiv cov koob tshuaj ntawm ob qho insulins thiaj li ua tiav cov ntshav qabzib kom zoo thoob plaws ib hnub.

Ib yam li txhua qhov kev npaj tshuaj insulin, lub sijhawm lyspro insulin ua haujlwm tuaj yeem sib txawv hauv cov neeg mob lossis sijhawm sib txawv ntawm tib tus neeg mob thiab nyob ntawm lub koob tshuaj, chaw txhaj tshuaj, ntshav ntshav, kub cev thiab kev tawm dag zog.

Cov yam ntxwv ntawm lyspro insulin hauv cov menyuam yaus thiab cov hluas yog cov zoo sib xws ntawm cov neeg laus saib.

Hauv cov neeg mob uas muaj ntshav qab zib hom 2 tau txais cov tshuaj sulfonylurea ntau tshaj plaws, qhov ntxiv ntawm lyspro insulin ua rau txo qis glycosylated hemoglobin.

Lyspro insulin kho nyob rau hauv cov neeg mob uas muaj hom 1 thiab ntshav qab zib hom 2 yog nrog nws cov neeg tsawg zuj zus mus ntawm nocturnal hypoglycemia.

Qhov glucodynamic lo lus teb rau isulin lispro tsis vam khom rau kev ua haujlwm tsis zoo ntawm lub raum lossis nplooj siab.

Lyspro insulin tau pom tias yog ua kom sib luag rau tib neeg cov tshuaj insulin, tab sis nws cov kev ua tshwm sim sai dua thiab kav rau lub sijhawm luv.

Lyspro insulin yog tus cwj pwm los ntawm qhov pib sai ntawm kev coj ua (li 15 feeb), raws li Nws muaj qhov nqus dej siab, thiab qhov no tso cai rau koj nkag mus rau nws tam sim ntawd ua ntej noj mov (0-15 feeb ua ntej noj mov), hauv kev sib piv rau cov pa luv luv ua yeeb yam (30-45 feeb ua ntej noj mov). Lyspro insulin muaj lub sijhawm luv dua (2 mus rau 5 teev) piv rau tib neeg cov tshuaj insulin.

Pharmacokinetics ntawm cov tshuaj.

Xuas thiab faib khoom

Tom qab cov tswj hwm sc, insulin Lyspro nrawm nrawm thiab mus txog Cmax hauv ntshav ntshav tom qab 30-70 feeb. Vd ntawm insulin lyspro thiab insulin tib neeg zoo ib yam thiab muaj nyob ntawm thaj tsam ntawm 0.26-0.36 l / kg.

Nrog sc tswj kev tswj hwm ntawm T1 / 2 ntawm insulin, lyspro yog li 1 teev. Cov neeg mob raum thiab mob hepatic tsis txaus muaj qhov feem ntau ntawm kev nqus ntawm lyspro insulin piv rau cov tshuaj insulin rau tib neeg.

Dosage thiab txoj hauv kev ntawm kev tswj hwm tshuaj.

Tus kws kho mob txiav txim siab muab koob tshuaj ib leeg zuj zus, nyob ntawm qhov xav tau ntawm tus neeg mob. Cov tshuaj Humalog tuaj yeem muab sai ua ntej noj mov, yog tias tsim nyog - sai sai tom qab noj mov.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov.

Qhov tshuaj Humalog yog muab sc rau hauv txoj kev txhaj tshuaj lossis hauv daim ntawv ntawm ncua ntev inf infusion siv lub twj tso kua mis. Yog tias tsim nyog (ketoacidosis, mob hnyav, lub sijhawm ntawm kev ua haujlwm lossis sijhawm hla sijhawm) Humalog tuaj yeem nkag mus rau hauv / hauv.

SC yuav tsum muab rau lub xub pwg, ncej puab, pob tw, lossis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj 1 zaug hauv ib hlis. Thaum s / qhia txog cov tshuaj Humalog, yuav tsum saib xyuas kom tsis txhob txais cov tshuaj rau hauv cov hlab ntsha. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws. Tus neeg mob yuav tsum tau kawm siv cov txheej txheem kev txhaj tshuaj kom raug.

Cov kev cai rau kev tswj hwm ntawm cov tshuaj Humalog

Npaj rau kev qhia

Kev daws ntawm cov tshuaj Humalog yuav tsum yog pob tshab thiab xim tsis muaj xim. Ib qho huab, tuab lossis xim me ntsis ntawm cov tshuaj, lossis yog tias cov khoom tawg tau pom los rau hauv nws, yuav tsum tsis txhob siv.

Thaum txhim kho lub taub ntim hauv cov koob txhaj tshuaj (tus cwj mem-txhaj), txuas lub koob thiab coj kev txhaj tshuaj insulin, nws yog qhov yuav tsum tau ua raws li cov khw muag cov lus qhia uas txuas nrog txhua tus xaum xim.

2. Xaiv lub xaib rau kev txhaj tshuaj.

3. Tshuaj tua kab mob los kho cov tawv nqaij ntawm qhov chaw txhaj tshuaj.

4. Tshem tawm lub hau ntawm rab koob.

5. Kho cov tawv nqaij los ntawm kev ncab nws lossis los ntawm kev ruaj ntseg ntawm cov quav loj. Ntxig lub koob txhaj tshuaj raws li cov lus qhia siv kev xaum xim.

6. Nias lub pob ntawd.

7. Tshem tawm rab koob thiab maj mam nyem qhov chaw txhaj tshuaj rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.

8. Kev siv rab koob rab koob, tshem tawm rab koob thiab rhuav tshem nws.

9. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom qhov chaw qub siv tsis ntau tshaj li 1 zaug hauv ib hlis.

Kev tswj hwm ntawm insulin

Kev txhaj tshuaj tiv thaiv ntawm Humalog yuav tsum tau nqa tawm raws li kev siv tshuaj txhaj rau txoj kev txhaj tshuaj, piv txwv, txhaj tshuaj bolus tswj lossis siv cov txheej txheem infusion. Hauv qhov no, nws yog ib qho tsim nyog feem ntau los tswj cov qib ntawm cov piam thaj hauv cov ntshav.

Lub tshuab ua ke nrog cov ntsiab lus los ntawm 0.1 IU / ml txog rau 1.0 IU / ml insulin lispro hauv 0.9% sodium chloride tov lossis 5% dextrose daws yog ruaj khov nyob rau hauv chav tsev rau 48 teev.

P / C insulin infusion siv lub twj tso kua mis

Rau kev ua txhaum ntawm cov tshuaj Humalog, Minimed thiab Disetronic cov twj tso kua mis tuaj yeem siv rau cov tshuaj insulin. Koj yuav tsum nruj me ntsis ua raws cov lus qhia uas tuaj nrog lub twj tso kua mis. Txoj kev lis ntshav yog hloov pauv txhua 48 teev .Thaum txuas lub infusion system, kev cai aseptic tau pom. Thaum muaj qhov qog ntawm hypoglycemic, Txoj kev lis ntshav yog nres kom txog rau thaum rov zoo. Yog tias pheej rov qab lossis qis dua cov piam thaj hauv cov ntshav tau sau tseg, tom qab ntawd nws yog qhov yuav tsum tau qhia rau tus kws kho mob txog qhov no thiab txiav txim siab txo lossis tso tseg qhov insulin infusion. Lub twj tso kua mis tsis ua hauj lwm lossis kev txhaws hauv txoj kev lis ntshav tuaj yeem ua rau nce ntxiv hauv cov piam thaj. Yog tias lub sijhawm ua txhaum cai ntawm kev ua txhaum ntawm kev muab cov tshuaj insulin, koj yuav tsum ua raws li cov lus qhia thiab yog tias tsim nyog, qhia rau tus kws kho mob. Thaum siv lub twj tso kua mis, cov tshuaj Humalog yuav tsum tsis txhob muab sib xyaw nrog lwm cov tshuaj insulins.

Sab nyhuv Humalog:

Kev phiv cuam tshuam nrog cov nyhuv tseem ceeb ntawm cov tshuaj: hypoglycemia. Kev mob ntshav khov ntau heev tuaj yeem ua rau tsis nco qab (hypoglycemic coma) thiab, tshwj tsis yog rau kev tuag.

Kev tsis haum tshuaj: kev tawm tsam ntawm lub cev muaj peev xwm ua tau - liab liab, o lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau ploj hauv ob peb hnub lossis ob peb asthiv), kev tiv thaiv kev tsis haum tshuaj (feem ntau tsis tshua muaj, tab sis muaj dua loj dua) - ua kom khaus, ua pob khaus, mob hlwb, mob taub hau, ua npaws, ua tsis taus pa, txo cov ntshav siab, tachycardia, tawm hws. Cov uas muaj mob hnyav raug neeg lub cev tuaj yeem tas sim neej.

Lwm yam: lipodystrophy ntawm qhov chaw txhaj tshuaj.

Siv thaum cev xeeb tub thiab lactation.

Txog rau hnub no, tsis muaj qhov xav tau ntawm Lyspro insulin rau kev xeeb tub lossis kev noj qab haus huv ntawm tus menyuam / tus menyuam tshiab tau pom. Tsis muaj cov kev tshawb fawb nthuav txog kab mob sib kis.

Lub hom phiaj ntawm insulin txoj kev kho mob thaum cev xeeb tub yog tswj hwm cov ntshav qabzib kom txaus rau cov neeg mob ntshav qab zib insulin-los yog mob ntshav qab zib hauv lub ntsej muag. Qhov xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb thaum cev xeeb tub. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov poj niam ntawm lub hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov pib lossis npaj kom cev xeeb tub. Thaum cev xeeb tub, cov neeg mob ntshav qab zib yuav tsum ua tib zoo saib xyuas cov ntshav qabzib, nrog rau kev saib xyuas neeg mob txhua yam.

Hauv cov neeg mob uas mob ntshav qab zib mellitus thaum pub niam mis, yuav tsum tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum.

Cov lus qhia tshwj xeeb rau kev siv Humalog.

Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis hom tshuaj insulin yuav tsum tau ua raws li kev saib xyuas mob nkeeg nruj me ntsis. Cov kev hloov hauv kev ua, hom (tsim tawm), hom (piv txwv, tsis tu ncua, NPH, Daim kab xev), hom (tsiaj, tib neeg, tib neeg insulin analogue) thiab / lossis cov qauv kev tsim tawm (DNA recombinant insulin lossis insulin ntawm keeb kwm tsiaj) yuav xav tau hloov pauv cov koob tshuaj.

Kev mob uas cov cim qhia ntxov ntawm hypoglycemia yog qhov tsis tseem ceeb thiab tsis tshua hais tawm muaj xws li txuas ntxiv cov ntshav qab zib mellitus, kev kho mob insulin ntau ntxiv, kab mob hauv cov kab mob ntshav qab zib mellitus, lossis tshuaj noj, xws li beta-blockers.

Hauv cov neeg mob hypoglycemic tshua tom qab hloov los ntawm tsiaj los ntawm cov tshuaj insulin rau tib neeg insulin, cov tsos mob thaum ntxov ntawm hypoglycemia yuav tsis tshua pom los yog txawv ntawm cov kev paub dhau los ntawm lawv cov insulin yav dhau los. Kev tswj tsis tau tus mob hypoglycemic lossis hyperglycemic tshua tuaj yeem ua rau tsis nco qab, tsis nco qab, lossis tuag.

Kev noj tshuaj tsis txaus lossis tsis ua haujlwm ntawm kev kho mob, tshwj xeeb tshaj yog muaj cov kab mob ntshav qab zib insulin-tuaj yeem ua rau hyperglycemia thiab ntshav qab zib ketoacidosis, cov xwm txheej uas yuav tsim kev phom sij rau tus neeg mob.

Txoj kev xav tau cov tshuaj insulin tuaj yeem txo cov neeg mob lub raum tsis ua haujlwm, zoo ib yam li cov neeg mob lub siab ua haujlwm vim qhov ua haujlwm tsawg kawg ntawm gluconeogenesis thiab insulin metabolism. Txawm li cas los xij, nyob rau hauv cov neeg mob mob siab tsis ua haujlwm ntev, muaj peev xwm tiv thaiv insulin ntau dua tuaj yeem ua rau muaj kev nce ntxiv hauv insulin.

Qhov xav tau ntawm cov tshuaj insulin tuaj yeem nce nrog cov kis kab mob, kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov carbohydrates hauv cov zaub mov noj.

Yog hais tias tus neeg mob lub cev qoj ib ce ntau zog los yog pauv noj zaub mov zoo ces kuj tseem yuav tsum tau txhaj koob tshuaj. Kev tawm dag zog tam sim ntawd tom qab noj mov tas yuav ua rau muaj ntshav qab zib tsawg dua.Ib qhov tshwm sim ntawm lub pharmacodynamics ntawm kev ua yeeb yam sai sai ntawm insulin analogues yog tias yog tias cov ntshav qog ntshav qab zib, tom qab ntawd nws tuaj yeem txhim kho tom qab txhaj tshuaj dua li thaum txhaj cov tshuaj tiv thaiv tib neeg cov tshuaj insulin.

Tus neeg mob yuav tsum tau ceeb toom tias yog tias tus kws kho mob tau sau ib qho tshuaj insulin nrog rau 40 IU / ml hauv lub vial, ces cov tshuaj insulin yuav tsum tsis txhob los ntawm daim cartridge nrog cov tshuaj insulin ntawm 100 IU / ml nrog koob txhaj rau kev txhaj tshuaj insulin nrog qhov sib luag ntawm 40 IU / ml.

Yog tias nws yuav tsum tau noj lwm cov tshuaj tib lub sijhawm uas Humalog, tus neeg mob yuav tsum sab laj nrog kws kho mob.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Nrog hypoglycemia lossis hyperglycemia cuam tshuam nrog kev noj tshuaj tsis zoo, kev ua txhaum ntawm kev muaj peev xwm mloog zoo thiab qhov ceev ntawm psychomotor cov tshuaj tiv thaiv tuaj yeem tau. Qhov no tuaj yeem dhau los ua kev pheej hmoo rau cov haujlwm muaj kev phom sij (suav nrog kev tsav tsheb lossis kev ua haujlwm nrog cov tshuab).

Cov neeg mob yuav tsum tau ceev faj kom tsis txhob muaj hypolycemia thaum tsav tsheb. Qhov no tseem ceeb tshwj xeeb tshaj yog rau cov neeg mob uas muaj qhov txo qis los yog tsis hnov ​​qhov zoo ntawm cov tsos mob ua ntej rau tus mob ntshav qab zib tsawg, los yog leej twg muaj qee yam cov ntshav qog ntshav qis. Hauv cov xwm txheej no, nws yog qhov yuav tsum tau los ntsuas qhov ua tau ntawm kev tsav tsheb. Cov neeg mob ntshav qab zib muaj peev xwm tiv thaiv nws tus kheej los ntawm kev muaj ntshav qabzib tsawg tsawg los ntawm kev noj ntshav qabzib lossis zaub mov ntau hauv carbohydrates (Nws raug nquahu kom koj ib txwm muaj tsawg kawg 20 g piam thaj nrog koj). Tus neeg mob yuav tsum qhia tus kws kho mob uas koom nrog paub txog qhov hloov pauv hypoglycemia.

Humalog sib cuam tshuam nrog lwm yam tshuaj.

Cov nyhuv hypoglycemic yog txo los ntawm kev tiv thaiv qhov ncauj, corticosteroids, thyroid hormone npaj, danazol, beta2-adrenergic agonists (suav nrog rhytodrin, salbutamol, terbutaline), tricyclic antidepressants, thiazide diuretics, chlorprotixenic acid, niacin, diazid derivatives ntawm phenothiazine.

Cov nyhuv hypoglycemic ntawm Humalog yog txhim kho los ntawm beta-blockers, ethanol thiab ethanol-muaj cov tshuaj, anabolic steroids, fenfluramine, guanethidine, tetracyclines, tshuaj tiv thaiv hypoglycemic, salicylates (piv txwv li, acetylsalicylic acid, aniloprilactyl antagonists, MAP inhibitors, Ml. angiotensin II cov neeg txais.

Cov tshuaj tiv thaiv yuav tsum tsis txhob xyaw nrog tsiaj cov tshuaj insulin.

Siv tau cov tshuaj Humalog (nyob rau hauv kev saib xyuas ntawm tus kws kho mob) ua ke nrog kev ua haujlwm ntev ntawm tib neeg cov kua dej los yog ua ke nrog cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, sulfonylurea derivatives.

Cov lus pom zoo cia ntawm cov tshuaj Humalog.

Sau npe B. Cov tshuaj yuav tsum muab cia kom ncav tsis cuag ntawm cov menyuam yaus, hauv lub tub yees, ntawm qhov txias li 2 ° txog 8 ° C, tsis txhob cia kom khov. Txee lub neej yog 2 xyoos.

Cov tshuaj yeeb hauv kev siv yuav tsum khaws cia hauv chav sov li ntawm 15 ° txog 25 ° C, tiv thaiv los ntawm tshav ntuj ncaj qha thiab kub. Txee lub neej - tsis pub dhau 28 hnub.

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb Neej Neeg Cov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Humalog hauv lawv cov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov Txiaj Ntsig ntawm Humalog nyob rau hauv muaj cov qauv txheej txheem qauv. Siv rau kev kho mob ntawm hom 1 thiab hom 2 mob ntshav qab zib mellitus (ntshav qab zib-insulin thiab tsis-insulin-mob ntshav qab zib) rau cov neeg laus, menyuam, nrog rau lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Neej Neeg - cov duab ntawm cov tshuaj insulin, txawv ntawm nws los ntawm kev rov qab ua ntu zus ntawm cov kab sib luag thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Piv nrog luv luv ua yeeb yam npaj cov tshuaj insulin, lyspro insulin yog tus yam ntxwv sai dua ntawm qhov pib thiab qhov kawg ntawm cov nyhuv, uas yog vim muaj kev nqus ntxiv los ntawm subcutaneous depot vim yog kev txuag ntawm monomeric qauv ntawm lyspro insulin lwg me me hauv cov tshuaj. Qhov pib ntawm kev ua yog 15 feeb tom qab tswj hwm subcutaneous, qhov ua haujlwm siab tshaj plaws yog nruab nrab ntawm 0.5 teev thiab 2.5 teev, lub sijhawm ua ntawm 3-4 teev.

Humalog Mix yog DNA - muab cov kab mob tshiab ntawm tib neeg cov kua dej thiab yog qhov sib xyaw ua ke uas muaj lyspro insulin tov (kev ua kom sai ntawm tib neeg cov kua dej) thiab kev ncua ntawm lyspro protamine insulin (nruab nrab ntev tib neeg cov tshuaj insulin).

Kev ua tseem ceeb ntawm insulin lyspro yog kev cai ntawm cov metabolism hauv cov piam thaj. Ntxiv rau, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Lyspro insulin + excipients.

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), qhov koob tshuaj (ntim ntawm txhaj tshuaj insulin), thiab qhov tob ntawm cov tshuaj insulin hauv kev npaj. Nws tau faib tawm tsis ncaj hauv daim ntaub. Nws tsis hla tus cwj pwm ntawm lub tso mis thiab nkag rau hauv niam mis. Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum - 30-80%.

• yam 1 mob ntshav qab zib mellitus (insulin-dependant), suav nrog nrog kev tsis nkag siab rau lwm txoj kev npaj tshuaj insulin, nrog postprandial hyperglycemia uas tsis tuaj yeem kho los ntawm lwm yam kev npaj tshuaj insulin, mob subcutaneous insulin tsis kam (nrawm hauv lub zos insulin degradation),
• hom 2 mob ntshav qab zib mellitus (non-insulin-dependant): nrog kev tawm tsam cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, nrog rau kev nqus tsis tau ntawm lwm yam tshuaj insulin, kev tiv thaiv tsis tau tom qab hyperglycemia, thaum lub sijhawm ua haujlwm, cov kabmob sib kis.

Ib qho kev daws teeb meem rau kev tswj hwm kom haum thiab subcutaneous ntawm 100 IU hauv 3 ml cartridge sib xyaw rau hauv QuickPen cwj mem los yog cwj mem kua txho.

Ncua rau kev rho tawm ntawm 100 IU hauv 3 ml cartridge sib xyaw rau hauv QuickPen cwj mem los yog cwj mem kua (Humalog Mix 25 thiab 50).

Lwm cov ntaub ntawv ntau npaum li cas, tsis pub muaj ntsiav tshuaj lossis tsiav tshuaj, tsis muaj nyob.

Cov lus qhia rau kev siv thiab qauv ntawm kev siv

Dosage yog teeb tsa ib tus zuj zus. Lyspro insulin yog muab tshuaj subcutaneously, intramuscularly lossis intravenously 5-15 feeb ua ntej noj mov. Ib koob tshuaj yog 40 units, ntau dhau tsuas tso cai tshwj xeeb. Nrog rau cov tshuaj tua kab mob, Lyspro insulin muab rau 4-6 zaug hauv ib hnub, ua ke nrog kev npaj tshuaj insulin ntev - 3 zaug hauv ib hnub.

Cov tshuaj yuav tsum tau muab tshuaj subcutaneously.

Tso dej siab tswj hwm ntawm cov tshuaj Humalog Mix yog contraindicated.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov.

Subcutaneously yuav tsum txhaj rau hauv lub xub pwg, ncej puab, pob tw los sis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj 1 zaug hauv ib hlis. Thaum s / qhia txog cov tshuaj Humalog, yuav tsum saib xyuas kom tsis txhob txais cov tshuaj rau hauv cov hlab ntsha. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.

Thaum txhim kho lub taub hau hauv lub twj txhaj tshuaj insulin thiab txuas lub koob ua ntej insulin thawj coj, cov lus qhia ntawm cov chaw tsim khoom ntawm cov cuab yeej siv tshuaj insulin yuav tsum ua raws cai.

Cov kev cai rau kev qhia ntawm cov tshuaj Humalog Mix

Npaj rau kev qhia

Tam sim ntawd ua ntej siv, Humalog Mix sib xyaw cartridge yuav tsum tau muab sib dhos ntawm xib teg kaum npaug thiab tshee, tig ntawm 180 ° kuj kaum zaus kom rov kho cov tshuaj insulin kom txog thaum nws zoo li homogeneous huab lossis kua mis. Tsis txhob co khov kho, raws li qhov no tuaj yeem ua rau npuas dej, uas tuaj yeem cuam tshuam nrog cov koob tshuaj kom raug. Txhawm rau kom yooj yim rau kev sib xyaw, lub pob txha taub ntawv muaj lub khob iav me me. Cov tshuaj yuav tsum tsis txhob siv yog tias nws muaj plaub yaig tom qab tov.

Yuav siv cov tshuaj li cas

1. Ntxuav tes.
2. Xaiv ib qho chaw rau kev txhaj tshuaj.
3. Kho cov tawv nqaij nrog tshuaj tua kab mob ntawm qhov chaw txhaj tshuaj (nrog rau kev coj tus kheej, raws li tus kws kho mob cov lus pom zoo).
4. Tshem lub hau tiv thaiv sab nraud ntawm rab koob.
5. Txhim kho cov tawv nqaij los ntawm rub nws los yog khi cov quav loj.
6. Ntxig lub koob txhaj tshuaj subcutaneously thiab ua qhov kev txhaj tshuaj raws li cov lus qhia siv kev siv tus xaum xim.
7. Tshem tawm rab koob thiab maj mam muab nyem qhov chaw txhaj tshuaj rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.
8. Siv lub hau sab tiv thaiv ntawm rab koob, unscrew lub koob thiab rhuav tshem nws.
9. Tso lub hau rau ntawm tus cwj mem xaum qhuav.

• hypoglycemia (mob ntshav qab zib heev tuaj yeem ua rau tsis nco qab thiab, tshwj tsis yog mob tuag,),
• liab, o, lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau ploj hauv ob peb hnub lossis limtiam, qee qhov xwm txheej no tuaj yeem yog vim los ntawm tsis muaj feem cuam tshuam nrog insulin, piv txwv li, voos tawv nqaij los ntawm kev siv tshuaj tua kab mob los yog kev txhaj tshuaj tsis zoo),
• dav khaus
• ua pa nyuaj
• txog siav
• txo hauv cov ntshav siab,
• tachycardia
• nce hws
• kev txhim kho ntawm lipodystrophy ntawm thaj chaw txhaj tshuaj.

• ntshav qab zib,
• ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Txog hnub, tsis muaj qhov xav tau ntawm Lyspro insulin rau kev xeeb tub lossis qhov xwm txheej ntawm tus menyuam hauv plab thiab cov menyuam tshiab tau pom.

Lub hom phiaj ntawm kev kho tshuaj insulin thaum cev xeeb tub yog kom tswj tau cov piam thaj kom txaus. Qhov xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb thaum cev xeeb tub. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov poj niam ntawm lub hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov pib lossis npaj kom cev xeeb tub.

Hauv cov neeg mob uas mob ntshav qab zib mellitus thaum pub niam mis, yuav tsum tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum.

Cov kab ke ntawm cov thawj coj npaj rau kev siv ntau npaum ntawm lyspro insulin yuav tsum nruj me ntsis. Thaum hloov cov neeg mob los ntawm kev ua yeeb yam sai sai insulin npaj cov tsiaj keeb kwm rau insulin lispro, yuav tsum tau txhaj koob tshuaj. Kev hloov chaw ntawm cov neeg mob tau txais cov tshuaj insulin nyob rau hauv ib hnub ntau dua 100 units los ntawm ib hom tshuaj insulin mus rau lwm qhov tau pom zoo kom nqa tawm hauv tsev kho mob.

Kev xav tau rau cov tshuaj insulin tuaj yeem nce ntxiv thaum kis kab mob, nrog kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov khoom noj carbohydrates hauv cov zaub mov, thaum ntxiv kev noj tshuaj ntxiv nrog hyperglycemic kev ua si (cov thyroid hormones, glucocorticoids, qhov ncauj tiv thaiv, thiazide diuretics).

Qhov xav tau ntawm cov tshuaj insulin yuav txo qis nrog lub raum thiab / lossis lub siab ua haujlwm, nrog qhov kev txiav txim siab ntawm cov khoom noj carbohydrates hauv zaub mov, nrog kev tawm dag zog lub cev, thaum ntxiv kev noj tshuaj nrog hypoglycemic kev ua si (MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides).

Kev kho cov ntshav qog ntshav qab zib hauv qhov mob hnyav tuaj yeem nqa tawm los ntawm kev siv i / m thiab / lossis s / c tswj hwm ntawm glucagon lossis iv kev tswj xyuas ntshav qabzib.

Cov nyhuv hypoglycemic ntawm Lyspro insulin yog txhim kho los ntawm MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides, acarbose, ethanol (cawv) thiab tshuaj uas muaj ethanol.

Cov nyhuv hypoglycemic ntawm Lyspro insulin yog txo los ntawm glucocorticosteroids (GCS), cov thyroid hormones, tshuaj tiv thaiv qhov ncauj, thiazide diuretics, diazoxide, tricyclic antidepressants.

Beta-blockers, clonidine, reserpine tuaj yeem npog qhov tsos ntawm cov tsos mob ntawm qog ntshav qab zib.

Cov tshuaj ntawm cov tshuaj Humalog

Cov qauv ntawm cov qauv ua haujlwm:

• Lyspro insulin
• Humalog Mix 25,
• Neej Neeg Qhia 50.

Cov cim qhia hauv pawg pharmacological (insulins):

• Tus kws kho mob HM Penfill,
• Actrapid MS,
• B-Insulin S.Ts. Berlin Chemie,
• Berlinsulin H 30/70 U-40,
• Berlinsulin H 30/70 cwj mem,
• Berlinsulin N Basal U-40,
• Berlinsulin N Basal Cwj mem,
• Berlinsulin Hom U-40,
• Berlinsulin N Tus Cwj Pwm Zoo Li Cas,
• Qov tshuaj insulin C,
• Isofan Insulin Ntiaj Teb Khob,
• Iletin
• Insulin Daim Kab Xev SPP,
• Tshuaj insulin
• Nqaij npuas ua kua txig ntau dhau los ua tiav MK,
• Insuman Zuag,
• Rau Sab Kev SPP,
• Intral Ntiaj Teb Khob,
• Combinsulin C
• Mikstard 30 NM Penfill,
• Monosuinsulin MK,
• Monotard
• Pensulin,
• Protafan HM Penfill,
• Protafan MS,
• Rinsulin
• Ultratard NM,
• Homolong 40,
• Hom 40,
• Neeg lim hiam.

Thaum tsis muaj cov tshuaj analogues rau cov tshuaj rau cov tshuaj yeeb dej caw, koj tuaj yeem nyem rau ntawm qhov txuas hauv qab no rau cov kab mob uas cov tshuaj tsim nyog pab los ntawm thiab pom muaj cov analogues rau kev kho mob nyhuv.

Cov Tshuaj Hauv Tshuaj

Lyspro insulin yog ib hom tshuaj hypoglycemic uas yog koom nrog pab pawg ntawm cov yeeb yam luv luv insulins. Nws cov tshuaj ua haujlwm yog insulin lispro, cov lus sib piv ntawm deoxyribonucleic acid (DNA) ntawm tib neeg insulin, uas nws txawv ntawm nws los ntawm kev kho dua tshiab ntawm cov amino acids ntawm txoj haujlwm 28 thiab 29 hauv B txoj hlua ntawm insulin molecule.

Ntxiv nrog rau kev tswj kev ua kom ntshav qabzib, insulin lyspro muaj cov teebmeem anabolic thiab anti-catabolic rau cov nqaij hauv lub cev. Hauv cov leeg nqaij, nws ua rau muaj kev nce ntxiv hauv cov ntsiab lus ntawm glycogen, glycerol thiab fatty acids, kev nce ntxiv ntawm kev noj ntawm cov amino acids, thiab nce ntxiv ntawm cov protein synthesis. Nyob rau tib lub sijhawm, muaj kev txwv tsis pub cov txheej txheem ntawm glycogenolysis, ketogenesis, gluconeogenesis, lipolysis, kev tso tawm ntawm cov amino acids, thiab protein catabolism.

Lyspro insulin thiab insulin cov tib neeg yog qhov sib luag, tab sis cov qub qub tau pom los ntawm kev pib sai dua thiab lub sijhawm luv dua ntawm kev ua. Vim lub siab nqus ntawm cov ntshav, qhov ua kom tau qhov qog hypoglycemic ntawm Lyspro insulin tshwm li 1/4 h tom qab kev tswj hwm, uas tso cai rau cov tshuaj siv tam sim ntawd ua ntej noj mov.

Lub sijhawm ntawm cov tshuaj yog los ntawm 2 mus rau 5 teev. Nws tuaj yeem sib txawv ob leeg hauv cov neeg mob sib txawv thiab hauv ib tus neeg mob hauv lub sijhawm sib txawv. Cov kev hloov pauv hauv lub sijhawm tau ua los ntawm koob tshuaj, thaj chaw txhaj tshuaj, ntsuas kub ntawm lub cev, muab ntshav thiab ua haujlwm ntawm tus neeg mob.

Piv nrog soluble tib neeg cov tshuaj insulin, kev siv lyspro insulin tuaj yeem txo qis ntawm ntu ntawm nocturnal hypoglycemia, ntau qhov tseem ceeb txo cov hyperglycemia uas tshwm sim hauv cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib tom qab noj mov.

Hauv cov laus, cov menyuam yaus thiab cov hluas, cov khw muag tshuaj zoo sib xws ntawm cov tshuaj insulin lyspro tau pom.

Qhov glucodynamic teb rau insulin lispro tsis yog nyob ntawm lub xeev ntawm tus neeg mob lub raum lossis lub siab ua haujlwm.

Kev ntsuas rau siv

Kev siv Insulin Lyspro yog qhia txog kev kho mob ntshav qab zib hauv qab no rau cov neeg laus thiab menyuam yaus:

• insulin-tiv thaiv (hom 1 mob ntshav qab zib mellitus): suav nrog cov neeg mob tsis haum rau lwm yam tshuaj insulin, nrog rau kev txhim kho lwm yam tshuaj uas tsis tuaj yeem kho los ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib (tom qab noj) hyperglycemia, mob subcutaneous insulin tsis kam (nrawm hauv insulin hauv zos),
• non-insulin-dependant (hom 2 mob ntshav qab zib mellitus): nyob rau hauv kev tiv thaiv ntawm kev tiv thaiv kab mob rau lub qhov ncauj hypoglycemic, zoo li lub cev tsis haum ntawm lwm yam tshuaj insulin, thaum lub sijhawm phais mob, intercurrent kab mob, tsis tuaj yeem postprandial hyperglycemia.

Lyspro insulin, cov lus qhia rau kev siv: hom thiab ntau npaum li cas

Kev daws ntawm Insulin Lyspro tau npaj rau SC thiab iv kev tswj hwm. Kev txhaj tshuaj yog nqa tawm tsis pub dhau 15 feeb ua ntej noj mov lossis tam sim ntawd tom qab noj mov.

Nyob rau hauv daim tawv nqaij, cov tshuaj tuaj yeem muab tshuaj bolus lossis ua rau ntev tuaj txhaj tshuaj uas siv lub tshuab nqus dej.

Hauv cov hlab ntsha, kev tswj hwm ntawm lyspro insulin yog qhia rau ketoacidosis, mob hnyav, ntawm kev ua haujlwm lossis tom qab phais.

Qhov ntsuas kub ntawm cov tshuaj txhaj yuav tsum haum rau chav tsev kub.

Ua ntej kev tswj hwm, cov ntsiab lus ntawm daim cartridge lossis vial yuav tsum tau muab tshuaj ntsuas kom pom kev haum. Cov kua dej yuav tsum meej thiab tsis muaj xim. Yog tias nws hloov tawm ntawm cov huab, tuab, me ntsis xim lossis yog tias muaj cov khoom txawv teb chaws nyob hauv nws - txoj kev daws teeb meem yuav tsum tau muab pov tseg.

Tus kws kho mob txiav txim siab qhov ntau thiab hom ntawm kev coj ntawm Insulin Lyspro ua ib leeg zuj zus, nyob ntawm seb cov ntshav qabzib hauv cov ntshav.

Kev tswjfwm subcutaneous nrog ib tus xaum xaum xoob

S / c Insulin Lyspro tuaj yeem raug txhaj rau hauv cov nqaij mos ntawm lub plab, xub pwg, ncej puab lossis pob tw, zam qhov kev daws teeb meem nkag mus rau cov hlab ntshav. Lub chaw txhaj tshuaj yuav tsum tau hloov chaw tsis tu ncua, zam kev siv ntawm tib qhov chaw ntau zaus ntau tshaj 1 zaug hauv ib hlis. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.

Cartridges yuav tsum tau siv nrog EndoPen Syringe Pens tsim los ntawm Bagging Gangan Technology Co. Ltd ”(Suav Teb), vim tias qhov raug txhaj tshuaj yog tsim tshwj rau cov xaum xaum koob qhia.

Thaum sau daim ntawv yuav tshuaj, tus kws kho mob yuav tsum qhia tus neeg mob txog kev siv tshuaj ntawm kev txhaj tshuaj sc, thiab ua kom ntseeg tau tias tus neeg mob tau txhaj tshuaj nrog insulin thiab muaj peev xwm siv rab koob txhaj tshuaj.

Lub taub ntim yuav tsum muab nruab rau hauv rab koob txhaj tshuaj thiab kev txhaj tshuaj kom nruj raws li cov khw muag cov lus qhia rau kev siv koob txhaj tshuaj.

Cov lus qhia ib qib-ib-qib rau kev tswj hwm ib koob tshuaj ntawm Insulin lispro:

1. Ntxuav tes kom huv.
2. Xaiv ib qho chaw rau kev txhaj tshuaj.
3. Npaj cov tawv nqaij ntawm qhov chaw txhaj tshuaj kom raws li kws kho mob pom zoo.
4. Tshem lub hau tiv thaiv sab nraud ntawm rab koob.
5. Kho cov tawv nqaij.
6. Tso cov koob txhaj tshuaj rau hauv qab daim tawv nqaij, ua qhov kev txhaj tshuaj raws li cov lus qhia kom nqus ntawm xaum qhwv.
7. Tshem tawm rab koob, maj mam nias qhov chaw txhaj tshuaj nrog tus pas nqus dej txhuam rau ob peb feeb, tsis txhob txhuam thaj chaw txhaj tshuaj.
8. Tshem rab koob nrog lub hau sab tiv thaiv thiab pov tseg.
9. Tso lub hau rau ntawm tus cwj mem xaum qhuav.

Kev tswjfwm subcutaneous nrog lub twj tso kua mis

Lub tshuab nqus dej twj tso kua mis tuaj yeem siv nrog tus txheej txheem rau kev ua haujlwm txuas ntxiv subcutaneous ntawm insulin nrog CE kos. Ua ntej txhua qhov kev qhia, nws yog qhov yuav tsum tau soj ntsuam kom haum rau lub twj tso kua mis tshwj xeeb thiab soj ntsuam nruj txhua yam uas xav tau ntawm cov lus qhia rau nws txoj haujlwm. Lub taub dej haum thiab kav raj rau lub twj tso kua mis yuav tsum tau siv; hloov tas li cov khoom siv rau kev tswj hwm insulin. Hauv qhov rov hais txog tus mob lub cev ntshav nce siab, txoj kev siv tshuaj yuav tsum tau txiav tawm mus txog rau thaum rov kho dua. Yog tias koj pom muaj cov kua dej qab zib hauv cov ntshav tsawg kawg, koj yuav tsum mus ntsib kws kho mob tam sim ntawd. Nws yog ib qho tsim nyog yuav tau txiav txim siab txo qhov koob tshuaj lossis txiav cov thawj coj ntawm lyspro insulin.

Kev cuam tshuam ntawm cov khoom ntawm txoj kev daws teeb meem vim kev txhaws ntawm lub tshuab txhaj tshuaj lossis qhov ua haujlwm tsis zoo ntawm lub tshuab nqus dej tuaj yeem ua rau tus neeg mob nce siab ntxiv hauv cov piam thaj. Yog li, ntawm qhov kev lees paub me ntsis ntawm qhov muaj ib qho kev ua txhaum hauv lub system, nws yuav tsum ua raws li cov lus qhia thiab qhia tus kws kho mob yog tias tsim nyog.

Tsis txhob xyaw Insulin Lyspro nrog rau lwm cov insulins thaum siv lub twj tso kua mis.

Kev txhaj tshuaj leeg

Kev tso ntshav insulin tuaj yeem siv bolus lossis drip, nrog los ntawm kev saib xyuas ntshav qabzib ntau heev.

Rau kev lis ntshav, insulin lyspro tuaj yeem yaj nyob hauv kev daws 5% dextrose lossis 0.9% sodium chloride tov.Thaum cov concentration ntawm cov kua dej hauv cov tshuaj infusion yog nyob rau thaj tsam ntawm 0.1-1 IU ib 1 ml, qhov kev npaj daws tau nyob ruaj khov li 48 teev ntawm chav tso cia kub.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Thaum lub sijhawm siv cov Insulin Lyspro thaum tsav tsheb lossis ua haujlwm nrog cov txheej txheem tsis yooj yim, nws yog qhov yuav tsum tau coj mus rau hauv qhov kev txiav txim siab qhov kev ua txhaum ntawm kev ceev ntawm psychomotor cov tshuaj tiv thaiv thiab muaj peev xwm mloog zoo thaum lub sijhawm txhim kho hypo- lossis hyperglycemia vim los ntawm kev noj tshuaj tsis zoo. Kev ceev faj tshwj xeeb yog pom zoo rau cov neeg mob uas muaj kev pheej hmoo ntawm cov ntshav qab zib tsawg, nrog qhov kev txo qis ntawm cov tsos mob ua ntej ntawm cov ntshav tsis tuaj yeem lossis lawv tsis tuaj. Nws yog qhov yuav tsum tau ua qhov kev ntsuas tus kheej ntawm kev tsim nyog ntawm kev tsav tsheb.

Kev txheeb xyuas txog Insulin Lyspro

Ntawm cov chaw tshwj xeeb niaj hnub no tsis muaj kev tshuaj xyuas txog Insulin Lyspro los ntawm cov neeg mob thiab lawv tsev neeg.

Cov kws tshaj lij pom zoo kom siv cov tshuaj subcutaneous, ua yeeb yam sai sai ntawm insulin analogue - insulin lispro, nyob rau ntawm kev mob ntshav qab zib ua rau lub cev tsis zoo los ntawm cov ntshav qab zib tsis tau tswj (mob ntshav qab zib ketoacidosis), es tsis txhob siv cov qauv kho mob (kev tswj hwm sai ntawm kev siv tshuaj insulin). Txij li thaum qhov no nws ua tau nrawm dua li tib neeg kev siv tshuaj insulin thiab zam kev txuas ntxiv iv ntaws tshuaj, uas feem ntau xav tau pw hauv tsev kho mob ntawm tus neeg mob hauv chav saib xyuas mob hnyav.

Tus nqi ntawm insulin lispro hauv cov chaw muag tshuaj

Tus nqi ntawm Insulin Lyspro rau ib pob uas muaj 1 lub ntim nrog ib qho kev daws teeb meem tuaj yeem yog los ntawm 252 rubles, 5 daim cartridges los ntawm 1262 rubles, 1 lub raj mis (10 ml) - los ntawm 841 rubles.

Kev Kawm Ntawv: Thawj Moscow State Medical University muaj npe tom qab I.M. Sechenov, tshwj xeeb "Tshuaj General".

Cov ntaub ntawv hais txog cov tshuaj raug muab dav dav, muab rau kev qhia tawm thiab tsis hloov chaw cov lus qhia. Kev siv tshuaj rau tus kheej yog qhov txaus ntshai rau kev noj qab haus huv!

Thaum lub neej, tus neeg nruab nrab tsim tawm tsis tsawg tshaj li ob lub pas dej loj uas muaj qaub ncaug.

Tus mob uas tsis tshua muaj mob yog Kuru's kab mob. Tsuas yog cov neeg sawv cev ntawm pawg neeg Fore hauv New Guinea mob nrog nws. Tus neeg mob tuag ntawm kev luag. Nws ntseeg tau tias qhov ua rau tus mob yog noj tib neeg lub hlwb.

Hauv kev mob siab kom tau tus neeg mob tawm, cov kws kho mob feem ntau mus deb dhau. Yog li, piv txwv li, qee yam Charles Jensen nyob rau lub sijhawm txij xyoo 1954 txog 1994. muaj sia nyob ntau dua 900 lub neoplasm tshem tawm txoj haujlwm.

Nws tau siv los ua yawning enriches lub cev nrog oxygen. Txawm li cas los xij, lub tswv yim no tau sib kis. Cov kws tshawb fawb tau ua pov thawj tias yawning, ib tus neeg ua kom lub hlwb txias thiab txhim kho kev ua haujlwm.

Txhua tus neeg muaj tsis tsuas yog nyias tus ntiv tes, tab sis kuj hais lus.

Txawm hais tias ib tug neeg lub siab tsis yeej, tam sim no nws tseem tuaj yeem nyob rau lub sijhawm ntev, zoo li tus neeg nuv ntses neeg Norwegian Jan Revsdal tau ua rau peb pom. Nws "lub cev muaj zog" nres rau 4 xuab moos tom qab tus neeg nuv ntses tau ploj thiab tsaug zog hauv cov daus.

Yog tias koj luag nyav tsuas yog ob zaug ib hnub, koj tuaj yeem txo cov ntshav siab thiab txo qhov kev pheej hmoo ntawm lub plawv thiab mob nkees.

Thaum cov neeg nyiam hnia, lawv ib leeg poob 6.4 kcal ib feeb, tab sis tib lub sijhawm lawv sib pauv yuav luag 300 ntau hom kab sib txawv.

Muaj ntau cov kev kho mob nthuav tawm heev, xws li kev siv khoom tsis nco qab ntawm cov khoom. Hauv plab ntawm ib tus neeg mob uas tau mob los ntawm tus txiv neej no, 2500 cov khoom txawv teb chaws tau pom.

Ntau cov tshuaj tau xub pib ua lag luam li tshuaj. Piv txwv li yeeb dawb, tau pib ua lag luam ua tshuaj hnoos. Thiab cocaine tau pom zoo los ntawm cov kws kho mob ua tshuaj loog thiab yog lub zog ntawm kev ua kom lub siab ntev.

Ntau lab tus kab mob tau yug, ciaj thiab tuag hauv peb lub plab. Lawv tuaj yeem pom tsuas yog txhawb nqa siab, tab sis yog tias lawv tuaj ua ke, lawv yuav haum rau hauv lub khob kas fes.

Cov kws kho hniav tau tshwm sim tsis ntev los no. Rov qab rau hauv lub xyoo pua puv 19, nws yog lub luag haujlwm ntawm tus kws tu plaub hau kom rub tawm cov hniav mob.

Qhov ua kom pom kev vibrator ua ntej nyob rau xyoo 19th. Nws ua haujlwm ntawm lub tshuab tso hluav taws xob thiab nws tau npaj kho qhov mob poj niam.

Cov poj niam feem ntau muaj peev xwm tau txais kev lom zem ntau dua los ntawm kev xav txog lawv lub cev zoo nkauj hauv daim iav dua li ntawm kev sib deev. Yog li, cov poj niam, siv zog ua kom muaj kev sib haum xeeb.

Tib neeg cov ntshav "khiav" los ntawm cov hlab ntsha hauv qab qhov siab, thiab yog tias nws txoj kev ncaj ncees tau ua txhaum, nws tuaj yeem tua txog 10 meters.

Polyoxidonium yog hais txog cov tshuaj tiv thaiv tshuaj tiv thaiv kab mob. Nws ua rau qee yam ntawm lub cev tsis muaj zog, yog li ua rau muaj kev ntseeg ruaj khov ntawm.

Cov lus qhia rau kev siv

Txhawm rau kom tsis txhob ua rau pom qhov tsis zoo los ntawm kev siv Lizpro insulin, koj yuav tsum ua raws nraim li cov lus qhia rau cov tshuaj no.

Qhov ntau npaum ntawm cov tshuaj nyob ntawm ntau cov nta. Qhov no cuam tshuam rau tus neeg mob lub hnub nyoog, daim ntawv ntawm tus kab mob thiab nws qhov mob hnyav, cov kab mob sib kis, thiab lwm yam Yog li ntawd, kev txiav txim qhov koob tshuaj yog qhov ua haujlwm ntawm tus kws kho mob koom.

Tab sis tus kws kho mob tshwj xeeb yuav yuam kev, yog li cov chav kawm ntawm kev kho mob yuav tsum tau saib xyuas tas li los soj ntsuam cov ntshav qab zib thiab kho cov kev kho mob. Tus neeg mob yuav tsum tau saib xyuas nws txoj kev noj qab haus huv zoo thiab qhia tus kws kho mob txog txhua yam kev tsis zoo ntawm lub cev mus rau yeeb tshuaj.

Tsim cov ntawv qhia chaw nyob li cas. Tab sis tsis zoo li feem ntau cov tshuaj zoo sib xws, kev txhaj tshuaj intramuscular tseem raug tso cai, ntxiv rau kev qhia cov tshuaj insulin rau hauv txoj hlab ntshav. Kev txhaj tshuaj rau hauv plab yuav tsum tau ua nrog kev koom tes ntawm tus kws kho mob.

Cov chaw zoo tshaj plaws rau kev txhaj tshuaj subcutaneous yog thaj chaw hauv ceg, lub xub pwg, lub pob tw, lub hauv pliaj xub thawj. Kev qhia ntawm cov tshuaj mus rau tib thaj chaw tsis raug tso cai, vim qhov no ua rau lipodystrophy. Yuav tsum muaj kev txav mus los hauv thaj chaw uas tau xaiv tseg.

Kev txhaj tshuaj yuav tsum tau ua nyob rau hauv ib lub sijhawm ntawm ib hnub. Qhov no yuav ua rau lub cev hloov kho thiab muab cov tshuaj insulin txuas ntxiv.

Nws yog ib qho tseem ceeb xav txog tus neeg mob tej teeb meem kev noj qab haus huv (tsis yog mob ntshav qab zib). Vim qee qhov ntawm lawv, cov nyhuv ntawm cov tshuaj no tuaj yeem ua rau txawv txav lossis qis dua. Hauv qhov no, koj yuav tsum tau rov qab suav lub koob tshuaj. Hauv kev sib txuas nrog lwm cov pathologies, tus kws kho mob feem ntau yuav txwv tsis pub siv cov Humalog.

Tshuaj ntsuab xuv xim video:

Cov yam ntxwv ntawm kev cuam tshuam nrog lwm yam tshuaj

Ib qho tseem ceeb heev ntawm kev siv tshuaj yog nws qhov kev sib raug zoo nrog lwm yam tshuaj. Cov kws kho mob feem ntau yuav tsum tau kho ob peb pathologies tib lub sijhawm, vim tias nws yog qhov tsim nyog los ua ke rau kev txais tos ntawm cov tshuaj sib txawv. Nws yog ib qho tsim nyog los teeb tsa txoj kev kho kom cov tshuaj tsis thaiv ntawm txhua qhov kev ua.

Qee zaum muaj qhov xav tau ntawm kev siv tshuaj uas tuaj yeem cuam tshuam qhov kev ua ntawm insulin.

Nws lub zog yog nce ntxiv yog tias, ntxiv rau nws, tus neeg mob siv cov tshuaj hauv qab no:

• Clofibrate
• Ketoconazole,
• MAO inhibitors
• sulfonamides.

Yog tias koj tsis tuaj yeem tsis kam lees txais lawv, koj yuav tsum txo qhov koob tshuaj ntawm nplooj ntawv qhia Humalog.

Cov yeeb tshuaj hauv qab no thiab cov pab pawg ntawm cov neeg sawv cev tuaj yeem ua kom tsis muaj zog ntawm cov tshuaj hauv nqe lus nug:

• estrogens
• nicotine
• tshuaj hormonal rau kev tiv thaiv,
• Glucagon.

Vim tias cov tshuaj no, qhov ua haujlwm ntawm Lizpro yuav txo qis qis, yog li tus kws kho mob yuav tau pom zoo kom nce ntxiv hauv cov tshuaj.

Qee cov tshuaj muaj qee yam tshwm sim tsis tau. Lawv muaj peev xwm nce ntxiv thiab txo qis kev ua haujlwm ntawm cov tshuaj nquag. Cov no suav nrog Octreotide, Pentamidine, Reserpine, beta-blockers.

Cov nqi thiab cov qauv ntawm cov tshuaj

Kev kho mob nrog Insulin Lyspro nws kim heev. Tus nqi ntawm ib pob ntawm cov tshuaj zoo li txawv ntawm 1800 txog 200 rubles. Nws yog vim tias tus nqi siab uas tus neeg mob qee zaum thov tus kws kho mob kom hloov cov tshuaj no nrog nws cov tshuaj tiv thaiv nrog cov nqi pheej yig dua.

Muaj ntau ntau cov analogues ntawm cov tshuaj no. Lawv raug nthuav tawm los ntawm cov ntawv sib txawv ntawm cov ntawv tso tawm, yuav txawv hauv lawv muaj pes tsawg leeg.

Ntawm cov neeg tseem ceeb tuaj yeem hais:

Qhov kev xaiv ntawm cov tshuaj los hloov cov hom insulin no yuav tsum tau muab rau tus kws tshwj xeeb.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm Humalog Mix 50 yog txiav txim los ntawm tus kws kho mob tshwj xeeb, nyob ntawm qhov xav tau ntawm tus neeg mob. Humalog® Mix 50 tuaj yeem siv tau tam sim ua ntej noj mov, thiab yog tias tsim nyog, sai tom qab noj mov. Cov tshuaj yuav tsum tau muab tsuas yog subcutaneously! Tso dej siab tswj hwm ntawm cov tshuaj Humalog Mix 50 contraindicated. Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov. Qhov tseeb ntawm txoj kev tswj tshuaj insulin yog tus kheej!

Txhaj tshuaj subcutaneous yuav tsum tau muab rau lub xub pwg, ncej puab, pob tw lossis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj li ib hlis ib zaug.

Nrog txoj kev tswj hwm ntawm Humalogane Mix 50, kev saib xyuas yuav tsum tau ceev faj kom tsis txhob nkag rau cov hlab ntshav thaum txhaj tshuaj. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws. Cov neeg mob yuav tsum tau kawm txog cov txheej txheem kev txhaj tshuaj kom raug.

Lub sijhawm ntawm cov tshuaj yuav txawv txav sib txawv ntawm ib tus neeg mus rau lwm tus thiab ntawm sijhawm sib txawv ntawm tib tus neeg. Lub sijhawm ua haujlwm ntawm Humalog® Mix 50 nyob ntawm lub koob tshuaj, chaw txhaj tshuaj, ntshav ntshav, qhov kub thiab lub cev ua si ntawm tus neeg mob.

Ua ntej yuav siv, Humalog® Sib tov 50 daim cartridge yuav tsum tau muab nruab nrab ntawm xib teg kaum npaug thiab tshee, tig ntawm 180 °, kaum zaug kom rov kho cov kua dej kom txog thaum nws dhau los ua kua dej tsis sib haum. Rov ua qhov txheej txheem no kom txog thaum cov ntsiab lus sib xyaw tag. Tsis txhob co ua kom muaj zog, vim tias qhov no tuaj yeem ua rau pom kev ua npuas, uas tuaj yeem cuam tshuam nrog koob tshuaj kom raug.

Cov cuab yeej ntawm cov cartridges tsis pub sib xyaw lawv cov ntsiab lus nrog lwm cov insulins ncaj qha hauv daim cartridge nws tus kheej. Cartridges tsis yog yuav tsum kom thim rov qab.

Cov ntsiab lus ntawm daim cartridges yuav tsum tau soj ntsuam tas li, thiab lawv yuav tsum tsis txhob siv lub ntsej muag, txhaws lossis nyob rau hauv rooj plaub ntawm kev nplaum ntawm cov khoom dawb dawb mus rau hauv qab lossis phab ntsa ntawm daim cartridge, muab nws ua kom tiav.

Nws yog ib qho tsim nyog yuav tsum tau ua raws li qhov chaw tsim khoom cov lus pom zoo rau txhua tus neeg xaum xaum thaum tso daim laub ntim, txuas lub koob, thiab txhaj cov Humalog® Mix 50.

Xaiv qhov chaw txhaj tshuaj.

Txau cov tawv nqaij ntawm qhov chaw txhaj tshuaj raws li cov lus qhia.

Tshem lub hau tiv thaiv sab nraud ntawm rab koob.

Kho cov tawv nqaij los ntawm kev khaws nws hauv qhov ntau quav.

Ntxig lub koob txhaj tshuaj subcutaneously raws li cov lus qhia.

Tshem tawm rab koob thiab maj mam nyem qhov chaw txhaj tshuaj nrog paj rwb pas nrig rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.

Siv cov txheej txheem tiv thaiv sab nraud ntawm lub koob, tshem tawm rab koob thiab pov tseg ntawm nws ua raws li kev cai nyab xeeb.

Nws yog ib qho tsim nyog yuav tsum tau hloov chaw txhaj tshuaj kom qhov chaw qub tsis siv ntau tshaj ib hlis ib zaug.

Cov Yuav Tsum Muaj

• ntshav qab zib,
• kev tsis qaug rau lub zog ntawm cov tshuaj.

Tsuas tshuaj thiab tswj hwm

Qhov ntau thiab tsawg ntawm cov tshuaj tau txiav txim los ntawm tus kws kho mob ib leeg zuj zus, ua rau qhov kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Qhov kev daws teeb meem yog txhaj tshuaj iv - yog tias tsim nyog, yog muaj mob ntawm cov kab mob pathologies, ketoacidosis, ntawm kev ua haujlwm thiab tom qab lub sijhawm txiav txim siab, s / c - nyob rau hauv daim ntawv ntawm kev txhaj tshuaj lossis ncua kev hno (dhau ntawm lub taub dej insulin) hauv plab, pob tw, lub duav lossis xub pwg, tsis yog cia cov khoom lag luam nkag rau hauv cov hlab ntshav. Cov chaw txhaj tshuaj hloov pauv txhua zaus, yog li thaj chaw tsis raug siv ntau tshaj 1 zaug hauv ib hlis. Tom qab tswj hwm, qhov chaw txhaj tshuaj tsis tuaj yeem raug muab tua pov tseg.

Hauv txhua kis, hom kev tswj hwm tus kheej tau teeb tsa tus kheej. Cov lus qhia yog nqa tawm sai ua ntej noj mov, tab sis kev siv cov tshuaj raug tso cai sai tom qab noj mov.

Npaj rau kev tswj hwm tshuaj

Ua ntej siv, txoj kev daws teeb meem tau soj ntsuam rau cov khoom tsis haum, ua kom nruj, staining thiab tuab. Tsuas yog siv cov xim tsis muaj xim thiab meej nyob rau hauv chav tsev.

Ua ntej kev txhaj tshuaj, ntxuav koj ob txhais tes kom huv, xaiv thiab so qhov chaw rau kev txhaj tshuaj. Tom ntej no, lub hau raug tshem tawm ntawm rab koob, daim tawv nqaij yog rub los yog sau rau hauv daim loj, rab koob tau tso rau hauv nws thiab lub pob yog nias. Tom qab ntawd, rab koob tau raug tshem tawm thiab rau ob peb vib nas this qhov chaw txhaj tshuaj yog ua tib zoo nias nrog paj rwb pas nrig. Los ntawm txoj kev tiv thaiv lub hau ntawm rab koob nws tau muab tso tseg thiab pov tseg.

Ua ntej siv Humalog nyob rau hauv qhov siv cwj mem-tshuaj (lub taub roj), QuickPen yuav tsum nyeem cov lus qhia rau kev siv.

Qhov kev txhaj tshuaj IV yog tau ua raws li kev kuaj mob ib txwm muaj, piv txwv, IV bolus txhaj tshuaj lossis hla ntawm cov tshuab infusion. Kev nquag saib xyuas cov ntshav qabzib yog qhov tseem ceeb.

Qhov kev ruaj khov ntawm txoj kev nqus ntshav nrog kev tsim kho ntawm 0.1-1 IU rau 1 ml ntawm insulin lispro hauv 5% dextrose lossis 0.9% sodium chloride tov rau 2 hnub yog muab thaum khaws cia hauv chav tsev kub.

Rau nqa tawm sc infusions, Disetronic thiab Minimed twj tsim rau cov tshuaj insulin infusions tuaj yeem siv. Nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov khw muag cov lus qhia thiab ua raws cov cai ntawm asepticism thaum sib txuas cov kab ke. Txhua txhua 2 hnub lawv hloov lub kaw lus rau txoj kev lis ntshav. Txoj kev lis ntshav nrog hypoglycemic rov qab nres yog kom txog thaum nws daws tau lawm. Thaum muaj cov ntshav qabzib tsawg nyob hauv cov ntshav, tus neeg mob yuav tsum sab laj nrog kws kho mob los txiav txim siab txo qis lossis tso tseg cov tshuaj insulin.

Kev nce siab ntxiv hauv cov ntshav qabzib hauv lub ntsej muag tuaj yeem pom nrog txoj kev txhaws rau txoj kev lis ntshav lossis lub mis tsis ua haujlwm. Yog tias ib qho kev ua txhaum ntawm cov tshuaj insulin xa mus ua rau xav tias yog vim li cas kev nce ntxiv hauv cov piam thaj, tus neeg mob yuav tsum ua raws li cov lus qhia ntawm lub chaw tsim khoom thiab qhia rau tus kws kho mob (yog tias tsim nyog).

Humalog thaum siv lub twj tso kua mis tsis tuaj yeem tov nrog lwm cov insulins.

QuickPen insulin cwj mem muaj 3 ml ntawm tshuaj nrog ib qho haujlwm ntawm 100 IU hauv 1 ml. 1-60 chav tsev ntawm insulin tuaj yeem muab rau ib qho kev txhaj tshuaj. Cov koob tshuaj tuaj yeem tsim nrog qhov tseeb ntawm ib chav. Yog tias ntau cov koog tau tsim tsa, cov koob tshuaj tuaj yeem hloov kho uas tsis muaj qhov poob ntawm insulin.

Lub koob txhaj tshuaj tsuas yog siv los ntawm ib tus neeg mob xwb, cov koob tshiab yuav tsum tau siv rau txhua qhov kev txhaj tshuaj. Tsis txhob siv cov txhaj tshuaj yog tias ib qho ntawm nws feem raug piam lossis tawg. Tus neeg mob yuav tsum nqa lub tshuab nqus dej tas li yog poob lossis puas.

Cov neeg mob uas tsis pom kev tsis pom kev lossis tsis pom kev zoo tsis pom zoo kom siv cov koob tshuaj tsis tas yuav tsum tau txais kev pab zoo los ntawm cov neeg pom kom tau kawm siv nws.

Ua ntej txhua txoj kev txhaj tshuaj, nws yog ib qho tseem ceeb kom paub meej tias lub hnub tas sij hawm uas tau qhia ntawm daim ntawv lo tsis tau tas sij hawm thiab tias hom insulin tseeb muaj nyob hauv lub koob. Hauv qhov no, nws tsis pom zoo kom tshem daim ntawv lo ntawm nws.

Cov xim ntawm cov xim khawm ceev ntawm QuickPen syringe cwj mem yog grey, nws phim cov xim ntawm cov kab txaij rau ntawm nws daim ntawv lo thiab cov tshuaj insulin siv.

Ua ntej siv cov hno, koj yuav tsum xyuas kom tseeb tias rab koob tau txuas ntawm nws. Tom qab siv, rab koob raug tshem tawm thiab pov tseg. Cov xaum xaum yuav tsis khaws cia nrog rab koob txuas rau nws, vim qhov no yuav ua rau huab cua npuas los ua rau hauv lub thawv tshuaj.

Thaum sau ntawv yuav ib koob tshuaj dhau ntawm 60 units, ob qhov kev txhaj tshuaj.

Txhawm rau kuaj cov tshuaj insulin hauv daim cartridge, koj yuav tsum tau taw lub taub hau nrog lub taub ntawm rab koob nce thiab pom tus naj npawb ntawm cov seem ntawm cov tshuaj insulin rau ntawm cov nplai ntawm lub pob tshab yas dhos.Qhov ntsuas no tsis yog siv los teeb lub koob tshuaj.

Txhawm rau kom tshem lub hau ntawm lub injector, koj yuav tsum rub nws. Yog tias muaj teeb meem tshwm sim, ua tib zoo tig lub hau moos ntawm moos thiab counterclockwise, thiab tom qab ntawd rub nws.

Txhua lub sijhawm ua ntej txhaj tshuaj, lawv tshawb xyuas cov tshuaj insulin kom tsawg, vim tias tsis muaj nws koj tuaj yeem tau txais insulin ntau dhau lossis muaj ntau dhau. Txhawm rau tshuaj xyuas, tshem tawm lub hau sab nraud thiab sab hauv ntawm rab koob, los ntawm tig lub pob koob tshuaj, 2 chav nyob yog teeb tsa, lub taub tso ntshav tau ncaj qha mus sab hauv thiab khob qhov rooj ntawm lub laub kom cov pa tag nrho cov pa tuaj sau nyob rau sab saud. Tom qab ntawd nias lub pob koob tshuaj kom txog thaum nws nres thiab tus lej 0 tshwm nyob rau hauv lub qhov ntsuas qhov ntsuas tshuaj. Tuav lub khawm nyob rau hauv txoj haujlwm recessed, maj mam suav mus rau 5, lub sijhawm no lub pob tshuaj insulin yuav tsum tshwm sim thaum kawg ntawm rab koob. Yog hais tias qhov ua kom yuam kev ntawm insulin tsis tshwm sim, lub koob tau hloov nrog lub tshiab thiab rov qab xeem yog nqa tawm.

Kev tswj hwm tshuaj

• tshem lub hau ntawm cwj mem syringe
• nrog ib qho qhwv ntaws nrog dej cawv, so lub roj hmab disc ntawm qhov kawg ntawm lub cartridge,
• muab rab koob tso rau hauv lub hau ncaj ncaj rau ntawm lub axis ntawm lub taub hau thiab ntsuas hau kom txog thaum nws txuas kiag li,
• los ntawm kev hloov cov koob tshuaj khawm, qhov yuav tsum tau muaj ntawm cov tau teeb tsa,
• tshem lub hau ntawm rab koob thiab ntxig rau hauv qab daim tawv nqaij,
• nrog koj tus ntiv tes xoo, nias lub khawm koob tshuaj kom txog thaum nws nres kiag li. Txhawm rau nkag mus rau qhov tshuaj tag nrho, tuav lub pob thiab maj mam suav rau 5,
• lub koob raug tshem tawm hauv qab ntawm daim tawv nqaij,
• xyuas qhov ntsuas qhov koob tshuaj - yog tias nws muaj tus lej 0 rau nws, cov koob tshuaj tau sau tiav lawm,
• ua tib zoo muab lub hau ntim rau ntawm rab koob thiab muab nws rho tawm ntawm cov koob, mam li muab pov tseg.
• muab lub hau kaw rau ntawm tus cwj mem xaum qhuav.

Yog tias tus neeg mob xav tias nws tau siv tag nrho cov tshuaj, tsis tas yuav rov qab noj dua.

Sab sij huam

• feem ntau ntau: hypoglycemia (hauv qhov xwm txheej loj, nws tuaj yeem ua rau kev txhim kho hypoglycemic coma, tshwj tsis yog mob - tuag),
• ua tau: lipodystrophy, kev tsis haum tshuaj hauv zos - o, liab lossis khaus ntawm qhov chaw txhaj tshuaj,
• tsis tshua muaj: muaj kev tsis haum rau lub cev dav dav - nce tawm hws, tachycardia, txo ntshav siab, ua tsis taus pa, kub taub hau, mob caj dab, mob urticaria, khaus thoob plaws lub cev.

Cov lus qhia tshwj xeeb

Hloov chaw ntawm tus neeg mob mus rau lwm lub npe lossis hom tshuaj insulin yog ua tiav los ntawm kev saib xyuas mob nkeeg nruj. Yog tias koj hloov hom kev tsim khoom, hom, hom, hom thiab / lossis kev ua ub no, yuav tau kho kom haum cov koob tshuaj.

Cov tsos mob uas cuam tshuam txog kev txhim kho hypoglycemia tej zaum yuav tsawg tshaj tawm thiab tsis tseem ceeb nrog kev kho mob hnyav nrog insulin, kev muaj sia nyob ntev ntawm ntshav qab zib mellitus, kab mob ntawm cov hlab ntshav tawm tsam tiv thaiv ntshav qab zib mellitus, thiab tib lub sij hawm kho nrog tshuaj, piv txwv li beta-blockers.

Cov tsos mob thaum ntxov ntawm hypoglycemia rau cov neeg mob hypoglycemic tshua tom qab hloov los ntawm tsiaj insulin rau tib neeg cov tshuaj insulin yuav tsis tshua hnyav lossis txawv ntawm cov uas lawv tau muaj nrog insulin yav dhau los thaum kho.

Thaum tsis nco qab mob hyperglycemic lossis hypoglycemic tshua, kev loj hlob ntawm qhov tsis nco qab, tsis nco qab, lossis pib ntawm txoj kev tuag yog ua tau. Siv cov tshuaj tsis haum tshuaj lossis tsis tuaj yeem kho kev kho mob, tshwj xeeb tshaj yog rau hom ntshav qab zib hom mellitus, tuaj yeem ua rau kev loj hlob ntawm hyperglycemia thiab ntshav qab zib ketoacidosis, uas muaj peev xwm hem tus neeg mob lub neej.

Hauv lub raum thiab hepatic qhov tsis txaus, nws tuaj yeem txo qhov kev xav tau rau insulin, uas cuam tshuam nrog txo qis ntawm cov tshuaj insulin metabolism thiab gluconeogenesis cov txheej txheem. Hauv kev mob siab ua haujlwm ntev (vim tias muaj peev xwm tiv thaiv cov tshuaj insulin ntau dua), kev nyuaj siab ntxhov siab, kis kab mob, kev nce siab ntawm cov khoom noj carbohydrates hauv zaub mov, qhov xav tau insulin yuav nce ntxiv.

Thaum muaj kev hloov pauv ntawm kev noj zaub mov noj ib txwm thiab muaj dag zog rau lub cev, kev hloov tshuaj ntau dua yuav raug. Thaum ua cov kev tawm dag zog lub cev tam sim ntawd tom qab noj mov, nws muaj peev xwm nce ntxiv ntawm kev pheej hmoo ntawm hypoglycemia. Vim yog lub chaw muag tshuaj ntawm kev ua haujlwm sai ntawm tib neeg cov tshuaj insulin, hypoglycemia yuav tshwm sim thaum ntxov tom qab txhaj tshuaj dua thaum siv cov tshuaj lom neeg insulin.

Thaum sau cov tshuaj insulin npaj nrog qhov sib xyaw ntawm 40 IU hauv 1 ml hauv lub vial, nws tsis tuaj yeem cia cov tshuaj insulin los ntawm daim cartridge nrog cov tshuaj insulin ntawm 100 IU hauv 1 ml siv koob txhaj tshuaj rau insulin nrog rau 40 IU hauv 1 ml.

Kev kho ib txhij nrog insulin npaj nrog tshuaj ntawm thiazolidinedione pab pawg nce qhov kev pheej hmoo ntawm kev txhim kho edema thiab mob plawv tsis ua hauj lwm, tshwj xeeb tshaj yog tiv thaiv cov keeb kwm yav dhau los ntawm kab mob ntawm cov hlab plawv thiab nyob rau ntawm qhov muaj kev pheej hmoo rau mob plawv tsis ua haujlwm.

Cov neeg mob thaum kho yuav tsum ua tib zoo saib xyuas thaum tsav tsheb thiab ua cov haujlwm muaj kev phom sij uas yuav tsum muaj kev saib xyuas ntau dua thiab nrawm rau cov kev puas hlwb.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv ntawm tshuaj / tshuaj rau ntawm insulin lispro nrog kev kho ua ke:

• phenothiazine derivatives, nicotinic acid, lithium carbonate, isoniazid, diazoxide, chlorprotixene, thiazide diuretics, tricyclic antidepressants, beta-2-adrenergic agonists (terbutaline, salbutamol, ritodrin, thiab lwm yam), danazole, thyroid-muaj cov thyroid hormones: qhov heev ntawm nws cov hypoglycemic nyhuv,
• angiotensin II receptor antagonists, octreotide, angiotensin-converting enzyme inhibitors (enapril, captopril), qee cov tshuaj tiv thaiv kab mob (monoamine oxidase inhibitors), tshuaj tua kab mob sulfanilamide, salicylates (acetylsalicylic acid, thiab lwm yam, tshuaj phenolic, tetragenurolinogens, tshuaj tiv thaiv hypoglycrogen ethanol thiab ethanol-muaj cov tshuaj, beta-blockers: nce qhov hnyav ntawm nws cov nyhuv hypoglycemic.

Lyspro insulin tsis tov nrog tsiaj cov tshuaj insulin.

Ua ntej noj lwm yam tshuaj, nws yog ib qho tseem ceeb kom sab laj nrog kws kho mob. Ntawm nws qhov kev pom zoo, cov tshuaj yeeb yaj kiab tuaj yeem siv ua ke nrog cov kua dej hauv tib neeg ntev ntev los yog nrog cov ncauj lus ntawm sulfonylureas.

Cov qauv ntawm Humalog yog Iletin I tsis tu ncua, Iletin II tsis tu ncua, Nruab Nrab SPP, Nruab Nrab HM, Farmasulin.

Cov lus thiab cov xwm txheej ntawm kev cia

Khaws nyob rau ntawm 2-8 ° C hauv lub tub yees, hauv ib rab koob xaum / cartridge - txog li 30 ° C rau 4 lub lis piam. Khaws tsis ncav cuag ntawm cov menyuam yaus.

Txee lub neej yog 3 xyoos.

Cov Cai Siv Tshuaj So

Tso tawm los ntawm kev kho mob.

Pom qhov yuam kev hauv cov ntawv nyeem? Xaiv nws thiab nias Ctrl + Enter.

Dua li ntawm qhov tseeb hais tias cov kws tshawb fawb tswj tau kom rov ua tiav cov tshuaj insulin molecule, uas tsim tawm hauv tib neeg lub cev, qhov kev ua ntawm cov tshuaj hormones tseem ua rau qeeb qeeb vim lub sijhawm xav kom nqus mus rau hauv cov ntshav. Thawj cov tshuaj ntawm kev ua kom zoo dua yog cov tshuaj insulin Humalog. Nws pib ua haujlwm tau ntev lawm 15 feeb tom qab txhaj tshuaj, yog li ntawd cov suab thaj los ntawm cov ntshav pauv mus rau cov ntaub so ntswg hauv lub sijhawm, thiab txawm tias lub sijhawm luv luv hyperglycemia tsis tshwm sim.

Nws yog ib qho tseem ceeb kom paub! Ib yam tshiab tawm tswv yim los ntawm endocrinologist rau Saib Xyuas Ntshav Qab Zib Ntxiv! Nws tsuas yog tsim nyog txhua hnub.

Piv nrog cov neeg tsim insulins yav dhau los, Humalog qhia tau zoo dua: hauv cov neeg mob, txhua hnub hloov pauv hauv qab zib yog li 22%, glycemic qhov ntsuas tau zoo, tshwj xeeb tshaj yog yav tav su, thiab qhov muaj feem yuav ua rau muaj ntshav siab qeeb tsawg dua. Vim tias qhov nrawm nrawm, tab sis qhov kev txiav txim ruaj khov, qhov insulin no nce hauv kev mob ntshav qab zib.

Qhia me ntsis

Cov lus qhia txog kev siv tshuaj insulin Humalog yog qhov hluav taws xob heev, thiab cov ntu piav qhia txog kev phiv thiab cov lus qhia rau kev siv nyob ntau dua ib kab lus. Cov lus piav qhia ntev ntev uas sib xyaw nrog qee cov tshuaj tau pom los ntawm cov neeg mob yog lus ceeb toom txog kev phom sij ntawm kev coj lawv. Qhov tseeb, txhua yam muaj qhov sib txawv: ib qho loj, cov lus qhia ntxaws ntxaws - cov ntaub ntawv pov thawj ntawm ntau yam kev sim siab tias cov tshuaj no thev taus zoo.

Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los

Mob ntshav qab zib yog qhov ua rau ze li ntawm 80% ntawm tag nrho cov cwj nrag thiab txiav taws. 7 ntawm 10 leej neeg tuag vim txhaws ntawm cov hlab ntsha hauv plawv lossis paj hlwb. Yuav luag txhua qhov teeb meem, qhov laj thawj rau qhov txaus ntshai kawg no yog qhov qub - ntshav qab zib siab.

Cov piam thaj tuaj yeem thiab yuav tsum tau sib khob, tsis muaj dab tsi. Tab sis qhov no tsis kho tus kab mob nws tus kheej, tab sis tsuas yog pab txhawm rau txhawm rau tshawb xyuas, thiab tsis yog qhov ua kom muaj tus kab mob.

Cov tshuaj nkaus xwb uas raug pom zoo rau kev kho mob ntshav qab zib thiab nws kuj yog siv los ntawm endocrinologist hauv lawv txoj haujlwm yog qhov no.

Qhov ua tau zoo ntawm cov tshuaj, suav raws li tus qauv txheej txheem (tus naj npawb ntawm cov neeg mob uas tau zoo mus rau tag nrho cov neeg mob hauv pawg 100 ntawm cov neeg tau txais kev kho mob) yog:

• Li qub ntawm qab zib - 95%
• Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
• Ntaus tau ntawm lub plawv dhia muaj zog - 90%
• Kev tshem tawm ntshav siab - 92%
• Ntxiv dag zog rau nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj - 97%

Cov neeg tsim khoom tsis yog lub koom haum ua lag luam thiab tau nyiaj peev nrog kev txhawb nqa los ntawm lub xeev. Yog li ntawd, tam sim no txhua tus neeg nyob hauv muaj qhov zoo.

Humalogue tau txais kev pom zoo rau kev siv ntau dua 20 xyoo dhau los, thiab tam sim no nws muaj kev ruaj ntseg hais tias cov tshuaj insulin no muaj kev nyab xeeb ntawm kev siv tshuaj. Nws tau txais kev pom zoo rau kev siv los ntawm ob tus neeg laus thiab menyuam yaus, tuaj yeem siv rau txhua tus neeg mob, nrog rau qhov tsis muaj suab yam tshuaj: hom 1 thiab ntshav qab zib hom 2, phais mob pancreatic.

Cov ntaub ntawv dav dav txog qhov Humalogue:

Ntawm cov kev mob tshwm sim, hypoglycemia thiab kev fab tshuaj tsis haum yog feem ntau pom (1-10% ntawm neeg mob ntshav qab zib). Tsawg dua 1% ntawm cov neeg mob tsim muaj lipodystrophy ntawm thaj chaw txhaj tshuaj. Qhov ntau zaus ntawm lwm cov kev tsis sib haum yog tsawg dua 0.1%.

Qhov tseem ceeb tshaj plaws txog Humalog

Nyob hauv tsev, Humalog yog muab subcutaneously siv rab koob xaum qhuav los yog. Yog tias muaj mob loj heev yuav tsum raug tshem tawm, kev tswj hwm cov tshuaj no kuj tuaj yeem ua rau hauv cov chaw kho mob. Hauv qhov no, nquag tswj cov piam thaj yog qhov tsim nyog kom tsis txhob noj ntau dhau.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj yog insulin lispro. Nws txawv ntawm tib neeg cov tshuaj hormones hauv kev npaj cov amino acids hauv cov qauv molecule. Xws li kev hloov kho tsis tiv thaiv cov cell receptors los ntawm kev paub txog cov tshuaj hormones, yog li lawv yooj yim dhau suab thaj rau lawv tus kheej Qhov humalogue tsuas muaj cov tshuaj insulin monomers - ib qho, tsis txuas yam tsis txawv. Vim tias qhov no, nws yog nqus tau nrawm thiab tusyees, pib txo cov piam thaj sai dua li cov tshuaj insulin tsis haum.

Qhov tshuaj tiv thaiv tshuaj yog qhov yeeb tshuaj luv dua li, piv txwv, lossis. Raws li kev faib tawm, nws tau xa mus rau cov tshuaj insulin sib piv nrog cov kev ua kom haum. Qhov pib ntawm nws cov kev ua tau nrawm dua, li 15 feeb, yog li cov neeg mob ntshav qab zib tsis tas tos kom txog thaum cov tshuaj ua haujlwm, tab sis koj tuaj yeem npaj zaub mov noj tom qab txhaj tshuaj. Ua tsaug rau qhov tsis txaus no, nws yuav yooj yim rau kev npaj zaub mov noj, thiab qhov kev pheej hmoo tsis nco qab cov zaub mov tom qab kev txhaj tshuaj yog txo qis dua.

Rau kev tswj cov glycemic zoo, cov neeg sawv cev nrawm yuav tsum tau ua ke nrog kev siv. Tib qho kev zam tsuas yog kev siv lub tshuab nqus dej twj tso kua mis rau ntawm lub sijhawm txuas ntxiv.

Xaiv xaiv

Kev noj tshuaj Humalog ntau nyob ntawm ntau yam thiab txiav txim siab ntawm tus kheej rau txhua tus mob ntshav qab zib. Kev siv cov qauv txheem yog tsis pom zoo, vim tias lawv ua rau kev mob ntshav qab zib hnyav dua. Yog tias tus neeg mob ua raws li cov zaub mov uas tsis muaj carbohydrate tsawg, qhov koob tshuaj ntawm Humalog yuav tsawg dua li cov qauv ntawm kev tswj hwm tuaj yeem muab tau. Hauv qhov no, nws pom zoo kom siv cov tshuaj insulin uas tsis muaj zog tuaj.

Ultrashort cov tshuaj hormones muab cov nyhuv loj tshaj. Thaum hloov mus rau Humalog, nws qhov kev pib noj tshuaj yog xam raws li 40% ntawm kev siv insulin luv luv. Raws li cov txiaj ntsig ntawm glycemia, ntau npaum li cas tau kho. Qhov xav tau qhov nruab nrab ntawm kev npaj rau ib khob cij yog 1-1.5 units.

Cov qauv kev txhaj tshuaj

Lub humalogue yog pricked ua ntej txhua pluas noj, tsawg kawg peb zaug hauv ib hnub Cov. Nyob rau hauv cov ntaub ntawv ntawm cov piam thaj siab, kho cov menyuam hlob nyob nruab nrab ntawm kev txhaj tshuaj tseem ceeb raug tso cai. Cov kev qhia rau kev siv pom zoo xam lub xav tau cov tshuaj insulin raws li cov khoom noj uas tau npaj rau kev noj mov tom ntej. Txog 15 feeb yuav tsum dhau los ntawm kev txhaj tshuaj mus rau cov zaub mov.

Raws li kev txheeb xyuas, lub sijhawm no feem ntau tsawg dua, tshwj xeeb yog thaum tav su, thaum cov tshuaj tiv thaiv insulin tsawg dua. Qhov nqus tus nqi yog nruj me ntsis rau ib tus neeg, nws tuaj yeem raug suav siv rov ua ntsuas ntsuas cov ntshav qab zib sai sai tom qab txhaj. Yog tias cov ntshav qab zib ua rau pom qhov cuam tshuam sai dua li cov lus qhia, lub sijhawm ua ntej noj mov yuav tsum raug txo kom tsawg.

Humalog yog ib qho tshuaj sai tshaj plaws, yog li nws yooj yim siv nws ua kev pabcuam xwm txheej ceev rau cov ntshav qab zib, yog tias tus neeg mob raug hem.

Lub sijhawm ua haujlwm (luv lossis ntev)

Lub ncov ntawm ultrashort insulin yog pom 60 feeb tom qab nws tswj hwm. Lub sijhawm ua haujlwm nyob ntawm lub koob tshuaj; qhov loj dua nws yog, ntev li ntawm cov suab thaj txo qis dua yog nyob hauv nruab nrab - kwv yees li 4 teev.

Neej Neeg tshaj 25

Txhawm rau kom ntsuas qhov tseeb ntawm qhov tshwm sim ntawm Humalog, qabzib yuav tsum tau ntsuas tom qab lub sijhawm no, feem ntau qhov no ua tiav ua ntej noj mov tom ntej. Kev ntsuas ua ntej yog xav tau yog xav tias tsam lub qog ntshav qab zib tsawg.

Tus kws kho mob ntawm Kev Tshawb Fawb Kev Kho Mob, Lub Taub Hau ntawm Lub Tsev Kawm ntawm Diabetology - Tatyana Yakovleva

Kuv tau kawm mob ntshav qab zib tau ntau xyoo. Nws yog txaus ntshai thaum muaj coob tus neeg tuag, thiab haj yam ua rau neeg xiam vim ntshav qab zib.

Kuv maj nrawm nroos los qhia txoj xov zoo - Endocrinological qhov chaw tshawb fawb ntawm Lavxias Academy ntawm Medical Science tau tswj los tsim cov tshuaj uas kho cov ntshav qab zib kom tiav. Thaum lub sijhawm, cov hauj lwm zoo ntawm cov tshuaj no tau nce mus txog 98%.

Lwm qhov xov xwm zoo: Lub Chaw Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau ua ib txoj kev saws me nyuam los them rau cov nqi tshuaj ntau heev. Hauv Lavxias, neeg mob ntshav qab zib kom txog lub Peb Hlis 2 tuaj yeem tau txais nws - Tsuas yog 147 rubles!

Lub sijhawm luv luv ntawm lub Humalog tsis yog qhov ua tsis zoo, tab sis qhov zoo ntawm cov tshuaj. Ua tsaug rau nws, cov neeg mob ntshav qab zib mellitus tsis tshua muaj kev tiv thaiv ntshav qab zib, tshwj xeeb tshaj yog thaum tsaus ntuj.

Neej Neeg Sib

Ntxiv rau qhov Humalog, lub tuam txhab kev lag luam kws tsim tshuaj Lilly France tsim cov Humalog Mix. Nws yog kev sib xyaw ntawm lyspro insulin thiab protamine sulfate. Ua tsaug rau qhov kev sib txuam no, lub sijhawm pib ntawm cov tshuaj hormone tseem zoo li qub, thiab lub sijhawm ua haujlwm tau nce ntxiv.

Humalog Mix yog muaj nyob rau hauv 2 ntau qhov:

Qhov zoo dua ntawm cov tshuaj no yog cov tshuaj txhaj yooj yim dua. Kev tiv thaiv kab mob ntshav qab zib mellitus thaum lawv siv yog qhov phem dua li nrog kev kho mob ntxiv ntawm kev siv tshuaj insulin thiab kev siv Humalog li ib txwm, yog li ntawd, rau cov me nyuam Humalog Mix tsis siv .

Qhov tshuaj insulin no tau sau tseg:

1. Cov neeg mob ntshav qab zib uas tsis tuaj yeem xam tus kheej ntawm koob tshuaj lossis ua ib qho kev txhaj tshuaj, piv txwv, vim tsis pom kev tsis zoo, tuag tes tuag taw lossis tshee.
2. Cov neeg mob mob hlwb.
3. Cov neeg laus uas muaj ntau yam mob ntshav qab zib thiab kev paub tsis zoo txog kev kho yog tias lawv tsis kam kawm.
4. Tus neeg mob ntshav qab zib nrog hom 2 yog tias nws tus kheej tawm los tsim.

Kev kho mob ntshav qab zib nrog Humalog Mix yuav tsum noj zaub mov kom nruj, yuav tsum noj khoom txom ncauj thaum noj mov. Nws raug tso cai noj 3 XE rau noj tshais, txog 4 XE rau noj su thiab noj hmo, txog 2 XE rau noj hmo, thiab 4 XE ua ntej yuav mus pw.

Cov Kev Tshaj Tawm ntawm Humalog

Lyspro insulin raws li cov tshuaj nquag muaj tsuas yog nyob hauv thawj phau ntawv teev npe. Cov tshuaj uas ze ze yog (raws li aspart) thiab (glulisin). Cov cuab yeej no tseem yog ultra-luv, yog li nws tsis muaj teeb meem twg uas yuav tsum xaiv. Txhua tus tau txais txiaj ntsig zoo thiab muab cov suab thaj txo ntau. Raws li txoj cai, kev nyiam yog muab rau cov tshuaj, uas tuaj yeem muab pub dawb hauv chaw kho mob.

Qhov kev hloov pauv ntawm Humalog mus rau nws txoj kab ke paum yuav tau tsim nyog muaj kev fab ua txhaum. Yog tias tus mob ntshav qab zib ua raws li cov zaub mov uas tsis muaj carb ntau, lossis feem ntau muaj ntshav qab zib hauv lub cev, nws yog qhov muaj kuab siv tib neeg ntau dua li siv cov tshuaj insulin.

Nco ntsoov kawm! Koj puas xav tias kev tswj hwm kev noj qab haus huv ntawm cov tshuaj thiab cov kua dej yog ib txoj kev los tswj cov piam thaj kom tswj? Tsis muaj tseeb! Koj tuaj yeem soj ntsuam qhov no koj tus kheej los ntawm kev pib siv nws.

DNA recombinant tib neeg cov tshuaj insulin.
Npaj: HUMALOG®
Cov tshuaj nquag ntawm cov tshuaj: tshuaj insulin lyspro
ATX Encoding: A10AB04
KFG: Ua yeeb yam rau neeg lub cev tsis txaus siab
Npe sau npe: P No. 015490/01
Hnub sau npe: 02.02.04
Tswv reg reg. acc .: LAGY FRANCE S.A.S.

Kev daws rau kev txhaj tshuaj yog pob tshab, tsis muaj kob.

1 ml
tshuaj insulin lispro *
100 IU

Cov kev zam: glycerol, zinc oxide, sodium hydrogen phosphate, m-cresol, dej d / thiab, hydrochloric acid daws ntawm 10% thiab sodium hydroxide tov ntawm 10% (los tsim kom muaj qib pH uas yuav tsum tau).

3 ml - cartridges (5) - hlwv (1) - pob khoom los ntawm cardboard.

* Lub npe tsis yog thoob ntiaj teb uas pom zoo los ntawm WHO, hauv Lavxias teb sab lus, sau tus npe ntawm lub npe thoob ntiaj teb - insulin lispro raug lees txais.

Cov lus piav qhia ntawm cov tshuaj yog ua raws cov lus qhia raug pom zoo rau kev siv.

Pharmacological ua Humalog

DNA recombinant tib neeg cov tshuaj insulin. Nws txawv ntawm qhov kawg hauv kev rov ua dua ntawm cov amino acids ntawm txoj haujlwm 28 thiab 29 ntawm cov kab hluav taws xob insulin B.

Lub txiaj ntsig tseem ceeb ntawm cov tshuaj yog kev tswj hwm ntawm cov metabolism hauv qab ntuj. Tsis tas li ntawd, nws muaj qhov ua kom anabolic. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Hauv cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib mellitus, thaum siv cov tshuaj insulin lyspro, hyperglycemia uas tshwm sim tom qab noj mov tau nce ntau dua piv rau kev tiv thaiv tib neeg cov kua dej. Rau cov neeg mob tau txais cov tshuaj insulins luv luv thiab hauv paus, nws yog ib qho tsim nyog yuav tsum xaiv cov koob tshuaj ntawm ob qho insulins thiaj li ua tiav cov ntshav qabzib kom zoo thoob plaws ib hnub.

Ib yam li txhua qhov kev npaj tshuaj insulin, lub sijhawm lyspro insulin ua haujlwm tuaj yeem sib txawv hauv cov neeg mob lossis sijhawm sib txawv ntawm tib tus neeg mob thiab nyob ntawm lub koob tshuaj, chaw txhaj tshuaj, ntshav ntshav, kub cev thiab kev tawm dag zog.

Cov yam ntxwv ntawm lyspro insulin hauv cov menyuam yaus thiab cov hluas yog cov zoo sib xws ntawm cov neeg laus saib.

Hauv cov neeg mob uas muaj ntshav qab zib hom 2 tau txais cov tshuaj sulfonylurea ntau tshaj plaws, qhov ntxiv ntawm lyspro insulin ua rau txo qis glycosylated hemoglobin.

Lyspro insulin kho nyob rau hauv cov neeg mob uas muaj hom 1 thiab ntshav qab zib hom 2 yog nrog nws cov neeg tsawg zuj zus mus ntawm nocturnal hypoglycemia.

Qhov glucodynamic lo lus teb rau isulin lispro tsis vam khom rau kev ua haujlwm tsis zoo ntawm lub raum lossis nplooj siab.

Lyspro insulin tau pom tias yog ua kom sib luag rau tib neeg cov tshuaj insulin, tab sis nws cov kev ua tshwm sim sai dua thiab kav rau lub sijhawm luv.

Lyspro insulin yog tus cwj pwm los ntawm qhov pib sai ntawm kev coj ua (li 15 feeb), raws li Nws muaj qhov nqus dej siab, thiab qhov no tso cai rau koj nkag mus rau nws tam sim ntawd ua ntej noj mov (0-15 feeb ua ntej noj mov), hauv kev sib piv rau cov pa luv luv ua yeeb yam (30-45 feeb ua ntej noj mov). Lyspro insulin muaj lub sijhawm luv dua (2 mus rau 5 teev) piv rau tib neeg cov tshuaj insulin.

Pharmacokinetics ntawm cov tshuaj.

Xuas thiab faib khoom

Tom qab cov tswj hwm sc, insulin Lyspro nrawm nrawm thiab mus txog Cmax hauv ntshav ntshav tom qab 30-70 feeb. Vd ntawm insulin lyspro thiab insulin tib neeg zoo ib yam thiab muaj nyob ntawm thaj tsam ntawm 0.26-0.36 l / kg.

Nrog sc tswj kev tswj hwm ntawm T1 / 2 ntawm insulin, lyspro yog li 1 teev. Cov neeg mob raum thiab mob hepatic tsis txaus muaj qhov feem ntau ntawm kev nqus ntawm lyspro insulin piv rau cov tshuaj insulin rau tib neeg.

Kev taw qhia rau kev siv:

Mob ntshav qab zib mellitus hauv cov neeg laus thiab cov menyuam yaus, xav tau kev kho tshuaj insulin kom muaj cov suab thaj hauv lub cev.

Dosage thiab txoj hauv kev ntawm kev tswj hwm tshuaj.

Tus kws kho mob txiav txim siab muab koob tshuaj ib leeg zuj zus, nyob ntawm qhov xav tau ntawm tus neeg mob. Cov tshuaj Humalog tuaj yeem muab sai ua ntej noj mov, yog tias tsim nyog - sai sai tom qab noj mov.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov.

Qhov tshuaj Humalog yog muab sc rau hauv txoj kev txhaj tshuaj lossis hauv daim ntawv ntawm ncua ntev inf infusion siv lub twj tso kua mis.Yog tias tsim nyog (ketoacidosis, mob hnyav, lub sijhawm ntawm kev ua haujlwm lossis sijhawm hla sijhawm) Humalog tuaj yeem nkag mus rau hauv / hauv.

SC yuav tsum muab rau lub xub pwg, ncej puab, pob tw, lossis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj 1 zaug hauv ib hlis. Thaum s / qhia txog cov tshuaj Humalog, yuav tsum saib xyuas kom tsis txhob txais cov tshuaj rau hauv cov hlab ntsha. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws. Tus neeg mob yuav tsum tau kawm siv cov txheej txheem kev txhaj tshuaj kom raug.

Cov kev cai rau kev tswj hwm ntawm cov tshuaj Humalog

Npaj rau kev qhia

Kev daws ntawm cov tshuaj Humalog yuav tsum yog pob tshab thiab xim tsis muaj xim. Ib qho huab, tuab lossis xim me ntsis ntawm cov tshuaj, lossis yog tias cov khoom tawg tau pom los rau hauv nws, yuav tsum tsis txhob siv.

Thaum txhim kho lub taub ntim hauv cov koob txhaj tshuaj (tus cwj mem-txhaj), txuas lub koob thiab coj kev txhaj tshuaj insulin, nws yog qhov yuav tsum tau ua raws li cov khw muag cov lus qhia uas txuas nrog txhua tus xaum xim.

2. Xaiv lub xaib rau kev txhaj tshuaj.

3. Tshuaj tua kab mob los kho cov tawv nqaij ntawm qhov chaw txhaj tshuaj.

4. Tshem tawm lub hau ntawm rab koob.

5. Kho cov tawv nqaij los ntawm kev ncab nws lossis los ntawm kev ruaj ntseg ntawm cov quav loj. Ntxig lub koob txhaj tshuaj raws li cov lus qhia siv kev xaum xim.

6. Nias lub pob ntawd.

7. Tshem tawm rab koob thiab maj mam nyem qhov chaw txhaj tshuaj rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.

8. Kev siv rab koob rab koob, tshem tawm rab koob thiab rhuav tshem nws.

9. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom qhov chaw qub siv tsis ntau tshaj li 1 zaug hauv ib hlis.

Kev tswj hwm ntawm insulin

Kev txhaj tshuaj tiv thaiv ntawm Humalog yuav tsum tau nqa tawm raws li kev siv tshuaj txhaj rau txoj kev txhaj tshuaj, piv txwv, txhaj tshuaj bolus tswj lossis siv cov txheej txheem infusion. Hauv qhov no, nws yog ib qho tsim nyog feem ntau los tswj cov qib ntawm cov piam thaj hauv cov ntshav.

Lub tshuab ua ke nrog cov ntsiab lus los ntawm 0.1 IU / ml txog rau 1.0 IU / ml insulin lispro hauv 0.9% sodium chloride tov lossis 5% dextrose daws yog ruaj khov nyob rau hauv chav tsev rau 48 teev.

P / C insulin infusion siv lub twj tso kua mis

Rau kev ua txhaum ntawm cov tshuaj Humalog, Minimed thiab Disetronic cov twj tso kua mis tuaj yeem siv rau cov tshuaj insulin. Koj yuav tsum nruj me ntsis ua raws cov lus qhia uas tuaj nrog lub twj tso kua mis. Txoj kev lis ntshav yog hloov pauv txhua 48 teev .Thaum txuas lub infusion system, kev cai aseptic tau pom. Thaum muaj qhov qog ntawm hypoglycemic, Txoj kev lis ntshav yog nres kom txog rau thaum rov zoo. Yog tias pheej rov qab lossis qis dua cov piam thaj hauv cov ntshav tau sau tseg, tom qab ntawd nws yog qhov yuav tsum tau qhia rau tus kws kho mob txog qhov no thiab txiav txim siab txo lossis tso tseg qhov insulin infusion. Lub twj tso kua mis tsis ua hauj lwm lossis kev txhaws hauv txoj kev lis ntshav tuaj yeem ua rau nce ntxiv hauv cov piam thaj. Yog tias lub sijhawm ua txhaum cai ntawm kev ua txhaum ntawm kev muab cov tshuaj insulin, koj yuav tsum ua raws li cov lus qhia thiab yog tias tsim nyog, qhia rau tus kws kho mob. Thaum siv lub twj tso kua mis, cov tshuaj Humalog yuav tsum tsis txhob muab sib xyaw nrog lwm cov tshuaj insulins.

Sab nyhuv Humalog:

Kev phiv cuam tshuam nrog cov nyhuv tseem ceeb ntawm cov tshuaj: hypoglycemia. Kev mob ntshav khov ntau heev tuaj yeem ua rau tsis nco qab (hypoglycemic coma) thiab, tshwj tsis yog rau kev tuag.

Kev tsis haum tshuaj: kev tawm tsam ntawm lub cev muaj peev xwm ua tau - liab liab, o lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau ploj hauv ob peb hnub lossis ob peb asthiv), kev tiv thaiv kev tsis haum tshuaj (feem ntau tsis tshua muaj, tab sis muaj dua loj dua) - ua kom khaus, ua pob khaus, mob hlwb, mob taub hau, ua npaws, ua tsis taus pa, txo cov ntshav siab, tachycardia, tawm hws. Cov uas muaj mob hnyav raug neeg lub cev tuaj yeem tas sim neej.

Lwm yam: lipodystrophy ntawm qhov chaw txhaj tshuaj.

Cov tshuaj rau txoj kev siv tshuaj:

Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj.

Siv thaum cev xeeb tub thiab lactation.

Txog rau hnub no, tsis muaj qhov xav tau ntawm Lyspro insulin rau kev xeeb tub lossis kev noj qab haus huv ntawm tus menyuam / tus menyuam tshiab tau pom. Tsis muaj cov kev tshawb fawb nthuav txog kab mob sib kis.

Lub hom phiaj ntawm insulin txoj kev kho mob thaum cev xeeb tub yog tswj hwm cov ntshav qabzib kom txaus rau cov neeg mob ntshav qab zib insulin-los yog mob ntshav qab zib hauv lub ntsej muag. Qhov xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb thaum cev xeeb tub. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov poj niam ntawm lub hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov pib lossis npaj kom cev xeeb tub. Thaum cev xeeb tub, cov neeg mob ntshav qab zib yuav tsum ua tib zoo saib xyuas cov ntshav qabzib, nrog rau kev saib xyuas neeg mob txhua yam.

Hauv cov neeg mob uas mob ntshav qab zib mellitus thaum pub niam mis, yuav tsum tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum.

Cov lus qhia tshwj xeeb rau kev siv Humalog.

Hloov chaw ntawm tus neeg mob mus rau lwm hom lossis hom tshuaj insulin yuav tsum tau ua raws li kev saib xyuas mob nkeeg nruj me ntsis. Cov kev hloov hauv kev ua, hom (tsim tawm), hom (piv txwv, tsis tu ncua, NPH, Daim kab xev), hom (tsiaj, tib neeg, tib neeg insulin analogue) thiab / lossis cov qauv kev tsim tawm (DNA recombinant insulin lossis insulin ntawm keeb kwm tsiaj) yuav xav tau hloov pauv cov koob tshuaj.

Kev mob uas cov cim qhia ntxov ntawm hypoglycemia yog qhov tsis tseem ceeb thiab tsis tshua hais tawm muaj xws li txuas ntxiv cov ntshav qab zib mellitus, kev kho mob insulin ntau ntxiv, kab mob hauv cov kab mob ntshav qab zib mellitus, lossis tshuaj noj, xws li beta-blockers.

Hauv cov neeg mob hypoglycemic tshua tom qab hloov los ntawm tsiaj los ntawm cov tshuaj insulin rau tib neeg insulin, cov tsos mob thaum ntxov ntawm hypoglycemia yuav tsis tshua pom los yog txawv ntawm cov kev paub dhau los ntawm lawv cov insulin yav dhau los. Kev tswj tsis tau tus mob hypoglycemic lossis hyperglycemic tshua tuaj yeem ua rau tsis nco qab, tsis nco qab, lossis tuag.

Kev noj tshuaj tsis txaus lossis tsis ua haujlwm ntawm kev kho mob, tshwj xeeb tshaj yog muaj cov kab mob ntshav qab zib insulin-tuaj yeem ua rau hyperglycemia thiab ntshav qab zib ketoacidosis, cov xwm txheej uas yuav tsim kev phom sij rau tus neeg mob.

Txoj kev xav tau cov tshuaj insulin tuaj yeem txo cov neeg mob lub raum tsis ua haujlwm, zoo ib yam li cov neeg mob lub siab ua haujlwm vim qhov ua haujlwm tsawg kawg ntawm gluconeogenesis thiab insulin metabolism. Txawm li cas los xij, nyob rau hauv cov neeg mob mob siab tsis ua haujlwm ntev, muaj peev xwm tiv thaiv insulin ntau dua tuaj yeem ua rau muaj kev nce ntxiv hauv insulin.

Qhov xav tau ntawm cov tshuaj insulin tuaj yeem nce nrog cov kis kab mob, kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov carbohydrates hauv cov zaub mov noj.

Yog hais tias tus neeg mob lub cev qoj ib ce ntau zog los yog pauv noj zaub mov zoo ces kuj tseem yuav tsum tau txhaj koob tshuaj. Kev tawm dag zog tam sim ntawd tom qab noj mov tas yuav ua rau muaj ntshav qab zib tsawg dua. Ib qhov tshwm sim ntawm lub pharmacodynamics ntawm kev ua yeeb yam sai sai ntawm insulin analogues yog tias yog tias cov ntshav qog ntshav qab zib, tom qab ntawd nws tuaj yeem txhim kho tom qab txhaj tshuaj dua li thaum txhaj cov tshuaj tiv thaiv tib neeg cov tshuaj insulin.

Tus neeg mob yuav tsum tau ceeb toom tias yog tias tus kws kho mob tau sau ib qho tshuaj insulin nrog rau 40 IU / ml hauv lub vial, ces cov tshuaj insulin yuav tsum tsis txhob los ntawm daim cartridge nrog cov tshuaj insulin ntawm 100 IU / ml nrog koob txhaj rau kev txhaj tshuaj insulin nrog qhov sib luag ntawm 40 IU / ml.

Yog tias nws yuav tsum tau noj lwm cov tshuaj tib lub sijhawm uas Humalog, tus neeg mob yuav tsum sab laj nrog kws kho mob.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Nrog hypoglycemia lossis hyperglycemia cuam tshuam nrog kev noj tshuaj tsis zoo, kev ua txhaum ntawm kev muaj peev xwm mloog zoo thiab qhov ceev ntawm psychomotor cov tshuaj tiv thaiv tuaj yeem tau. Qhov no tuaj yeem dhau los ua kev pheej hmoo rau cov haujlwm muaj kev phom sij (suav nrog kev tsav tsheb lossis kev ua haujlwm nrog cov tshuab).

Cov neeg mob yuav tsum tau ceev faj kom tsis txhob muaj hypolycemia thaum tsav tsheb. Qhov no tseem ceeb tshwj xeeb tshaj yog rau cov neeg mob uas muaj qhov txo qis los yog tsis hnov ​​qhov zoo ntawm cov tsos mob ua ntej rau tus mob ntshav qab zib tsawg, los yog leej twg muaj qee yam cov ntshav qog ntshav qis. Hauv cov xwm txheej no, nws yog qhov yuav tsum tau los ntsuas qhov ua tau ntawm kev tsav tsheb. Cov neeg mob ntshav qab zib muaj peev xwm tiv thaiv nws tus kheej los ntawm kev muaj ntshav qabzib tsawg tsawg los ntawm kev noj ntshav qabzib lossis zaub mov ntau hauv carbohydrates (Nws raug nquahu kom koj ib txwm muaj tsawg kawg 20 g piam thaj nrog koj). Tus neeg mob yuav tsum qhia tus kws kho mob uas koom nrog paub txog qhov hloov pauv hypoglycemia.

Kev siv tshuaj ntau dhau:

Cov tsos mob: hypoglycemia, nrog rau cov tsos mob hauv qab no: qaug zog, tawm hws ntau, mob tachycardia, mob taub hau, ntuav, tsis meej pem.

Kev Kho Mob: Cov mob ntshav qab zib tsawg kawg feem ntau yuav nres los ntawm kev noj cov piam thaj lossis lwm yam piam thaj, lossis cov khoom muaj suab thaj.

Kev kho cov ntshav qog ntshav me ntsis tuaj yeem nqa nrog kev pab los ntawm a / m lossis s / c tswj hwm ntawm glucagon, tom qab ntawd kev noj zaub mov carbohydrates tom qab kev tswj hwm tus neeg mob lub cev. Cov neeg mob uas tsis teb rau glucagon raug muab iv dextrose (glucose) tov.

Yog tias tus neeg mob tsis nco qab, tom qab ntawd glucagon yuav tsum tau txhaj rau hauv / m lossis s / c. Thaum tsis muaj cov glucagon los sis yog tias tsis muaj tshuaj tiv thaiv rau nws txoj kev tswj hwm, nws yog qhov tsim nyog los qhia qhov kev daws teeb meem ntawm cov tshuaj tov ua kua (glucose). Tam sim ntawd tom qab rov qab nco qab, tus neeg mob yuav tsum tau txais cov zaub mov muaj carbohydrate-nplua nuj.

Ntxiv rau kev txhawb nqa cov carbohydrate kom tsawg thiab kev tshuaj xyuas cov neeg mob tej zaum yuav tsum ua, raws li Ib qho kev rov qab los ntawm hypoglycemia yog ua tau.

Humalog sib cuam tshuam nrog lwm yam tshuaj.

Cov nyhuv hypoglycemic yog txo los ntawm kev tiv thaiv qhov ncauj, corticosteroids, thyroid hormone npaj, danazol, beta2-adrenergic agonists (suav nrog rhytodrin, salbutamol, terbutaline), tricyclic antidepressants, thiazide diuretics, chlorprotixenic acid, niacin, diazid derivatives ntawm phenothiazine.

Cov nyhuv hypoglycemic ntawm Humalog yog txhim kho los ntawm beta-blockers, ethanol thiab ethanol-muaj cov tshuaj, anabolic steroids, fenfluramine, guanethidine, tetracyclines, tshuaj tiv thaiv hypoglycemic, salicylates (piv txwv li, acetylsalicylic acid, aniloprilactyl antagonists, MAP inhibitors, Ml. angiotensin II cov neeg txais.

Cov tshuaj tiv thaiv yuav tsum tsis txhob xyaw nrog tsiaj cov tshuaj insulin.

Siv tau cov tshuaj Humalog (nyob rau hauv kev saib xyuas ntawm tus kws kho mob) ua ke nrog kev ua haujlwm ntev ntawm tib neeg cov kua dej los yog ua ke nrog cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, sulfonylurea derivatives.

Cov lus pom zoo muag hauv chaw muag tshuaj.

Cov tshuaj yog ntawv yuav tshuaj.

Cov lus pom zoo cia ntawm cov tshuaj Humalog.

Sau npe B. Cov tshuaj yuav tsum muab cia kom ncav tsis cuag ntawm cov menyuam yaus, hauv lub tub yees, ntawm qhov txias li 2 ° txog 8 ° C, tsis txhob cia kom khov. Txee lub neej yog 2 xyoos.

Cov tshuaj yeeb hauv kev siv yuav tsum khaws cia hauv chav sov li ntawm 15 ° txog 25 ° C, tiv thaiv los ntawm tshav ntuj ncaj qha thiab kub. Txee lub neej - tsis pub dhau 28 hnub.

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb Neej Neeg Cov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Humalog hauv lawv cov kev coj ua.Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov Txiaj Ntsig ntawm Humalog nyob rau hauv muaj cov qauv txheej txheem qauv. Siv rau kev kho mob ntawm hom 1 thiab hom 2 mob ntshav qab zib mellitus (ntshav qab zib-insulin thiab tsis-insulin-mob ntshav qab zib) rau cov neeg laus, menyuam, nrog rau lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Neej Neeg - cov duab ntawm cov tshuaj insulin, txawv ntawm nws los ntawm kev rov qab ua ntu zus ntawm cov kab sib luag thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Piv nrog luv luv ua yeeb yam npaj cov tshuaj insulin, lyspro insulin yog tus yam ntxwv sai dua ntawm qhov pib thiab qhov kawg ntawm cov nyhuv, uas yog vim muaj kev nqus ntxiv los ntawm subcutaneous depot vim yog kev txuag ntawm monomeric qauv ntawm lyspro insulin lwg me me hauv cov tshuaj. Qhov pib ntawm kev ua yog 15 feeb tom qab tswj hwm subcutaneous, qhov ua haujlwm siab tshaj plaws yog nruab nrab ntawm 0.5 teev thiab 2.5 teev, lub sijhawm ua ntawm 3-4 teev.

Humalog Mix yog DNA - muab cov kab mob tshiab ntawm tib neeg cov kua dej thiab yog qhov sib xyaw ua ke uas muaj lyspro insulin tov (kev ua kom sai ntawm tib neeg cov kua dej) thiab kev ncua ntawm lyspro protamine insulin (nruab nrab ntev tib neeg cov tshuaj insulin).

Kev ua tseem ceeb ntawm insulin lyspro yog kev cai ntawm cov metabolism hauv cov piam thaj. Ntxiv rau, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Lyspro insulin + excipients.

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), qhov koob tshuaj (ntim ntawm txhaj tshuaj insulin), thiab qhov tob ntawm cov tshuaj insulin hauv kev npaj. Nws tau faib tawm tsis ncaj hauv daim ntaub. Nws tsis hla tus cwj pwm ntawm lub tso mis thiab nkag rau hauv niam mis. Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum - 30-80%.

• yam 1 mob ntshav qab zib mellitus (insulin-dependant), suav nrog nrog kev tsis nkag siab rau lwm txoj kev npaj tshuaj insulin, nrog postprandial hyperglycemia uas tsis tuaj yeem kho los ntawm lwm yam kev npaj tshuaj insulin, mob subcutaneous insulin tsis kam (nrawm hauv lub zos insulin degradation),
• hom 2 mob ntshav qab zib mellitus (non-insulin-dependant): nrog kev tawm tsam cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, nrog rau kev nqus tsis tau ntawm lwm yam tshuaj insulin, kev tiv thaiv tsis tau tom qab hyperglycemia, thaum lub sijhawm ua haujlwm, cov kabmob sib kis.

Ib qho kev daws teeb meem rau kev tswj hwm kom haum thiab subcutaneous ntawm 100 IU hauv 3 ml cartridge sib xyaw rau hauv QuickPen cwj mem los yog cwj mem kua txho.

Ncua rau kev rho tawm ntawm 100 IU hauv 3 ml cartridge sib xyaw rau hauv QuickPen cwj mem los yog cwj mem kua (Humalog Mix 25 thiab 50).

Lwm cov ntaub ntawv ntau npaum li cas, tsis pub muaj ntsiav tshuaj lossis tsiav tshuaj, tsis muaj nyob.

Cov lus qhia rau kev siv thiab qauv ntawm kev siv

Dosage yog teeb tsa ib tus zuj zus. Lyspro insulin yog muab tshuaj subcutaneously, intramuscularly lossis intravenously 5-15 feeb ua ntej noj mov. Ib koob tshuaj yog 40 units, ntau dhau tsuas tso cai tshwj xeeb. Nrog rau cov tshuaj tua kab mob, Lyspro insulin muab rau 4-6 zaug hauv ib hnub, ua ke nrog kev npaj tshuaj insulin ntev - 3 zaug hauv ib hnub.

Cov tshuaj yuav tsum tau muab tshuaj subcutaneously.

Tso dej siab tswj hwm ntawm cov tshuaj Humalog Mix yog contraindicated.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov.

Subcutaneously yuav tsum txhaj rau hauv lub xub pwg, ncej puab, pob tw los sis plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj 1 zaug hauv ib hlis.Thaum s / qhia txog cov tshuaj Humalog, yuav tsum saib xyuas kom tsis txhob txais cov tshuaj rau hauv cov hlab ntsha. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.

Thaum txhim kho lub taub hau hauv lub twj txhaj tshuaj insulin thiab txuas lub koob ua ntej insulin thawj coj, cov lus qhia ntawm cov chaw tsim khoom ntawm cov cuab yeej siv tshuaj insulin yuav tsum ua raws cai.

Cov kev cai rau kev qhia ntawm cov tshuaj Humalog Mix

Npaj rau kev qhia

Tam sim ntawd ua ntej siv, Humalog Mix sib xyaw cartridge yuav tsum tau muab sib dhos ntawm xib teg kaum npaug thiab tshee, tig ntawm 180 ° kuj kaum zaus kom rov kho cov tshuaj insulin kom txog thaum nws zoo li homogeneous huab lossis kua mis. Tsis txhob co khov kho, raws li qhov no tuaj yeem ua rau npuas dej, uas tuaj yeem cuam tshuam nrog cov koob tshuaj kom raug. Txhawm rau kom yooj yim rau kev sib xyaw, lub pob txha taub ntawv muaj lub khob iav me me. Cov tshuaj yuav tsum tsis txhob siv yog tias nws muaj plaub yaig tom qab tov.

Yuav siv cov tshuaj li cas

1. Ntxuav tes.
2. Xaiv ib qho chaw rau kev txhaj tshuaj.
3. Kho cov tawv nqaij nrog tshuaj tua kab mob ntawm qhov chaw txhaj tshuaj (nrog rau kev coj tus kheej, raws li tus kws kho mob cov lus pom zoo).
4. Tshem lub hau tiv thaiv sab nraud ntawm rab koob.
5. Txhim kho cov tawv nqaij los ntawm rub nws los yog khi cov quav loj.
6. Ntxig lub koob txhaj tshuaj subcutaneously thiab ua qhov kev txhaj tshuaj raws li cov lus qhia siv kev siv tus xaum xim.
7. Tshem tawm rab koob thiab maj mam muab nyem qhov chaw txhaj tshuaj rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.
8. Siv lub hau sab tiv thaiv ntawm rab koob, unscrew lub koob thiab rhuav tshem nws.
9. Tso lub hau rau ntawm tus cwj mem xaum qhuav.

• hypoglycemia (mob ntshav qab zib heev tuaj yeem ua rau tsis nco qab thiab, tshwj tsis yog mob tuag,),
• liab, o, lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau ploj hauv ob peb hnub lossis limtiam, qee qhov xwm txheej no tuaj yeem yog vim los ntawm tsis muaj feem cuam tshuam nrog insulin, piv txwv li, voos tawv nqaij los ntawm kev siv tshuaj tua kab mob los yog kev txhaj tshuaj tsis zoo),
• dav khaus
• ua pa nyuaj
• txog siav
• txo hauv cov ntshav siab,
• tachycardia
• nce hws
• kev txhim kho ntawm lipodystrophy ntawm thaj chaw txhaj tshuaj.

• ntshav qab zib,
• ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Txog hnub, tsis muaj qhov xav tau ntawm Lyspro insulin rau kev xeeb tub lossis qhov xwm txheej ntawm tus menyuam hauv plab thiab cov menyuam tshiab tau pom.

Lub hom phiaj ntawm kev kho tshuaj insulin thaum cev xeeb tub yog kom tswj tau cov piam thaj kom txaus. Qhov xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb thaum cev xeeb tub. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov poj niam ntawm lub hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov pib lossis npaj kom cev xeeb tub.

Hauv cov neeg mob uas mob ntshav qab zib mellitus thaum pub niam mis, yuav tsum tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum.

Cov kab ke ntawm cov thawj coj npaj rau kev siv ntau npaum ntawm lyspro insulin yuav tsum nruj me ntsis. Thaum hloov cov neeg mob los ntawm kev ua yeeb yam sai sai insulin npaj cov tsiaj keeb kwm rau insulin lispro, yuav tsum tau txhaj koob tshuaj. Kev hloov chaw ntawm cov neeg mob tau txais cov tshuaj insulin nyob rau hauv ib hnub ntau dua 100 units los ntawm ib hom tshuaj insulin mus rau lwm qhov tau pom zoo kom nqa tawm hauv tsev kho mob.

Kev xav tau rau cov tshuaj insulin tuaj yeem nce ntxiv thaum kis kab mob, nrog kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov khoom noj carbohydrates hauv cov zaub mov, thaum ntxiv kev noj tshuaj ntxiv nrog hyperglycemic kev ua si (cov thyroid hormones, glucocorticoids, qhov ncauj tiv thaiv, thiazide diuretics).

Qhov xav tau ntawm cov tshuaj insulin yuav txo qis nrog lub raum thiab / lossis lub siab ua haujlwm, nrog qhov kev txiav txim siab ntawm cov khoom noj carbohydrates hauv zaub mov, nrog kev tawm dag zog lub cev, thaum ntxiv kev noj tshuaj nrog hypoglycemic kev ua si (MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides).

Kev kho cov ntshav qog ntshav qab zib hauv qhov mob hnyav tuaj yeem nqa tawm los ntawm kev siv i / m thiab / lossis s / c tswj hwm ntawm glucagon lossis iv kev tswj xyuas ntshav qabzib.

Cov nyhuv hypoglycemic ntawm Lyspro insulin yog txhim kho los ntawm MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides, acarbose, ethanol (cawv) thiab tshuaj uas muaj ethanol.

Cov nyhuv hypoglycemic ntawm Lyspro insulin yog txo los ntawm glucocorticosteroids (GCS), cov thyroid hormones, tshuaj tiv thaiv qhov ncauj, thiazide diuretics, diazoxide, tricyclic antidepressants.

Beta-blockers, clonidine, reserpine tuaj yeem npog qhov tsos ntawm cov tsos mob ntawm qog ntshav qab zib.

Cov tshuaj ntawm cov tshuaj Humalog

Cov qauv ntawm cov qauv ua haujlwm:

• Lyspro insulin
• Humalog Mix 25,
• Neej Neeg Qhia 50.

Cov cim qhia hauv pawg pharmacological (insulins):

• Tus kws kho mob HM Penfill,
• Actrapid MS,
• B-Insulin S.Ts. Berlin Chemie,
• Berlinsulin H 30/70 U-40,
• Berlinsulin H 30/70 cwj mem,
• Berlinsulin N Basal U-40,
• Berlinsulin N Basal Cwj mem,
• Berlinsulin Hom U-40,
• Berlinsulin N Tus Cwj Pwm Zoo Li Cas,
• Qov tshuaj insulin C,
• Isofan Insulin Ntiaj Teb Khob,
• Iletin
• Insulin Daim Kab Xev SPP,
• Tshuaj insulin
• Nqaij npuas ua kua txig ntau dhau los ua tiav MK,
• Insuman Zuag,
• Rau Sab Kev SPP,
• Intral Ntiaj Teb Khob,
• Combinsulin C
• Mikstard 30 NM Penfill,
• Monosuinsulin MK,
• Monotard
• Pensulin,
• Protafan HM Penfill,
• Protafan MS,
• Rinsulin
• Ultratard NM,
• Homolong 40,
• Hom 40,
• Neeg lim hiam.

Thaum tsis muaj cov tshuaj analogues rau cov tshuaj rau cov tshuaj yeeb dej caw, koj tuaj yeem nyem rau ntawm qhov txuas hauv qab no rau cov kab mob uas cov tshuaj tsim nyog pab los ntawm thiab pom muaj cov analogues rau kev kho mob nyhuv.

Humalog: cov lus qhia rau kev siv

1 ml muaj:

cov tshuaj nquag: insulin lispro 100 IU / ml,

kev zam: glycerol (glycerin), zinc oxide, sodium hydrogen phosphate heptahydrate, metacresol, dej rau txhaj, hydrochloric acid daws 10% thiab sodium hydroxide tov 10% los tsim pH.

Pharmacological kev txiav txim

Kev ua tseem ceeb ntawm insulin lyspro yog kev cai ntawm cov metabolism hauv cov piam thaj.

Tsis tas li ntawd, insulins muaj cov teebmeem sib txawv anabolic thiab anti-catabolic rau ntau cov ntaub so ntswg. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Lyspro insulin yog tus cwj pwm los ntawm qhov pib sai ntawm kev nqis tes ua (kwv yees li 15 feeb), uas tso cai rau nws ua sai sai ua ntej noj mov (0-15 feeb ua ntej noj mov), tsis zoo li cov insulin tsis tu ncua (30-45 feeb ua ntej noj mov). Kev ua ntawm insulin lyspro yog tus cwj pwm los ntawm qhov pib sai, nws muaj lub sijhawm luv luv ntawm kev coj ua (ntawm 2 txog 5 teev) piv nrog cov tshuaj insulin.

Cov kev tshawb fawb soj ntsuam ua rau cov neeg mob uas muaj hom 1 thiab hom 2 mob ntshav qab zib mellitus tau pom tias nrog insulin lyspro, postprandial hyperglycemia txo qis dua piv rau tib neeg cov kua dej.

Ib yam li txhua qhov kev npaj tshuaj insulin, lub sijhawm ua haujlwm ntawm lyspro insulin ua haujlwm tuaj yeem sib txawv hauv cov neeg mob lossis sijhawm sib txawv ntawm tib tus neeg mob thiab nyob ntawm lub koob tshuaj, chaw txhaj tshuaj, ntshav ntshav, lub cev kub thiab lub cev.

Cov chaw kuaj mob tau ua nrog cov menyuam yaus (61 tus neeg laus hnub nyoog 2 txog 11 xyoos), nrog rau cov menyuam yaus thiab cov hluas (481 tus neeg laus hnub nyoog 9 txog 19 xyoos), uas piv rau insulin lispro thiab solulin tib neeg cov kua dej.Cov yam ntxwv ntawm lyspro insulin hauv cov menyuam yaus zoo ib yam li cov laus.

Thaum siv nyob rau hauv lub twj tso kua mis insulin, ntau dua qhov txo qis hauv qib ntawm glycosylated hemoglobin tau pom thaum kho kho nrog lispro insulin piv rau kev kho mob nrog soluble tib neeg cov insulin. Hauv kev tshawb nrhiav qhov muag pom ob zaug, qhov kev txo qis glycosylated hemoglobin tom qab 12 lub lis piam ntawm kev kho mob yog 0.37% hauv lisproin insulin pab pawg piv nrog 0.03% hauv pawg solulin neeg insulin (p = 0.004).

Hauv cov neeg mob uas muaj ntshav qab zib hom 2 tau txais cov tshuaj sulfonylurea ntau tshaj plaws, qhov ntxiv ntawm lyspro insulin ua rau muaj qhov txo qis hauv glycosylated hemoglobin ntau ntau. Txo cov qib HbAic yuav tsum tau cia siab nrog lwm cov tshuaj insulin, xws li soluble lossis NPH.

Cov kev tshawb fawb pom tau hais tias kev kho mob insulin nrog lyspro cov neeg mob ntshav qab zib mellitus hom 1 thiab 2 yog nrog los txo qis ntawm cov kev mob tshwm sim ntawm nocturnal hypoglycemia piv nrog insulins tib neeg cov tshuaj lom neeg. Hauv qee qhov kev tshawb fawb, qhov kev txo qis ntawm cov kev mob qog ntawm nocturnal hypoglycemia tau cuam tshuam nrog kev nce ntxiv ntawm lub sijhawm thaum lub sijhawm mob ntshav qab zib tsawg.

Glucodynamic lo lus teb rau lyspro insulin yog ywj pheej ntawm lub raum lossis mob rau cov hlab siab mob hlwb. Qhov sib txawv ntawm glucodynamics ntawm insulin lispro thiab solulin tib neeg cov kua dej tau thaum lub sijhawm euglycemic hyperinsulinemic clamp kuaj tau txais kev txhawb nqa nyob rau hauv kev ua haujlwm ntau ntawm lub raum. Lyspro insulin tau pom tias muaj kev sib npaug ntawm tib neeg cov insulin, tab sis nws cov kev ua yog sai dua thiab kav rau lub sijhawm luv.

Cov Tshuaj Pharmacokinetics

Hauv cov neeg mob uas lub raum tsis ua haujlwm, ntau dua qhov feem ntau ntawm kev nqus ntawm lyspro insulin yog kev saib xyuas piv rau kev txhim kho tib neeg lub cev. Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, pharmacokinetic sib txawv ntawm lispro insulin thiab soluble tib neeg insulin raug tswj dhau ntau cov kev ua haujlwm hauv lub raum, tsis hais txog lub raum. Hauv cov neeg mob uas muaj daim siab tsis txaus, tus nqi ntau dua ntawm kev nqus thiab tshem tawm ntawm lyspro insulin yog tswj piv rau cov neeg muaj peev xwm insulin.

Kev ntsuas rau siv

Kev kho mob ntawm cov neeg mob ntshav qab zib uas xav tau cov tshuaj insulin los pab tswj cov piam thaj hauv lub cev. Humalog® tseem qhia txog kev pib khov kho mob ntshav qab zib.

Cov Yuav Tsum Muaj

Hypersensitivity rau insulin lyspro lossis qee yam ntawm cov tshuaj. Kev ntshav siab.

Cev xeeb tub thiab lactation

Cov ntaub ntawv los ntawm coob tus neeg siv cev xeeb tub tsis tau qhia txog qhov tsis xav tau ntawm insulin lispro ntawm kev xeeb tub lossis kev noj qab haus huv ntawm tus menyuam / tus menyuam tshiab.

Lub hom phiaj ntawm insulin txoj kev kho mob thaum cev xeeb tub yog tswj hwm tus neeg mob ntshav qab zib tau txaus los yog mob ntshav qab zib hauv lub cev. Qhov xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb thaum cev xeeb tub. Cov poj niam ntawm lub hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov pib lossis npaj kom cev xeeb tub. Thaum cev xeeb tub, cov neeg mob ntshav qab zib yuav tsum ua tib zoo saib xyuas cov ntshav qabzib, nrog rau kev saib xyuas neeg mob txhua yam.

Rau cov neeg mob ntshav qab zib, yuav tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum lub sijhawm pub niam mis.