Yuav siv Metglib li cas?

Txhua tus mob ntshav qab zib »Yuav siv Metglib Force li cas?

Metglib Force hais txog cov neeg sawv cev hypoglycemic. Txhawb nqa ceev ceev normalization ntshav qabzib theem. Nws muaj cov nyhuv ntev ntev. Siv los kho ntshav qab zib hom 2.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm qhov ntau npaum ntawm 2.5 mg + 500 mg thiab 5 mg + 500 mg. Cov khoom tseem ceeb yog glibenclamide thiab metformin hydrochloride. Cov tshuaj seem yog nthuav tawm: hmoov txhuv nplej siab, calcium dihydrate, thiab macrogol thiab povidone, ib qho me me ntawm cellulose.

Zaj duab xis ntawm cov xim dawb xim ntsiav tshuaj 5 mg + 500 mg yog ua los ntawm Opadra dawb, giprolose, talc, titanium dioxide. Cov ntsiav tshuaj muaj txoj kab sib faib.

Cov ntsiav tshuaj 2.5 mg + 500 mg oval, them nrog ib zaj duab xis tiv thaiv nrog xim xim.

Pharmacological kev txiav txim

Nws yog cov koom nrog hypoglycemic tus neeg sawv cev, sulfonylurea derivative ntawm 2 tiam, npaj rau kev tswj hwm qhov ncauj. Nws muaj ob qho tib si pancreatic thiab cov teebmeem ntxiv.

Glibenclamide txhawb kev ua haujlwm zoo ntxiv ntawm cov kua dej los ntawm kev txo qis nws qhov kev nkag siab los ntawm beta hlwb hauv cov txiav. Vim nws cov insulin rhiab heev, nws khi rau cov phiaj xwm hlwb sai dua. Cov txheej txheem ntawm lipolysis ntawm adipose nqaij qeeb qeeb.

Qhov ntshav siab tshaj plaws yog nce mus txog tom qab 2 teev tom qab noj tshuaj. Ib nrab-lub neej ntawm glibenclamide siv sijhawm ntev dua rau lub sijhawm ntev dua li rau metformin (kwv yees 24 teev).

Kev ntsuas rau siv

Kev qhia rau kev siv yog qee yam mob hauv qab no:

• ntshav qab zib hom 2 rau cov neeg laus, yog tias kev noj haus thiab kev tawm dag zog tsis pab,
• tsis muaj txiaj ntsig ntawm kev kho mob nrog sulfonylurea derivatives thiab metformin,
• los hloov monotherapy nrog 2 tshuaj noj hauv cov neeg muaj kev tswj zoo glycemic.

Cov tshuaj yog siv rau cov ntshav qab zib hom 2 hauv cov neeg laus, yog tias kev noj haus thiab kev tawm dag zog tsis pab.

Cov Yuav Tsum Tau Ua

Muaj ntau tus lej sib kis rau kev siv cov tshuaj no tau piav qhia hauv cov lus qhia. Ntawm lawv yog:

• muaj lub cev tsis haum rau lub tshuaj,
• ntshav qab zib hom 1
• raum tsis ua hauj lwm zoo,
• mob ketoacidosis,
• mob hnyav nrog cov nqaij mos hypoxia,
• cev xeeb tub thiab lactation
• kis kab mob
• kev raug mob thiab ua haujlwm dav,
• siv cov miconazole kom nruj,
• cawv intoxication,
• lactic acidosis,
• ua raws li cov khoom noj uas tsis muaj calorie ntau,
• cov me nyuam hnub nyoog qis dua 18 xyoo

Nrog kev saib xyuas zoo, cov tshuaj no tau raug kho rau cov neeg kev txom nyem los ntawm febrile syndrome, kev quav dej cawv, ua tsis taus pa adrenal, lub caj pas pituitary thiab cov thyroid caj pas. Nws kuj tseem ua tib zoo tshuaj rau cov neeg muaj hnub nyoog 45 xyoos thiab laus dua (vim muaj kev pheej hmoo tiv thaiv ntshav qog thiab kab mob lactic acidosis).

Yuav ua li cas coj Metglib Force?

Cov ntsiav tshuaj tsuas yog siv rau qhov ncauj nkaus xwb. Qhov ntau npaum li cas yog xaiv tau ib tus zuj zus, noj mus rau hauv tus account qhov hnyav ntawm qhov kev mob tshwm sim.

Pib nrog 1 ntsiav tshuaj hauv ib hnub nrog kev noj tshuaj ntawm cov tshuaj nquag ntawm 2.5 mg thiab 500 mg, ntsig txog. Maj mam nce qhov koob tshuaj txhua lub lim tiam, tab sis muab qhov loj ntawm glycemia. Nrog kev hloov kho ua ke, tshwj xeeb tshaj yog tias nws yog nqa tawm nyias los ntawm metformin thiab glibenclamide, nws raug nquahu kom haus 2 ntsiav tshuaj ib hnub. Qhov siab tshaj plaws uas pub rau txhua hnub yuav tsum tsis pub tshaj 4 ntsiav tshuaj hauv ib hnub.

Sab sij huam

Thaum kho, kev txhim kho ntawm cov kev phiv tshuaj yog muaj peev xwm:

• leuko- thiab thrombocytopenia,
• anemia
• anaphylactic kev poob siab,
• ntshav qab zib,
• lactic acidosis,
• txo qis nqus ntawm cov vitamins B12,
• saj ua txhaum
• tsis pom kev
• xeev siab
• ntuav
• zawv plab
• tsis qab los noj mov
• zoo nkaus cov khoom hnyav hauv plab
• lub siab ua tsis taus haujlwm,
• rov mob kab mob siab
• kev tsim tawm ntawm daim tawv nqaij
• urticaria
• xau nrog khaus
• erythema
• dermatitis
• qhov nce ntxiv hauv cov concentration ntawm urea thiab creatinine hauv cov ntshav.

Cov tib neeg yuav tsum paub txog kev pheej hmoo ntawm hypoglycemia thiab ntsuas kev tiv thaiv nws ua ntej kom tsav tsheb tom qab lub tsheb lossis pib ua haujlwm nrog cov txheej txheem nyuaj uas xav tau kev nce siab ntawm kev saib xyuas.

Cov lus qhia tshwj xeeb

Cov tshuaj raug muab tso tseg nyob rau hauv kev kho mob ntawm kev kub nyhiab, kis kab mob, kho txoj kev kho mob ua ntej kev phais loj. Hauv cov xwm txheej zoo li no, lawv hloov mus rau insulin txheem. Txoj kev pheej hmoo ntawm kev txhim kho hypoglycemia nce nrog kev txawv txav ntawm kev noj zaub mov, kev yoo mov ntev thiab NSAIDs.

Txwv tsis pub. Cov xaim hluav taws xob nquag dhau los ntawm kev tiv thaiv kab ke ntawm lub cev thiab tuaj yeem cuam tshuam cov txheej txheem ntawm kev hloov khoom nruab nrog.

Koj tsis tuaj yeem noj tshuaj thaum lub sijhawm lactation, vim tias cov tshuaj nquag kis mus rau niam mis. Yog tias xav tau kev kho mob, nws zoo dua kom tso tseg kev pub niam mis.

Siv tsis tau rau hauv kho mob me nyuam yaus.

Tus txiv neej thiab poj niam uas laus dua 65 xyoos yuav tsum tau ceev faj, raws li hauv cov neeg no, qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia yog nce ntxiv.

Lub peev xwm ntawm kev siv yog cuam tshuam los ntawm creatinine tshem tawm. Qhov ntau tshaj nws yog, qhov tsawg dua cov tshuaj tau sau tseg. Yog hais tias tus neeg mob tus mob hnyav dua, nws yog qhov zoo dua rau tsis kam kho cov kev kho mob.

Kev txais yog tsis tuaj yeem lees paub yog tias kuaj lub siab tsis ua haujlwm. Qhov no nthuav tawm cov kev ua haujlwm uas muaj sia nyob hauv daim siab thiab pab txhawb kom tsis txhob ua kom lub siab ua haujlwm ntawm kev kuaj ntshav.

Noj ntau dhau

Nrog kev siv tshuaj ntau dhau, mob ntshav qab zib tsawg. Cov neeg kawm ntawv siab yuav kho tau los ntawm kev siv cov zaub mov ua kom muaj suab thaj thiab carbohydrate nrawm. Tej zaum koj yuav xav tau koob tshuaj lossis hloov kev noj haus.

Hauv cov xwm txheej loj, nrog rau kev tsis nco qab lawm, mob hlwb lossis mob ntshav qab zib tsis nco qab, cov kua dej qabzib lossis tshuaj pleev ntshav qabzib yog siv tau. Tom qab qhov no, nws raug nquahu kom pub cov neeg noj zaub mov nplua nuj nyob hauv cov khoom noj sai.

Hauv cov neeg mob uas muaj mob hepatic, qhov kev tshem tawm ntawm glibenclamide nce. Cov tshuaj tsis tawm los ntawm lim ntshav, vim yog glibenclamide khi zoo rau cov ntshav protein.

Kev noj ntau dhau tsuas yog kho tau hauv chaw kho mob hauv tsev kho mob, thaum nws los txog cov mob lactic acidosis. Qhov ua tau zoo tshaj plaws hauv qhov no yog hemodialysis.

Kev cuam tshuam nrog lwm yam tshuaj

Kev siv miconazole tib lub sijhawm, fluconazole ua rau muaj kev txo qis qis dua. Phenylbutazone nres qhov kev khi ntawm cov tshuaj nquag rau cov txheej txheem protein, uas ua rau cov ntshav qog ntshav thiab lawv cov kev txuam nrog hauv cov ntshav ntshav.

Cov tshuaj noj nrog cov ntsiab lus iodine siv hauv kev xoo hluav taws xob feem ntau cuam tshuam lub raum kev ua haujlwm thiab metformin ceev. Qhov no provokes qhov tshwm sim ntawm lactic acidosis.

Ethanol ua rau muaj kev cuam tshuam disulfiram-zoo li. Diuretics txo qhov txiaj ntsig zoo ntawm kev cuam tshuam ntawm cov tshuaj. ACE inhibitors thiab beta-blockers ua rau lub xeev hypoglycemic.

Tsis txhob noj tshuaj nrog cawv. Qhov no ua rau cov ntshav qog ntshav qab zib, ua rau muaj kev phiv ntau dua.

Muaj ib daim ntawv teev cov analogues ntawm cov tshuaj no, zoo ib yam li nws nyob hauv cov khoom sib txuam thiab cov nyhuv:

• Bagomet Plus,
• Glibenfage
• Glibomet,
• Glucovans,
• Gluconorm,
• Gluconorm Plus,
• Metglib.

Kev txheeb xyuas txog Metglib Force

Moroz V. A., 38 xyoo, endocrinologist, Arkhangelsk: “Cov tshuaj no ua haujlwm zoo. Tam sim no kuv sim mus taw nws ntau zaus. Qab zib yuav ua kom cov ntshav qab zib tau zoo, tsis muaj kev mob tshwm sim. "

Kozerod A.I., 50 xyoo, endocrinologist, Novosibirsk: “Kuv nyiam cov tshuaj no, nws pom zoo los ntawm cov neeg mob. Kuv sau ntawv yuav tshuaj feem ntau, tab sis ua ntej yuav mus ntsib kws kho mob Kuv yuav tsum paub tias muaj lub tsev muag tshuaj twg. ”

Veronika, 32 xyoo, Moscow: “Kuv niam tau mob ntshav qab zib tau ntev los lawm. Thaum xub thawj nws raug kho nrog Glybomet. Tab sis thaum nws yog qhov tsim nyog yuav tau nce lub koob tshuaj, nws dhau los ua qhov siv nyiaj ntau. Lub glibomet raug hloov los ntawm Metglib Force, uas yog ib nrab pheej yig dua. Cov tshuaj ua ib txoj haujlwm zoo, txawm tias muaj kev ua txhaum ntawm kev noj haus. Qab zib yog khaws cia nyob rau theem, Cov ntshav qog ntshav qab zib tsis tau ntev. Qhov tsis zoo tsuas yog tias nws nyuaj nrhiav hauv cov khw muag tshuaj. "

Roman, 49 xyoo, Yaroslavl: “Thaum kuv cov suab thaj txog 30 thiab kuv tsis tau xav tias mus rau tsev kho mob, Kuv pom tias muaj ntshav qab zib. Lawv pib ua cov tshuaj insulin. Tom qab ntawd kuv pib xav nrog tus kws kho mob seb nws puas tuaj yeem hloov ntawm kev txhaj tshuaj mus rau ntsiav tshuaj. Tus kws kho mob tau hais tias sim ua cov Metglib Force ntsiav tshuaj. Kuv tau siv nws tau 2 xyoos, Kuv txaus siab. Qab zib yog ib txwm khaws cia hauv qib, tsis muaj qhov qia rau lub sijhawm ntev.

Valeria, 51 xyoo, Chelyabinsk: “Kuv haus cov tshuaj no tau ib xyoos. Qab zib yog qhov qub, tsis muaj kev mob ntshav qab zib, tab sis kuv xav tias nyob tsis zoo, muaj kev xeev siab tas li. Nws tau muab tawm tias kuv muaj teeb meem nrog cov thyroid caj pas. Tam sim no peb xaiv txoj kev kho kom haum. Tus kws kho mob tawm cov ntsiav tshuaj ntawm Metglib Force. Nws ua tau zoo heev. "

Pharmacological thaj chaw ntawm cov tshuaj Glibomet

Cov Tshuaj Hauv Tshuaj Glibomet yog kev sib txuas ntawm glibenclamide thiab metformin. Cov kev sib xyaw ua ke ntawm ob qho kev sib txuam yog tias muaj kev ua kom muaj kev zais ntawm cov tshuaj insulin endogenous tshwm sim los ntawm glibenclamide, thiab qhov nce ntxiv ntawm kev siv cov piam thaj los ntawm cov leeg nqaij vim qhov kev ua ntawm metformin. Qhov no ua rau muaj qhov tseem ceeb synergistic, uas tso cai rau txo qis koob tshuaj ntawm txhua qhov sib txuam ntawm cov tshuaj, yog li txo qhov ntau dhau ntawm kev mob hlwb ntawm pancreatic β-hlwb thiab txoj kev pheej hmoo ntawm kev txhim kho lawv cov kev ua haujlwm tsis txaus, ua rau txo kev pheej hmoo ntawm kev phiv.
Cov Tshuaj Pharmacokinetics Li ntawm 84% ntawm glibenclamide yog nqus hauv cov hnyuv. Nws yog cov tshuaj nyob rau hauv daim siab nrog kev tsim cov roj ntsha tsis muaj zog, tawm hauv cov quav thiab zis. Ib nrab-lub neej yog 5 teev.Qhov theem ntawm kev muab khi rau ntshav plasma yog 97%.
Metformin, adsorbed nyob rau hauv cov hnyuv, sai sai ua rau hauv cov quav thiab tso zis, tsis khi rau cov ntshav plasma, thiab tsis yog metabolized hauv lub cev. Qhov kev tshem tawm ib nrab-lub neej yog kwv yees li 2 teev.

Kev siv ntawm cov tshuaj Glibomet

Cov koob tshuaj txhua hnub thiab lub sijhawm siv tshuaj yog txiav txim siab ib tus zuj zus los ntawm tus kws kho mob raws li tus neeg mob lub cev metabolic. Thawj koob tshuaj rau cov neeg laus feem ntau yog 2 ntsiav tshuaj ib hnub (noj 1 ntsiav tshuaj thaum sawv ntxov thiab yav tsaus ntuj nrog zaub mov), koob tshuaj txhua hnub yuav tsum tsis pub tshaj 6 ntsiav tshuaj (2 ntsiav tshuaj 3 zaug hauv ib hnub nrog pluas noj). Tso rau hauv qhov siv tshuaj tsawg kawg, muab kev tswj kom txaus ntawm theem ntawm glycemia. Kev noj tshuaj txhua hnub raws lub sijhawm tuaj yeem maj mam txo kom txog thaum qhov kev txhaj tshuaj tsawg kawg txaus kom tswj tau cov ntshav ntshav qabzib tau mus txog.

Phiv fab ntawm cov tshuaj Glibomet

Muaj qee zaus, kev txhim kho hypoglycemia yog ua tau, tshwj xeeb tshaj yog nyob rau cov neeg mob debilitated, cov neeg laus, nrog kev ua si txawv, nrog rau noj tsis xwm yeem lossis haus cawv, yog tias lub siab tsis ua haujlwm thiab lub raum tsis ua haujlwm. Qee zaum muaj mob taub hau, mob plab zom mov: xeev siab, tsis xav noj mov, mob plab, ntuav, raws plab, yuav tsum tsis kho kev kho mob. Qee zaum, kev tawm tsam ntawm tawv nqaij tshwm sim, feem ntau lawv yog ib ntus thiab ploj lawv tus kheej nrog kev kho mob txuas ntxiv. Cov xwm txheej tau piav qhia hauv cov ntaub ntawv ntawm kev muaj peev xwm nthuav dav ntawm metabolic acidosis thaum kho metformin yog qhov tsawg. Txawm li cas los xij, nws tau ntseeg tau qhia tias nyob rau hauv cov neeg mob uas muaj kev pheej hmoo, xws li lub raum thiab mob plawv tsis ua haujlwm, tus mob no tuaj yeem ua rau mob hnyav yog tias kev kho nrog cov tshuaj tsis nres tam sim thiab kev kho mob tsim nyog tsis tau noj. Cov xwm txheej ntawm kev nce qib hauv cov lactic acid hauv cov ntshav dej, ib qho kev nce ntawm cov coefficient ntawm lactate / pyruvate, ib qho kev txo qis hauv cov ntshav pH thiab hyperazotemia tau tshaj tawm (txhua kis tau piav qhia rau cov neeg mob uas tsis muaj txiaj ntsig ntawm ntshav qab zib). Kev tsim cov khoom noj tiv thaiv metabolic acidosis tuaj yeem ua rau kom haus cawv tib lub sijhawm thaum siv nrog cov tshuaj. Hematopoiesis yog qhov tsis tshua muaj thiab feem ntau yog qhov thim rov qab.

Kev sib cuam tshuam yeeb tshuaj Glibomet

Cov nyhuv hypoglycemic ntawm glibenclamide yog potentiated los ntawm dicumarol thiab nws cov derivatives, MAO inhibitors, tshuaj sulfonamide, phenylbutazone thiab nws cov derivatives, chloramphenicol, cyclophosphamide, probenecid, pheniramine, salicylates, miconazole rau qhov ncauj ntawm cov tshuaj, sulfinpyrazone, siab tshuaj. Cov nyhuv ntawm glibenclamide tuaj yeem ua kom tsis muaj zog nrog kev siv tib lub sijhawm ntawm epinephrine, corticosteroids, tshuaj tiv thaiv qhov ncauj, thiazide diuretics thiab barbiturates. Ceev faj yuav tsum tawm dag zog thaum siv β-adrenergic receptors nrog blockers. Nws yuav tsum tau yug los hauv lub siab tias biguanides tuaj yeem txhim kho cov nyhuv ntawm cov tshuaj tiv thaiv.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Cov tshuaj noj yog noj ntawm qhov ncauj, nrog noj mov. Metglib kev noj tshuaj ntau dua yog xaiv tau ib tus zuj zus, nyob ntawm lub xeev cov metabolism.

Feem ntau, pib siv tshuaj ntawm Metglib yog 1 ntsiav tshuaj (2.5 mg glibenclamide thiab 500 mg metformin), nrog rau qhov tshuaj tiv thaiv maj mam xaiv txhua 1-2 asthiv, nyob ntawm tus lej glycemic.

Thaum hloov cov kev sib txuas ua ke yav dhau los nrog metformin thiab glibenclamide (raws li nyias muaj nyias), 1-2 ntsiav tshuaj (2.5 mg glibenclamide thiab 500 mg metformin) yog tshuaj, nyob ntawm qhov koob tshuaj dhau los ntawm txhua feem.

Qhov siab tshaj plaws niaj hnub noj yog 4 ntsiav tshuaj (2.5 lossis 5 mg ntawm glibenclamide thiab 500 mg ntawm metformin).

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Muaj nyob rau hauv daim ntawv ntawm puag ncig biconvex ntsiav tshuaj coated nrog lub plhaub dawb. Cov ntsiav tshuaj tau ntim rau hauv cov hlwv ntawm 20 daim. Lawv raug muag hauv cardboard pob ntawm 2, 3 lossis 5 blisters.

Cov lus qhia rau kev siv Glibomet (txoj kev thiab qhov ntau npaum li cas)

Tus kws kho mob teeb tsa cov tshuaj ntau npaum li cas thiab lub sijhawm rau kev kho mob ib tus zuj zus, nyob ntawm tus neeg mob cov ntshav qab zib cov ntshav thiab lub xeev ntawm nws cov metabolism hauv plhaws.

Thawj koob yuav tsum yog 1-3 ntsiav tshuaj nyob rau ib hnub, tom qab ntawd qhov kev xaiv maj mam ntawm kev siv tau zoo tshaj plaws.

Siv sijhawm ib hnub ob zaug thaum noj tshais thiab noj hmo. Cov koob tshuaj txhua hnub raws li cov lus qhia yuav tsum tsis pub tshaj 6 ntsiav tshuaj.

Yeeb tshuaj sib cuam tshuam

• Cov nyhuv hypoglycemic ntawm cov tshuaj tej zaum yuav nce me ntsis thaum noj nws nrog dicumarol thiab nws cov derivatives, beta-blockers, cimetidine, oxytetracycline, sulfanilamides, allopurinol, MAO inhibitors, phenylbutazone thiab nws cov derivatives, probenecid, chloramphenicol, salicylinone anionone ntau ntau.
• Cov nyhuv ntawm cov tshuaj tuaj yeem txo qis nrog kev siv ua ke nrog epinephrine, cov thyroid hormones, glucocorticoids, barbiturates, thiazide diuretics thiab tshuaj tiv thaiv qhov ncauj.
• Nrog rau kev siv thooj txhij nrog cov tshuaj anticoagulants, qhov nce ntawm cov nyhuv tom qab yog ua tau.
• Thaum noj nrog cimetidine, qhov kev pheej hmoo ntawm kev tsim muaj cov kab mob lactic acidosis nce.

Nqe hauv chaw muag tshuaj

Nqe Glibomet rau 1 pob pib los ntawm 280 rubles.

Cov lus piav qhia nyob rau nplooj ntawv no yog tso ua kev suav daws ntawm kev sau ntawv ntawm cov tshuaj. Cov ntaub ntawv yog muab rau kev ua ntaub ntawv xov xwm nkaus xwb thiab tsis yog kev qhia rau kev coj tus kheej.Ua ntej yuav siv cov tshuaj, koj yuav tsum sab laj tus kws tshaj lij thiab paub koj tus kheej nrog cov lus qhia pom zoo los ntawm cov kws tsim khoom.