Cov txiaj ntsig ntawm kev siv Amikacin 1000 mg nrog cov mob prostatitis

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov hmoov dawb dawb, los ntawm qhov nws yog qhov tsim nyog los npaj cov tshuaj rau cov tshuaj intramuscular thiab intravenous.

Cov tshuaj yeeb dej caw yog amikacin sulfate, uas hauv 1 lub raj mis tuaj yeem yog 1000 mg, 500 mg lossis 250 mg. Ntu cov khoom siv kuj muaj: dej, disodium edetate, sodium hydrogen phosphate.

Pharmacological kev txiav txim

Cov tshuaj yog qhov siv dav-tshuaj tiv thaiv. Cov tshuaj muaj cov nyhuv antibacterial, rhuav tshem cov kab mob uas tiv taus cephalosporins, ua rau lawv cov cytoplasmic membranes puas. Yog tias benzylpenicillin raug kho kom txhij nrog kev txhaj tshuaj, muaj cov nyhuv synergistic rau qee cov leeg ntshav tau sau tseg. Cov tshuaj tsis cuam tshuam rau anaerobic microorganisms.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj muaj nyob rau hauv daim ntawv sau ua hmoov, los ntawm cov tshuaj tov tau npaj rau cov tshuaj intramuscular thiab leeg ntshav. Nws yog cov tshuaj qab zib-xim hygroscopic microcrystalline cov tshuaj uas muab rau hauv 10 ml ntshiab iav fwj. Txhua lub vial muaj amikacin sulfate (1000 mg). 1 lossis 5 lub fwj raug muab tso rau hauv lub thawv ntawv thawv nrog cov lus qhia.

Cov Tshuaj Pharmacokinetics

Tom qab txhaj tshuaj intramuscular, cov tshuaj yuav nqus tau 100%. Nkag mus rau hauv lwm cov ntaub so ntswg. Txog 10% khi rau cov ntshav nyob ua ke. Kev hloov hauv lub cev tsis raug. Nws raug tawm los ntawm lub raum tsis hloov txog li 3 teev. Qhov siab ntawm amikacin hauv cov ntshav ntshav yuav ntau tshaj 1.5 teev tom qab txhaj. Kev kho lub raum - 79-100 ml / min.

Cov tshuaj yeeb dej caw yog amikacin sulfate, uas hauv 1 lub raj mis tuaj yeem yog 1000 mg, 500 mg lossis 250 mg.
Amikacin muaj cov kab mob tua, ua rau cov kab mob tua tsis tau cov kab mob cephalosporins, rhuav tshem lawv cov cytoplasmic membranes.
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov hmoov dawb dawb, los ntawm qhov nws yog qhov tsim nyog los npaj cov tshuaj rau cov tshuaj intramuscular thiab intravenous.

Cov Tshuaj Hauv Tshuaj

Amikacin muaj cov kab mob bactericidal. Cov tshuaj nquag muaj cuam tshuam nrog 30S subunits ntawm ribosomes thiab tiv thaiv kev tsim ntawm matrix thiab thauj RNA ntau ceg. Cov tshuaj tua kab mob txwv tsis pub tsim cov protein ntau ntxiv uas tsim cov cytoplasm ntawm ib tus kab mob cell. Cov tshuaj no zoo tiv thaiv:

• cov kab mob tsis zoo ntawm cov kab mob aerobic (pseudomonas, Escherichia, Klebsiella, cov lus qhuab qhia, cov nqe lus, nkag mus rau cov kab mob, Salmonella, Shigella),
• Gram-positive pathogens (staphylococci, suav nrog cov kab mob tiv taus penicillin thiab 1st tiam cephalosporins).

Kuj tsis paub meej rhiab heev rau amikacin muaj:

• streptococci, nrog rau kev mob hemolytic,
• fecal enterococcus (cov tshuaj yuav tsum tau muab nrog kev sib xyaw nrog benzylpenicillin).

Cov nyhuv ntawm cov tshuaj tua kab mob tsis siv rau cov kab mob anaerobic thiab tus kab mob cab rau sab hauv. Cov tshuaj tua kab mob tsis yog pov tseg los ntawm cov enzymes uas txo cov kev ua haujlwm ntawm lwm cov aminoglycosides.

Kev qhia rau kev siv Amikacin 1000 mg

Kev qhia rau kev tswj hwm tshuaj yog:

• cov kab mob sib kis ntawm cov kab mob ntsws (mob ntsws, ua kom mob ntsws, mob txhaws ntswg, mob txhaws ntswg, mob ntsws),
• septicemia los ntawm amikacin-rhiab cov kab mob,
• cov kab mob puas tsuaj rau lub plawv lub hnab,
• cov leeg mob (cov mob rau daim npluag paj hlwb, meningoencephalitis),
• mob plab (cholecystitis, peritonitis, pelvioperitonitis),
• cov kab mob sib kis thiab mob ntawm cov mob tso zis (mob rau lub raum thiab zais zis, mob txhab ntawm qhov zis),
• purulent qhov txhab ntawm cov nqaij mos (mob viav vias, kis tus kab mob ua xua thiab herpetic eruptions, trophic mob rau ntau yam keeb kwm, pyoderma, phlegmon),
• cov txheej txheem ua mob rau lub plab hu ua pelvic (prostatitis, cervicitis, endometritis),
• cov mob sib kis hauv cov pob txha thiab pob txha mos (mob caj dab, txha nqig),
• postoperative teeb meem cuam tshuam nrog kev nkag mus ntawm cov kab mob.

Cov Khoom Muag Khoom

Cov Ntaub Ntawv Khoom Lag Luam

• Muab koob tshuaj: 1000 mg
• Daim foos tso tawm: hmoov rau kev npaj daws ntawm d / hauv / hauv thiab / m ntawm kev qhia Ua kom muaj khoom xyaw: ->
• Packing: fl.
• Chaw tsim tshuaj paus: Synthesis OJSC
• Raug tsob nroj: Synthesis (Russia)
• Cov tshuaj nquag: amikacin

Hmoov rau qhov npaj ntawm kev daws rau kev tso dej thiab tshuaj intramuscular - 1 vial:

Cov tshuaj nquag: Amikacin (hauv daim ntawv ntawm sulfate) 1 g.

Lub raj mis ntawm 1000 ml, 1 daim hauv ib pob ntawv ntawm cardboard.

Lub hmoov rau kev npaj daws ntawm cov tshuaj rau cov tshuaj dawb thiab intramuscular ntawm dawb lossis yuav luag dawb xim yog hygroscopic.

Tom qab i / m tswj hwm, nws yog nqus tau sai thiab tag nrho. Cmax hauv cov ntshav plasma nrog i / m tswj hwm ntawm koob tshuaj 7,5 mg / kg - 21 μg / ml, tom qab 30 feeb ntawm iv infusion ntawm koob tshuaj 7,5 mg / kg - 38 μg / ml. Tom qab kev txhaj tshuaj ntawm Tmax - li 1.5 teev

Qhov nruab nrab kho qhov nruab nrab kom zoo nrog iv lossis kev tswj hwm intramuscular yog tswj nyob rau 10-12 teev.

Kev khi rau cov ntshav plasma protein yog 4-11%. Vd rau cov neeg laus - 0.26 l / kg, hauv cov menyuam yaus - 0.2-0.4 l / kg, hauv cov menyuam tshiab: thaum muaj hnub nyoog qis dua 1 lub lis piam thiab hnyav dua 1500 g - txog 0.68 l / kg, thaum hnub nyoog qis dua 1 lub lis piam thiab hnyav dua 1500 g - txog 0.58 l / kg, hauv cov neeg mob cystic fibrosis - 0.3-0.39 l / kg.

Nws tau txais kev faib zoo nyob rau hauv cov kua dej ntxiv (cov ntsiab lus ntawm qog, pleural effusion, ascitic, pericardial, synovial, lymphatic thiab peritoneal kua), yog pom muaj nyob rau hauv siab ntau hauv cov zis, hauv qis - hauv cov kua tsib, kua mis, aqueous lom zem ntawm lub qhov muag, hnoos qeev, hnoos qeev thiab txha caj qaum. kua. Nws nkag mus rau hauv cov ntaub so ntswg hauv lub cev uas nws tau tsim ntau ntxiv, ntau qhov kev tso cai tau pom nyob hauv cov kabmob uas muaj ntshav txaus: mob ntsws, mob siab, myocardium, tus txha caj qaum, thiab tshwj xeeb tshaj yog nyob hauv lub raum, qhov twg nws nthuav tawm hauv cortical yam khoom, txo qis - hauv cov leeg, adipose nqaij thiab pob txha Cov.

Thaum kws kho mob hauv kev kho mob me ntsis (ib txwm) rau cov neeg laus, amikacin tsis nkag rau BBB, nrog rau kev o ntawm cov mob daim npluag qhwv, permeability nce me ntsis. Hauv cov menyuam tshiab, ntau dua nyob hauv cov kua dej ua kom tiav cerebrospinal tau tiav ntau dua li cov neeg laus. Nkag mus txog ntawm thaj chaw placental: pom nyob rau hauv cov ntshav ntawm tus me nyuam hauv plab thiab kua dej.

T1 / 2 rau cov neeg laus - 2-4 teev, hauv cov menyuam mos - 5-8 teev, nyob rau cov menyuam loj dua - 2.5-4 teev .Tus kawg T1 / 2 - ntau dua 100 teev (tso tawm los ntawm cov qhov tso rau hauv tsev).

Nws yog tawm los ntawm lub raum los ntawm glomerular pom (65-94%), feem ntau tsis hloov. Kev kho kom lub raum - 79-100 ml / min.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb.

T1 / 2 nyob rau cov neeg laus uas lub raum lub raum tsis ua haujlwm txawv nyob ntawm qhov sib txawv ntawm qhov tsis taus - txog li 100 teev, nyob rau cov neeg mob cystic fibrosis - 1-2 teev, nyob rau hauv cov neeg mob kub thiab hyperthermia, T1 / 2 tej zaum yuav luv dua li qhov nruab nrab vim yog nce ntxiv. Cov.

Nws raug nthuav tawm thaum mob hemodialysis (50% hauv 4-6 teev), peritoneal dialysis tsawg dua (25% hauv 48-72 teev).

Semi-hluavtaws broad-spectrum tshuaj tua kab mob los ntawm pab pawg ntawm aminoglycosides, ua cov kab mob bactericidal. Los ntawm kev khi rau 30S subunit ntawm ribosomes, nws tiv thaiv qhov tsim los ntawm kev thauj khoom thiab kev xa xov RNA, thaiv cov protein synthesis, thiab tseem ua rau cytoplasmic membranes ntawm cov kab mob.

Ua tau zoo los tiv thaiv aerobic gram-tsis zoo microorganisms: Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp., Qee hom kab mob kas cees: Staphylococcus. (suav nrog kev tiv thaiv ntawm penicillin, qee yam cephalosporins). Muaj txiaj ntsig tiv thaiv Streptococcus spp.

Nrog rau kev tswj hwm tib lub sijhawm nrog benzylpenicillin, nws ua kom pom cov nyhuv synergistic tiv thaiv Enterococcus faecalis leeg. Anaerobic cov kab mob me tiv taus cov tshuaj no. Amikacin tsis plam cov haujlwm hauv qhov kev nqis tes ua ntawm cov enzymes uas inactivate lwm aminoglycosides, thiab tuaj yeem ua haujlwm tiv thaiv kab mob ntawm Pseudomonas aeruginosa uas tiv taus tobramycin, gentamicin thiab netilmicin.

Cov tshuaj tiv thaiv ntawm cov tshuaj aminoglycoside.

Hauv / hauv amikacin raug tswj hwm dropwise rau 30-60 feeb, yog tias tsim nyog, los ntawm dav hlau.

Yog tias muaj teeb meem lub raum tsis ua haujlwm zoo, yuav tsum tau txhaj tshuaj ntau dua lossis ncua sij hawm nruab nrab ntawm kev tswj hwm. Nyob rau hauv qhov kev hloov ntawm lub sijhawm nruab nrab ntawm kev tswj hwm (yog tias QC tsis muaj nuj nqis, thiab tus neeg mob tus mob tseem ruaj khov), lub sijhawm nruab nrab ntawm kev tswj hwm tshuaj tau tsim los ntawm cov qauv hauv qab no:

Rau kev tswj hwm iv (kua txau), cov tshuaj tau muab tshuaj ua ntej nrog 200 ml ntawm 5% dextrose (kua nplaum) lossis 0.9% sodium chloride tov. Qhov siab ntawm amikacin hauv kev daws rau iv kev tswj hwm yuav tsum tsis pub ntau dua 5 mg / ml.

Lub luv (h) = ntshiab si creatinine concentration × 9.

Yog hais tias qhov kev sib txuam ntawm cov tshuaj creatinine yog 2 mg / dl, tom qab ntawd qhov kev pom zoo ib koob (7.5 mg / kg) yuav tsum tau siv txhua 18 teev. Nrog rau qhov nce ntxiv ntawm qhov sib nrug, qhov kev kho ib zaug tsis pauv.

Thaum lub cev txo qis hauv ib koob nrog cov koob tshuaj tas mus li, qhov tshuaj thawj rau cov neeg mob raum tsis ua haujlwm yog 7.5 mg / kg. Kev suav ntawm cov koob tshuaj tom qab yog nqa tawm raws li cov qauv hauv qab no:

Cov koob tshuaj tom qab (mg), muab txhua 12 teev = KK (ml / min) hauv tus neeg mob × thawj koob tshuaj (mg) / KK yog li qub (ml / min).

• Kab mob ua pa (mob ntsws, mob ntsws, pleural empyema, mob ntsws ntsws),
• sepsis
• mob hlab ntsha hlwb
• Cov mob CNS (suav nrog rau tus mob meningitis),
• muaj kab mob hauv lub plab (nrog rau mob rau daim tawv),
• mob txeeb zig (pyelonephritis, cystitis, mob tso zis),
• cov kab mob purulent ntawm daim tawv nqaij thiab cov nqaij mos (nrog rau qhov mob sib kis, mob sib kis thiab mob siab ntawm ntau lub hauv paus pib),
• biliary huam mob
• mob ntawm cov pob txha thiab pob qij txha (suav nrog osteomyelitis),
• qhov txhab mob
• postoperative kis tau tus mob.

• Lub paj hlwb ntawm cov leeg hlwb,
• mob raum mob raum tsis txaus siab nrog azotemia thiab uremia,
• cev xeeb tub
• muaj lub cev tsis haum rau lub tshuaj,
• hypersensitivity rau lwm cov aminoglycosides hauv keeb kwm.

Nrog kev ceev faj, cov tshuaj yuav tsum tau siv rau myasthenia gravis, parkinsonism, botulism (aminoglycosides tuaj yeem ua rau muaj kev ua txhaum ntawm cov kis mob neuromuscular, uas ua rau cov nqaij pob txha tsis muaj zog ntxiv), lub cev qhuav dej, lub raum tsis ua haujlwm, hauv lub sijhawm neonatal, hauv cov menyuam mos thaum ntxov, hauv cov neeg laus, hauv lub sijhawm kev pub mis.

Contraindicated nyob rau hauv cev xeeb tub thiab cov me nyuam qis dua 6 xyoo.

Los ntawm lub plab zom mov: xeev siab, ntuav, ua tsis tau zoo nyob hauv daim siab ua haujlwm (nce kev ua haujlwm ntawm hepatic transaminases, hyperbilirubinemia).

Los ntawm cov kab mob hemopoietic: ua haujlwm ntshav, leukopenia, granulocytopenia, thrombocytopenia.

Los ntawm sab hauv nruab nrab ntawm lub hauv nruab nrab lub paj hlwb thiab lub paj hlwb ntawm lub paj hlwb: mob taub hau, tsaug zog, cov nyhuv neurotoxic (mob leeg, loog, tingling, qaug dab peg), tsis hnov ​​qab neuromuscular kis (ua pa ntes).

Los ntawm cov kab mob hauv lub cev: ototoxicity (hnov lus tsis zoo, pob ntseg thiab pob txha loog, qhov tsis hnov ​​lus tsis zoo), muaj teeb meem rau lub cev vestibular (tsis meej pem ntawm kev txav, kiv taub hau, xeev siab, ntuav).

Los ntawm cov kab mob urinary: nephrotoxicity - lub raum khiav tsis zoo (oliguria, proteinuria, microhematuria).

Kev ua xua rau: tawv nqaij ua pob khaus, khaus, ua pob rau ntawm daim tawv nqaij, ua npaws, Quincke's edema.

Cov tshuaj tiv thaiv hauv zos: qhov mob ntawm qhov chaw txhaj tshuaj, kab mob dermatitis, phlebitis thiab mob periphlebitis (nrog rau kev tswj hwm iv).

Nws yog cov tshuaj tsis sib haum nrog penicillins, heparin, cephalosporins, capreomycin, amphotericin B, hydrochlorothiazide, erythromycin, nitrofurantoin, vitamins B thiab C, thiab potassium chloride.

Qhov siab tshaj plaws rau cov neeg laus yog 15 mg / kg / hnub, tab sis tsis ntau tshaj 1.5 g / hnub rau 10 hnub. Lub sijhawm ntawm kev kho nrog a / hauv kev taw qhia yog 3-7 hnub, nrog rau / m - 7-10 hnub.

Rau cov menyuam mos thaum yug ntxov, qhov pib ib zaug yog 10 mg / kg, tom qab ntawd 7.5 mg / kg txhua 18-24 teev, rau cov menyuam yug tshiab thiab menyuam hnub nyoog qis dua 6 xyoo, thawj koob tshuaj yog 10 mg / kg, tom qab ntawd 7.5 mg / kg txhua 12 h rau 7-10 hnub.

Txog rau kev raug mob kub hnyiab, koob tshuaj 5-7.5 mg / kg txhua 4-6 teev yuav tsum muaj vim muaj T1 / 2 luv luv (1-1.5 teev) ntawm pawg neeg mob no.

Kev siv tshuaj lom - hnov ​​pob ntseg, ataxia, kiv taub hau, tso zis tsis txaus, nqhis dej, tsis qab los, xeev siab, ntuav, lub suab nrov lossis hnov ​​zoo li hauv pob ntseg, ua pa nyuaj.

Yuav ua li cas noj Amikacin-1000

Cov tshuaj yog txhaj rau hauv lub cev nrog kev pab los ntawm kev txhaj tshuaj. Koj yuav tsum sab laj rau koj tus kws kho mob kom xaiv cov kev kho mob kom tsim nyog lossis nyeem cov lus qhia rau cov tshuaj.

Ua ntej pib siv, qhov ntsuas rhiab heev yuav tsum tau ua. Rau qhov no, tshuaj tua kab mob tau muab tshuaj nyob hauv qab daim tawv.

Rau cov menyuam yaus hnub nyoog ntau dua 1 hlis thiab cov neeg laus, 2 txoj kev xaiv tshuaj muaj peev xwm ua tau: 5 mg rau 1 kg ntawm tus neeg hnyav 3 zaug hauv ib hnub lossis 7.5 mg rau 1 kg ntawm tus neeg qhov hnyav 2 zaug hauv ib hnub. Lub chav kawm ntawm kev kho mob kav 10 hnub. Qhov tshuaj ntau ntau rau ib hnub yog 15 mg.

Nws yog txwv tsis pub siv cov tshuaj nyob rau hauv kev kho mob hauv qhov hnov ​​ntawm lub paj hlwb.
Amikacin raug txwv tsis pub muaj mob raum ntau yam.
Koj yuav tsum sab laj rau koj tus kws kho mob kom xaiv cov kev kho mob tsim nyog.
Cov tshuaj yog txhaj rau hauv lub cev nrog kev pab los ntawm kev txhaj tshuaj.
Ua ntej siv cov tshuaj, nws yog ib qho tsim nyog yuav tsum ua qhov kev ntsuas qhov ntsuas qhov muag, rau qhov no cov tshuaj tua kab mob tau tswj hwm hauv qab daim tawv nqaij.
Lub sij hawm ntawm kev kho mob nrog Amikacin kav 10 hnub.

Rau cov menyuam yug tshiab, kev kho mob yuav txawv. Ua ntej, lawv tau muab tshuaj rau 10 mg rau ib hnub, tom qab ntawd cov koob tshuaj tau raug txo rau 7,5 mg ib hnub twg. Kho cov menyuam mos tsis pub ntev tshaj 10 hnub.

Cov nyhuv ntawm cov tsos mob thiab kev pab txhawb nqa tshwm nyob rau thawj hnub lossis thib ob.

Yog tias tom qab 3-5 hnub cov tshuaj tsis ua haujlwm raws li xav tau, koj yuav tsum sab laj tus kws kho mob kom xaiv lwm yam tshuaj.

Lub plab zom mov

Tus neeg yuav hnov ​​xeev siab, ntuav, hyperbilirubinemia.

Ceev faj yuav tsum ua kom zoo thaum siv tshuaj thaum muaj hnub nyoog laus.
Kev ua xua rau cov tshuaj yog tshwm sim los ntawm daim tawv nqaij ua pob, khaus.
Nws tsis pom zoo kom tsav lub tsheb yog tias qhov tshwm sim tshwm sim: qhov no tuaj yeem tsim kev phom sij rau tus tsav tsheb thiab lwm tus.

Cov lus qhia tshwj xeeb

Qee cov neeg yuav tsum tau ua raws li txoj cai tshwj xeeb rau kev noj tshuaj.

Ib cov tshuaj tuaj yeem raug muab tshuaj rau cov menyuam yaus yog tias qhov txiaj ntsig ntawm kev kho mob tshaj qhov kev phom sij ua tau.
Cov tshuaj yog sau rau cov poj niam cev xeeb tub nkaus xwb nyob rau hauv cov xwm txheej no thaum tus poj niam lub neej nyob ntawm kev noj tshuaj.
Cov tshuaj raug txwv thaum lub sijhawm lactation.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog rau kev siv nrog rau lwm cov tshuaj, muaj kev tsis zoo tshwm sim. Nws raug nquahu kom siv cov tshuaj pleev ib ce, cov kev daws teeb meem rau cov iav lo ntsiab muag nrog ceev faj thaum kho.

Lub sijhawm siv tshuaj, nws raug nquahu kom siv cov tshuaj pleev ib ce nrog ceev faj.
Nrog kev noj tshuaj ntau dhau, tus neeg mob nqhis dej.Yog tias dhau qhov ntau ntawm cov tshuaj tau tshwm sim, lub tsheb thauj neeg mob yuav tsum raug hu.

Tej kev sib txuam uas xav tau ceev faj

Nrog cyclosporine, methoxyflurane, cephalotin, vancomycin, NSAIDs, siv nrog kev ceev faj, vim tias qhov ntxim nyiam kev txhim kho lub raum yuav ua rau ntau ntxiv. Tsis tas li ntawd, ua tib zoo ua nrog voj diuretics, cisplatin. Cov kev pheej hmoo ntawm cov kev mob tshwm sim thaum siv nrog cov neeg sawv cev hemostatic.

Cawv tau zoo

Nws yog nruj me ntsis txwv tsis pub haus dej haus cawv thaum lub sij hawm txoj kev kho.

Analogs muaj nyob nrog kev daws teeb meem. Cov neeg ua hauj lwm zoo yog Ambiotik, Lorikacin, Flexelit.

Nws yog nruj me ntsis txwv tsis pub haus dej haus cawv thaum lub sij hawm txoj kev kho.
Cov tshuaj tiv thaiv zoo ntawm cov tshuaj yog Loricacin.
Nws yog tsis yooj yim sua kom tau txais tshuaj yog tias nws tsis tau sau los ntawm kws kho mob.

Amikacin 1000 Xyuas

Diana, 35 xyoo, Kharkov: “Tus urologist tau sau tshuaj rau kev kho mob ntawm cystitis.Nws coj tib lub sijhawm lwm yam tshuaj, tshuaj ntsuab tshuaj. Nws pab cuam sai heev, Kuv pom kev daws mob los ntawm thawj hnub. Cov cuab yeej siv tau yog thiab pheej yig. "

Dmitry, 37 xyoo, Murmansk: “Kuv kho mob Amikacin nrog mob ntsws. Cov tshuaj nrawm nrawm zoo pab, txawm hais tias nws tsis zoo siab los tswj ob zaug ib hnub ib zaug. Zoo siab thiab tus nqi qis. "