Fraxiparin daws analogue

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb FraxiparinCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Fraxiparin hauv lawv cov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov tshuaj ntawm Fraxiparin nyob rau ntawm qhov muaj cov qauv qauv. Siv rau kev kho mob thiab tiv thaiv kom tsis txhob mob thrombosis thiab thromboembolism hauv cov laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation.

Fraxiparin - yog lub cev nyhav molecular heparin (NMH) tau los ntawm depolymerization los ntawm tus qauv heparin, yog glycosaminoglycan nrog qhov nruab nrab molecular hnyav ntawm 4300 daltons.

Nws ua rau pom lub peev xwm loj los khi rau cov ntshav plasma protein nrog antithrombin 3 (AT 3). Qhov kev khi no ua rau muaj kev cuam tshuam sai ntawm qhov muaj txiaj ntsig 10a, uas ua rau muaj qhov ua tau zoo siab ntawm nadroparin (cov tshuaj nquag ntawm yeeb tshuaj Fraxiparin).

Lwm yam kev ua haujlwm muab cov txiaj ntsig antithrombotic ntawm nadroparin muaj xws li kev ua haujlwm ntawm lub cev nqaij daim tawv hloov dua siab tshiab (TFPI), kev ua haujlwm ntawm fibrinolysis los ntawm kev tawm ncaj qha ntawm cov nqaij mos plasminogen activator los ntawm endothelial hlwb, thiab kev hloov kho ntawm cov ntshav rheological (txo cov ntshav viscosity thiab nce permeability ntawm platelet thiab granulocyte membranes).

Calcium nadroparin yog cov yam ntxwv ntawm siab dua-10a kev sib piv piv rau anti-2a factor lossis antithrombotic kev ua haujlwm thiab muaj ob qho kev ua tam sim thiab ntev antithrombotic.

Muab piv rau cov tshuaj heparin tsis sib haum xeeb, nadroparin muaj cov nyhuv qis dua ntawm cov platelet muaj nuj nqi thiab kev sib sau ua ke, thiab cov lus hais tsawg dua rau ntawm kev kho mob hemostasis.

Hauv kev tiv thaiv koob tshuaj, Fraxiparin tsis ua rau muaj qhov txo qis hauv APTT.

Nrog rau kev kho mob lub sijhawm lub sijhawm ua haujlwm siab tshaj plaws, kev nce qib hauv APTT rau tus nqi 1.4 lub sijhawm siab dua li tus qauv yog ua tau. Xws li lub caij nyoog ntev ua kom pom qhov muaj qhov ua tau antithrombotic ntawm calcium nadroparin.

Muaj pes tsawg leeg

Calcium nadroparin + excipients.

Cov Tshuaj Pharmacokinetics

Pharmacokinetic cov yam ntxwv tau txiav txim siab los ntawm kev hloov pauv ntawm 10-qhov cuam tshuam kev ua haujlwm ntawm ntshav.

Fraxiparin yuav nqus tau yuav luag txhua yam (kwv yees 88%). Nrog kev tswj hwm kev cia siab, qhov siab tshaj plaws los tiv thaiv 10a cov haujlwm yog ua tiav hauv tsawg dua 10 feeb. Nws yog metabolized feem ntau hauv lub siab los ntawm desulfation thiab depolymerization.

Cov txiaj ntsig ntawm txoj kev tshawb no pom tias nadroparin muaj kev tso me ntsis kom pom rau cov neeg mob uas tsis tshua mob hlwb lossis mob raum (CC ≥ 30 ml / min thiab

Cov lus qhia rau kev siv thiab ntau npaum li cas

Yuav ua li cas thiab nyob qhov twg los txhaj tshuaj Fraxiparin - txheej txheem kev txhaj tshuaj

Thaum muab tshuaj subcutaneously, cov tshuaj zoo dua yog siv rau hauv tus neeg mob lub chaw supine, hauv cov nqaij mos ntawm qhov chaw anterolateral lossis posterolateral ntawm lub plab mog, hloov ntawm sab xis thiab sab laug. Tso cai nkag mus rau hauv tus ncej puab.

Txhawm rau kom tsis txhob ploj ntawm cov tshuaj thaum siv cov koob txhaj tshuaj, cov pa npuas yuav tsum tsis txhob muab tshem tawm ua ntej kev txhaj tshuaj.

Cov koob yuav tsum tau muab tso rau hauv txiav, thiab tsis nyob ntawm kaum sab xis, rau hauv txheej pinched ntawm daim tawv nqaij tsim los ntawm tus ntiv tes xoo thiab forefinger. Cov quav yuav tsum tswj xyuas thaum lub sijhawm tag nrho ntawm kev tswj hwm ntawm cov tshuaj. Tsis txhob txhuam thaj tsam tom qab txhaj tshuaj.

Txog kev tiv thaiv ntawm thromboembolism hauv kev kho mob dav dav, kev pom zoo koob tshuaj Fraxiparin yog 0.3 ml (2850 anti-10a ME) s / c. Cov tshuaj raug muab tshuaj 2-4 teev ua ntej phais, tom qab ntawd - 1 zaug ib hnub. Kev kho yog txuas mus tsawg kawg 7 hnub lossis sijhawm tag nrho lub sijhawm muaj kev pheej hmoo mob thrombosis, kom txog rau thaum tus neeg mob hloov mus rau qhov chaw kho mob.

Txhawm rau tiv thaiv thromboembolism thaum ua haujlwm orthopedic, Fraxiparin raug tswj hwm subcutaneously ntawm koob tshuaj txiav txim siab nyob ntawm tus neeg mob lub cev qhov hnyav ntawm tus nqi ntawm 38 anti-10a IU / kg, uas tuaj yeem raug nce rau 50% nyob rau hnub 4 tom qab ua haujlwm. Thawj qhov tshuaj tau yog 12 teev ua ntej kev phais mob, qhov tshuaj thib ob - 12 teev tom qab ua haujlwm tiav. Ntxiv mus, Fraxiparin tseem txuas ntxiv siv ib hnub ib zaug thaum lub sijhawm tag nrho lub sijhawm muaj kev pheej hmoo ntawm thrombosis txog thaum tus neeg mob pauv mus rau ib qho chaw sab nrauv. Kev kho mob tsawg kawg nkaus yog 10 hnub.

Hauv kev kho mob ntawm kev puas siab puas ntsws angina pectoris thiab myocardial infarction tsis muaj Q yoj, Fraxiparin raug xaj sc 2 zaug hauv ib hnub (txhua 12 teev). Lub sijhawm kho yog feem ntau 6 hnub. Hauv cov kev tshawb fawb soj ntsuam, cov neeg mob uas tsis khov kho angina pectoris / myocardial infarction tsis muaj Q yoj Fraxiparin raug suav nrog kev sib xyaw nrog acetylsalicylic acid ntawm ib koob ntawm 325 mg ib hnub twg.

Qhov muab tshuaj thawj zaug yog muab ib qho tshuaj txhaj ib leeg muaj ntshav, tom qab ntawv txhaj tshuaj yog noj tshuaj subcutaneously. Qhov koob tshuaj tau teeb tsa nyob ntawm lub cev qhov hnyav ntawm tus nqi ntawm 86 anti-10a IU / kg.

Hauv kev kho mob ntawm thromboembolism, tshuaj tiv thaiv kab mob hauv lub qhov ncauj (thaum tsis muaj contraindications) yuav tsum tau kho kom sai li sai tau. Kev kho nrog Fraxiparin tsis nres mus txog rau thaum cov phiaj xwm qhov tseem ceeb ntawm prothrombin lub sij hawm ntsuas tau mus txog. Cov tshuaj tau sau s / c 2 zaug hauv ib hnub (txhua 12 teev), lub sijhawm ib txwm muaj rau 10 hnub. Cov koob tshuaj yog nyob ntawm tus neeg mob lub cev qhov hnyav raws li 86 anti-10a IU / kg lub cev qhov hnyav.

Sab sij huam

• los ntshav ntawm ntau lub zos,
• thrombocytopenia
• eosinophilia, thim rov qab tom qab tsum tsis siv tshuaj,
• kev tiv thaiv tsis haum lub cev (Quincke's edema, tawv nqaij cuam tshuam),
• qhov tsim ntawm ib qho me subcutaneous hematoma ntawm qhov chaw txhaj tshuaj,
• daim tawv necrosis, feem ntau nyob ntawm thaj chaw txhaj tshuaj,
• priapism
• thim rov qab hyperkalemia (cuam tshuam nrog kev muaj peev xwm ntawm heparins los tiv thaiv aldosterone secretion, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev pheej hmoo).

Cov Yuav Tsum Tau Ua

• thrombocytopenia nrog keeb kwm ntawm nadroparin,
• cov cim qhia txog los ntshav los yog muaj feem yuav los ntshav nrog cuam tshuam nrog hemostasis (tsis suav DIC, tsis yog mob los ntawm heparin),
• organic kev puas tsuaj nrog kev nyiam rau los ntshav (piv txwv li, mob plab hnyuv lossis mob duodenal),
• kev raug mob lossis phais kev cuam tshuam rau ntawm lub hlwb thiab tus txha caj qaum lossis hauv qhov muag,
• txoj hlab ntshav mob intracranial,
• mob hlab ntsha hlwb endocarditis,
• mob raum tsis ua haujlwm (CC

Cov tshuaj ntawm cov tshuaj Fraxiparin

Cov analogue yog kim dua los ntawm 2164 rubles.

Wessel Douay F yog tus cwj pwm ncaj qha yeeb yam (anticoagulant) raws li sulodexide hauv tshuaj ntau npaum li cas 250 LE. Nws tuaj yeem raug kho rau kev kho mob ntawm cerebrovascular kev huam yuaj, mob vascular, dementia vein thrombosis thiab lwm yam kab mob.

Cov analogue kim dua los ntawm 527 rubles.

Chaw tsim tshuaj paus: Sanofi Winthrop Kev Lag Luam (Fabkis)
Cov Ntawv Tso Tawm:

• Koob txhaj 10 txhiab .Cov tshuaj tiv thaiv CHAME / ml 0.6 ml, 2 pcs., Nqe los ntawm 826 rubles

Clexane yog tus Fabkis cov yeeb yam ncaj qha-ua yeeb yam. Muaj nyob rau hauv daim ntawv ntawm cov tshuaj muaj enoxaparin sodium. Nws yog ntawv kho raws li prophylactic rau kev mob hlab ntsha, thiab ntxiv rau kev kho mob ntawm cov leeg ntshav ntawm lub qhov txhab. Thaum cev xeeb tub thiab lactation tuaj yeem tsim kho tsuas yog tshwj xeeb.

Cov analogue yog kim dua los ntawm 1428 rubles.

Anfibra yog ib nyuag kim dua cov khoom noj ntawm cov khoom lag luam hauv tsev. Muag hauv ib pob ntawm 10 ampoules, txhua ntawm cov muaj enoxaparin sodium. Vim tias muaj qhov sib txawv ntawm cov muaj pes tsawg leeg, nws tuaj yeem ua qhov hloov pauv hloov tau tsuas yog tom qab tau xaiv tus kws kho mob.

Cov analogue yog kim dua los ntawm 1868 rubles.

Angioflux yog yeeb tshuaj Lavxias los ntawm tib lub chaw muag tshuaj. Nws txawv ntawm Fragmin nyob rau hauv muaj pes tsawg leeg, tab sis muaj thaj tsam zoo sib xws. Nws tuaj yeem siv tshuaj rau kev mob angiopathy, muaj kev pheej hmoo ntawm thrombosis, thawj theem ntawm sab ceg qis ischemia. Muaj ntau qhov sib txawv ntawm cov lus contraindications thiab muaj cov kev mob tshwm sim.

Cov analogue kim dua los ntawm 1256 rubles.

Chaw tsim tshuaj paus: Vetter Pharma-Fertigung GmbH (Lub Tebchaws Yelemees)
Cov Ntawv Tso Tawm:

• Syringe 2500 IU, 0.2 ml, 10 pcs., Nqe los ntawm 1555 rubles

Fragmin yog tshuaj German tsim cov tshuaj nyob rau hauv kev daws teeb meem rau kev tswj kav dej thiab ntu. Nws tuaj yeem raug kho rau kev kho mob ntawm txoj kev mob siab ntsws thiab mob ntsws txhaws, tsis muaj ntshav tsis khov thiab myocardial infarction (tsis muaj Q yoj ntawm ECG), ntxiv rau kev tiv thaiv ntawm thrombosis thaum kev phais mob.

Cov analogue yog kim dua los ntawm 1418 rubles.

Enixum yog hloov pauv rau Wessel Douay F anticoagulant kev ua, uas muaj cov xwm txheej zoo sib xws. Cov sib txawv ntawm cov thawj hauv cov nquag ua kom muaj - enoxaparin sodium. Cov tshuaj yog muab tshuaj subcutaneously lossis txhaj tshuaj rau. Txoj kev nyab xeeb thiab kev siv tshuaj ntawm cov tshuaj rau cov menyuam yaus hnub nyoog qis dua 18 xyoo tsis tau kawm.

Cov analogue yog pheej yig dua los ntawm 134 rubles.

Chaw tsim tshuaj paus: Italfarmako S.p.A. (Ltalis)
Cov Ntawv Tso Tawm:

• Cov koob txhaj 10 txhiab anti-Ha ME / ml 0.2 ml, 1 pc., Nqe los ntawm 165 rubles

Ib tug pheej yig dua-ua Italian khoom. Nws yog muag hauv hom kev daws teeb meem rau kev tswj hwm subcutaneous thiab enoxaparin sodium hauv tshuaj txij li 2000 txog 6000 IU yog siv ntawm no los ua cov tshuaj yeeb dej caw. Raws li cov cim tseem ceeb rau kev teem caij sib ntsib, nws zoo ib yam li Clexane thiab tseem raug tshaj tawm rau cov mob thrombosis (kev kho mob thiab kev tiv thaiv).

Kev ntsuas rau siv

Dab tsi pab Fraxiparin? Raws li cov lus qhia, cov tshuaj yog tshuaj hauv cov kis hauv qab no:

• kev tiv thaiv ntawm cov teeb meem thromboembolic thaum kev tiv thaiv dav dav lossis orthopedic phais kev,
• nyob rau hauv cov neeg mob uas muaj kev pheej hmoo loj ntawm cov teeb meem thromboembolic (ua pa tsis ua haujlwm thiab / lossis kab mob sib kis ntawm txoj hlab ua pa, thiab / lossis lub plawv tsis zoo) mus pw hauv tsev kho mob tshwj xeeb, kev kho mob ntawm thromboembolic muaj teeb meem,
• kev tiv thaiv ntawm cov ntshav coagulation thaum hemodialysis, kev kho mob ntawm tsis khov tsis khov thiab myocardial infarction yam tsis muaj qhov tsis txaus Q yoj ntawm ECG.

Cov lus qhia rau kev siv Fraxiparin, ntau npaum

Thaum muab tshuaj subcutaneously, cov tshuaj zoo dua yog siv rau hauv tus neeg mob lub chaw supine, hauv cov nqaij mos ntawm qhov chaw anterolateral lossis posterolateral ntawm lub plab mog, hloov ntawm sab xis thiab sab laug. Tso cai nkag mus rau hauv tus ncej puab.

Txhawm rau kom tsis txhob ploj ntawm cov tshuaj thaum siv cov koob txhaj tshuaj, cov pa npuas yuav tsum tsis txhob muab tshem tawm ua ntej kev txhaj tshuaj.

Cov koob yuav tsum tau muab tso rau hauv txiav, thiab tsis nyob ntawm kaum sab xis, rau hauv txheej pinched ntawm daim tawv nqaij tsim los ntawm tus ntiv tes xoo thiab forefinger. Cov quav yuav tsum tswj xyuas thaum lub sijhawm tag nrho ntawm kev tswj hwm ntawm cov tshuaj. Tsis txhob txhuam thaj tsam tom qab txhaj tshuaj.

• Txog kev tiv thaiv ntawm thromboembolism hauv kev kho mob dav dav, kev pom zoo koob tshuaj Fraxiparin yog 0.3 ml (2850 anti-Xa ME) s / c. Cov tshuaj raug muab tshuaj 2-4 teev ua ntej phais, tom qab ntawd - 1 zaug ib hnub. Kev kho yog txuas mus tsawg kawg 7 hnub lossis sijhawm tag nrho lub sijhawm muaj kev pheej hmoo mob thrombosis, kom txog rau thaum tus neeg mob hloov mus rau qhov chaw kho mob.
• Txhawm rau tiv thaiv thromboembolism thaum ua haujlwm orthopedic, Fraxiparin raug tswj hwm subcutaneously ntawm koob tshuaj raws li tus neeg mob lub cev hnyav ntawm tus nqi ntawm 38 anti-XA IU / kg, uas tuaj yeem raug nce mus rau 50% nyob rau 4 hnub tom qab hnub tas. Thawj qhov tshuaj tau yog 12 teev ua ntej kev phais mob, qhov tshuaj thib ob - 12 teev tom qab ua haujlwm tiav. Ntxiv mus, Fraxiparin tseem txuas ntxiv siv ib hnub ib zaug thaum lub sijhawm tag nrho lub sijhawm muaj kev pheej hmoo ntawm thrombosis txog thaum tus neeg mob pauv mus rau ib qho chaw sab nrauv. Kev kho mob tsawg kawg nkaus yog 10 hnub.
• Cov neeg mob uas muaj kev pheej hmoo siab mob thrombosis (feem ntau yog nyob hauv chav tu neeg mob / chav saib xyuas mob hnyav / ua tsis taus pa thiab / lossis mob ntsws thiab / lossis plawv nres /) tus neeg mob. Thov kev pab thaum lub sijhawm tag nrho ntawm kev pheej hmoo ntawm thrombosis.
• Hauv kev kho mob ntawm kev puas siab puas ntsws angina pectoris thiab myocardial infarction tsis muaj Q nthwv dej, s / c raug xaj 2 zaug hauv ib hnub (txhua 12 teev). Lub sijhawm kho yog feem ntau 6 hnub. Hauv cov kev tshawb fawb soj ntsuam, cov neeg mob uas tsis khov kho angina pectoris / myocardial infarction tsis muaj Q yoj Fraxiparin raug suav nrog kev sib xyaw nrog acetylsalicylic acid ntawm ib koob ntawm 325 mg / hnub. Cov lus qhia rau kev siv pom zoo tias qhov pib muab tshuaj yog muab ib koob txhaj ib koob tshuaj, ib koob tshuaj tom ntej tau muab s.c. Qhov koob tshuaj tau teem nyob ntawm lub cev qhov hnyav ntawm tus nqi ntawm 86 anti-XA IU / kg.
• Hauv kev kho mob ntawm thromboembolism, tshuaj tiv thaiv kab mob hauv lub qhov ncauj (thaum tsis muaj contraindications) yuav tsum tau kho kom sai li sai tau. Txoj kev kho tsis nres mus txog thaum phiaj cov txiaj ntsig prothrombin lub sij hawm ntsuas tau mus txog. Cov tshuaj tau sau s / c 2 zaug hauv ib hnub (txhua 12 teev), lub sijhawm ib txwm muaj rau 10 hnub. Qhov koob tshuaj yog nyob ntawm tus neeg mob lub cev qhov hnyav ntawm qhov nqi ntawm 86 anti-XA ME / kg lub cev hnyav.

Cov lus qhia tshwj xeeb

Tsis txhob txhaj cov tshuaj intramuscularly!

Hauv cov neeg mob uas muaj kev pheej hmoo los ntshav, koj tuaj yeem siv ib nrab ntawm cov tshuaj uas pom zoo ntawm cov tshuaj.

Yog tias lub lim piam lim ntshav ntev dua li 4 teev, ntxiv cov koob tshuaj me me ntxiv yuav raug tswj hwm.

Hauv cov neeg laus cov neeg mob, tsis tas yuav txhaj tshuaj kho (tshwj tsis yog cov neeg mob uas lub raum lub raum tsis ua haujlwm). Ua ntej pib kho nrog Fraxiparin, nws raug nquahu kom soj ntsuam cov cim ua haujlwm raum.

Hauv cov neeg mob uas mob me mus rau mob raum tsis ua haujlwm (CC ≥ 30 ml / min thiab

3 kev xyuas rau “Fraxiparin”

Tom qab phais mob lawv tau pib ua rau kuv, nyob rau hnub thib ob muaj qhov tsis haum txaus pib ntawm qhov chaw txhaj tshuaj, Kuv yuav tsum tso nws - tab sis nws tsis mob

Txav los ntawm nws mus rau Kleksan, nws yooj yim dua rau pob. Kuv tsis tuaj yeem hais qhov tshwm sim, vim tias kuv dhau qhov kev ntsuam xyuas tom qab hloov mus rau clexane ... tab sis txhua yam zoo!

Kuv nug tus kws kho mob clexane lossis fraksiparin zoo dua prick. Tus kws kho mob tau hais tias twv yuav raug hu ua fraksiparin. Tsawg kawg txawm tias kev xyaum siv cov tshuaj no hauv cov poj niam cev xeeb tub yog qhov dav dua thiab kawm ntau dua.