Onglisa: kev tshuaj xyuas ntawm kev siv tshuaj, cov lus qhia

Onglisa yog cov tshuaj rau cov ntshav qab zib, cov tshuaj ua kom nquag plias ntawm uas yog saxagliptin. Saxagliptin yog cov tshuaj uas tau siv los kho tus mob ntshav qab zib hom 2.

Hauv 24 teev tom qab kev tswj hwm, nws inhibits qhov kev ua ntawm qhov enzyme DPP-4. Kev txwv tsis pub cov enzyme thaum sib tham nrog qabzib nce txog 2-3 zaug qib ntawm glucagon-zoo li peptide-1 (hereinafter GLP-1) thiab glucose-dependant insulinotropic polypeptide (HIP), txo qis kev ua haujlwm ntawm glucagon thiab txhawb kev teb ntawm beta hlwb.

Yog li ntawd, cov ntsiab lus ntawm insulin thiab C-peptide hauv lub cev nce. Tom qab cov tshuaj insulin raug tso tawm los ntawm beta hlwb ntawm tus txiav thiab glucagon los ntawm alpha hlwb, ceev ceev glycemia thiab postprandial glycemia yog txo qis.

Yuav ua li cas muaj kev nyab xeeb thiab siv tau ntawm saxagliptin nyob rau hauv ntau yam tshuaj tau ua tib zoo kawm hauv rau ob qhov kev tshawb fawb placebo, uas koom nrog 4148 cov neeg mob kuaj mob hom 2 mob ntshav qab zib mellitus.

Thaum lub sijhawm kev tshawb fawb, muaj kev txhim kho tseem ceeb hauv glycated hemoglobin, kev yoo plasma ntshav qab zib thiab postprandial qabzib tau sau tseg. Cov neeg mob uas tus saxagliptin monoprint tsis coj cov kev cia siab tshwm sim ntxiv rau cov tshuaj xws li metformin, glibenclamide thiab thiazolidinediones.

Cov lus pov thawj ntawm cov neeg mob thiab cov kws kho mob: 4 lub lis piam tom qab pib kho, tsuas yog saxagliptin, qib ntawm glycated hemoglobin poob qis, thiab cov ntshav plasma ceev cov ntshav tau qis dua tom qab 2 lub lis piam.

Cov ntsuas zoo tib yam tau muab sau cia hauv ib pawg ntawm cov neeg mob uas tau sau tshuaj kho sib xyaw nrog kev sib ntxiv ntawm metformin, glibenclamide thiab thiazolidinediones; analogues ua haujlwm zoo ib yam.

Hauv txhua qhov teeb meem, qhov nce hauv lub cev hnyav ntawm cov neeg mob tsis tau pom.

Thaum ua ntawv thov ongliza

Cov tshuaj yog tshuaj rau cov neeg mob uas kuaj pom tus mob ntshav qab zib hom 2 hauv qee kis:

Nrog monotherapy nrog cov tshuaj no ua ke nrog kev tawm dag zog lub cev thiab kev kho zaub mov noj,
Nrog kev kho mob sib xyaw ua ke nrog metformin,
Thaum tsis muaj kev ua haujlwm ntawm kev kho mob monotherapy nrog metformin, sulfonylurea derivatives, thiazolidinediones ua ib qho tshuaj ntxiv.

Txawm hais tias qhov tseeb tias cov tshuaj onglise tau dhau los ntawm ntau cov kev tshawb fawb thiab kev ntsuam xyuas, kev tshuaj xyuas txog nws feem ntau yog qhov zoo, kev kho tuaj yeem tsuas yog pib los ntawm kev saib xyuas ntawm tus kws kho mob.

Cov kev tsis sib haum rau kev siv ntawm onglise

Txij li thaum cov tshuaj muaj txiaj ntsig cuam tshuam rau kev ua haujlwm ntawm beta thiab alpha cells, mob siab txhawb rau lawv cov kev ua ub no, nws tsis tuaj yeem siv tas li. Cov tshuaj yog contraindicated:

Thaum cev xeeb tub, menyuam yug menyuam thiab lactation.
Cov hluas hnub nyoog qis dua 18 xyoo.
Cov neeg mob uas muaj hom 1 mob ntshav qab zib mellitus (kev ua tsis tau kawm).
Nrog cov tshuaj insulin.
Nrog cov ketoacidosis uas mob ntshav qab zib.
Cov neeg mob nrog qog ua ntshav tsis haum.
Nrog tus kheej rhiab rau ib qho ntawm cov tshuaj ntawm cov tshuaj.

Nyob rau hauv tsis muaj qee yam yuav tsum cov lus qhia rau cov tshuaj tsis tuaj yeem saib xyuas. Yog tias muaj kev ua xyem xyav txog kev nyab xeeb ntawm nws txoj kev siv, analog tshuaj tiv thaiv kab mob lossis lwm txoj kev kho yuav tsum tau xaiv.

Pom zoo kom Muab Tso Cai thiab Cov Thawj Coj

Onglisa yog muab rau noj ntawm ncauj, tsis tas yuav hais txog mov noj. Qhov nruab nrab qhov nruab nrab pom zoo hauv kev siv tshuaj txhua hnub yog 5 mg.

Yog tias kev sib xyaw ua ke yog nqa tawm, qhov tshuaj txhua hnub ntawm saxagliptin tseem tsis hloov pauv, qhov tshuaj ntawm metformin thiab sulfonylurea derivatives yog txiav txim siab cais.

Thaum pib ntawm kev sib xyaw ua ke siv cov tshuaj metformin, qhov ntau npaum ntawm cov tshuaj yuav ua raws li hauv qab no:

Onglisa - 5 mg ib hnub twg,
Metformin - 500 mg ib hnub twg.

Yog tias qhov tsis txaus ntseeg cov tshuaj tiv thaiv tau sau tseg, kev noj tshuaj ntawm metformin yuav tsum tau kho, nws yog nce ntxiv.

Yog tias, vim li cas, lub sijhawm thaum noj tshuaj ploj, tus neeg mob yuav tsum noj cov ntsiav tshuaj kom sai li sai tau. Nws tsis tsim nyog muab rau koob thib ob zaug ob zaug.

Rau cov neeg mob uas mob raum tsis zoo ua ib qho kab mob concomitant, nws tsis tas yuav kho qhov tshuaj ntawm onglise. Nrog lub raum tsis ua haujlwm ntawm cov qauv hnyav thiab mob hnyav ntawm onglis yuav tsum tau noj nyob rau hauv qhov ntau thiab tsawg dua - 2.5 mg ib hnub ib zaug.

Yog tias hemodialysis tau ua, onglisa yog coj tom qab xaus ntawm kev sib kho. Cov txiaj ntsig ntawm saxagliptin rau cov neeg mob ua mob rau peritoneal lim ntshav tseem tsis tau raug tshawb nrhiav. Yog li, ua ntej pib txoj kev kho mob nrog cov tshuaj no, kev ntsuam xyuas txaus ntawm lub raum ua haujlwm yuav tsum tau ua.

Nrog rau daim siab ua haujlwm, onglise tuaj yeem kho tau yam muaj kev nyab xeeb hauv qhov ntsuas thaj tsam nruab nrab - 5 mg ib hnub twg. Rau kev kho mob ntawm cov neeg mob laus, onglise siv nyob rau hauv tib qho. Tab sis nws yuav tsum nco ntsoov tias qhov kev pheej hmoo ntawm kev txhim kho lub raum ua tsis zoo hauv pawg no ntawm cov ntshav qab zib tau ntau dua.

Tsis muaj kev tshuaj xyuas lossis kev kawm txog kev cuam tshuam ntawm cov tshuaj rau cov neeg mob hnub nyoog qis dua 18 xyoo. Yog li, rau cov tub ntxhais hluas uas muaj ntshav qab zib hom 2, koob tshuaj tiv thaiv kab mob nrog rau lwm qhov kev ua haujlwm tau raug xaiv.

Halving qhov ntau npaum ntawm onglise yog yuav tsum yog tias cov tshuaj ib txhij kho nrog hwj chim inhibitors. Nov yog:

ketoconazole
clarithromycin,
atazanavir
indinavir
igraconazole
nelfinavir
ritonavir
saquinavir thiab telithromycin.

Yog li, qhov ntau kawg rau kev noj tshuaj txhua hnub yog 2.5 mg.

Cov yam ntxwv ntawm kev kho mob ntawm poj niam cev xeeb tub thiab cov tshwm sim

Nws tsis tau kawm txog tias cov tshuaj muaj feem cuam tshuam rau lub sijhawm cev xeeb tub, thiab seb nws puas tuaj yeem nkag mus rau niam mis, yog li ntawd, cov tshuaj tsis tau hais tseg nyob rau lub sijhawm coj tus kabmob thiab pub mis rau menyuam. Nws raug nquahu kom siv lwm yam tsiaj los siv lossis txwv kev pub mis niam.

Feem ntau, ua raws li cov tshuaj thiab cov lus pom zoo ntawm kev sib xyaw ua ke, cov tshuaj tau zoo raug zam, muaj qee yam, raws li kev txheeb xyuas pom tseeb, cov hauv qab no tuaj yeem pom:

Ntuav
Mob ncauj plab,
Mob taub Hau
Tus tsim ntawm kis kab mob ntawm lub Upper pa ib ntsuj av,
Kis kab mob ntawm cov genitourinary system.

Yog tias muaj ib lossis ntau cov tsos mob, koj yuav tsum tau ncua kev siv tshuaj lossis kho kev noj tshuaj.

Raws li kev txheeb xyuas, txawm hais tias onglise tau siv rau lub sijhawm ntev hauv kev siv tshuaj ntau dua qhov pom zoo 80 zaug, tsis muaj cov tsos mob ntawm kev lom tau sau tseg. Txhawm rau tshem tawm cov tshuaj tawm hauv lub cev thaum ua txhaum kev haus dej haus cawv, txoj kev ntsuas ntawm geomdialysis siv.

Dab tsi ntxiv uas yuav tsum paub

Onglis tsis yog kws tshuaj nrog insulin lossis hauv kev kho mob triple nrog metformin thiab thiazolididones, vim kev tshawb nrhiav ntawm lawv cov kev cuam tshuam tsis tau ua. Yog tias tus neeg mob tau mob me ntsis mus rau lub raum tsis ua haujlwm, qhov kev muab tshuaj txhua hnub yuav tsum tau ua kom tsawg. Tus neeg mob ntshav qab zib nrog lub raum tsis ua haujlwm yuav tsum tau soj ntsuam txhua lub sijhawm ntawm lub raum thaum kho mob.

Nws tau tsim tsa hais tias sulfanilurea derivatives tuaj yeem ua rau tus mob ntshav qab zib tsawg. Txhawm rau kom tsis txhob mob ntshav qab zib, qhov ntau ntawm sulfanilurea hauv kev sib xyaw nrog onglise kev kho mob yuav tsum tau kho. Ntawd yog, txo.

Yog tias tus neeg mob muaj keeb kwm kev tiv thaiv tsis haum rau lwm tus uas zoo ib yam li DPP-4 inhibitors, saxagliptin tsis yog yam tshuaj. Raws li kev nyab xeeb thiab muaj txiaj ntsig ntawm kev kho mob ntawm cov neeg laus laus (tshaj li 6 xyoo) nrog cov tshuaj no, tsis muaj lus ceeb toom hauv qhov no. Onglisa muaj kev thev taus thiab ua rau nws xav tau ib yam li nyob hauv cov neeg hluas.

Txij li cov khoom lag luam muaj cov lactose, nws tsis haum rau cov neeg uas muaj kev tsis txaus siab rau cov khoom no, lactose tsis txaus, qabzib-galactose malabsorption.

Cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav tsheb thiab lwm yam cuab yeej siv uas yuav tsum muaj kev kub siab ntawm kev saib xyuas tsis tau kawm tag nrho.

Tsis muaj kev cuam tshuam ncaj qha rau kev tsav tsheb, tab sis nws yuav tsum nco ntsoov tias ntawm cov kev mob tshwm sim ntawm kiv taub hau thiab mob taub hau tau sau tseg.

Kev cuam tshuam nrog lwm yam tshuaj

Raws li kev tshawb fawb hauv chav kho mob, kev pheej hmoo ntawm kev sib cuam tshuam ntawm onglises thiab lwm yam tshuaj, yog tias noj ib txhij, nws yog tsawg heev.

Cov kws tshawb fawb tsis tau tsim kom meej li cas kev haus luam yeeb, kev haus dej haus cawv, kev siv cov tshuaj homeopathic, lossis zaub mov noj kom lub cev muaj kev cuam tshuam rau cov tshuaj, vim tsis muaj kev tshawb fawb hauv thaj chaw no.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv sau cov tshuaj Onglis yog cov ua yeeb yaj kiab-ua yeeb yaj kiab: puag ncig, biconvex, cov ntawv sau tau sau nrog cov xim xiav, 2.5 mg txhua - los ntawm lub teeb mus rau daj daj daj, lub inscription “2.5” ntawm ib sab, thiab ““ 4214 ", 5 mg txhua - paj yeeb, rau ib sab ntawm cov ntawv sau" 5 ", nyob rau lwm qhov -" 4215 "(10 pcs. Hauv cov hlwv, hauv daim duab los qhia 3 lub ntsej muag).

Composition 1 ntsiav tshuaj:

cov tshuaj nquag: saxagliptin (hauv daim ntawv ntawm saxagliptin hydrochloride) - 2.5 lossis 5 mg,
Cov khoom siv pabcuam: lactose monohydrate - 99 mg, microcrystalline cellulose - 90 mg, croscarmellose sodium - 10 mg, magnesium stearate - 1 mg, 1M daws ntawm hydrochloric acid - hauv qhov ntau ntau,
plhaub: Opadry II dawb (polyvinyl cawv - 40%, titanium dioxide - 25%, macrogol - 20,2%, talc - 14.8%) - 26 mg, Opadry II daj (rau ntsiav tshuaj 2.5 mg) polyvinyl cawv - 40%, titanium dioxide - 24.25%, macrogol - 20.2%, talc - 14.8%, zas xim hlau oxide daj (E172) - 0.75% - 7 mg, Opadry II liab dawb (rau 5 mg ntsiav tshuaj) polyvinyl cawv - 40%, titanium dioxide - 24.25%, macrogol - 20.2%, talc - 14,8%, zas xim hlau oxide liab (E172) - 0.75% - 7 mg,
mem kua: Opacode xiav - (45% shellac hauv ethyl cawv - 55.4%, FD&C xiav # 2 / indigo carmine txhuas xim - 16%, n-butyl cawv - 15%, propylene glycol - 10.5%, isopropyl cawv - 3% , 28% ammonium hydroxide - 0.1%) - hauv qhov ntau txaus.

Cov Tshuaj Hauv Tshuaj

Saxagliptin yog qhov muaj zog xaiv tau kev thim rov qab sib tw dipeptidyl peptidase-4 (DPP-4) inhibitor. Ntawm hom 2 mob ntshav qab zib mellitus, nws txoj kev tswj hwm ua rau kev tsuj ntawm kev ua si ntawm DPP-4 enzyme rau 24 teev. Tom qab noj cov piam thaj, inhibition of DPP-4 ua rau muaj 2-3 zaug kev nce siab nyob rau hauv kev ua kom tau ntawm cov piam thaj-insulinotropic polypeptide (HIP) thiab glucagon-zoo li peptide-1 (GLP-1), qhov nce ntawm glucose-based beta cell teb thiab qhov txo qis hauv glucagon concentration, uas ua rau muaj kev nce siab ntxiv hauv glucagon concentration. C peptide thiab cov tshuaj insulin.

Txo kev tso tawm ntawm glucagon los ntawm pancreatic alpha cells thiab kev tso tawm ntawm insulin los ntawm pancreatic beta hlwb ua rau txo qis sai ntawm kev ua haujlwm postprandial glycemia thiab glycemia.

Raws li kev soj ntsuam cov tshuaj placebo, nws tau pom tias noj Onglisa tau nrog ib txoj kev zoo txhim kho hauv kev yoo ntshav qabzib (GPN), glycosylated hemoglobin (HbA)_1c) thiab ntshav qab zib tom qab (BCP) ntshav ntshav hauv kev sib piv nrog kev tswj hwm.

Cov neeg mob uas tsis tau ua tiav lub hom phiaj glycemic thaum noj saxagliptin li monotherapy tseem ntxiv cov tshuaj metformin, thiazolidinediones lossis glibenclamide. Thaum noj 5 mg ntawm saxagliptin, txo qis HbA_1c sau tseg tom qab 4 lub lim tiam, GPN - tom qab 2 lub lis piam. Hauv cov neeg mob uas tau txais saxagliptin txuam nrog metformin, thiazolidinediones lossis glibenclamide, qhov zoo sib xws tau pom.

Tawm tsam cov keeb kwm yav dhau los ntawm kev noj Onglisa, qhov nce hauv lub cev hnyav tsis tau sau tseg. Cov nyhuv ntawm saxagliptin ntawm cov lipid profile zoo ib yam li cov placebo.

Cov Tshuaj Pharmacokinetics

Hauv cov neeg tuaj yeem noj qab haus huv thiab nyob hauv cov neeg mob uas muaj ntshav qab zib hom 2, zoo ib yam li pharmacokinetics ntawm saxagliptin thiab nws cov metabolite tseem ceeb.

Cov tshuaj tom qab qhov ncauj coj ntawm lub plab khoob sai sai. Txawj C_max (qhov siab tshaj plaws ntawm ib yam khoom) ntawm saxagliptin thiab lub ntsiab metabolite hauv plasma tshwm sim dhau 2 teev thiab 4 teev, feem. Nrog kom qhov ntau ntxiv koob tshuaj, nce ntxiv ntawm C_max thiab AUC (thaj chaw hauv qab qhov tsom-lub sijhawm nkhaus) ntawm ob yam khoom thiab nws lub cev khoom noj tseem ceeb. Tom qab txhaj ib koob tshuaj 5 mg ntawm saxagliptin los ntawm cov neeg tuaj yeem noj qab haus huv, cov nqi nruab nrab ntawm C_max saxagliptin thiab nws cov metabolite tseem ceeb hauv plasma yog 24 ng / ml thiab 47 ng / ml, AUC qhov tseem ceeb yog 78 ng × h / ml thiab 214 ng × h / ml, feem.

Qhov nruab nrab ntawm lub sijhawm kawg T kawg_1/2 (ib nrab-lub neej) ntawm saxagliptin thiab nws cov metabolite tseem ceeb yog 2.5 teev thiab 3.1 teev, raws li, tus nqi nruab nrab ntawm qhov inhibition T_1/2 Plasma DPP-4 - 26.9 teev. Kev txwv tsis pub plasma DPP-4 kev ua haujlwm tsawg kawg 24 teev tom qab noj saxagliptin cuam tshuam nrog nws muaj kev sib raug zoo rau DPP-4 thiab lub caij nyoog khi rau nws. Pom tau lub zog ruaj khov ntawm cov tshuaj thiab nws cov metabolite thaum lub sij hawm kawm ntev nrog kev tswj hwm ntawm 1 zaug hauv ib hnub yog tsis pom. Qhov tos ntawm qhov kev tshem tawm ntawm saxagliptin thiab nws cov metabolite tseem ceeb ntawm kev noj tshuaj txhua hnub thiab lub sijhawm ntawm kev kho mob thaum noj cov tshuaj 1 zaug hauv ib hnub nyob rau ntau npaum li cas ntawm 2.5-400 mg rau 14 hnub tsis tau kuaj pom.

Tom qab lub qhov ncauj tswj hwm, tsis pub tsawg dua 75% ntawm qhov koob tshuaj noj yog nqus tau. Noj ntawm pharmacokinetics ntawm saxagliptin tsis cuam tshuam loj heev. Cov zaub mov muaj rog heev cuam tshuam C_max tsis muaj tshuaj, tab sis AUC qhov tseem ceeb hauv kev sib piv nrog yoo nce los ntawm 27%. Thaum noj cov tshuaj nrog cov zaub mov, piv nrog yoo mov, lub sijhawm kom ncav C nce txog li 30 feeb_maxCov. Cov kev pauv hloov no tsis muaj qhov tseem ceeb rau lub chaw kuaj mob.

Saxagliptin thiab nws lub ntsiab metabolite khi rau cov ntshiab cov protein ntau. Hauv qhov no, nws tuaj yeem xav tias nrog kev hloov pauv ntawm cov protein sib xyaw cov ntshav ntshiab pom hauv lub raum lossis hepatic tsis txaus, kev faib tawm saxagliptin yuav tsis muaj kev hloov pauv tseem ceeb.

Cov tshuaj yog metabolized feem ntau nrog kev koom tes ntawm cytochrome P450 3A4 / 5 isoenzymes (CYP 3A4 / 5). Hauv qhov no, lub zog tseem ceeb ntawm cov khoom siv metabolite yog tsim, cov nyhuv inhibitory uas tiv thaiv DPP-4 yog 2 lub sijhawm tsis muaj zog dua li ntawm saxagliptin.

Saxagliptin nrog cov kua tsib thiab tso zis tawm sab nraud. Qhov nruab nrab lub raum kev tshem tawm cov tshuaj yog kwv yees li 230 ml / min, qhov nruab nrab ntawm lub qog glomerular yog li 120 ml / min. Cov hlwv tawm tshem tawm rau cov metabolite tseem ceeb yog sib piv nrog cov txiaj ntsig nruab nrab ntawm glomerular pom.

AUC tus nqi ntawm saxagliptin thiab nws lub ntsiab metabolite nrog lub raum tsis ua haujlwm yog 1.2 thiab 1.7 npaug siab dua, feem, ntau dua li cov neeg mob uas lub raum tsis ua haujlwm. Qhov nce no ntawm AUC qhov tseem ceeb tsis yog qhov tseem ceeb hauv kev kuaj mob, thiab kev hloov kho tshuaj yuav tsum tsis txhob ua.

Hauv kev nruab nrab / lub raum tsis ua haujlwm, nrog rau cov neeg mob hemodialysis, AUC qhov tseem ceeb ntawm cov tshuaj thiab nws cov metabolite tseem ceeb yog 2.1 thiab 4.5 npaug siab dua, feem. Hauv qhov no, koob tshuaj rau txhua hnub rau pawg neeg mob no yuav tsum tsis pub tshaj 2.5 mg hauv 1 koob tshuaj. Thaum muaj teeb meem rau daim siab tsis haum, kev saib xyuas kev hloov pauv hauv lub chaw muag tshuaj ntawm saxagliptin tseem tsis tau pom thiab, raws li, kev hloov kho koob tshuaj yog tsis tsim nyog.

Clinically tseem ceeb sib txawv hauv pharmacokinetics ntawm saxagliptin hauv cov neeg mob 65-80 xyoo uas piv nrog cov neeg mob hnub nyoog yau tsis tau txheeb xyuas. Txawm hais tias qhov tseeb tias tsis tas yuav txhaj koob tshuaj rau pawg neeg mob no, nws yog ib qho tsim nyog yuav tsum tau coj mus rau hauv qhov kev pheej hmoo siab ntawm qhov txo qis hauv lub raum kev ua haujlwm.

Kev ntsuas rau siv

Onglisa yog qhov tsim nyog rau kev kho mob hom 2 mob ntshav qab zib mellitus raws li kev txhais tau ntxiv rau kev tawm dag zog thiab kev noj haus kom thiaj li txhim kho glycemic tswj.

Cov tshuaj tuaj yeem tsim tawm raws li hauv qab no:

tshuaj mob hlwb
pib txoj kev kho ua ke nrog metformin,
ntxiv rau kev kho mob monotherapy nrog thiazolidinediones, metformin, sulfonylurea derivatives thaum tsis muaj glycemic txaus tswj thaum lub sijhawm kho mob ntawd.

Cov lus qhia rau kev siv Onglises: hom thiab ntau npaum li cas

Onglisa noj ntawm qhov ncauj, tsis hais txog ntawm kev ua zaub mov.

Cov koob tshuaj pom zoo yog 5 mg hauv 1 koob tshuaj.

Thaum ua kev kho ua ke, Onglisa yog siv nrog metformin, sulfonylureas lossis thiazolidinediones.

Thaum pib sib xyaw nrog kev siv tshuaj nrog metformin, nws cov koob tshuaj txhua hnub yog 500 mg. Thaum tsis teb rov qab, yuav muaj ntau zog.

Yog tias ib koob tshuaj Onglisa tau ploj lawm, nws yuav tsum ua kom sai li sai tau, txawm li cas los xij, ob koob tshuaj yuav tsum tsis txhob noj nyob hauv 24 teev.

Cov koob tshuaj txhua hnub rau cov neeg mob uas muaj qhov tsis txaus / lub raum tsis ua haujlwm (nrog creatinine tshem tawm ≤ 50 ml / min), ntxiv rau cov neeg mob ntawm hemodialysis, yog 2.5 mg hauv 1 koob tshuaj. Ongliz yuav tsum tau noj tom qab qhov kawg ntawm qhov kev hloov kho hemodialysis. Kev siv cov tshuaj nyob rau hauv cov neeg mob ntawm peritoneal lim ntshav tsis tau kawm. Ua ntej pib / thaum siv tshuaj kho mob, nws raug nquahu kom soj ntsuam lub raum kev ua haujlwm.

Cov tshuaj pom zoo txhua hnub ntawm Onglisa thaum ua ke nrog indinavir, nefazodone, ketoconazole, atazanavir, ritonavir, clarithromycin, itraconazole, nelfinavir, saquinavir, telithromycin thiab lwm yam muaj zog CYP 3A4 / 5 inhibitors yog 2.5 mg.