Torvacard "lossis" Atorvastatin "

Peb cov neeg nyeem tau siv Aterol ua tiav kom qis cov roj (cholesterol). Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Torvacard yog ib qho tshuaj yeeb statin. Raws li cov khoom xyaw ua haujlwm, cov tshuaj Torvacard muaj Atorvastatin, uas muaj cov roj (cholesterol) txo qis. Cov tshuaj yog tsim los ntawm Czech lub tuam txhab "Zentiva" nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj muaj 10, 20 thiab 40 mg. Atorvastatin ua rau cov ntshav lipoproteins zoo thiab plasma ntshav tsawg.

• Cov Khoom Qhia
• Cov Khoom Noj Muaj Roj Ntshav Qab Zib
• Cov cai tswj kev sau tshuaj
• Thaum twg koj yuav tsum tsis txhob siv Torvacard?
• Thorvacard thaum cev xeeb tub thiab lactation
• Yuav ua li cas noj Torvacard?
• Tshwj xeeb cov kev phom sij phom sij
• Qee qhov taw qhia rau kev kho mob statin
• Torvacard analogues thiab tus nqi ntawm cov tshuaj

1. Tawm tsam keeb kwm yav dhau los ntawm kev noj cov zaub mov hypocholesterol nrog cov kev txiav txim siab hauv cov ntshav los ua kom cov cholesterol, sib xyaw hypercholesterolemia.
2. Nrog rau qhov nce hauv cov ntshav cov kwv yees ntawm triglycerides thiab dibetalipoproteinemia.
3. Mob vascular thiab mob plawv hauv cov neeg mob uas muaj kev pheej hmoo loj ntawm kev tsim muaj cov ischemic hnyav - lub hnub nyoog tom qab 55 xyoo, cov kab mob endocrine, kab mob viav vias.
4. Hauv kev tiv thaiv ntawm cov teeb meem thib ob tom qab mob ceev ischemic.

Atorvastatin

Cov tshuaj yog statin thiab tsom rau cov roj (cholesterol) tsawgCov. Muag hauv cov khw muag tshuaj hauv cov qauv tshuaj. Cov nkauj muaj lub ntsiab ua haujlwm tseem ceeb atorvastatin hauv qhov npaum li cas 10 lossis 20 mg rau ib ntsiav tshuaj. Ntxiv rau, muaj cov pabcuam ntawm cov calcium stearate, opadra, hmoov txhuv nplej siab, cellulose, calcium carbonate thiab lactose.

Cov twj yog qhia rau cov kab mob hauv qab no:

• Yuav kom txo qis cov roj cholesterol.
• Hauv rooj plaub thaum kev noj tshuaj pab tsis tuaj yeem pab.
• Rau kev kho mob ua ke nrog kev kho mob noj.

Muaj ib tug xov tooj ntawm contraindications nyob rau hauv uas koj tsis tuaj yeem noj cov tshuaj no. Ntawm lawv yog:

1. Cov me nyuam qis dua 18 xyoo.
2. Cev xeeb tub thiab pub niam mis.
3. Cov poj niam tsis noj tshuaj txwv tsis pub muaj menyuam thaum nws muaj hnub nyoog deev.
4. Cov kev mob nyhav ntawm daim siab thiab lub raum.
5. Lactase tsis muaj zog.
6. Raus mus rau cheebtsam.

Nrog rau kev ceev faj, cov kws kho mob tau sau tshuaj rau kev phais mob hnyav thiab thaum rov kho dua, rau kev raug mob, mob plab, mob ntshav qab zib mellitus thiab qee cov kab mob thyroid.

Qee cov neeg mob qhia txog kev tshwm sim ntawm kev mob tshwm sim. Cov no suav nrog:

• Qhov hnyav nce.
• Aggravation ntawm gout.
• Kev ua xua tsis haum.
• Kev ntshav siab.
• Tsis tshua muaj siab kev sib deev, impotence.
• Ntshav.
• Kab mob ntawm cov leeg thiab pob qij txha.
• Cramps.
• Cov pos hniav los ntshav.
• Kev quav dej, mob plab, kub siab, xeev siab.
• Mob Kev Plab
• Ua txhaum ntawm saj.
• Mob taub hau thiab kiv taub hau.

Cov kws kho mob sau tseg tias thaum muaj kev mob tshwm sim, muaj qhov ntxim nyiam ntawm lawv txoj kev ua kom muaj zog ntxiv, yog li qee zaum lawv txo qhov ntau npaum li cas, lossis sau ntawv coj mus kho txawv.

Cov tshuaj yog raug faib tawm los ntawm cov tshuaj noj. Kwv yees tus nqi hauv cov khw muag tshuaj yog txog 150 rubles rau ib pob ntawm 10 mg.

Dab tsi yog qhov sib txawv ntawm cov tshuaj

Cov tshuaj yog txhawm rau kho tib qho teeb meem, muaj tib lub cev nquag. Txawm li cas los xij, atorvastatin raug muag hauv hom 10 lossis 20 mg rau ib ntsiav tshuaj, thiab Torvacard tuaj yeem pom ntawm muag hauv 10, 20 lossis 40 mg.

Lawv cov nqi sib txawv me ntsis. Torvacard tseem kim dua, txog 300 rubles rau 10 mg. Atorvastatin pheej yig dua - txog 150 rubles rau ib yam tshuaj.

Qhov twg zoo dua rau kev xaiv

Cov kws kho mob feem ntau sau ntawv rau ib lossis lwm yam tshuaj raws kev paub ntawm tus kheej.Yog tias ib tus neeg ua ntej dhau los muaj qhov tsis zoo thaum lub sijhawm noj ib qho lossis lwm yam tshuaj, ces nws tsis raug muab tshuaj ntxiv.

Feem ntau, ob qho tshuaj puav leej zoo sib xws hauv kev nqis tes ua thiab cov tshuaj yeeb dej caw, yog li ntawd Nws tsis muaj ntau qhov sib txawv uas yuav ib qho, tsis muajCov. Feem ntau, cov neeg mob tau coj los ntawm qhov muaj ntawm cov tshuaj ntawm lub tsev muag tshuaj tam sim no. Yog tias ib qho ntawm lawv tsis yog, tom qab ntawd koj tuaj yeem hloov nws nrog lwm tus. Txawm li cas los xij, yog tias tus neeg xav hloov cov tshuaj thaum kho, ces koj yuav tsum sab laj nrog kws kho mob.

Atoris: lus piav qhia, muaj pes tsawg leeg, thov

Cov tuam txhab muag tshuaj muaj ntau cov tshuaj tawm los tawm tsam atherosclerosis thiab cov muaj roj hauv siab. Yuav xaiv cov txiaj ntsig zoo tshaj plaws thiab nyab xeeb npaum li cas?

Atoris, tshuaj uas txo qis roj hauv lub cev, tseem nrov heev. Nws zwm rau pab pawg ntawm statins. Cov tshuaj muaj nqis yog atorvastatin. Nws inhibits cov synthesis ntawm cov cholesterol los ntawm kev ua kom tsis muaj zog ntawm enzyme HMG CoA reductase, pab txo nws cov qib hauv cov ntshav. Nws txo qis cov lipoproteins tsawg ntawm LDL cov roj cholesterol ua teeb meem rau tib neeg, thiab rov ua dua, nce qhov nce ntawm HDL, txhawb nws cov anti-atherosclerosis. Cov tshuaj nquag Atorvastatin txo cov kev saib xyuas ntawm cov tshuaj uas tsim cov peev txheej ntawm adipose nqaij hauv lub cev.

Atoris rau cov statins txog koob thib 3, uas yog, nws ua tau zoo heev.

Muaj nyob rau hauv cov ntsiav tshuaj ntawm 10, 20, 30, 60 thiab 80 ml los ntawm lub tuam txhab Slovenian pharmacological KRKA.
Atoris pom zoo rau kev siv cov neeg mob atherosclerosis thiab cov neeg mob uas muaj lub siab xav ntawm cov roj cholesterol hauv cov ntshav.

Thaum pib, cov tshuaj tau tsim los ua cov khoom lag luam zoo dua ntawm cov khoom kim heev thiab tshawb nrhiav Liprimar cov khoom lag luam tsim los ntawm lub tuam txhab German Pfizer. Tab sis, ua tsaug rau qhov kev ua tau zoo, nws nyob hauv nws lub niche ntawm cov chaw muag tshuaj ntau lawm ntawm statins.

Hloov chaw Atoris

Txhua yam analogues muaj atorvastatin yog cov tshuaj tseem ceeb.

• Liprimar - Pfizer, Lub Tebchaws Yelemees.

Koom tes hauv ntau cov kev sim tshuaj. Nws tau pov thawj nws tus kheej los ua cov khoom siv nyab xeeb thiab siv tau zoo. Muaj tus nqi siab.

• Torvacard - Zentiva, Slovenia.

Muaj pes tsawg leeg zoo tib yam rau Atoris. Nrov hauv cov neeg mob hauv tebchaws Russia.

• Atorvastatin - ZAO Biocom, Alsi Pharma, Vertex - tag nrho cov chaw tsim khoom Lavxias. Cov tshuaj yog nrov heev nyob rau hauv Russia vim tias tus nqi tsawg.

Ntau tus neeg mob xav tias: Atoris lossis Atorvastatin, uas yog qhov zoo dua? Lo lus teb rau lo lus nug no yog tsis muaj dab tsi. Cov tshuaj muaj pes tsawg leeg ntawm ob hom tshuaj yog tib yam tshuaj qub. Qhov no ua rau lawv cov kev ua zoo ib yam. Qhov sib txawv ntawm lawv hauv cov tuam txhab thiab lub teb chaws ntawm kev tsim khoom.

• Atomax - Hetero tshuaj muaj cwj ciam, Is Nrias teb. Nws txawv ntawm Atoris nyob ib puag ncig tsuas yog kev kho mob qis ntawm 10-20 mg. Pom zoo rau kev tiv thaiv ntawm atherosclerosis hauv cov neeg laus.
• Ator - CJSC Vector, Russia.

Nthuav hauv tsuas yog ib qho tshuaj - 20 mg. Nws xav tias yuav tsum tau siv ntau cov ntsiav tshuaj kom tau txais qhov koob uas yuav tsum tau ua.

Kev sib piv nrog lwm cov tshuaj nquag

Cov tshuaj sib xyaw cov tshuaj no suav nrog lwm cov statin.

Livazo - Pierre Fabre Recordati, Fabkis, Ltalis.

Crestor - Russia, Great Britain, Tebchaws Yelemees.

Simgal - Czech koom pheej, Ixayees.

Simvastatin - Serbia, Russia.

Tab sis nws yog tsim nyog kom nco ntsoov tias simvastatin yog thawj-lub tshuaj.

Tsab xov xwm muab los ntawm Filzor.ru

Txo cov theem ntawm kev mloog zoo thiab tswj cov ntsuas ntawm lipids, cov roj cholesterol thiab triglycerides hauv cov ntshav, muab tshuaj rau cov tshuaj uas yog qeb ntawm statins. Ib qho piv txwv tseem ceeb yog Atoris thiab Atorvastatin. Ob qho tshuaj muaj cov tshuaj qub qub, ntsiav tshuaj daim ntawv tso tawm. Lawv cov nyhuv kho yog tib yam. Qhov sib txawv tsuas yog nyob hauv cov tuam txhab tshuaj thiab cov nqi.

Tsuas yog tus kws kho mob tau tuaj yeem txiav txim siab seb qhov tshuaj twg zoo dua thiab siv tau zoo rau tus neeg mob - Atoris lossis Atorvastatin.

Atoris tso tawm daim ntawv - cov ntsiav tshuaj-coated ntsiav tshuaj.Lub hauv paus ua haujlwm tseem ceeb yog atorvastatin. Ib qho tshuaj ntsiav muaj 10, 20, 30, 40, 60 thiab 80 mg ntawm cov khoom no. Ntim suav nrog 10, 30, 60 thiab 90 pieces.

Cov tshuaj inhibits kev tsim cov roj cholesterol vim cov kev sib txuas ntawm ib qho enzyme uas txo nws cov concentration hauv cov ntshav ntshav. Qib ntawm lipoproteins ua teeb meem rau lub cev txo qis vim muaj kev cuam tshuam ntawm cov tshuaj nquag ntawm LDL receptors. Hauv qhov xwm txheej no, ntawm qhov tsis sib xws, muaj kev nce siab ntawm cov ntsiab lus siab ntawm lipoproteins (HDL), uas ua rau cov nyhuv los tiv thaiv atherosclerotic. Cov tshuaj pab txo qis cov tshuaj sib txuas uas tsim kom muaj cov rog rog.

Kev taw qhia rau kev siv:

• thawj hyperlipidemia,
• hypercholesterolemia,
• hypertriglyceridemia,
• kev tiv thaiv kab mob hauv lub plawv thiab cov hlab ntsha, tshwj xeeb tshaj yog rau cov neeg muaj kev pheej hmoo (txij li 55 xyoo, muaj cov ntshav qab zib mellitus, ntshav siab, haus luam yeeb cwj pwm, kev mob caj ces),,
• kev tiv thaiv kev cuam tshuam ntawm cov kab mob pathologies ntawm lub plawv thiab cov hlab ntshav, nrog rau mob stroke, lub plawv nres, angina pectoris thiab lwm yam.

Cov ntsiav tshuaj yog npaj rau kev siv ua ntej noj mov lossis tom qab. Thaum xub thawj 10 mg tau sau tseg, tab sis tom qab ntawd ces qhov koob tshuaj tuaj yeem nce ntxiv txog 80 mg. Ua raws li lub txiaj ntsig ntawm kev kho mob. Cov kev hloov pauv tau pom zoo tom qab 2 lub lis piam ntawm kev siv tshuaj.

Contraindications rau siv:

• leeg pathology
• cirrhosis ntawm daim siab
• mob siab hnyav ua haujlwm
• mob siab rau tus mob ntu (tshwj xeeb tshaj yog rau daim siab mob ntawm ntau yam etiologies),
• lactase deficiency, ib tug neeg lactose tsis txaus ntseeg,
• nce ib tug neeg raug rau cov tshuaj thiab cov khoom sib txuas.

Rau cov menyuam hnub nyoog qis dua 18 xyoo, thiab rau cov poj niam thaum lub cev xeeb tub thiab kev pub niam mis, cov khoom lag luam tsis haum. Nrog kev ceev faj, nws yuav tsum tau ua nyob rau hauv cov ntaub ntawv ntawm kev haus dej cawv ntev, ntsha tsis txaus, lub cev ntawm cov kab mob endocrine system thiab cov metabolism, kab mob kis loj, mob vwm, hypotension.

Dab tsi yog ntau

Atorvastatin yog lub hauv paus ua haujlwm tseem ceeb hauv ob qho tshuaj, yog li cov nyhuv pharmacological zoo ib yam. Nws muaj nyob rau hauv cov hauv qab no:

• tej roj ntshav hauv cov ntshav siab,
• txo qis hauv kev nthuav dav ntawm lipoproteins hauv cov ntshav,
• inhibition ntawm kev loj hlob ntau dhau ntawm cov qauv ntawm tes ntawm phab ntsa ntawm cov hlab ntsha,
• nthuav tawm ntawm lumen ntawm cov hlab ntsha,
• txo qis hauv cov ntshav viscosity, kev tsuj ntawm kev ua ntawm qee feem cuam lub luag haujlwm rau nws coagulability,
• nws txo qis qhov uas yuav muaj qhov teeb meem cuam tshuam nrog kab mob rau cov hlab ntshav.

Muab cov txiaj ntsig pharmacological no, ob qho tshuaj statins yog tshuaj rau cov neeg laus lossis laus, thiab ntau tsawg rau cov neeg hluas. Cov kev qhia siv rau hauv Atoris thiab Atorvastatin yuav luag zoo li qub. Cov tshuaj kho tau pom zoo rau ob qho tib si kho thiab prophylactic lub hom phiaj.

Ib qhov tshwj xeeb ntawm ob qho statins yog lub caij lawv siv. Hauv cov theem thaum ntxov, tus kws kho mob tau sau ntawv noj tsawg kawg, tab sis tom qab ntawd nws tuaj yeem nce ntxiv los tswj cov ntshav hauv cov ntshav siab. Lub chav kawm yuav kav ntev, thiab qee zaum tsim nyog siv tshuaj yaj yeeb rau kev siv lub neej. Hauv qhov no, kev ntsuam xyuas qhov ntsuas ntshav tsis zoo yog muaj qee lub sijhawm los ua.

Kev txhim kho cov kev mob tshwm sim hauv Atoris thiab Atorvastatin kuj zoo ib yam vim muaj cov qub txav. Cov no suav nrog qhov cuam tshuam ntawm cov tshuaj rau:

• cov leeg hlab hlwb - mob taub hau, asthenia, teeb meem pw tsaug zog, txob taus, loog ntawm nqua, teeb meem nco,
• kev mob plawv - ua kom qis dua lossis nce ntshav siab, txhawb cov ntshav siab,
• lub plab zom mov - qhov tshwm sim ntawm qhov tsis paub txog qhov mob nyob rau hauv plab thiab sab hauv qab ntawm sab xis, kub siab, xeev siab, ntuav, ntuav, ntxiv roj tsim, hloov ua pa thiab cem quav, qee zaum muaj kab mob siab, cholecystitis, pancreatitis, mob siab,
• mob txeeb zig thiab kev ua me nyuam - lub raum tsis ua hauj lwm, txo hwj chim, libido,
• musculoskeletal system - mob hauv pob qij txha, cov leeg, pob txha, txha nraub qaum,
• hematopoietic system - thrombocytopenia (qee zaum),
• tawv nqaij - ua pob, khaus khaus, tuaj yeem tev vim raug ua xua
• cov khoom hauv nruab siab - cov teeb meem ntawm kev pab, cov teeb meem hnov ​​lus.

Yog tias qhov tsis xav tau tshwm sim vim noj tshuaj Atoris lossis Atorvastatin, ces nws yog qhov tsim nyog kom tsum tsis txhob siv tshuaj thiab mus rau hauv tsev kho mob. Tus kws kho mob cov lus pom zoo yog: kev txo qhov ntau npaum li cas, hloov nrog ib qho analog lossis kev tshem tawm tag nrho ntawm statins.

Dab tsi yog qhov txawv

Qhov sib txawv ntawm Atoris thiab Atorvastatin yog qhov xav tau ntawm cov tshuaj nquag nquag. Cov qub tau muaj qhov ntau tshaj ntawm 10, 20, 30, 40, 60 thiab 80 mg, thaum kawg tom qab tsuas muaj 10 thiab 20 mg. Nrog kev hloov kho ntau dua, Atoris yuav yooj yim dua.

Qhov txawv thib ob yog cov chaw tsim khoom. Atorvastatin yog tsim los ntawm Biocom, Vertex, Alsi Pharma, uas yog, cov tuam txhab Lavxias. Atoris yog ua los ntawm Krka hauv Slovenia.

Uas yog pheej yig dua

Atoris tuaj yeem tau yuav hauv Lavxias ntawm 400-600 rubles rau ib pob nrog 30 ntsiav tshuaj muaj 10 mg ntawm lub ntsiab. Yog tias koj xaiv tib cov tshuaj ntsiav, tab sis nrog qhov kub siab txog 20 mg, tom qab ntawd tus nqi yuav nce mus txog 1000 rubles.

Atorvastatin-teva nyob rau hauv Russia yog muag txog 150 rubles rau ib pob nrog 10 mg ntsiav tshuaj.

Nqe lus piav kev ua

Atorvastatin (Atoris) yog cov khoom siv hluavtaws xaiv 3-hydroxy-3-methylglutaryl coenzyme A inhibitor (HMG-CoA), txwv tsis pub hloov ntawm HMG-CoA rau lub mevalonate sterol precursor. Cov tshuaj txo cov ntsiab lus ntawm cov roj cholesterol nyob rau hauv cov qog hlwb, vim li ntawd, cov lus qhia ntawm LDL receptors (tsawg lipoprotein receptors - "roj" tsis zoo) nce, uas ua rau nce siab thiab catabolism ntawm LDL, thiab LDL hais yog nqus tau. Atorvastatin ua rau muaj qhov txo qis hauv cov roj (cholesterol) tag nrho thiab LDL cov roj (cholesterol). Ntxiv rau, VLDL (cov roj lipoproteins tsawg heev), apolipoprotein B thiab triglycerides kuj tseem txo qis. Atorvastatin txo txoj kev pheej hmoo ntawm ischemic lub sijhawm tsis pub dhau 16 lub lis piam tom qab mob hlab ntsha tawg, nrog rau kev pheej hmoo ntawm cov hlab plawv mob hauv cov neeg mob ntshav siab. 95-99% ntawm cov tshuaj yog nqus tau los ntawm txoj hnyuv hauv plab, uas tawm hauv lub cev los ntawm cov hlwb ntawm cov roj ntsha ntawm lub plab thiab txoj hnyuv. Tom qab thawj zaug dhau mus, qhov tseeb txog kev nyab xeeb yog li 12%, qhov cuam tshuam tiv thaiv kev tiv thaiv tiv thaiv HMG-CoA reductase yog li 30% (kwv yees li 70% ntawm cov haujlwm no yog cov metabolites ntawm Atorvastatin). Lub sijhawm kom mus txog qhov siab tshaj plaws yog 1-2 teev. Kwv yees li 98% ntawm cov tshuaj khi rau cov ntshav plasma. Atorvastatin yog tshuaj tiv thaiv hauv lub siab ua kom cov metabolites nquag. Hauv cov metabolism ntawm cov tshuaj feem ntau CYP3A4 yog koom tes nrog. Ib nrab-lub neej yog 14 teev. Qhov cuam tshuam ntawm HMG-CoA tseem muaj txog 20-30 teev vim muaj cov metabolites. Kwv yees li ntawm 98% ntawm cov tshuaj tawm hauv cov kua tsib. Hauv cov neeg mob uas muaj mob rau daim siab mob ntev, lub chaw muag tshuaj ntawm Atorvastatin hloov pauv ntau (qhov nruab nrab siab tshaj plaws nce txog 16 zaug, thiab thaj chaw hauv qab nkhaus los ntawm 11 npaug). Kev txo qis hauv cov ntshav roj yog saib tau kwv yees li 2 lub lis piam tom qab pib kho, thiab cov txiaj ntsig siab tshwm sim tom qab 4-6 lub lis piam thiab tswj tau thaum kho ntxiv. Thaum koj tsum tsis siv yeeb tshuaj, cov qib roj cholesterol rov qab zoo li qub.

Uas yog qhov zoo dua lypimar lossis torvakard

Hauv seem Kab Mob, Tshuaj kho mob rau nqe lus nug LIPRIMAR zoo dua li TORVACARD yog dab tsi? cov lus teb zoo tshaj plaws tau muab los ntawm tus sau Ignat yog lypimar ntau ntau kim dua li torvacard.

pom tau tias cov neeg sawv cev ntawm cov kws tsim tshuaj ntsiav ua haujlwm zoo nrog cov kws kho mob, yog li lawv sau ntawv tias nws kim dua. coj torvakard - nws tsis muaj zuj zus

Lub hauv paus yog tus kws kho mob nws tus kheej

Torvakard tsim tawm Zentiva - cov no yog peb lub tebchaws socialist yav dhau los, thiab Lypimar yog lub tuam txhab Belgian nrog cov chaw haujlwm hauv Asmeskas thiab Turkey, thiab lwm yam Cov tshuaj yeeb yam hauv cov kev npaj no yog tib yam - atorvastatin. Tsis txhob quav ntsej koj lub taub hau. puas yog torvakard pab koj ?? Yog muaj, ces mam li haus nws. thiab hais txog cawv - yog tias koj haus dej txhua txhua hnub, ces cov lus tim khawv yuav tsis zoo dua. koj tuaj yeem haus, tab sis tsis yog hauv litres, thiab ib khob ntawm cawv txiv ntoo tsis ua rau mob, thiab tsis txhua hnub

Cov lus qhia rau kev siv tshuaj

Muab qhov tseeb hais tias atherosclerosis yog ib qho kab mob tuag taus, nws tsim nyog mus ze rau kev kho mob nrog lub luag haujlwm. Tus qauv kub rau kev kho yog statins.

Tus txheej txheem ntawm lawv cov kev ua yog zoo ib yam rau tag nrho pawg thiab muaj qhov thaiv ntawm HMG-CoA reductase cov enzymes uas coj cov roj cholesterol hauv lub siab.

Thaum siv cov tshuaj tsis tu ncua, cov neeg mob kho qhov sib piv ntawm lipid feem, nrog rau inhibition ntawm cov roj cholesterol, feem tsawg ntawm cov roj ntsha, triglycerides thiab Alipoprotein B. Cov tshuaj no txo ​​cov kev pheej hmoo ntawm kev ua rau tuag taus xws li embolism, mob myocardial infarction, gangrene ntawm qhov kawg, ischemic mob stroke thiab angina pectoris, thawj zaug.

Atorvastatin thiab lwm yam statins yog npaj rau kev siv qhov ncauj. Lawv tsuas yog noj nrog kws kho mob sau, uas yuav ua tib zoo kawm lipid profile ua ntej sau ntawv tawm tswv yim, tawm tswv yim txog kev ua neej thiab kev noj zaub mov zoo, vim tias kev rog dhau hwv ua rau cov nyhuv ntawm cov tshuaj rau cov cholesterol.

Cov koob tshuaj feem ntau raug xaiv rau qhov siab tshaj plaws ntawm cov neeg mob thiab yog nyob hauv ib ntsiav tshuaj, uas noj thaum lub sijhawm twg ntawm hnub, tsis hais noj mov dabtsi. Nws yog ib qho tsim nyog yuav tsum tau tswj cov kev ntsuas ib hlis ib zaug, vim tias thaum tsis muaj qhov ua kom kho tau, qhov tshuaj kho tau kho.

Hauv cov mob muaj mob hnyav, qhov nyiaj ntawd tau nce rau plaub ntsiav tshuaj ib hnub. Hauv cov neeg laus cov neeg mob, qhov noj tsawg kawg yuav tsis hloov kho, vim muaj kev pheej hmoo ntawm lub raum tsis ua haujlwm. Rau cov menyuam yaus, qhov tshuaj yuav tsum tsis pub tshaj nees nkaum milligrams ib hnub. Cov neeg mob muaj kab mob siab, tshuaj yog contraindicated.

Cov kev txhim kho uas tshwm sim muaj qhov tsis zoo, xws li:

• Mob taub hau, pw ntxhov.
• Mob leeg mob, mob ntswj.
• Xeev siab, ntuav, ntsim nyob rau hauv lub qhov ncauj, flatulence, raws plab los yog cem quav.
• Cov tawv nqaij khaus, urticaria.

Nkag mus rau hauv lub plab, lub ntsiav tshuaj yaj sai, nkag mus rau hauv cov ntshav los ntawm cov qog ua kua thiab ntws mus rau qhov chaw ntawm qhov tsis xws luag. Bioavailability yog 12%, dhau los ntawm daim siab, tshem tawm ib nrab-lub neej yog li 15 teev.

Cov neeg mob feem ntau tau tsis meej pem thaum mus yuav ib cov tshuaj, vim tias tus nqi rau cov tshuaj sib txawv, muaj ntau lub teb chaws tsim khoom, muaj ntau ntawm cov npe kev lag luam thiab muaj kev tshaj tawm hauv Is Taws Nem thiab hauv TV.

Tag nrho cov no tsa cov lus nug, dab tsi yog qhov txawv ntawm qhov nplua mais ntawm tshuaj no.

Cov Khoom Noj Muaj Roj Ntshav Qab Zib

Thaum lub sij hawm siv Torvacard, cov kws txawj pom zoo kom soj ntsuam cov zaub mov tshwj xeeb, uas yog tsom rau txo cov roj (cholesterol). Cov kev cai tseem ceeb ntawm kev noj zaub mov roj yog:

• kev txwv ntsev siab tshaj plaws
• cov khoom noj txhua hnub tau muab faib ua 5-6 zaub mov noj,
• kev txwv lossis tsis suav cov tsiaj rog,
• cov hau kev ua noj ua haus kib, haus luam yeeb, ua noj ntawm grill,
• kev ua noj yuav tsum ua los ntawm kev ua noj, muab cub tsis siv roj, muab cub,
• cov khoom noj yuav tsum muaj zaub txaus, txiv hmab txiv ntoo, cereals,
• koj yuav tsum txwv kev siv qe, butter,
• nws yog ib qho tsim nyog kom tshem tawm cov hnyuv ntxwm, tshwj xeeb tshaj yog haus luam yeeb, hnyuv ntxwm, concentrated semi-tiav cov khoom lag luam, cov kaus poom zaub mov, cov khoom noj muaj roj.

Cov zaub mov yuav tsum tsis pub ntau tshaj 2700 calories tauj ib hnub. Ua raws li cov cai khoom noj khoom haus tso cai rau koj los ua kom cov roj cholesterol ib txwm thiab zam ntawm cov teeb meem vascular.Yog tias kev noj zaub mov noj tsis txaus kom txo qis cov roj cholesterol, cov tshuaj statins yog cov tsim tawm.

Cov cai tswj kev sau tshuaj

Yog tias kev kho mob tau kho rau thawj zaug, nws yuav tsum xaiv qhov ntau thiab tsawg ntawm cov tshuaj. Feem ntau, kev kho mob hypocholesterolemia pib nrog kev txhaj tshuaj tsawg kawg ntawm 5 lossis 10 mg ntawm atorvastatin.

Tom qab 3-4 lub lim tiam ntawm kev kho nrog statins, roj thiab lub siab ua haujlwm tau saib xyuas.

Yog tias cov qib roj (cholesterol) nyob hauv lub siab tsis hloov pauv lossis txo qis me ntsis, qhov ntau dua ntawm cov tshuaj tau nce ntxiv. Hauv qhov no, saib xyuas yuav tsum tau them rau kev kuaj kab mob ntawm lub siab.

Thaum twg koj yuav tsum tsis txhob siv Torvacard?

Zoo li feem ntau cov tshuaj statin, Torvacard muaj cov lus contraindications rau kev siv:

1. Kev tsis sib haum xeeb rau ib qho ntawm cov pabcuam lossis cov tshuaj muaj yees.
2. Mob siab cov kab mob ntawm ntau lub hauv paus pib hauv cov theem nquag.
3. Ib qho kev nce qib ntawm daim siab enzymes ntawm cov keeb kwm tsis paub los ntawm ntau dua peb zaug.
4. Kev zov menyuam tsis muaj hnub nyoog hauv cov poj niam uas tsis siv txoj kev tiv thaiv kom ntseeg tau.
5. Lub hnub nyoog txog 18 xyoo.

Cov contraindications hais los saum toj no yog txhua yam, tab sis muaj cov kabmob uas Torvacard tuaj yeem siv tau, tab sis nrog kev ceev faj. Hauv cov lus qhia rau kev siv Torvacard, cov xwm txheej zoo li no tau piav qhia:

• ntshav siab
• kev phais mob hnyav, tshwj xeeb kev phais mob plab,
• kev kis mob dav dav - sepsis,
• musculoskeletal system kab mob
• tsis txaus ntawm dej thiab electrolytes hauv lub cev,
• mob siab yav dhau los
• qaug dab peg thiab lwm yam kab mob nrog rau kev tswj tsis taus chua leeg,
• mob ntshav qab zib mellitus.

Hauv cov xwm txheej no, kev siv Torvacard ntsiav tshuaj pib nrog kev siv tshuaj tsawg kawg nkaus thiab ua rau kom ntau ntxiv cov koob tshuaj, saib xyuas tus neeg mob kom zoo.

Thorvacard thaum cev xeeb tub thiab lactation

Yog tias cev xeeb tub tau tshwm sim thaum noj Atorvastatin, kev kho mob nrog cov tshuaj yuav tsum tau tsum tsis ua ntxiv. Cov kev tshawb fawb tsiaj tau pom tias cov tshuaj muaj peev xwm muaj kev phom sij rau tus me nyuam hauv plab. Cov kev tshawb fawb ntawm cov teebmeem ntawm atorvastatin hauv kev sib raug zoo rau tib neeg thaum lub cev xeeb tub tsis tau ua. Ib qho ntxiv, thaum lub sijhawm pub mis, Torvacard tsis siv, vim tias tsis muaj cov ntaub ntawv hais txog lub peev xwm ntawm statins yuav muab zais ua ke nrog mis niam. Yog tias tus poj niam tau noj cov tshuaj statins ua ntej cev xeeb tub, tom qab ntawv txais tos ntawm cov nyiaj yuav tsum tau muab tshem tawm kom tag nrho lub sijhawm tag nrho cov menyuam thiab pub niam mis. Atherosclerosis yog txoj kev kho mob qeeb qeeb, yog li tsis muaj dab tsi tseem ceeb yuav tshwm sim dhau lub sijhawm tshem tawm tshuaj. Tom qab qhov kev ua tsis tiav ntawm lactation, cov tshuaj Torvacard yog coj hauv tib lub koob tshuaj ntawm kev pom zoo ntawm tus kws kho mob.

Yuav ua li cas noj Torvacard?

Torvacard noj txhua lub sijhawm ntawm lub hnub - thaum sawv ntxov, yav tsaus ntuj lossis thaum hmo ntuj, tsis hais noj zaub mov dab tsi. Torvacard 10 mg yog thawj qhov tshuaj. Hauv qee kis, ib nrab ntawm cov ntsiav tshuaj yog tshuaj raws li thawj koob tshuaj. Yog tias qhov tshuaj ntawm 10 mg yog qhov tsis txaus, tom qab tswj cov theem ntawm cov cholesterol, Torvacard 20 mg, lossis Torvacard 40 mg yog cov tshuaj.

Cov ntau npaum ntawm cov tshuaj yuav tsum tau xaiv los ntawm tus kws kho mob tom qab kev kuaj mob tsim nyog thiab tshuaj ntsuam xyuas. Nws yog nruj me ntsis txwv tsis pub rau nws tus kheej nce koob tshuaj!

Kev phiv tshuaj thaum noj Torvacard tuaj yeem tshwm sim los ntawm ntau yam kabmob thiab cov kabmob ntawm lub cev:

1. Ntawm ib feem ntawm cov metabolism, kev hloov pauv hauv cov piam thaj hauv ntshav, qhov hnyav, lossis lub cev poob hnyav yuav tshwm sim.
2. Tej leeg tsis huv: kab ke, kev hloov pauv hauv kev saj, tsis nco qab, nco qab.
3. Kev tiv thaiv kab mob - kev ua xua ntawm tawv nqaij ua pob khaus rau anaphylactic kev poob siab.
4. Cov ntshav thiab cov ntshav hematopoietic: txo qis ntawm platelet ntau hauv cov ntshav.
5. Lub paj hlwb hauv daim ntawv npau suav phem thiab lwm txoj kev pw tsaug zog.
6. Lub plab zom mov - dyspeptic cuam tshuam nyob rau hauv daim ntawv ntawm xeev siab, cem quav, raws plab, belching, mob plab, kub siab.Tej zaum qhov kev loj hlob ntawm cov txheej txheem inflammatory nyob rau hauv lub txiav.
7. Lub cev ua ke tuaj yeem teb rau kev siv statin los ntawm kev tshwm sim ntawm kev mob hauv cov pob qij txha, cov leeg, pob txha, mob leeg, kev txhim kho ntawm myopathy, rhabdomyolysis thiab lwm yam kev tsis zoo ntawm cov leeg. Tus neeg mob uas tau noj cov tshuaj statins yuav tsum ceeb toom txog qhov yuav tsum tau mus ntsib kws kho mob yog tias muaj mob sai sai hauv cov leeg thiab cov pob txha.
8. Tsis tas li, thaum lub sij hawm kho nrog statins, kev txhim kho ntawm kev sib daj sib deev yog qhov ua tau.

Feem ntau, kev phiv tshuaj yog qhov tshwm sim ntawm kev xaiv cov tshuaj uas tsis tsim nyog lossis ntau tshaj qhov pom zoo koob tshuaj ntawm tus kws kho mob. Raws li txoj cai, tom qab kho qhov kev siv tshuaj kho, kev siv ntau ntawm cov tsos mob poob qis zuj zus, lossis qhov cuam tshuam tsis nco qab ploj tag nrho. Txawm li cas los xij, muaj cov kev mob tshwm sim, qhov tshwm sim ntawm uas yuav tsum tam sim ntawd tsis tsum kev kho mob nrog Torvacard thiab maj mam nrhiav kev pab kho mob. Cov kev ua xua no suav nrog cov leeg mob thiab ua xua.

Tshwj xeeb cov kev phom sij phom sij

Myopathy tuaj yeem ua rau txoj kev txhim kho lub raum tsis ua haujlwm, yog li tus neeg mob yuav tsum tau ceeb toom ntawm qhov yuav tsum tau txiav cov tshuaj thiab kho tus kws kho mob sai sai yog tias mob leeg. Kev tsis haum tshuaj kuj yuav tsum tshem tawm sai ntawm cov tshuaj. Kev ua xua nyob rau hauv daim ntawv ua pob thiab khaus khaus yuav tsis ua mob loj, thiab o ntawm lub ntsej muag thiab caj dab tuaj yeem ua rau bronchospasm thiab ua pa nyuaj. Ib qho mob hnyav txaus ntshai heev rau lub neej yog anaphylactic shock. Yog li, yog tias muaj qhov tsis haum tshuaj tshwm sim, tsis txhob haus tshuaj ntsiav Torvacard.

Nyob rau hauv cov ntaub ntawv ntawm ib zaug ntawm ib qho loj ntawm cov tshuaj lossis ib qho systematic dhau ntawm cov koob tshuaj pom zoo, mob atorvastatin lom yuav tshwm sim. Raws li txoj cai, ib qho overdose manifests nws tus kheej yog cov tsos mob ntawm lub cev ua tsis taus pa. Cov tshuaj tiv thaiv hauv cov ntaub ntawv no tsis muaj nyob, yog li kev kho mob ntawm kev noj tshuaj ntau dhau yog mob.

Qee qhov taw qhia rau kev kho mob statin

• Ua ntej pib kev kho mob nrog cov tshuaj uas muaj cov roj uas txhaws roj tsawg, kev ntsuas yuav tsum tau ua rau qhov tsis yog-pharmacological txo cov roj (cholesterol) ntau: kev ua kom lub cev, poob phaus, kho kev noj haus. Tom qab ntawd, yog tias cov kev ntsuas no tsis ua rau cov txiaj ntsig xav tau, statins yog tshuaj.

• Kuaj tshuaj xyuas lub siab ua haujlwm ntsuas yuav tsum tau ua ua ntej pib kev kho mob, thiab tom qab ntawd ib txwm, tsawg kawg ob zaug hauv ib xyoos thiab tom qab txhua qhov nce ntawm cov tshuaj Torvacard.
• Yog tias qhov siab hepatic dhau, tus neeg mob yuav tsum tau soj ntsuam los ntawm tus kws kho mob kom txog thaum lawv rov qab zoo li qub.
• Kev ceev faj yuav tsum tau siv thaum kev sau daim ntawv yuav tshuaj nrog rau lwm cov tshuaj. Kev siv lwm cov tshuaj yuav tsum tau coj mus rau hauv tus account, txij li Atorvastatin muaj peev xwm cuam tshuam nrog qee yam tshuaj pharmacological.
• Thaum noj Torvacard, kev ceev faj yuav tsum ua kom tau ua haujlwm nrog qhov chaw ntawm kev phom sij ntau ntxiv thiab tsav tsheb.

Torvacard analogues thiab tus nqi ntawm cov tshuaj

Hauv cov chaw muag tshuaj, muaj ntau yam tshuaj uas muaj Atorvastatin, uas yog analogues ntawm Torvacard. Piv txwv li, kev npaj ntawm lub tuam txhab Krka - Atoris, Pfizer - Liprimar tseem nrov ntawm cov kws kho mob. Cov neeg tsim khoom hauv tsev kuj tsim cov Atorvastatin hauv ntau cov tshuaj - 10, 20, 30, 40 thiab 80 mg. Tus nqi ntawm Torvakard analogues nyob ntawm tus neeg tsim khoom lag luam tus nqi, thaj tsam kev lag luam wholesale thiab muag khoom, ntxiv rau txoj cai nqe ntawm lub tsev muag tshuaj tshwj xeeb. Txawm li cas los xij, Atorvastatin npaj muaj nyob rau hauv Cov npe ntawm Cov Tshuaj Tseem Ceeb thiab Cov Tshuaj Tseem Ceeb, thiab yog li muaj cov nqi tsis tshua siab tshaj cov tshuaj no tsis tuaj yeem raug nqi. Qhov tseem kim tshaj plaws ntawm cov nyiaj muaj Atorvastatin yog thawj cov tshuaj Liprimar, tsim los ntawm lub tuam txhab German Pfizer.

Qhov ua tau zoo ntawm cov tshuaj muaj Atorvastatin, niaj hnub no tsis muaj kev ua xyem xyav, yog li ntawd, statins tau dav siv hauv kev kho mob.

Txoj cai zoo tshaj plaws thiab nyab xeeb

Txhua txhua hnub, teeb meem ntawm pathologies thiab kab mob ntawm cov hlab plawv yog los ua ib qho tseem ceeb, vim tias nws yog qhov tseeb mob plawv uas nyob hauv thawj qhov chaw ntawm qhov ua rau kev tuag ntawm cov neeg mob. Ib ntawm cov kab mob coj thiab feem ntau yog, ntawm chav kawm, atherosclerosis. Thiab xyov yog dab tsi statins yog qhov muaj kev nyab xeeb thiab ua hauj lwm zoo tshaj plaws rau hauv kev sib ntaus tawm tsam kev tsub zuj zuj thiab tsim cov roj endogenous.

Tus yam ntxwv dav

Cov sawv cev ntawm pawg no feem ntau muab faib ua 2 pawg: ntuj thiab hluavtaws, tsim cuav. Thiab rau txuas ntxiv rau 4 tiam. Rau thawj tiam yog tshwj xeeb ntuj statins secreted los ntawm nceb. Lwm tiam yog synthetically bred. Dab tsi yog lawv lub zog:

1. Thawj tiam yog lovastatin, simvastatin. Lawv muaj qhov tshwm sim tshuaj tsawg dua li cov tshuaj ntawm lwm tiam, cov kev mob tshwm sim.
2. Qhov thib ob tiam yog fluvastatin. Piv nrog rau seem kev so, siv sijhawm ntev dua, tab sis lub sijhawm no, qhov kev xav ntau ntawm cov tshuaj tseem nyob hauv cov ntshav.
3. Lub cim thib peb yog atorvastatin. Cov neeg tseem ceeb txo qis qib triglycerides (THC) thiab lipoproteins uas tsis muaj ntau ntau (LDL), thiab tseem muaj cov lipoproteins ntau-tsawg (HDL) tsim nyog rau pov tseg cov roj (cholesterol) phem.
4. Qhov thib plaub tiam yog rosuvastatin. Tseem ceeb nce kev ua tau zoo thiab kev nyab xeeb, piv nrog ntxiv.

Ntxiv rau ib qho kev ua haujlwm - cov kev tiv thaiv kab mob hauv ntshav siab, txhua qhov tshuaj muaj cov cim tshwj xeeb thiab cov txiaj ntsig ntxiv. Qhov no yog vim muaj qhov xwm txheej tshwm sim, zoo li rau ib tus neeg.

Khoom Piav Qhia

Lo lus teb rau lo lus nug "uas statins muaj kev nyab xeeb dua thiab muaj txiaj ntsig zoo dua?" Feem ntau nyob ntawm lawv lub zog thiab biochemical cov yam ntxwv. Statins cuam tshuam cov synthesis ntawm cov roj cholesterol hauv lub siab, los ntawm nws qhov kev txwv. Qhov no tshwm sim vim qhov thaiv ntawm cov enzyme koom nrog hauv cov synthesis ntawm cov roj (endogenous cholesterol) - HMG-CoA reductase. Qhov enzyme catalyzes (ua kom nrawm) cov hluavtaws mevalonic acid, uas yog lub zog ua ntej cov roj (cholesterol). Ntxiv nrog rau nws cov txiaj ntsig tseem ceeb, statins muaj ib tug lej ntawm lwm tus:

• cov nyhuv ntawm viav endothelium, los ntawm kev txo qhov mob thiab txo kev pheej hmoo ntawm cov ntshav txhaws,
• kev tsim kho ntawm kev sib txuas ntawm nitric oxide, uas ua rau kom nthuav dav ntawm cov hlab ntsha thiab lawv cov kev so,
• txhawb atherosclerotic plaque stability.

Ntxiv nrog rau kev tiv thaiv thiab kev tiv thaiv ntawm atherosclerosis, statins tseem muaj ntau cov teebmeem ntawm lwm yam kab mob:

1. Kev tiv thaiv ntawm myocardial infarction. Hauv kev sib piv nrog lwm cov tshuaj tsom rau kev kho tus mob no, statins zoo tshaj plaws. Piv txwv li, kev tshawb fawb txog kev siv resuvostatin pom tias muaj kev txo qis ntawm kev pheej hmoo ntawm myocardial infarction hauv cov neeg uas coj nws rau 2 xyoos.
2. Nrog rau kev tiv thaiv ntawm lub plawv nres, lawv txo qhov ntxim nyiam ntawm ischemic mob stroke.
3. Nyob rau lub sijhawm tom qab rov qab kho dua tshiab, statins yuav tsum ua. Nrog rau kev kho mob dog dig, lawv muaj cov txiaj ntsig zoo thiab ua rau tus txheej txheem rov qab los.

Ntau qhov kev pom ntawm qhov kev txiav txim ntawm cov hlab plawv tau ua rau pab pawg ntawm statins, nrov tshaj plaws thiab ua tau zoo, hauv kev sib piv nrog rau lwm cov tshuaj.

Cov Yuav Tsum Muaj

Thaum muab cov tshuaj los ntawm pawg no, tus kws kho mob yuav tsum ua tib zoo thiab ua tib zoo saib, vim tias muaj ntau tus lej nuances. Piv txwv li, cov menyuam ntxhais yuav tsum tau muab kev txwv kom tsis txhob noj tshuaj thaum muaj kev kho mob, vim tias statins yuav tsum tsis txhob noj los ntawm cov poj niam cev xeeb tub. Yog tias yuav tsum tau siv cov tshuaj los ntawm tus poj niam cev xeeb tub, ces nws yog ib qho tsim nyog yuav tsum coj mus rau hauv lub sijhawm, nrog rau txhua yam kev pheej hmoo.

Nyob rau hauv dav dav, hauv qab no lub ntsiab contraindications yuav txawv:

• phiv ntau yam, nrog rau cov tshuaj intolerance,
• cev xeeb tub
• kab mob ntawm lub raum, kab mob endocrine, mob qog,
• kev ntshawv siab nyob hauv cov leeg musculoskeletal,
• mob siab thiab mob siab daim siab,
• mob ntshav qab zib mellitus.

Cov kev tiv thaiv tsis zoo yog ib qho tseem ceeb hauv kev siv cov statins. Qhov tseeb ntawm cov ntaub ntawv uas tau txais los ntawm tus neeg mob, lub caij nyoog noj tshuaj, muaj cov kab mob mus ntev. tag nrho cov no cuam tshuam qhov zoo lossis tsis zoo ntawm kev noj tshuaj los ntawm cov neeg mob.

Sab sij huam

Feem ntau, statins raug noj zoo, tsis muaj kev phiv tshuaj, tau ntev. Thaum lub sij hawm qhov kev tshawb fawb, nws tau sau tseg tias tsuas yog 3% ntawm cov ncauj lus tsis muaj kev cuam tshuam, tab sis lawv tshwm sim hauv cov neeg uas tau noj cov tshuaj ntau dua 5 xyoos.

Muaj kev pheej hmoo ntawm myopathy, tab sis nws tsawg heev (0.1-0.5%). Txoj kev yeej ntawm myocytes (cov leeg nqaij ua lub cev), ncaj qha nyob ntawm qhov kev saib xyuas ntawm cov tshuaj, hnub nyoog (cov neeg laus dua 70-80 yog cov mob rau cov leeg mob ntau dua), kev noj zaub mov tsis muaj txiaj ntsig, nrog rau cov teeb meem ntshav qab zib.

Tsis tas li ntawd, nrog qhov tshwm sim tsis ntau tshaj 1%, CNS cuam tshuam tuaj yeem tshwm sim: mob taub hau, kiv taub hau, pw tsaug zog, cuam tshuam dav dav. Ib qho kev cuam tshuam ntawm lub ntsws ua pa tau qhia los ntawm rhinitis, qhov tshwm sim ntawm mob ntsws. Lub plab zom mov tau teb hauv daim ntawv ntawm xeev siab, ntuav, cem quav. Tab sis nws tsim nyog teev tias txhua qhov tshwm sim saum toj no tsuas yog hauv 1% ntawm cov neeg mob uas tau txais nws.

Feem ntau, kev sib npaug, kev siv ceev faj thiab raug siv tsuas yog muab cov txiaj ntsig zoo, txawm li cas los xij, yog tias koj siv cov tshuaj tsis tswj xyuas thiab siv sijhawm ntev, ces cov kev mob tshwm sim no kuj tseem yuav tshwm sim:

• mob hauv plab, plab hnyuv, cem quav, ntuav,
• amnesia, insomnia, paresthesia, kiv taub hau,
• ua rau hauv cov ntshav txhaws ntshav (thrombocytopenia),
• o, rog, impotence rau tus txiv neej,
• mob leeg, mob nraub qaum, mob caj dab, mob myopathy.

Ua ke nrog qee yam tshuaj, piv txwv li, lipid-qis dua, qhov tshwm sim tsis zoo kuj yuav tshwm sim.

Cov tshuaj muaj kev nyab xeeb tshaj plaws ntawm cov pab pawg

Xa mus rau ntau cov kev tshawb fawb, cov lus qhuab qhia tseem pom tau cov lus teb rau lo lus nug - uas statins yog qhov muaj kev nyab xeeb thiab ua tau zoo tshaj? Ua ntej tshaj plaws, nws tsim nyog qhia txog atorvastatin, qhov siv tshaj plaws thiab qhia cov txiaj ntsig kev tshawb fawb zoo tshaj plaws. Rosuvastatin yog me ntsis tsawg dua siv. Zoo, peb tus kws tshaj lij tawm emit simvastatin, kuj yog ib qho tshuaj txhim khu kev qha.

Rosuvastatin

Rosuvastatin yog cov tshuaj synthetically tsim ntawm cov pab pawg neeg statin, muaj kev tshaj tawm lub suab hydrophilicity vim qhov uas nws ua rau lub siab ua rau lub siab raug txo qis, thiab tseem nce cov txiaj ntsig ntawm kev tiv thaiv kev tsim cov qog lipoproteins tsawg (LDL). LDL yog qhov sib txuas tseem ceeb hauv cov roj (synthesis) roj. Rosuvastatin tsis ua rau muaj kev cuam tshuam rau cov nqaij ntshiv, uas yog, koj tuaj yeem coj nws thiab tsis txhawj txog qhov tshwm sim ntawm myopathy thiab mob leeg.

Kev siv cov koob tshuaj 40 mg muab txo qis hauv LDL mus rau 40%, thiab tib lub sijhawm, kev nce siab hauv lipoproteins ntau (HDL - txo cov kev pheej hmoo ntawm atherosclerosis) los ntawm 10%. Rosuvastatin muaj txiaj ntsig zoo dua li lwm cov tshuaj. Piv txwv li, kev siv koob tshuaj ntawm 40 mg muaj qhov muaj zog tshaj qhov noj 80 mg ntawm atorvastatin. Ib koob tshuaj 20 mg tuaj yeem txo qhov LDL ntau, ib yam li 80 mg ntawm tib lub atorvastatin.

Cov txiaj ntsig kom ua tau zoo yog manifested twb nyob hauv thawj lub lim tiam ntawm kev siv, kom txog rau thaum lub asthiv thib ob nws nce mus txog 90-95%, thiab hauv plaub nws nce mus txog qhov siab tshaj plaws thiab raug tswj hwm tas li, raug kho mob tsis tu ncua.

Simvastatin

Raws li txoj kev tshawb nrhiav, kev noj cov tshuaj no rau 5 xyoos txo cov kev pheej hmoo mob vascular thiab kab mob hauv lub caij tom qab lub hnub dhau los 10%, ntxiv rau qhov feem pua ​​zoo ib yam rau cov neeg mob plawv, mob ntshav qab zib thiab mob stroke.

Nws tau raug pov thawj tias ntau dua 2 xyoos, qhov sib piv ntawm lipoproteins ua lub luag haujlwm / siv cov roj (cholesterol) yog ua kom zoo dua qub, qhov kev pheej hmoo ntawm cov ntshav txhaws hauv cov hlab ntshav txhaws yog txo.

Feem ntau, statins zoo heev rau lawv siv. Muaj kev pheej hmoo ntawm kev phiv, tab sis nws yog qhov me me. Nws tag nrho yog nyob ntawm qhov ceev faj thiab nco ntsoov ntawm tus neeg mob. Thaum kuaj xyuas tus tib neeg yam ntxwv ntawm tus neeg mob, nws cov ntaub ntawv muaj hnub nyoog thiab keeb kwm yav dhau los, nws muaj peev xwm txiav txim siab seb cov statin twg yuav tsum muaj txiaj ntsig zoo tshaj plaws.

Yuav xaiv cov tshuaj zoo li cas?

Hauv cov khw muag tshuaj, koj tuaj yeem nrhiav tau ob hom tshuaj. Qhov thib ib yog qhov qub, thawj txoj kev loj hlob ntawm lub chaw tsim tshuaj yeeb tshuaj uas muaj daim ntawv tso cai rau nees nkaum xyoo.

Qhov no txhais tau hais tias yuav luag ib xyoo plaub lub hlis twg, tsuas yog lub tuam txhab no tuaj yeem tsim cov tshuaj no. Txog thaum daim ntawv patent tau tas sij hawm lawm, kev npaj tshuaj analogue tsis tuaj yeem tshwm nyob rau hauv txee. Tab sis thaum kawg ntawm lub sijhawm no, kev tiv thaiv raug muab tso tseg thiab cov ntawv luam tshwm. Hauv qhov no, qhov qub tseem yog ib qho kev txiav txim ntawm qhov ntau ntau dua.

Qhov laj thawj ntawm no yooj yim piav qhia - rau kev tsim cov khoom lag luam tshwj xeeb, cov kws tshawb fawb tau siv nyiaj ntau txhiab lab nyiaj los mus sim cov chaw kuaj mob ntev ntev thiab lees paub qhov ua tau zoo thiab kev nyab xeeb ntawm ntau cov neeg yeem yeem. Cov txheej txheem yuav siv sij hawm ntau dua kaum xyoo.

Generics (lossis generics), uas yog pab pawg thib ob, yog qhov tseem ceeb clone kev npaj nrog cov yam ntxwv zoo sib xws.

Txhawm rau ua lawv, koj yuav tsum noj mis nyuj tov npaj, ntxiv cov neeg dhau los rau qhov qub, tuaj nrog lub npe kom yooj yim thiab muab tso rau muag.

Cov khoom thev naus laus zis tsis zoo ib yam li thawj cov tshuaj, yog li cov kev hloov pauv hauv tib neeg ua ntau.

Tus nqi yog nyob ntawm ntau yam: cov qauv kev tsim tawm, kev sib txuas ntxiv ntawm cov sib txuas ntxiv, muaj pes tsawg qhov kev sim tshuaj uas nws tau dhau los. Kev tshawb nrhiav tuaj yeem faib ua:

1. Bioequivalent, uas yog, kuaj xyuas qhov yuam kev nrog daim ntawv qhia,
2. Kws Tshuaj - paub tseeb qhov tseeb mechanism ntawm kev txiav txim,
3. Thiab kev kho mob, kawm kev ua haujlwm ntawm cov generics rau tib neeg.

Tus nqi yog ncaj ncaj rau cov naj npawb ntawm cov kev tshawb fawb - uas yog, muaj ntau, muaj cov khoom kim dua.

Hauv cov pab pawg ntawm lipid-txo cov tshuaj, atorvastatin yog thawj. Thaum kuaj mob mus ntev kawg kaum ob lub hlis, nws pom cov lus hauv qab no:

• Qhov siab ntawm qis lipoproteins tsawg dua 55%,
• Cov roj (cholesterol) tag nrho poob 46%,
• Cov qib ntawm cov lipoproteins uas tau nce siab tau nce (qhov no yog "zoo" cov cholesterol, nws tsis txhaws cov hlab ntsha) 4%.

Qhov koob tshuaj uas siv los ntawm cov neeg ua hauj lwm pub dawb yog 10 milligrams ib hnub.

Thaum muab piv rau cov tshuaj feem ntau nrog nws, nws tau pom tias lwm cov statins xav tau ntau dua lub siab xav kom ua tiav cov nyhuv - rau Torvacard nws yog 20 milligrams, rau Simvastatin - 40, thiab rau Fluvastatin ntau npaum li 80.

Cov ntaub ntawv no tsis pom zoo nyob hauv daim ntawv luam, ua qhov txawv loj.

Torvacard - cov lus qhia rau kev siv, tshuaj xyuas, tshuaj yeeb yaj kiab thiab tso tawm cov qauv (10 mg, 20 mg thiab 40 mg ntsiav tshuaj) ntawm cov tshuaj statin kom txo cov roj (cholesterol) thiab tiv thaiv kab mob plawv hauv cov laus, menyuam yaus thiab cev xeeb tub

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj Torvard. Kev tshuaj xyuas cov neeg tuaj saib lub tsev kawm ntawv - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Torvacard statin hauv lawv cov kev coj ua tau hais tawm.Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov cim ntawm Torvacard nyob rau hauv muaj cov qauv txheej txheem qauv. Siv los txo cov roj (cholesterol) thiab tiv thaiv cov kab mob plawv rau cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation.

Torvacard yog qhov tshuaj tiv thaiv hypolipidemic los ntawm pab pawg ntawm statins. Xaiv cov kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl-coenzyme A rau mevalonic acid, uas yog ib qho ua ntej rau steroids, suav nrog cov roj (cholesterol). Hauv lub siab, cov roj triglycerides thiab cov roj (cholesterol) nyob rau hauv VLDL, nkag mus rau cov ntshav ntshav thiab raug thauj mus rau cov ntaub so ntswg. Los ntawm VLDL, LDL yog tsim thaum muaj kev cuam tshuam nrog LDL receptors. Atorvastatin (cov tshuaj tseem ceeb ntawm cov tshuaj Torvard) txo cov ntshav plasma cholesterol (Ch) thiab lipoproteins los ntawm kev tiv thaiv HMG-CoA reductase, muab cov roj cholesterol hauv lub siab thiab nce cov LDL receptors hauv lub siab rau ntawm lub ntsej muag ntawm tes, uas ua rau nce siab thiab catabolism ntawm LDL Cov.

Atorvastatin txo qhov tsim ntawm LDL, ua rau muaj qhov tshaj tawm thiab pheej ua ntxiv rau hauv cov dej num ntawm LDL receptors. Torvacard txo qis LDL ntau ntau hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, uas feem ntau tsis txaus siab los kho nrog lwm tus neeg mob hypolipidemic.

Nws txo cov theem ntawm cov roj (cholesterol) tag nrho los ntawm 30-46%, LDL - los ntawm 41-61%, apolipoprotein B - los ntawm 34-50% thiab triglycerides - los ntawm 14-33%, ua rau muaj qhov nce ntawm HDL-C thiab apolipoprotein A. Dose-dependently txo qib ntawm LDL hauv cov neeg mob nrog homozygous cov kab mob siab hypercholesterolemia tiv taus kev kho mob nrog lwm tus neeg mob hypolipidemic.

Atorvastatin calcium + excipients.

Kev tshem tawm yog qhov siab. Khoom noj khoom haus me ntsis txo qhov nrawm thiab ncua sijhawm ntawm kev nqus ntawm cov tshuaj (los ntawm 25% thiab 9%, feem), tab sis qhov txo qis hauv LDL cov roj (cholesterol) zoo ib yam li cov kev siv atorvastatin tsis muaj zaub mov. Qhov kev nkag siab ntawm atorvastatin thaum thov thaum yav tsaus ntuj yog qis dua thaum sawv ntxov (kwv yees li 30%). Txoj kab sib txuas ntawm qhov txheeb ze ntawm qhov nqus ntawm qhov nqus thiab qhov tshuaj ntawm cov tshuaj tau qhia tawm. Nws yog metabolized feem ntau hauv lub siab. Nws raug tawm hauv cov hnyuv nrog cov kua tsib tom qab mob hepatic thiab / lossis cov kab mob hnyav ntxiv (tsis yauv ua kom nkag mus rau hauv lub cev). Cov kev cuam tshuam tiv thaiv kev ua haujlwm tiv thaiv HMG-CoA reductase tau tshwj tseg los ntawm qhov muaj cov khoom siv tshuaj nquag. Tsawg dua 2% ntawm kev noj tshuaj hauv qhov ncauj yog txiav txim siab nyob rau hauv cov zis. Nws tsis yog nyob hauv tus kab mob hemodialysis.

• hauv kev sib xyaw nrog kev noj zaub mov kom txo tau cov theem siab ntawm tag nrho cov roj (cholesterol), roj cholesterol-LDL, apolipoprotein B thiab triglycerides thiab nce roj cholesterol-HDL rau cov neeg mob thawj hypercholesterolemia, heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia (hom 2a thiab 2) ,
• hauv kev sib xyaw nrog kev noj zaub mov noj rau kev kho mob ntawm cov neeg mob uas tau txais txiaj ntsig ntshav ntau ntau (yam 4 raws li Fredrickson) thiab cov neeg mob dysbetalipoproteinemia (hom 3 raws li Fredrickson), hauv kev kho kev noj zaub mov tsis muaj txiaj ntsig,
• kom txo cov theem ntawm tag nrho cov roj (cholesterol) thiab LDL-C hauv cov neeg mob homozygous tsev neeg hypercholesterolemia, thaum kev noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis zoo yog tsis muaj txiaj ntsig txaus (ntxiv rau kev kho lipid-txo qis, suav nrog autohemotransfusion ntawm LDL-purified ntshav),
• cov kab mob ntawm cov hlab plawv (hauv cov neeg mob uas muaj kev pheej hmoo ntau ntxiv rau cov kab mob plawv - cov neeg laus dua 55 xyoos, haus luam yeeb, mob ntshav siab, ntshav qab zib mellitus, mob hlab ntsha hauv lub cev, mob hlab ntsha tawg, sab laug ventricular hypertrophy, protein / albuminuria, mob hlab ntshav hlab ntshav hauv cov neeg nyob ze ), suav nrogtawm tsam keeb kwm ntawm dyslipidemia - theem nrab prophylaxis nrog lub hom phiaj ntawm kev txo qis kev pheej hmoo tag nrho ntawm txoj kev tuag, myocardial infarction, mob stroke, rov pw hauv tsev kho mob rau angina pectoris thiab xav tau tus txheej txheem kho kom rov zoo siab.

10 mg, 20 mg thiab 40 mg zaj duab xis-ntsiav tshuaj.

Cov lus qhia rau kev siv thiab regimen

Ua ntej kev teem caij Torvacard, tus neeg mob yuav tsum qhia kev noj haus kom tsis txhob lipid-txo cov zaub mov, uas nws yuav tsum tau txuas ntxiv mus kom thoob rau txhua lub sijhawm ntawm kev kho.

Thawj koob tshuaj yog qhov nruab nrab ntawm 10 mg ib hnub ib zaug. Qhov kev txhaj tshuaj nws txawv ntawm 10 txog 80 mg ib hnub ib zaug. Cov tshuaj tuaj yeem noj tau txhua lub sijhawm ntawm ib hnub, tsis hais lub sijhawm noj mov. Cov koob tshuaj yog xaiv rau hauv kev txiav txim siab thawj theem ntawm LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib leeg rau ib leeg. Thaum pib kho thiab / lossis thaum qhov nce ntxiv ntawm lub tshuaj Torvacard, nws yog qhov yuav tsum tau soj ntsuam cov ntshav lipid ntau ntau txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li. Qhov tshuaj ntau tshaj txhua hnub yog 80 mg hauv 1 koob tshuaj.

Nrog thawj hypercholesterolemia thiab sib xyaw hyperlipidemia, feem ntau, ib koob tshuaj 10 mg ntawm Torvacard ib hnub ib zaug yog txaus. Cov txiaj ntsig kho tau zoo yog pom tom qab 2 lub lis piam, raws li txoj cai, thiab cov txiaj ntsig kho siab kawg feem ntau pom tom qab 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv no mob tsawv.

• mob taub hau
• asthenia
• insomnia
• kiv taub hau
• tsaug zog
• npau suav phem
• amnesia
• kev nyuaj siab
• peripheral neuropathy
• ataxia
• paresthesia
• xeev siab, ntuav,
• cem quav lossis raws plab
• flatulence
• mob plab
• anorexia lossis qab los noj mov,
• myalgia
• arthralgia,
• mob hlwb
• mob mob vwm
• rov qab mob
• cramps hauv plab nqaij nyuj ntawm ob txhais ceg,
• khaus tawv
• ua pob
• urticaria
• angioedema,
• anaphylactic kev poob siab,
• ua pob khaus khaus,
• polymorphic exudative erythema, suav nrog Stevens-Johnson mob
• tshuaj lom neeg mob hlwb (Lyell syndrome),
• hyperglycemia
• ntshav qab zib,
• mob hauv siab
• peripheral edema,
• impotence
• alopecia
• tinnitus
• hnyav
• malaise
• tsis muaj zog
• thrombocytopenia
• theem ob lub raum tsis ua haujlwm.

• cov kab mob nquag ua haujlwm lossis nce siab hauv kev ua haujlwm ntawm transaminases hauv cov ntshav cov ntshav (ntau dua 3 zaug piv nrog VGN) ntawm cov keeb kwm tsis paub,
• mob rau daim siab ua haujlwm (mob hnyav A thiab B ntawm Kev Siv Me Nyuam Pugh),
• cov kab mob muaj keeb, xws li lactose intolerance, lactase deficiency lossis glucose-galactose malabsorption (vim muaj lactose hauv tshuaj muaj pes tsawg leeg),
• cev xeeb tub
• kev pub mis
• Cov poj niam muaj hnub nyoog yug me nyuam uas tsis siv cov hau kev tsim nyog ntawm kev tswj kom tsis muaj menyuam,
• cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb tsis raug),

Cev xeeb tub thiab lactation

Torvacard yog contraindicated nyob rau hauv cev xeeb tub thiab lactation (pub niam mis).

Txij li cov roj (cholesterol) thiab cov tshuaj sib tov los ntawm cov roj (cholesterol) yog qhov tseem ceeb rau kev loj hlob ntawm tus me nyuam hauv plab, qhov kev pheej hmoo ntawm kev txwv tsis pub HMG-CoA reductase ntau dua li cov txiaj ntsig ntawm kev siv tshuaj thaum cev xeeb tub. Thaum lovastatin (ib qho HMG-CoA reductase inhibitor) nrog dextroamphetamine yog siv rau thawj peb lub hlis thaum cev xeeb tub, mob ntawm kev yug menyuam rau cov pob txha deformation, mob pob txha-esophageal fistula, thiab anus atresia yog paub. Yog tias cev xeeb tub raug kuaj pom thaum kho nrog Torvacard, cov tshuaj yuav tsum tau txiav tawm tam sim ntawd, thiab cov neeg mob yuav tsum ceeb toom rau qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Yog tias nws yuav tsum tau siv cov tshuaj thaum lactation, muab cov peev xwm muaj qhov tsis zoo hauv cov menyuam mos, qhov teeb meem ntawm kev txwv tsis pub niam mis rau menyuam yuav tsum raug kho.

Kev siv hauv cov poj niam ntawm lub hnub nyoog yug me nyuam yog ua tau tsuas yog siv tau txoj hauv kev tiv thaiv kom siv tau. Yuav tsum qhia rau tus neeg mob tias qhov muaj feem yuav muaj feem yuav kho tus me nyuam hauv plab.

Cov tshuaj yog contraindicated rau siv nyob rau hauv cov menyuam yaus thiab tub ntxhais hluas hnub nyoog qis dua 18 xyoo (kev ua hauj lwm zoo thiab kev nyab xeeb tsis tau tsim).

Ua ntej pib Torvacard txoj kev kho, nws yog ib qho tsim nyog los sim ua kom tau txais kev tswj hwm ntawm hypercholesterolemia los ntawm kev noj zaub mov kom txaus, ua kom lub cev muaj zog, poob phaus hauv cov neeg mob rog thiab kho lwm yam mob.

Kev siv HMG-CoA reductase inhibitors kom txo cov ntshav lipids tuaj yeem ua rau muaj kev hloov pauv hauv cov khoom siv biochemical uas muaj kev cuam tshuam ntawm daim siab ua haujlwm. Lub siab ua haujlwm yuav tsum tau saib xyuas ua ntej pib siv tshuaj, 6 lub lis piam, 12 lub lis piam tom qab pib noj Torvacard thiab tom qab txhua koob nce, thiab tseem tsis tseg (piv txwv, txhua 6 lub hlis). Kev nce ntxiv ntawm kev ua si ntawm hepatic enzymes hauv cov ntshav cov ntshav tuaj yeem pom thaum lub sijhawm Torvard kho (feem ntau hauv thawj 3 lub hlis). Cov neeg mob uas muaj qhov nce ntawm transaminase yuav tsum tau saib xyuas kom txog thaum lub enzyme rov qab los rau hauv qub. Thaum qhov txiaj ntsig ntawm ALT lossis AST yog ntau dua 3 zaug siab dua li VGN, nws raug nquahu kom txo qis ntawm Torvacard lossis tsum tsis kho.

Kev kho mob nrog Torvacard yuav ua rau mob myopathy (mob nqaij thiab tsis muaj zog ua ke nrog kev nce hauv CPK kev ua si los ntawm ntau dua 10 zaug piv nrog VGN). Torvacardum tuaj yeem ua rau muaj kev nce siab ntau ntxiv ntawm CPK ntshiab, uas yuav tsum raug coj mus rau hauv qhov kev ntsuas qhov txawv txav ntawm lub hauv siab. Cov neeg mob yuav tsum tau ceeb toom tias lawv yuav tsum tau sab laj nrog kws kho mob sai sai yog tias tsis hnov ​​qhov mob lossis cov leeg tsis muaj zog, tshwj xeeb tshaj yog tias lawv nrog mob tshwm sim lossis kub taub hau. Txoj kev kho Torvard yuav tsum tsis ua mus ib ntus los sis txiav tsis ua tiav yog muaj cov tsos mob ntawm tus mob myopathy lossis muaj kev pheej hmoo rau kev tsim kho lub raum tsis ua haujlwm vim mob rhabdomyolysis (piv txwv li, mob hnyav, mob ntshav qis, phais ntshav qis, mob hnyav, mob tshwm sim, mob hnyav ntawm lub cev, endocrine thiab electrolyte cuam tshuam thiab mob chua leeg). )

Cuam tshuam rau kev muaj peev xwm tsav lub tsheb thiab ua haujlwm nrog kev ua haujlwm

Qhov tshwm sim tsis zoo ntawm Torvacard ntawm kev muaj peev xwm tsav tsheb thiab koom nrog lwm yam uas yuav tsum muaj kev kub siab thiab ceev ntawm lub hlwb kev xav tau tsis tau ceeb toom.

Nrog rau kev siv cyclosporine, fibrates, erythromycin, clarithromycin, cov tshuaj tiv thaiv kab mob thiab tshuaj tua kab mob ntawm pab pawg azole, nicotinic acid thiab nicotinamide, tshuaj uas thaiv cov metabolism hauv kev sib kho los ntawm CYP450 isoenzyme 3A4, thiab / lossis kev thauj tshuaj, cov tshuaj loog ntawm ntshav atorvastatin thiab ntshav ntawm lub nce. Thaum sau cov tshuaj no, cov txiaj ntsig uas xav tau thiab qhov kev pheej hmoo ntawm kev kho yuav tsum tau ua tib zoo ntsuas, cov neeg mob yuav tsum tau soj ntsuam kom tsis tu ncua kom paub cov leeg mob lossis tsis muaj zog, tshwj xeeb tshaj yog thawj lub hlis ntawm kev kho mob thiab thaum lub sijhawm nce ntxiv ntawm ib qho tshuaj twg, ib ntus txiav txim siab cov haujlwm ntawm KFK, txawm hais tias qhov kev tswj hwm no tsis tso cai tiv thaiv kev txhim kho ntawm mob myopathy hnyav. Kho txoj kev kho Torvard yuav tsum tsis ua mus ntxiv yog tias muaj qhov cim tseg hauv CPK cov dej num lossis qhov pom tseeb tias muaj tus mob myopathy.

Torvacard tsis muaj qhov teeb meem loj hauv kev kho mob rau kev ua haujlwm ntawm terfenadine nyob rau hauv cov ntshav ntshav, uas yog metabolized feem ntau los ntawm 3A4 CYP450 isoenzyme, thiab yog li ntawd nws tsis zoo li atorvastatin tuaj yeem cuam tshuam loj rau pharmacokinetic tsis sib haum ntawm lwm qhov qis ntawm 3A4 CYP450 isoenzyme. Nrog rau kev siv tib txhij ntawm atorvastatin (10 mg ib hnub ib zaug) thiab azithromycin (500 mg ib hnub ib zaug), qhov concentration ntawm atorvastatin hauv cov ntshav ntshav tsis hloov.

Nrog kev noj ib txhij ntawm atorvastatin thiab cov kev npaj muaj magnesium thiab aluminium hydroxides, qhov concentration ntawm atorvastatin hauv cov ntshav ntshav poob qis li 35%, txawm li cas los xij, cov neeg kawm ntawv qib qis hauv qib LDL-C tsis tau hloov pauv.

Nrog rau kev siv ua ke ntawm colestipol, ntshav ntau ntawm atorvastatin txo los ntawm kwv yees li 25%. Txawm li cas los xij, lipid-txo cov nyhuv ntawm kev sib txuam ntawm atorvastatin thiab colestipol ntau dua qhov ntawm txhua cov tshuaj ib tus zuj zus.

Nrog rau kev siv tib lub sijhawm Torvacard tsis cuam tshuam rau lub pharmacokinetics ntawm phenazone, yog li ntawd, kev sib cuam tshuam nrog lwm cov tshuaj metabolized los ntawm tib CYP450 isoenzymes tsis xav.

Thaum kawm txog kev cuam tshuam ntawm atorvastatin nrog warfarin, cimetidine, phenazone, tsis muaj cov cim ntawm thaj chaw muaj kev cuam tshuam loj tau pom.

Kev siv ib txhij siv cov tshuaj uas txo cov kev ua kom zoo ntawm cov tshuaj hormones endogenous steroid (suav nrog cimetidine, ketoconazole, spironolactone) muaj kev pheej hmoo ntawm kev txo qis cov tshuaj hormones endogenous steroid (ceeb toom yuav tsum tau siv).

Muaj tsis muaj kev cuam tshuam los ntawm kev muaj mob loj ntawm kev sib txuam ntawm atorvastatin nrog cov tshuaj tiv thaiv kab mob, nrog rau estrogens.

Nrog tib lub sijhawm siv ntawm Torvacard ntawm koob tshuaj 80 mg rau ib hnub thiab tshuaj tiv thaiv qhov ncauj muaj norethindrone thiab ethinyl estradiol, qhov nce ntau ntawm cov tshuaj norethindrone thiab ethinyl estradiol tau pom los ntawm kwv yees li 30% thiab 20%, feem. Cov nyhuv no yuav tsum raug txiav txim siab thaum xaiv qhov ncauj tsis haum rau cov poj niam tau txais Torvacard.

Nrog rau kev siv tib txhij ntawm atorvastatin ntawm koob tshuaj 80 mg thiab amlodipine ntawm koob tshuaj 10 mg, pharmacokinetics ntawm atorvastatin hauv lub xeev equilibrium tsis hloov pauv.

Nrog kev tswj hwm rov qab ntawm digoxin thiab atorvastatin ntawm koob tshuaj 10 mg, qhov sib npaug ntawm digoxin hauv cov ntshav ntshav tsis hloov. Txawm li cas los xij, thaum digoxin tau siv nrog kev sib xyaw nrog atorvastatin ntawm ib koob ntawm 80 mg rau ib hnub, qhov siab ntawm digoxin nce ntxiv txog 20%. Cov neeg mob tau txais digoxin ntau ntxiv nrog atorvastatin xav tau kev soj ntsuam.

Kev kawm txog kev sib cuam tshuam nrog lwm yam tshuaj tsis tau ua.

Analogs ntawm cov tshuaj Torvacard

Cov qauv ntawm cov qauv ua haujlwm:

Cov tshuaj hauv cov pab pawg (pharmacological statins):

Liprimar: kev taw qhia rau kev siv

Cov tshuaj yog kws kho rau cov kab mob nram qab no:

• hypercholesterolemia,
• tag nrho cov hom hyperlipidemia,
• dysbetalipoproteinemia,
• hypertriglyceridemia,
• cov pab pawg muaj kev pheej hmoo rau kev txhim kho tus mob plawv (cov neeg laus dua 55 xyoo, haus luam yeeb, cov neeg mob ntshav qab zib mellitus, mob muaj keeb tiv, ntshav siab thiab lwm tus),
• mob plawv plawv.

Koj tuaj yeem txo cov roj cholesterol, soj ntsuam kev noj zaub mov zoo, kev tawm dag zog, nrog kev rog dhau los ntawm kev tso cov roj hauv lub cev ntau dhau, yog tias cov yeeb yam no tsis muab cov txiaj ntsig, tso cov tshuaj uas txo cov roj cholesterol.

Nws yog ib qho tsim nyog kom ua raws li cov lus qhia rau kev siv Liprimar. Nws tsis muaj sijhawm txwv los siv ntawm kev noj tshuaj. Raws li cov ntsuas ntawm LDL (cov teeb meem roj cholesterol), txhua hnub tshuaj ntawm cov tshuaj (feem ntau 10-80 mg) tau xam. Tus neeg mob nrog rau thawj daim ntawv ntawm hypercholesterolemia los yog sib xyaw ua ke hyperlipidemia yog tau txhaj 10 mg, noj txhua hnub rau 2-4 lub lis piam. Cov neeg mob uas tau los ntawm keeb kwm hypercholesterolemia raug kho ntau tshaj 80 mg.

Xaiv cov koob tshuaj uas cuam tshuam rau cov rog rog yuav tsum raug tswj los ntawm qib lipid hauv cov ntshav.

Nrog kev ceev faj, cov tshuaj yog tawm rau cov neeg mob uas lub siab tsis ua haujlwm lossis muaj kev sib xyaw nrog Cyclosparin (tsis ntau tshaj 10 mg rau ib hnub), muaj kev txom nyem los ntawm cov kab mob hauv lub raum, cov neeg mob uas muaj hnub nyoog txwv tsis tas yuav siv.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj, hauv lub hlwv ntawm 7-10 pieces, tus naj npawb ntawm cov hlwv hauv pob kuj tseem sib txawv, ntawm 2 txog 10.Cov tshuaj tseem ceeb yog calcium ntsev (atorvastatin) thiab cov tshuaj ntxiv: croscarmellose sodium, calcium carbonate, candelila ciab, me muaju ntawm cellulose, hyprolose, lactose monohydrate, polysorbate-80, opadra dawb, magnesium stearate, simethicone emulsion.

Elliptical Liprimar ntsiav tshuaj coated nrog lub plhaub dawb, nyob ntawm seb qhov ntau npaum li cas hauv milligrams, muaj engraving ntawm 10, 20, 40 lossis 80.

Cov khoom tseem ceeb

Cov cuab yeej tseem ceeb ntawm Liprimar yog nws cov hypolipidemia. Cov tshuaj yaj yeeb pab txo qis zus tau cov cov enzymes ua lub luag haujlwm ntawm cov roj (cholesterol). Qhov no ua rau muaj kev txo qis hauv cov roj los ntawm daim siab los ntawm lub siab, feem, nws qib hauv cov ntshav txo qis, thiab kev ua haujlwm ntawm cov hlab ntaws zoo tuaj.

Cov tshuaj yog tawm rau cov neeg uas muaj hypercholesterolemia, kev noj zaub mov tsis zoo tshuaj thiab lwm cov tshuaj txo cov rog. Tom qab kawm tiav ntawm kev kho, cov qib roj cholesterol poob los ntawm 30-45%, thiab LDL - los ntawm 40-60%, thiab cov lipoprotein ntau hauv cov ntshav nce ntxiv.

Kev siv Liprimar pab txo kev txhim kho kev mob plawv txog 15%, kev tuag ntawm kev mob plawv poob qis, thiab kev pheej hmoo ntawm lub plawv nres thiab muaj kev phom sij rau lub plawv nres tsawg dua 25%. Mutagenic thiab carcinogenic cov yam ntxwv tsis tau pom.

Phiv los ntawm Liprimara

Zoo li txhua yam tshuaj, qhov no muaj kev phiv. Rau Liprimar, cov lus qhia rau kev siv qhia tau tias nws feem ntau zoo rau ua. Txawm li cas los xij, ib tug xov tooj ntawm cov kev mob tshwm sim tau qhia: insomnia, mob ntev nkees syndrome (asthenia), mob taub hau hauv plab, raws plab thiab dyspepsia, tsam plab (mob plab) thiab cem quav, myalgia, xeev siab.

Cov tsos mob ntawm tus mob anaphylaxis, anorexia, mob pob txaws, mob leeg thiab mob rwj, hypo- lossis hyperglycemia, kiv taub hau, daj ntseg, tawv nqaij tawm pob, khaus, urticaria, myopathy, tsis nco qab, poob qis los yog nce rhiab, neuropathy, pancreatitis, paug, ntuav yog tsis tshua pom. thrombocytopenia.

Cov kev mob tshwm sim los ntawm Liprimar kuj tseem pom, xws li kev o ntawm kev sib txuam, kev rog, mob hauv siab, alopecia, tinnitus, thiab kev txhim kho ntawm cov ua haujlwm hauv lub raum ua tsis tiav.

Lus Tshaj Tawm

Atorvastatin - ib qho tshuaj ntawm Liprimar - yog ib hom tshuaj uas nrov tshaj plaws rau kev txo qis lipoproteins tsawg. Kev ntsuam xyuas los ntawm Grace thiab 4S tau qhia txog kev ua kom zoo dua ntawm atorvastatin dhau simvastatin hauv kev tiv thaiv kev txhim kho ntawm txoj kev xoom xaim kev noj qab haus huv thiab mob stroke. Hauv qab no peb xav txog cov tshuaj ntawm pawg statin.

Atorvastatin-raws li cov khoom lag luam

Cov lus sib piv Lavxias ntawm Liprimar, Atorvastatin, yog tsim los ntawm cov tuam txhab kws kho mob: Kanofarma Ntau lawm, ALSI Pharma, Vertex. Qhov ncauj ntsiav tshuaj nrog qhov ntau npaum ntawm 10, 20, 40 lossis 80 mg. Noj ib zaug ib hnub nyob rau tib lub sijhawm, tsis hais noj mov dabtsi.

Feem ntau cov neeg siv khoom nug lawv tus kheej - Atorvastatin lossis Liprimar - uas yog qhov zoo dua?

Cov nyhuv tshuaj ntawm "Atorvastatin" zoo ib yam li kev ua ntawm "Liprimar", vim tias cov tshuaj nyob rau hauv lub hauv paus muaj tib lub zog tshuaj. Cov txheej txheem ntawm kev ua ntawm thawj cov tshuaj yog tswj kom muaj kev cuam tshuam kev coj ua ntawm cov roj (cholesterol) thiab atherogenic lipoproteins los ntawm lub cev lub cev. Kev siv cov roj LDL hauv lub siab ua haujlwm nce siab, thiab tus nqi ntawm kev tsim tawm ntawm anti-atherogenic high-density lipoproteins kuj nce me ntsis.

Ua ntej kev teem sij hawm ntawm Atorvastatin, tus neeg mob tau kho kom haum rau kev noj zaub mov noj thiab teem ib chav muaj kev tawm dag zog, nws tshwm sim uas qhov no twb coj tau qhov txiaj ntsig zoo, tom qab ntawv kho cov statins yuav tsis tsim nyog.

Yog tias nws tsis tuaj yeem ua kom lub cev sawv cev hauv qib siab nrog cov tshuaj tsis yog siv tshuaj, cov tshuaj ntawm ib pawg loj ntawm cov tshuaj statins raug xaj, uas suav nrog Atorvastatin.

Thaum pib theem ntawm kev kho mob, Atorvastatin raug xaj 10 mg ib hnub ib zaug. Tom qab 3-4 lub lis piam, yog tias qhov tshuaj xaiv tau xaiv qhov raug, kev hloov ntawm lipid spectrum yuav pom tau.Hauv cov lipid profile, qhov kev txo qis ntawm cov roj (cholesterol) tag nrho raug sau tseg, qib qis lipoproteins tsawg tsawg thiab qhov qis, qhov qis ntawm triglycerides tsawg dua.

Yog hais tias theem ntawm cov tshuaj no tsis tau hloov lossis tseem nce ntxiv, nws yog qhov tsim nyog los kho qhov tshuaj ntawm Atorvastatin. Txij li cov tshuaj muaj nyob hauv ntau qhov ntau, nws yooj yim heev rau cov neeg mob hloov nws. 4 lub lis piam tom qab nce qhov koob tshuaj, lipid spectrum tsom xam yog rov ua dua, yog tias tsim nyog, qhov koob tshuaj tau nce dua, qhov siab tshaj plaws niaj hnub noj yog 80 mg.

Tus txheej txheem ntawm kev ua, kev haus tshuaj thiab kev mob tshwm sim ntawm Liprimar thiab nws cov neeg Lavxias yog tib yam. Qhov zoo ntawm Atorvastatin suav nrog nws cov nqi pheej yig dua. Raws li kev txheeb xyuas, cov tshuaj Lavxias feem ntau ua rau muaj kev phiv thiab ua xua piv nrog Liprimar. Thiab lwm qhov tsis txaus ntseeg yog kev kho mus sij hawm ntev.

Lwm yam kev hloov rau Liprimar

Atoris - ib qho analogue ntawm Liprimar - tshuaj tsim los ntawm lub tuam txhab Slovenian tshuaj KRKA. Nws tseem yog hom tshuaj uas zoo sib xws hauv nws txoj haujlwm pharmacological rau Liprimaru. Atoris yog muaj nrog qhov ntau dua qhov tau muab ntau piv rau Liprimar. Qhov no tso cai rau tus kws kho mob laij cov tshuaj ntau dua, thiab tus neeg mob tau yooj yim noj tshuaj.

Atoris tsuas yog tib qho tshuaj feem ntau (Liprimara generic) uas tau dhau los ntau qhov kev sim tshuaj mob thiab tau ua pov thawj nws cov hauj lwm zoo. Cov neeg ua haujlwm pab dawb los ntawm ntau lub tebchaws tau koom nrog nws txoj kev kawm. Txoj kev tshawb no tau tshawb raws li cov chaw kho mob thiab cov tsev kho mob. Raws li kev tshawb fawb hauv 7000 cov kev kawm noj Atoris 10 mg rau 2 hlis, txo qis ntawm atherogenic thiab tag nrho cov cholesterol los ntawm 20-25% tau sau tseg. Qhov tshwm sim ntawm kev mob tshwm sim hauv Atoris yog tsawg heev.

Liptonorm yog ib lub tshuaj Lavxias uas normalizes metabolism hauv cov rog hauv lub cev. Cov tshuaj nquag hauv nws yog atorvastine, ib yam khoom muaj nrog hypolipidemic thiab hypocholesterolemic kev txiav txim siab. Liptonorm muaj qhov ntsuas zoo ib yam rau kev siv thiab haus nrog Liprimar, zoo li cov kev mob tshwm sim zoo sib xws.

Cov tshuaj muaj nyob rau hauv tsuas yog ob qhov tshuaj ntawm 10 thiab 20 mg. Qhov no ua rau nws tsis yooj yim rau kev siv los ntawm cov neeg mob kev txom nyem los ntawm cov ntaub ntawv tsis zoo ntawm atherosclerosis, heterozygous tsev neeg hypercholesterolemia, lawv yuav tsum noj 4-8 ntsiav tshuaj ib hnub, txij li kev siv tshuaj txhua hnub yog 80 mg.

Torvacard yog lub tshuaj yeeb yaj kiab uas nto moo tshaj plaws ntawm Liprimar. Ua cov tuam txhab tshuaj Slovak "Zentiva". "Torvacard" tau tsim nws tus kheej kom zoo rau kev kho cov roj (cholesterol) hauv cov neeg mob kev txom nyem los ntawm cov kab mob plawv. Nws tau ua tiav yog siv los kho cov neeg mob nrog cerebrovascular thiab kev mob ntshav siab tsis txaus, nrog rau kev tiv thaiv ntawm cov teeb meem xws li mob stroke thiab lub plawv nres. Cov tshuaj ua rau txo qis ntawm cov triglycerides hauv cov ntshav. Nws tau ua tiav yog siv los kho cov mob muaj keeb ntawm dyslipidemia, piv txwv li, kom nce qib ntawm "pab" high-density lipoproteins.

Cov ntawv tso tawm ntawm "Torvokard" 10, 20 thiab 40 mg. Atherosclerosis txoj kev kho yog pib, feem ntau nrog 10 mg, tom qab tau kho theem ntawm triglycerides, roj cholesterol, lipoproteins uas tsis muaj ntau. Tom qab 2-4 lub lis piam nqa tawm kev tswj xyuas ntawm lipid spectrum. Nrog kev kho mob tsis ua haujlwm, ntxiv rau kev noj tshuaj. Qhov tshuaj ntau ntau rau ib hnub yog 80 mg.

Tsis zoo li Liprimar, Torvacard zoo dua rau cov neeg mob uas muaj cov kab mob ntawm cov hlab plawv, qhov no yog nws "+".

Rosuvastatin-based khoom

"Rosuvastatin" yog tus neeg sawv cev thib peb uas muaj cov nyhuv lipid. Kev npaj tsim los ntawm nws cov hauv paus yaj tau zoo nyob rau hauv cov kua ua kua ntawm cov ntshav. Lawv cov nyhuv tseem ceeb yog qhov txo qis ntawm tag nrho cov roj (cholesterol) thiab atherogenic lipoproteins. Lwm qhov taw tes zoo, "Rosuvastatin" yuav luag tsis muaj kev cuam tshuam ntawm daim siab mob thiab tsis ua rau cov leeg nqaij.Yog li no, statins raws li rosuvastatin tsis tshua muaj kev ua rau muaj teeb meem ntawm daim siab tsis ua hauj lwm, nce siab ntawm transaminases, myositis, thiab myalgia.

Lub ntsiab pharmacological kev ua yog tsom rau kev tsuj cov hluavtaws thiab nce ntxiv kev nthuav dav ntawm atherogenic feem ntawm cov rog. Cov txiaj ntsig ntawm kev kho mob tshwm sim nrawm dua nrog kev kho Atorvastatin, thawj cov txiaj ntsig tau pom los ntawm qhov kawg ntawm thawj lub lim tiam, cov txiaj ntsig siab tshaj plaws tuaj yeem pom ntawm 3-4 lub lis piam.

Cov tshuaj hauv qab no yog xyuas los ntawm rosuvastatin:

• "Crestor" (ntau lawm hauv Great Britain),
• Mertenil (tsim tawm hauv Hungary),
• "Tevastor" (ua hauv Ixayees).

"Crestor" lossis "Liprimar" dab tsi los xaiv? Npaj yuav tsum tau xaiv los ntawm tus kws kho mob tuaj koom.

Simvastatin-based khoom

Lwm qhov nrov lipid-txo cov tshuaj yog Simvastatin. Raws li nws, ntau cov tshuaj tau tsim cov khoom siv tau zoo los kho tus mob atherosclerosis. Soj ntsuam kev sim ntawm cov tshuaj no, tau ua ntau dua tsib xyoos thiab koom nrog ntau dua 20,000 tus neeg, tau pab txhawm rau txiav txim siab tias simvastatin-raws li cov tshuaj txo qis kev pheej hmoo ntawm lub plawv thiab mob hlab ntsha hauv cov neeg mob uas mob plawv thiab mob hlwb.

Cov tshuaj ntawm Liprimar raws li simvastatin:

• Vasilip (tsim nyob rau hauv Slovenia),
• "Zokor" (ntau lawm - Netherlands).

Ib qho kev txiav txim siab cuam tshuam rau kev yuav ib qho tshuaj tshwj xeeb yog tus nqi. Qhov no kuj siv rau cov tshuaj uas thim rov qab kev cuam tshuam ntawm cov rog metabolism. Kev kho cov mob zoo li no yog tsim los rau ntau lub hlis, thiab qee xyoo. Tus nqi rau cov tshuaj zoo ib yam hauv cov chaw muag tshuaj txawv ntawm cov tuam txhab muag tshuaj ntawm qee lub sijhawm vim tias cov nqi sib txawv ntawm cov cai ntawm cov tuam txhab no. Kev teem caij cov tshuaj thiab xaiv cov tshuaj yuav tsum tau nqa los ntawm tus kws kho mob, txawm li cas los xij, tus neeg mob muaj kev xaiv tshuaj los ntawm ib pawg pharmacological, uas sib txawv hauv cov chaw tsim khoom thiab tus nqi.

Tag nrho cov saum toj no hauv tsev thiab txawv teb chaws, Liprimar hloov chaw, tau dhau los hauv kev kuaj mob hauv tsev kho mob thiab tau tsim lawv tus kheej los ua cov neeg sawv cev uas ua haujlwm ntawm cov rog rog. Cov txiaj ntsig zoo nyob rau hauv daim ntawv ntawm cov roj (cholesterol) tsawg dua pom nyob hauv 89% ntawm cov neeg mob nyob hauv thawj lub hlis ntawm kev kho mob.

Qhov phom sij ntawm cov roj (cholesterol) siab nyob hauv nws qhov kev tsis pom kev. Qhov tso nyiaj tsawg kawg ntawm cov plahaum roj av tuaj yeem kuaj pom tom qab 20 xyoo. Thiab thaum cov tsos mob tshwm sim - ntawm 40, 50, 60 xyoo - cov plaques no ntau dua kaum ob xyoos. Tab sis ib tus neeg uas tau pom ib qho teeb meem - mob plawv lossis mob plaque hauv cov hlab ntsha ntawm caj dab, yog qhov xav tsis thoob - thaum kawg, tsis muaj ib yam dab tsi thab nws ua ntej! Nws tsis tau xav tias nws muaj ntshav siab rau lub sijhawm ntev.

Ib txoj hauv kev zoo tshaj plaws hauv cov tshuaj roj tuaj yeem yog statins. Lawv siv, ntxiv rau ib qho txiaj ntsig zoo, yog nrog qee yam kev mob tshwm sim, yog li nws yog ib qho tseem ceeb kom paub yuav ua li cas coj statins kom raug.

Statins ua haujlwm li cas

Hauv khw muag tshuaj, cov tshuaj no hu ua HMG-Co-A reductase inhibitors. Qhov no txhais tau tias cov tshuaj tiv thaiv statin molecule inhibits qhov enzyme. Cov nyhuv no ua rau txo qis cov roj hauv lub hauv paus thiab ua rau kev ua kom sai ntawm cov roj tsawg (qhov phom sij tshaj plaws). Raws li qhov tshwm sim: cov ntshav roj yog txo. Statins ua ncaj qha rau neeg lub siab.

Tsis tas li ntawd, statins muaj qhov ua tawm tsam thiab muaj lub zog antioxidant - qhov no txhais tau hais tias cov tsim cov quav hniav yuav ruaj khov dua thiab tsis zoo li yuav ua rau mob thrombosis (uas yog qhov ua rau mob plawv lossis mob stroke).

Tsuas yog tus kws kho mob uas tuaj koom yuav tsum sau cov tshuaj statin: qee qhov kev mob tshwm sim ntawm statins yog qhov txaus ntshai. Ua ntej pom zoo rau lawv, tus kws kho mob yuav ntsuas txhua qhov ntsuas ntawm kev kuaj ntshav thiab cov kab mob uas twb muaj lawm.

Cov tshuaj ntawm cov tshuaj thiab cov piv txwv ntawm cov ntsiav tshuaj

• Simvastatin yog cov tshuaj qaug zog tshaj plaws.Nws ua rau pom zoo siv nws tsuas yog rau cov neeg uas lawv cov roj (cholesterol) nce siab me ntsis. Cov no yog cov ntsiav tshuaj xws li Zokor, Vasilip, Simvakard, Sivageksal, Simvastol. Lawv muaj nyob rau hauv qhov ntau npaum ntawm 10, 20 thiab 40 mg.
• Atorvastatin muaj zog dua. Nws tuaj yeem siv tau yog tias qib roj hauv siab yog siab. Cov no yog cov ntsiav tshuaj los ntawm cov cholesterol Liprimar, Atoris, Torvakard, Novostat, Liptonorm. Kev noj tshuaj yuav yog 10, 20, 30, 40 thiab 80 mg.
• Rosuvostatin yog qhov muaj zog tshaj plaws. Cov kws kho mob sau nws hauv cov roj (cholesterol) siab, thaum koj xav tau kom txo qis. Cov no yog cov ntsiav tshuaj Krestor, Roxer, Mertenil, Rosulip, Tevastor. Rosucard. Nws muaj cov koob tshuaj nram qab no: 5, 10, 20 thiab 40 mg.
• Lovastatin pom nyob hauv Cardiostatin, Choletar, Mevacor. Cov tshuaj no tsuas yog hauv ib koob tshuaj 20 mg rau ib ntsiav tshuaj.
• Fluvastatin kom deb li deb tsuas muaj ib hom ntsiav tshuaj nkaus xwb - qhov no yog Lescor (20 lossis 40 mg ib qho)

Raws li koj tuaj yeem pom, qhov ntau npaum ntawm cov tshuaj yog qhov zoo sib xws. Tab sis vim tias qhov sib txawv ntawm cov hauj lwm zoo, 10 mg ntawm rosuvostatin qis cov roj cholesterol sai dua 10 mg ntawm atorvastatin. Thiab 10 mg ntawm Atoris zoo tshaj li 10 mg ntawm Vasilip. Yog li, tsuas yog tus kws kho mob tau tuaj yeem sau ntawv rau statins, ntsuas txhua yam cuam tshuam, contraindications thiab qhov ntxim nyiam ntawm kev mob tshwm sim.

Yuav ua li cas coj statins?

Yuav kom txo qis cov cholesterol, cov tshuaj statins tau noj ib hnub ib zaug. Nws zoo dua yog tias nws yuav nyob yav tsaus ntuj - txij li cov lipids tsim kho rau thaum yav tsaus ntuj. Tab sis rau atorvastatin thiab rosuvostatin, qhov no tsis yog qhov tseeb: lawv ua haujlwm sib npaug txhua hnub.

Koj tsis tuaj yeem xav tias yog tias ib tug neeg haus tshuaj uas txo cov roj cholesterol, ces tsis tas noj zaub mov noj yog tsis xav tau. Yog tias tsis muaj dab tsi hauv tus neeg hloov txoj kev ua neej, kev kho mob nrog statins tsis muaj nuj nqis. Kev noj zaub mov kom suav nrog kev txiav luam yeeb thiab haus dej haus cawv, txo cov ntsev ntau hauv cov zaub mov. Cov zaub mov yuav tsum muaj ntau yam, muaj tsawg kawg peb pluag mov ntses ib as thiv thiab 400 g zaub lossis txiv hmab txiv ntoo nyob rau ib hnub. Nws feem ntau lees txais tias tsis muaj dab tsi hauv kev txo cov calories ntau ntawm cov zaub mov yog tias tsis muaj qhov hnyav tshaj.

Kev ua haujlwm qoj ib nrab hauv cov huab cua muaj txiaj ntsig zoo: lawv txhim kho cov mob ntawm cov hlab ntsha. Txog 30-45 feeb 3-4 zaug ib lub lim tiam yuav txaus.

Cov koob tshuaj ntawm statins yog tus kheej, tsuas yog kws kho mob yuav tsum sau nws. Nws tsis yog nyob ntawm cov roj cholesterol nkaus xwb, tab sis kuj yog ua rau tib neeg cov kab mob.

Piv txwv li, tus kws kho mob tau sau 20 mg ntawm Atoris rau koj, thiab tus neeg nyob ze nrog tib co roj av - 10 mg. Qhov no tsis qhia tias tsis paub kev paub tshwj xeeb. Nws tsuas txhais tau hais tias koj muaj cov kabmob sib txawv, yog li qhov koob tshuaj ntawm statins yog qhov sib txawv.

Tus Txheeb Ze contraindications

Statins yog siv nrog ceeb toom:

• Nrog rau daim siab mob uas yog ib zaug.
• Nrog kev ua rog ua rog nrog kev nce me ntsis hauv cov qib ntawm cov enzymes.
• Ntawm hom 2 mob ntshav qab zib mellitus, decompensated thaum muaj suab thaj tsis tswj.
• Cov poj niam nyaum dua 65 xyoo twb tau haus ntau yam tshuaj.

Txawm li cas los xij, nrog ceev faj - tsis txhais tau tias yuav tsis taw.

Tom qab tag nrho, kev siv cov statins los ntawm cov roj (cholesterol) yog tias lawv tiv thaiv ib tus neeg los ntawm cov kab mob xws li myocardial infarction, lub suab sib luag (uas tuaj yeem ua rau mob plawv), mob hlwb, mob ntsws. Cov hom kab mob niaj hnub no ua rau ntau txhiab leej neeg tuag thiab suav hais tias yog ib qhov laj thawj ua rau kev tuag. Tab sis txoj kev pheej hmoo ntawm kev tuag los ntawm cov roj hepatosis yog qhov tsawg.

Yog li, tsis txhob ntshai yog tias koj ib zaug muaj kab mob siab, thiab tam sim no statins yog tshuaj tau. Tus kws kho mob yuav qhia koj kom kuaj ntshav ua ntej noj stats cov roj thiab lwm lub hlis tom qab. Yog hais tias theem ntawm daim siab enzymes nyob rau hauv kev txiav txim, ces nws tuaj yeem lav nrog lub load zoo kawg nkaus, thiab cov roj cholesterol yuav poob qis.

Ua ke nrog lwm cov tshuaj

Cov kev mob tshwm sim los ntawm statins nce ntxiv yog tias lawv tau noj tib lub sijhawm nrog lwm cov tshuaj: thiazide diaretics (hypothiazide), macrolides (azithromycin), calcium antagonists (amlodipine). Koj yuav tsum zam kev tswj hwm tus kheej ntawm cov cai rau cov roj (cholesterol) - tus kws kho mob yuav tsum ntsuas txhua yam tshuaj uas ib tug neeg noj. Nws yuav txiav txim siab seb qhov kev sib txuam no yog sib kis.

Ntev npaum li cas Kuv yuav tsum tau noj statins

Feem ntau cov xwm txheej tshwm sim thaum ib tug neeg haus ib pob ntawm Krestor thiab xav tias tam sim no nws noj qab nyob zoo. Nov yog qhov kev xav tsis raug. Kev nce ntxiv ntawm cov roj (atherosclerosis) yog ib qho mob ntev, nws tsis tuaj yeem kho nws nrog ib pob tshuaj.

Tab sis nws yog qhov tseeb heev txhawm rau tswj cov qib roj cholesterol kom cov plaques tshiab tsis ua, thiab cov qub yuav yaj. Ua qhov no, nws yog ib qho tseem ceeb kom ua raws li kev noj zaub mov noj thiab noj cov tshuaj statins ntev.

Tab sis cov koob tshuaj uas yog Ameslikas - dhau sijhawm, yuav txo qis.

Dab tsi koj yuav tsum tswj hwm yog tias koj haus statins

Thaum kho thiab ua ntej nws pib, cov qib ntawm cov lipids yog ntsuas: tag nrho cov roj (cholesterol), triglycerides thiab cov lipids uas muaj qhov hnyav thiab tsawg tsawg. Yog tias cov qib roj (cholesterol) tsis poob, ces nws muaj peev xwm ntau npaum no. Tus kws kho mob yuav qhia koj kom tsa nws lossis tos.

Txij li cov tshuaj uas cov roj (cholesterol) tsawg ua rau lub siab, koj yuav tsum tau kuaj ntshav biochemical ib zaug kom thiaj txiav txim tau qhov theem ntawm cov ntshav enzymes. Tus kws kho mob uas tuaj koom yuav soj ntsuam qhov no.

• Ua ntej kev teem caij cov tshuaj statins: AST, ALT, KFK.
• 4-6 lub lis piam tom qab pib nkag: AST, ALT.

Nrog rau qhov nce ntxiv ntawm cov kev cai ntawm AST thiab ALT los ntawm ntau dua peb zaug, kev kuaj ntshav yog rov ua dua. Yog tias tib cov txiaj ntsig tau txais thaum kuaj ntshav dua, tom qab ntawd cov statins raug muab tso tseg kom txog rau thaum cov qib ua tus qub. Tej zaum tus kws kho mob yuav txiav txim siab tias cov tshuaj statins tuaj yeem hloov nrog lwm cov tshuaj siv roj (cholesterol).

Kev Cholesterol yog qhov tseem ceeb hauv lub cev. Tab sis nrog nws nce, cov kab mob txaus ntshai tshwm sim. Nws tsis tas yuav tsum kuaj ntshav me me kom tag nrho cov roj (cholesterol). Yog tias, raws li nws cov txiaj ntsig, tus kws kho mob qhia tswv yim kom noj cov tshuaj statins, tom qab ntawd lawv xav tau tiag tiag. Cov tshuaj siv roj (cholesterol) no muaj qhov ua tau zoo heev, tab sis muaj ntau cov kev phiv. Yog li, nws yog nruj me ntsis txwv tsis pub haus lawv yam tsis muaj kev pom zoo los ntawm kws kho mob.

Statins: lawv ua li cas, kev ntsuas thiab contraindications, tshuaj xyuas tshuaj, dab tsi los hloov

Cov roj (cholesterol), lossis cov roj cholesterol yog ib yam khoom uas ua haujlwm tseem ceeb hauv tib neeg lub cev. Cov no suav nrog:

• Kev koom tes ua cov khoom siv hauv tsev hauv cov txheej txheem lub neej ntawm yuav luag txhua lub hlwb ntawm lub cev, vim tias cov roj (molecules) cov roj (cholesterol) nyob rau hauv cov cell ua rau lub cev ua rau nws muaj zog, ua tau yooj yim thiab “muaj txiaj ntsig”,
• Kev koom tes hauv cov txheej txheem kev zom thiab tsim kom muaj cov kua tsib cov acids uas tsim nyog rau kev tawg thiab nqus ntawm cov rog hauv cov hnyuv,
• Kev koom tes hauv kev tsim cov tshuaj hormones hauv lub cev - cov tshuaj hormones steroid ntawm cov qog adrenal thiab cov tshuaj hormones poj niam txiv neej.

Cov roj (cholesterol) ntau dhau hauv cov ntshav ua rau qhov tseeb tias nws cov lwg me me uas tau muab tso rau ntawm phab ntsa ntawm cov hlab ntsha (feem ntau yog cov hlab ntsha). Atherosclerotic plaques yog tsim los cuam tshuam cov ntshav ntws los ntawm cov leeg thiab qee zaum, ua ke nrog cov ntshav txhaws nrog lawv, ua tiav lumen ntawm cov hlab ntsha, pab txhawb kev txhim kho lub plawv thiab mob hlab ntsha tawg.

Cov cai ntawm cov roj (cholesterol) tag nrho hauv cov ntshav ntawm tus neeg laus yuav tsum tsis pub ntau dua 5.0 mmol / l, hauv cov neeg mob mob plawv tsis pub tshaj 4,5 mmol / l, thiab hauv cov neeg mob myocardial infarction tsis pub tshaj 4.0 mmol / l.

Dab tsi yog statins thiab lawv ua haujlwm li cas?

Hauv qhov xwm txheej uas tus neeg mob tau muaj kev pheej hmoo ntawm kev tsim cov myocardial infarction vim yog atherosclerosis thiab cov roj metabolism hauv lub cev tsis txaus siab, nws tau pom tias siv tshuaj lipid-txo cov tshuaj ntev ntev.

Statins yog hypolipidemic (lipid-txo qis) cov tshuaj, cov txheej txheem ntawm kev txiav txim ntawm uas yog txhawm rau enzyme uas txhawb nqa kev tsim cov roj (cholesterol). Lawv ua haujlwm rau lub hauv paus ntsiab lus ntawm "tsis muaj enzyme - tsis muaj roj". Tsis tas li ntawd, vim muaj cov txheej txheem ncaj qha, lawv pab txhawb kev txhim kho ntawm cov txheej hauv cov hlab ntshav ntawm theem thaum cov kab mob atherosclerosis tseem tsis tuaj yeem kuaj mob, tab sis kev ua haujlwm ntawm cov cholesterol nyob ntawm phab ntsa yog twb pib - ntawm theem pib ntawm atherosclerosis.Lawv kuj muaj cov txiaj ntsig zoo ntawm rheological yam ntxwv ntawm cov ntshav, txo viscosity, uas yog qhov tseem ceeb uas tiv thaiv kev tsim cov ntshav txhaws thiab lawv txuas rau cov quav hniav.

Kev ua tau zoo tshaj plaws tam sim no tau lees paub tias yog qhov tseeb tshaj plaws ntawm statins, uas muaj atorvastatin, cerivastatin, rosuvastatin thiab pitavastatin yog cov tshuaj nquag. Cov tshuaj ntawm cov tub ntxhais tiam tam sim no tsis tsuas yog txo cov theem "phem" cov roj cholesterol, tab sis kuj nce cov ntsiab lus ntawm "zoo" hauv cov ntshav. Cov no yog cov statins zoo tshaj plaws rau hnub tim, thiab cov txiaj ntsig ntawm lawv txoj kev siv txhim kho twb tau nyob hauv thawj lub hlis ntawm kev siv tas mus li. Statins yog tau sau tseg ib hnub ib hmos thaum tsaus ntuj, kev sib txuam ntawm lawv hauv ib ntsiav tshuaj nrog lwm cov tshuaj mob plawv yog ua tau.

Kev siv ywj pheej ntawm cov tshuaj statins yam tsis tau sab laj nrog kws kho mob yog qhov tsis tuaj yeem tsis tau, txij li ua ntej noj tshuaj nws yog qhov tsim nyog los txiav txim siab txog qib roj hauv cov ntshav. Ntxiv mus, yog tias cov qib roj cholesterol tsawg dua 6.5 mmol / l, tsis pub dhau rau lub hlis koj yuav tsum sim txo nws nrog zaub mov noj, muaj kev noj qab haus huv, thiab tsuas yog tias cov kev ntsuas no tsis muaj txiaj ntsig, tus kws kho mob txiav txim siab txog kev teem caij statins.

Los ntawm cov lus qhia rau kev siv statins, koj tuaj yeem hais lub ntsiab lus tseem ceeb:

Kev ntsuas rau statins

Lub ntsiab tseem ceeb yog hypercholesterolemia (cov roj (ntshav siab)) nrog qhov tsis muaj txiaj ntsig ntawm txoj kev tsis siv tshuaj yaj yeeb thiab tsev neeg (mob) hypercholesterolemia nrog qhov tsis muaj txiaj ntsig ntawm kev noj haus.

Kho cov tshuaj statins yog qhov yuav tsum tau ua rau cov neeg muaj hypercholesterolemia cuam tshuam nrog cov kab mob hauv qab no, txij li lawv siv nrog lwm cov tshuaj uas kws kho mob ua rau txo qis kev pheej hmoo sai sai:

• Cov neeg laus dua 40 nrog qhov muaj feem yuav muaj kab mob plawv heev,
• Kab mob rau lub plawv, angina pectoris,
• Myocardial infarction
• Aorto-coronary bypass phais los yog stent tso rau myocardial ischemia,
• Mob stroke
• Kev pham
• Mob ntshav qab zib mellitus
• Tus neeg mob cia li tuag tam sid hauv cov neeg txheeb ze hauv qis dua 50 xyoo.

Statins tuaj yeem ua ke nrog lwm cov tshuaj?

Raws li cov lus pom zoo ntawm WHO thiab American Heart Association, statins yog cov tshuaj tseem ceeb hauv kev kho cov mob plawv nrog cov kev pheej hmoo ntawm cov teeb meem thiab myocardial infarction. Kev muab tshuaj ib leeg los txo cov roj (cholesterol) tsis txaus, yog li cov tshuaj tseem ceeb muaj nyob hauv cov qauv kev kho mob - cov no yog beta - blockers (bisoprolol, atenolol, metoprolol, thiab lwm yam), cov tshuaj tiv thaiv kab mob antiplatelet (tshuaj aspirin, tshuaj aspirin Cardio, tshuaj aspicor, thrombo Ass, thiab lwm yam), ACE inhibitors ( enalapril, perindopril, quadripril, thiab lwm yam) thiab statins. Ntau cov kev tshawb fawb tau ua uas tau pom tseeb tias kev siv cov tshuaj no ua ke yog kev nyab xeeb. Ntxiv mus, nrog kev sib xyaw ntawm, piv txwv li, pravastatin thiab cov tshuaj aspirin hauv ib ntsiav tshuaj, qhov kev pheej hmoo ntawm kev txhim kho myocardial infarction (7.6%) tau txo qis piv rau kev siv tshuaj ib leeg (yuav luag 9% thiab 11% thaum noj pravastatin thiab tshuaj aspirin, feem).

Yog li, yog tias statins tau sau tseg nyob rau hmo ntuj ua ntej, uas yog, thaum lub sijhawm sib cais los ntawm kev noj lwm yam tshuaj, lub ntiaj teb kev kho mob hauv zej zog tam sim no txiav txim siab tias kev noj tshuaj sib xyaw ua ke hauv ib ntsiav tshuaj yog qhov zoo dua. Ntawm cov kev sib txuam no, cov tshuaj hu ua polypill yog tam sim no tau sim, tab sis lawv qhov kev siv ntau tseem nyob hauv kev txwv. Twb tau ua tiav cov tshuaj siv nrog kev sib txuam ntawm atorvastatin thiab amlodipine - caduet, duplexor.

Nrog theem siab ntawm cov roj (ntau dua li 7.4 mmol / l), kev siv cov tshuaj statins nrog cov tshuaj muaj peev xwm txo nws los ntawm lwm pab pawg - fibrates. Kev teem caij no tsuas yog ua los ntawm kws kho mob, ua tib zoo ntsuas kev pheej hmoo ntawm kev phiv.

Koj tsis tuaj yeem ua ke noj kev noj haus statins nrog kua txiv kab ntxwv qaub, vim nws muaj cov tshuaj uas ua rau cov metabolism hauv cov kab mob qis rau hauv lub cev thiab nce lawv cov kev xav hauv cov ntshav, uas yog fraught nrog txoj kev txhim kho cov kev phiv tshuaj lom.

Tsis tas li, koj yuav tsum tsis txhob noj cov tshuaj no nrog cawv, tshuaj tua kab mob, tshwj xeeb yog clarithromycin thiab erythromycin, vim tias qhov no tuaj yeem ua rau muaj kev phiv rau daim siab. Lwm cov tshuaj tua kab mob ua ke nrog cov tshuaj txo cov roj cholesterol kom zoo. Yuav kom ntsuam xyuas lub siab ua haujlwm, nws yog ib qho tsim nyog yuav tsum tau kuaj ntshav biochemical kuaj txhua peb lub hlis thiab txiav txim siab txog qib siab ntawm daim siab (AlAT, AsAT).

Kev phom sij thiab txiaj ntsig - Pros thiab Cons

Thaum noj tshuaj uas kws kho mob sau tseg, tus neeg mob twg xav txog qhov tseeb ntawm cov tshuaj. Kev noj cov tshuaj statins tsis muaj kev zam, tshwj xeeb yog vim qhov tseeb tias koj tuaj yeem hnov ​​feem ntau txog kev phom sij ntawm cov tshuaj no. Qhov kev pom no tuaj yeem tshem tawm, vim tias xyoo tsis ntev los no cov tshuaj kho tshiab tau tsim kho uas coj ntau cov txiaj ntsig dua li kev tsim txom.

Kev xaiv ntawm cov qauv ntau thiab thawj

Cov tshuaj Torvakard yog ib qho tseem ceeb tshaj plaws ntawm Atorvastatin.

Nws tus nqi yog ib nrab ntawm qhov uas ua rau ntau tus neeg nyiam, vim tias cov nyiaj khaws cia yog 50%. Nws tau zoo tshaj tawm, muaj kev txheeb xyuas zoo txog nws, yog li neeg coj nws nrog kev txaus siab.

Cov tshuaj sib txawv heev nyob rau hauv muaj pes tsawg leeg, yog tias nyob rau hauv thawj daim ntawv qhia muaj tsuas yog thawj cov tshuaj atorvastatin thiab kev pabcuam hauv daim ntawv ntawm lactose, tom qab ntawd hauv Torvakard muaj ntau lub koomhaum pabcuam ntxiv.

Cov tshuaj muaj pes tsawg leeg suav nrog:

1. Atorvastatin calcium ntsev, 10 milligrams - cov tshuaj nquag,
2. Croscarmellose sodium - ib qho tsis sib haum xeeb uas muab cov tshuaj qhuav hauv plab tshem tawm,
3. Magnesium oxide tiv thaiv clumping,
4. Lactose monohydrate - muab tub lim rau kis tau los ntawm qhov ntau txaus,
5. Monocrystalline kua nplaum yog qhov tsw thiab qhov tsw tsw,
6. Magnesium stearate yog cov khoom coj los tiv thaiv cov khoom ua kom yooj yim rau kev tsim khoom thiab ntim.

Muaj pes tsawg leeg lub plhaub taum muaj xws li:

• titanium dioxide - cov ntxhia ntxhia hauv cov roj nplua,
• talc yog cov tshuaj txav tawm uas txo qhov ntxhib vim kev adsorption nyob rau saum npoo ntawm granules.

Raws li tuaj yeem pom los ntawm cov keeb kwm yav dhau los, cov tshuaj Torvakard muaj ntau yam phom sij uas ua rau hnyav nce thiab nws cov khoom siv lub cev. Rau ntau yam ntawm cov khoom no, kev tsis haum tshuaj tiv thaiv kab mob tuaj yeem tsim kev tsis haum lossis kev tawm tsam ntawm kev tsis haum, suav txij li khaus ntawm daim tawv nqaij mus rau Quincke's edema, yog li lawv tsis pom zoo kom siv cov tshuaj. Lossis, ntsuas uantej nrog kev sim tshuaj allergenic rau cov khoom sib txuas no kom ntseeg tau tias kev noj tshuaj kom zoo rau kev nyab xeeb.

Cov neeg uas mob tsis haum mis nyuj yog txwv tsis pub noj yam tshuaj muaj sia txhua yam.

Yog li dab tsi yog qhov txawv ntawm Atorvastatin thiab Torvacard?

Raws li tuaj yeem pom los ntawm cov kev tshawb fawb soj ntsuam, kev tsom xam cov sib xyaw molecular thiab kev phom sij tsis haum, Torvacard yog qis dua me ntsis ntawm Atorvastatin. Qhov no tsis yog qhov xav tsis thoob, vim hais tias cov thev naus laus zis rau kev tsim cov generics txawv ntawm qhov qub, yog li ntawd, cov nyhuv tshuaj kho tau qis dua, thiab qhov yuav tsum tau siv tshuaj ntau dua. Nws cov txiaj ntsig tseem ceeb yog tus nqi, tab sis nws tsim nyog nco ntsoov tias avaricious them ob zaug, thiab koj yuav tsum twv yuav raug tsis txuag ntawm koj kev noj qab haus huv.

Nws puas tsim nyog nws coj cov neeg txawj ntse statins yuav qhia hauv qhov yeeb yaj kiab hauv tsab xov xwm no.

• Stabilizes qib qab zib kom ntev
• Rov kho cov tshuaj insulin pancreatic

Cov txiaj ntsig ntawm kev noj cov statins

1. 40% yuav txo tau kev tuag nyob hauv thawj tsib xyoos,
2. 30% txo nyob rau hauv kev pheej hmoo ntawm mob hlab ntsha tawg thiab plawv nres,
3. Kev ua kom tau zoo - txo qis roj nrog qhov siv tas li los ntawm 45 - 55% ntawm thawj theem. Txhawm rau kom ntsuas qhov ua tau zoo, tus neeg mob yuav tsum kuaj ntshav txhua lub hlis txhawm rau cov cholesterol,
4. Kev Nyab Xeeb - noj cov tshuaj tshiab kawg ntawm statins hauv kev siv tshuaj tsis muaj tshuaj lom neeg tsis zoo rau tus neeg mob lub cev, thiab txoj kev pheej hmoo ntawm kev phiv yog tsawg heev. Ntau cov kev tshawb fawb uas tau ua lub sijhawm ntev los saib xyuas cov neeg mob uas tau noj cov tshuaj statins rau lub sijhawm ntev tau qhia tias lawv txoj kev siv yuav ua rau kev loj hlob ntawm hom 2 mob ntshav qab zib mellitus, mob qog mob cancer, cataracts, thiab puas hlwb. Txawm li cas los xij, qhov no tau pom zoo thiab ua pov thawj tias cov kabmob zoo li no tau pib vim lwm yam. Ntxiv mus, kev soj ntsuam hauv Denmark ntawm cov neeg mob uas muaj ntshav qab zib hom 2 mellitus uas twb muaj lawm txij li xyoo 1996 tau qhia tias qhov kev pheej hmoo ntawm kev tsim muaj cov ntshav qab zib muaj teeb meem xws li mob ntshav qab zib polyneuropathy, retinopathy raug txo los ntawm 34% thiab 40%, feem.
5. Coob tus naj npawb ntawm cov tshuaj yeeb yaj kiab nrog ib qho tshuaj yeeb yam hauv cov nqi sib txawv, uas pab xaiv cov tshuaj noj mus rau hauv tus account lub peev nyiaj ntawm tus neeg mob.

Qhov tsis zoo ntawm kev noj cov tshuaj statins

• Tus nqi siab ntawm qee qhov kev npaj ua ntej (Hla, rosucard, leskol forte). Hmoov zoo, qhov tsis zoo no tau yooj yim tshem tawm thaum hloov cov tshuaj nrog tib cov tshuaj muaj yees nrog tus qub pheej yig dua.

Yog lawm, qhov zoo thiab cov txiaj ntsig tsis paub yuav tsum tau coj mus rau hauv tus neeg mob uas muaj qhov taw qhia rau kev nkag mus, yog tias nws xav tias nws muaj kev nyab xeeb los noj statins thiab ua tib zoo ntsuas qhov zoo thiab qhov tsis zoo.

Saib txog tshuaj

Cov npe ntawm cov tshuaj uas feem ntau siv rau cov neeg mob tau hais hauv lub rooj:

Lub npe ntawm cov tshuaj, cov ntsiab lus ntawm cov tshuaj nquag (mg)

Tus nqi kwv yees, rub

Kuv tiam SimvastatinVasilip (10, 20 lossis 40)Slovenia355 — 533 Simgal (10, 20 lossis 40)Czech koom pheej, Ixayees311 — 611 Simvakard (10, 20, 40)Czech koom pheej262 — 402 Simlo (10, 20, 40)Is Nrias teb256 — 348 Simvastatin (10, 20 lossis 40)Serbia, Russia72 — 177 PravastatinLipostat (10, 20)Russia, Tebchaws Asmeskas, Ltalis143 — 198 LovastatinHolletar (20)Slovenia323 Cardiostatin (20, 40)Lavxias244 — 368 Tiam II FluvastatinLeskol Forte (80)Switzerland, Spain2315 III tiam AtorvastatinLiptonorm (20)Is Nrias teb, Russia344 Liprimar (10, 20, 40, 80)Lub teb chaws Yelemees, USA, Ireland727 — 1160 Torvacard (10, 40)Czech koom pheej316 — 536 Atoris (10, 20, 30, 40)Slovenia, Russia318 — 541 Tulip (10, 20, 40)Slovenia, Sweden223 — 549 IV tiam RosuvastatinCrestor (5, 10, 20, 40)Russia, Great Britain, Lub Tebchaws Yelemees1134 – 1600 Rosucard (10, 20, 40)Czech koom pheej1200 — 1600 Rosulip (10, 20)Hungary629 – 913 Tevastor (5, 10, 20)Ixayees383 – 679 PitavastatinLivazo (1, 2, 4 mg)Ltalis2350

Txawm hais tias xws li kev nthuav dav dav hauv tus nqi ntawm statins, pheej yig dua analogues tsis ntau qis dua rau cov tshuaj kim. Yog li, yog tias tus neeg mob tsis tuaj yeem yuav cov tshuaj kho mob thawj zaug, nws muaj peev xwm hloov tau nws raws li kws kho mob tau sau nrog qhov zoo sib xws thiab pheej yig dua.

Kuv tuaj yeem txo qis kuv cov roj (cholesterol) yam tsis muaj tshuaj?

Hauv kev kho mob ntawm atherosclerosis raws li kev nthuav qhia cov roj "tsis zoo" hauv lub cev, thawj cov tshuaj yuav tsum pom zoo rau kev txhim kho kev ua neej, vim tias yog tias cov qib roj cholesterol tsis siab dhau (5.0 - 6.5 mmol / l), thiab kev pheej hmoo ntawm cov teeb meem mob plawv tseem qis, koj tuaj yeem sim normalize nws nrog kev pab los ntawm cov kev ntsuas:

Qee cov khoom noj muaj cov khoom tseem ceeb. Ntawm cov khoom lag luam no, qej thiab turmeric yog qhov kev kawm tshaj plaws. Ntses roj npaj muaj omega 3 fatty acids uas yog, uas pab cov roj metabolism hauv lub cev tsis zoo. Koj tuaj yeem nqa cov roj ntses uas yuav hauv khw muag tshuaj, lossis koj tuaj yeem noj cov ntses tais ntses (trout, salmon, salmon, thiab lwm yam) ob zaug ntawm ib lub lim tiam. Cov khoom noj muaj txiaj ntsig ntawm cov zaub fiber ntau, uas tau pom hauv txiv apples, carrots, cereals (oatmeal, barley) thiab legumes, tau txais tos.

Thaum tsis muaj cov nyhuv ntawm cov tshuaj tsis siv tshuaj, tus kws kho mob sau ib qho ntawm cov roj lipid.

Hauv kev xaus, Kuv xav nco ntsoov tias, txawm tias muaj kev ntshai ntawm cov neeg mob thiab lub tswv yim ntawm cov kev phom sij ntawm statins, lawv lub hom phiaj tsuas yog ua kom zoo rau cov kev mob atherosclerosis nyob deb nrog kev puas tsuaj rau cov hlab ntshav ntawm cov hlab ntshav, vim tias cov tshuaj no muaj sia nyob ntev. Yog tias koj muaj cov ntshav siab cov ntshav siab tsis muaj cov cim pib ntawm kev puas tsuaj rau vascular, tom qab ntawd koj yuav tsum noj zaub mov zoo, ua kom nquag plias, ua lub neej zoo, thiab yav tom ntej koj tsis tas yuav xav txog seb yuav noj cov tshuaj statins li cas.

Tau Atoris ntsiav tshuaj noj tau ntev?

Yog lawm, txhua yam statins yog tsim los kom ntev (nrog rau kev rau lub neej ntev). Yog tias nws nyob hauv tus neeg mob tshwj xeeb txo cov roj (cholesterol) thiab tsis ua rau muaj kev nce ntxiv hauv ALT thiab AST (daim siab mob ntshav hauv kev kuaj ntshav), koj tuaj yeem txuas ntxiv. Ntxiv mus, ib zaug txhua rau lub hlis, koj yuav tsum rov ntsuas cov ntshav rau tus lipid profile (roj), ALT, AST.

Yees duab: yog nws ib txwm muaj nqis noj statins?

Kauj Ruam 2: tom qab them nyiaj, nug koj cov lus nug hauv daim ntawv hauv qab no ↓ Kauj Ruam 3: Koj tuaj yeem ntxiv ua tsaug rau tus kws tshaj lij nrog lwm txoj kev them nqi rau tus nqi tsis txaus siab

Swiss cov tshuaj zoo uas tuaj yeem txo LDL li 50%, thiab cov roj cholesterol - los ntawm 40%. Cov nyhuv yog pom tau twb dhau 3 lub lis piam tom qab thov, thiab cov txiaj ntsig siab tshaj plaws tau tiav tom qab ib hlis.

Txoj kev kho mob pib nrog ib koob tshuaj me me ntawm 10 mg ntawm cov tshuaj nquag ib hnub, yog tias tsim nyog nce ntxiv tom qab 3-4 lub lis piam, raws li kev txheeb xyuas ntawm cov ntshav. Ib yam li lwm yam statins, cov neeg mob feem ntau muaj cov kev mob tshwm sim xws li pw tsis tsaug zog, tso quav, thiab leeg tsis muaj zog. Cov nqi rau Swiss Tulip pib los ntawm 255 rubles rau 30 ntsiav tshuaj nrog ntau npaum ntawm 10 mg.

Qhov hloov tshiab tshaj plaws thiab pheej yig dua rau Atoris los ntawm Lavxias chaw tsim tshuaj paus ATOLL. Nws muaj nyob rau hauv daim ntawv ntawm tsiav tshuaj thiab muaj ob peb lwm ntu koom ua ke, uas tso cai rau koj kom ua tiav qhov nrawm dua thiab pom qhov cuam tshuam ntawm kev kho.

Thawj qhov koob tshuaj tseem tsis hloov - 10 mg / hnub. Txawm li cas los xij, ua ntej siv cov tshuaj, nws pom zoo kom hloov mus rau kev noj zaub mov hypocholesterol, uas yuav tsum tau pom thoob plaws hauv tag nrho lub sijhawm kho. Cov nqi rau novostatin pib los ntawm 330 rubles.

Tsis yog qhov pheej yig, tab sis tsis tshua muaj kev nyab xeeb thiab muaj txiaj ntsig zoo, muaj qhov tsawg kawg ntawm cov kev mob tshwm sim, tus neeg Irish. Qhov tseeb, qhov no yog tib yam hypolipidemic thiab hypocholesterolemic tshuaj ntawm lub tuam txhab tshuaj Pfizer, paub txog nws cov cuab yeej tsim khoom siab thiab kev siv cov sib txuas uas maj mam ua rau lub cev, uas yog tshwj xeeb tshaj yog kev kho mob mus ntev. Nyob rau hauv cov ntaub ntawv ntawm cov rog hauv siab, kev kho mob statin tuaj yeem dhau los ntawm ntau lub hlis txog ntau dua ib xyoos.

Nyob rau tib lub sijhawm, muaj qhov cuam tshuam qhov tsis zoo ntawm qhov kev npaj no, uas yog nws tus nqi siab. Cov nqi rau Liprimar hauv cov khw muag tshuaj hauv Lavxias pib ntawm 700 rubles rau 10 ntsiav tshuaj ntawm qhov tshuaj tsawg kawg nkaus.

Tsis tas li ntawd, cov npe ntawm pheej yig dua Atoris analogues tuaj yeem rov ua dua tshiab nrog cov tshuaj uas tsis yog cov neeg paub zoo, tab sis tam sim no nyob rau hauv kev ua lag luam, xws li: Ator, Atomax, Amvastan, Lipoford, Torvalip, Torvas. Nws yog ib qho tseem ceeb kom nco ntsoov txog contraindications, uas yog tib yam rau tag nrho cov tshuaj saud.

Nqe Sib Piv Cov Nqe Lus

Kev suav tshuaj ntawm ib qho yeeb tshuaj yog cov tshuaj hauv ntuj tshiab. Cov nyeem nyeem ntawv pom zoo tshuaj ntuj, uas, ua ke nrog kev noj haus thiab kev ua si, txo qis cov roj (cholesterol) tom qab 3-4 lub lim tiam . Cov tswv yim ntawm cov kws kho mob >>

Tsis hais txog lub tuam txhab tsim khoom thiab ntim, txhua cov tshuaj saum toj no yog ua raws atorvastatin thiab ua zoo ib yam (nrog rau qhov tshwj xeeb ntawm kev sib txawv me me hauv kev phiv, kev nyab xeeb thiab nrawm nkag hauv cov ntshav) - qhov no yog qhov tseeb.

Xws li qhov sib txawv ntawm tus nqi tuaj yeem piav qhia los ntawm tus nqi tsim khoom (qib ntawm cov nyiaj ua haujlwm ntawm cov neeg ua haujlwm, cov nqi ntawm cov khoom siv), cov tsheb thauj mus los thiab cov nuj nqis ntawm lub tuam txhab tshuaj ntawm kev tshaj tawm. Txawm li cas los xij, nws tseem ntseeg tias cov tuam txhab loj thiab muaj npe siv cov cuab yeej tshiab ntau dua thiab tsim cov kev cai siab dua rau kev tsim khoom, vim tias lawv tau txais cov khoom lag luam zoo dua.

Raws li qhov ntau npaum ntawm 10 mg / hnub, ib pob ntawm 30 ntsiav tshuaj yuav txaus rau ib hlis ntawm kev kho mob. Yog tias, tom qab thawj lub hlis ntawm kev kho mob, cov kws kho mob tau tshaj tawm cov txheej txheem statin rau ntau dua 2 hlis, nws yuav tau txais txiaj ntsig ntau los yuav ib pob ntawm 90 lossis 100 ntsiav tshuaj, vim tias tus nqi ntawm ib ntsiav tshuaj hauv cov pob loj yog ntau tsawg.

Pharmacological kev txiav txim

Hluavtaws lipid-txo cov tshuaj. Atorvastatin yog ib qho kev xaiv sib tw muaj zog ntawm HMG-CoA reductase, muaj cov enzyme tseem ceeb uas hloov 3-hydroxy-3-methylglutaryl-CoA rau mevalonate, ua ntej rau steroids, suav nrog cov roj (cholesterol).

Hauv cov neeg mob uas muaj homozygous thiab heterozygous tsev neeg hypercholesterolemia, cov ntaub ntawv tsis muaj tsev neeg ntawm hypercholesterolemia thiab sib xyaw dyslipidemia, atorvastatin txo tag nrho cov roj (Ch) hauv ntshav, ntshav roj-LDL thiab apolipoprotein B (apo-B), thiab tseem ua rau TG-C thiab TG tsis ruaj khov nce hauv qib ntawm HDL-C.

Atorvastatin txo qis kev ua haujlwm ntawm cov roj (cholesterol) thiab lipoproteins hauv ntshav plasma, tiv thaiv HMG-CoA reductase thiab cov roj (cholesterol) ua ke nyob rau hauv daim siab thiab nce cov hepatic LDL receptors nyob rau ntawm tes, uas ua rau muaj kev nce siab thiab catabolism ntawm LDL-C.

Atorvastatin txo qhov tsim ntawm LDL-C thiab tus lej ntawm LDL hmoov. Nws ua rau muaj suab nrov thiab tsis tu ncua nce ntxiv hauv cov dej num ntawm LDL receptors, ua ke nrog cov txiaj ntsig zoo tsim nyog hloov hauv LDL hais. Txo cov theem ntawm LDL-C hauv cov neeg mob homozygous kab mob hypercholesterolemia, tiv taus kev kho mob nrog lwm cov lipid-txo tshuaj.

Atorvastatin hauv koob tshuaj mg txo tag nrho cov roj cholesterol los ntawm 30-46%, LDL-C los ntawm 41-61%, apo-B los ntawm 34-50% thiab TG los ntawm 14-33%. Cov kev kho mob pom tau zoo sib xws hauv cov neeg mob nrog heterozygous tsev neeg hypercholesterolemia, tsis yog tsev neeg cov ntaub ntawv ntawm hypercholesterolemia thiab hyperlipidemia sib xyaw, suav nrog hauv cov neeg mob uas tsis mob ntshav qab zib tsis yog insulin-mellitus.

Hauv cov neeg mob uas muaj tus kabmob hypertriglyceridemia, atorvastatin txo qis tag nrho cov roj, Chs-LDL, Chs-VLDL, apo-B thiab TG thiab nce qib ntawm Chs-HDL. Hauv cov neeg mob dysbetalipoproteinemia, nws txo qis ChS-STD.

Hauv cov neeg mob uas muaj hom IIa thiab IIb hyperlipoproteinemia raws li kev faib tawm Fredrickson, tus nqi nruab nrab ntawm nce HDL-C thaum kho nrog atorvastatin (10-80 mg), piv nrog thawj zaug tus nqi, yog 5.1-8.7% thiab tsis vam khom lub koob tshuaj. Muaj qhov tseem ceeb ntawm qhov txo qis hauv qhov piv: tag nrho cov roj cholesterol / Chs-HDL thiab Chs-LDL / Chs-HDL los ntawm 29-44% thiab 37-55%, feem.

Atorvastatin ntawm koob tshuaj 80 mg txo qhov kev pheej hmoo ntawm ischemic cov teeb meem thiab kev tuag los ntawm 16% tom qab kawm 16-lub lis piam, thiab kev pheej hmoo rov qab pw tsev kho mob rau angina pectoris, nrog cov cim ntawm myocardial ischemia, los ntawm 26%. Hauv cov neeg mob uas muaj qhov sib txawv ntawm qib qis ntawm LDL-C, atorvastatin ua rau txo qis kev pheej hmoo ntawm ischemic nyuaj thiab tuag (hauv cov neeg mob myocardial infarction tsis muaj Q yoj thiab tsis khov, tus txiv neej thiab poj niam, cov neeg mob hnub nyoog qis dua 65 xyoos).

Kev ua rau txoj kev kho tau tiav 2 lub lis piam tom qab pib kho, mus txog qhov siab kawg tom qab 4 lub lis piam thiab tawm tsam mus tas lub sijhawm kho.

Kev Tiv Thaiv Kab Mob Tiv Thaiv Kab Mob

Hauv txoj kev tshawb fawb Anglo-Scandinavian ntawm cov txiaj ntsig tshwm sim ntawm lub plawv, lipid-txo ceg (ASCOT-LLA), qhov cuam tshuam ntawm atorvastatin rau cov mob ntshav tuag thiab tsis mob ntshav siab rau lub plawv, nws tau pom tias cov nyhuv ntawm atorvastatin kho ntawm kev txhaj tshuaj ntawm 10 mg ntau dhau ntawm cov nyhuv ntawm cov placebo, thiab yog li ntawd tau txiav txim siab los txiav tawm lub sijhawm ua ntej. kev tshawb fawb tom qab 3.3 xyoos hloov qhov kwv yees 5 xyoo.

Atorvastatin txo txoj kev loj hlob ntawm cov teeb meem hauv qab no:

Tsis muaj qhov tseem ceeb txo qis hauv tag nrho thiab cov mob plawv tuag, txawm tias muaj cov ncauj lus zoo.

Hauv kev kawm txog kev cuam tshuam ntawm atorvastatin hauv cov neeg mob uas muaj ntshav qab zib hom 2 ntshav qab zib mellitus (CARDS) ntawm kev ua rau cov neeg tuag taus thiab tsis muaj txiaj ntsig ntawm cov kab mob plawv, nws tau pom tias kev kho mob nrog atorvastatin, tsis hais tus neeg mob poj niam, hnub nyoog, lossis theem pib ntawm LDL-C, txo qhov kev pheej hmoo ntawm kev tsim cov kev mob plawv hauv qab no. :

Hauv kev kawm txog kev thim rov qab ntawm kev txhim kho kev mob ntshav siab nrog kev mob ntshav siab nrog kev kho ntshav siab (REVERSAL) nrog atorvastatin ntawm kev txhaj tshuaj ntawm 80 mg rau cov neeg mob uas muaj mob plawv, nws tau pom tias qhov nruab nrab txo nyob rau hauv tag nrho cov ntim ntawm atheroma (thawj cov qauv ntawm kev ua tau zoo) txij li pib ntawm kev tshawb fawb yog 0.4%.

Cov Kev Pabcuam Cholesterol Tshaj Plaws (SPARCL) pom tias atorvastatin ntawm ib koob ntawm 80 mg rau ib hnub tau txo qhov kev pheej hmoo ntawm kev tuag taus lossis tsis tuag ntau hauv cov neeg mob uas muaj keeb kwm ntawm mob stroke lossis hloov ischemic nres tsis muaj ischemic mob plawv los ntawm 15%, piv nrog cov placebo. Tib lub sijhawm, txoj kev pheej hmoo ntawm kev mob plawv loj thiab cov txheej txheem rov ua haujlwm tau txo qis qis dua. Kev txo qis ntawm kev pheej hmoo ntawm cov hlab plawv thaum lub sij hawm kho nrog atorvastatin tau pom hauv txhua pawg tsuas yog ib qho uas suav nrog cov neeg mob thawj lossis rov qab mob hemorrhagic mob stroke (7 hauv pawg atorvastatin tiv thaiv 2 hauv cov pawg placebo).

Hauv cov neeg mob kho nrog atorvastatin kho ntawm ib koob ntawm 80 mg, qhov tshwm sim ntawm hemorrhagic lossis ischemic stroke (265 tiv thaiv 311) lossis IHD (123 tiv thaiv 204) tsawg dua nyob rau hauv pawg tswj hwm.

Thib ob tiv thaiv kev mob plawv

Hais txog Lub Hom Phiaj Tshawb Fawb Tshiab (TNT), qhov cuam tshuam ntawm atorvastatin ntawm koob tshuaj 80 mg rau ib hnub thiab 10 mg ib hnub ntawm kev pheej hmoo ntawm kev mob hlab plawv mob hauv cov neeg mob uas tau txais cov kab mob ntsig txog cov ntshav txhaws mob tau piv rau.

Atorvastatin ntawm koob tshuaj 80 mg txo qhov kev loj hlob ntawm cov teeb meem hauv qab no:

Cov tshuaj pleev raws li rosuvastatin - lwm cov tshuaj nquag

Atoris belongs rau cov pab pawg ntawm statins ntawm lub cim thib peb thiab tsis zoo li yav dhau los tiam dhau los, muaj qhov txo qis ntawm cov kev mob tshwm sim thiab lawv cov nyiaj feem ntau. Txawm li cas los xij, niaj hnub no cov neeg thib plaub twb muaj lawm, uas dhau los ua nrov dua thiab yav tom ntej, nws yog qhov ua tau los hloov kiag tus thib peb.

Cov tshuaj phiv yog rosuvastatin. Ua tsaug rau nws, txawm nrog kev siv tshuaj txhua hnub ntawm 5 mg, nws muaj peev xwm ua tiav qhov qub, thiab qee kis, tshwm sim sai dua. Pom tseeb, kev noj tshuaj qis dua muaj qhov ua tau zoo dua ntawm daim siab, ua rau muaj kev phiv tshwm sim tsawg dua, uas tshwj xeeb tshaj yog pom nrog kev kho mob ntev.

Txawm li cas los xij, ceev faj, vim hais tias txawm tias qhov tseeb hais tias ob tiam neeg ntawm cov tshuaj siv rau kev txo qis roj ntau lawm thiab tsim nyog rau cov neeg mob hypocholesterolemia, lawv cov ntsiab lus ntawm kev ua haujlwm ntawm lub cev yog qhov sib txawv me ntsis, uas cuam tshuam tsis tsuas yog lub txiaj ntsig ntawm kev kho mob, tab sis kuj lub xeev ntawm ntau lub cev.

Koj puas tseem xav tias kev tshem tawm cov ntshav siab yog tsis yooj yim sua?

Kev txiav txim los ntawm qhov tseeb tias koj tau nyeem cov kab no tam sim no - teeb meem ntawm cov roj cholesterol siab tuaj yeem ua rau koj xav tau ntev ntev. Tab sis cov no tsis yog tso dag txhua: cov kev hloov pauv tau cuam tshuam loj heev ntawm cov ntshav ncig thiab, yog tias tsis ua raws li, tuaj yeem ua rau qhov kev tu siab kawg nkaus.

Tab sis nws yog ib qho tseem ceeb kom nkag siab tias nws yog qhov tsim nyog los kho tsis yog qhov tshwm sim hauv daim ntawv ntawm lub siab lossis tsis nco, tab sis qhov ua rau. Tej zaum koj yuav tsum paub koj tus kheej nrog txhua cov cuab yeej ntawm kev ua lag luam, thiab tsis yog qhia tawm xwb? Qhov tseeb tiag, feem ntau, thaum siv tshuaj lom neeg npaj nrog kev phiv, cov txiaj ntsig tau txais uas yog nrov npe hu ua "ib qho kev kho mob, lwm tus ceg tawv". Hauv ib ntawm nws cov kev pabcuam, Elena Malysheva tau chwv txog cov ncauj lus siab thiab hais txog cov kev kho mob uas ua los ntawm cov khoom siv cog ib puag ncig ...

Cov Tshuaj Pharmacokinetics

Atorvastatin nrawm nrawm tom qab kev tswj hwm ntawm qhov ncauj, Cmax tau tiav tom qab 1-2 teev .Qhov ntawm qhov nqus thiab kev nqus ntawm atorvastatin hauv cov ntshav ntshav nce ntxiv hauv qhov sib piv rau cov koob tshuaj. Qhov tseeb ntawm bioavailability ntawm atorvastatin yog li ntawm 14%, thiab cov kab ke ua haujlwm ntawm lub cev muaj peev xwm tiv thaiv kev ua haujlwm tiv thaiv HMG-CoA reductase yog li 30%. Qes uas tsis muaj zog vim lub cev ua rau lub plab zom mov hauv lub plab thiab / lossis thaum "thawj hla" los ntawm lub siab. Khoom noj khoom haus txo tus nqi thiab ntau npaum li cas kev nqus los ntawm kwv yees li 25% thiab 9%, feem (raws li pom los ntawm cov txiaj ntsig ntawm kev txiav txim siab ntawm Cmax thiab AUC), tab sis qib ntawm LDL-C thaum noj atorvastatin ntawm ib plab khoob thiab thaum noj mov tsawg dua yuav luag sib luag. Txawm hais tias qhov tseeb hais tias tom qab noj atorvastatin nyob rau yav tsaus ntuj, nws cov ntshav plasma qis dua (Cmax thiab AUC kwv yees li 30%) dua li tom qab noj thaum sawv ntxov, qhov txo qis hauv LDL-C tsis yog nyob ntawm lub sijhawm ntawm hnub uas cov tshuaj noj.

Qhov nruab nrab Vd ntawm atorvastatin yog li 381 litres. Kev khi ntawm atorvastatin mus rau cov ntshav protein tsawg kawg yog 98%. Qhov piv ntawm atorvastatin qib hauv ntshav liab / ntshav ntshav yog kwv yees 0.25, i.e. atorvastatin tsis txeem cov ntshav liab kom zoo.

Atorvastatin ua rau cov khoom tsim ua tiav ortho- thiab para-hydroxylated derivatives thiab ntau yam beta-oxidation khoom. Hauv cov tshuaj vitro, ortho- thiab para-hydroxylated metabolites muaj qhov cuam tshuam rau HMG-CoA reductase, piv nrog ntawm atorvastatin. Cov kev tiv thaiv tsis ua haujlwm tiv thaiv HMG-CoA reductase yog kwv yees li 70% vim qhov kev ua ntawm cov roj ntsha hloov mus ua pa. Kev tshawb fawb hauv vitro qhia tias CYP3A4 isoenzyme ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv atorvastatin. Qhov no tau lees paub los ntawm kev nce ntxiv ntawm qhov kev nkag siab ntawm atorvastatin hauv tib neeg cov ntshav ntshav thaum noj erythromycin, uas yog qhov ua kom haum ntawm isoenzyme no.

Hauv cov kev tshawb fawb hauv vitro kuj tau qhia tias atorvastatin yog qhov ua kom tsis muaj zog ntawm CYP3A4 isoenzyme. Atorvastatin tsis tau muaj kev sib luag hauv kev kho mob hauv kev ua haujlwm ntawm lub siab ntawm terfenadine hauv ntshav, uas yog metabolized feem ntau los ntawm isoenzyme CYP3A4, hauv qhov no, qhov cuam tshuam loj ntawm atorvastatin rau lub pharmacokinetics ntawm lwm qhov chaw ntawm isoenzyme CYP3A4 yog qhov tsis zoo.

Atorvastatin thiab nws cov metabolites yog cov tawm nrog cov kua tsib tom qab cov kab mob hepatic thiab / lossis cov kab mob hnyav ntxiv (atorvastatin tsis tau nkag mus rau qhov loj dua ntawm kev nkag mus ua ke). T1 / 2 yog kwv yees li 14 teev, thaum lub zog inhibitory tshuaj cuam tshuam nrog HMG-CoA reductase yog kwv yees li 70% txiav txim los ntawm kev ua haujlwm ntawm cov roj ntsha hloov mus rau lub cev thiab lub nplhaib raug tshwj vim yog lawv muaj. Tom qab kev tswj hwm ntawm qhov ncauj, tsawg dua 2% ntawm koob tshuaj atorvastatin raug kuaj pom hauv cov zis.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Cov ntshav plasma concentration ntawm atorvastatin hauv cov neeg laus (hnub nyoog? 65 xyoo) yog siab dua (Cmax kwv yees li 40%, AUC los ntawm 30%) dua li ntawm cov neeg mob cov neeg laus uas muaj hnub nyoog yau. Tsis muaj kev sib txawv hauv kev nyab xeeb, kev ua tau zoo, lossis kev ua tiav ntawm lub hom phiaj ntawm kev kho lipid-txo qis hauv cov neeg laus piv rau cov pej xeem.

Cov kev tshawb fawb ntawm cov tshuaj pharmacokinetics ntawm cov tshuaj hauv cov menyuam yaus tsis tau ua.

Plasma ntau ntawm atorvastatin hauv cov poj niam sib txawv (Cmax kwv yees li 20% siab dua, thiab AUC 10% qis dua) los ntawm cov txiv neej.Txawm li cas los xij, thaj chaw kho mob tseem ceeb sib txawv hauv cov nyhuv ntawm cov tshuaj ntawm lipid metabolism hauv cov txiv neej thiab poj niam tsis tau txheeb xyuas.

Lub raum khiav tsis zoo tsis cuam tshuam qhov ncauj ntawm atorvastatin hauv ntshav ntshav lossis nws cov nyhuv ntawm lipid metabolism. Hauv qhov no, koob tshuaj hloov pauv ntawm cov neeg mob uas tsis muaj mob raum tsis ua haujlwm.

Atorvastatin tsis raug tshem tawm thaum lub caij hemodialysis vim yog txoj kev khaus rau cov ntshav muaj protein ntau.

Cov tshuaj Atorvastatin tau nce ntau (Cmax thiab AUC kwv yees li 16 thiab 11 zaug, feem ntau) hauv cov neeg mob uas muaj cawv cawv (cov chav kawm B ntawm Child-Pugh scale).

Kev qhia rau kev siv tshuaj LIPRIMAR®

• thawj hypercholesterolemia (heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia (hom IIa raws li kev faib tawm ntawm Fredrickson),
• tshuaj sib xyaw ua ke (sib xyaw) hyperlipidemia (hom IIa thiab IIb raws li kev faib tawm ntawm Fredrickson),
• dibetalipoproteinemia (hom III raws li kev faib tawm ntawm Fredrickson) (ntxiv rau ntawm kev noj haus),
• tsev neeg endogenous hypertriglyceridemia (hom IV raws li kev faib tawm ntawm Fredrickson), tiv taus kev noj haus,
• homozygous tsev neeg hypercholesterolemia nrog tsis muaj txiaj ntsig ntawm kev noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis yog ntawm kev siv tshuaj,
• kev tiv thaiv kab mob plawv hauv cov neeg mob uas tsis muaj kev kho mob ntawm cov mob plawv, tab sis nrog ntau yam kev pheej hmoo rau nws txoj kev loj hlob - lub hnub nyoog laus dua 55 xyoos, kev muaj nicotine, kev mob ntshav siab, ntshav qab zib mellitus, tsis tshua muaj ntau ntawm HDL-C hauv ntshav, kev mob caj ces, thiab lwm yam. cov sij hawm tawm tsam keeb kwm ntawm dyslipidemia,
• kev tiv thaiv kab mob thib ob hauv kev mob plawv hauv cov neeg mob plawv mob plawv txhawm rau txhawm rau txo qis kev phom sij tag nrho, mob ntshav hlab plawv, mob stroke, rov pw hauv tsev kho mob rau angina pectoris thiab qhov xav kom rov qab kho dua.

Tsuas tshuaj thiab tswj hwm

Ua ntej pib txoj kev kho mob nrog Liprimar, ib qho yuav tsum sim ua kom tiav tswj hwm hypercholesterolemia los ntawm kev noj haus, kev tawm dag zog thiab kev poob phaus hauv cov neeg mob rog, nrog rau kev kho mob ntawm lwm tus neeg.

Thaum muab tshuaj rau, cov neeg mob yuav tsum pom zoo rau kev noj zaub mov hypocholesterolemic noj, uas nws yuav tsum tau ua raws thaum lub sijhawm kho.

Cov tshuaj tau noj ntawm qhov ncauj thaum lub sijhawm thaum nruab hnub, tsis hais noj zaub mov. Cov koob tshuaj ntawm cov tshuaj txawv ntawm 10 mg txog 80 mg ib hnub ib zaug, xaiv cov koob tshuaj yuav tsum tau nqa tawm rau hauv tus account pib qib LDL-C, lub hom phiaj ntawm txoj kev kho thiab cov txiaj ntsig ib tus zuj zus. Qhov siab tshaj plaws yog 80 mg ib zaug ib hnub.

Thaum pib kho thiab / lossis thaum qhov nce ntxiv ntawm koob tshuaj Liprimar, nws yog qhov yuav tsum tau saib xyuas cov ntshav lipid cov ntsiab lus txhua 2-4 lub lis piam thiab kho qhov tshuaj raws li.

Rau thawj hom hypercholesterolemia thiab sib xyaw (sib xyaw) hyperlipidemia rau feem ntau cov neeg mob, koob tshuaj Liprimar yog 10 mg ib hnub ib zaug. Cov kev kho mob nyhuv ua rau pom nyob rau hauv 2 lub lis piam thiab feem ntau nce mus txog qhov siab tsis pub dhau 4 lub lis piam. Nrog kev kho mob ntev, cov nyhuv cuam tshuam.

Nrog homozygous tsev neeg hypercholesterolemia, cov tshuaj yog kws kho nyob rau hauv ib koob ntawm 80 mg ib hnub ib zaug. (txo qis hauv qib ntawm LDL-C los ntawm 18-45%).

Thaum lub siab tsis ua haujlwm, koob tshuaj Liprimar yuav tsum raug txo qis nyob rau hauv kev soj qab tas li ntawm ACT thiab ALT kev ua si.

Lub raum ua haujlwm tsis zoo cuam tshuam rau qhov kev txiav txim ntawm atorvastatin hauv ntshav ntshav lossis qhov siab ntawm qhov txo qis hauv cov ntsiab lus ntawm LDL-C thaum siv Liprimar, yog li ntawd, kev hloov tshuaj tsis tas yuav tsum tau txhaj.

Thaum siv cov tshuaj hauv cov neeg laus, tsis muaj qhov sib txawv ntawm kev nyab xeeb, kev ua tau zoo piv rau cov pej xeem sawv daws, thiab kev hloov tshuaj tsis tas yuav tsum tau.

Yog tias sib koom siv nrog cyclosporine yog qhov tsim nyog, koob tshuaj Liprimar® yuav tsum tsis pub tshaj 10 mg.

10 xyoo pheej hmoo = 160

* Qee cov kws tshaj lij pom zoo kom siv cov lipid-txo cov tshuaj uas txo cov ntsiab lus ntawm LDL-C yog tias qhov kev hloov pauv hauv txoj kev ua neej tsis ua rau nws cov ntsiab lus tsawg zuj zus mus rau theem ntawm cov lus qhia rau kev siv tshuaj

Muab qhov tseeb hais tias atherosclerosis yog ib qho kab mob tuag taus, nws tsim nyog mus ze rau kev kho mob nrog lub luag haujlwm. Tus qauv kub rau kev kho yog statins.

Tus txheej txheem ntawm lawv cov kev ua yog zoo ib yam rau tag nrho pawg thiab muaj qhov thaiv ntawm HMG-CoA reductase cov enzymes uas coj cov roj cholesterol hauv lub siab.

Nws tus nqi yog ib nrab ntawm qhov uas ua rau ntau tus neeg nyiam, vim tias cov nyiaj khaws cia yog 50%. Nws tau zoo tshaj tawm, muaj kev txheeb xyuas zoo txog nws, yog li neeg coj nws nrog kev txaus siab.

Cov tshuaj sib txawv heev nyob rau hauv muaj pes tsawg leeg, yog tias nyob rau hauv thawj daim ntawv qhia muaj tsuas yog thawj cov tshuaj atorvastatin thiab kev pabcuam hauv daim ntawv ntawm lactose, tom qab ntawd hauv Torvakard muaj ntau lub koomhaum pabcuam ntxiv.

Cov tshuaj muaj pes tsawg leeg suav nrog:

1. Atorvastatin calcium ntsev, 10 milligrams - cov tshuaj nquag,
2. Croscarmellose sodium - ib qho tsis sib haum xeeb uas muab cov tshuaj qhuav hauv plab tshem tawm,
3. Magnesium oxide tiv thaiv clumping,
4. Lactose monohydrate - muab tub lim rau kis tau los ntawm qhov ntau txaus,
5. Monocrystalline kua nplaum yog qhov tsw thiab qhov tsw tsw,
6. Magnesium stearate yog cov khoom coj los tiv thaiv cov khoom ua kom yooj yim rau kev tsim khoom thiab ntim.

Muaj pes tsawg leeg lub plhaub taum muaj xws li:

• titanium dioxide - cov ntxhia ntxhia hauv cov roj nplua,
• talc yog cov tshuaj txav tawm uas txo qhov ntxhib vim kev adsorption nyob rau saum npoo ntawm granules.

Raws li tuaj yeem pom los ntawm cov keeb kwm yav dhau los, cov tshuaj Torvakard muaj ntau yam phom sij uas ua rau hnyav nce thiab nws cov khoom siv lub cev. Rau ntau yam ntawm cov khoom no, kev tsis haum tshuaj tiv thaiv kab mob tuaj yeem tsim kev tsis haum lossis kev tawm tsam ntawm kev tsis haum, suav txij li khaus ntawm daim tawv nqaij mus rau Quincke's edema, yog li lawv tsis pom zoo kom siv cov tshuaj. Lossis, ntsuas uantej nrog kev sim tshuaj allergenic rau cov khoom sib txuas no kom ntseeg tau tias kev noj tshuaj kom zoo rau kev nyab xeeb.