Amoxiclav - cov lus qhia rau kev siv, tshuaj xyuas, sib piv thiab ntau npaum li cas (cov ntsiav tshuaj 125 mg, 250 mg, 500 mg, 875 mg, 1000 mg, ncua kev kawm) ntawm cov tshuaj rau kev kho mob kis rau cov laus, menyuam yaus thiab cev xeeb tub

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yeeb AmoxiclavCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Amoxiclav hauv lawv qhov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov cim qhia ntawm Amoxiclav nyob rau hauv muaj cov qauv txheej txheem. Siv rau kev kho mob ntawm ntau yam mob sib kis hauv cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation. Siv dej cawv thiab muaj tshwm sim rau lub cev tom qab noj Amoxiclav.

Amoxiclav - yog kev sib xyaw ntawm amoxicillin - semisynthetic penicillin nrog rau kev pom dav ntawm cov tshuaj tiv thaiv kab mob thiab clavulanic acid - ib qho tsis paub kev tiv thaiv beta-lactamase inhibitor. Clavulanic acid ua rau lub zog ua haujlwm ruaj khov nrog cov enzymes thiab ua kom cov tsis kam ntawm amoxicillin rau cov teebmeem ntawm beta-lactamases uas ua los ntawm cov kab mob me me.

Clavulanic acid, zoo sib xws hauv cov qauv tsim cov tshuaj tua kab mob beta-lactam, muaj qhov ua haujlwm tsis muaj zog tiv thaiv kab mob tua kab mob.

Amoxiclav muaj qhov ntau ntawm cov tshuaj tua kabmob.

Nws nquag ua haujlwm rau cov leeg tsis haum rau amoxicillin, suav nrog qee yam kev tsim cov beta-lactamases, incl. aerobic gram-cov kab mob zoo, cov kab mob aerobic gram-tsis zoo, cov kab mob anaerobic gram-cov kab mob zoo, cov kab mob gram-negative anaerobes.

Cov Tshuaj Pharmacokinetics

Lub ntsiab pharmacokinetic tseem ceeb ntawm amoxicillin thiab clavulanic acid yog qhov zoo sib xws. Ob qhov sib xyaw ua ke tau zoo tom qab noj cov tshuaj hauv, noj mov tsis cuam tshuam rau qib ntawm kev nqus. Ob qhov sib xyaw ua ke los ntawm cov ntim zoo hauv kev faib tawm hauv lub cev thiab cov nqaij (lub ntsws, nruab nrab pob ntseg, dej pleural thiab peritoneal, lub tsev me nyuam, zes qe menyuam, thiab lwm yam). Amoxicillin tseem nkag mus rau hauv cov kua ntshav synovial, mob siab, lub caj pas prostate, palatine tonsils, cov leeg nqaij, lub zais zis, lub zais ntawm cov ntshav, cov qaub ncaug, lub ntsej muag zais zis. Amoxicillin thiab clavulanic acid tsis nkag rau BBB nrog uninflamed meninges. Amoxicillin thiab clavulanic acid hla lub plab placental thiab nyob rau hauv cov nyiaj taug lw yog tawm hauv niam cov kua mis. Amoxicillin thiab clavulanic acid yog qhov cim los ntawm kev khi qis rau cov ntshav protein. Amoxicillin yog qee cov metabolized, clavulanic acid yog pom meej tias muaj cov metabolism hauv lub zog. Amoxicillin ua tawm los ntawm lub raum yuav luag tsis hloov pauv los ntawm tubular tso pa thiab glomerular pom. Clavulanic acid yog tawm los ntawm glomerular pom, ib feem nyob rau hauv daim ntawv ntawm metabolites.

Cov Khoom Qhia

Cov kab mob kis tau los ntawm cov kab mob raug taus ntawm cov kab mob me me:

kis kab mob ntawm cov pa hauv siab thiab cov kabmob ENT (nrog rau mob siab thiab ntev, mob siab thiab ntev oitis media, pharyngeal abscess, tonsillitis, pharyngitis),
kis kab mob ntawm cov pa hauv qis (nrog rau kev mob ntsws zoo nrog cov kab mob superinfection, mob ntsws txhaws ntev, mob ntsws),
mob txeeb zig
cov kab mob gynecological
kis tau ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau tsiaj thiab tib neeg tom,
pob txha thiab mob pob txha mos,
biliary huam mob (cholecystitis, cholangitis),
odontogenic tau tus kab mob.

Tso Tawm Cov Ntawv

Hmoov rau kev npaj cov kev txhaj tshuaj rau cov tshuaj tua kabmob (4) 500 mg, 1000 mg.

Hmoov rau qhov kev npaj tawm ntawm kev ncua rau kev tswj hwm qhov ncauj ntawm 125 mg, 250 mg, 400 mg (daim ntawv yooj yim rau cov menyuam yaus).

Zaj duab xis-cov ntsiav tshuaj 250 mg, 500 mg, 875 mg.

Cov lus qhia rau kev siv thiab ntau npaum li cas

Cov neeg laus thiab menyuam yaus uas muaj hnub nyoog tshaj 12 xyoos (lossis ntau dua 40 kg ntawm lub cev qhov hnyav): cov koob tshuaj ib txwm rau kev sib kis me me mus rau mob hnyav yog 1 ntsiav tshuaj 250 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj 500 + 125 mg txhua 12 teev, nyob rau kis mob hnyav thiab mob ntsws ua pa - 1 ntsiav tshuaj 500 + 125 mg txhua 8 teev lossis 1 ntsiav tshuaj. 875 + 125 mg txhua 12 teev .Tej ntsiav tshuaj tsis yog rau cov menyuam hnub nyoog qis dua 12 xyoos (qis dua 40 kg ntawm lub cev qhov hnyav).

Qhov siab tshaj plaws txhua hnub koob tshuaj clavulanic acid (hauv daim ntawv ntawm cov ntsev ntsev) yog 600 mg rau cov neeg laus thiab 10 mg / kg ntawm lub cev hnyav rau cov menyuam yaus. Qhov koob tshuaj txhua hnub ntawm amoxicillin yog 6 g rau cov neeg laus thiab 45 mg / kg ntawm lub cev hnyav rau cov menyuam yaus.

Lub chav kawm ntawm kev kho mob yog 5-14 hnub. Lub sijhawm tiv thaiv ntawm kev kho mob yog txiav txim los ntawm tus kws khomob koom nrog. Txoj kev kho yuav tsum tsis pub ntev tshaj 14 hnub yam tsis muaj kev kuaj mob zaum ob.

Dosage rau odontogenic kis: 1 tab. 250 +125 mg txhua 8 teev lossis 1 ntsiav tshuaj 500 + 125 mg txhua 12 teev rau 5 hnub.

Muab koob tshuaj rau lub raum tsis ua haujlwm: rau cov neeg mob uas mob raum tsis txaus (Cl creatinine - 10-30 ml / min), cov koob tshuaj yog 1 rooj. 500 + 125 mg txhua 12 teev, rau cov neeg mob uas lub raum tsis ua haujlwm (creatinine Cl tsawg dua 10 ml / min), cov koob tshuaj yog 1 lub rooj. 500 + 125 mg txhua 24 teev

Sab sij huam

Cov kev mob tshwm sim rau feem ntau me me thiab ua ntu zus.

tsis qab los noj mov
xeev siab, ntuav,
zawv plab
mob plab
pruritus, urticaria, erythematous pob,
angioedema,
anaphylactic kev poob siab,
kev tsis haum vasculitis,
exfoliative dermatitis,
Stevens-Johnson mob
thim rov qab leukopenia (suav nrog neutropenia),
thrombocytopenia
hemolytic anemia,
eosinophilia
kiv tob hau, mob taub hau,
mob nriaj (tej zaum yuav tshwm sim rau cov neeg mob uas lub raum lub raum tsis ua haujlwm thaum noj cov tshuaj loj),
kev xav ntawm kev ntxhov siab
insomnia
interstitial nephritis,
crystalluria
kev loj hlob ntawm superinfection (suav nrog candidiasis).

Cov Yuav Tsum Muaj

ua kom lub cev tsis haum rau ib qho twg ntawm cov tshuaj,
cov tshuaj tiv thaiv tsis haum hauv keeb kwm rau penicillins, cephalosporins thiab lwm yam tshuaj tua kab mob beta-lactam,
keeb kwm ua pov thawj ntawm cholestatic jaundice thiab / lossis lwm qhov ua kom lub siab ua tsis zoo los ntawm kev noj cov tshuaj amoxicillin / clavulanic acid,
mob mononucleosis thiab mob lyukhocytic.

Cev xeeb tub thiab lactation

Amoxiclav tuaj yeem raug tshuaj thaum cev xeeb tub yog tias muaj cov cim qhia meej.

Amoxicillin thiab clavulanic acid hauv qee qhov me yog tawm hauv niam cov kua mis.

Cov lus qhia tshwj xeeb

Nrog rau txoj kev kho mob, cov haujlwm ntawm cov ntshav, daim siab thiab lub raum yuav tsum tau saib xyuas.

Hauv cov neeg mob uas lub raum tsis ua haujlwm uas tsis zoo, yuav tsum tau kho txoj kev noj tshuaj ntau dua lossis nce ntxiv nyob nruab nrab ntawm kev noj tshuaj yog xav tau.

Txhawm rau kom txo qis kev phom sij los ntawm kev mob tshwm sim ntawm txoj hnyuv plab, cov tshuaj yuav tsum tau noj nrog pluas noj.

Kev ntsuam xyuas hauv chaw kuaj: cov tshuaj amoxicillin ntau heev muab qhov tsis zoo tsis haum rau cov ntshav qabzib thaum siv Benedict's reagent lossis Felling's solution. Peb nquahu kom muaj Enzymatic tshua nrog glucosidase.

Kev siv cov Amoxiclav nrog rau kev siv cawv ib txhij hauv ib hom twg yog txwv tsis pub, txij li kev pheej hmoo ntawm daim siab thaum noj lawv tib lub sijhawm yog nce ntxiv.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tsis muaj cov ntaub ntawv qhia txog qhov tshwm sim tsis zoo ntawm Amoxiclav nyob rau hauv koob tshuaj pom zoo kom muaj peev xwm tsav lub tsheb lossis ua haujlwm nrog cov qauv.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv tshuaj ib leeg Amoxiclav nrog antacids, glucosamine, laxatives, aminoglycosides, kev nqus qis qis, nrog ascorbic acid - nce ntxiv.

Diuretics, allopurinol, phenylbutazone, NSAIDs thiab lwm yam tshuaj uas thaiv cov hlab zais pa zais ua rau muaj kev cia siab ntawm amoxicillin (clavulanic acid raug cais tawm tshwj xeeb los ntawm glomerular pom).

Nrog rau kev siv tib txhij ntawm Amoxiclav nce lub tshuaj lom ntawm methotrexate.

Nrog rau kev siv tib txhij ntawm Amoxiclav nrog allopurinol, qhov tshwm sim ntawm exanthema nce.

Muab kev tswj hwm nrog disulfiram yuav tsum raug zam.

Qee qhov xwm txheej, kev noj tshuaj tuaj yeem ua kom ntev dua prothrombin lub sijhawm, hauv qhov no, kev ceev faj yuav tsum tau siv thaum lub sij hawm sau tshuaj anticoagulants thiab cov tshuaj Amoxiclav.

Kev sib xyaw ntawm amoxicillin nrog rifampicin yog antagonistic (muaj kev sib txuam ntawm lub zog tiv thaiv kab mob).

Amoxiclav yuav tsum tsis txhob siv nrog cov tshuaj tua kab mob bacteriostatic (macrolides, tetracyclines), sulfonamides vim tias qhov txo qis hauv Amoxiclav cov neeg ua haujlwm tau zoo.

Probenecid txo qis kev zoo ntawm amoxicillin, ua rau muaj kev paub ntau ntxiv.

Cov tshuaj tua kab mob txo qhov ua tau zoo ntawm kev tiv thaiv qhov ncauj.

Cov tshuaj tiv thaiv ntawm cov tshuaj tua kab mob Amoxiclav

Cov qauv ntawm cov qauv ua haujlwm: