Trometamol (trometamol)

Cov mis C4H11NO3, tshuaj lub npe: 2-amino-2- (hydroxymethyl) -1,3-propanediol.
Pharmacological pawg: metabolites / cov tswj ntawm dej-electrolyte tshuav nyiaj li cas thiab acid-puag lub xeev.
Pharmacological kev txiav txim: diuretic, rov qab muaj roj alkaline lub xeev cov ntshav.

Cov chaw muag tshuaj

Trometamol muaj cov khoom buffering. Tromethamol thaum muab cov tshuaj ua kom cov kua dej muaj roj ntau ntxiv thiab txo cov ntsiab lus ntawm hydrogen ions, thiaj li tshem tawm cov kua qaub. Trometamol nkag mus rau hauv cov xoos ntawm tes, pab tshem tawm cov tshuaj tiv thaiv acidosis, muaj cov nyhuv osmotic diuretic thiab hypoglycemic. Trometamol yog tus lees txais. Trometamol tsis nce ntxiv qhov kev kub siab ntawm carbon dioxide nyob rau hauv cov ntshav, tsis zoo li sodium bicarbonate. Trometamol tuaj yeem siv rau kev ua pa thiab ua pa acidosis. Trometamol stimulates diuresis thiab tawm tag nrho los ntawm lub raum tsis hloov, tom qab 8 teev 75% ntawm cov tshuaj tawm hauv lub cev tawm. Alkalization ntawm cov zis thiab osmodiuretic kev ua haujlwm ua rau muaj kev tshem tawm cov kua qaub uas tsis muaj zog los ntawm lub cev. Trometamol undergoes glomerular filtration thiab tsis yauv mus rau tubular resorption, yog li nws, zoo li osmotic diuretics, nce diuresis thiab, nrog khaws cia glomerular pom, yog tawm raws sai sai. Qhov no ua rau lub raum muaj nuj nqi tej zaum yuav xav tau nyob rau hauv oliguria thiab metabolic acidosis. Tom qab lub qhov ncauj tswj hwm, nws tsis yog nqus, ua raws li cov dej qab ntsev.

Cov kab mob uas nrog cov mob metabolic thiab sib xyaw ua ke acidosis (hloov ntshav ntau, ua rau poob siab, muaj kev tawm tsam ntxiv, kab mob peritonitis, hlawv kub hnyiab, mob leeg qhuav), mob ntshav qab zib ketoacidosis, thaum rov kho dua thiab nyob rau lub sijhawm rov ua haujlwm sai sai rau kev tshem tawm acidosis, lom nrog barbiturates, salicylates, salicylates, cawv, rau kev tiv thaiv acidosis hauv kev teem caij ntawm allopurinol.

Muab cov tshuaj trometamol thiab koob tshuaj

Trometamol raug tso tshuaj rau ntawm tus nqi ntawm 120 tee hauv ib feeb, qhov nce ntxiv ntawm kev tswj hwm tsis pom zoo rau kev tiv thaiv cov kev phiv tshuaj (kev tswj hwm ceev yog tau tshwj xeeb tshwj xeeb (piv txwv, kom tshem tawm acidosis thaum lub plawv nres)). Cov koob tshuaj ntawm trometamol tau teeb tsa ib leeg zuj zus raws li cov ntawv tshuaj uas tau siv, tus neeg mob lub cev qhov hnyav, thiab lub hauv paus tsis txaus. Qhov siab tshaj plaws tau txhaj tshuaj yog 1.5 g / kg ib hnub. Kev rov ua dua ntawm cov tshuaj trometamol yog tau tom qab 2 txog 3 hnub.
Lub cev ntawm trometamol rau hauv qhov chaw tuag tau tuaj yeem ua rau kev loj hlob ntawm cov nqaij hauv lub cev necrosis.
Thaum kho, muaj kev pheej hmoo ntawm kev mob ntsws.
Hauv cov menyuam mos yug tshiab, kev siv cov tshuaj muaj peev xwm ua tau tsuas yog thaum qhov kev cia siab uas tau txais txiaj ntsig ntawm kev kho mob tshaj qhov muaj kev pheej hmoo.
Thaum kho, nws yog ib qho tsim nyog los tswj lub siab ntawm cov piam thaj, bicarbonate thiab lwm cov ntshav electrolytes, acid-puag lub xeev, ntshav ionogram, qee qhov siab ntawm cov pa roj carbon dioxide, ua cov diuresis yuam.

Phiv cuam tshuam los ntawm trometamol

Cov tshuaj tiv thaiv hauv zos: phlebitis, venous spasm, voos ntawm phab ntsa ntawm cov leeg, hemolysis, thrombophlebitis, necrosis hauv zos.
Kev ntshaib plab metabolic: Kev ua haujlwm hypokalemia, hyponatremia, hypochloremia, mob ntshav qab zib.
Lwm yam: hypotension, ua tsis taus pa, ua pa nyuaj siab, lub plawv ua pa hauv lub siab, tsis txaus siab (suav nrog xeev ntuav, ntuav), kev ua kom tsis muaj zog.

Kev sib cuam tshuam ntawm trometamol nrog lwm yam tshuaj

Trometamol tsis muaj zog cov nyhuv ntawm barbiturates, indirect anticoagulants (coumarin derivatives), salicylates.
Trometamol txhim kho cov nyhuv ntawm tricyclic antidepressants, narcotic analgesics, chloramphenicol, macrolides (oleandomycin, erythromycin), aminoglycosides.
Nrog kev siv ua ke ntawm trometamol thiab tshuaj tiv thaiv kab mob, cov nyhuv tshuaj tiv thaiv hypoglycemic tuaj yeem ua rau ob leeg (nrog rau kev txhim kho hypoglycemia), yog li nws yuav tsum zam kom tsis txhob sib koom siv lossis txo qhov tshuaj ntawm cov tshuaj antidiabetic.

Noj ntau dhau

Nrog kev noj tshuaj ntau dhau ntawm trometamol, cov kev mob tshwm sim nce ntxiv (feem ntau tsis muaj zog, hypotension, ua pa tsis tu ncua, ua pa nyuaj, xeev siab, hypoglycemia, ntuav, tsis hnov ​​qab acid-puag tshuav thiab dej-electrolyte tshuav). Kev kho mob yooj yim yog tsim nyog, yog tias tsim nyog, siv tshuab ua pa tawm. Tsis muaj ib qho tshuaj tua kab mob tshwj xeeb.

Kws Tshuaj

Nrog rau kev tswj hwm iv, nws txo qis kev ua kom tiav ntawm hydrogen ions thiab nce lub siab cawv ntawm cov ntshav, thiaj li tshem tawm cov acididemia, nkag mus rau hauv lub hlwb rau hauv daim nyias nyias thiab pab tshem tawm cov tshuaj tiv thaiv acidosis, yog tawm tag nrho los ntawm lub raum tsis hloov thiab ua rau lub zog diuresis. Thaum muab tshuaj, nws ua haujlwm li saline laxative.

Tso cov ntaub ntawv thiab cov nyob ua ke

Qhov muab daim ntawv tshuaj ntawm cov tshuaj yog txoj kev daws teeb meem. Nyob rau hauv tsos nws yog ntshiab, tsis muaj kua uas tsis muaj lwm qhov txawv txav. Tseem tsis muaj ntxhiab tsw ntxhiab. Cov pes tsawg leeg hauv daim ntawv tsuas tshuaj suav nrog kev ua haujlwm thiab ntxiv cov ntsiab lus. Ntu Cheebtsam ua haujlwm li stabilizers, khaws cia txhua tus physicochemical cov yam ntxwv ntawm cov tshuaj nquag.

Rau 1 liter ntawm daim ntawv tshuaj ntau npaum li cas:

• tsis ntau tshaj 36.5 g ntawm tromethamol fosfomycin,
• 0.37 g ntawm poov tshuaj tshuaj dawb,
• tsis ntau tshaj 1.75 g ntawm sodium hydrochloride.

Cov kev hais los saum toj no yog qhov pib. Cov muaj mob:

• acetic acid (tsis ntau tshaj 99%),
• lim dej.

Daim ntawv tsuas tshuaj yog nchuav rau hauv lub khob (1 l) ntawm cov iav pob tshab. Sab saum toj ntawm lub raj mis yog hermetically kaw nrog roj hmab nres thiab ntawv ci liab.

Acid-puag nyiaj tshuav thiab alkalization | Yuav ua li cas alkalize lub cev

Yuav ua li cas sai sai kom paub txog qib kev txhaum cai ntawm pH nyob hauv tsev?

Kev ntsuam xyuas yooj yim rau kev txiav txim siab acid-lub hauv paus sib npaug siv kev siv pa

Pharmacological kev txiav txim

Ib qho tshuaj noj nrog rau hauv kev siv tshuaj kho mob evens tawm cov alkaline sib npaug los ntawm kev txo qis hydrogen ions. Cov tshuaj nquag, uas yog ib feem ntawm cov tshuaj, yog proton acceptor. Thaum sodium ions nkag mus rau hauv lub cev, hydrocarbonate rov ua kom rov zoo li qub, uas ua rau kom muaj qhov siab ntawm cov pa roj carbon dioxide thaum lub caij ua pa acidosis.

Acid-lub hauv paus muaj nyiaj yog tsim vim muaj peev xwm ntawm cov tshuaj kom sib npaug acidity thiab pH.

Hauv qhov no, cov khoom ntawm oxidation ntawm acids ntawm cov organic keeb kwm tawm hauv lub cev sai dua.

Cov Tshuaj Pharmacokinetics

Nrog Txoj kev lis ntshav, cov tshuaj nkag ncaj qha rau hauv cov hlab ntshav, uas nqa nws los ntawm cov ntaub so ntswg mos. Kev kho mob siab tshaj plaws tau tiav tom qab 1.5-2 teev tom qab kev tso dej khov. Cov tshuaj tawm hauv lub cev tsis hloov nrog cov zis. Yog hais tias tus neeg mob muaj teeb meem nrog lub cev tawm ntawm cov zis, nws raug nquahu kom thim tawm cov tshuaj los ntawm cov tshuaj yuam kev diuresis. Qhov kev tshem tawm ib nrab-lub neej yuav siv 6-8 teev.

Kev ntsuas rau siv

Cov cim tseem ceeb rau kev siv yog ua pa thiab metabolic acidosis. Raws li cov lus qhia, kev kho tshuaj yeeb muaj peev xwm ua tau nrog pathologies xws li:

• hlawv ntawm qib 3-4,
• tomqab mob acidosis tas,
• hloov ntshav acidosis,
• lom nrog salicylates, methyl cawv thiab barbiturates,
• cell acidosis, uas tsim nyob rau tom qab ntawm hypoglycemia,
• poob siab lub xeev
• cerebral edema,
• lom pulmonary edema,
• lub raum tsis ua haujlwm tom qab phais.

Qhov no yog cov tshuaj ntawm ntau cov teebmeem, uas yog siv hauv orthopedics, neurology, phais pob txha, kev kho mob qog nqaij hlav hauv menyuam yaus thiab cov neeg laus, suav nrog kev phais mob los khaws cov khoom hauv nrog cev hauv oncology. Ntxiv nrog rau kev kho kom rov qab tso kua qaub-lub hauv paus kev tshuav nyiaj li cas, cov tshuaj ua rau lub zog CBS.

Cov Yuav Tsum Muaj

Nrog meej contraindications sau tseg nyob rau hauv annotation, kev siv cov tshuaj yog qhov tsis tuaj yeem. Cov no suav nrog:

• cov menyuam yaus hnub nyoog (txog 12 hlis),
• kev tiv thaiv tsis haum
• cawv,
• poob siab (theem cua sov),
• emphysema
• hypokalemia
• ua haujlwm dhau
• tshuaj mob siab ntsws.

Yog tias tus neeg mob lub raum tsis ua haujlwm loj, kev siv yog nruj heev.

Yuav noj li cas trometamol

Daim ntawv ntau npaum no yuav tau noj nrog dej ntev li 60 feeb. Yog tias vim li cas kev noj qab haus huv muaj qhov xav tau rau txoj kev tswj hwm dua, tom qab ntawd cov koob tshuaj yuav tsum raug txo. Kev siv tshuaj kho yog txiav txim siab ntawm tus kheej, nyob ntawm seb qhov hnyav ntawm tus kab mob.

Kev muab tshuaj yog suav raws tus neeg mob lub cev qhov hnyav. Qhov pom zoo ntawm kev kho tshuaj rau txhua hnub yuav tsum tsis txhob ntau dua 36 g / kg ntawm qhov hnyav, uas yog sib npaug rau 1000 ml. Cov kev cai niaj hnub rau cov menyuam yaus hnub nyoog qis dua 12 xyoos yuav tsum tsis pub tshaj 20-30 ml.

Nrog ntshav qab zib

Qhov siab tshaj niaj hnub noj rau cov neeg mob ntshav qab zib yuav tsum tsis pub tshaj 10-15 g ib 10 kg ntawm qhov hnyav. Ib koob tshuaj siab xav tau qhov sib ntxiv ntawm sodium chloride. Nrog rau kev pheej hmoo ntawm kev txhim kho hypoglycemic coma, insulin thiab dextrose hauv txoj kev hais daws yuav tsum tau muab ib txhij nrog cov tshuaj.

Phiv cuam tshuam los ntawm trometamol

Feem ntau, cov tshuaj tau zoo txaus los ntawm tus neeg mob. Cov kev mob tshwm sim los tiv thaiv keeb kwm ntawm ib qho xaiv tsis raug ntawm cov tswj hwm tshuaj:

• voos ntawm phab ntsa ntawm cov hlab ntsha
• siab surges
• venospasm
• thrombophlebitis ntawm qhov chaw txhaj tshuaj,
• Ib nrab siab txo
• nce hauv pH
• neeg siab phem,
• tshuaj mob siab ntsws.

Hauv raum tsis ua haujlwm, poov tshuaj yog yuam tawm ntawm cov hlwb sai dua.

Cuam tshuam rau lub peev xwm los tswj cov tshuab

Kev siv cov tshuaj thaum lub sijhawm rov ua kom zoo dua tom qab kev phais mob thiab kev phais me me tuaj yeem cuam tshuam kev ceev ntawm psychomotor cov tshuaj tiv thaiv. Nws tsis pom zoo kom tsav tsheb thaum lub sijhawm siv tshuaj.

Cov lus qhia tshwj xeeb

Cov tshuaj yuav tsum tsis txhob poob rau hauv qhov chaw paravenous. Hauv qhov no, qhov kev pheej hmoo ntawm kev tsim cov nqaij mos necrosis nce. Yog tias siv tsis raug, tus neeg mob yuav muaj kev nyuaj siab ua pa nyuaj. Saib xyuas cov ntshav qabzib ntau yog yuav tsum tau ua, cov ntshiab ionograms yuav tsum tau ua qhov tsis tu ncua. Thaum kho, cov concentration ntawm bicarbonate yuav nce ntxiv.

Yog tias tus neeg mob tau kho mob diuretic, nws yog qhov yuav tsum tau coj tus cwj pwm tso zis.

Cov lus qhia sai sai ntawm cov tshuaj ua rau muaj kev pheej hmoo ntawm pathologies los ntawm cov kab mob hematopoietic.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv tshuaj ib zaug rau kev siv tshuaj thiab tshuaj tiv thaiv kab mob siab tuaj yeem txo kev phom sij ntawm hypoglycemia. Nws tsis pom zoo kom sib tov cov tshuaj hauv ib lub thawv nrog lwm cov tshuaj. Rau kev sib xyaw kom sib xyaw, nws yog qhov yuav tsum tau them sai sai rau cov xim ntawm qhov kev daws teeb meem: yog tias cov kua tau los ua huab lossis nag lossis daus tshwm, nws yog txwv tsis pub nkag mus rau tus neeg mob.

Cov tshuaj muaj peev xwm txhim kho kev ua haujlwm ntawm ntau cov tshuaj, suav nrog narcotic analgesics, aminoglycosides, tshuaj tua kab mob (Biseptrim, Monural), chloramphenicol, NSAIDs (Dexketoprofen), tricyclic antidepressants.

Txoj hauv kev daws teeb meem ua ke nrog kev tiv thaiv tsis ncaj rau tus kheej (coumarin derivatives) salicylates thiab barbiturates tuaj yeem txo qhov kev ua si ntawm tom kawg.

Cawv tau zoo

Cov tshuaj yeeb dej caw hauv cov txheej txheem ntau npaum li cas tuaj yeem txhim kho qhov kev ua haujlwm ntawm ethanol, yog li ua rau pom kev txhim kho ntawm qhov muaj zog intoxication hauv lub cev. Nyob rau lub sijhawm siv, nws raug nquahu kom tsis pub haus dej haus cawv.

Cov tshuaj muaj 1 tus qauv analogue thiab ob peb lub generics. Txhua yam hloov pauv muaj qhov kho kom zoo sib xws rau qhov qub thiab yuav sib txawv hauv muaj pes tsawg leeg. Cov tshuaj zoo heev ntawm cov tshuaj:

Tus qauv analogues thiab cov generics muaj contraindications, nyob ib puag ncig uas siv yuav tsis yooj yim sua.

Kuv tuaj yeem yuav yam tsis tas yuav tshuaj

Hauv qee lub khw muag tshuaj online, koj tuaj yeem yuav cov tshuaj yam tsis muaj daim ntawv yuav tshuaj. Hauv qhov no, nws yuav tsum nco ntsoov tias qhov qub ntawm cov tshuaj yuav hauv Is Taws Nem tsis tau lees paub los ntawm dab tsi.

Kev ceev faj txog cov tshuaj trometamol

Kev soj ntsuam ntawm cov ntsiab lus ntawm cov piam thaj thiab electrolytes ntawm cov ntshav, KShchS yog lub luag haujlwm.

Trometamol N - ib yam tshuaj uas tsim los kho tus mob acidosis. Tus neeg sawv cev yog siv tus yam ntxwv ntawm txoj kev so, uas yog, tswj hwm kom ncaj khov. Kuv yuav txheeb xyuas rau cov nyeem ntawm "Nrov txog Kev Noj Qab Haus Huv" cov lus qhia rau cov khoom lag luam no.

Yog li, kev qhia ntawm trometamol N:

Dab tsi yog trometamol N muaj pes tsawg leeg thiab daim ntawv ntawm kev tso tawm ?

Cov tshuaj Trometamol N muaj nyob rau hauv cov tshuaj tov rau infusion, cov kua yog tsis muaj xim, tsis muaj ntxhiab, yuav tsum tsis muaj cov neeg kho tshuab hais. Cov tshuaj nquag ntawm cov tshuaj yog: trometamol, potassium chloride, sodium chloride. Nyob rau hauv kev sib xyaw ua ke ntawm trometamol N, ntawm cov ntu sib txuas, cov khoom ntawm glacial acetic acid tuaj yeem sau tseg, ntxiv rau dej rau kev txhaj tshuaj.

Cov tshuaj tau muab ntim rau ntawm 500 millilitres hauv cov iav fwj, uas tau ntim hauv cov ntawv los qhia. Cov tshuaj lag luam yuav tsum tau muab tshem tawm hauv qhov chaw tsaus. Txee lub neej yog 2 xyoos, tom qab uas cov tshuaj yuav tsum tau muab pov tseg. Cov tshuaj raug muag hauv chav haujlwm kws kho mob sau.

Trometamol H kawg yog dab tsi ?

Kev ua ntawm trometamol N pab txo qis ntawm hydrogen hauv lub cev. Cov tshuaj yeeb dej caw yog qhov hu ua proton acceptor. Ib hom tshuaj zoo rau cov kab mob metabolic thiab ua pa acidosis. Cov tshuaj siv tawm hauv lub raum los ntawm kwv yees li 75 feem pua.

Dab tsi yog qhov qhia tau rau trometamol H ?

Hauv cov lus tim khawv ntawm trometamol N, nws cov lus piav qhia txog kev siv tshuaj metabolic thiab ua pa acidosis, uas tshwm sim hauv daim ntawv hnyav:

Poob siab xeev
Tom Qab Yug Ua acidosis,
Kev kub nyhiab loj
Nrog cerebral edema,
Lub xub ntiag ntawm kev txhab ntshav acidosis los ntawm cov ntshav ncua ntev ntev,
Kev tsim cov cell acidosis tawm tsam keeb kwm ntawm kev kuaj pom tus mob hyperglycemic,
Thaum siv qhov tseem ceeb hu ua kev ua haujlwm sab nrauv ntxiv,
Pulmonary edema nyob rau hauv daim ntawv loj thiab muaj tshuaj lom,
Kev haus cawv nrog methyl cawv ntxiv, ntxiv rau, barbiturates lossis salicylates.

Tsis tas li ntawd, cov tshuaj Trometamol N muaj txiaj ntsig zoo hauv kev txhim kho kev mob tom qab lub raum tsis ua haujlwm.

Cov tshuaj tiv thaiv rau trometamol H yog dab tsi? ?

Hauv contraindications, trometamol N, nws cov lus qhia rau kev siv suav nrog xws li kev txwv:

Tsis txhob siv txoj hauv kev daws teeb meem mus txog ib xyoos,
Nrog rau kev tiv thaiv tsis haum rau cov feem ntawm cov tshuaj,
Nrog hyponatremia,
Tsis txhob sau ntawv tshuaj rau cov tshuaj alkalosis,
Nrog hypokalemia,
Kev ua pa tsis ua hauj lwm hauv daim ntawv them nyiaj, tshwj xeeb, nrog emphysema,
Nrog rau lub cev tsis muaj zog,
Lub davhlau ya nyob twg theem ntawm lub xeev poob siab.

Nrog kev ceev faj, cov tshuaj yog siv rau mob raum los yog mob hepatic tsis txaus.

Dab tsi yog qhov kev siv thiab noj tshuaj ntawm trometamol H ?

Kev siv cov tshuaj trometamol N yog npaj rau kev txuas ntxiv mus rau txoj hnyuv ntxig, uas tau ris tsawg kawg ib teev. Yog tias koj yuav tsum tau siv cov tshuaj nyob rau hnub tom qab, cov koob tshuaj yog pom zoo kom raug txo kom tsawg. Tus kws kho mob teeb tsa qhov koob tshuaj nyob ntawm qhov mob hnyav ntawm acidosis.

Tshwj tsis yog muaj kev txwv tsis pub ua, feem ntau yog qhov tshuaj nruab nrab ntawm trometamol N sib txawv ntawm 5 txog 10 millilitres ntawm trometamol N ib kg lub cev hnyav / teev, uas yuav sib haum rau 500 ml / teev. Hauv qhov no, qhov kev tso cai txhua hnub yuav tsum tsis pub tshaj 1.5 g / kg. Yog tias muaj qhov txaus ntshai ntawm kev koom nrog hypoglycemia, ces cov tshuaj insulin nrog dextrose daws yuav tsum tau muab rau.

Qhov tshwm sim phiv los ntawm trometamol H ?

Feem ntau, cov tshuaj trometamol N tau pom zoo zoo los ntawm cov neeg mob. Yog tias txoj kev lis ntshav ntawm cov tshuaj yog nqa tawm sai sai, qhov no tuaj yeem ua rau qee qhov kev ua kom puas ntawm cov phab ntsa venous, hemolysis tsis raug tshem tawm, ntxiv rau, ntshav siab poob qis, kev txhim kho ntawm venospasm thiab hypokalemia yog yam ntxwv, thiab kev loj hlob ntawm thrombophlebitis, vim qhov kev cuam tshuam ntawm cov nqaij mos hauv zos, tsis cais tawm.

Nrog rau qhov txo nrawm ib feem ntawm cov pa roj carbon dioxide thiab nrog rau kev nce pH tus nqi, kev nyuaj siab ntsws tuaj yeem kuaj pom. Nrog kev nce ntxiv ntawm diuresis, tawm tsam tom qab ntawm kev qhia ntawm cov tshuaj, tus neeg mob yuav muaj hyponatremia, nrog rau hypochloremia. Nrog rau kev txhim kho kev mob tshwm sim ntawm trometamol N, tus neeg mob yuav tsum yauv tsum kho mob zoo ib yam.

Trometamol N - noj ntau dua

Cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm trometamol N: kev ua kom tsis muaj zog, cov leeg ntshav hypotension tau sau tseg, kev nyuaj siab mob ntsws tau sau tseg, hypoglycemia yog txiav txim siab hauv chav kuaj, kev ua txhaum ntawm cov dej-electrolyte tshuav yog tus yam ntxwv, ntxiv rau, kua qaub-lub hauv paus tshuav nyiaj yuav hloov. Qhov tshuaj tiv thaiv tsis muaj nyob. Tus neeg mob yog kws kho ua ntau txoj kev kuaj mob. Yog tias qhov xwm txheej xav tau, tom qab ntawd nqa tawm qhov cua ntawm lub ntsws.

Lub cev ntawm cov tshuaj Tromethamol N rau hauv qhov chaw hu ua tuag tes tuag taw tuaj yeem ua rau cov nqaij hauv zos necrosis, hauv qhov no, kev txhaj tshuaj ntawm cov tshuaj yuav tsum tau ua kom zoo. Tsis tas li ntawd, txhawm rau tiv thaiv kev txhim kho ntawm kev phiv, nws yog ib qho tsim nyog yuav tau qhia tshuaj maj mam. Kev tswj hwm ceev ceev tsuas yog ua tau nrog acidosis, thaum lub plawv ntes tau tshwm sim.

Ua ntej tswj cov tshuaj Tromethamol H, koj yuav tsum paub tseeb tias tsis muaj ib qho tshuaj ntxuav dej hauv cov tshuaj, ntxiv rau, kev ncaj ncees ntawm lub vial yuav tsum tsis txhob muaj kev cuam tshuam. Hauv kev siv cov tshuaj lag luam no, nws yog ib qho tseem ceeb los soj ntsuam theem ntawm cov piam thaj hauv cov ntshav, nrog rau kev txiav txim siab qhov concentration ntawm bicarbonates, thiab yog li qhov raug hu ua diuresis yuav tsum tau nqa tawm.

Yuav ua li cas los hloov trometamol N, dab tsi yog cov analogues ntawm cov tshuaj ?

Cov tshuaj trometamol hais txog analogues ntawm trometamol N.

Lub Npe Lag Luam: Trometamol N

Daim ntawv noj tshuaj:

Kev sib xyaw rau ib 1 liter ntawm kev daws
Yam tshuaj muaj zog:
trometamol - 36.30 g,
poov tshuaj tshuaj dawb - 0.37 g,
sodium tshuaj dawb - 1.75 g.
Cov hle: acetic acid 99%, dej rau kev txhaj tshuaj.
K + - 5 Mm / L, Na + - 30 mM / L, C1 - - 35 Hli / L.
Kev soj ntsuam osmolarity: 470 mOsmol / l.

Kev piav qhia: ntshiab, tsis muaj kob lossis tsis muaj xim, tsis muaj kua, tsis muaj ntxhiab tsw.

Pab pawg kws tshuaj:

ATX Code: B05BB03.

Cov Tshuaj Hauv Tshuaj
Lub hom phiaj ntawm txoj kev kho nrog trometamol N yog kom txo qis ntawm hydrogen ions los ntawm kev qhia cov sib txuas ua yeeb yam raws li cov neeg lees txais H +.

Tromethamol, uas yog ib feem ntawm Tromethamol H, yog tus lees txais proton: tromethamol N 2 С0 3 trometamol-Н + + НС0 3 -

Kev siv ntawm lub hauv paus ntsiab lus ntawm kev kho mob ntawm trometamol tau qhia, ua ntej ntawm txhua tus, hauv qhov xwm txheej ntawm Na + ions cuam tshuam nrog rov qab los ntawm bicarbonate yog qhov tsis tsim nyog rau electrolyte sib npaug, zoo li hauv kev ua pa acidosis, nyob rau hauv uas qhia txog bicarbonate ntxiv rau qhov siab ntawm ib feem ntawm carbon dioxide.

1 M trometamol neutralizes 1 M H 2 C0 3 thiab muab lub cev nrog 1 M bicarbonate. Vim qhov no, qee qhov siab ntawm cov pa roj carbon dioxide thiab cov concentration ntawm hydrogen ions raug txo qis yam tsis cuam tshuam txog ntsws lub luag haujlwm. Yog li, trometamol tuaj yeem siv rau kev ua pa thiab tshuaj metabolic acidosis.

Cov Tshuaj Pharmacokinetics Tromethamol thiab trometamol-N + raug tso tawm los ntawm lub raum tsis hloov, tom qab 8 teev, 75% yog tawm ntawm lub cev. Trometamol undergoes glomerular filtration thiab tsis yauv mus rau tubular resorption, uas yog vim li cas nws, zoo li osmotic diuretics, nce diuresis thiab, nrog khaws cia glomerular pom, yog tawm sai sai. Qhov no ua rau lub raum muaj nuj nqi raws li cov nyhuv ntxiv ntawm trometamol tej zaum yuav xav tau nyob rau hauv metabolic acidosis thiab oliguria.

Kev ntsuas rau siv
Cov foos hnyav ntawm cov metabolic thiab ua pa acidosis:

• tomqab mob acidosis tas,
• transfusion acidosis los ntawm cov ntshav ncua ntev,
• cellosisosis nrog hyperglycemic coma,
• kub nyhiab heev
• kev siv cov ntshav sab nrauv hauv kev phais plawv,
• cerebral edema,
• cov ntaub ntawv tsis zoo ntawm cov mob ntsws ntsws qhuav,
• haumxeeb postoperative lub raum tsis ua hauj lwm,
• lom nrog barbiturates, salicylates thiab methyl cawv.

• Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj,
• cawv,
• mob raum tsis ua haujlwm
• mob ua tsis taus pa ua tsis taus pa (emphysema)
• poob siab nyob rau hauv lub davhlau ya nyob twg theem,
• ua haujlwm dhau
• hypokalemia
• kev npau suav,
• cov me nyuam qis dua 1 xyoos.

Ceev faj: raum qis thiab / lossis daim siab ua haujlwm.

Cev xeeb tub thiab lactation
Kev siv cov tshuaj thaum cev xeeb tub thiab lactation yog ua tau tsuas yog tias lub hom phiaj tau txais txiaj ntsig rau leej niam outweighs qhov pheej hmoo ua rau muaj menyuam lossis menyuam yaus.

Tsuas tshuaj thiab tswj hwm
Cov tshuaj yog npaj rau tsuas rau kev tswj hwm los ntawm lub sijhawm ntev nrog txoj kev lis ntshav rau tsawg kawg ib teev. Yog tias tsim nyog, qhov kev qhia ntawm hnub thib ob thiab hnub txuas ntxiv, cov koob tshuaj yuav tsum raug txo kom tsawg.

Qhov koob tshuaj tau txiav txim siab nyob ntawm qhov mob hnyav ntawm cov kua qaub (acidosis) uas twb muaj lawm. Txoj kev xaiv yog tsom kev tsis haum nyob rau hauv kev tswj hwm ntawm cov kua qaub-lub hauv paus ntawm cov ntshav. Raws li, qhov ntau npaum li cas ntawm trometamol N uas yuav tsum tau ua rau Txoj kev lis ntshav yog sib piv rau xam cov nqi tsis zoo ntawm lub hauv paus loj (BE) thiab lub cev qhov hnyav thiab, tshwj tsis yog muaj lwm qhov sau tseg, yog: 1 ml ntawm trometamol H = BE (mM / L) x kg lub cev hnyav x 2 (coefficient 2 tau txais raws li qhov kev poob qis ntawm qhov tsis muaj peev xwm tom qab ntxiv 100 hli acetate / l).

Dig muag buffering
Yog hais tias cov txuj ci kev txiav txim siab los txiav txim qhov ntsuas ntawm cov kua qaub-hauv lub xeev ntawm cov ntshav tsis muaj, tom qab ntawd, yog tias muaj qhov ntsuas qhov ntsuas, qhov muag tsis pom kev nrog Tromethamol N. tuaj yeem nqa tau. 500 ml / h Qhov koob tshuaj txhua hnub yog -1000 (-2000) ml. Cov koob tshuaj txhua hnub rau cov menyuam yaus los ntawm 1 xyoo yog 10-20 ml ntawm trometamol N / kg lub cev hnyav.

Qhov siab tshaj plaws tau tso cai yog 1.5 g / kg / hnub. Thaum siv cov koob tshuaj loj, nws pom zoo (kom tsis txhob muaj qhov txo qis ntawm cov tshuaj electrolytes hauv cov ntshav) ntxiv rau NaCl ntawm tus nqi ntawm 1 75 g thiab KC1 ntawm tus nqi ntawm 0.372 g rau 1 liter ntawm 3.66% kev daws. Yog tias muaj kev pheej hmoo ntawm hypoglycemia, nws raug nquahu kom muab ib qho tshuaj 5-10 / o daws ntawm dextrose nrog insulin (raws li 1 ntu ntawm insulin ib 4 g ntawm qhuav dextrose).

Sab sij huam
Feem ntau trometamol N muaj kev tiv thaiv zoo. Yog tias txoj kev lis ntshav dhau los dhau lawm, cov hauv qab no tuaj yeem pom: kev voos ntawm phab ntsa ntawm cov leeg ntshav thiab hemolysis, tej zaum yuav txo qis ntshav siab, hypokalemia, venospasm. Vim tias cov nqaij mob ua xua, thrombophlebitis tuaj yeem tsim kho ntawm thaj chaw txhaj tshuaj.

Kev txo qis ntawm ib nrab ceev ntawm cov roj carbon dioxide dioxide thiab nce pH tuaj yeem ua rau ua pa nyuaj siab. Hauv qhov no, nrog kev ua pa acidosis, kev txhaj tshuaj ntawm trometamol H yog qhov kev pom zoo tsuas yog tias nws muaj peev xwm nqa tawm cov pa tawm ntawm lub ntsws. Vim muaj qhov tso tawm ntawm insulin thiab ua kom sai dua ntawm kev siv cov kua nplaum, hypoglycemia tuaj yeem tsim kho ntawm lub qhov txhab.

Raws li kev nce ntxiv diuresis, hyponatremia thiab hypochloremia tuaj yeem tshwm sim. Vim tias hyperkalemia, uas pib txhim kho nyob rau hauv kev sib txuas nrog kev hloov chaw ntawm cellular potassium (tshwj xeeb, nrog lub raum tsis ua haujlwm), thiab vim muaj cov kab mob potassium ntxiv poob, yog tias tsim nyog, soj ntsuam cov qib ntawm cov poov tshuaj hauv ntshav cov ntshav yuav tsum (saib cov lus qhia tshwj xeeb).

Noj ntau dhau
Cov tsos mob kev ua kom tsis muaj zog, cov hlab ntsha hypotension, kev ua pa nyuaj siab, ntshav qab zib, kev ua tsis taus dej-electrolyte tshuav thiab acid-puag qhov tshuav.
Kev Kho Mob: tsis muaj ib qho tshuaj tua kab mob tshwj xeeb. Ua kev kho cov tsos mob, yog tias tsim nyog, siv tshuab ua pa tawm.

Kev cuam tshuam nrog lwm yam tshuaj
Nrog rau kev siv tib lub sijhawm ntawm trometamol H thiab cov tshuaj tiv thaiv kab mob, tej zaum yuav muaj kev sib txuam ntawm hypoglycemic effect (qhov kev pheej hmoo ntawm hypoglycemia), thiab yog li ntawd, kev siv tib lub sijhawm lossis txo cov koob tshuaj ntawm cov tshuaj tiv thaiv kev tiv thaiv kab mob yuav tsum tau zam.

Thaum muab sib xyaw hauv tib lub thawv nrog lwm cov tshuaj, nws yuav tsum tau yug los rau hauv lub siab tias pH tus nqi ntawm kev daws teeb meem ntawm trometamol H yog 8,8-8,7, uas tuaj yeem ua rau kom muaj kev tsim cov nag lossis daus hauv qhov sib xyaw.

Yog tias pom muaj qhov phom sij lossis opalescence thaum tov trometamol N rau hauv ib lub thauv nrog lwm cov kev daws teeb meem rau kev tswj hwm hauv tsoomfwv, tom qab ntawv siv cov tshuaj sib tov no tsis tuaj yeem siv.

Cov nyhuv ntawm narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants yog qhov ua kom zoo dua. Cov nyhuv ntawm cov tsis ncaj ntawm anticoagulants (coumarin derivatives), barbiturates, salicylates nrog kev siv tib lub sijhawm trometamol N. yog lub zog tsis muaj zog.

Cov lus qhia tshwj xeeb
Yog tias cov tshuaj nkag mus rau qhov chaw tuag, nws tuaj yeem ua rau txoj kev loj hlob ntawm cov nqaij hauv lub cev. Muaj qhov txaus ntshai ntawm qhov nyiam ua rau lub ntsws ua pa nyuaj (saib. Sab cuam tshuam).

Hauv kev siv tshuaj, nws yog ib qho tsim nyog los tswj cov ntshav qabzib cov ntsiab lus (phom sij ntawm hypoglycemia), ntshiab si ionograms, bicarbonate concentration, qee qhov siab ntawm cov pa roj carbon dioxide thiab cov kua qaub-lub hauv paus sib npaug, thiab yuam diuresis. Kev siv cov tshuaj rau hauv cov menyuam mos yog tau tsuas yog tias lub hom phiaj tau txais txiaj ntsig ntau dhau qhov pheej hmoo txaus ntshai.

Txhawm rau kom zam kev loj hlob ntawm kev phiv, trometamol yuav tsum tsis txhob siv nyob rau ntawm tus nqi siab. Kev tswj hwm ceev ceev (txog 60 ml / min) raug tso cai tshwj tsis yog (piv txwv, kom tshem tawm cov kab mob acidosis thaum lub caij ntes).

Daim ntawv tso tawm
Kev daws rau Txoj kev lis ntshav. 500 ml txhua yam nyob rau hauv hom kuv pob tshab iav fwj (Heb. F.), kaw nrog hom I bromobutyl roj hmab nres (Heb. F.) rau kev tho thiab lub hau yas hauv qab ntawm txhuas khiav-nrog cov yas yas ntim rau ntawm lub raj mis.
10 lub vials hauv cov thawv ntawv uas muaj cov lus qhia siv (rau tsev kho mob).

Cia rau cov neeg mob
Hauv qhov chaw tsaus li ntawm qhov kub thiab txias tsis siab tshaj 25 ° C. Khaws cov tshuaj kom ncav cuag cov menyuam yaus!

Hnub tas sij hawm
2 xyoos
Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm ntim. Siv tib lub ntshiab hauv vials!

Cov Cai Siv Tshuaj So
Los ntawm tshuaj.

Tuam txhab tsim khoom lag luam
Berlin-Chemie AG Menarini Pab Pawg Glienicker Cov Nqaij Hluav Taws Xob 125 125 12489
Berlin Lub Tebchaws Yelemees

Qhov chaw nyob ntawm Tus Neeg Sawv Cev Chaw Haujlwm hauv Tebchaws Russia
115162 Moscow, st. Shabolovka, lub tsev 31, nplooj B

Cov tshuaj sib piv ntawm cov tshuaj trometamol n raug nthuav tawm, raws li cov ntsiab lus kho mob, hu ua "txhais ua" - cov tshuaj sib hloov tau uas muaj ib lossis ntau yam tib cov tshuaj yeeb dej caw thaum lawv cuam tshuam rau lub cev. Thaum xaiv cov lus txhais, xav txog tsis yog lawv cov nqi nkaus xwb, tab sis kuj yog lub teb chaws ntawm kev tsim khoom thiab lub koob npe ntawm cov neeg tsim khoom.

Sau cov analogues

Ua tib zoo mloog! Daim ntawv muaj cov lus txhais rau cov tshuaj trometamol H, uas muaj cov sib thooj sib thooj, yog li koj tuaj yeem xaiv hloov tus kheej, noj mus rau hauv daim ntawv sau thiab ntau npaum li cas ntawm cov tshuaj uas kws kho mob tau sau tseg. Muab kev nyiam rau cov tuam ntxhab los ntawm Asmeskas, Nyiv, Western Europe, thiab cov tuam txhab lag luam zoo los ntawm Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Hauv / hauv, hauv kev siv tshuaj 3.66%, qhov nruab nrab ntawm cov tshuaj rau ib tus neeg mob uas lub cev hnyav txog 60 kg yog 500 ml / teev (li 120 tee / min). Qhov koob tshuaj yog suav los ntawm cov qauv: K = B x E, qhov twg K yog qhov nyiaj ntawm trometamol tov (ml), B yog qhov nyiaj tsis txaus (mmol / l), E yog tus neeg mob lub cev qhov hnyav (kg). Qhov siab tshaj plaws tau tso cai yog 1.5 g / kg / hnub. Koj tuaj yeem rov nkag dua tsis pub dhau 48-72 teev tom qab kev txhaj tshuaj dhau los, yog tias tsim nyog, kev qhia ntawm hnub ua ntej txo qhov koob tshuaj. Thaum siv cov koob tshuaj siab, nws raug nquahu (kom tsis txhob muaj qhov txo qis ntawm cov tshuaj electrolytes hauv cov ntshav) ntxiv rau NaCl ntawm tus nqi ntawm 1.75 g thiab KCl ntawm tus nqi ntawm 0.372 g rau 1 liv ntawm 3.66% kev daws. Yog tias muaj kev pheej hmoo ntawm hypoglycemia, nws raug nquahu kom muab ib qho kev daws teeb meem 5-10% ntawm dextrose nrog insulin (raws li 1 ntu ntawm insulin ib 4 g ntawm qhuav dextrose).

Cov lus nug, lus teb, tshuaj xyuas ntawm tshuaj Tromethamol N

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv meej tshaj plaws txog cov tshuaj muaj nyob rau hauv cov lus qhia uas tuaj nrog cov neeg ua khoom ntim. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Hnub tas sij hawm

Cov piav suav

Pharmacological pawg ntawm cov tshuaj trometamol

Nosological kev faib tawm (ICD-10)

Cov yam ntxwv ntawm cov tshuaj trometamol

Dawb crystalline hmoov. Yooj yim soluble hauv dej. Cov kua aqueous muaj cov tshuaj tiv thaiv alkaline.

Kws Tshuaj

Nrog rau kev tswj hwm iv, nws txo qis kev ua kom tiav ntawm hydrogen ions thiab nce lub siab cawv ntawm cov ntshav, thiaj li tshem tawm cov acididemia, nkag mus rau hauv lub hlwb rau hauv daim nyias nyias thiab pab tshem tawm cov tshuaj tiv thaiv acidosis, yog tawm tag nrho los ntawm lub raum tsis hloov thiab ua rau lub zog diuresis. Thaum muab tshuaj, nws ua haujlwm li saline laxative.

Kev siv cov tshuaj trometamol

Cov kab mob nrog cov metabolic acidosis, suav nrog mob ntshav qab zib ketoacidosis, lom nrog salicylates, barbiturates, methyl cawv, kev teem caij ntawm allopurinol (kev tiv thaiv ntawm acidosis).

Cov Yuav Tsum Muaj

Cov roj ntsha tsis ua hauj lwm, lub raum tsis ua haujlwm.

Ntawv thov kev txwv

Mob raum thiab / lossis daim siab ua haujlwm, ua pa tsis ua haujlwm.

Kev phiv los ntawm cov tshuaj trometamol

Ua tsis taus pa, hypotension, dyspeptic cuam tshuam, hypoglycemia.

Kev sib txuam

Txhim kho cov txiaj ntsig ntawm narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants, ua kom tsis muaj zog tiv thaiv kev tiv thaiv kabmob (coumarin derivatives), barbiturates, salicylates.

Noj ntau dhau

Nws yog tus cwj pwm los ntawm cov kev mob tshwm sim ntau ntxiv (ua pa ib ce, kev mob siab, xeev siab, ntuav, mob ntshav qab zib). Txoj kev kho yog mob.

Tus thawj coj kev tswj hwm

Kev ceev faj txog cov tshuaj trometamol

Kev soj ntsuam ntawm cov ntsiab lus ntawm cov piam thaj thiab electrolytes ntawm cov ntshav, KShchS yog lub luag haujlwm.

Trometamol N - ib yam tshuaj uas tsim los kho tus mob acidosis. Tus neeg sawv cev yog siv tus yam ntxwv ntawm txoj kev so, uas yog, tswj hwm kom ncaj khov. Kuv yuav txheeb xyuas rau cov nyeem ntawm "Nrov txog Kev Noj Qab Haus Huv" cov lus qhia rau cov khoom lag luam no.

Yog li, kev qhia ntawm trometamol N:

Dab tsi yog trometamol N muaj pes tsawg leeg thiab daim ntawv ntawm kev tso tawm ?

Cov tshuaj Trometamol N muaj nyob rau hauv cov tshuaj tov rau infusion, cov kua yog tsis muaj xim, tsis muaj ntxhiab, yuav tsum tsis muaj cov neeg kho tshuab hais. Cov tshuaj nquag ntawm cov tshuaj yog: trometamol, potassium chloride, sodium chloride. Nyob rau hauv kev sib xyaw ua ke ntawm trometamol N, ntawm cov ntu sib txuas, cov khoom ntawm glacial acetic acid tuaj yeem sau tseg, ntxiv rau dej rau kev txhaj tshuaj.

Cov tshuaj tau muab ntim rau ntawm 500 millilitres hauv cov iav fwj, uas tau ntim hauv cov ntawv los qhia. Cov tshuaj lag luam yuav tsum tau muab tshem tawm hauv qhov chaw tsaus. Txee lub neej yog 2 xyoos, tom qab uas cov tshuaj yuav tsum tau muab pov tseg. Cov tshuaj raug muag hauv chav haujlwm kws kho mob sau.

Trometamol H kawg yog dab tsi ?

Kev ua ntawm trometamol N pab txo qis ntawm hydrogen hauv lub cev. Cov tshuaj yeeb dej caw yog qhov hu ua proton acceptor. Ib hom tshuaj zoo rau cov kab mob metabolic thiab ua pa acidosis. Cov tshuaj siv tawm hauv lub raum los ntawm kwv yees li 75 feem pua.

Dab tsi yog qhov qhia tau rau trometamol H ?

Hauv cov lus tim khawv ntawm trometamol N, nws cov lus piav qhia txog kev siv tshuaj metabolic thiab ua pa acidosis, uas tshwm sim hauv daim ntawv hnyav:

Poob siab xeev
Tom Qab Yug Ua acidosis,
Kev kub nyhiab loj
Nrog cerebral edema,
Lub xub ntiag ntawm kev txhab ntshav acidosis los ntawm cov ntshav ncua ntev ntev,
Kev tsim cov cell acidosis tawm tsam keeb kwm ntawm kev kuaj pom tus mob hyperglycemic,
Thaum siv qhov tseem ceeb hu ua kev ua haujlwm sab nrauv ntxiv,
Pulmonary edema nyob rau hauv daim ntawv loj thiab muaj tshuaj lom,
Kev haus cawv nrog methyl cawv ntxiv, ntxiv rau, barbiturates lossis salicylates.

Tsis tas li ntawd, cov tshuaj Trometamol N muaj txiaj ntsig zoo hauv kev txhim kho kev mob tom qab lub raum tsis ua haujlwm.

Cov tshuaj tiv thaiv rau trometamol H yog dab tsi? ?

Hauv contraindications, trometamol N, nws cov lus qhia rau kev siv suav nrog xws li kev txwv:

Tsis txhob siv txoj hauv kev daws teeb meem mus txog ib xyoos,
Nrog rau kev tiv thaiv tsis haum rau cov feem ntawm cov tshuaj,
Nrog hyponatremia,
Tsis txhob sau ntawv tshuaj rau cov tshuaj alkalosis,
Nrog hypokalemia,
Kev ua pa tsis ua hauj lwm hauv daim ntawv them nyiaj, tshwj xeeb, nrog emphysema,
Nrog rau lub cev tsis muaj zog,
Lub davhlau ya nyob twg theem ntawm lub xeev poob siab.

Nrog kev ceev faj, cov tshuaj yog siv rau mob raum los yog mob hepatic tsis txaus.

Dab tsi yog qhov kev siv thiab noj tshuaj ntawm trometamol H ?

Kev siv cov tshuaj trometamol N yog npaj rau kev txuas ntxiv mus rau txoj hnyuv ntxig, uas tau ris tsawg kawg ib teev. Yog tias koj yuav tsum tau siv cov tshuaj nyob rau hnub tom qab, cov koob tshuaj yog pom zoo kom raug txo kom tsawg. Tus kws kho mob teeb tsa qhov koob tshuaj nyob ntawm qhov mob hnyav ntawm acidosis.

Tshwj tsis yog muaj kev txwv tsis pub ua, feem ntau yog qhov tshuaj nruab nrab ntawm trometamol N sib txawv ntawm 5 txog 10 millilitres ntawm trometamol N ib kg lub cev hnyav / teev, uas yuav sib haum rau 500 ml / teev. Hauv qhov no, qhov kev tso cai txhua hnub yuav tsum tsis pub tshaj 1.5 g / kg. Yog tias muaj qhov txaus ntshai ntawm kev koom nrog hypoglycemia, ces cov tshuaj insulin nrog dextrose daws yuav tsum tau muab rau.

Qhov tshwm sim phiv los ntawm trometamol H ?

Feem ntau, cov tshuaj trometamol N tau pom zoo zoo los ntawm cov neeg mob. Yog tias txoj kev lis ntshav ntawm cov tshuaj yog nqa tawm sai sai, qhov no tuaj yeem ua rau qee qhov kev ua kom puas ntawm cov phab ntsa venous, hemolysis tsis raug tshem tawm, ntxiv rau, ntshav siab poob qis, kev txhim kho ntawm venospasm thiab hypokalemia yog yam ntxwv, thiab kev loj hlob ntawm thrombophlebitis, vim qhov kev cuam tshuam ntawm cov nqaij mos hauv zos, tsis cais tawm.

Nrog rau qhov txo nrawm ib feem ntawm cov pa roj carbon dioxide thiab nrog rau kev nce pH tus nqi, kev nyuaj siab ntsws tuaj yeem kuaj pom. Nrog kev nce ntxiv ntawm diuresis, tawm tsam tom qab ntawm kev qhia ntawm cov tshuaj, tus neeg mob yuav muaj hyponatremia, nrog rau hypochloremia. Nrog rau kev txhim kho kev mob tshwm sim ntawm trometamol N, tus neeg mob yuav tsum yauv tsum kho mob zoo ib yam.

Trometamol N - noj ntau dua

Cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm trometamol N: kev ua kom tsis muaj zog, cov leeg ntshav hypotension tau sau tseg, kev nyuaj siab mob ntsws tau sau tseg, hypoglycemia yog txiav txim siab hauv chav kuaj, kev ua txhaum ntawm cov dej-electrolyte tshuav yog tus yam ntxwv, ntxiv rau, kua qaub-lub hauv paus tshuav nyiaj yuav hloov. Qhov tshuaj tiv thaiv tsis muaj nyob. Tus neeg mob yog kws kho ua ntau txoj kev kuaj mob. Yog tias qhov xwm txheej xav tau, tom qab ntawd nqa tawm qhov cua ntawm lub ntsws.

Lub cev ntawm cov tshuaj Tromethamol N rau hauv qhov chaw hu ua tuag tes tuag taw tuaj yeem ua rau cov nqaij hauv zos necrosis, hauv qhov no, kev txhaj tshuaj ntawm cov tshuaj yuav tsum tau ua kom zoo. Tsis tas li ntawd, txhawm rau tiv thaiv kev txhim kho ntawm kev phiv, nws yog ib qho tsim nyog yuav tau qhia tshuaj maj mam. Kev tswj hwm ceev ceev tsuas yog ua tau nrog acidosis, thaum lub plawv ntes tau tshwm sim.

Ua ntej tswj cov tshuaj Tromethamol H, koj yuav tsum paub tseeb tias tsis muaj ib qho tshuaj ntxuav dej hauv cov tshuaj, ntxiv rau, kev ncaj ncees ntawm lub vial yuav tsum tsis txhob muaj kev cuam tshuam. Hauv kev siv cov tshuaj lag luam no, nws yog ib qho tseem ceeb los soj ntsuam theem ntawm cov piam thaj hauv cov ntshav, nrog rau kev txiav txim siab qhov concentration ntawm bicarbonates, thiab yog li qhov raug hu ua diuresis yuav tsum tau nqa tawm.

Yuav ua li cas los hloov trometamol N, dab tsi yog cov analogues ntawm cov tshuaj ?

Cov tshuaj trometamol hais txog analogues ntawm trometamol N.

Lub Npe Lag Luam: Trometamol N

Lub Npe Tsis Pub Hauv Lub Npe:

Daim ntawv noj tshuaj:

Kev sib xyaw rau ib 1 liter ntawm kev daws
Yam tshuaj muaj zog:
trometamol - 36.30 g,
poov tshuaj tshuaj dawb - 0.37 g,
sodium tshuaj dawb - 1.75 g.
Cov hle: acetic acid 99%, dej rau kev txhaj tshuaj.
K + - 5 Mm / L, Na + - 30 mM / L, C1 - - 35 Hli / L.
Kev soj ntsuam osmolarity: 470 mOsmol / l.

Kev piav qhia: ntshiab, tsis muaj kob lossis tsis muaj xim, tsis muaj kua, tsis muaj ntxhiab tsw.

Pab pawg kws tshuaj:

ATX Code: B05BB03.

Cov Tshuaj Hauv Tshuaj
Lub hom phiaj ntawm txoj kev kho nrog trometamol N yog kom txo qis ntawm hydrogen ions los ntawm kev qhia cov sib txuas ua yeeb yam raws li cov neeg lees txais H +.

Tromethamol, uas yog ib feem ntawm Tromethamol H, yog tus lees txais proton: tromethamol N 2 С0 3 trometamol-Н + + НС0 3 -

Kev siv ntawm lub hauv paus ntsiab lus ntawm kev kho mob ntawm trometamol tau qhia, ua ntej ntawm txhua tus, hauv qhov xwm txheej ntawm Na + ions cuam tshuam nrog rov qab los ntawm bicarbonate yog qhov tsis tsim nyog rau electrolyte sib npaug, zoo li hauv kev ua pa acidosis, nyob rau hauv uas qhia txog bicarbonate ntxiv rau qhov siab ntawm ib feem ntawm carbon dioxide.

1 M trometamol neutralizes 1 M H 2 C0 3 thiab muab lub cev nrog 1 M bicarbonate. Vim qhov no, qee qhov siab ntawm cov pa roj carbon dioxide thiab cov concentration ntawm hydrogen ions raug txo qis yam tsis cuam tshuam txog ntsws lub luag haujlwm. Yog li, trometamol tuaj yeem siv rau kev ua pa thiab tshuaj metabolic acidosis.

Cov Tshuaj Pharmacokinetics Tromethamol thiab trometamol-N + raug tso tawm los ntawm lub raum tsis hloov, tom qab 8 teev, 75% yog tawm ntawm lub cev. Trometamol undergoes glomerular filtration thiab tsis yauv mus rau tubular resorption, uas yog vim li cas nws, zoo li osmotic diuretics, nce diuresis thiab, nrog khaws cia glomerular pom, yog tawm sai sai. Qhov no ua rau lub raum muaj nuj nqi raws li cov nyhuv ntxiv ntawm trometamol tej zaum yuav xav tau nyob rau hauv metabolic acidosis thiab oliguria.

Kev ntsuas rau siv
Cov foos hnyav ntawm cov metabolic thiab ua pa acidosis:

• tomqab mob acidosis tas,
• transfusion acidosis los ntawm cov ntshav ncua ntev,
• cellosisosis nrog hyperglycemic coma,
• kub nyhiab heev
• kev siv cov ntshav sab nrauv hauv kev phais plawv,
• cerebral edema,
• cov ntaub ntawv tsis zoo ntawm cov mob ntsws ntsws qhuav,
• haumxeeb postoperative lub raum tsis ua hauj lwm,
• lom nrog barbiturates, salicylates thiab methyl cawv.

• Hypersensitivity rau lub Cheebtsam ntawm cov tshuaj,
• cawv,
• mob raum tsis ua haujlwm
• mob ua tsis taus pa ua tsis taus pa (emphysema)
• poob siab nyob rau hauv lub davhlau ya nyob twg theem,
• ua haujlwm dhau
• hypokalemia
• kev npau suav,
• cov me nyuam qis dua 1 xyoos.

Ceev faj: raum qis thiab / lossis daim siab ua haujlwm.

Cev xeeb tub thiab lactation
Kev siv cov tshuaj thaum cev xeeb tub thiab lactation yog ua tau tsuas yog tias lub hom phiaj tau txais txiaj ntsig rau leej niam outweighs qhov pheej hmoo ua rau muaj menyuam lossis menyuam yaus.

Tsuas tshuaj thiab tswj hwm
Cov tshuaj yog npaj rau tsuas rau kev tswj hwm los ntawm lub sijhawm ntev nrog txoj kev lis ntshav rau tsawg kawg ib teev. Yog tias tsim nyog, qhov kev qhia ntawm hnub thib ob thiab hnub txuas ntxiv, cov koob tshuaj yuav tsum raug txo kom tsawg.

Qhov koob tshuaj tau txiav txim siab nyob ntawm qhov mob hnyav ntawm cov kua qaub (acidosis) uas twb muaj lawm. Txoj kev xaiv yog tsom kev tsis haum nyob rau hauv kev tswj hwm ntawm cov kua qaub-lub hauv paus ntawm cov ntshav. Raws li, qhov ntau npaum li cas ntawm trometamol N uas yuav tsum tau ua rau Txoj kev lis ntshav yog sib piv rau xam cov nqi tsis zoo ntawm lub hauv paus loj (BE) thiab lub cev qhov hnyav thiab, tshwj tsis yog muaj lwm qhov sau tseg, yog: 1 ml ntawm trometamol H = BE (mM / L) x kg lub cev hnyav x 2 (coefficient 2 tau txais raws li qhov kev poob qis ntawm qhov tsis muaj peev xwm tom qab ntxiv 100 hli acetate / l).

Dig muag buffering
Yog hais tias cov txuj ci kev txiav txim siab los txiav txim qhov ntsuas ntawm cov kua qaub-hauv lub xeev ntawm cov ntshav tsis muaj, tom qab ntawd, yog tias muaj qhov ntsuas qhov ntsuas, qhov muag tsis pom kev nrog Tromethamol N. tuaj yeem nqa tau. 500 ml / h Qhov koob tshuaj txhua hnub yog -1000 (-2000) ml. Cov koob tshuaj txhua hnub rau cov menyuam yaus los ntawm 1 xyoo yog 10-20 ml ntawm trometamol N / kg lub cev hnyav.

Qhov siab tshaj plaws tau tso cai yog 1.5 g / kg / hnub. Thaum siv cov koob tshuaj loj, nws pom zoo (kom tsis txhob muaj qhov txo qis ntawm cov tshuaj electrolytes hauv cov ntshav) ntxiv rau NaCl ntawm tus nqi ntawm 1 75 g thiab KC1 ntawm tus nqi ntawm 0.372 g rau 1 liter ntawm 3.66% kev daws. Yog tias muaj kev pheej hmoo ntawm hypoglycemia, nws raug nquahu kom muab ib qho tshuaj 5-10 / o daws ntawm dextrose nrog insulin (raws li 1 ntu ntawm insulin ib 4 g ntawm qhuav dextrose).

Sab sij huam
Feem ntau trometamol N muaj kev tiv thaiv zoo. Yog tias txoj kev lis ntshav dhau los dhau lawm, cov hauv qab no tuaj yeem pom: kev voos ntawm phab ntsa ntawm cov leeg ntshav thiab hemolysis, tej zaum yuav txo qis ntshav siab, hypokalemia, venospasm. Vim tias cov nqaij mob ua xua, thrombophlebitis tuaj yeem tsim kho ntawm thaj chaw txhaj tshuaj.

Kev txo qis ntawm ib nrab ceev ntawm cov roj carbon dioxide dioxide thiab nce pH tuaj yeem ua rau ua pa nyuaj siab. Hauv qhov no, nrog kev ua pa acidosis, kev txhaj tshuaj ntawm trometamol H yog qhov kev pom zoo tsuas yog tias nws muaj peev xwm nqa tawm cov pa tawm ntawm lub ntsws. Vim muaj qhov tso tawm ntawm insulin thiab ua kom sai dua ntawm kev siv cov kua nplaum, hypoglycemia tuaj yeem tsim kho ntawm lub qhov txhab.

Raws li kev nce ntxiv diuresis, hyponatremia thiab hypochloremia tuaj yeem tshwm sim. Vim tias hyperkalemia, uas pib txhim kho nyob rau hauv kev sib txuas nrog kev hloov chaw ntawm cellular potassium (tshwj xeeb, nrog lub raum tsis ua haujlwm), thiab vim muaj cov kab mob potassium ntxiv poob, yog tias tsim nyog, soj ntsuam cov qib ntawm cov poov tshuaj hauv ntshav cov ntshav yuav tsum (saib cov lus qhia tshwj xeeb).

Noj ntau dhau
Cov tsos mob kev ua kom tsis muaj zog, cov hlab ntsha hypotension, kev ua pa nyuaj siab, ntshav qab zib, kev ua tsis taus dej-electrolyte tshuav thiab acid-puag qhov tshuav.
Kev Kho Mob: tsis muaj ib qho tshuaj tua kab mob tshwj xeeb. Ua kev kho cov tsos mob, yog tias tsim nyog, siv tshuab ua pa tawm.

Kev cuam tshuam nrog lwm yam tshuaj
Nrog rau kev siv tib lub sijhawm ntawm trometamol H thiab cov tshuaj tiv thaiv kab mob, tej zaum yuav muaj kev sib txuam ntawm hypoglycemic effect (qhov kev pheej hmoo ntawm hypoglycemia), thiab yog li ntawd, kev siv tib lub sijhawm lossis txo cov koob tshuaj ntawm cov tshuaj tiv thaiv kev tiv thaiv kab mob yuav tsum tau zam.

Thaum muab sib xyaw hauv tib lub thawv nrog lwm cov tshuaj, nws yuav tsum tau yug los rau hauv lub siab tias pH tus nqi ntawm kev daws teeb meem ntawm trometamol H yog 8,8-8,7, uas tuaj yeem ua rau kom muaj kev tsim cov nag lossis daus hauv qhov sib xyaw.

Yog tias pom muaj qhov phom sij lossis opalescence thaum tov trometamol N rau hauv ib lub thauv nrog lwm cov kev daws teeb meem rau kev tswj hwm hauv tsoomfwv, tom qab ntawv siv cov tshuaj sib tov no tsis tuaj yeem siv.

Cov nyhuv ntawm narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants yog qhov ua kom zoo dua. Cov nyhuv ntawm cov tsis ncaj ntawm anticoagulants (coumarin derivatives), barbiturates, salicylates nrog kev siv tib lub sijhawm trometamol N. yog lub zog tsis muaj zog.

Cov lus qhia tshwj xeeb
Yog tias cov tshuaj nkag mus rau qhov chaw tuag, nws tuaj yeem ua rau txoj kev loj hlob ntawm cov nqaij hauv lub cev. Muaj qhov txaus ntshai ntawm qhov nyiam ua rau lub ntsws ua pa nyuaj (saib. Sab cuam tshuam).

Hauv kev siv tshuaj, nws yog ib qho tsim nyog los tswj cov ntshav qabzib cov ntsiab lus (phom sij ntawm hypoglycemia), ntshiab si ionograms, bicarbonate concentration, qee qhov siab ntawm cov pa roj carbon dioxide thiab cov kua qaub-lub hauv paus sib npaug, thiab yuam diuresis. Kev siv cov tshuaj rau hauv cov menyuam mos yog tau tsuas yog tias lub hom phiaj tau txais txiaj ntsig ntau dhau qhov pheej hmoo txaus ntshai.

Txhawm rau kom zam kev loj hlob ntawm kev phiv, trometamol yuav tsum tsis txhob siv nyob rau ntawm tus nqi siab. Kev tswj hwm ceev ceev (txog 60 ml / min) raug tso cai tshwj tsis yog (piv txwv, kom tshem tawm cov kab mob acidosis thaum lub caij ntes).

Daim ntawv tso tawm
Kev daws rau Txoj kev lis ntshav. 500 ml txhua yam nyob rau hauv hom kuv pob tshab iav fwj (Heb. F.), kaw nrog hom I bromobutyl roj hmab nres (Heb. F.) rau kev tho thiab lub hau yas hauv qab ntawm txhuas khiav-nrog cov yas yas ntim rau ntawm lub raj mis.
10 lub vials hauv cov thawv ntawv uas muaj cov lus qhia siv (rau tsev kho mob).

Cia rau cov neeg mob
Hauv qhov chaw tsaus li ntawm qhov kub thiab txias tsis siab tshaj 25 ° C. Khaws cov tshuaj kom ncav cuag cov menyuam yaus!

Hnub tas sij hawm
2 xyoos
Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm ntim. Siv tib lub ntshiab hauv vials!

Cov Cai Siv Tshuaj So
Los ntawm tshuaj.

Tuam txhab tsim khoom lag luam
Berlin-Chemie AG Menarini Pab Pawg Glienicker Cov Nqaij Hluav Taws Xob 125 125 12489
Berlin Lub Tebchaws Yelemees

Qhov chaw nyob ntawm Tus Neeg Sawv Cev Chaw Haujlwm hauv Tebchaws Russia
115162 Moscow, st. Shabolovka, lub tsev 31, nplooj B

Cov tshuaj sib piv ntawm cov tshuaj trometamol n raug nthuav tawm, raws li cov ntsiab lus kho mob, hu ua "txhais ua" - cov tshuaj sib hloov tau uas muaj ib lossis ntau yam tib cov tshuaj yeeb dej caw thaum lawv cuam tshuam rau lub cev. Thaum xaiv cov lus txhais, xav txog tsis yog lawv cov nqi nkaus xwb, tab sis kuj yog lub teb chaws ntawm kev tsim khoom thiab lub koob npe ntawm cov neeg tsim khoom.

Qhia txog ntawm cov tshuaj

Sau cov analogues

Ua tib zoo mloog! Daim ntawv muaj cov lus txhais rau cov tshuaj trometamol H, uas muaj cov sib thooj sib thooj, yog li koj tuaj yeem xaiv hloov tus kheej, noj mus rau hauv daim ntawv sau thiab ntau npaum li cas ntawm cov tshuaj uas kws kho mob tau sau tseg. Muab kev nyiam rau cov tuam ntxhab los ntawm Asmeskas, Nyiv, Western Europe, thiab cov tuam txhab lag luam zoo los ntawm Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Kev Soj Ntsuam Cov Ntsuam Xyuas

Kev Qhia Txog Cov Neeg Qhua

Cov Qhua Qhia Txog Sab Sij Huam

Cov Neeg Qhua Hais Qhov Ntsuas

Cov qhua tuaj yeem tshaj tawm raws li qhov tau txais ib hnub

Cov Qhua Tuaj Saib Xyuas

Cov neeg qhua qhia txog hnub tas sij hawm

Cov neeg tuaj saib qhia lub sijhawm txais tos

Peb tus qhua tuaj yeem tshaj tawm lub hnub nyoog tus neeg mob

Cov qhua rov xyuas

Cov lus qhia raug rau siv

Trometamol N N

Tus lej sau npe:

Lub Npe Tsis Pub Hauv Lub Npe:

Daim ntawv noj tshuaj:

Pab pawg kws tshuaj:

Cov chaw muag tshuaj

Kev ntsuas rau siv

Cov Yuav Tsum Muaj

Cev xeeb tub thiab lactation

Tsuas tshuaj thiab tswj hwm

Sab sij huam

Noj ntau dhau

Kev cuam tshuam nrog lwm yam tshuaj

Cov lus qhia tshwj xeeb

Daim ntawv tso tawm

Cia rau cov neeg mob

Hnub tas sij hawm

Tso tawm daim ntawv, ntim thiab muaj pes tsawg leeg Trometamol N

Kev daws rau Txoj kev lis ntshav yog pob tshab, tsis muaj xim lossis yuav luag tsis muaj xim, hais dawb, tsis muaj ntxhiab.

Tshwjxeeb: acetic acid 99%, dej d / i.

500 ml - fwj (10) - thawv ntawv thawv.

Qhov ntsuas qhia trometamol N

Cov foos hnyav ntawm cov metabolic thiab ua pa acidosis:

• tomqab mob acidosis tas,
• transfusion acidosis los ntawm cov ntshav ncua ntev,
• cellosisosis nrog hyperglycemic coma,
  kub nyhiab heev
• poob siab
• kev siv cov ntshav sab nrauv hauv kev phais plawv,
• cerebral edema,
• cov ntaub ntawv tsis zoo ntawm cov mob ntsws ntsws qhuav,
• haumxeeb postoperative lub raum tsis ua hauj lwm,
• lom nrog barbiturates, salicylates thiab methyl cawv.

Kev noj tshuaj ntxiv

Cov tshuaj yog npaj rau kev tswj hwm tshuaj tsuas yog los ntawm lub sijhawm ntev nrog txoj kev lis ntshav rau tsawg kawg 1 teev.

Yog tias tsim nyog, qhov kev qhia ntawm hnub thib ob thiab hnub txuas ntxiv, cov koob tshuaj yuav tsum raug txo kom tsawg.

Qhov koob tshuaj tau teeb tsa nyob ntawm qhov mob hnyav ntawm cov mob acidosis uas twb muaj lawm. Txoj kev xaiv yog kev tiv thaiv tsis tuaj yeem tswj tau nyob rau hauv kev tswj hwm ntawm acid-base state ntawm cov ntshav. Raws li, qhov ntau npaum li cas ntawm trometamol N uas yuav tsum tau ua rau Txoj kev lis ntshav yog qhov sib piv rau xam lub hauv paus tsis zoo lub cev (BE) thiab lub cev qhov hnyav thiab, tshwj tsis yog muaj lwm qhov sau tseg, yog: 1 ml ntawm trometamol H = BE (hli / l) x kg lub cev hnyav x 2

(coefficient 2 tau los ntawm kev txo lub peev xwm tom qab ntxiv 100 hli acetate / l).

Yog hais tias cov txuj ci rau kev txiav txim siab qhov ntsuas ntawm acid-hauv paus hauv lub xeev cov ntshav tsis tuaj, tom qab ntawd muaj cov kab mob soj ntsuam, qhov muag tsis pom kev nrog trometamol N.

Tshwj tsis yog muaj kev txwv tsis pub muaj, qhov nruab nrab cov neeg laus koob tshuaj yog 5-10 ml ntawm trometamol N / kg lub cev hnyav / h, uas sib haum rau 500 ml / teev. Qhov koob tshuaj txhua hnub yog 1000 (-2000) ml.

Cov koob tshuaj txhua hnub rau cov menyuam yaus los ntawm 1 xyoo yog 10-20 ml ntawm trometamol N / kg lub cev hnyav.

Qhov siab tshaj plaws tau tso cai yog 1.5 g / kg / hnub.

Thaum siv cov tshuaj siab, nws raug nquahu (kom tsis txhob txo qhov ntsuas ntawm electrolytes hauv cov ntshav) ntxiv rau NaCl ntawm tus nqi ntawm 1.75 g thiab KCl ntawm tus nqi ntawm 0.372 g rau 1 liv ntawm 3.66% kev daws.

Yog tias muaj kev pheej hmoo ntawm hypoglycemia, nws raug nquahu kom muab ib qho kev daws teeb meem 5-10% ntawm dextrose nrog insulin (raws li 1 ntu ntawm insulin ib 4 g ntawm qhuav dextrose).

Sab sij huam

Feem ntau trometamol N muaj kev tiv thaiv zoo. Yog tias qhov infusion tus nqi tsis siab dhau heev, cov hauv qab no tuaj yeem pom: kev voos ntawm phab ntsa ntawm cov leeg ntshav thiab hemolysis, tej zaum yuav txo qis ntshav siab, hypokalemia, venospasm. Vim tias cov nqaij mob ua xua, thrombophlebitis tuaj yeem tsim kho ntawm thaj chaw txhaj tshuaj.

Kev txo qis ntawm ib nrab ceev ntawm cov roj carbon dioxide dioxide thiab nce pH tuaj yeem ua rau ua pa nyuaj siab. Hauv qhov no, nrog kev ua pa acidosis, Txoj kev lis ntshav ntawm trometamol H raug pom zoo tsuas yog muaj qhov ua tau ntawm kev dim pa tawm. Vim tias muaj qhov tawm los ntawm cov tshuaj insulin thiab kev siv lub suab thaj ntau ntxiv nyob rau hauv qhov txuas, qhov mob ntshav qab zib tsawg tuaj yeem tsim kho.

Raws li kev nce ntxiv diuresis, hyponatremia thiab hypochloremia tuaj yeem tshwm sim. Vim tias hyperkalemia, uas pib txhim kho nyob rau hauv kev sib txuas nrog kev hloov chaw ntawm cellular potassium (tshwj xeeb, nrog lub raum tsis ua haujlwm), thiab vim muaj cov kab mob potassium ntxiv poob, yog tias tsim nyog, soj ntsuam cov qib ntawm cov poov tshuaj hauv ntshav cov ntshav yuav tsum (saib cov lus qhia tshwj xeeb).

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tib lub sijhawm ntawm trometamol H thiab cov tshuaj tiv thaiv kab mob, tej zaum yuav muaj kev sib txuam ntawm hypoglycemic effect (qhov kev pheej hmoo ntawm hypoglycemia), thiab yog li ntawd, kev siv tib lub sijhawm lossis txo cov koob tshuaj ntawm cov tshuaj tiv thaiv kev tiv thaiv kab mob yuav tsum tau zam.

Thaum muab sib xyaw hauv tib lub thawv nrog lwm cov tshuaj, nws yuav tsum tau yug los rau hauv lub siab tias pH tus nqi ntawm kev daws teeb meem ntawm trometamol H yog 8,8-8,7, uas tuaj yeem ua rau kom muaj kev tsim cov nag lossis daus hauv qhov sib xyaw.

Yog tias pom muaj qhov phom sij lossis opalescence thaum tov trometamol N rau hauv ib lub thauv nrog lwm cov kev daws teeb meem rau kev tswj hwm hauv tsoomfwv, tom qab ntawv siv cov tshuaj sib tov no tsis tuaj yeem siv.

Cov nyhuv ntawm narcotic analgesics, aminoglycosides, macrolides (erythromycin, oleandomycin), chloramphenicol, tricyclic antidepressants yog qhov ua kom zoo dua.

Cov nyhuv ntawm qhov tsis ncaj ncaj los tiv thaiv coagulants (coumarin derivatives), barbiturates, salicylates, nrog rau kev siv tib lub sijhawm nrog trometamol N., tsis muaj zog.