Emoxibel - cov lus qhia ntawm kev siv

Dosage cov ntaub ntawv ntawm Emoxibel tso tawm:

• daws rau Txoj kev lis ntshav: tsis muaj xim, pob tshab (hauv cov iav fwj ntawm 100 ml, hauv daim ntawv thawv 1 lub khob),
• daws rau kev tso tawm (i / v) thiab intramuscular (i / m) kev tswj hwm: me ntsis xim lossis xim tsis muaj pob tshab, pob tshab (hauv 10 ml vials, hauv 5 ml ampoules, hauv pob blisters ntawm 5 ampoules, hauv daim ntawv tuab cardboard 1 lossis 2 ntim lossis 1 lub raj mis),
• qhov muag tee: nrog daj tint lossis xim tsis muaj xim, pob tshab (hauv hwj 5 ml, hauv thawv ntawv tuab 1 lub khob),
• kev txhaj tshuaj: tsis muaj xim, pob tshab (hauv ampoules ntawm 1 ml, hauv cov hlwv ntim ntawm 5 ampoules, hauv pob ntawv los ntawm 10 ampoules lossis 1 lossis 2 pob nrog ampoule scarifier hauv cov khoom siv).

Muaj pes tsawg leeg ntawm 1 ml Emoxibel Txoj kev lis ntshav kua tshuaj:

• cov tshuaj nquag: methylethylpyridinol hydrochloride (emoxypine) - 0.005 g,
• ntu ntu: dej rau txhaj, sodium chloride.

Kev Koom Tes ntawm 1 ml ntawm kev daws rau iv thiab kev tswj hwm ntawm Emoxibel:

• cov tshuaj nquag: methylethylpyridinol hydrochloride (emoxypine) - 0.03 g,
• ntu ntu: dej rau kev txhaj tshuaj, sodium hydrogen phosphate dodecahydrate, sodium sulfite.

Muaj pes tsawg leeg 1 ml dauv dej ntawm Ophthalmic Emoxibel:

• cov tshuaj nquag: methylethylpyridinol hydrochloride (emoxypine) - 0.01 g,
• Lub cev pabcuam: dej rau kev txhaj tshuaj - txog 1 ml, sodium hydrogen phosphate dodecahydrate - 0.007 5 g, potassium dihydrogen phosphate - 0.006 2 g, sodium benzoate - 0,002 g, sodium sulfite - 0.003 g.

Qhov sib xyaw ntawm 1 ml Emoxibel Txhaj Tshuaj:

• cov tshuaj nquag: methylethylpyridinol hydrochloride (emoxypine) - 0.01 g,
• Cov khoom pabcuam: dej rau kev txhaj tshuaj - txog li 1 ml, hydrochloric acid tov (0.1 M) - 0.02 ml.

Cov Tshuaj Hauv Tshuaj

Ua tsaug rau cov tshuaj nquag uas yog ib feem ntawm Emoxibel, nws ua cov yeeb yam hauv qab no:

• muaj txiaj ntsig zoo cuam tshuam rau cov ntshav coagulation system: lengthens lub sijhawm ntshav coagulation, txo qhov zuag qhia tag nrho coagulation index, inhibits platelet sib sau,
• nce lub tsis kam ntawm cov ntshav liab rau hemolysis thiab kev ua haujlwm ntawm lub cev, ua kom lub zog ntawm cov hlab ntsha thiab cov ntshav liab,
• txhim kho microcirculation,
• nce kev ua si ntawm antioxidant enzymes, zoo inhibits dawb radical oxidation ntawm lipids ntawm biomembranes,
• muaj antitoxic thiab angioprotective cuam tshuam, stabilizes cytochrome P₄₅₀,
• optimizes cov txheej txheem kev siv tshuaj lom neeg hauv cov xwm txheej huab, nrog los ntawm hypoxia thiab nce lipid peroxidation,
• nce lub tsis kam ntawm lub hlwb mus rau ischemia thiab hypoxia,
• nrog ischemic thiab hemorrhagic mob ntawm cerebral ncig txhim kho mnemonic kev khiav dej num, tswj kev kho kom rov qab koom ua ke ntawm lub hlwb, pab txhawb rau kev kho ntawm autonomic dysfunctions,
• txo triglyceride synthesis, muaj lipid-txo cov cuab yeej,
• txo ischemic kev puas tsuaj rau myocardium, dilates hlab ntshav hlab ntsha,
• nrog myocardial infarction, nws ua rau muaj qhov qub ntawm myocardial metabolism, ua kom nrawm nrawm rov qab cov txheej txheem, txwv qhov loj ntawm kev ua kom pom tseeb ntawm necrosis,
• los ntawm kev txo cov xwm txheej ntawm cov mob plawv tsis zoo ua rau muaj kev cuam tshuam hauv chav kho mob myocardial infarction,
• nrog circulatory tsis ua hauj lwm muab cov kev cai ntawm cov txheej txheem redox.

Cov Tshuaj Pharmacokinetics

Cov yam ntxwv ntawm methylethylpyridinol hydrochloride (emoxypine):

• kev nqus: nrog rau / hauv kev taw qhia muaj lub sijhawm txo qis ib nrab hnub (T_½ yog 18 min, uas qhia txog tus nqi siab ntawm kev tshem tawm ntawm cov ntshav), qhov kev tshem tawm tas li yog 0.041 min, qhov tshem tag nrho ntawm Cl yog 214,8 ml ib 1 feeb,
• kev faib tawm: qhov pom tseeb ntawm kev faib tawm - 5.2 l, sai sai rau cov khoom nruab nrog cev thiab cov nqaij ntawm tib neeg lub cev, qhov chaw uas nws tom qab muab tso thiab metabolized,
• cov metabolism: nws muaj 5 metabolites sawv cev los ntawm kev sib xyaw ua ke thiab dealkylated cov khoom ntawm nws txoj kev hloov pauv, cov metabolites yog tawm los ntawm lub raum, 2-ethyl-6-methyl-3-hydroxypyridine-phosphate muaj nyob hauv cov khoom tseem ceeb hauv lub siab,
• kev nthuav tawm: cov kab mob pathological txo tus nqi ntawm nws cov kev nthuav dav, uas nce nws txoj kev nyab xeeb, thiab tseem nce nws lub sijhawm nyob hauv cov hlab ntsha (nws yuav cuam tshuam nrog nws rov qab los ntawm qhov chaw khaws khoom, suav nrog los ntawm ischemic myocardium).

Cov tshuaj pharmacokinetics ntawm Emoxibel hauv kev mob hloov pauv (piv txwv li, nrog rau kev muaj mob ntawm caj dab).

Kev daws rau infusion, kev daws rau iv thiab / m tswj hwm

• postoperative lub sijhawm nyob rau hauv cov neeg mob puas lub hlwb raug mob, ua haujlwm rau kev mob hlwb, mob ntshav qis thiab mob ntshav nrog ua ke nrog rau lub hlwb raug mob, mob taub hau nrog mob hlwb, mob hlwb tsis txaus, mob ntshav hlab plawv tsis txaus, mob hlab ntsha tawg, hemorrhagic mob stroke, ischemic stroke nyob rau hauv lub pas dej ua ke ntawm lub cev carotid leeg thiab hauv txoj hlab pas plab (siv rau cov hlab hlwb thiab lub paj hlwb),
• tsis xis nyob angina pectoris, kev tiv thaiv ntawm reperfusion syndrome, mob myocardial infarction (siv hauv cardiology).

Kev daws rau kev txhaj tshuaj

• kub hnyiab, raug mob, mob cuam tshuam ntawm lub qhov muag,
• detachment ntawm vascular retina ntawm lub qhov muag nrog glaucoma tom qab lub sijhawm postoperative,
• qhuav daim ntawv ntawm angiosclerotic macular degeneration,
• tham myopathy
• chorioretinal dystrophy (nruab nrab thiab ntu ntu),
• angioretinopathy, suav nrog tus mob ntshav qab zib,
• thaj tsam hauv ib qho ntshav ntawm lub cev thiab ntau yam keeb kwm,
• thrombosis ntawm hlab ntsha nruab nrab ntawm Retina thiab nws cov ceg,
• kev tiv thaiv thiab kho qhov muag ntawm qhov muag nrog lub teeb siab (siv hluav taws xob thaum lub sijhawm laser coagulation, lub hnub lub hnub ci).

Cov Yuav Tsum Muaj

• tsis tau muaj 18 xyoo
• cev xeeb tub (tshwj tsis yog kev txhaj tshuaj)
• lactation (tshwj tsis yog txhaj tshuaj)
• kev tsis qaug rau lub zog ntawm cov tshuaj.

Tus txheeb ze (kab mob / mob uas muaj nyob hauv qhov chaw uas tus thawj coj ntawm Emoxibel yuav tsum ceev faj):

• daws rau kev tswj hwm ntawm txoj hnyuv thiab intramuscular: muaj cov tsos mob ntawm kev los ntshav ntau, kev phais, kev ua haujlwm tsis zoo,
• kev txhaj tshuaj: cev xeeb tub, lactation.

Txoj kev daws rau kev tso ntshav thiab intramuscular

Emoxibel yog muab rau hauv / hauv lossis / m. Ua ntej iv kev tswj hwm, txoj kev daws teeb meem nyob rau hauv 200 ml ntawm kev siv 5% dextrose lossis 0.9% sodium chloride.

Kev noj cov tshuaj thiab ncua sijhawm ntawm kev kho yog teem ib leeg.

• neurology, neurosurgery: kev tso dej tawm ntawm 0.01 g rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub ntawm tus nqi ntawm 20-30 tee hauv 1 min rau 10-12 hnub, tom qab ntawd tus neeg mob hloov mus rau kev txhaj tshuaj intramuscular ntawm 0.06-0 , 3 g 2-3 zaug ib hnub rau 20 hnub,
• kev kho plawv: iv poob 0.6-0.9 g 1-3 zaug hauv ib hnub ntawm tus nqi ntawm 20-40 tee hauv 1 feeb rau 5-15 hnub nrog kev hloov mus ntxiv ntawm tus neeg mob mus rau / m tswj kev tswj hwm ntawm 0.06-0 , 3 g ntawm cov tshuaj 2-3 zaug ib hnub twg rau 10-30 hnub.

Cov lus qhia tshwj xeeb

Emoxibel txoj kev kho yog ua nyob rau hauv kev tswj hwm tas li ntawm cov ntshav coagulation thiab ntshav siab.

Kev daws rau Txoj kev lis ntshav yuav tsum tsis txhob tov nrog lwm cov tshuaj.

Ua ntej instillation ntawm lub qhov muag, cov lo ntsiab muag muag yuav tsum tau muab tshem tawm. Tom qab 20 feeb (tsis yog nyuam qhuav pib), lub lo ntsiab muag tuaj yeem hnav dua. Thaum muaj kev sib koom ua ke nrog lwm cov tshuaj kho qhov muag, Emoxibel yog tus ua kom ntev, 15 feeb (tsis yog dhau los) tom qab ua tiav kev nqus ntawm cov tshuaj dhau los.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Thaum pib ntawm kev siv tshuaj tov rau Txoj kev lis ntshav, nrog rau cov neeg mob uas pom tias tsaug zog lossis poob qis hauv ntshav siab tom qab siv cov tshuaj rau iv thiab / m tswj hwm lossis txhaj tshuaj, koj yuav tsum tsis txhob tsav tsheb thiab ua cov haujlwm muaj feem phom sij.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Emoxibel tov rau cov tshuaj ua haujlwm thiab cov tshuaj intramuscular - cov kua yog xim tsis muaj xim lossis me ntsis hauv 5 ml ampoules, muaj:

• Cov tshuaj kom nquag: emoxypine (methylethylpyridinol hydrochloride) - 30 g,
• Cov khoom siv ntxiv: sodium hydrogen phosphate dodecahydrate, sodium sulfite, dej.

Cov pob ntawv ntim ntawm tes 1 lossis 2 pcs. 5 ampoules hauv daim ntawv thawv thawv. Kev qhia, qhwv caj dab.

Daim ntawv noj tshuaj:

Kev piav qhia:
cov kua ntshiab, tsis muaj kob lossis kua xim.

Muaj pes tsawg leeg
1 liter: yam tshuaj: methylethylpyridinol hydrochloride (emoxypine) - 30 g,
tus zam: sodium sulfite, sodium hydrogen phosphate dodecahydrate, dej rau kev txhaj tshuaj.

Pab pawg kws tshuaj:

Txoj Cai: C05CX

Pharmacological kev txiav txim.
Nws yog cov inhibitor ntawm cov txheej txheem dawb radical, antihypoxant thiab antioxidant. Txo cov ntshav viscosity thiab platelet ua ke, nce cov ntsiab lus ntawm cyclic nucleotides (cAMP thiab cGMP) hauv platelets thiab cov leeg hlwb, muaj cov haujlwm fibrinolytic, txo qhov permeability ntawm lub vascular phab ntsa thiab qhov kev pheej hmoo ntawm hemorrhage, txhawb lawv cov resorption. Nthuav cov hlab ntshav, thaum lub sij hawm mob myocardial infarction txwv qhov loj me ntawm kev ua kom pom tseeb ntawm necrosis, txhim kho kev cog lus ntawm lub plawv thiab txoj haujlwm ntawm nws txoj kev ua haujlwm. Nrog cov ntshav siab (BP) muaj qhov ntsuas hypotensive. Hauv cov kev mob ischemic mob tsis zoo ntawm cov hlab hlwb txo qhov mob ntawm cov tsos mob neurological ntau, nce cov ntaub so ntswg tiv thaiv hypoxia thiab ischemia.

Cov Tshuaj Pharmacokinetics
Thaum muab cov tshuaj rau ntawm ib koob ntawm 10 mg / kg, ib nrab-lub neej yog 0.3 teev, kev tshem tag nrho ntawm CL yog 0.2 l / min, qhov pom tseeb ntawm kev faib tawm yog 5.2 l. Cov tshuaj sai sai rau hauv cov kabmob thiab cov ntaub so ntswg, qhov uas nws tau tso thiab metabolized. Tsib metabolites ntawm methylethylpyridinol, sawv cev los ntawm desalkylated thiab conjugated khoom ntawm nws hloov dua siab tshiab, tau pom. Methyl ethyl pyridinol metabolites yog ua tawm los ntawm lub raum. Cov teeb meem loj ntawm 2-ethyl-6-methyl-3-hydroxypyridine-phosphate muaj nyob hauv daim siab. Nrog rau cov kab mob plawv, ua haujlwm bioavailability nce ntxiv.

Kev ntsuas rau siv.
Raws li ib feem ntawm kev kho ua ke: