Biosulin® P (Biosulin R)

Biosulin P yog cov tshuaj uas yog ib qho tshuaj noj ntawm tib neeg luv luv ua rau endogenous insulin. Cov tshuaj insulin no tau los ntawm kev tsim hluav taws xob, los ntawm qhov ntawd, raws li kev faib tawm, Biosulin P yog cov pab pawg ntawm tib neeg cov tshuaj tiv thaiv ua kom tsis muaj zog.

Qhov pib ntawm kev nqis tes ua tshwm sim tom qab 30-60 feeb thiab pom rau 6-8 teev.

Cov tshuaj insulin muaj nyob thoob plaws lub cev vim tias nws koom nrog yuav luag txhua qhov kev zom zaub mov thiab ua rau muaj kev cuam tshuam ntau ntawm cov tshuaj tiv thaiv. Tab sis lub plab hnyuv siab raum tseem ceeb rau insulin yog daim siab, cov leeg thiab cov nplais adipose. Cov teebmeem hauv biology ntawm insulin:

• cov kev cai ntawm cov metabolism hauv kev ua kom muaj txiaj ntsig vim muaj kev thauj khoom ntau ntxiv thiab siv cov piam thaj los ntawm hlwb, vim cov kab mob siab glycogen no tau tsim,
• kev txwv tsis pub muaj cov kua nplaum hauv lub cev vim tias kev tiv thaiv lub siab glycogen thiab txo cov piam thaj nyob hauv lwm qhov chaw,
• kev koom tes hauv cov metabolism hauv cov rog, tshwm sim los ntawm kev txo qis hauv lawv cov rog, uas ua rau txo qis hauv qhov noj mov ntawm cov rog dawb mus rau hauv cov ntshav,
• thaiv qhov tsim ntawm ketones,
• ntau ntxiv ntawm cov roj ntsha nrog rau lawv cov esterification txuas ntxiv, vim tias qhov tseem ceeb coenzyme yog tsim nyob rau hauv lub cev,
• kev koom tes hauv cov protein metabolism, uas muaj nyob rau hauv kev thauj khoom ntawm cov amino acids rau hauv hlwb, txhawb kev tsim peptides, txo kev noj cov protein los ntawm cov ntaub so ntswg, thiab inhibiting kev tsim cov keto acids los ntawm amino acids.
• kev ua kom tawg los sis inhibition ntawm ntau hom enzymes.

Insulins yog qhov tseem ceeb tshaj plaws ntawm kev hloov pauv hauv kev kho mob ntshav qab zib. Qhov kev xaiv ntawm cov tshuaj yog nyob ntawm qhov mob hnyav thiab cov yam ntxwv ntawm cov chav kawm ntawm tus kab mob, tus neeg mob lub caij thiab qhov nrawm thiab lub sijhawm ntawm cov nyhuv hypoglycemic. Txoj kev kho yog nqa tawm raws li tus neeg lub tswvyim, rau qhov kev npaj tshuaj insulin ntawm ntau lub sijhawm ua haujlwm tau ua ke.

Kev tswj kev noj zaub mov zoo thaum siv insulin yuav tsum tau txwv los ntawm lub zog cov nqi ntawm cov zaub mov los ntawm 1700 txog 3000 kcal.

Thaum xaiv cov koob tshuaj, cov piam thaj hauv ntshav thiab zis yog ntsuas ntawm lub plab khoob thiab thoob plaws ib hnub. Kev txiav txim siab zaum kawg yog yuav txo qis hyperglycemia, glycosuria, nyob ntawm tus neeg mob lub cev.

Biosulin P yog feem ntau muab tshuaj subcutaneously, tsawg zaus - intramuscularly. Qhov nqus thiab lub sijhawm ntawm kev txhim kho ntawm cov nyhuv tsis yog tsuas yog nyob ntawm txoj kev ntawm cov thawj coj, tab sis kuj nyob ntawm qhov chaw, ntau npaum li cas thiab cov tshuaj ntawm cov tshuaj insulin.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Biosulin P yog muaj raws li kev daws rau kev txhaj tshuaj nrog tshuaj ntawm 100 U / 1 ml. Lub raj mis ntim tau 5 ml lossis 10 ml, 1, 2, 3 lossis 5 daim ib pob. Cov chaw tsim khoom ntawm cov tshuaj no yog Marvel LifeSciences (Is Nrias teb).

Nws suav nrog:

• solulin cov kua dej - 100 mg,
• ntau yam zam.

Cov tshuaj yog zwm rau pab pawg ntawm insulins siv rau kev hloov kho, yog tsim los ntawm kev tshuaj ntsuam genetic engineering, thiab raug rau cov tshuaj.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

hauv 10 ml vials, hauv ib pob ntawv los ntawm daim ntawv los ua 1 lub taub ntim lossis hauv daim cartridges ntawm 3 ml, hauv cov hlwv pob 5 pcs.

Kev ntsuas rau siv

• mob ntshav qab zib insulin-hom mob ntshav qab zib hom (hom I),
• non-insulin-hom hom mob ntshav qab zib mellitus (hom II) nrog kev txhim kho ntawm kev tawm tsam tshuaj rau qhov ncauj hypoglycemic,
• non-insulin-hom hom mob ntshav qab zib mellitus (hom II) nrog kev txhim kho ntawm ib feem ntawm cov tshuaj tiv thaiv qhov ncauj hypoglycemic thaum muab kev kho mob sib xyaw,
• cov kab mob intercurrent (mob ceev uas ua rau mob ntshav qab zib mellitus ntawm qee yam),
• decompensation ntawm carbohydrate metabolism, uas yog qhov ua rau muaj xwm txheej ceev rau cov neeg muaj ntshav qab zib.

Ib qho ntxiv, raws li kws kho mob tau sau, insulins tuaj yeem siv rau hauv cov xwm txheej zoo li no:

• hauv kev npaj rau kev phais mob hauv cov neeg mob uas muaj ntshav qab zib hom II,
• mob ntshav qab zib rau cov poj niam cev xeeb tub,
• raws li ib qho tshuaj anabolic hauv qaug zog heev,
• mob furunculosis,
• nrog hyperthyroidism,
• nrog atony lossis ptosis ntawm lub plab,
• nyob rau hauv daim ntawv ntev ntawm tus kab mob siab,
• nrog cirrhosis ntawm daim siab thaum pib ntawm tus kab mob,
• nyob rau hauv ib lub xeev ntawm hypoglycemic coma,
• raws li ib feem ntawm kev kho mob ntawm lub siab tsis ua haujlwm.

Cov Yuav Tsum Tau Ua

Biosulin P yog contraindicated:

• nrog rau kev nkag siab zoo ntxiv rau cov tshuaj nquag lossis lwm yam tshuaj,
• nrog ib lub xeev hypoglycemic ntawm tej keeb kwm,
• nyob rau hauv mob hepatic, pancreatic, mob raum,
• nrog peptic rwj ntawm lub plab zom mov,
• nrog lub siab tsis xws luag hauv theem ntawm decompensation,
• mob plawv tsis ua hauj lwm.

Txoj kev ntawm daim ntawv thov

Cov tshuaj yog muab 30 feeb ua ntej noj mov. Cov ntau npaum yog xaiv los ntawm tus kws kho mob ib leeg zuj zus.

Qhov nyiaj nruab nrab hauv ib hnub yog los ntawm 0.5 txog 1 IU ib kilogram ntawm tus neeg mob lub cev.

Thaum siv Biosulin P ua ib qho yeeb tshuaj, nws raug tswj 3 zaug / hnub lossis nce ntxiv rau 5-6 zaug yog tias tsim nyog. Ntawm qhov koob tshuaj ntau dua 0.6 IU / kg ib hnub, nws yuav tsum siv ntau qhov chaw hauv daim ntawv ntawm 2 lossis ntau dua kev txhaj tshuaj.

Qhov chaw txhaj tshuaj tas li ntawm Biosulin P yog lub plab phab ntsa, tab sis nws tuaj yeem siv rau hauv qab pob, ncej puab, thiab xub pwg. Txhawm rau tiv thaiv kev txhim kho adipose nqaij dystrophy ntawm qhov chaw txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tau hloov.

Intramuscular thiab leeg kev tswj hwm yog nqa tawm tsuas yog nyob ntawm kev saib xyuas ntawm kws kho mob.

Cov lus qhia yog raws li nram no:

• nrog ob tug ntiv tes ua daim tawv nqaij quav,
• ib rab koob tau ntxig rau hauv nws lub hauv paus ntawm kaum ntawm 45 degrees,
• subcutaneously tsav thiab rau kev coj ua tiav, tuav lub koob rau ob peb feeb hauv qab ntawm daim tawv nqaij, tom qab ntawd tshem tawm.

Yog tias ntshav tau tawm ntawm qhov chaw txhaj tshuaj, nias nws nrog koj tus ntiv tes thiab tuav nws.

Sab sij huam

• cov ntshav qog ua ntshav, tshwm sim los ntawm pallor, tawm hws ntau dhau, tachycardia, tshee tshee, nkag ntawm qhov xav, kev tshaib plab. Txhawb cov ntshav qog ntshav qab zib ua rau cov neeg mob qog ua rau lub cev tsis tsaug zog.
• liab, khaus thiab o ntawm thaj chaw txhaj tshuaj,
• adipose ntaub so ntswg dystrophy thaum muab rau hauv ib qho chaw,
• kev tso tshuaj tiv thaiv qhov tsis haum rau daim tawv nqaij, Quincke's edema, anaphylaxis yog qhov tsis tshua muaj tshwm sim,
• o los sis qhov muag pom ntawm thawj theem ntawm txoj kev kho.

Cov laj thawj rau kev txhim kho hauv lub xeev hypoglycemic tuaj yeem yog:

• kev siv tshuaj ntau dhau
• tshuaj hloov
• tsis muaj khoom noj tom qab kev tswj hwm tshuaj,
• ntuav, raws plab,
• ntxiv dag zog ua si,
• cov kab mob nyob rau hauv uas lub cev qhov kev xav txo qis hauv lub cev, xws li pathology ntawm lub siab lossis lub raum, txo qis rau kev ua haujlwm ntawm lub qog adrenal caj pas, pituitary lossis thyroid caj pas,
• cuam ​​tshuam nrog lwm yam tshuaj.

Cov lus qhia tshwj xeeb

• thaum cov xim ntawm kev daws hloov, qhov pom ntawm turbidity lossis hais, ntxiv kev siv yog contraindicated,
• thaum lub sij hawm kho nrog insulin npaj, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam tas li ntawm cov piam thaj hauv cov ntshav,
• nrog rau kev so ntev ntawm kev qhia lossis kev thov siv ntawm cov tshuaj tsis yog, kev txhim kho hyperglycemia yog ua tau, uas tau pom los ntawm kev hnov ​​mob ntawm nqhis dej, tso zis heev, xeev siab thiab ntuav, qhov tshwm ntawm liab thiab dryness ntawm daim tawv nqaij, txo qis qab los noj mov thiab tsis hnov ​​tsw ntawm acetone los ntawm tus neeg mob. Thaum tsis muaj kev kho mob rau tus mob no, nws muaj peev xwm tsim ketoacidosis, uas yog kev phom sij,
• nrog rau kev ua kom lub cev ntau ntxiv, kis mob, kub taub hau, kab mob ntawm cov thyroid caj pas, mob siab, mob raum thiab lwm yam kab mob, nrog rau lub hnub nyoog 65 xyoos thiab hloov kev noj zaub mov, cov koob tshuaj yuav tsum tau kho,
• qee cov kab mob tuaj yeem nce qhov xav tau ntawm insulin (piv txwv li, ntau yam kis nrog kub taub hau siab),
• thaum hloov cov tshuaj, ntshav qab zib tswj yog tsim nyog,
• Biosulin P txo qis ntawm kev haus cawv,
• Kev siv tshuaj insulin twj tsis pom zoo vim tias muaj peev xwm ua kom qaug tshuaj ntawm cov yeeb tshuaj hauv catheters.
• Nrog rau ntau yam kev hloov pauv cuam tshuam nrog kev kho tshuaj insulin, ib qho kev txo qis ntawm kev tsav tsheb lossis kev ua haujlwm uas xav tau kev saib xyuas ntau ntxiv tuaj yeem pom.

Yeeb tshuaj sib cuam tshuam

• nce cov suab thaj txo kev ua haujlwm ntawm Biosulin P raug pom thaum noj: ntsiav tshuaj ntawm cov tshuaj muaj ntshav qab zib, qee cov tshuaj tiv thaiv kab mob, lipid-qis qis, antihypertensive thiab diuretic tshuaj, bromocriptine, octreotide, sulfanilamide thiab tetracycline tshuaj tua kab mob, tshuaj steroid anabolic, ketoconofolamine, phenol cyclofenolamine, cyclol lub hauv paus ntawm lithium, haus cawv muaj tshuaj.
• ib qho kev txo qis hauv cov nyhuv hypoglycemic tshwm sim thaum noj tshuaj tiv thaiv hormonal contraceptives, glucocorticosteroids, cov thyroid hormones, qee cov diuretics thiab tshuaj tiv thaiv kab mob siab, heparin, sympathomimetic tshuaj, danazole, clonidine, antihypertensive tshuaj, diazoxide, narcotic analgesics, nicotine.
• Reserpine tuaj yeem ua kom tsis muaj zog thiab txhim kho kev ua ntawm Biosulin R.

Cov tshuaj Analogues ntawm Biosulin P yog cov luv luv ua insulins thiab tshuaj zoo ib yam li lawv:

• Actrapid NM muaj nyob hauv 10 ml vials. Tus tsim kom muaj: Novo Nordisk (Denmark). Actrapid NM Penfill los ntawm tib lub tuam txhab tsim muaj nyob hauv 3 ml cartridge rau rab qau. Muaj 5 daim cartridge hauv ib pob,
• Vosulim-R kuj tseem tuaj rau hauv daim ntawv ntawm cartridges thiab vials, tsim los ntawm Wockhardt Limited (Is Nrias teb),
• Gensulin R ntawm kev tsim khoom lag luam, tuam txhab tsim khoom lag luam: Bioton Vostok ZAO (Russia),
• Insuman Rapid GT, Aventis Pharma Deutschland GmbH (Lub Tebchaws Yelemees),
• Kev pov hwm R yog tsim los ntawm lub koom haum ntawm Bioorganic Chemistry. Cov kawm paub M.M.Shemyakin thiab Yu.A. Ovchinnikov RAS (Russia),
• Monoinsulin CR, Belmedpreparaty RUE (Koom pheej Belarus),
• Rinsulin R, GEROFARM-Bio OJSC (Russia),
• Rosinsulin R, Medsintez Cog (Russia),
• Humulin Tsis Txaus, Lilly Fabkis (Fabkis).

Cov Tshuaj Hauv Tshuaj

Nws yog tib neeg cov kua dej tau txais los siv siv thev naus laus zis DNA thev naus laus zis.

Nws cuam tshuam nrog kev tsim tshwj xeeb nyob rau sab nraud cytoplasmic membrane ntawm cov hlwb thiab tsim cov txheej txheem insulin-receptor complex uas txhawb cov txheej txheem intracellular, suav nrog synthesis ntawm cov naj npawb ntawm cov enzymes tseem ceeb (hexokinase, pyruvate kinase, glycogen synthetase). Cov thawj coj hauv cov ntshav nyob rau hauv lub cev vim qhov nce ntawm nws txoj kev thauj mus los rau hauv lub cev ntau dua ntxiv, ntau dua qhov kev nqus thiab kev ua haujlwm ntawm cov nqaij mos, ua kom lub ntsej muag lipogenesis, glycogenogenesis, thiab txo tus nqi ntawm cov piam thaj los ntawm lub siab.

Lub sijhawm ntawm kev ua ntawm insulin npaj feem ntau vim yog tus nqi ntawm kev nqus, uas nyob ntawm ntau yam (piv txwv, koob tshuaj, hom thiab qhov chaw ntawm kev tswj hwm), thiab yog li cov ntaub ntawv ntawm kev txiav txim ntawm insulin yog raug rau qhov txawv txav, ob qho tib si hauv tib neeg thiab tib neeg Cov.

Tom qab kev tswj hwm sc, qhov pib ntawm kev ua ntawm cov tshuaj tau sau tseg tom qab kwv yees 30 feeb, cov nyhuv siab tshaj plaws yog nyob hauv qhov sib nrug ntawm 2 thiab 4 teev, lub sijhawm ua haujlwm yog 6-8 teev.

Cov Tshuaj Pharmacokinetics

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm txoj hauv kev ntawm cov thawj coj (sc lossis intramuscularly) thiab qhov chaw tswj hwm (mob plab, ncej puab, pob tw), koob tshuaj (ntim ntawm txhaj tshuaj insulin), thiab cov tshuaj insulin nyob rau hauv kev npaj.

Nws tau faib tawm tsis ncaj hauv daim ntaub. Nws tsis hla tus cwj pwm ntawm lub cev thiab tsis nthuav tawm hauv cov mis niam.

Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum.

T_1/2 - ob peb feeb. Muaj feem nyob hauv cov zis - 30-80%.

Kev taw qhia ntawm cov tshuaj Biosulin ® P

yam 1 mob ntshav qab zib mellitus (insulin-dependant),

hom 2 mob ntshav qab zib mellitus (non-insulin-dependant): theem ntawm kev tawm tsam cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, tiv taus ib feem ntawm cov tshuaj no (thaum kho sib txuam), cov kab mob sib kis,

cov xwm txheej ceev hauv cov neeg mob ntshav qab zib mellitus, nrog los ntawm kev decompensation ntawm carbohydrate metabolism.

Kev sib txuam

Muaj ntau tus yeeb tshuaj uas cuam tshuam rau kev xav tau cov tshuaj insulin.

Hypoglycemic nyhuv ntawm insulin txhim khu qhov ncauj hypoglycemic tshuaj, Mao inhibitors, ACE inhibitors, carbonic anhydrase inhibitors, xim beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, cyclophosphamide, fenfluramine, lithium, tshuaj, muaj ethanol.

Cov tshuaj tiv thaiv tsis haum, tshuaj corticosteroids, cov thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin, nicotine tsis muaj zog tiv thaiv cov ntshav ua kom tsis muaj zog.

Nyob rau hauv kev cuam tshuam ntawm reserpine thiab salicylates, ob qho tib si ua kom tsis muaj zog thiab nce ntxiv hauv kev ua ntawm cov tshuaj muaj peev xwm ua tau.

Noj ntau dhau

Cov tsos mob ntshav qog ntshav yuav pib mob.

Kev Kho Mob: tus neeg mob tuaj yeem tshem tawm qhov mob ntshav qab zib me me los ntawm kev noj cov suab thaj lossis cov khoom noj uas muaj carbohydrate. Yog li, nws raug nquahu rau cov neeg mob ntshav qab zib kom muaj ntshav qab zib, kua txiv mab txiv ntoo lossis lwm yam khoom qab zib nrog lawv.

Hauv cov teeb meem loj, thaum tus neeg mob poob siab, ib qho 40% dextrose daws yog siv tus kab mob, i / m, s / c, iv glucagon. Tom qab nws rov qab nco qab, tus neeg mob tau pom zoo kom noj cov khoom noj uas muaj cov khoom noj carbohydrate kom tiv thaiv kev rov qab txhim kho hypoglycemia.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj tov tau nthuav tawm raws li cov kua xim tsis muaj pob tshab. Raws li lub chaw nquag ua haujlwm, 1 ml ntawm qhov raug tshem tawm muaj 100 IU kev ua haujlwm tiv thaiv tib neeg cov kua dej. Txhawm rau tswj cov pH ntawm cov kua thiab nce bioavailability, cov khoom xyaw nquag yog ntxiv nrog cov khoom hauv qab no:

• metacresol
• dej tsis huv
• 10% caustic sis dej qab zib daws,
• daws ntawm hydrochloric acid ntawm 10% concentration.

Biosulin muaj nyob rau hauv lub khob fwj los yog daim cartridges nrog lub ntim ntawm 3 ml, uas yog tsim rau siv nrog Biomatic Pen mem koob txhaj tshuaj. Ib daim npav cardboard muaj 5 ntim rau hauv cov hlwv qhwv tshuab.

Pharmacological kev txiav txim

Cov tshuaj insulin ua raws cov qauv ntawm tib neeg pancreatic hormone los ntawm DNA recombination. Qhov ua rau lub ntsej muag yog vim muaj qhov khi ntawm cov khoom ua kom nquag plias rau receptors nyob rau sab nraud ntawm lub cell membrane. Ua tsaug rau qhov sib xyaw ua ke no, ib cov kab ke ntawm cov hlwb nrog cov tshuaj insulin yog tsim, uas txhim kho cov enzymatic kev ua haujlwm ntawm hexose-6-phosphotransferase, daim siab glycogen synthesis thiab cov piam thaj. Raws li qhov tshwm sim, txo qis hauv cov ntshav dej qabzib concentration yog pom.

Biosulin P ua rau kom muaj kev tsim cov glycogen thiab fatty acids uas los ntawm cov piam thaj, ua rau cov txheej txheem ntawm gluconeogenesis nyob hauv lub siab.

Kev kho mob ua kom tiav yog ua tiav los ntawm kev nce ntxiv ntawm kev nqus ntawm qab zib los ntawm cov leeg. Nws thauj khoom hauv cov hlwb tau txhim kho. Qhov tsim ntawm glycogen thiab fatty acids los ntawm cov piam thaj nce ntxiv, thiab txheej txheem ntawm gluconeogenesis hauv daim siab ua rau qis qis dua.

Lub sijhawm ntawm cov tshuaj tiv thaiv hypoglycemic yog xam raws li tus nqi ntawm kev sib phoos, uas, nyeg, nyob ntawm qhov chaw thiab cov txheej txheem ntawm kev tswj hwm ntawm insulin, tus yam ntxwv ntawm tus mob ntshav qab zib. Tom qab ua haujlwm subcutaneous, qhov kev kho mob pom tau tom qab ib nrab ib teev thiab nce mus txog qhov siab tshaj plaws ntawm 3 thiab 4 teev tom qab siv lub taub hau. Cov nyhuv hypoglycemic kav rau 6-8 teev.

Bioavailability thiab pib ntawm kev kho mob nyob ntawm cov hauv qab no:

• txoj kev ntawm daim ntawv thov - subcutaneous lossis intramuscular txhaj raug tso cai,
• tus nqi ntawm cov tshuaj hormones
• qhov chaw txhaj tshuaj (lub qhov ncauj plab, qaum ncej, gluteus maximus),
• tshuaj insulin.

Artificially synthesized hormone faib ua tsis sib luag ntawm lub cev. Lub chaw nquag ua haujlwm raug rhuav tshem hauv hepatocytes thiab ob lub raum. Ib nrab-lub neej yog 5-10 feeb. Cov tshuaj nquag tso tawm hauv lub cev ntawm 30-80% nrog zis.

Cov tshuaj insulin muaj cov nyhuv luv luv.

Lub sijhawm tiv thaiv ntawm cov roj ntshav hypoglycemic yog xam raws li tus nqi ntawm assimilation.

Yuav noj Biosulin P li cas

Kev noj tshuaj ntawm cov tshuaj insulin yog txiav txim los ntawm tus kws kho mob nyob ntawm tus kheej, nyob ntawm seb cov ntshav qab zib muaj pes tsawg. Biosulin tso cai raug tswj hwm subcutaneously, nyob rau hauv qhov chaw nrog cov txheej tob ntawm cov leeg thiab mob leeg. Qhov nruab nrab pom zoo noj rau ib hnub rau ib tus neeg laus yog 0.5-1 IU ib 1 kg ntawm qhov hnyav (txog 30-40 units).

Cov kws paub kho mob qhia kom muab cov tshuaj 30 feeb ua ntej pib noj cov zaub mov uas muaj carbohydrate. Hauv qhov no, qhov kub ntawm cov tshuaj muab tshuaj yuav tsum zoo ib yam li qhov ntsuas kub. Nrog rau cov tshuaj monotherapy nrog Biosulin, ib tus neeg sawv cev hypoglycemic raug tswj hwm 3 zaug hauv ib hnub, nyob rau ntawm muaj khoom noj txom ncauj thaum noj mov, qhov ntau zaus ntawm kev txhaj tshuaj nce mus rau 5-6 zaug hauv ib hnub. Yog tias cov tshuaj ntau dua 0.6 IU rau 1 kg ntawm lub cev qhov hnyav, nws yog qhov tsim nyog yuav tau txhaj 2 koob rau ntau qhov chaw ntawm lub cev tsis nyob hauv ib cheeb tsam ntawm lub cev.

Nws yog ib qho tsim nyog yuav tau txhaj tshuaj nyob rau hauv daim tawv nqaij dhau ntawm lub qhov quav ntawm lub leeg nqaij, ua raws cov lus tsim tau ntawm kev ua:

1. Ntawm thaj chaw ntawm qhov kev qhia tawm tswv yim, koj yuav tsum sau cov tawv nqaij hauv pob taws siv siv tus ntiv tes xoo thiab ntiv tes. Lub koob txhaj tshuaj yuav tsum tau muab tso rau hauv daim tawv nqaij quav ntawm kaum ntawm 45 ° thiab lub piston poob qis.
2. Tom qab qhia txog cov tshuaj insulin, koj yuav tsum tawm ntawm rab koob nyob hauv qab daim tawv nqaij 6 feeb lossis ntau feeb kom paub tseeb tias kev siv tshuaj tag nrho.
3. Tom qab tshem rab koob tawm, cov ntshav tawm tuaj ntawm qhov chaw txhaj tshuaj. Lub cheeb tsam cuam tshuam yuav tsum tau nias nrog tus ntiv tes lossis paj rwb ntaub plaub noo noo nrog dej cawv.

Ntxiv mus, txhua qhov kev txhaj tshuaj yuav tsum tau nqa tawm ntawm thaj tsam ntawm thaj chaw anatomical, hloov chaw txhaj tshuaj. Qhov no yog qhov tsim nyog los txo cov kev pheej hmoo ntawm lipodystrophy. Intramuscular kev txhaj tshuaj thiab kev txhaj tshuaj rau hauv txoj hlab ntshav yog nqa tawm los ntawm cov kws kho mob nkaus xwb. Cov tshuaj insulin luv luv ua ke nrog lwm hom tshuaj insulin nrog cov ua kom ntev dua.

Nrog tshuaj monotherapy nrog Biosulin, ib tus neeg sawv cev hypoglycemic yog muab 3 zaug hauv ib hnub.

Cawv tau zoo

Kev haus cawv cawv tsis zoo cuam tshuam rau cov ntshav ncig thiab cov dej num ua haujlwm ntawm nplooj siab thiab raum. Raws li qhov tshwm sim, cov tshuaj insulin metabolism raug cuam tshuam, uas tuaj yeem ua rau cov tswj glycemic poob. Qhov ntxim nyiam ntawm kev txhim kho hypoglycemia yog nce zuj zus. Yog li, hauv lub sijhawm kho nrog tshuaj, nws yog txwv tsis pub haus dej haus cawv.

Cov tshuaj tuaj yeem hloov los ntawm cov yam ntxwv ntawm kev hloov pauv sai:

• Insuman Ceev Heev GT,
• Actrapid NM Penfill,
• Gensulin P,
• Humulin Tsis tu ncua.

Kev txheeb xyuas txog Biosulin P

Cov tshuaj tau tsim nws tus kheej hauv kev lag luam tshuaj vim muaj cov lus teb zoo los ntawm cov kws kho mob thiab cov neeg mob.

Elena Kabluchkova, tus kws kho mob endocrinologist, Nizhny Novgorod

Qhov zoo insulin-based tshuaj uas pab nrog thaum muaj xwm ceev hyperglycemia hauv cov neeg mob ntshav qab zib. Lub koob txhaj tshuaj yog qhov yooj yim rau cov neeg mob uas muaj lub sijhawm hloov pauv ntawm lub neej thiab kev ua haujlwm. Qhov kev txiav txim luv pab ua kom sai sai nrog cov qab zib. Ua tsaug rau qhov ua tiav tau sai ntawm cov nyhuv kho kom zoo, koj tuaj yeem siv lub pob tawb ua ntej noj mov. Biosulin pub rau siv nrog lwm cov tshuaj raws li cov tshuaj insulin ntev ntev. Cov neeg mob tuaj yeem tau txais tshuaj ntawm tus nqi luv.

Olga Atamanchenko, endocrinologist, Yaroslavl

Hauv kev siv tshuaj, kuv tau sau daim ntawv yuav tshuaj rau los ntawm lub Peb Hlis 2015. Nrog kev tawm tsam ntawm hom insulin no hauv cov neeg mob ntshav qab zib, lub neej ua kom zoo dua qub, muaj peev xwm ua kom cov ntshav siab thiab ntshav qab zib tsawg dua. Nws raug tso cai siv rau hauv menyuam yaus thiab poj niam cev xeeb tub. Ua tsaug rau cov tshuaj insulin luv luv, tus neeg mob tuaj yeem muab tshuaj rau thaum muaj xwm txheej ceev (nrog cov ntshav qab zib ntau ntau). Kuv xav txog Biosulin yog txoj kev kho mob sai, muaj txiaj ntsig zoo.

Stanislav Kornilov, 53 xyoo, Lipetsk

Ua tau hauj lwm luv luv insulin. Kuv siv Gensulin thiab Farmasulin, tab sis kuv tuaj yeem ua tiav qhov zoo hauv qabzib tsuas yog ua tsaug rau Biosulin. Cov tshuaj tau ua pov thawj nws tus kheej hauv kev sib xyaw nrog Insuman Bazal - ua haujlwm ntev insulin. Ua tsaug rau qhov ua tau nrawm, nws muaj peev xwm nthuav dav cov khoom noj ntawm cov txiv hmab txiv ntoo. Kuv pom tias los ntawm cov tshuaj dhau los kuv lub taub hau mob feem ntau, tab sis tsis pom qhov tshwm sim no. Kuv txaus siab rau qhov tshwm sim, tab sis lub ntsiab tseem ceeb yog ua raws li cov lus qhia rau kev siv thiab kev noj haus raws cov kws kho kom zoo.

Oksana Rozhkova, 37 xyoo, Vladivostok

5 xyoo dhau los, nws tau nyob rau hauv kev saib xyuas mob siab rau hauv kev sib txuas nrog kev ua kom tsis zoo ntawm ntshav qab zib mellitus, uas nws tsis tau paub txog. Thaum ncav glycemic tswj, tus kws kho mob tau tham txog kev kuaj mob thiab muab Biosulin ua ntu zus. Nws hais tias nws yooj yim dua yog siv tus cwj mem syringe. Thaum cov tshuaj tau txhaj, cov piam thaj tseem nyob hauv ib txwm muaj. Tab sis hom insulin no ua yeeb yam luv luv, thiab nws yog qhov tsim nyog yuav tau xaiv lwm yam sib txawv nrog cov nyhuv ntev dua. Kuv tau ntshai tias cov tshuaj yuav tsis raug, tab sis kev ua xyem xyav tsis tau paub tseeb. Nws yog qhov zoo rau kev sib txuas nrog lwm hom insulin.