Sib piv ntawm Ampicillin thiab Amoxicillin > Kev khomob thiab kev tiv thaiv

Benzipenicillin, uas yog monobasic acid, tsis zoo rau hauv dej thiab tsis ruaj khov, yog li nws tau siv los ua ib qho zoo! soluble ntsev cov ntsev ntawm sodium, potassium, thiab esters. Nws ua rau cov kab mob me nyob ntawm sab hauv lub hlwb xwb.

Gram-positive cocci thiab coli yog nkag siab rau benzylpenicillin sodium ntsev, tshwj xeeb tshaj yog pneumococci (txog 95% ntawm leeg), hemolytic thiab pyogenic streptococci. Txawm li cas los xij, benzylpenicillin ua rau tsuas yog 10% ntawm Staphylococcus aureus leeg, thiab epidermal staphylococcus tiv taus nws. Enterococci ib txwm tiv taus penicillin

Nrog kev qhia txog ntawm IM, cov tshuaj sai thiab nqus tau sai ntawm lub cev. Thaum noj, nws tau sai sai pov tseg los ntawm penicillinases ntawm lub plab hnyuv muaj. Nws tsis ruaj khov nyob rau hauv ib puag ncig acidic, yog li nws tsuas siv tau niam txiv. Qhov nruab nrab kho tshuaj lom ntawm cov tshuaj tua kab mob hauv cov ntshav kav ntev li 3-4 teev.

Qhov theem siab ntawm benzylpenicillin hauv cov ntshav tau txiav txim siab los ntawm lub xeev ntawm daim siab thiab lub raum. Nrog lub raum tsis zoo ua haujlwm | (piv txwv, hauv cov neeg mob anuria) T1 / 2 nce mus txog 4-10 teev, thiab nyob rau hauv cov kev txom nyem los ntawm daim siab mob nws tuaj yeem ncav sijhawm ntev txog 16-30 teev. Benzylpenicillin nkag mus rau hauv cov ntaub so ntswg thiab dej hauv lub cev tshwj tsis yog lub hlwb, lub qhov muag, cov leeg ntshav thiab cov nqaij mos.

Tus nqi tso tawm ntawm cov tshuaj nyob ntawm daim ntawv ntau npaum li cas, txoj kev tswj hwm thiab cov yam ntxwv ntawm tus neeg mob. Kev tshem tawm sai sai ntawm lub cev ua rau xav tau kev mus txhaj tshuaj ib zaug kom ceev cov ntshav siab kom txaus. Txhawm rau tshem tawm qhov tsis zoo no, cov tshuaj tau tsim uas nyuaj rau yaj thiab maj mam nqus, muab cov nyhuv ntev.

Cov tshuaj kho nruab nrab ib koob rau cov tswj hwm kev coj noj coj ua ntawm benzylpenicillin yog 1 lab units, txhua hnub - 6 lab units. Nws tuaj yeem nce ntxiv mus txog 20 lab units lossis ntau dua.

Koj yuav tsum tsis txhob tov cov tshuaj penicillin nrog cov acids, alkalis, cawv, poov tshuaj permanganate, hydrogen peroxide.

Nyob rau hauv cov kev mob hnyav rau paug, penicillin yog muab iv hauv micro-dav hlau lossis nqus dej hauv cov dej lim rau kev txhaj tshuaj lossis isotonic sodium chloride tov. Ntxiv lwm yam tshuaj muaj kuab rau qhov kev daws yog qhov tsis tau. Qhia rau hauv cov leeg li 1-2 zaug hauv ib hnub hauv ua ke nrog kev qhia ntawm cov leeg

Ua raws li qhov mob hnyav ntawm cov txheej txheem sib kis, lub sijhawm ntawm kev kho mob penicillin nyob ntawm ob peb hnub txog 2 hlis lossis ntau dua. Kev siv cov benzylpenicillin yog qhia hauv txhua qhov xwm txheej ntawm qhov raug kuaj pom ntawm lub cev. Cov tshuaj tseem yog cov tshuaj tua kab mob ntawm kev xaiv hauv kev kho mob kev kis mob los ntawm tus kab mob no. Nrog rau endocarditis, kev lees paub ntawm kev nkag siab ntawm cov kab mob coj mus rau benzylpenicillin yog suav tias yog qhov yuav tsum tau ua.

Cov Lus Qhia Tiv Thaiv: muaj keeb kwm kev tsis haum rau cov tshuaj penicillin, mob ntsws asthma.

Oxacillin Sodium Ntsev

• Hais txog rau ib qho hluavtaws penicillins. Raws li qhov pom ntawm antimicrobial kev txiav txim, cov tshuaj zoo ib yam li methicillin. Nws zoo nqus thaum noj qhov ncauj, nws cov bioavailability nyob ntawm kev noj zaub mov, yog li ntawd nws yog qhov zoo dua rau noj oxacillin ntawm ib plab khoob.

Kev kho mob siab rau ntawm cov tshuaj hauv cov ntshav tsuas kav 3 teev tom qab noj 0.5 g los ntawm qhov ncauj ib teev ua ntej noj mov lossis 2-3 teev tom qab nws.

Cov kev daws teeb meem rau kev tswj hwm hauv tsoom niam txiv nyob twj ywm rau 9 hnub los yog ntau dua Oxacillin nkag mus rau hauv ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg zoo li penicillin. Nrog / / cov lus qhia, cov ntsiab ntawm oxacillin hauv cov ntshav siab dua thaum noj ntawm qhov ncauj.

Siv nyob rau hauv / hauv lossis / m 2-3 g thiab siab dua 4-6 zaug ib hnub.

Ampicillin muaj qhov ntau ntawm cov kev ua, feem ntau yog microflora qhov tsis zoo yog qhov nkag siab nws. Cov tshuaj raug pov tseg los ntawm staphylococcal penicillinase, tab sis khaws cov kua qaub tsis kam thaum noj ntawm qhov ncauj. Los ntawm nws cov txiaj ntsig ntawm cov paj ntoo zoo-gram, nws tsis tshua muaj siab tshaj li penicillin, tab sis surpasses methicillin thiab oxacillin, tetracycline thiab chloramphenicol. Ampicillin nquag tshaj li ntawm tetracycline thiab chloramphenicol tiv thaiv hemophilic bacillus, protea, shigella, enterococci, ntxiv rau Escherichia coli. Cov nyhuv tshuaj tiv thaiv ntawm ampicillin yog ua kom zoo dua thaum ua ke nrog aminoglycosides thiab oxa-cillin. Txoj kev noj qab haus huv ntawm ampicillin thaum noj cov ncauj tawm ntawm 40 mus rau 60% thiab nyob ntawm qhov mob ntawm txoj hnyuv.

Raws li cov kinetics ntawm cov tshuaj (nws cov tsub zuj zuj hauv cov zis thiab cov kua tsib), nrog rau cov kab mob urogenital thiab cov kab mob hauv lub cev, kev siv cov tshuaj ampicillin sab hauv yuav tsum txiav txim siab txog cov qauv kev xaiv uas ua kom muaj kev ruaj khov nyob hauv cov ntshav. Thaum txhim kho txoj kev kho mob, nws yog ib qhov tsim nyog los sib piv cov ntsiab lus ntawm cov tshuaj tua kab mob hauv cov ntshav nrog MP / C qhov tseem ceeb rau cov xaiv kab mob. Ampicillin tsis muaj cov nyhuv nephrotoxic.

Rau kev kho mob los ntawm kev mob kis tsis yog-hemolytic streptococcus, pneumococcus, meningococcus thiab hemophilic bacillus, mob siab rau ampicillin, nws cov tshuaj lom hauv cov ntshav yuav tsis ntau dua 1 μg / ml, uas yog 2 g, tsawg dua 4 g ib hnub.

Cov qib siab dua ntawm cov tshuaj tau pom zoo zoo, yog tias tsis muaj kev txhim kho cov tshuaj lom nyob rau hauv 1-1.5 lub hlis thiab txawm tias ntev dua me ntsis. Lub sijhawm ntawm kev kho mob tau teeb tsa ib leeg zuj zus thiab txiav txim siab los ntawm daim ntawv thiab qhov loj ntawm tus kab mob.

Ampicillin (hauv tshuaj ntsiav lossis ntsiav tshuaj) yog muab qhov ncauj ntawm 0.5 g txhua 4-6 teev. Qhov koob tshuaj txhua hnub yog 2-4 g, s kis mob hnyav - nce txog 10 g lossis ntau dua. Nrog rau / / taw qhia - 0.5 g tom qab 4-6 teev, koob tshuaj txhua hnub yog 1-Zg.

Tsis tshua muaj tshuaj lom thiab tsis muaj qhov phom sij ntawm kev haus luam yeeb ntau tsim tau kev siv cov tshuaj ampicillin tsis muaj kev txwv tshwj xeeb hauv kev kho mob kis mob hauv cov xwm txheej ntawm lub raum tsis ua haujlwm. Txawm li cas los xij, kev kho qhov tseeb yog kho kom raug, txo qhov koob tshuaj lossis nce ntxiv ib ncua ntawm kev tswj hwm. Nrog rau cov pa nitrogen uas yog 80 mg, qhov koob tshuaj ntawm cov tshuaj tua kab mob txo mus rau 2/3, thiab ntau dua 80 mg% - txog 1/3 ntawm ib hnub.

Cov Txheej Txheem: Txoj kev tsis ua haujlwm, txo kom lub zog rau penicillin, mob raum tsis zoo.

• Raws li cov kab mob tiv thaiv kab mob ntawm kev ua, ampicillin ze rau Amoxicillin, tab sis nws cov haujlwm tiv thaiv cov kab mob rhiab yog 5-7 zaug siab dua. Cov tshuaj tua kab mob zoo yog nqus tau thaum noj qhov ncauj thiab muab faib rau hauv cov plab hnyuv siab raum thiab cov ntaub so ntswg.

Ib koob tshuaj amoxicillin yog 0.25-0.5 g rau kev tswj hwm qhov ncauj txhua 8 teev, rau cov menyuam, qhov koob tshuaj txhua hnub yog 20-40 mg / kg 3 zaug.

Thaum noj cov tshuaj sib npaug, cov tshuaj amoxicillin hauv cov ntshav siab txog 2 npaug ntau dua qhov kev nqus ntawm ampicillin. Tus pharmacokinetics ntawm cov tshuaj tsis hloov pauv nyob ntawm kev txais thiab cov sib xyaw ntawm cov zaub mov.

Sib piv cov yam ntxwv ntawm ampicillin thiab amoxacillin

Ntseg

Amoxicillin

Ampicillin

Dosage daim ntawv

Txog kev tswj hwm qhov ncauj

Txog ntawm ncauj thiab niam txiv kev tswj hwm

Kev mob plab zom mov (%)

Cov nyhuv ntawm kev ua noj

Tsis cuam tshuam dab tsi

Txo kev nqus

Tso zis zis

Siab heev

Siab

Kev sib xyaw hauv Sputum

Siab lossis tsis tu ncua

Ntshav lossis qes

Kev ua tawm tsam penicillin-resistant staphylococci

Sab sij huam

Me mob raws plab

Raws plab, tawm pob

Lub spectrum ntawm kev ua yog ze rau carbenicillin, piperacillin nquag ua haujlwm tiv thaiv Klebsiella, enterobacteria, Neisseria, hemophilic thiab Pseudomonas aeruginosa. Cov kab mob sib xyaw ua ke ntau ntawm Pseudomonas aeruginosa thiab cov kab mob nyob ze nws tseem yuav nkag tau rau piperacillin: nws cov haujlwm yog 8 npaug ntau dua li cov kev ua ntawm carbenicillin. Txawm li cas los xij, qhov kev nkag siab rau nws ntawm carbenicillin-resistant hom ntawm Pseudomonas aeruginosa yog qhov qis dua. Beta-lactamases ua los ntawm Staphylococcus aureus, thiab hom TEM, OXA, thiab CAPB ntawm cov kab mob gram-negative ua kom puas cov yeeb nkab ua yeeb yaj kiab. Nws yog qhov muaj zog heev rau qhov kev txiav txim ntawm cephalosporinases.

Piperacillin yog muab tshuaj rau hauv / hauv lossis / m. Nrog rau ntawm / hauv kev qhia ntawm bolus ntawm 2, 4, 6 g ntawm cov tshuaj tom qab 30 feeb, qhov siab tshaj plaws nyob rau hauv cov ntshav tau txiav txim siab - 300, 4U thiab 775 μg / ml, ntsig txog, nyob ruaj ruaj - 42 μg / ml. Nrog / / kev taw qhia, qhov siab tshaj plaws kuj tau mus txog tom qab 30 feeb, tab sis yog 40 μg / ml.

Nrog kev mob raum tsis ua haujlwm, T1 / 2 piperacillin nce ntxiv: nrog mob nrab - 2, nrog hnyav - 5-6 zaug. Hauv cov menyuam mos thiab cov neeg laus laus, T1 / 2 ua kom ntev, thiab qhov kev tshem tawm tag nrho tsawg. Nrog cov tshuaj protein, cov tshuaj khi rau 16-20%. Nws tau faib nyob rau hauv cov plab hnyuv siab raum thiab cov ntaub so ntswg, nrog rau lub siab, accumulates hauv bile hauv qhov siab (txog 3-4 μg / ml), nkag mus zoo los ntawm cov ntshav-hlwb teeb meem hauv cov neeg mob mob hlwb.

Qhov kev ua tau zoo ntawm piperacillin ua ke nrog lwm cov tshuaj tua kab mob hauv cov neeg mob uas mob txhab thiab neutropenia yog piv rau tias thaum siv cefotaxime thiab amikacin lossis moxolactam thiab amikacin. Hauv kev kho tshuaj monotherapy hauv kev kho mob ntawm cov kab mob ntawm cov kab mob loj heev, cov nyhuv ntawm piperacillin zoo nkaus li sib npaug ntawm ceftazidime.

Cov kev mob tshwm sim: thrombophlebitis (4%), hemorrhagic diathesis (17.2%), leukopenia (4%), eosinophilia (5-6%), mob siab rau hyper-fermentemia (2.3%).

Ampicillin Cov Qauv Qhia Txog

Cov tshuaj yeeb dej caw tseem ceeb yog qhov sib txuas ntawm tib lub npe. Ntxiv rau, lwm cov ntu pabcuam muaj nyob hauv qhov muaj pes tsawg leeg. Cov neeg tsim khoom yog cov tuam txhab Lavxias (piv txwv li, Synthesis).

Ampicillin thiab Amoxicillin muaj kev pom dav dav dav thiab kev tawm tsam ntau hom kab mob pathogenic.

Ntau daim ntawv tso tawm tau tsim:

Ntsiav tshuaj 1 daim muaj 0.25 g ntawm cov khoom xyaw dhia.
Cov tshuaj ntsiav Hauv 1 daim, 0.25 g ntawm cov khoom xyaw nquag yog tam sim no.
Kev Raug Ncua 5 ml muaj 0.25 g ntawm lub nquag sib txuas.

Ampicillin yog ib qho ntawm cov kab mob tua tau kab mob zoo tshaj plaws. Nws inhibits cov txheej txheem ntawm kev tsim cov phab ntsa ntawm cell qauv hauv cov kab mob. Cov tshuaj ua tawm tsam cov kab mob me uas koom nrog pab pawg cocci. Qhov no siv rau staphylococci, streptococci, gonococci, meningococci, pneumococci.

Cov tshuaj tawm tsam ntau cov kab mob gram-tsis zoo. Piv txwv, E. coli, enterobacteria, salmonella, thiab lwm yam. Tab sis qhov kev kho no tsis muaj txiaj ntsig rau hom kev ua penicillin, vim tias cov tshuaj ampicillin raug pov tseg los ntawm lawv cov kev ua.

Qhov ntau kawg ntawm cov kev ua haujlwm hauv cov ntshav yuav ua tiav hauv ob peb teev tom qab siv cov tshuaj. Ib nrab-lub neej nyob ntev li 2 teev. Cov tshuaj tawm hauv lub cev nrog bile thiab zis. Cov tshuaj pom tias yog tshuaj lom tsawg. Nws tsis sib sau hauv tib neeg lub cev. Vim qhov no, nws raug tso cai rau hauv cov khoom noj kom ntev ntev.

Ampicillin counteracts ntau cov kab mob gram-tsis zoo.

Cov tshuaj yog tawm rau kev kho mob ntawm kev kis mob uas rhiab rau ampicillin. Kev ntsuas rau kev siv muaj raws li nram no:

cov kab mob ntawm qhov mob ntawm thaj chaw qis ntawm cov kab mob ua pa, nrog rau cov kab mob ntawm lub qhov ntswg, qhov ncauj, mob ntsws, pob ntseg (siv rau kev mob ntsws, mob ntsws, tonsillitis, pharyngitis, sinusitis, otitis media, tonsillitis, mob khaub thuas),
urological pathologies nrog cov txheej txheem ua mob (qhov no suav nrog urethritis, cystitis, pyelonephritis, prostatitis, gonorrhea, thiab lwm yam),
cov kab mob gynecological los ntawm kev kis mob,
cov kab mob sib kis hauv cov kua tsib (siv rau cholangitis thiab cholecystitis),
cov kab mob pathological hauv txoj hnyuv (xws li cov kab mob xws li gastroenteritis, dysentery, enterocolitis, salmonellosis, mob typhoid, thiab lwm yam),
Cov mob ntawm daim tawv nqaij thiab cov nqaij mos tau raug mob los ntawm kev kis mob,
endocarditis
mob rwj
erysipelas,
caws pliav,
mob rau daim npluag qhwv
mob caj pas
sepsis.

Cov kev thaiv tsis zoo thiab cov tshwm sim

Ib leeg tsis qaug rau cov tshuaj txuas ntawm cov tshuaj. Cov neeg tsim khoom nco ntsoov tshwj xeeb hauv kev siv Amoxicillin, rau cov neeg muaj kev txom nyem kis mob hnyav ntawm lub siab thiab lub raum. Nws tsis pom zoo rau siv rau qhov kub thiab txias, ua daus no, nrog kev nce ntawm cov qog ntshav.

Siv thaum cev xeeb tub yog nqa tawm tshwj xeeb los ntawm kev saib xyuas ntawm kws kho mob.

Kev phiv tshuaj suav nrog kev ua xua, ua pob liab liab ntawm daim tawv nqaij, tawm pob, khaus, Quincke's edema. Cov cuab yeej tuaj yeem ua rau mob ntawm cov leeg ntawm lub qhov ntswg (rhinitis), mob ua ke lacrimation (mob caj dab), ua rau mob sib koom tes, hauv qee qhov tsis tshua muaj tshwm sim, ua rau anaphylactic poob siab.

Dab tsi tshwm sim ntawm ampicillin thiab amoxicillin?

Cov tshuaj ob qho no yog cov thawj coj tsis muaj tseeb hauv kev lag luam. Lawv tau pov thawj lawv tus kheej raws li txoj kev muaj txiaj ntsig ntawm kev sib txuas nrog ntau yam kabmob sib kis thiab cov kab mob me.

Lawv zwm rau tib pawg ntawm cov tshuaj tua kab mob nrog qhov ntau ntawm cov teebmeem, yog semi-hluavtaws campic pinicillins. Ob yam khoom muaj cov cim qhia tau zoo rau kev siv, yog yooj yim, pheej yig thiab yooj yim muaj.

Dab tsi yog qhov txawv?

Tag nrho qhov sib txawv ntawm Ampicillin thiab Amoxicillin yog keeb kwm tsim tshuaj yeebCov. Qhov tseeb yog tias Ampicillin tau tshawb pom ntau dhau los, thiab feem ntau cov kab mob me me muaj peev xwm hloov kho thiab txhim kho kev tiv thaiv cov tshuaj tiv thaiv no. Yog li, cov kws kho mob siv cov tshuaj Ampicillin tsawg dua thiab tsawg dua.

Lwm qhov txawv tshwj xeeb tshaj yog qhov pom dav dua ntawm cov teebmeem ntawm Amoxicillin ntawm cov kab mob muaj sia. Raws li hydroxyl pawg ntawm cov tshuaj yeeb tshuaj, cov tshuaj nkag mus rau cov ntshav sai dua, uas tso cai rau koj los ua kom muaj lub zog ntau dua ntawm cov tshuaj nquag hauv cov ntshav, muab cov nyhuv ua ke.

Raws li cov cwj pwm saum toj no, nws muaj kev nyab xeeb hais tias kev siv Amoxicillin yuav ua rau ntau dua. Nov yog tshuaj ntau dua, kev txais tos ntawm uas tau tso cai txawm tias cov menyuam yaus hnub nyoog qis dua ob xyoos. Amoxicillin tsis muaj qhov tseeb ntawm kev txwv tsis pub sib kis, muaj kev tiv thaiv zoo rau lub cev thiab tuaj yeem siv tau ob qho tib si hauv cov qauv tshuaj thiab ua rau kev txhaj tshuaj. Ib qho ntxiv, kev noj tshuaj Amoxicillin raug tso cai thaum cev xeeb tub thiab thaum pub mis.

Yog tias kev kho mob ntev, tom qab ntawd nws yog qhov zoo tshaj rau kev xaiv rau Amoxicillin. Nrog rau siv lub sijhawm ntev ntawm Ampicillin, kev txhim kho ntawm superinfection muaj peev xwm ua tau. Qhov tshwm sim no tshwm sim nyob rau hauv rooj plaub uas cov kab mob me me tsis teb rau qhov kev ua ntawm cov yeeb tshuaj, thiab nyob rau hauv qhov kev cuam tshuam ntawm ib puag ncig muaj kev txhoj puab heev, lawv pib tsim kev tiv thaiv kev tiv thaiv thiab nce rau ntawm qhov chaw siab, yog li txo qis ntawm lub cev tsis kam rau cov kab mob thaum pib.

Cov lus qhia rau siv Ampicillin thiab ntau npaum li cas

Ua ntej pib txoj kev kho, kev kuaj mob tsim nyog yuav tsum tau ua kom paub cov kab mob me me uas ua rau muaj tus kab mob thiab ntsuam xyuas rhiab rau ampicillin.

Cov koob tshuaj tau teeb tsa ib leeg zuj zus, suav txog qhov mob hnyav, qhov chaw nyob ntawm tus kab mob thiab qhov rhiab ntawm lub cev.

Cov ntsiav tshuaj thiab kev ncua yuav tsum tau noj ntawm qhov ncauj, ntxuav nrog dej, tsis hais qhov noj mov.

Koob tshuaj ib zaug rau cov neeg laus thaum noj ntawm qhov ncauj yog 250-500 mg. Qhov tshuaj txhua hnub yog 1-3 g. Koob siab tshaj plaws yog 4 g nyob rau ib hnub.

Cov koob tshuaj txhua hnub rau cov menyuam yaus yog 50-100 mg rau 1 kg ntawm lub cev qhov hnyav. Nrog lub cev qhov hnyav tsawg dua 20 kg, 12.5-25 mg rau 1 kg yog raug kho. Qhov koob tshuaj txhua hnub tau muab faib ua 4 koob.

Lub sijhawm ntawm cov chav kawm yog nyob ntawm qhov mob hnyav ntawm cov voos thiab cov txiaj ntsig ntawm txoj kev kho.

Kev npaj ntawm kev ncua - ntxiv dej rau hauv lub hwj rau hauv lub raj mis kom txog thaum txaus ntshai thiab co zoo. Qhov npaj ncua yuav tsum ruaj khov nyob rau chav tsev li 14 hnub. Ua ntej txhua qhov kev siv, kev ncua yuav tsum tau muab co. 5 ml ntawm qhov raug tshem tawm npaj (1 daus) muaj 250 mg ntawm ampicillin.

cov menyuam yug tshiab los ntawm 1 lub hlis - 150 mg / kg lub cev hnyav /,
txog 1 xyoos - raws li 100 mg / kg lub cev hnyav hauv ib hnub.,
los ntawm 1 txog 4 xyoo - 100-150 mg / kg ntawm lub cev hnyav ib hnub.,
cov menyuam yaus hnub nyoog 4 xyoos ntau dua tau sau ntawv 1-2 g ib hnub.

Qhov koob tshuaj txhua hnub tau muab faib ua 4-6 koob.

Lub sijhawm kho yog nyob ntawm qhov mob hnyav tshaj plaws (txij li 5-10 hnub txog 2-3 lub lis piam, thiab hauv kev kho mob ntev - rau ntau lub hlis).

Nrog rau cov niam txiv ntawm cov npliag dej intramuscular thiab tso dej ntws los yog txau, koob tshuaj rau cov neeg laus yog 250-500 mg. Qhov koob tshuaj txhua hnub yog 1-3 g. Yog tias muaj mob hnyav, cov koob tshuaj tau nce mus rau 10 g lossis ntau dua.

Rau cov menyuam mos hnub nyoog tshaj 1 hlis, ib koob tshuaj txhua hnub ntawm 100 mg rau 1 kg ntawm lub cev qhov hnyav. Cov menyuam ntawm lwm pawg hnub nyoog tau sau tseg 50 mg rau 1 kg. Yog tias muaj mob hnyav, cov koob tshuaj tau nce. Qhov koob tshuaj txhua hnub tau muab faib ua 4-6 hno txhua 4-6 teev. Lub sijhawm ntawm kev kho nrog kev txhaj tshuaj intramuscular yog 7-14 hnub, nrog cov leeg mob - 5-7 hnub. Raws li cov lus tim khawv ntawm tus neeg mob tuaj yeem hloov mus rau kev txhaj tshuaj intramuscular.

Txhawm rau npaj cov tshuaj rau txhaj tshuaj intramuscular, cov ntsiab lus ntawm lub thauv yog yaj rau 2 ml dej rau kev txhaj tshuaj.

Txhawm rau npaj cov tshuaj rau cov tshuaj tswj kav, ib koob tshuaj xwb (tsis pub ntau tshaj 2 g) yog yaj hauv 5-10 ml dej rau kev txhaj tshuaj lossis tshuaj isotonic sodium chloride tov.

Cov qhia yog nqa tawm maj mam rau 3-5 feeb (1-2 g rau 10-15 feeb). Yog tias ib koob tshuaj ntau dua 2 g, cov tshuaj tau muab tshuaj ntxaum ntxaws.

Sab sij huam

Ampicillin tej zaum yuav cuam tshuam nrog cov kev mob tshwm sim hauv qab no:

Kev ua xua tshwm sim nyob rau hauv daim ntawv ntawm: khaus, rhinitis, conjunctivitis, urticaria, exfoliative dermatitis, erythema multiforme exudative. Tsis tshua muaj neeg nyob hauv daim ntawv ntawm Quincke's edema thiab anaphylactic kev poob siab,
Kev mob plab zom mov: qhov ncauj qhuav, xeev siab, ntuav, mob hauv plab, raws plab, mob plab hnyuv, mob plab, mob plab, hloov pauv, saj,
Kev tshwm sim los ntawm kab mob siab hepatobiliary thiab mob siab: cholestatic jaundice,
Los ntawm lub hauv nruab nrab hauv lub paj hlwb: mob taub hau, mob hlwb, tshee, txhav (thaum siv ntau kawg).

Cov tshuaj tiv thaiv hauv zos yog ua tau nrog kev txhaj tshuaj intramuscular nyob rau hauv daim ntawv ntawm infiltrates, mob ntawm qhov chaw txhaj tshuaj.

Ampicillin yog sib kis hauv cov teeb meem hauv qab no:

nrog rau kev nkag siab raug rau penicillin, cephalosporin, carbapenem,
nrog lymphocytic leukemia, kis mob mononucleosis.

Nrog rau daim siab ua haujlwm, cov tshuaj siv nrog rau kev soj ntsuam tas li ntawm nws cov kev xav hauv cov ntshav ntshav. Thaum muaj xwm txheej ceev, nws yog siv rau mob ntsws asthma, ua npaws kub nyhiab thiab lwm yam kab mob ua xua.

Nrog faj seeb, Ampicillin yuav tsum noj nrog lub raum tsis ua haujlwm, cev xeeb tub, menyuam yaus hnub nyoog qis dua 1 hlis.

Cov tsos mob ntau dhau - ua rau pom kev cuam tshuam rau lub hauv nruab nrab lub paj hlwb (tshwj xeeb tshaj yog rau cov neeg mob raum tsis ua haujlwm), xeev siab, ntuav, raws plab, dej-electrolyte tsis txaus (ua rau ntuav thiab raws plab).

Kev Kho Mob - pais plab lav lav, ua kom hluav ncaig ntxiv, kua tshuaj laxa, tshuaj txhawm rau tswj cov dej-electrolyte sib npaug thiab cov tsos mob. Nws raug tawm los ntawm hemodialysis.

Ampicillin analogs, tus nqi hauv cov chaw muag tshuaj

Yog tias tsim nyog, koj tuaj yeem hloov Ampicillin nrog ib qho tshuaj tiv thaiv ntawm cov tshuaj nquag - cov no yog cov tshuaj:

Thaum xaiv cov tshuaj analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv ntawm Ampicillin, tus nqi thiab tshuaj xyuas cov tshuaj uas muaj cov teebmeem zoo sib xws tsis siv. Nws yog ib qho tseem ceeb kom kws kho mob sab laj thiab tsis txhob hloov pauv cov tshuaj ywj siab.

Tus nqi ntawm cov ntsiav tshuaj hauv cov khw muag tshuaj hauv Moscow los ntawm 19 rubles.

Txee lub neej yog 3 xyoos. Khaws rau hauv qhov chaw qhuav, tsaus ntawm qhov kub ntawm 15 ° C txog 25 ° C.

Ampicillin yog tshuaj tua kab mob ib nrab-hluavtaws uas muaj cov tshuaj tua kabmob thiab siv los kho ntau tus kabmob ntawm cov kabmob.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj Ampicillin muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tshuaj ntsiav thiab hmoov rau kev npaj ntawm kev ncua. Cov tshuaj ntsiav thiab cov tshuaj ntsiav yog tsim nyob rau hauv 0.25 g txhua qhov. Ib pob muaj 10 lossis 20 ntsiav tshuaj ntawm cov xim dawb nrog lub ntsej muag cylindrical. Cov tshuaj hauv daim ntawv ntawm hmoov muaj xim dawb nrog lub zas daj. Nws qab qab zib thiab muaj qhov tsw ntxhiab tsw. Lub hmoov muaj nyob rau hauv 60 ml txiv kab ntxwv lub khob hwj.

Txhua txhua daim ntawv ntawm Ampicillin, cov tshuaj ua kom nquag plias yog ampicillin trihydrate. Ib ntsiav tshuaj muaj 0.25 g ntawm cov tshuaj ua kom nquag plias, thiab ntxiv rau cov neeg tsis muaj zog nyob rau hauv daim ntawv ntawm cov hmoov txhuv nplej siab, talc, calcium stearate thiab magnesium stearate.

5 ml ntawm kev ncua raug npaj tau npaj siv Ampicillin hmoov muaj 125 mg ntawm ampicillin trihydrate thiab cov kev zam hauv qab no:

Silicon dioxide colloidal,
Sodium carboxymethyl cellulose,
Sodium citrate anhydrous,
Ponceau 4R (E124),
Sodium benzoate (E211),
Sucrose
Cherry qab.

Kev taw qhia txog kev siv Ampicillin

Raws li cov lus qhia rau Ampicillin, cov tshuaj no yog npaj rau kev kho mob ntawm ntau yam kab mob kis los ntawm microflora rhiab. Ntawm lawv yog cov kev sib kis kab mob hauv qab no ntawm txoj hnyuv:

Raws li cov lus qhia rau Ampicillin, cov tshuaj muaj txiaj ntsig ntawm kev muaj mob hnyav thiab mob nyhav ntawm cov zom zaub mov, genitourinary thiab mob plab, nrog rau cystitis, cholecystitis, pyelitis, salmonellosis thiab lwm yam.

Raws li cov lus qhia rau Ampicillin, cov tshuaj no kuj tau siv los kho cov kab mob hauv qab no:

Mob hauv pob ntseg, qhov ntswg thiab caj pas
Ua mob rau daim tawv nqaij
Cawv pliav,
Endocarditis
Cov tawv nqaij thiab cov nqaij mos sib kis kab mob,
Tso quav
Pob tsuas
Cov mob Odontogenic
Sepsis
Erysipelas
Gonorrhea

Kev noj tshuaj thiab kev tswj hwm ntawm Ampicillin

Ampicillin rau txhua daim foos yuav tsum tau noj li ib nrab teev lossis ib teev ua ntej noj mov. Cov ntau npaum li cas ntawm cov tshuaj tau tsim ib lub zuj zus rau txhua tus neeg mob, nyob ntawm qhov mob hnyav thiab daim ntawv ntawm tus kab mob, nrog rau kev coj mus rau hauv tus account qhov chaw ntawm tus kab mob thiab lub hnub nyoog ntawm tus neeg mob.

Ib koob tshuaj ib zaug hauv cov tshuaj rau hauv cov qauv ntawm cov ntsiav tshuaj rau cov neeg laus yog 250-500 mg. Qhov koob tshuaj txhua hnub yog 1-3 g. Rau cov menyuam yaus hnyav dua 20 kg, koob tshuaj txhua hnub ntawm Ampicillin yog 12,5-25 mg / kg, thiab rau cov menyuam yaus hnyav dua 20 kg nws yog 50-100 mg / kg. Raws li txoj cai, koob tshuaj txhua hnub ntawm lub tshuaj tau muab faib ua 4 koob.

Txhawm rau npaj qhov kev ncua, 62 ml dej rhaub tau muab nchuav rau hauv lub thauv nrog rau yeeb tshuaj thiab shaken kom huv si. Rau cov neeg mob laus, cov tshuaj Ampicillin ib txwm siv rau hauv cov hmoov yog 500 mg txhua 6 teev.

Feem ntau, suav nrog kev mob ntsws, mob ntsws, thiab ntau yam kabmob ntawm cov genitourinary huam thiab lub plab zom mov, noj ntau npaum 500 mg rau 4 zaug hauv ib hnub yog siv. Nrog tus kab mob gonorrhea, 2 g ntawm cov tshuaj feem ntau noj 1 zaug hauv ib hnub.

Hauv qee qhov kis mob, ntxiv cov koob tshuaj Ampicillin ntxiv ua ib qho kev ncua kev kawm yuav tsum tau ua. Yog tias lawv tshwm sim hauv daim ntawv hnyav, koob tshuaj rau cov neeg laus tuaj yeem yog 3 g ib hnub.

Qhov koob tshuaj txhua hnub ntawm Ampicillin hmoov rau cov menyuam yaus hnub nyoog qis dua 3 xyoos yog 100-200 mg / kg lub cev hnyav. Nws muab faib ua 4 koob. Rau cov menyuam yaus hnub nyoog ntau dua 3 xyoos, kev noj tshuaj yog raws li hauv qab no: 50-100 mg / kg lub cev hnyav, muab faib 4 zaug.

Phiv los ntawm Ampicillin

Kev siv cov tshuaj Ampicillin qee zaum tuaj yeem ua rau muaj kev phiv tshuaj nyob rau hauv daim ntawv ntawm kev ua xua. Ntawm lawv yog cov hauv qab no:

Quincke's edema,
Cov tawv nqaij ua pob thiab khaus,
Kab mob ntsws
Erythema multiforme,
Rhinitis
Exfoliative dermatitis,
Urticaria.

Muaj qee zaus, ampicillin tuaj yeem ua rau mob sib koom tes, anaphylactic shock, eosinophilia, thiab kub cev. Qee zaum cov tshuaj ua rau muaj kev phiv los ntawm cov zom zaub mov xws li xeev siab, ntuav, nce roj ntau hauv cov hnyuv thiab raws plab.

Kev siv cov tshuaj ampicillin tuaj yeem ua rau:

Stomatitis
Mob Kev Plab
Agranulocytosis,
Leukopenia
Nce kev ua ntawm hepatic transaminases,
Thrombocytopenia
Pseudomembranous mob plab,
Glossitis.

Kev kawm ntev nrog Ampicillin tuaj yeem ua rau superinfection hauv cov neeg mob uas tsis muaj zog. Tej qhov xwm txheej zoo li no, nws yog ib qho tsim nyog yuav tsum tau so kom noj cov vitamins.

Cov lus thiab cov xwm txheej ntawm kev cia

Ampicillin yuav tsum muab cia rau hauv qhov chaw tsaus thiab qhuav uas cov menyuam yaus nkag tsis tau, sov li chav sov. Lub txee lub neej rau tshuaj ntsiav thiab hmoov yog 3 xyoos, thiab rau cov ntsiav tshuaj - 2 xyoos.

Kws tsim tshuaj paus tam sim no muaj ntau txoj kev xaiv ntawm cov tshuaj bacteriostatic. Qee tus ntawm lawv muaj cov kev ua yeeb yam dav, lwm tus tsuas yog sib ntaus nrog qee yam kab mob me. Cov tshuaj zoo li no txwv tsis pub coj lawv tus kheej, vim hais tias qhov tshwm sim ntawm txoj kev kho tuaj yeem yuav sib txawv. Hnub no tsab xov xwm yuav qhia koj txog Ampicillin. Cov lus qhia rau kev siv, tshuaj xyuas, cov qauv (analogues) thiab tus qauv qhia kev siv raug yog coj los hais rau koj mloog.

Tam sim ntawv ua qhov tshwj tseg tias cov ntaub ntawv tau txais yuav tsum tsis txhob yos koj rau kev noj tshuaj koj tus kheej. Yog tias koj muaj teeb meem kev noj qab haus huv thiab xav tau cov tshuaj hnyav xws li tshuaj tua kab mob, koj yuav tsum nrhiav kev pab kho mob tiag tiag. Tsuas yog hauv qhov no muaj qhov muaj txoj hmoo kom rov zoo sai.

Cov lus qhia me ntsis ntawm Ampicillin

Cov khoom siv tseem ceeb yog ampicillin. Qhov no yog cov tshuaj tua kab mob kom dav-dav, uas muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj, tshuaj ntsiav, ncua kev kawm ntawv.

Cov cuab yeej thaiv kev tsim cov kab mob ntawm tes phab ntsa. Ntxiv mus, Ampicillin ua tau zoo tsuas yog tawm tsam cov kab mob me me los ntawm pawg cocci: staphylococci, gonococci, pneumococci. Tsis tas li ntawd, cov tshuaj pab nrog Escherichia coli, Salmonella, sib ntaus nrog lwm cov kab mob gram-tsis zoo.

Tab sis tib lub sijhawm, nws tsis muaj txiaj ntsig nrog penicillin-forming hom microorganisms, raug rhuav tshem raws li lawv txoj haujlwm.

Hauv 2-3 teev tom qab kev tswj hwm, qhov ntau kawg ntawm cov khoom sib txuam hauv lub cev tau mus txog. Lub sijhawm tshem tawm yog li 2 teev - cov tshuaj tawm hauv cov zis.

Cov tshuaj no yog suav hais tias yog tshuaj lom qis vim tias nws tsis nthuav tawm hauv lub cev. Yog li ntawd, nws raug tso cai kom coj nws hauv qhov ntau rau ntau lub lis piam kom nyab xeeb rau kev noj qab haus huv, raws li kev qhia.

Kev taw qhia rau kev siv:

mob ntsws o, tonsillitis, sinusitis, otitis media,
urethritis, pyelonephritis, kab mob gonorrhea,
cholecystitis
mob ncauj plab, salmonellosis,
rheumatism, caws pliav kub taub hau, sepsis.

Cov tshuaj tuaj yeem tsuas yog kho los ntawm tus kws kho mob uas txiav txim qhov tsuas noj, kev kho mob, suav nrog tus neeg mob lub hnub nyoog thiab keeb kwm kev kho mob. Nws yog tsis yooj yim sua kom ncaim ntawm kev kho mob raws li kev coj ua kom tsis txhob ua kom kabmob ntau dua.

Cov lus qhia me ntsis ntawm Amoxicillin

Amoxicillin yog ib qho tshuaj tua kab mob ntau yam uas tau muab kho rau kev kho mob ntawm cov kab mob los ntawm cov kab mob nkag rau nws.

Amoxicillin yog siv rau kev mob ntsws, mob ntsws, thiab mob rau daim tawv nqaij.

Cov cim tseem ceeb rau kev siv:

mob ntsws, mob ntsws,
kis kab mob ntawm daim tawv nqaij
cystitis, pyelonephritis,
kis txoj hnyuv pathologies.

Qee qhov xwm txheej, Amoxicillin raug kho raws li kev kho mob thaum lub sij hawm ntau cov txheej txheem kho mob hauv lub qhov ncauj kab noj hniav, kev tshem tawm ntawm Helicobacter Pylori. Txhawm rau txhim kho cov tshuaj, clavulanic acid tuaj yeem kho nyob rau tib lub sijhawm nrog kev noj tshuaj.

Muaj nyob hauv ntau hom: ntsiav tshuaj, tshuaj ntsiav, ncua kev kawm ntawv, muab daws rau kev tswj hwm ntawm cov leeg.

Cov nyhuv ntawm cov tshuaj tsuas yog cuam tshuam rau cov kab mob xwb - Amoxicillin tsis cuam tshuam rau cov kab mob fungus, kab mob. Tsis txhob siv cov tshuaj tua kab mob no rau kev mob khaub thuas, qhov no tuaj yeem ua rau kom muaj kev txhim kho ntawm tus kabmob tua.

Dab tsi yog qhov txawv

Thawj qhov sib txawv tseem ceeb yog cov tshuaj nquag. Yog li, nyob rau hauv muaj pes tsawg leeg ntawm Ampicillin muaj sodium ampicillin, hauv nws cov analogue - amoxicillin trihydrate. Tshuaj kuj sib txawv ntawm qhov kev phiv tshuaj. Rau cov tshuaj ampicillin, xeev siab, raws plab, dysbiosis, thiab kev loj hlob ntawm candidiasis yog yam ntxwv ntau dua.

Amoxicillin kuj tseem tuaj yeem muaj cov kev ua tsis haum, qhov kev loj hlob ntawm superinfection, uas yog tshwm sim los ntawm qhov nce ntxiv ntawm lwm cov kab mob me.

Dab tsi yog qhov zoo dua Ampicillin thiab Amoxicillin

Txhais tau tias nws zoo dua - koj ua tsis tau. Tsuas yog tus kws kho mob tuaj yeem sau tshuaj tua kab mob, nyob ntawm tus neeg mob tsis txaus siab, qhov tshwm sim ntawm nws kev sim. Tab sis feem ntau feem ntau hauv kev kho mob ntawm cov kab mob kis tau tshwm sim nyob rau hauv daim ntawv hnyav, nws raug nquahu kom noj Amoxicillin, ntxiv nrog clavulanic acid los txhim kho cov nyhuv.

Ampicillin nyiam dua yog siv los kho cov mob sib kis me.

Thaum cev xeeb tub thiab lactation, koj tuaj yeem noj tshuaj tsuas yog tom qab sab laj nrog kws kho mob yog tias cov txiaj ntsig rau leej niam dhau qhov ua raug mob rau lub plab lossis menyuam yaus. Thiab cov menyuam yaus txij thaum ntxov hnub nyoog tuaj yeem muab tshuaj Amoxicillin, muab qhov hnyav thiab hnub nyoog ntawm tus neeg mob.

Kuv puas tuaj yeem haus Amoxicillin hloov chaw ntawm Ampicillin?

Raws li cov tshuaj pharmacological, 2 ntawm cov neeg sawv cev no muaj cov qauv zoo sib xws. Vim li no, ntau tus kws kho mob tau sau ntawv yuav yog Ampicillin lossis Amoxicillin. Txawm li cas los xij, nws tsis tuaj yeem xaiv cov tshuaj thiab ua kev kho mob ntawm koj tus kheej - tsuas yog tus kws kho mob tuaj yeem ua qhov no.

Txawm li cas los xij, yog tias kev kho mob yuav tsum tau siv lub sijhawm ntev ntawm cov ntsiav tshuaj, Ampicillin raug kho vim tias nws qis dua bioactivity. Yog tias koj noj Amoxicillin ntau zaus, qhov no tuaj yeem ua rau muaj kev mob tshwm sim.

Yog tias koj hloov Amoxicillin nrog txoj kev kho zaum ob, tom qab ntawd vim tias kev siv tshuaj lom neeg tsawg, kev ua rau cov tshuaj hauv cov ntshav yuav tsis txaus. Hauv qhov no, tus kabmob tuaj yeem nkag mus rau theem ntev, tom qab ntawd kev kho mob hauv tsev kho mob yuav tsum tau kho.

Lub tswv yim ntawm cov kws kho mob thiab cov neeg mob tshuaj xyuas

Olga, 42 xyoo, kws kho mob

Txog kev kho mob ntawm ENT pathologies thiab mob plab hnyuv, Amoxicillin yog kho rau cov neeg mob. Cov cuab yeej siv tsis tau zoo, nws muaj kev sib ntaus sib tua zoo nrog ntau cov kab mob, muaj bioavailability siab, uas ua rau txo qis rau lub sijhawm kho mob thiab qhov nce ntxiv hauv kev ua haujlwm ntawm cov tshuaj. Feem ntau, tsis muaj kev phiv tshuaj dab tsi.

Irina, 35 xyoo, Moscow

Raws li qhov mob hypothermia hnyav, nws kis mob ntsws, thiab tus kab mob sai sai tau ua mob ntev. Tus kws kho mob tau sau Amoxicillin ua ib feem ntawm txoj kev kho kom ncaj. Tom qab 7 hnub, nws tau pib ua lub siab dua, hnoos thiab kub taub hau yuav luag ploj. Tom qab kho, tus kws kho mob qhia kom siv tshuaj tiv thaiv tshuaj tiv thaiv kab mob.

Elena, 24 xyoos, Perm

Kuv tau noj cov txiv hmab txiv ntoo tsis zoo, ua rau muaj kev lom vim kev mob plab hnyuv. Tau raug kho nrog Ampicillin 5 hnub. Lub sijhawm no, nws muaj peev xwm tshem tawm cov tsos mob. Kuv coj tshuaj tua kab mob tau zoo, tsis muaj kev phiv tshuaj.

Kev paub ua ntej: daim foos tso tawm, nqi thiab tsim

Cov tshuaj nquag siv ntawm cov tshuaj yog cov tshuaj sib txuas hu ua ampicillin trihydrate. Cov lus qhia ntawm cov tshuaj tua kab mob no yuav muaj qhov sib xyaw ua ke los yog sib txawv hauv cov khoom sib txawv. Koj yuav kawm txog lawv tom qab hauv tsab xov xwm. Ampicillin feem ntau muaj nyob hauv daim ntawv ntawm cov ntsiav tshuaj thiab hmoov. Qhov kawg yog npaj rau kev ua intramuscular lossis intravenous thawj coj. Kev daws yuav tsum xub tau npaj. Yuav ua li cas thiaj ua nws yog - piav qhia cov lus qhia hauv kev nthuav dav. Tsawg tsawg dua ntawm kev muag koj tuaj yeem nrhiav kev ncua.

Tus nqi ntawm cov tshuaj yog pheej yig. Ampicillin tau tshwm sim ntawm cov khw muag tshuaj tau ntev heev. Koj tuaj yeem yuav nws yam tsis muaj daim ntawv yuav tshuaj. Cov ntsiav tshuaj hauv qhov nyiaj ntawm 20 daim ntawm 250 milligrams yuav raug nqi koj li 20 rubles. Nyob ntawm cov khoom lag luam, tus nqi yuav hloov me me dua lossis nce dua. Koj tuaj yeem yuav lub raj mis nrog cov hmoov rau txhaj rau 15 rubles. Cov ntsiab lus ntawm ampicillin rau hauv cov thawv zoo li no yuav txawv: 200, 250, 500 thiab 1000 milligrams.

Ua li cas Ampicillin ua haujlwm?

Cov tshuaj "Ampicillin" yog hais txog cov tshuaj tua kab mob semisynthetic tiv thaiv kab mob ntawm cov tshuaj penicillin. Cov cuab yeej muaj qhov dav dav ntawm kev nqis tes ua, yog li ntawd, nws tau feem ntau kho rau cov neeg mob yam tsis muaj kev yaum ua ntej rau kev nkag siab. Cov tshuaj txwv tsis pub coj los ua ke ntawm ib hom kab mob, uas muaj cov kab mob bactericidal.

Cov tshuaj nquag muaj txiaj ntsig tawm tsam ntau cov kab mob aerobic, ob qho tib si gram-zoo thiab gram-tsis zoo.Qhov tshuaj nws muaj qhov rho tawm. Nws tsis muaj peev xwm ua kom tsis txhob muab ntau npaug ntawm cov kab mob uas tsim cov tshuaj penicillinase. Hmoov tsis muaj, ntau ntau ntawm cov tam sim no. Feem ntau cov kab mob me me no tau tsim los vim siv cov tshuaj tiv thaiv kab mob tsis haum. Qhov no ib zaug ntxiv ua pov thawj tias koj tuaj yeem tsis tau tus kheej noj tshuaj, tab sis koj yuav tsum hu rau cov kws kho mob kom pab.

Penicillin hloov chaw

Kuv tuaj yeem xaiv analogues ntawm Ampicillin ntawm kuv tus kheej? Txhua tus kws kho mob thiab cov neeg uas muaj kev kawm kho mob teb cov lus nug no yam tsis muaj tseeb: tsis yog. Qhov tseeb yog tias qee qhov hloov pauv muaj qhov ntsuas qhov nqaim ntawm qhov kev txiav txim siab; lawv tuaj yeem ua tsis tau zoo rau qee lub sijhawm. Yog tias vim li cas koj tsis tuaj yeem siv cov tshuaj Ampicillin, lub cim tshiab ntawm kev hloov kho tshiab lossis kev hloov kho qub dhau los yuav tsum raug pom zoo los ntawm kws kho mob.

Koj twb tau paub hais tias cov tshuaj no zwm rau hauv pawg penicillin. Yog li, lwm txoj kev xaiv tshuaj tau xaiv los ntawm nws. Yog tias peb tab tom tham txog cov tshuaj uas cov tshuaj ampicillin trihydrate, ces cov tshuaj hauv qab no tuaj yeem ua qhov txawv: Zetsil, Stanzacillin, Penodil, Purcillin, Pentrexil, thiab lwm yam. Nco qab tias cov tshuaj "Ampicillin" tuaj yeem tsim los ntawm cov tuam txhab sib txawv. Yog li, nws lub npe lag luam tseem tab tom hloov kho: "Ampicillin trihydrate", "Ampicillin sodium ntsev", "Ampecillin Innotek".

Koj tuaj yeem hloov lub cuab tam nrog tshuaj tua kab mob penicillin nrog lwm cov tshuaj uas cuam tshuam. Hauv qhov no, cov analogues ntawm Ampicillin yuav muaj cov kev ua hauv qab no:

amoxicillin (Augmentin, Ecobol, Flemoxin),
phenoxymethylpenicillin ("Clacil", "Ospen"),
oxacillin ("Prostaflin"),
piperacillin (Pizellin, Pipraks) thiab lwm yam.

Lwm txoj kev xaiv: tshuaj tua kab mob nrov

Analogues ntawm Ampicillin yuav muaj lwm yam tshuaj uas dhia. Cov no yog cov tshuaj muaj feem xyuam nrog lwm tus. Feem ntau lawv xaiv qhov hloov pauv thaum muaj qhov tsis haum tshuaj nyob hauv tus neeg mob. Qee cov tshuaj muaj feem rau cov tshuaj tiv thaiv tshiab. Yog li, cov cuab yeej "Ampicillin" analogues muaj cov hauv qab no.

Cephalosporins: Cefatoxime, Ceftriaxone, Suprax.
Macrolides: Sumamed, Vilprafen, Klacid.
Tetracyclines: Minolexin, Unidox, Tigacil.
Aminoglycosides: "Gentamicin", "Neomycin", "Streptomycin".
Lincosamides: Nerolen, Dalacin, thiab lwm yam.

Kev taw qhia txog kev siv thiab kev txwv txog kev siv Ampicillin

Kev tsis siv tshuaj tiv thaiv ntawm Ampicillin, zoo li cov tshuaj tua kab mob penicillin ua rau nws tus kheej, feem ntau muab tshuaj rau cov kab mob ntawm txoj hlab ua pa: mob ntsws, mob ntsws. Cov tshuaj no yog siv hauv ENT kev coj ua rau mob ntawm lub qhov ntswg, caj pas thiab pob ntseg. Nws yog tshuaj rau cov kab mob ua haujlwm ntawm lub plab zom mov, lub kaw lus genitourinary. Qhov qhia tau rau kev siv yog mob hlwb, mob sepsis, tawv nqaij mob, mob rheumatism.

Ua ntej siv cov tshuaj tua kab mob "Ampicillin", analogues lossis hloov pauv rau ib tiam tshiab, nws tseem ceeb nyeem cov lus qhia. Them nyiaj tshwj xeeb rau contraindications thiab kev phiv tshuaj. Yog li, piv txwv li, cov tshuaj "Ampicillin" tsis tuaj yeem siv nrog lub siab rhiab rau nws cov khoom, kev ua xua rau lwm yam kev sib kis tseem yuav ua rau kis mob mononucleosis, mob siab thiab ntshav. Cov tshuaj yog qhov tsis muaj txiaj ntsig tawm tsam kis kab mob.

Ampicillin: lus qhia rau siv

Cov tshuaj sib piv ntawm cov tshuaj ib txwm muaj kev sib txawv ntawm kev siv. Ua tib zoo saib rau qhov no. Kev siv tsis raug ntawm cov tshuaj tua kab mob ua rau muaj qhov tshwm sim tsis pom tshwm sim: los ntawm qhov tshuaj tsis txaus mus txog rau kev tuag. Koj twb paub hais tias Ampicillin muaj ob hom: ntsiav tshuaj thiab hno (koj tuaj yeem nrhiav kev ncua, tab sis nws tsis nrov heev). Yuav siv lawv li cas?

Tshuaj kho mob yog kws kho nyob hauv ib qho ntim ntawm 1 txog 2 gram ntawm cov tshuaj yeeb dej caw ib hnub (muab faib ua 4 zaug). Rau cov menyuam yaus, cov tshuaj raug tso tawm ua raws li qhov hnyav ntawm lub cev. Nws tsis pom zoo kom siv cov tshuaj los kho cov menyuam.
Nyob rau hauv daim ntawv ntawm kev txhaj tshuaj, cov tshuaj yog tawm rau cov neeg laus ntawm 250-500 mg txhua 4 lossis 6 teev (nyob ntawm tus mob thiab qhov mob hnyav). Rau kev kho mob ntawm cov menyuam yaus, "Ampicillin" yog siv rau hauv ntu ntawm 25 txog 50 mg ntawm tshuaj rau ib qhov hnyav ntawm lub cev. Nws yog ib qho tseem ceeb kom ceev faj thiab kev siv tshuaj aseptic thaum muab kev txhaj tshuaj.

Lub sijhawm kho mob yog txiav txim siab ntawm tus kheej, tab sis nws yuav tsum tsis pub tsawg dua tsib hnub. Qhov siab tshaj plaws txhua hnub rau cov neeg laus yog 4 grams hauv daim ntawv ntsiav tshuaj thiab 14 txhaj tshuaj.

Kev kho mob thaum cev xeeb tub thiab lactation

Qee yam tshuaj ntawm Ampicillin pub rau siv thaum lub cev xeeb tub, tab sis tsuas yog ua raws li kev qhia. Feem ntau, cov no yog cov tshuaj penicillin. Cov leej niam yav tom ntej yuav raug tshuaj macrolides, tab sis qhov no tsis tshua muaj. Cov tshuaj "Ampicillin" tuaj yeem siv thaum cev xeeb tub raws li kws kho mob tau qhia. Nws yog ib qho tsim nyog yuav tsum tsis txhob noj tshuaj tua kab mob tsuas yog nyob rau thawj lub hlis thib ib. Rau cov niam cev xeeb tub, cov tshuaj yog kws kho mob hauv ib tus neeg cov tshuaj raws li qee cov qauv.

Nws tau raug pov thawj pom tias cov tshuaj nquag - ampicillin trihydrate - tuaj yeem nkag mus rau hauv niam mis. Yog li ntawd, muaj ib lub caij nyoog uas cov tshuaj yuav nkag mus rau hauv tus menyuam lub cev. Yog tias xav tau kev kho mob thaum lub sijhawm lactation, koj yuav tsum txiav txim siab txog kev txiav kev pub mis niam.

Cov ntaub ntawv tshuaj ntxiv

Yog tias koj siv cov tshuaj Ampicillin analogue hauv cov tshuaj ua ke nrog cov tshuaj tua kab mob ua ntej, cov nyhuv ntawm ob qho tshuaj yuav nce ntau. Yog li, nws yog ib qho tseem ceeb kom xaiv txoj kev kho kom zoo. Tsis txhob xyaw nrog Ampicillin nrog cov tshuaj tua kab mob tshiab thiab lwm cov neeg ua haujlwm zoo sib xws uas muaj cov kab mob bactericidal.

Txij li thaum cov tshuaj suppresses lub plab hnyuv microflora, qhov no tuaj yeem ua rau ua txhaum ntawm cov zom zaub mov. Diuretics, sorbents thiab laxatives txo qhov nqus ntawm cov tshuaj tua kab mob. Ascorbic acid, nyob rau hauv sib piv, nce nws. Thov nco ntsoov tias cov tshuaj txo qis qhov ua tau zoo ntawm kev tshem tawm qhov ncauj.

Qhov cuam tshuam zoo ntawm kev kho

Cov tshuaj tsis siv rau cov tshuaj tua kab mob tshiab. Nws tsis mus los ntawm kev tu kom zoo. Yog li, cov tshuaj muaj peev xwm ua rau muaj ntau txoj kev tsis zoo. Ntawm lawv, cov feem ntau nquag:

kem plab, xeev siab, ntuav,
plab hnyuv dysbiosis, raws plab los yog cem quav,
fungal txhab ntawm qhov ncauj kab noj hniav, ntawm chaw mos, tawv nqaij,
kev ua xua nyob rau hauv daim ntawv ntawm edema, urticaria, poob siab.

Ua xua rau Ampicillin

Cov lus sib piv ntawm “Ampicillin” (hauv cov tshuaj los yog ntsiav tshuaj - nws tsis muaj qhov tseem ceeb) los ntawm pawg penicillin, zoo li cov tshuaj nws tus kheej, feem ntau ua rau muaj kev tsis haum. Txawm li cas los xij, nws tuaj yeem muaj ntau yam kev qhia. Yog tias koj tau mob ib ce dhau los, koj yuav tsum nco ntsoov. Yav tom ntej, thaum muab tshuaj rau tshuaj tua kab mob, nco ntsoov qhia qhov tseeb no rau tus kws kho mob.

Ua xua rau Ampicillin feem ntau yog ua pob tawm pob khaus rau ntawm daim tawv. Cov qhov ncauj tawm me me tuaj yeem nyob thoob plaws lub cev lossis hauv cov chaw sib cais. Cov cuab yeej tseem ua rau mob pob qij txha thiab ua nruj rau ntawm daim tawv nqaij. Tsawg dua qhov pom muaj o. Yog tias muaj qhov ua xua tshwm sim, koj yuav tsum sab laj nrog kws kho mob sai li sai tau, tsis txhob noj tshuaj ntxiv tom ntej. Txoj kev kho ntxiv yog koom nrog kev siv cov sorbents thiab antihistamines. Nws tseem yog qhov tsim nyog los xaiv ib qho tshuaj tiv thaiv ntawm cov tshuaj tua kab mob.

Ampicillin thiab dej cawv

Qhov kev qhia ntxiv hais txog tshuaj "Ampicillin" yog dab tsi? Kev ntsuas ntawm cov tshuaj penicillin, ntxiv rau cov tshuaj tua kab mob tau hais tseg, tsis pom zoo kom sib xyaw nrog cov dej cawv. Xws li kev sib xyaw ua ke ua kom muaj kev pheej hmoo ntawm cov kev mob tshwm sim. Tsis tas li ntawd, ethanol ua ke nrog Ampicillin cuam tshuam loj heev rau daim siab thiab lub plab. Kev sib xyaw ua ke ntawm cov tshuaj tuaj yeem tsuas yog ua kom cov nyhuv ntawm cov tshuaj.

Dua li ntawm qhov tseeb no, qee cov neeg siv khoom tswj tau hla ob peb tsom iav thaum kho. Cov neeg mob hais tias tsis muaj dab tsi tsis zoo tshwm sim rau lawv. Qhov tseeb, qhov no yog hmoov xwb. Tej zaum qhov tshwm sim yuav tseem tshwm rau lawv tus kheej yav tom ntej.

Broad-spectrum penicillin tshuaj tua kab mob, cuam tshuam los ntawm penicillinase

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Ntsiav tshuaj dawb, pav ca-cylindrical duab nrog chamfer thiab nqis siab tshaj.

Cov muaj mob siab tshaj: qos hmoov txhuv nplej siab, magnesium stearate, talc, polyvinylpyrrolidone, kaum-80.
10 Pcs - blister packs (1) - pob ntawv los ntawm cardboard.
10 Pcs - pob tsis muaj contour ntawm tes (1) - pob khoom los ntawm cardboard.

Hmoov rau kev tshem tawm ntawm qhov ncauj dawb nrog lub ringe daj lossis daj, nrog tus ntxhiab tsw tshwj xeeb, npaj tau muab tshem tawm ntawm dawb nrog lub tint daj.

Cov kev zam: polyvinylpyrrolidone, 1-aqueous sodium glutamate, disubstituted sodium phosphate lossis anhydrous disodium phosphate, Trilon B, dextrose, vanillin, cov khoom noj muaj ntxhiab tsw qab (raspberry), ua kom muaj suab thaj los yog qab zib.
60 g (5 g ntawm cov tshuaj muaj yees) - lub raj mis (1) ua tiav nrog ib rab diav tshuaj noj - pob khoom ntawm cardboard.

10 ml fwj (1) - pob khoom los ntawm cardboard.
10 ml fwj (10) - pob khoom los ntawm cardboard.
10 ml fwj (50) - thawv ntawv thawv.

Hmoov rau kev daws rau kev txhaj tshuaj dawb, hygroscopic.

Fwj nrog ntim ntawm 10 lossis 20 ml (1) - pob khoom los ntawm cov thawv ntawv.
Fwj nrog ntim ntawm 10 lossis 20 ml (10) - ntim ntawm cov duab los qhia.
10 lossis 20 ml fwj (50) - thawv ntawv thawv.

Pharmacological kev txiav txim

Antibiotic pawg pab pawg ntawm semisynthetic penicillins nrog rau kev pom dav. Nws muaj cov kab mob bactericidal los ntawm inhibiting qhov kev sib txuas ntawm cov kab mob ntawm tes phab ntsa.

Nquag tiv thaiv cov kab mob gram-zoo aerobic: Dab Tsi Staphylococcus spp. (nrog rau kev zam ntawm penicillinase ua cov leeg raug mob), Streptococcus spp. (suav nrog Enterococcus spp.), Listeria monocytogenes, Cov kab mob gram-negative aerobic: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, qee yam kab mob ntawm Haemophilus influenzae.

Nws raug rhuav tshem los ntawm penicillinase. Acid tiv taus.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, nws zoo tawm los ntawm txoj hnyuv plab, tsis rhuav tshem hauv lub chaw acidic ntawm lub plab. Tom qab kev tswj hwm hauv niam txiv (i / m thiab i / v) nws pom nyob hauv cov ntshav hauv qhov siab.

Nws nkag mus rau hauv cov ntaub so ntswg thiab lub cev ntawm lub cev, pom nyob rau hauv kev kho kom haum ntau hauv cov kua dej pleural, peritoneal thiab synovial. Cais tau los ntawm qhov tsis muaj teeb meem. Nws nkag mus rau qhov tsis zoo los ntawm kev tawm tsam cov ntshav-lub hlwb, txawm li cas los xij, nrog cov mob ntawm daim nyias nyias ntawm lub paj hlwb, qhov permeability ntawm BBB nce ntau.

30% ntawm ampicillin yog metabolized hauv lub siab.

T 1/2 - 1-1.5 teev .Thaum tshem tawm feem ntau nrog tso zis, thiab qhov ntau ntawm cov tshuaj tsis hloov pauv tau tsim hauv cov zis. Ib nrab tawm nrog nrog bile.

Nrog kev txhaj tshuaj ntxiv tsis mus ntxiv.

Cov kab mob sib kis thiab mob tau tshwm sim los ntawm cov kab mob me me rau cov tshuaj ampicillin, suav nrog:

- mob ntsws ua pa (nrog rau mob ntsws, mob ntsws, mob ntsws qhuav),

- kis mob ntawm tus mob ENT (nrog rau tonsillitis),

- biliary huam mob (nrog rau cholecystitis, cholangitis),

- mob txeeb zig (suav nrog pyelitis, pyelonephritis, cystitis),

- mob ncauj plab (nrog rau tus kab mob salmonella carriage),

- kis ntawm daim tawv nqaij thiab cov nqaij mos,

- sepsis, mob septic rau leeg,

Yeeb tshuaj sib cuam tshuam

Probenecid nrog rau kev siv ib txhij nrog Ampicillin-AKOS txo cov leeg tso pa ntawm ampicillin, vim tias nws cov ntsiab lus hauv nws cov ntshav plasma nce ntxiv thiab qhov phom sij ua rau lub cev muaj mob ntxiv.

Nrog rau kev siv Ampicillin-AKOS thooj txhij nrog kev nce pob ntawm daim tawv nqaij.

Nrog rau kev siv Ampicillin-AKOS thooj txhij, kev ua haujlwm ntawm cov tshuaj estrogen uas muaj qhov ncauj txwv tsis pub tsawg.

Nrog rau kev siv Ampicillin-AKOS ib txhij, cov hauj lwm zoo ntawm aminoglycoside kuj tseem nce ntxiv.

Cov lus qhia tshwj xeeb

Hauv kev kho mob nrog Ampicillin, yuav tsum saib xyuas lub siab thiab lub raum tas li. Yog tias lawv ua txhaum, cov tshuaj rau noj yuav tsum raug kho.

Kev txhaj tshuaj ntau hauv cov neeg mob uas lub raum tsis ua haujlwm tuaj yeem ua rau lub zog tsis haum rau hauv nruab nrab lub paj hlwb.

Ampicillin analogues

Ntawm cov analogues ntawm Ampicillin, cov tshuaj hauv qab no tuaj yeem ua qhov txawv:

Ampicillin-AKOS,
Ampicillin sodium ntsev,
Ampicillin-Ferein,
Puricillin
Zetsil
Standacillin,
Ntsuas.

Cov lus thiab cov xwm txheej ntawm kev cia

Kev paub ua ntej: daim foos tso tawm, nqi thiab tsim

Ua li cas Ampicillin ua haujlwm?

Cov tshuaj nquag muaj txiaj ntsig tawm tsam ntau cov kab mob aerobic, ob qho tib si gram-zoo thiab gram-tsis zoo. Qhov tshuaj nws muaj qhov rho tawm. Nws tsis muaj peev xwm ua kom tsis txhob muab ntau npaug ntawm cov kab mob uas tsim cov tshuaj penicillinase. Hmoov tsis muaj, ntau ntau ntawm cov tam sim no. Feem ntau cov kab mob me me no tau tsim los vim siv cov tshuaj tiv thaiv kab mob tsis haum. Qhov no ib zaug ntxiv ua pov thawj tias koj tsis tuaj yeem noj tshuaj rau koj tus kheej, tab sis koj yuav tsum hu rau cov kws kho mob kom pab.

Penicillin hloov chaw

Kuv puas tuaj yeem xaiv analogues ntawm Ampicillin ntawm kuv tus kheej? Txhua tus kws kho mob thiab cov neeg uas muaj kev kawm kho mob teb cov lus nug no yam tsis muaj dabtsi: tsis yog. Qhov tseeb yog tias qee qhov hloov pauv muaj qhov ntsuas qhov nqaim ntawm qhov kev txiav txim siab; lawv tuaj yeem ua tsis tau zoo nyob rau qee qhov xwm txheej. Yog tias vim li cas koj tsis tuaj yeem siv cov tshuaj Ampicillin, lub cim tshiab ntawm kev hloov kho tshiab los yog hloov chaw dhau los yuav tsum raug pom zoo los ntawm kws kho mob.

Koj twb tau paub hais tias cov tshuaj no zwm rau hauv pawg penicillin. Yog li, lwm txoj kev xaiv tshuaj tau xaiv los ntawm nws.Yog tias peb tab tom tham txog cov tshuaj uas cov tshuaj ampicillin trihydrate, ces cov tshuaj hauv qab no tuaj yeem ua qhov txawv: Zetsil, Stanzacillin, Penodil, Purcillin, Pentrexil, thiab lwm yam. Nco qab tias cov tshuaj "Ampicillin" tuaj yeem tsim los ntawm cov tuam txhab sib txawv. Yog li, nws lub npe lag luam tseem tab tom hloov kho: "Ampicillin trihydrate", "Ampicillin sodium ntsev", "Ampecillin Innotek".

Koj tuaj yeem hloov lub cuab tam nrog tshuaj tua kab mob penicillin nrog lwm cov tshuaj uas cuam tshuam. Hauv qhov no, cov analogues ntawm Ampicillin yuav muaj cov kev ua hauv qab no:

amoxicillin (Augmentin, Ecobol, Flemoxin),
phenoxymethylpenicillin ("Clacil", "Ospen"),
oxacillin ("Prostaflin"),
piperacillin (Pizellin, Pipraks) thiab lwm yam.

Lwm txoj kev xaiv: tshuaj tua kab mob nrov

Cephalosporins: Cefatoxime, Ceftriaxone, Suprax.
Macrolides: Sumamed, Vilprafen, Klacid.
Tetracyclines: Minolexin, Unidox, Tigacil.
Aminoglycosides: "Gentamicin", "Neomycin", "Streptomycin".
Lincosamides: Nerolen, Dalacin, thiab lwm yam.

Kev taw qhia txog kev siv thiab kev txwv txog kev siv Ampicillin

Ampicillin: lus qhia rau siv

Tshuaj kho mob yog kws kho nyob hauv ib qho ntim ntawm 1 txog 2 gram ntawm cov tshuaj yeeb dej caw ib hnub (muab faib ua 4 zaug). Rau cov menyuam yaus, cov tshuaj raug tso tawm ua raws li qhov hnyav ntawm lub cev. Nws tsis pom zoo kom siv cov tshuaj los kho cov menyuam.
Nyob rau hauv daim ntawv ntawm kev txhaj tshuaj, cov tshuaj yog tawm rau cov neeg laus ntawm 250-500 mg txhua 4 lossis 6 teev (nyob ntawm tus mob thiab qhov mob hnyav). Rau kev kho mob ntawm cov menyuam yaus, "Ampicillin" yog siv rau hauv ntu ntawm 25 txog 50 mg ntawm tshuaj rau ib qhov hnyav ntawm lub cev. Nws yog ib qho tseem ceeb kom ceev faj thiab kev siv tshuaj aseptic thaum muab kev txhaj tshuaj.

Kev kho mob thaum cev xeeb tub thiab lactation

Cov ntaub ntawv tshuaj ntxiv

Qhov cuam tshuam zoo ntawm kev kho

Cov tshuaj tsis siv rau cov tshuaj tua kab mob tshiab. Nws tsis mus los ntawm kev tu kom zoo. Yog li, cov tshuaj muaj peev xwm ua rau muaj ntau txoj kev tsis zoo. Ntawm lawv, cov feem ntau nquag:

kem plab, xeev siab, ntuav,
plab hnyuv dysbiosis, raws plab los yog cem quav,
fungal txhab ntawm qhov ncauj kab noj hniav, ntawm chaw mos, tawv nqaij,
kev ua xua nyob rau hauv daim ntawv ntawm edema, urticaria, poob siab.

Ua xua rau Ampicillin

Ampicillin thiab dej cawv

Broad-spectrum penicillin tshuaj tua kab mob, cuam tshuam los ntawm penicillinase

Yam khoom muaj sia

Ampicillin (nyob rau hauv trihydrate) (ampicillin)

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Ntsiav tshuaj dawb, pav ca-cylindrical duab nrog chamfer thiab nqis siab tshaj.

Hmoov rau kev tshem tawm ntawm qhov ncauj dawb nrog lub ringe daj lossis daj, nrog tus ntxhiab tsw tshwj xeeb, npaj tau muab tshem tawm ntawm dawb nrog lub tint daj.

10 ml fwj (1) - pob khoom los ntawm cardboard.
10 ml fwj (10) - pob khoom los ntawm cardboard.
10 ml fwj (50) - thawv ntawv thawv.

Hmoov rau kev daws rau kev txhaj tshuaj dawb, hygroscopic.

Fwj nrog ntim ntawm 10 lossis 20 ml (1) - pob khoom los ntawm cov thawv ntawv.
Fwj nrog ntim ntawm 10 lossis 20 ml (10) - ntim ntawm cov duab los qhia.
10 lossis 20 ml fwj (50) - thawv ntawv thawv.

Pharmacological kev txiav txim

Antibiotic pawg pab pawg ntawm semisynthetic penicillins nrog rau kev pom dav. Nws muaj cov kab mob bactericidal los ntawm inhibiting qhov kev sib txuas ntawm cov kab mob ntawm tes phab ntsa.

Nws raug rhuav tshem los ntawm penicillinase. Acid tiv taus.

Cov Tshuaj Pharmacokinetics

30% ntawm ampicillin yog metabolized hauv lub siab.

T 1/2 - 1-1.5 teev .Thaum tshem tawm feem ntau nrog tso zis, thiab qhov ntau ntawm cov tshuaj tsis hloov pauv tau tsim hauv cov zis. Ib nrab tawm nrog nrog bile.

Nrog kev txhaj tshuaj ntxiv tsis mus ntxiv.

Cov kab mob sib kis thiab mob tau tshwm sim los ntawm cov kab mob me me rau cov tshuaj ampicillin, suav nrog:

- mob ntsws ua pa (nrog rau mob ntsws, mob ntsws, mob ntsws qhuav),

- kis mob ntawm tus mob ENT (nrog rau tonsillitis),

- biliary huam mob (nrog rau cholecystitis, cholangitis),

- mob txeeb zig (suav nrog pyelitis, pyelonephritis, cystitis),

- mob ncauj plab (nrog rau tus kab mob salmonella carriage),

- kis ntawm daim tawv nqaij thiab cov nqaij mos,

- sepsis, mob septic rau leeg,

Cov Yuav Tsum Muaj

- Ua kom tsis haum rau cov tshuaj tua kab mob los ntawm pab pawg neeg penicillin thiab lwm yam tshuaj tua kab mob betalactam,

- Kev mob tsis zoo rau lub siab ua haujlwm (rau kev siv niam lossis txiv).

Teem ib tus zuj zus raws li qhov mob hnyav ntawm qhov kawg, qhov chaw muaj tus kab mob thiab qhov nkag siab ntawm lub cev.

Thaum noj ntawm qhov ncauj, ib koob tshuaj rau cov laus yog 250-500 mg, koob tshuaj txhua hnub yog 1-3 g. Koob siab tshaj plaws txhua hnub yog 4 g.

Rau menyuam cov tshuaj yog kws kho nyob rau hauv ib koob tshuaj txhua hnub 50-100 mg / kg, cov menyuam hnyav txog 20 kg - 12.5-25 mg / kg.

Qhov koob tshuaj txhua hnub tau muab faib ua 4 koob. Lub sijhawm kho yog nyob ntawm qhov mob hnyav thiab cov txiaj ntsig ntawm kev kho.

Cov ntsiav tshuaj tau noj ntawm qhov ncauj, tsis hais txog ntawm cov khoom noj.

Txhawm rau npaj qhov ncua kev kawm, 62 ml dej distilled ntxiv rau hmoov vial. Qhov xaus kev ncua yog dosed nrog ib rab diav tshwj xeeb uas muaj 2 daim paib: qhov qis ib qho sib raug rau 2.5 ml (125 mg), lub sab saud - 5 ml (250 mg). Qhov kev ncua yuav tsum tau muab ntxuav nrog dej.

Nrog rau cov kev tswj hwm hauv tsoomfwv (i / m, iv / dav hlau lossis iv nrog kua) ib qho tshuaj xwb rau cov laus yog 250-500 mg, qhov koob tshuaj txhua hnub yog 1-3 g, hauv kev kis kab mob hnyav, cov tshuaj txhua hnub tuaj yeem nce ntxiv txog 10 g lossis ntau dua.

Cov menyuam mos tshiab cov tshuaj yog tshuaj hauv ib hnub 100 mg / kg, cov menyuam ntawm lwm pawg hnub nyoog - 50 mg / kg. Hauv kev kis mob hnyav, cov koob tshuaj no tuaj yeem muab ob npaug.

Qhov koob tshuaj txhua hnub tau muab faib ua 4-6 koob nrog ib ncua sijhawm ntawm 4-6 teev Lub sijhawm ntawm lub sijhawm / m tswj yog 7-14 hnub. Lub sijhawm siv ntawm IV thov yog 5-7 hnub, tom qab ntawd hloov (yog tias tsim nyog) rau IM qhia.

Ib qho kev daws teeb meem rau kev tswj hwm intramuscular yog npaj los ntawm ntxiv 2 ml dej rau kev txhaj tshuaj rau cov ntsiab lus ntawm lub vial.

Txog rau kev txhaj tshuaj iv, ib koob ntawm cov tshuaj (tsis ntau tshaj 2 g) yog yaj hauv 5-10 ml dej rau kev txhaj tshuaj lossis cov tshuaj isotonic thiab maj mam muab li 3-5 feeb (1-2 g rau 10-15 feeb). Ntawm ib koob tshuaj ntau tshaj 2 g, cov tshuaj yog muab tshuaj kom tso ntshav. Txhawm rau ua qhov no, ib koob tshuaj (2-4 g) yog yaj hauv 7.5-15 ml dej rau kev txhaj tshuaj, tom qab ntawd cov txiaj ntsig tau ntxiv rau 125-250 ml ntawm cov tshuaj isotonic ntawm sodium chloride lossis 5-10% kev daws thiab txhaj rau qhov ceev ntawm 60-80 tee / min Nrog iv kua tsib rau hauv cov menyuam yaus, 5-10% kua nplaum tov (30-50 ml raws li hnub nyoog) yog siv ua tshuaj hnyav.

Cov kev daws teeb meem tau siv tam sim tom qab kev npaj.

Sab sij huam

Kev tsis haum tshuaj: daim tawv nqaij ua pob, urticaria, Quincke's edema, mob pruritus, exfoliative dermatitis, erythema multiforme, nyob rau hauv cov xwm txheej tsis tshua muaj mob - anaphylactic shock.

Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, glossitis, stomatitis, pseudomembranous colitis, plab hnyuv dysbiosis, kev ua si ntau ntawm hepatic transaminases.

Los ntawm cov kab ke hemopoietic: anemia, leukopenia, thrombocytopenia, agranulocytosis.

Qhov teebmeem vim kev siv tshuaj kho mob: qhov ncauj candidiasis, qhov chaw mos candidiasis.

Noj ntau dhau

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv Ampicillin-AKOS thooj txhij nrog kev nce pob ntawm daim tawv nqaij.

Nrog rau kev siv Ampicillin-AKOS thooj txhij, kev ua haujlwm ntawm cov tshuaj estrogen uas muaj qhov ncauj txwv tsis pub tsawg.

Nrog rau kev siv Ampicillin-AKOS ib txhij, cov hauj lwm zoo ntawm aminoglycoside kuj tseem nce ntxiv.

Cov lus qhia tshwj xeeb

Nrog ceev faj thiab tiv thaiv keeb kwm yav dhau los ntawm cov tib neeg siv cov tshuaj tiv thaiv kab mob sib kis, ib qho tshuaj yuav tsum tau tsim rau tus mob ntsws asthma, ua npaws thiab lwm yam kab mob ua xua.

Hauv kev siv los ntawm Ampicillin-AKOS, kev saib xyuas ib qho kev kaw lus ntawm lub raum, daim siab thiab ntu daim duab ntshav yog qhov tsim nyog.

Hauv kev ua haujlwm ntawm daim siab ua haujlwm, cov tshuaj yuav tsum tsuas yog siv los ntawm kev tswj daim siab kev ua haujlwm.

Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum tau kho cov tshuaj ntau npaum li cas nyob ntawm QC.

Thaum siv cov tshuaj hauv cov koob tshuaj siab hauv cov neeg mob lub raum tsis ua haujlwm, yuav ua rau muaj kev phiv rau hauv nruab nrab lub paj hlwb tau.

Thaum siv tshuaj yaj yeeb rau kev kho mob sepsis, muaj cov tshuaj tiv thaiv bacteriolysis tuaj yeem ua tiav (Yarish-Herxheimer cov tshuaj tiv thaiv).

Yog tias muaj qhov tsis haum tshwm sim thaum siv Ampicillin-AKOS, kev siv tshuaj yuav tsum raug txiav tawm thiab kev kho kom tsis muaj zog yuav tsum yog cov kws kho mob.

Cov neeg mob ua kom qaug zog nrog kev siv tshuaj ntev ntev yuav tsim kev saib xyuas los ntawm cov kab mob me me tawm tsam ampicillin.

Txhawm rau tiv thaiv qhov kev loj hlob ntawm candidiasis ib txhij nrog Ampicillin-AKOS, nystatin lossis levorin yuav tsum tau sau tseg, nrog rau cov vitamins ntawm pab pawg B thiab C.

Cev xeeb tub thiab lactation

Nws yog qhov ua tau los siv cov tshuaj thaum cev xeeb tub raws li kev qhia nyob rau hauv cov xwm txheej ntawd thaum cov txiaj ntsig rau leej niam outweighs qhov kev pheej hmoo rau tus me nyuam hauv plab.

Ampicillin ua rau cov kua mis tsis muaj mob ntau. Yog tias tsim nyog, kev siv cov tshuaj thaum lactation yuav tsum txiav txim siab txog kev txiav kev pub niam mis.

Nrog lub siab ua haujlwm tsis zoo

Kev siv niam txiv yog qhov sib cuam tshuam hauv txoj kev ua haujlwm hauv lub siab.

Cov lus thiab cov xwm txheej ntawm kev cia

Sau npe B. Cov tshuaj yuav tsum khaws cia rau hauv qhov chaw qhuav, tsaus nti, ntsiav tshuaj thiab hmoov rau kev ncua - ntawm qhov kub txog 15 ° txog 25 ° C, hmoov rau kev daws rau kev txhaj tshuaj - ntawm qhov kub tsis tshaj 20 ° C. Lub txee lub neej ntawm cov ntsiav tshuaj, hmoov rau kev ncua thiab hmoov rau kev daws rau kev txhaj tshuaj yog 2 xyoos.

Qhov npaj ncua yuav tsum muab khaws cia rau hauv tub yees lossis ntawm chav tsev tsis ntev tshaj 8 hnub. Cov kev npaj daws teeb meem rau i / m thiab iv kev tswj hwm tsis raug rau cia.

Cov Cai Siv Tshuaj So

Cov tshuaj yog ntawv yuav tshuaj.

Cov lus qhia rau kev siv. Cov txheej txheem sib khi thiab daim ntawv tso tawm.

Ib qho tshuaj tua kab mob ntau yam los ntawm pab pawg ntawm semisynthetic penicillins. Nws ua cov kab mob bactericidal, inhibiting qhov kev coj los ua ke ntawm cov kab mob cell cell. Nquag tiv thaiv cov kab mob gram-zoo: cocci - Staphylococcus spp. (nrog rau kev zam ntawm penicillinase ua cov leeg raug mob), Streptococcus spp. (suav nrog Enterococcus), kab mob sib kis tsis muaj kabmob - aerobic tsis muaj tus kabmob - Listeria monocytogenes. Ampicillin tseem ua haujlwm tawm tsam cov kab mob gram-negative: aerobic - Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, qee yam kab mob ntawm Haemophilus influenzae. Ampicillin raug pov tseg los ntawm penicillinase. Acid tiv taus.

Tom qab lub qhov ncauj tswj hwm, nws zoo tawm los ntawm cov hnyuv. Ampicillin muab faib rau hauv feem ntau cov plab hnyuv siab raum thiab cov ntaub so ntswg. Nws txhawm rau tso cov txiaj ntsig, tsis zoo rau lub cev BBB. Nrog kev mob rau ntawm daim npluag qhwv, permeability ntawm BBB nce ntau. 30% ntawm ampicillin yog metabolized hauv lub siab. Nws tawm hauv cov zis thiab kua tsib.

Cov kab mob sib kis thiab mob kis tau los ntawm cov kab mob me me nkag siab rau ampicillin: incl. kev kis mob ntawm pob ntseg, caj pas, qhov ntswg, kev kis tus kab mob, kev tiv thaiv kab mob ntsws, mob ntsws, mob ntsws thiab mob mus ntev ntawm cov kab mob genitourinary, mob rau lub plab, (nrog rau salmonellosis, cholecystitis), cov kab mob gynecological, kab mob rau daim tawv, endocarditis, septicemia, sepsis, rheumatism, erysipelas, scarlet fever, kis tau ntawm daim tawv nqaij thiab cov nqaij mos.

Teem ib tus zuj zus raws li qhov mob hnyav ntawm qhov kawg, qhov chaw muaj tus kab mob thiab qhov nkag siab ntawm lub cev.
Thaum noj ntawm qhov ncauj rau cov laus, ib koob tshuaj yog 250-500 mg, qhov ntau zaus ntawm kev tswj hwm yog 4 zaug / hnub. Cov menyuam yaus uas lub cev hnyav txog 20 kg tau xaj 12,5-25 mg / kg txhua 6 teev.
Txog kev siv tshuaj intramuscular, tso ntshav tshuaj, ib koob rau cov neeg laus yog 250-500 mg txhua 4-6 teev. Rau cov menyuam yaus, ib koob tshuaj tsuas yog 25-50 mg / kg.
Lub sijhawm tiv thaiv yog nyob ntawm thaj chaw ntawm kev kis tus kabmob thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob.
Cov koob tshuaj ntau tshaj: rau cov neeg laus, koob tshuaj txhua hnub rau kev tswj hwm ntawm qhov ncauj yog 4 g, koob tshuaj txhua hnub rau i / v thiab / m tswj hwm yog 14 g.

Kev tsis haum tshuaj: urticaria, erythema, Quincke's edema, rhinitis, pom mob, tsis tshua muaj - kub ib ce, mob pob txha, eosinophilia, tsis tshua muaj mob - anaphylactic shock.
Los ntawm lub plab zom mov: xeev siab, ntuav, mob plab hnyuv dysbiosis, mob plab los ntawm C. difficale.
Qhov cuam tshuam vim kev siv tshuaj kho mob: candidiasis ntawm lub qhov ncauj kab noj hniav, qhov chaw mos candidiasis.

Cov tshuaj tiv thaiv tsis haum rau cov tshuaj ampicillin thiab lwm yam penicillins, ua rau lub siab ua haujlwm tsis zoo.

Cev xeeb tub thiab lactation

Tej zaum yuav siv cov tshuaj ampicillin thaum cev xeeb tub raws li kev qhia. Ampicillin ua rau cov kua mis tsis muaj mob ntau. Yog tias tsim nyog, kev siv cov tshuaj ampicillin thaum lactation yuav tsum txiav txim siab txog kev txiav kev pub mis niam.

Hauv cov txheej txheem ntawm kev kho mob nrog cov tshuaj ampicillin, kev saib xyuas ib qho kev muaj txiaj ntsig ntawm kev ua haujlwm ntawm lub raum, daim siab thiab peripheral ntshav duab yog qhov tsim nyog. Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum tau kho cov tshuaj noj raws li QC cov nuj nqis.
Thaum siv cov koob tshuaj ntau hauv cov neeg mob lub raum tsis ua haujlwm, cov tshuaj lom rau hauv lub hauv nruab nrab lub paj hlwb yog qhov ua tau.
Thaum cov tshuaj ampicillin siv rau hauv cov neeg mob bacteremia (sepsis), kev siv tshuaj tiv thaiv bacteriolysis (Yarish-Herxheimer cov tshuaj tiv thaiv) yog ua tau.

Probenecid nrog rau kev siv ua ke nrog ampicillin txo cov tubular tso pa tawm ntawm qhov tom kawg, uas ua rau muaj qhov nce ntawm ampicillin hauv cov ntshav plasma thiab muaj kev pheej hmoo ntau ntxiv ntawm cov tshuaj lom.
Nrog rau kev siv cov tshuaj ampicillin sib xyaw nrog cov tshuaj estrogen uas muaj qhov ncauj, muaj qhov txo qis hauv lawv cov txiaj ntsig, tej zaum vim qhov ua rau tsis muaj zog ntawm cov hepatic ncig ntawm estrogens.

Cia rau lub sijhawm thiab qhov ntev cia Khw rau hauv qhov chaw qhuav, tsaus, ntsiav tshuaj thiab hmoov rau kev npaj ncua kev kawm - ntawm qhov kub txog 15 ° txog 25 ° C, hmoov rau kev daws rau kev txhaj tshuaj - ntawm qhov kub tsis tshaj 20 ° C.

Txee lub neej yog 2 xyoos.
Qhov npaj ncua yuav tsum muab khaws cia rau hauv tub yees lossis ntawm chav tsev tsis ntev tshaj 8 hnub. Cov kev npaj daws teeb meem rau i / m thiab iv kev tswj hwm tsis raug rau cia.