Cov txheej txheem ntawm kev ua ntawm insulin "Detemir", lub npe lag luam, thaum tsim kho, nws muaj pes tsawg leeg, analogues, nqi, tus neeg mob tshuaj xyuas txog kev kho mob nrog tshuaj, tus nqi

Cov tshuaj insulin npaj muaj ntau yam sib txawv. Qhov no yog vim qhov xav tau los siv tshuaj uas tsim nyog rau cov neeg uas muaj tus yam ntxwv sib txawv.

Yog tias koj tsis kam txais ntawm cov tshuaj ntawm ib hom tshuaj, koj yuav tsum siv lwm yam, uas yog vim li cas cov kws tshuaj yuav txhim kho cov tshuaj tshiab thiab cov tshuaj uas tuaj yeem siv los kho cov tsos mob ntshav qab zib. Ib ntawm lawv yog Detemir insulin.

Cov ntaub ntawv dav dav thiab thaj chaw muag tshuaj

Cov tshuaj no zwm rau cov chav kawm ntawm insulin. Nws muaj cov yam ntxwv ntev. Lub npe lag luam ntawm cov tshuaj yog Levemir, txawm hais tias muaj ib cov tshuaj hu ua Insulin Detemir.

Daim foos uas tus neeg sawv cev faib no yog qhov kev daws teebmeem rau kev tswj hwm. Nws lub hauv paus yog cov khoom siv tau los siv cov thev naus laus zis DNA technology - Detemir.

Cov tshuaj no yog ib qho ntawm soluble analogues ntawm tib neeg cov tshuaj insulin. Lub hauv paus ntsiab lus ntawm nws cov kev ua yog txo cov piam thaj hauv lub cev ntawm cov ntshav qab zib.

Siv cov tshuaj tsuas yog raws li cov lus qhia. Cov koob tshuaj thiab kev txhaj tshuaj yog xaiv los ntawm kws kho mob. Kev hloov pauv tus kheej ntawm koob tshuaj lossis tsis ua raws li cov lus qhia tuaj yeem ua rau dhau ib qho kev noj haus, uas ua rau lub cev tsis tuaj yeem. Tsis tas li, koj yuav tsum tsis txhob tso tseg cov tshuaj yam tsis muaj kev paub txog ntawm tus kws kho mob, vim tias qhov no yog qhov txaus ntshai nrog kev cuam tshuam ntawm tus kab mob.

Cov tshuaj nquag siv ntawm cov tshuaj yog ib qho tshuaj ntawm tib neeg cov tshuaj insulin. Nws qhov kev txiav txim yog txawv hauv lub sijhawm. Lub cuab yeej nkag mus rau hauv kev sib cuag nrog cov txais ntawm cov xoos ntawm tes, kom nws txoj kev nqus sai dua.

Kev cai ntawm cov piam thaj ntau ntau nrog nws cov kev pab yog ua tiav los ntawm nce tus nqi ntawm nws noj los ntawm cov leeg nqaij. Cov tshuaj no tseem thaiv qhov ua cov piam thaj nyob hauv daim siab. Raws li nws cov cawv, cov haujlwm ntawm lipolysis thiab proteolysis txo qis, thaum ntau cov protein ntxiv nquag tshwm sim.

Qhov loj tshaj plaws ntawm Detemir hauv cov ntshav yog 6-8 teev tom qab txhaj tshuaj tas. Qhov kev lees paub ntawm cov khoom no tshwm sim yuav luag txhua tus neeg mob (nrog kev hloov pauv me me), nws muab faib rau qhov nyiaj ntawm 0.1 l / kg.

Thaum nws nkag rau hauv kev sib txuas nrog cov plasma protein, cov roj ntsha tsis ua haujlwm yog tsim. Kev tshem tawm yog nyob ntawm ntau npaum li cas cov tshuaj tau muab rau tus neeg mob thiab sai npaum li cas nqus tau tshwm sim. Ib nrab ntawm cov tshuaj yog muab tshem tawm los ntawm lub cev tom qab 5-7 teev.

Kev taw qhia, txoj hauv kev ntawm kev tswj hwm, koob tshuaj

Hais txog kev npaj tshuaj insulin, cov lus qhia rau kev siv yuav tsum ua kom pom meej. Nws yuav tsum ua tib zoo kawm, tab sis nws yog qhov tseem ceeb ib yam nkaus rau hauv koj tus account cov lus pom zoo ntawm kws kho mob.

Qhov ua tau zoo ntawm kev kho nrog cov tshuaj yog nyob ntawm seb yuav ua li cas kho daim duab ntawm tus kab mob tau raug tshuaj xyuas. Hauv kev sib txuas nrog nws, kev sib zog ntawm cov tshuaj thiab cov sijhawm ua haujlwm ntawm kev txhaj tshuaj yog txiav txim siab.

Kev siv cov cuab yeej no yog qhia rau kev kuaj mob ntshav qab zib. Tus kab mob tuaj yeem ua rau ob hom thawj thiab hom thib ob. Qhov txawv yog tias mob ntshav qab zib ntawm thawj hom, Detemir feem ntau yog siv los kho mob hlwb, thiab hauv hom ob, cov tshuaj no ua ke nrog lwm txoj kev. Tab sis kuj yuav muaj kev zam vim yog qee tus yam ntxwv.

Qhov ntau npaum li cas tau txiav txim siab los ntawm tus kws kho mob koom nrog, coj mus rau hauv tus account peculiarities ntawm chav kawm ntawm tus kab mob, tus neeg mob txoj kev ua neej, cov ntsiab cai ntawm nws kev noj haus thiab qib ntawm kev ua si. Kev hloov pauv ntawm ib qho ntawm cov xwm txheej no yuav tsum tau hloov kho rau lub sijhawm thiab qhov tsuas tau.

Kev txhaj tshuaj tuaj yeem ua tau txhua lub sijhawm, thaum nws yooj yim rau tus neeg mob. Tab sis nws yog ib qho tseem ceeb tias kev txhaj tshuaj ntxiv yog kwv yees li tib lub sijhawm uas tau ua tiav thawj zaug. Nws raug tso cai nkag mus rau hauv cov khoom hauv tus ncej puab, lub xub pwg, lub xub pwg plab phab ntsa, pob tw. Nws tsis raug tso cai los muab kev txhaj tshuaj rau tib thaj chaw - qhov no tuaj yeem ua rau lipodystrophy. Yog li ntawd, nws yuav tsum txav mus nyob hauv thaj chaw raug cai.

Daim video qhia txog cov txheej txheem ntawm kev muab cov tshuaj insulin siv cov koob txhaj tshuaj siv:

Cov sib txuam thiab cov kev txwv

Koj yuav tsum paub nyob rau hauv cov xwm txheej twg ntawm kev siv cov tshuaj no yog contraindicated. Yog tias tsis coj mus rau hauv tus account, tus neeg mob yuav cuam tshuam loj heev.

Raws li cov lus qhia, insulin muaj ob peb contraindications.

Cov no suav nrog:

1. Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj. Vim tias nws, cov neeg mob tau ua xua rau cov tshuaj no. Qee qhov kev cuam tshuam no ua rau muaj kev hem thawj rau lub neej.
2. Cov menyuam hnub nyoog (qis dua 6 xyoo). Txheeb xyuas qhov ua tau zoo ntawm cov tshuaj rau cov menyuam yaus hauv lub hnub nyoog no tsis ua haujlwm. Tsis tas li ntawd, tsis muaj ntaub ntawv qhia txog kev nyab xeeb ntawm kev siv hauv lub hnub nyoog no.

Muaj qee lub sijhawm hauv kev siv cov tshuaj no tso cai, tab sis xav tau kev tswj tshwj xeeb.

Ntawm lawv yog:

1. Mob siab. Yog tias lawv nyob ntawd, qhov kev txiav txim ntawm cov nquag tivthaiv yuav tuaj yeem cuam tshuam, yog li, cov tshuaj yuav tsum tau kho.
2. Ua txhaum ntawm ob lub raum. Hauv qhov no, hloov cov hauv paus ntsiab lus ntawm kev ua ntawm cov yeeb tshuaj kuj tseem muaj peev xwm - nws tuaj yeem nce lossis tsawg. Kev tswj kom ruaj khov kho cov txheej txheem kho yuav pab daws qhov teeb meem.
3. Laus lub caij nyoog. Lub cev ntawm cov neeg muaj hnub nyoog ntawm 65 xyoo tab tom muaj kev hloov pauv ntau. Ntxiv rau mob ntshav qab zib, cov neeg mob no muaj lwm yam kab mob, suav nrog mob siab thiab mob raum. Tab sis txawm tias lawv tsis muaj, cov kabmob no tsis ua haujlwm zoo li hauv cov hluas. Yog li, rau cov neeg mob no, kev siv tshuaj kom yog yog ib qho tseem ceeb.

Thaum tag nrho cov nta no raug suav, qhov kev pheej hmoo ntawm qhov tsis zoo los ntawm kev siv Detemir insulin tuaj yeem raug txo kom tsawg.

Raws li cov kev tshawb fawb cuam tshuam txog cov ncauj lus no, cov tshuaj tsis muaj qhov tsis zoo nyob rau hauv chav kawm ntawm cev xeeb tub thiab kev txhim kho ntawm lub cev. Tab sis qhov no tsis ua rau nws muaj kev nyab xeeb kiag li, yog li cov kws kho mob txhawm rau qhov kev pheej hmoo ua ntej teem nws niam yav tom ntej.

Thaum siv cov tshuaj no, koj yuav tsum ua tib zoo saib xyuas chav kawm ntawm txoj kev kho mob, kuaj xyuas qib qab zib. Thaum lub sijhawm hloov cev tes taw, cov ntsuas cov kua nplaum tuaj yeem hloov pauv, yog li, tswj hwm lawv thiab kho cov sijhawm ntawm cov tshuaj insulin yog qhov tsim nyog.

Tsis muaj lus qhia meej txog kev nkag mus ntawm cov khoom nquag mus rau niam mis. Tab sis nws ntseeg tau hais tias txawm tias nws tau txais rau tus menyuam, qhov tsis zoo yuav tsum tsis txhob tshwm sim.

Detemir insulin yog ntawm keeb kwm protein, yog li nws yooj yim nqus tau. Qhov no qhia tau hais tias kev kho leej niam nrog cov tshuaj no yuav tsis ua mob rau tus menyuam. Txawm li cas los xij, cov poj niam nyob rau lub sijhawm no yuav tsum tau ua raws kev noj haus, nrog rau tshuaj xyuas qhov concentration ntawm cov piam thaj.

Phiv thiab haus tshaj

Ib qho tshuaj twg, suav nrog insulin, tuaj yeem tsim kev phiv. Qee zaum lawv tshwm sim rau lub sijhawm luv luv, kom txog thaum lub cev tau yoog raws li kev ua ntawm cov khoom nquag.

Hauv lwm qhov xwm txheej, cov kab mob pathological tshwm sim los ntawm kev kuaj mob tsis pom tseeb lossis ntau dhau ntawm cov koob tshuaj. Qhov no ua rau muaj kev mob nyhav heev, uas qee zaum tuaj yeem ua rau tus neeg mob txoj kev tuag. Yog li, txhua qhov kev cuam tshuam nrog cov tshuaj no yuav tsum ceeb toom rau tus kws kho mob uas koom nrog.

Ntawm cov kev phiv tshuaj suav nrog:

1. Kev ntshav siab. Qhov xwm txheej no cuam tshuam nrog kev txo cov ntshav qab zib kom tsawg, uas tseem cuam tshuam rau kev noj qab haus huv ntawm cov ntshav qab zib. Cov neeg mob muaj kev cuam tshuam xws li mob taub hau, tshee tshee, xeev siab, tachycardia, tsis nco qab, thiab lwm yam. Hauv cov ntshav qog ntshav hnyav, tus neeg mob xav tau kev pab maj nrawm, txij li thaum nws qhov tsis muaj kev hloov pauv hauv cov qauv ntawm lub paj hlwb tuaj yeem tshwm sim.
2. Pom kev tsis pom kevCov. Qhov tshwj xeeb tshaj plaws yog cov ntshav qab zib retinopathy.
3. Kev ua xuaCov. Nws tuaj yeem tshwm sim nws tus kheej xws li kev tsis haum tshuaj (xoo pob liab liab, tawv nqaij), thiab nrog cov tsos mob nquag (mob anaphylactic ceeb). Yog li, txhawm rau tiv thaiv cov xwm txheej zoo li no, kuaj qhov ua tau zoo ua ntej siv Detemir.
4. Lub zos qhov kev qhiaCov. Lawv yog vim muaj tshwm sim ntawm daim tawv nqaij mus rau kev tswj hwm ntawm cov tshuaj. Lawv raug pom ntawm qhov chaw txhaj tshuaj - thaj chaw no tuaj yeem liab, qee zaum muaj mob tawm pob me ntsis. Zoo sib xws li ib txwm muaj tshwm sim hauv thawj theem ntawm cov tshuaj.

Nws tsis tuaj yeem hais meej tias ib feem twg ntawm cov tshuaj tuaj yeem ua rau kev haus ntau dhau, vim qhov no nyob ntawm tus neeg yam ntxwv. Yog li, txhua tus neeg mob yuav tsum ua raws li cov lus qhia los ntawm kws kho mob.

Tus naj npawb ntawm cov neeg mob uas tau ntsib ntau dua ib ntu ntawm cov ntshav qog ntshav qab zib thaum lub sijhawm kho nrog Detemir insulin lossis Glargin insulin

Cov lus qhia tshwj xeeb thiab cov tshuaj sib cuam tshuam

Siv cov tshuaj no yuav tsum muaj qee qhov kev ceev faj.

Txhawm rau txhawm rau kho cov kab mob kom zoo thiab nyab xeeb, yuav tsum ua raws li txoj cai hauv qab no:

1. Tsis txhob siv cov tshuaj no rau ntshav qab zib rau menyuam yaus hnub nyoog qis dua 6 xyoo.
2. Tsis txhob hla pluas noj (muaj qhov pheej hmoo ntawm lub qog ntshav qab zib).
3. Tsis txhob overdo nws nrog kev qoj ib ce (qhov no ua rau qhov tshwm sim ntawm lub xeev hypoglycemic).
4. Nco ntsoov tias vim kis tau tus kab mob kis, lub cev xav tau cov tshuaj insulin yuav nce siab.
5. Tsis txhob tswj cov tshuaj qhov ntswg (hauv qhov no, mob ntshav qab zib tsawg tshwm sim).
6. Nco ntsoov qhov tseem ntawm qhov hnov ​​lus tsis zoo thiab cov tshuaj tiv thaiv tus nqi ntawm hypo- thiab hyperglycemia.

Tus neeg mob yuav tsum paub txog tag nrho cov yam ntxwv no thiaj li ua tiav txoj kev kho mob.

Vim tias siv tshuaj los ntawm qee pawg, qhov cuam tshuam ntawm Detemir insulin yog distorted.

Feem ntau, cov kws kho mob nyiam tso tseg rau cov kev sib txuas, tab sis qee zaum qhov no ua tsis tau. Hauv cov xwm txheej zoo li no, kev ntsuas kev ntsuas ntawm cov tshuaj hauv cov lus nug tau muab.

Nws yog ib qho tsim nyog yuav tau nce lub koob tshuaj thaum noj nws nrog cov tshuaj xws li:

• sympathomimetics
• glucocorticosteroids,
• tshuaj kho mob
• tshuaj npaj rau pov thaiv,
• ib feem ntawm cov tshuaj tiv thaiv kab mob, thiab lwm yam.

Cov tshuaj no txo ​​cov hauj lwm zoo ntawm cov tshuaj insulin.

Cov koob tshuaj txo qis feem ntau yog siv thaum noj ua ke nrog cov tshuaj hauv qab no:

• tetracyclines
• carbonic anhydrase inhibitors, ACE, MAO,
• cov kab mob hypoglycemic
• anabolic tshuaj yuam
• beta blockers,
• cov tshuaj muaj cawv.

Yog tias koj tsis kho cov tshuaj ntawm cov tshuaj insulin, kev noj cov tshuaj no tuaj yeem ua rau kev mob ntshav qab zib tsawg.

Qee zaum tus neeg mob tau yuam kom ntsib tus kws kho mob kom hloov ib qho tshuaj nrog lwm tus. Cov laj thawj rau qhov no yuav txawv (tshwm sim ntawm kev mob tshwm sim, tus nqi siab, kev tsis yooj yim ntawm kev siv, thiab lwm yam). Muaj ntau yam tshuaj uas ua yeeb yaj kiab ntawm Detemir insulin.

Cov no suav nrog:

Cov tshuaj no muaj cov nyhuv zoo sib xws, yog li lawv siv feem ntau los hloov chaw. Tab sis ib tus neeg nrog rau kev paub thiab kev paub tsim nyog yuav tsum xaiv cov npe kom cov tshuaj tsis muaj kev phom sij.

Tus nqi ntawm Levemir Flexpen (lub npe lag luam ntawm Detemir) ntawm Danish ntau lawm yog los ntawm 1 390 txog 2 950 rubles.

Kws Tshuaj

"Detemir" suav hais tias yog ib qho yooj yim ib qho ntawm tib neeg ntawm cov tshuaj insulin, tus cwj pwm los ntawm cov nyhuv ntev ntev, daim ntawv qhia ncaj qha. Cov tshuaj khi rau cov kev txais tshwj xeeb, pub kom rov ua dua tshiab ntawm cov roj ntsha. Cov tshuaj insulin cuam tshuam cov piam thaj hauv cov metabolism, tswj nws. Cov tshuaj txo cov ntshav qab zib, piam thaj yog qhov zoo dua hauv cov ntaub so ntswg.

Yog tias cov tshuaj tau muab tshuaj ob zaug hauv 24 teev, ces nws muaj peev xwm ua tiav qhov kev sib txuam hauv cov ntshav tom qab txog 2-3 koob. Lub cev ntawm txhua tus neeg yog tus cwj pwm los ntawm tus neeg cov yam ntxwv ntawm kev nqus "Detemir, tab sis, feem ntau, nws qis dua piv nrog lwm cov tshuaj hloov pauv, tsis txhob ua si.

"Detemir" tsis cuam tshuam nrog cov roj ntsha, cov tshuaj uas txuam nrog cov protein. Lub sijhawm tshem tawm zaum kawg yog nyob ntawm kev haus tshuaj, kom tus nqi nqus los ntawm cov nqaij mos subcutaneous. Nws yog kwv yees li 5-7 teev.

"Detemir" muaj cov yeeb yam nram qab no:

• stimulation ntawm qabzib nqus nyob rau hauv hlwb, peripheral cov ntaub so ntswg,
• piam thaj metabolism tswj,
• txhim kho synthesis protein
• inhibition ntawm glucogenesis.

Los ntawm kev tswj cov txheej txheem no, qabzib yog txo. Tom qab rho tawm, qhov kev txiav txim tseem ceeb yuav pib tsuas yog tom qab 6 teev.

Hauv kev hais txog ib qho tshuaj insulin, yuav tsum ua raws li cov lus qhia kom nruj. Nws yog ib qho tsim nyog yuav tsum ua tib zoo kawm cov lus qhia, nws yog ib qho tseem ceeb kom ua tiav kev teem caij ntawm tus kws kho mob. Cov txiaj ntsig ntawm kev kho ntawm tus mob yog nyob ntawm qhov tseeb ntawm qhov kev ntsuas ntawm lub tsev kho mob pathology. Hauv qhov no, ntau npaum li cas ntawm cov tshuaj, lub sijhawm ntawm lub koom haum ntawm kev txhaj tshuaj yog txiav txim siab.

Kev siv "Detemir" yog tsim rau mob ntshav qab zib. Ntshav qab zib yog hom thawj lossis hom thib ob. Qhov txawv yog tias nyob rau hauv thawj, cov tshuaj tau qhia rau kev kho mob monotherapy, hauv ob - nws tau ua ke nrog lwm tus. Muaj kev zam vim yog qee qhov ntawm tus kheej ntawm tus neeg mob thiab nws cov kab mob.

Daim ntawv thov, txhaj tshuaj ntawm "Detemir"

Cov tshuaj tuaj yeem siv tsuas yog ib txoj hauv kev - qhov no yog kev txhaj tshuaj subcutaneous. Kev txhaj tshuaj rau hauv lub cev yog qhov txaus ntshai vim qhov kev nqis tes ua ob peb zaug. Hauv cov yeeb yaj kiab no, kev mob ntshav qab zib siab hnyav zuj zus.

Kev noj tshuaj yog txiav txim los ntawm kws kho mob, coj mus rau hauv tus account lub yam ntxwv ntawm tus neeg mob lub cev. Ib qho kev hloov pauv ntawm cov tshuaj uas raug xaiv yog xav tau thaum lub khoom noj khoom haus ntawm cov ntshav qab zib hloov pauv, kev ua haujlwm ntawm lub cev nce ntxiv, thiab cov kab mob mus ntxiv. "Detemir" yog siv los ua tshuaj rau monotherapy, ua ke nrog cov tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj.

"Detemir" qhia thaum lub sijhawm yooj yim rau ib tus neeg, tab sis tom qab teeb tsa lub sijhawm, koj yuav tsum ua raws li lub sijhawm txhua hnub. Cov hno tshuaj tau muab tshuaj subcutaneously nyob rau sab xub ntiag ntawm peritoneum, ncej puab, xub pwg, pob tw, thiab hauv cov leeg nqaij deltoid.

Cov chaw txhaj tshuaj yuav tsum tau hloov ua ntu zus los txhawm rau tiv thaiv lipodystrophy. Raws li thaum kho nrog lwm cov tshuaj insulin ntawm cov laus, cov neeg muaj lub raum thiab mob siab, nws yog qhov yuav tsum tau soj ntsuam cov piam thaj hauv cov ntshav tsis tu ncua. Nws yog ib qho tsim nyog yuav tau hloov kho qhov koob tshuaj ib tus zuj zus. Thawj thawj zaug tom qab teem caij "Detemir" nws yog ib qho tseem ceeb uas tswj cov piam thaj tshwj xeeb yog ua tib zoo. Txoj kev kho mob tsis pab txhawb nqa rau qhov hnyav.

Cov Kev Txwv

Rau qee tus neeg mob, Detemir tsuas yog kho nyob rau hauv kev saib xyuas kev kho mob tas li, nrog ceev faj. Qhov no yog qhov tsim nyog nyob rau hauv cov lus qhia. "Detemir" tuaj yeem siv nrog kev ceev faj thiab tom qab hloov kho koob tshuaj yog raug rau cov neeg mob uas muaj kev cuam tshuam ntxiv hauv lub cev:

• teeb meem hauv kev ua haujlwm ntawm lub siab ua haujlwm, vim tias lawv tuaj yeem cuam tshuam kev ua haujlwm ntawm cov khoom tseem ceeb ntawm Detemir,
• malfunctions ntawm ob lub raum - lub hauv paus ntsiab lus ntawm cov nyhuv ntawm tshuaj hloov pauv,
• lub hnub nyoog dhau los - tom qab 65 xyoo hauv lub cev, ntau yam kev hloov pauv nrog kev laus pib, cov kabmob ua haujlwm tsis tshua muaj siab, yog li qhov ntau npaum li cas tuaj yeem raug txo kom thiaj li tsis muaj teebmeem.

Sab sij huam

Ib qho insulin, suav nrog Detemir, tuaj yeem ua rau muaj kev phiv tshuaj mus rau kom tsawg. Qee zaum lawv pib tsim kho lub sijhawm luv luv, thaum lub cev tseem tsis tau muaj sijhawm los yoog cov teebmeem ntawm cov tshuaj. Hauv lwm cov xwm txheej, tag nrho cov sab cuam tshuam nrog cov tsis paub qhov tseeb contraindications thiab kev siv ntau tshaj.

Cov kev xav tsis zoo tuaj yeem ua rau muaj kev phom sij txaus ntshai, tsis tshua muaj neeg tuag taus.

Nws yog ib qho tseem ceeb uas yuav tau qhia tus mob mus rau tus kws kho mob kom raws sijhawm. Cov kev phiv nrog:

• hypoglycemia - poob rau hauv cov ntshav qab zib, uas muaj cov txiaj ntsig tsis zoo rau kev noj qab nyob zoo,
• mob taub hau
• tshee hnyo
• xeev siab
• lub plawv dhia
• tsaus muag.

Nrog rau qhov kev mob siab rau cov ntshav ntau ntau, yuav tsum tau txais kev saib xyuas kub ntxhov, txwv tsis pub hloov kho lub hlwb ntawm cov qauv hauv lub hlwb.

Raws li muaj teeb meem, cov kab mob pom feem ntau raug kev txom nyem. Feem ntau muaj ntshav qab zib yog nrog los ntawm retinopathy.

Kev ua xua kuj siv rau cov phiv - liab ntawm daim tawv nqaij, tawm pob, nce mus txog qhov tsis nco qab. Kev tshuaj ntsuam qhov tseeb yuav pab tiv thaiv kom tsis txhob muaj qhov tsis zoo.

Cov kev tsis zoo tshwm sim suav nrog cov tsos ntawm daim tawv nqaij ntawm qhov chaw txhaj tshuaj - nws hloov tawm liab, qee zaum o me ntsis. Qhov no tshwm sim ntau dua thaum ntxov ntawm kev kho mob.

Kev sib txuam

Qee yam tshuaj ua rau koj xav tau cov tshuaj insulin. Cov nyhuv hypoglycemic yog tsis muaj zog los ntawm:

• tshuaj tiv thaiv rau kev siv sab hauv,
• glucocorticosteroids,
• cov thyroid hormones nrog iodine,
• calcium channel blockers,
• diuretics ntawm thiazide pawg,
• heparin
• kev loj hlob lawm,
• sympathomimetics
• morphine
• tshuaj tiv thaiv kab mob
• nicotine.

Cov nyhuv ntshav tsis haum ntawm Detemir txhaj tshuaj yog txhim kho los ntawm kev sib txuam nrog:

• hypoglycemic cov neeg sawv cev rau kev tswj hwm qhov ncauj,
• cov enzymes
• tsis-xaiv beta-blockers,
• anabolic tshuaj yuam
• tetracyclines
• pyridoxine
• lithium npaj
• npaj nrog ethanol nyob rau hauv muaj pes tsawg leeg.

Cawv dej cawv muaj peev xwm ntxiv, nce ntxiv qhov xav tau ntawm insulin. Cov tshuaj los ntawm thiol, sulfite pawg rhuav tshem cov kua dej. Cov tshuaj tsis haum rau kev lis ntshav.

Noj ntau dhau

Qhov tshwj xeeb ntim ntawm insulin provoking ib qho kev tshaj dhau lawm tsis tau tsim, qhov ntau npaum yog tus neeg. Kev mob ntshav qab zib feem ntau tsis tshwm sim tam sim ntawd, tab sis tshwm sim txuas ntxiv nrog kev qhia kom txhaj ntau rau cov neeg mob tshwj xeeb.

Kev txo ntshav me me tuaj yeem nres ntawm nws tus kheej. Ua li no, tsuas yog haus dej qabzib, noj ib qho piam thaj, qee yam qab zib, nplua nuj hauv carbohydrates. Vim li no, cov neeg muaj ntshav qab zib muaj nyob tom qab ntawm tes - kua qab zib, qab zib, khaub noom.

Hauv kev tawm tsam hnyav, yog tias tus neeg tsis nco qab lawm, tswj kev noj qab haus huv ntawm 0.5-1 mg ntawm glucagon yuav tsum muaj, qabzib infusion yog qhov tsim nyog. Thaum tus neeg mob tsis rov qab nco qab ib hlis plaub teev tom qab glucagon, yuav tsum muaj piam thaj.

Txhawm rau tiv thaiv kom tsis txhob rov ua rau lub cev tsis zoo, koj yuav tsum tau noj tej yam nplua nuj nyob hauv cov carbohydrates.

Kev xaiv Analog

Qee zaum tus mob ntshav qab zib tau raug yuam kom nug tus kws kho mob txog kev hloov pauv tshuaj insulin nrog ib qho tshuaj tiv thaiv kab mob. Cov laj thawj txawv: kev phiv, tus nqi siab, kev tsis yooj yim ntawm kev siv. Ntau yam hloov pauv lub npe hu ua Detemir. Qhov nrov tshaj plaws yog qhia nyob rau hauv lub rooj.

Cov tshuaj zoo sib xws hauv kev nqis tes ua, yog li lawv feem ntau hloov kev sib txuam. Tab sis tsuas yog tus kws tshaj lij yuav tsum xaiv, thiaj li tsis muaj teeb meem.

Kuv yog tus uas mob ntshav qab zib"Detemir" pab kuv txo cov ntshav qab zib, thaum nws tsis ua rau muaj kev phiv, tsis zoo li hom insulin yav dhau los. Qhov tseem ceeb uas tus kws kho mob tham txog yog ib txwm ua raws tib lub sijhawm uas nkag, tsis txhob siab tshaj lossis txo qhov koob.

Kuv muaj ntshav qab zib hom 1 txij li 22 xyoos, Kuv siv lwm hom tshuaj insulin ua ntej, tab sis tsis ntev los no kws kho mob tau hais tseg"Detemir." Cov tshuaj ua kom sib npaug, cov nyhuv tsuas kav ntev li 24 teev. Qhov pom zoo ntawm cov tshuaj yog qhov zoo, Kuv tau siv nws ntau dua 3 lub lis piam.

Tus nqi ntawm "Detemir" muaj li ntawm 1300 txog 3000 rubles, tab sis hauv qee qhov chaw kho mob nws tuaj yeem nrhiav dawb, yog tias muaj cov ntawv sau tshuaj los ntawm nws mus rau tus kws kho mob hauv endocrinologist hauv Latin. "Detemir" ua tau zoo yog tias koj ua raws txhua cov lus qhia ntawm lub annotation, kev teem caij ntawm tus kws tshaj lij.

Xaus

"Detemir" yog soluble analogue ntawm tib neeg cov tshuaj insulin, muaj lub sijhawm ua ntev, ib daim ntawv qhia ncaj qha. Hauv lub neej niaj hnub, ntshav qab zib tsis yog kab lus. Tom qab tsim muaj cov tshuaj insulin, cov tib neeg ua lub neej puv ntoob. Nws yog ib qho tseem ceeb rau lawv los tswj xyuas lawv cov piam thaj kom tsis tu ncua, siv cov tshuaj tshwj xeeb raws li kws kho mob qhia.

Ntaub Ntawv

1. Antsiferov M. B., Dorofeeva L. G., Petraneva E. V. Siv cov tshuaj insulin glargine (Lantus) hauv kev kho mob ntshav qab zib mellitus (kev paub ntawm qhov kev pab cuam ntawm Moscow endocrinological) // Farmateka. 2005.V. 107. No. 12. P. 24–29.
2. Cryer P. E., Davies S. N., Shamoon H. Kev mob ntshav qab zib nyob hauv ntshav qab zib // Kev Tu Ntshav Qab Zib. Xyoo 2003, vol. 26: 1902-1912.
3. DeWitt D. E., Hirsch I. B. Kho cov ntshav sab nrauv nyob rau hauv hom 1 thiab hom 2 ntshav qab zib mellitus. Kev Tshawb Fawb Kev Tshawb Fawb // JAMA. Xyoo 2003, 289: 2254-2264.
4. Bethel M. A., Feinglos M. N. Insulin analog: cov kev kho tshiab rau hom 2 ntshav qab zib mellitus // Curr. Diab Kwv. Xyoo 2002, 2: 403–408.
5. Fritsche A., Hoering H., Toegel E., Schweitzer M. HOE901 / 4001 Pab Pawg Kawm. Kho-rau-phiaj nrog ntxiv-ntawm basal insulin - tuaj yeem muaj cov insulin glargin txo qis cov kev cuam tshuam rau kev ua kom tiav? // Mob ntshav qab zib. Xyoo 2003, 52 (muab. 1): A119.
6. Fritsche A. li al. Glimepiride ua ke nrog thaum sawv ntxov insulin glargin, pw hmo NPH insulin, lossis pw thaum hmo ntuj insulin glargine rau cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus. Kev sim tswj kev sim xaiv // Ann.Intern. Med. Xyoo 2003, 138: 952–959.
7. Herz M. li al. Pawg Kawm Txuj Mix25. Sib piv glycemic tswj nrog ua ntej noj mov tom qab noj mov ntawm Humalog Mix25 nyob rau hauv cov neeg laus cov neeg mob ntshav qab zib hom 2. Phau ntawv paub daws teeb meem: 61st kev tshawb fawb: Lub Rau Hli 22-26, 2001 hauv Philadelphia, Pennsylvania (USA) - Abstract 1823-PO.
8. Herz M., Arora V., Phiaj Xwm B. N. et al. Humalog Mix25 txhim kho 24-teev plasma glucose profiles piv nrog tib neeg cov tshuaj insulin sib xyaw 30/70 hauv cov neeg mob uas muaj ntshav qab zib hom 2 / // S.A.fr. Med. J. 2003, 93: 219–223.
9. Gerstein H. C., Yale J-F., Harris S. B. li al. / Ib qho kev sim ntawm kev siv tshuaj glargine thaum ntxov siv kom ua tiav qib A1c zoo hauv insulin Na_ve cov neeg mob ntshav qab zib hom 2 mellitus. Los ntawm 65th Kev Sib Tham Txhua Xyoo ntawm American Diabetes Association. San Diego, Califormia (USA). 2005.
10. Jacobsen L. V., Sogaard B., Riis A. Pharmacokinetics thiab chaw muag tshuaj ntawm ib qho kev tsim qauv ntawm kev ua kom muaj kuab lom thiab tiv thaiv cov tshuaj insulin aspart // Eur. J. Clin. Pharmacol. 2000, 56: 399-403.
11. Mattoo V., Milicevic Z., Malone J.K. li al. Rau Ramadan Kawm Pab Pawg. Kev sib piv ntawm insulin lispro Mix25 thiab insulin tib neeg 30/70 hauv kev kho mob hom 2 thaum Ramadan // Mob Ntshav Qab Zib Res. C / hauv Kev Coj Ua. Xyoo 2003, 59: 137–143.
12. Malone J. L., Kerr L. F., Phiaj Xwm B. N. et al. Rau Cov Lispro Sib Koom-Glargine Kawm Pab Pawg. Ua ke nrog kev kho mob nrog insulin Lispo Mix 75/25 ntxiv rau metformin lossis inslulin glargine ntxiv rau metformin: 16-lub lis piam, xaiv tau, qhib-daim ntawv lo, kawm txog cov neeg mob ntshav qab zib hom mob ntshav qab zib hom 2 pib insulin txoj kev kho mob // Clin. Ther. 2004, 26: 2034–2044.
13. Malone J. L., Bai S., Phiaj Xwm B. B. et al. Ob zaug-txhua hnub ua ntej cov tshuaj insulin ntau dua li cov tshuaj insulin kho mob ib leeg ua rau muaj kev tswj zoo glycemic nyob rau hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib // Diabet.Med. 2005, 22: 374–381.
14. Daim Npuag T. R., Plank J. Goerzer E. li al. Ntev ntawm kev nqis tes ua, pharmacodynamic profile thiab nruab nrab-cov ntsiab lus hloov pauv ntawm insulin detemir nyob rau hauv cov ncauj lus nrog hom 1 mob ntshav qab zib // Diabetologia. Xyoo 2002, 45 Tus Khw Muag Khoom 2: 254.
15. Roach P., Woodworth J. R. Cov chaw muag tshuaj thiab chaw muag tshuaj ntawm insulin lispro mixtures // Clin. Pharmacokinet. Xyoo 2002, 41: 1043-1057.
16. Roach P., Yue L., Arora V. Rau Pawg Kawm Sib Tham 25. Txhim kho postprandial glycemic tswj thaum lub sij hawm kho nrog Humalog Mix25, ib qho tshiab ntawm cov tshuaj tiv thaiv inslulin lispro formulation // Kev Tu Ntshav Qab Zib. Xyoo 1999, 22: 1258–1261.
17. Roach P., Trautmann M., Arora V. li al. Rau Pawg Kawm Hauv Mix25. Txhim kho postprandial ntshav qab zib tswj thiab txo qis nocturnal hypoglycemia thaum kho nrog ob lub tshiab insulin lispro-protamine formulations, insulin lispro mix25 thiab insulin lispro mix50 // Clin.Ther. Xyoo 1999, 21: 523-534.
18. Rolla A. R. Insulin analog sib xyaw ua ke hauv kev tswj hwm tus mob ntshav qab zib 2 mellitus // Pract.Diabetol. Xyoo 2002, 21: 36–43.
19. Rosenstock J., Schwarts S. L., Clark C. M. et al. Kev kho mob ntshav qab zib hom qis 2 hauv cov ntshav qab zib: 28-lub lim tiam sib piv ntawm insulin glargin (HOE 901) thiab NPH insulin // Ntshav Qab Zib Kho. Xyoo 2001, 24: 631-636.
20. Vague P., Selam J. L., Skeie S. et al. Insulin detemir yog txuam nrog kev paub ntau dua ntawm glycemic tswj thiab txo qhov kev pheej hmoo ntawm hypoglycaemia dua li NPH insulin hauv cov neeg mob uas muaj ntshav qab zib hom 1 ntawm cov kab mob basal-bolus nrog cov tshuaj premeal insulin aspart // Kev Tu Ntshav Qab Zib. Xyoo 2003, 26: 590-596.

A. M. Mkrtumyan, Kws Kho Mob Kev Tshawb Fawb ntawm Kev Tshawb Fawb, kws kho mob
A. N. Oranskaya, neeg sib tw ntawm kev kho mob sciences
MGMSU, Moscow

Pharmacological kev txiav txim ntawm cov quav yeeb tshuaj

Detemir insulin yog tsim tawm siv cov roj av deoxyribonucleic acid (DNA) biotechnology siv tshuaj tua kab mob hu ua Saccharomyces cerevisiae.

Cov tshuaj insulin yog cov tshuaj tseem ceeb ntawm cov tshuaj Levemir flekspen, uas tau tawm hauv qhov tsim ntawm kev daws hauv kev yooj yim 3 ml syringe cwjmem (300 PIECES).

Qhov no tib neeg cov tshuaj hormones analogue khi rau peripheral cell receptors thiab ua rau cov txheej txheem lom.

Tib neeg cov tshuaj insulin pab txhawb kev ua kom muaj kev ua haujlwm hauv qab no hauv lub cev:

• stimulation ntawm qabzib uptake los ntawm peripheral hlwb thiab cov ntaub so ntswg,
• piam thaj metabolism tswj,
• inhibition of gluconeogenesis,
• nce protein synthesis
• kev tiv thaiv ntawm lipolysis thiab tiv thaiv proteolysis hauv cov rog rog.

Ua tsaug rau tag nrho cov txheej txheem no, muaj kev txo cov ntshav qab zib kom tsawg. Tom qab txhaj cov tshuaj insulin, Detemir ncav cuag nws cov txiaj ntsig zoo tshaj plaws tom qab 6-8 teev.

Yog tias koj nkag rau qhov kev daws teeb meem ob zaug hauv ib hnub, tom qab ntawv qhov sib luag ntawm cov tshuaj insulin tiav tom qab ob lossis peb qhov kev txhaj tshuaj no. Kev txiav txim siab ntawm ib tug neeg sab hauv ntawm Detemir insulin yog qis dua lwm qhov ntawm lwm cov tshuaj los ntawm insulin.

Qhov tshuaj no muaj cov nyhuv tib yam rau txiv neej thiab poj niam. Nws qhov kev faib khoom nruab nrab yog kwv yees li 0.1 l / kg.

Lub sijhawm kawg ntawm ib nrab-lub neej ntawm insulin txhaj nyob rau hauv daim tawv nqaij yog nyob ntawm kev ntau npaum li cas ntawm cov tshuaj thiab yog kwv yees li 5-7 teev.

Cov lus qhia rau kev siv tshuaj

Tus kws kho mob suav qhov ntau npaum li cas ntawm cov tshuaj, noj mus rau hauv tus account lub concentration ntawm cov piam thaj hauv ntshav qab zib.

Cov koob tshuaj yuav tsum raug kho nyob rau hauv cov ntaub ntawv ntawm kev ua txhaum ntawm tus neeg mob lub cev noj mov, nce kev ua si lossis muaj lwm yam txuj ci. Insulin Detemir tuaj yeem siv los ua cov tshuaj tseem ceeb, ua ke nrog bolus insulin los yog nrog cov tshuaj txo cov ntshav qab zib.

Qhov kev txhaj tshuaj tuaj yeem ua tsis pub dhau 24 teev nyob rau txhua lub sijhawm, qhov tseem ceeb tshaj plaws yog soj ntsuam tib lub sijhawm txhua hnub. Cov kev cai yooj yim rau kev tswj hwm cov tshuaj hormones:

1. Qhov kev txhaj tshuaj yog tsim nyob rau hauv daim tawv nqaij mus rau hauv thaj chaw hauv plab, xub pwg, pob tw lossis ncej puab.
2. Txhawm rau kom txo kev ntxim nyiam ntawm lipodystrophy (mob nqaij ntshiv nqaij), thaj chaw txhaj tshuaj yuav tsum tau hloov ua ntu zus.
3. Cov neeg muaj hnub nyoog tshaj 60 xyoo thiab cov neeg mob raum lossis lub siab ua rau lub siab xav soj ntsuam cov kua nplaum thiab kho cov tshuaj insulin ntau dua.
4. Thaum hloov pauv ntawm lwm cov tshuaj lossis hauv thawj theem ntawm txoj kev kho, nws yog qhov yuav tsum tau ua tib zoo saib xyuas theem ntawm glycemia.

Nws yuav tsum raug sau tseg tias hauv kev kho mob ntawm cov tshuaj insulin Detemir tsis xav tau qhov nce hauv qhov hnyav ntawm tus neeg mob. Ua ntej taug kev ntev ntev, tus neeg mob yuav tsum sab laj nrog tus kws kho mob tshwj xeeb txog kev siv cov tshuaj, txij li hloov lub sijhawm ib cheeb tsam cuam tshuam cov sijhawm teem rau tshuaj insulin.

Kev txiav tawm ntawm txoj kev kho kom zoo tuaj yeem ua rau lub xeev ntawm hyperglycemia - nce qib ntawm cov piam thaj ntau, lossis tseem muaj ketoacidosis mob ntshav qab zib - kev ua txhaum ntawm cov carbohydrate metabolism vim tsis muaj cov tshuaj insulin. Yog tias tus kws kho mob tsis tiv tauj sai, qhov yuav ua rau tuag tau tshwm sim.

Kev mob hypoglycemia yog tsim thaum lub cev qias lossis tsis txaus noj nrog cov zaub mov, thiab cov koob tshuaj insulin, nyeg, yog qhov siab heev. Txhawm rau txhawm rau nce ntxiv cov piam thaj hauv cov ntshav, koj yuav tsum noj ib qho qab zib, qab chocolate, qee yam qab zib.

kub taub hau lossis ntau yam mob feem ntau nce ntxiv qhov kev xav tau ntawm lub cev. Qhov kev hloov kho ntawm txoj kev daws teeb meem yuav tsim nyog hauv kev txhim kho pathologies ntawm ob lub raum, mob siab, lub qog, cov qog pituitary thiab cov qog adrenal.

Thaum muab cov tshuaj insulin thiab thiazolidinediones, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv qhov tseeb tias lawv tuaj yeem pab txhawb kev txhim kho kev mob plawv thiab mob ntsws tsis ua hauj lwm.

Thaum siv yeeb tshuaj, kev hloov pauv hauv kev xav thiab psychomotor tus cwj pwm yog tau.

Cov txheej txheem ua pov thawj thiab ua rau muaj kev phom sij

Xws li, tsis muaj kev tiv thaiv kev siv rau cov tshuaj insulin Detemir. Cov kev txwv tsuas yog cuam tshuam rau cov tib neeg muaj kev ywj pheej rau cov tshuaj yeeb dej caw thiab ob xyoos vim qhov kev tshawb fawb txog kev cuam tshuam ntawm cov tshuaj insulin rau cov menyuam yaus tseem tsis tau ua.

Lub sijhawm nyob hauv menyuam yaus, kev siv tshuaj yeeb tuaj yeem siv, tab sis nyob hauv kev saib xyuas ntawm tus kws kho mob.

Ntau cov kev tshawb fawb tsis tau qhia tawm cov kev mob tshwm sim hauv niam thiab nws tus menyuam tshiab nrog kev qhia ntawm kev txhaj tshuaj ntawm insulin thaum nws xeeb tub.

Nws ntseeg tau tias cov tshuaj no tuaj yeem siv nrog niam mis, tab sis tsis muaj kev tshawb nrhiav. Yog li, rau cov niam cev xeeb tub thiab lactating, tus kws kho mob kho cov tshuaj ntawm cov tshuaj insulin, kev hnyav ua ntej nws muaj txiaj ntsig rau leej niam thiab muaj kev pheej hmoo rau nws tus menyuam.

Xws li rau qhov tsis zoo rau lub cev, cov lus qhia rau kev siv muaj ib daim ntawv teev ntau:

1. Ib lub xeev ntawm cov ntshav ntog lub cev muaj tus yam ntxwv xws li tsaug zog, txob taus, pallor ntawm daim tawv nqaij, tshee tshee, mob taub hau, tsis meej pem, nriaj teeb, tsaus muag, tachycardia. Qhov xwm txheej no tseem tseem hu ua insulin shock.
2. Cov tshuaj tiv thaiv ib ce hauv ib cheeb tsam - o thiab liab ntawm thaj chaw txhaj tshuaj, khaus, nrog rau cov tsos ntawm lipid dystrophy.
3. Kev ua xua, angioedema, urticaria, tawv nqaij ua pob thiab tawm hws.
4. Ua txhaum ntawm lub plab zom mov - xeev siab, ntuav, mob plab, raws plab.
5. Ua tsis taus pa, ua kom ntshav siab.
6. Pom kev tsis pom kev - qhov hloov ntawm qhov tsis txaus siab uas ua rau retinopathy (mob ntawm qhov mob ntawm qhov retina).
7. Kev tsim tawm ntawm cov hlab hlwb paj hlwb.

Kev noj tshuaj ntau dhau hle tuaj yeem ua rau kom qab zib poob sai heev. Nrog cov ntshav qog ntshav qab zib tsawg, tus neeg yuav tsum haus cov khoom muaj protein ntau.

Hauv kev mob nyhav rau tus neeg mob, tshwj xeeb yog nws tsis nco qab lawm, yuav tsum tau mus pw hauv tsev kho mob sai. Tus kws kho mob txhaj ib qho kua nplaum los sis glucagon hauv qab ntawm daim tawv nqaij lossis hauv qab cov leeg nqaij.

Thaum tus neeg mob rov qab, nws tau muab ib qho qab zib los yog chocolate ua los tiv thaiv nws cov piam thaj kom pheej rov qab los.

Nqi, tshuaj xyuas, txhais tau tias zoo ib yam

Cov tshuaj Levemir flekspen, cov tshuaj tiv thaiv uas yog insulin Detemir, muag hauv khw muag tshuaj thiab cov khw muag tshuaj online.

Koj tuaj yeem yuav cov tshuaj tsuas yog tias koj muaj daim ntawv sau tshuaj los ntawm kws kho mob.

Cov tshuaj yog kim heev, nws cov nqi sib txawv ntawm 2560 txog 2900 Lavxias rubles. Hauv qhov no, tsis yog txhua tus neeg mob tuaj yeem them nws.

Txawm li cas los xij, kev txheeb xyuas ntawm Detemir insulin yog qhov zoo. Ntau tus neeg mob ntshav qab zib uas tau txhaj nrog tib neeg li cov tshuaj hormones tau sau tseg txog cov txiaj ntsig no:

• maj mam txo cov ntshav qab zib,
• tswj cov nyhuv ntawm cov tshuaj rau txog ib hnub,
• yooj yim ntawm kev siv syringe cwjmem,
• tsis tshua muaj tshwm sim ntawm kev phiv tshuaj,
• tswj qhov hnyav ntawm cov ntshav qab zib nyob rau tib theem.

Yuav kom ua tau ib qho txiaj ntsig qabzib tuaj yeem tsuas ua tau rau txhua txoj cai ntawm kev kho mob ntshav qab zib. Qhov no tsis tsuas yog cov tshuaj insulin, tab sis kuj ua kom ib ce zuaj zuaj ib ce, qee qhov kev txwv noj zaub mov thiab tswj ntshav qab zib kom ruaj. Ua raws li cov tshuaj kho tau yog qhov tseem ceeb, txij li qhov pib ntawm kev mob ntshav qab zib, nrog rau nws cov kev mob nyhav, raug cais tawm.

Yog tias cov tshuaj hauv qee qhov tsis haum tus neeg mob, tus kws kho mob yuav sau ntawv rau lwm cov tshuaj. Piv txwv, insulin Isofan, uas yog ib qho piv txwv ntawm tib neeg cov tshuaj hormones, uas yog tsim los ntawm kev tsim kho caj ces. Isofan tsis yog siv tsis yog mob ntshav qab zib mellitus ntawm thawj thiab thib ob hom, tab sis kuj tseem nyob hauv nws daim ntawv taw (hauv cov poj niam cev xeeb tub), intercurrent pathologies, nrog rau kev phais mob.

Nws lub sijhawm ntawm qhov kev txiav txim siab yog tsawg dua li ntawm Detemir insulin, txawm li cas los xij, Isofan tseem muaj qhov ua tau zoo hypoglycemic zoo. Nws muaj yuav luag tib qhov kev phiv tshuaj, lwm yam tshuaj tuaj yeem cuam tshuam nws cov hauj lwm zoo. Isofan tivthaiv muaj nyob hauv ntau cov tshuaj, piv txwv li, Humulin, Rinsulin, Pensulin, Gansulin N, Biosulin N, Insuran, Protafan thiab lwm yam.

Nrog rau kev siv txoj cai ntawm Detemir insulin, koj tuaj yeem tshem tawm cov tsos mob ntshav qab zib. Nws cov analogues, kev npaj kom muaj cov tshuaj insulin Isofan, yuav pab tau thaum kev siv cov tshuaj tsis txwv. Yuav ua li cas nws ua haujlwm thiab vim li cas koj xav tau insulin - hauv video hauv kab lus no.

Analogs hauv kev muaj pes tsawg leeg thiab qhia txog kev siv

Cov npe saum toj no ntawm cov yeeb tshuaj analogues, uas qhia cov tshuaj insulin hloov, yog qhov tsim nyog tshaj plaws vim tias lawv muaj tib cov tshuaj sib luag thiab sib luag ua ke raws li kev taw qhia rau kev siv

Insulin "Detemir": qhov kev piav qhia ntawm cov tshuaj

Cov tshuaj muaj nyob rau hauv daim ntawv tsis muaj xim pob tshab tov. Hauv 1 ml ntawm nws muaj cov khoom siv tseem ceeb - insulin detemir 100 PIECES. Tsis tas li ntawd, nws muaj lwm cov khoom ntxiv: glycerol, phenol, metacresol, zinc acetate, sodium hydrogen phosphate dihydrate, sodium chloride, hydrochloric acid q.s. los yog sodium hydroxide q.s., dej rau kev txhaj tshuaj txog li 1 ml.

Cov tshuaj muaj nyob rau hauv daim duab syringe, uas muaj 3 ml ntawm kev daws, ib qho sib npaug ntawm 300 PIECES. 1 ntu ntawm cov tshuaj insulin muaj 0.142 mg ntawm cov ntsev tsis muaj tshuaj tua kab mob insulin.

Detemir ua haujlwm li cas?

Detemir insulin (lub npe ua lag luam Levemir) yog tsim tawm siv cov roj av deoxyribonucleic acid (DNA) biotechnology siv hom tshuaj hu ua Saccharomyces cerevisiae. Cov tshuaj insulin yog qhov tseem ceeb ntawm Levemir flekspen thiab yog ib qho khoom noj tsis haum ntawm tib neeg cov tshuaj hormones uas khi rau peripheral cell receptors thiab ua kom tag nrho cov txheej txheem lom. Nws muaj ntau qhov kev ua ntawm lub cev:

• stimulates kev siv cov piam thaj los ntawm kev sib luag cov ntaub so ntswg thiab cov hlwb,
• tswj cov metabolism hauv qabzib,
• inhibits gluconeogenesis,
• nce protein synthesis,
• tiv thaiv lipolysis thiab proteolysis hauv cov rog rog.

Nws ua tsaug rau kev tswj hwm los ntawm tag nrho cov txheej txheem no uas cov ntshav qab zib kom tsawg. Tom qab kev qhia ntawm cov tshuaj, nws cov nyhuv tseem ceeb pib tom qab 6-8 teev.

Yog tias koj nkag mus nws ib hnub ob zaug, tom qab ntawd ua tiav kev sib npaug ntawm cov suab thaj tuaj yeem tiav tom qab ob mus rau peb koob. Cov tshuaj muaj tib yam nkaus rau tus poj niam thiab tus txiv neej. Nws qhov kev faib khoom nruab nrab yog nyob hauv 0.1 l / kg.

Ib nrab-lub neej ntawm insulin, uas tau txhaj rau hauv qab daim tawv nqaij, nyob ntawm qhov koob tshuaj thiab yog kwv yees li 5-7 teev.

Cov yam ntxwv ntawm kev ua ntawm cov tshuaj "Detemir"

Detemir insulin (Levemir) muaj kev cuam tshuam ntau dua li cov tshuaj insulin xws li Glargin thiab Isofan. Nws cov txiaj ntsig ntev ntawm lub cev yog vim muaj qhov tshwm sim tus kheej ntawm cov koom haum hauv cov qauv molecular thaum lawv dock nrog cov sab fatty acid saw nrog cov kab mob albumin. Piv nrog rau lwm cov insulins, nws disperses maj mam thoob plaws lub cev, tab sis vim qhov no, nws txoj kev nqus nws muaj zog dua. Tsis tas li, hauv kev sib piv nrog rau lwm cov kev sib piv, Detemir insulin yog qhov ua kom paub tseeb dua, thiab yog li nws yooj yim dua los tswj nws cov nyhuv. Thiab qhov no yog vim muaj ntau yam:

• cov khoom tseem nyob rau hauv lub xeev ua kua los ntawm lub sijhawm thaum nws yog nyob rau hauv lub cwj mem zoo li rab koob kom txog thaum nws tau nkag mus rau hauv lub cev,
• nws cov lus khi rau albumin lwg me me hauv cov ntshav cov los ntawm txoj kev tsis.

Cov tshuaj cuam tshuam rau cell loj hlob tus nqi tsawg, uas tsis tuaj yeem hais txog lwm yam insulins. Nws tsis muaj cov genotoxic thiab tshuaj lom rau hauv lub cev.

Yuav siv "Detemir" li cas?

Cov koob tshuaj ntawm cov tshuaj tau xaiv ib tus zuj zus rau txhua tus neeg mob ntshav qab zib. Koj tuaj yeem nkag mus nws ib zaug lossis ob zaug hauv ib hnub, qhov no tau qhia los ntawm kev qhia. Cov lus pov thawj ntawm kev siv Detemir insulin siv thov tias yuav ua kom txoj kev tswj ntawm glycemia, kev txhaj tshuaj yuav tsum tau txhaj ob zaug ib hnub: thaum sawv ntxov thiab yav tsaus ntuj, tsawg kawg 12 teev yuav tsum ncua ntawm kev siv.

Rau cov neeg laus uas muaj ntshav qab zib thiab cov uas muaj mob siab thiab siab lub raum tsis ua hauj lwm, cov koob tshuaj yog xaiv nrog ceev faj.

Cov tshuaj insulin yog txhaj rau hauv qab ntawm lub xub pwg, tus ncej puab thiab thaj av hauv thaj chaw. Lub zog ntawm kev nqis tes ua yog nyob ntawm qhov twg tshuaj. Yog tias qhov kev txhaj tshuaj tau ua rau hauv ib thaj chaw, tom qab ntawd qhov chaw hno tuaj yeem hloov tau, piv txwv li, yog tias cov tshuaj insulin txhaj rau hauv daim tawv nqaij ntawm lub plab, ces qhov no yuav tsum tau ua 5 cm los ntawm cov ntaws thiab hauv lub voj voos.

Nws yog ib qho tseem ceeb kom tau txais kev txhaj tshuaj kom yog. Txhawm rau ua qhov no, koj yuav tsum coj tus cwj mem syringe nrog chav kub tshuaj, tshuaj tua kab mob thiab ntaub paj rwb.

Thiab nqa tawm cov txheej txheem raws li nram no:

• kho thaj chaw puncture nrog kev siv tshuaj tua kab mob thiab tso cai rau daim tawv nqaij kom qhuav,
• daim tawv nqaij tau ntes hauv lub pob taws
• lub koob yuav tsum tau muab tso rau ntawm lub kaum sab xis, tom qab ntawd lub piston rub tawm rov qab me ntsis, yog tias pom muaj ntshav, lub nkoj raug puas lawm, qhov chaw txhaj tshuaj yuav tsum tau hloov,
• cov tshuaj yuav tsum tau muab tshuaj qeeb qeeb thiab ua kom sib luag, thaum lub piston txav nrog qhov nyuaj, thiab ntawm qhov chaw raug mob ntawm daim tawv nqaij yog inflated, lub koob yuav tsum tau ntxig tob,
• tom qab kev tswj hwm tshuaj, nws yog qhov yuav tsum tau ua kom ntev rau 5 feeb, tom qab ntawd cov koob txhaj tshuaj yog tshem nrog qhov txav, thiab qhov chaw txhaj tshuaj yog kho nrog antiseptic.

Txhawm rau txhawm rau txhawm rau kom tsis muaj kev phom sij, rab koob yuav tsum ua kom nyias li qhov ua tau, daim tawv nqaij yuav tsum tsis txhob zawm, thiab txhaj yuav tsum tau ua nrog tus paub txhais tes tsis muaj kev ntshai thiab ua xyem xyav.

Yog hais tias tus neeg mob txhaj ob peb hom tshuaj insulin, ces ua ntej yog ntaus luv, thiab tom qab ntawd ntev.

Dab tsi los saib rau ua ntej nkag mus rau Detemir?

Ua ntej kev txhaj tshuaj, koj yuav tsum:

• xyuas ob npaug ntawm cov nyiaj
• tsau tshuaj rau daim nyias nyias nrog tshuaj tua kab mob,
• ua tib zoo saib xyuas qhov ncaj ncees ntawm daim cartridge, yog tias dheev nws puas ntsoog lossis muaj kev ua xyem xyav txog nws txoj kev tsim nyog, ces koj tsis tas yuav siv nws, koj yuav tsum xa nws mus rau lub tsev muag tshuaj.

Nws yog tsim nyog kom nco ntsoov tias nws yog nruj me ntsis txwv tsis pub siv cov roj ntsha Detemir khov lossis ib qho uas tau khaws cia tsis raug. Hauv tshuaj insulin twj, cov tshuaj tsis yog siv, nrog kev qhia nws yog ib qho tseem ceeb kom soj ntsuam ntau txoj cai:

• xeem tsuas yog nyob rau hauv daim tawv nqaij,
• lub koob hloov tom qab txhaj txhua,
• lub cav ntim tsis puv.

Nyob rau hauv dab tsi raug yog cov tshuaj contraindicated?

Ua ntej siv Detemir, nws yog ib qho tseem ceeb kom paub txog thaum nws yog nruj me ntsis contraindicated:

• yog tias tus neeg mob muaj qhov tsis sib haum xeeb ntawm cov tshuaj, nws tuaj yeem txhim kho kev fab tshuaj, qee qhov kev tuaj yeem tuaj yeem ua rau tuag taus,
• rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, cov tshuaj no tsis raug pom zoo, nws tsis tuaj yeem kuaj xyuas nws cov nyhuv rau menyuam, yog li ntawd nws tsis tuaj yeem twv seb nws yuav cuam tshuam licas rau lawv.

Tsis tas li ntawd, tseem muaj cov pawg zoo li no ntawm cov neeg mob uas raug tso cai siv tshuaj nyob hauv kev kho mob, tab sis nrog kev saib xyuas tshwj xeeb thiab kev saib xyuas tas li. Qhov no yog qhia los ntawm cov lus qhia rau kev siv. Cov tshuaj Insulin "» hauv cov neeg mob uas muaj cov kab mob, kev kho kom haum yuav tsum muaj:

• Kev ua txhaum nyob rau hauv daim siab. Yog tias cov ntawv tau piav qhia hauv tus neeg mob lub keeb kwm, ces qhov kev ua ntawm lub ntsiab feem yuav cuam tshuam, yog li cov koob tshuaj yuav tsum tau kho.
• Ua tsis tiav hauv lub raum. Nrog cov txuj ci zoo li no, lub hauv paus ntsiab lus ntawm kev ua yeeb tshuaj tuaj yeem hloov pauv, tab sis cov teeb meem yuav daws tau yog tias koj soj ntsuam tus neeg mob tas li.
• Qub neeg. Tom qab lub hnub nyoog ntawm 65, muaj ntau yam kev hloov pauv hauv lub cev, uas tuaj yeem nyuaj rau kev taug qab. Hauv lub hnub nyoog laus, cov kabmob no tsis ua haujlwm zoo li hauv cov hluas, yog li ntawd, nws yog qhov tseem ceeb rau lawv xaiv cov tshuaj kho mob kom nws thiaj li pab tau cov ntshav qabzib ntau, thiab tsis raug mob.

Yog tias koj coj mus rau hauv tus account tag nrho cov lus qhia, tom qab ntawd qhov kev pheej hmoo ntawm qhov tsis zoo tuaj yeem txo.

"Detemir" thaum cev xeeb tub thiab thaum pub niam mis

Ua tsaug rau cov kev tshawb fawb txog seb kev siv cov tshuaj insulin "Detemira» tus poj niam cev xeeb tub thiab nws tus me nyuam hauv plab, nws tau raug pov thawj pom tias cov cuab yeej tsis cuam tshuam rau txoj kev loj hlob ntawm tus menyuam. Tab sis yuav hais tias nws muaj kev nyab xeeb kiag li, nws tsis yooj yim sua, vim hais tias thaum lub sijhawm cev xeeb tub muaj kev hloov pauv hauv tus poj niam lub cev, thiab cov tshuaj yuav ua li cas hauv qee kis tsis tuaj yeem kwv yees. Tias yog vim li cas cov kws kho mob, ua ntej sau ntawv rau nws thaum cev xeeb tub, ntsuas qhov txaus ntshai.

Thaum kho, koj yuav tsum tau saib xyuas cov qib ntawm cov piam thaj kom tas li. Qhov ntsuas tuaj yeem hloov pauv tau ntau, yog li kev saib xyuas raws sij hawm thiab txhaj tshuaj hloov kho yog qhov tsim nyog.

Nws tsis tuaj yeem hais meej meej tias qhov tshuaj nkag mus rau leej niam mis, tab sis txawm tias nws tau txais, nws ntseeg tau tias nws yuav tsis nqa teeb meem.

Cov lus qhia tshwj xeeb rau kev siv

Cov lus qhia rau insulin "Detemir" ceeb toom tias kev siv tshuaj yuav tsum muaj kev ceev faj tshwj xeeb. Txhawm rau kev kho mob kom ua rau cov txiaj ntsig xav tau thiab muaj kev nyab xeeb, koj yuav tsum ua raws li cov cai no:

• tsis txhob siv cov tshuaj hauv kev kho mob ntawm cov menyuam muaj hnub nyoog qis dua 6 xyoo,
• tsis txhob noj mov, muaj kev pheej hmoo ntawm hypoglycemia,
• tsis txhob tsim txom lub cev,
• nco ntsoov nqa mus rau hauv tus account tias vim yog txoj kev txhim kho ntawm kev kis mob, lub cev yuav xav tau ntau yam insulin,
• tsis txhob tswj cov tshuaj leeg ntawd,
• Nco ntsoov tias tus nqi ntawm cov tshuaj tiv thaiv thiab qhov tsis hnov ​​zoo tuaj yeem hloov pauv yog tias hyper- thiab hypoglycemia tshwm sim.

Txhawm rau rau kev kho mob mus rau qhov yog, txhua tus neeg mob ntshav qab zib siv tshuaj insulin yuav tsum paub txoj cai. Tus kws kho mob uas koom nrog yuav tsum muaj kev sib tham, piav qhia tsis yog tsuas yog yuav ua li cas thiaj txhaj thiab ntsuas ntshav qab zib, tab sis kuj tham txog kev hloov pauv ntawm kev ua neej thiab kev noj haus.

Analogues ntawm cov tshuaj

Qee tus neeg mob yuav tsum tau nrhiav rau Detemir insulin analogues nrog kev sib sau ua ke ntawm lwm cov khoom siv. Piv txwv, cov ntshav qab zib uas muaj kev tsis haum xeeb rau cov feem ntawm cov tshuaj no. Muaj ntau ntau cov yeeb yaj kiab ntawm Detemir, suav nrog Insuran, Rinsulin, Protafan thiab lwm yam.

Tab sis nws yog tsim nyog kom nco ntsoov tias qhov analogue nws tus kheej thiab nws txoj kev noj tshuaj yuav tsum raug xaiv los ntawm tus kws kho mob hauv txhua kis ntawm tus kheej. Qhov no siv rau ib qho tshuaj twg, tshwj xeeb nrog rau txoj kev loj.

Tus nqi tshuaj

Tus nqi ntawm insulin Detemir Danish ntau lawm yog los ntawm 1300-3000 rubles. Tab sis nws yog tsim nyog nco ntsoov tias koj tuaj yeem tau txais nws dawb, tab sis qhov no, koj yuav tsum twv yuav raug muaj cov lus Latin sau los ntawm endocrinologist. Detemir insulin yog ib qho tshuaj zoo rau kev kho mob ntawm hom 1 thiab ntshav qab zib hom 2, qhov tseem ceeb yog ua raws li txhua qhov kev pom zoo, thiab nws yuav tsuas yog muaj txiaj ntsig rau cov ntshav qab zib.

Kev Ntsuam Xyuas Insulin

Tus mob ntshav qab zib thiab kws kho mob teb tau zoo rau Detemir. Nws pab txhawm rau txo cov ntshav qab zib kom tsawg, muaj qhov tsawg kawg ntawm kev sib kis thiab tsis xav pom. Qhov tsuas yog ib qho yuav tau xav txog yog qhov tseeb ntawm nws cov kev tswj hwm thiab ua raws li txhua qhov kev pom zoo yog tias, sib nrug los ntawm insulin, lwm yam tshuaj tau pom zoo rau tus neeg mob.

Ntshav qab zib mellitus tam sim no tsis yog kab lus, txawm hais tias tus kab mob no tau txiav txim siab yuav luag tuag kom txog thaum tau txais cov tshuaj insulin. Los ntawm ua raws li tus kws kho mob tau pom zoo thiab soj ntsuam cov ntshav qabzib hauv cov ntshav, koj tuaj yeem tuav lub neej zoo.

Yuav ua li cas thiaj nrhiav tau qhov pheej yig tshuaj ntawm cov tshuaj kim?

Txhawm rau kom pom qhov pheej yig cov khoom sib piv rau cov tshuaj, cov dav dav lossis cov lus sau, ua ntej txhua yam, peb pom zoo kom them sai sai rau qhov muaj pes tsawg leeg, uas yog rau tib cov tshuaj nquag thiab qhia tau rau kev siv. Cov tshuaj sib xyaw zoo ib yam ntawm cov tshuaj yuav qhia tau tias cov tshuaj cuam tshuam nrog cov tshuaj, kws tshuaj sib npaug lossis chaw muag tshuaj. Txawm li cas los xij, tsis txhob hnov ​​qab txog qhov ua tsis muaj zog ntawm cov tshuaj uas zoo sib xws, uas tuaj yeem cuam tshuam kev nyab xeeb thiab ua haujlwm. Tsis txhob hnov ​​qab txog cov lus qhia los ntawm cov kws kho mob, kev noj tshuaj rau nws tus kheej tuaj yeem tsim kev puas tsuaj rau koj kev noj qab haus huv, yog li nco ntsoov sab laj rau koj tus kws kho mob ua ntej siv cov tshuaj.

Kev qhia tshuaj insulin

Pharmacological kev txiav txim:
Cov tshuaj Insulin yog qhov ua kom cov ntshav qab zib tsawg, nws muaj peev xwm tswj cov metabolism hauv kev ua kom muaj roj, ua kom cov piam thaj muaj peev xwm ntau ntxiv los ntawm cov ntaub so ntswg thiab txhawb nws txoj kev hloov pauv mus rau glycogen, thiab kuj pab txhawb kev nkag mus ntawm cov piam thaj rau cov nqaij mos.
Ntxiv rau cov nyhuv hypoglycemic (txo qis ntshav qab zib), insulin muaj ntau yam teebmeem: nws nce cov nqaij glycogen khw muag khoom noj, txhawb peptide synthesis, txo kev noj protein ntau, thiab lwm yam.
Kev tsim tawm rau cov kua dej yog tsim nrog kev tsim tawm lossis kev txwv (txwv) ntawm qee yam enzymes, glycogen synthetase, pyruvate dehydrogenase, hexokinase yog cov tshuaj tiv thaiv, lipase ua kom muaj roj fatty acids ntawm adipose nqaij, lipoprotein lipase, txo cov ntshav txhaws tom qab noj mov nplua nuj, raug tiv thaiv.
Qhov ntsuas ntawm biosynthesis thiab kev zais zais (tso pa tawm) ntawm cov kua dej yog nyob ntawm cov concentration ntawm cov piam thaj hauv cov ntshav. Nrog rau kev nce ntxiv hauv nws cov ntsiab lus, pancreatic secretion ntawm cov tshuaj insulin nce, ntawm qhov tsis tooj, qhov txo qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav ua rau cov kua dej insulin tsis pub tawm.
Hauv kev siv ntawm kev cuam tshuam los ntawm cov tshuaj insulin, lub luag haujlwm tseem ceeb yog ua si los ntawm nws kev sib cuam tshuam nrog ib qho tshwj xeeb receptor hauv zos ntawm lub plasma daim nyias nyias ntawm tes, thiab tsim muaj cov insulin receptor complex. Cov tshuaj insulin hauv kev sib xyaw nrog cov tshuaj insulin nkag mus rau hauv lub cell, qhov twg nws cuam tshuam phospholation ntawm cov xovtooj ntawm cev, cov kev tawm suab hauv lub hlwb tsis tau to taub tag nrho.
Insulin yog qhov tseem ceeb tshaj plaws rau kev kho mob ntshav qab zib mellitus, vim nws txo qis hyperglycemia (kev nce ntxiv hauv cov ntshav qab zib) thiab glycosuria (muaj cov piam thaj hauv cov zis), rov ua rau lub qog ntawm glycogen hauv lub siab thiab cov leeg, txo qhov tsim muaj cov piam thaj, thiab txo cov ntshav qab zib tsawg (muaj cov rog hauv cov ntshav) txhim kho kev mob ntawm tus neeg mob.
Cov tshuaj insulin rau kev siv kho mob yog tau los ntawm kev mob siab ntawm nyuj thiab npua. Muaj txheej txheem ntawm kev ua kom muaj zog sib xyaw ntawm cov tshuaj insulin, tab sis nws nkag tsis tau. Tsis ntev los no tsim cov txheej txheem biotechnological rau kev tsim tib neeg cov kua dej. Cov insulin tau los ntawm kev tsim hluav taws xob yog tsim los ntawm amino amino series ntawm tib neeg cov insulin.
Nyob rau hauv rooj plaub uas muaj tshuaj insulin los ntawm tus tsiaj ntawm lub cev, ntau yam tsis txaus (proinsulin, glucagon, tus kheej-statin, cov protein, polypeptides, thiab lwm yam) tuaj yeem nyob rau hauv qhov kev npaj vim muaj kev huv huv tsis txaus. Tsis zoo lim cov tshuaj tua kab mob insulin tuaj yeem ua rau muaj kev phiv tshuaj ntau.
Cov txheej txheem niaj hnub ua rau nws muaj peev xwm ua kom tau purified (monopic - chromatographically purified nrog tso tawm ntawm "lub ncov" ntawm cov kua dej), ua kom huv (monocomponent) thiab crystallized insulin npaj. Tam sim no, crystalline tib neeg cov tshuaj insulin yog nce siv. Ntawm insulin npaj ntawm tsiaj keeb kwm, kev nyiam yog muab rau cov tshuaj insulin uas tau los ntawm kab mob qog npua ntawm npua.
Insulin kev ua ub no raug txiav txim siab biologically (los ntawm kev muaj peev xwm txo cov ntshav qab zib hauv luav zoo) thiab los ntawm ib qho ntawm kev siv lub cev (electrophoresis ntawm ntawv lossis chromatography ntawm ntawv). Rau ib chav ua haujlwm (UNIT), lossis chav thoob ntiaj teb (IE), coj cov haujlwm ntawm 0.04082 mg ntawm cov kua roj insulin crystalline.

Kev taw qhia rau kev siv:
Qhov tseem ceeb qhia txog kev siv tshuaj insulin yog hom I ntshav qab zib mellitus (insulin-dependant), tab sis nyob rau qee qhov xwm txheej nws kuj tau sau tseg rau hom II mob ntshav qab zib mellitus (non-insulin-dependant).

Txoj kev siv:
Hauv kev kho mob ntshav qab zib, kev npaj tshuaj insulin ntawm ntau qhov kev txiav txim siab tau siv (saib hauv qab).
Kev siv tshuaj insulin luv luv kuj tseem siv hauv qee lwm cov txheej txheem pathological: ua rau lub xeev hypoglycemic (txo qis ntshav qab zib) hauv qee yam mob schizophrenia, raws li cov tshuaj anabolic (txhim kho protein synthesis) nrog rau kev tso pa tawm dav dav, tsis muaj zaub mov noj, furunculosis (ntau yam purulent mob ntawm daim tawv nqaij) , thyrotoxicosis (mob qog), nrog cov kab mob ntawm lub plab (atony / poob ntawm lub suab /, gastroptosis / prolapse ntawm lub plab /), mob siab ntev (mob rau daim siab ua mob), nyh ntaub ntawv ntawm daim siab mob npuas paug, raws li zoo raws li ib tug tivthaiv "polarizing" dlaws siv los kho mob coronary insufficiency (mismatch ntawm mob oxygen thov thiab nws tus me nyuam).
Kev xaiv cov tshuaj insulin rau kev kho mob ntshav qab zib yog nyob ntawm qhov mob hnyav thiab cov yam ntxwv ntawm cov chav kawm ntawm tus kab mob, qhov xwm txheej dav dav ntawm tus neeg mob, nrog rau kev ceev ntawm qhov pib thiab lub sijhawm ntawm cov nyhuv hypoglycemic ntawm cov tshuaj. Lub hom phiaj tseem ceeb ntawm insulin thiab kev tsim cov koob tshuaj yog zoo dua nqa tawm hauv tsev kho mob (tsev kho mob).
Cov tshuaj insulin luv luv yog cov kev daws teeb meem rau subcutaneous lossis intramuscular cov thawj coj. Yog tias tsim nyog, lawv kuj raug tswj hwm hauv lub cev khov kho. Lawv muaj qhov nrawm nrawm thiab luv luv cov suab thaj txo cov nyhuv. Feem ntau lawv muab tshuaj subcutaneously lossis intramuscularly 15-20 feeb ua ntej noj mov los ntawm ib qho mus rau ntau zaus thaum nruab hnub. Cov nyhuv tom qab txhaj tshuaj subcutaneous tshwm sim tom qab 15-20 feeb, nce mus txog qhov siab kawg tom qab 2 teev, tag nrho lub sijhawm ua haujlwm tsis ntau tshaj 6 teev. Lawv siv feem ntau hauv tsev kho mob los tsim cov koob tshuaj xav tau ntawm insulin rau tus neeg mob, nrog rau cov xwm txheej uas yuav tsum tau ua kom tiav sai cov kev hloov pauv hauv insulin kev ua haujlwm hauv lub cev - nrog rau cov ntshav qab zib tsis nco qab thiab precom (ua tiav lossis ib nrab ntawm qhov tsis nco qab vim tias maj mam nce siab hauv cov ntshav qab zib).
Ntxiv rau tog tog 9, kev npaj insulin luv luv yog siv los ua tus neeg sawv cev anabolic thiab raug xaj, raws li txoj cai, hauv kev txhaj tshuaj me me (4-8 units 1-2 zaug hauv ib hnub).
Kev siv tshuaj ntev (ntev ntev) insulin npaj muaj nyob rau hauv ntau cov ntawv sau nrog ntau qhov sib txawv ntawm cov suab thaj txo cov txiaj ntsig (semylong, ntev, ultralong). Rau cov tshuaj sib txawv, cov nyhuv kav ntev li 10 mus rau 36 teev. Ua tsaug rau cov tshuaj no, cov naj npawb ntawm kev txhaj tshuaj txhua hnub tuaj yeem txo. Lawv feem ntau yog tsim nyob rau hauv daim ntawv ntawm kev ncua (kev ncua ntawm cov khoom zoo ntawm cov tshuaj hauv kua), tswj tsuas yog subcutaneously lossis intramuscularly, kev tso ntshav tawm tsis pub. Hauv kev mob ntshav qab zib tsis nco qab thiab precomatous, ntev lub sij hawm cov tshuaj tsis siv.
Thaum xaiv cov tshuaj insulin, nws yog ib qho tsim nyog yuav tsum xyuas kom meej tias lub sijhawm ntawm cov txiaj ntsig qab zib kom qis tshaj plaws yuav ua rau lub sijhawm koj noj nws. Yog tias tsim nyog, 2 cov tshuaj ntawm qhov kev txiav txim siab ntev tuaj yeem muab rau hauv ib leeg. Qee tus neeg mob yuav tsum tsis ntev xwb, tab sis kuj tseem ceev ceev ntawm cov ntshav qabzib hauv cov ntshav. Lawv yuav tsum sau cov tshuaj insulin ntev thiab luv luv.
Feem ntau, cov tshuaj muaj yeeb-ntev tau siv ua ntej noj tshais, tab sis yog tias tsim nyog, kev txhaj tshuaj tuaj yeem ua tiav ntawm lwm teev.
Txhua qhov kev npaj rau insulin yog siv ua raws kev noj haus. Lub ntsiab lus ntawm lub zog nqi sau (los ntawm 1700 txog 3000 khal) yuav tsum txiav txim siab los ntawm tus neeg mob lub cev qhov hnyav thaum lub sijhawm kho, los ntawm hom haujlwm. Yog li, nrog kev noj zaub mov kom tsawg thiab ua kom lub cev muaj zog, tus naj npawb ntawm cov calories uas yuav tsum tau nyob rau ib hnub rau tus neeg mob yog tsawg kawg 3000, nrog kev noj zaub mov ntau dhau thiab kev ua neej nyob rau sedentary, nws yuav tsum tsis pub tshaj 2000.
Qhia txog kev noj tshuaj ntau dhau, nrog rau qhov tsis muaj carbohydrates nrog cov zaub mov, tuaj yeem ua rau lub xeev ntshav qab zib (txo cov ntshav qab zib), nrog rau kev xav ntawm kev tshaib plab, tsis muaj zog, tawm hws, lub cev tshee tshee, mob taub hau, kiv taub hau, mob caj dab, mob euphoria (causally zoo siab) lossis kev txhoj puab heev Cov. Tom qab, hypoglycemic coma yuav tshwm sim (tsis nco qab, tus yam ntxwv ua tiav ntawm qhov tsis txaus ntawm lub cev rau qhov kev xav sab nraud vim tias qhov txo qis hauv cov ntshav qab zib) nrog poob ntawm kev nco qab, qaug dab peg, thiab ib qho kev poob ntawm lub plawv dhia. Txhawm rau tiv thaiv lub xeev hypoglycemic, cov neeg mob yuav tsum haus dej qab zib lossis noj ob peb daim qab zib.
Nrog lub ntsej muag hypoglycemic (cuam tshuam nrog kev txo qis hauv cov ntshav qab zib), 40% kua nplaum tov rau hauv cov ntshav hauv qhov nyiaj ntawm 10-40 ml, qee zaum txog 100 ml, tab sis tsis muaj ntxiv.
Kev kho ntawm hypoglycemia (txo cov ntshav qab zib) hauv cov qauv mob tuaj yeem nqa tawm los ntawm kev siv tshuaj intramuscular lossis subcutaneous ntawm glucagon.

Phiv los sis:
Nrog kev tswj hwm ntawm subcutaneous ntawm insulin npaj, lipodystrophy (txo qis ntawm adipose nqaij hauv cov nqaij subcutaneous) yuav tshwm sim ntawm qhov chaw txhaj tshuaj.
Niaj hnub ua kom huv si insulin npaj tsis tshua muaj kev ua xua tshwm sim, txawm li cas los xij, cov rooj plaub zoo li no tsis raug cais. Kev txhim kho ntawm qhov muaj mob tsis haum yuav tsum tau ua kom sai (tiv thaiv lossis tiv thaiv kev fab tshuaj) kev hloov kho thiab hloov tshuaj.

Cov Tshuaj Tiv Thaiv:
Cov tshuaj tiv thaiv kom tsis txhob siv cov tshuaj insulin yog cov kab mob uas tshwm sim nrog hypoglycemia, mob siab, mob ntshav siab, mob qog ntshav siab (mob rau ntawm daim tawv nqaij thiab cov qog ua kua rau ntawm lub qhov muag los ntawm kev tawg ntawm cov ntshav liab), pancreatitis (mob rau lub raum), mob nephritis (mob rau lub raum) lub raum mob cuam tshuam nrog cov protein tsis txaus / amyloid metabolism), urolithiasis, mob plab thiab duodenal mob, decompensated lub plawv tsis zoo (lub plawv tsis ua haujlwm vim lub plawv tsis ua haujlwm kab mob ntawm nws li qub).
Kev ceeb toom loj yog qhov yuav tsum tau ua hauv kev kho mob rau cov neeg mob ntshav qab zib mellitus, kev txom nyem los ntawm kev tsis txaus siab rau lub plawv (kev tsis sib luag ntawm lub siab xav tau oxygen thiab nws txoj kev xa tawm) thiab lub hlwb tsis zoo | ntshav ncig. Ceev faj yog qhov tsim nyog thaum thov insulin! hauv cov neeg mob uas muaj cov thyroid, Addison's disease (tsis muaj peev xwm ua tsis txaus adrenal), lub raum tsis ua haujlwm.
Kev siv tshuaj insulin rau cev xeeb tub yuav tsum> ua tib zoo saib xyuas. Nyob rau thawj peb lub hlis thaum cev xeeb tub, qhov xav tau rau insulin feem ntau poob qis me ntsis thiab nce ntxiv hauv qib thib ob thiab thib peb.
Alpha-adrenergic blockers thiab beta-adrenostimulants, tetracyclines, salicylates nce lub zais ntawm cov endogenous (kev ua haujlwm ntawm lub cev tsim) insulin. Thiazide diupetics (diuretics), beta-blockers, cawv tuaj yeem ua rau cov ntshav qab zib tsawg.

Daim ntawv tso tawm:
Syringe insulin muaj nyob hauv iav fwj hermetically kaw nrog roj hmab stoppers nrog txhuas tawg-hauv.

Cia rau cov neeg mob:
Khaws ntawm qhov kub ntawm +2 txog + 10 * C. Tsis pub kom khov cov tshuaj txwv.

Muaj pes tsawg leeg:
1 ml ntawm kev daws lossis ncua kev kawm feem ntau muaj 40 units.
Ua raws li cov peev txheej ntawm cov khoom tsim tawm, cov kua dej insulin yog cais tawm ntawm cov tsiaj ua kua thiab ua kom sib xyaw ua ke siv cov txheej txheem engineering tsim. Raws li cov neeg kawm ntawv ntawm kev ua kom huv, kev npaj tshuaj insulin los ntawm cov tsiaj cov nqaij tau muab faib ua monopic (MP) thiab monocomponent (MK). Tam sim no tau los ntawm npua npua, lawv muaj ntxiv nrog rau tsab ntawv C (SMP - nqaij npuas monopic, SMK - nqaij npuas monocomponent), nyuj - tsab ntawv G (nqaij nyug: GMP - nqaij nyuj monopick, GMK - nqaij nyug monocomponent). Kev tiv thaiv tib neeg ntawm insulin yog qhia los ntawm tsab ntawv C.
Ua raws li lub sijhawm ua ntawm kev ua, insulins tau muab faib ua:
a) luv luv insulin npaj: pib ntawm kev nqis tes ua tom qab 15-30 feeb, qhov kawg siab kawg tom qab 1 / 2-2 teev, tag nrho lub sijhawm ua ntawm 4-6 teev,
b) insulin ua yeeb yaj kiab npaj ntev ntev muaj xws li tshuaj ntawm nruab nrab lub sijhawm (pib tom qab 1 / 2-2 teev, ncov tom qab 3-12 teev, tag nrho lub sijhawm 8-12 teev), siv yeeb tshuaj ntev (pib tom qab 4-8 teev, ncov tom qab 8-18 teev, tag nrho lub sijhawm ntawm 20-30 teev).

Pharmacological pawg:
Cov tshuaj hormones, lawv cov tshuaj tiv thaiv analogues thiab cov tshuaj tiv thaiv kabmob ntshav
Pancreatic hormone-based tshuaj thiab hluavtaws hypoglycemic
Tshuaj Insulin Pab Pawg