Tsifran OD (ODifran OD)

Cov Tshuaj Hauv Tshuaj Ciprofloxacin nquag plias hauv vitro qhov muaj ntau ntawm cov kab mob gram-negative thiab kab mob gram-zoo. Cov kab mob ua haujlwm ntawm ciprofloxacin yog qhov tshwm sim ntawm kev txwv tsis pub muaj cov enzymes topoisomerase II (DNA gyrase) thiab cov tshuaj topoisomerase IV, uas tsim nyog rau kev rov ua dua, hloov pauv, kho, thiab rov tso cov kab mob DNA. Cov txheej txheem ntawm kev ua ntawm fluoroquinolones, suav nrog ciprofloxacin, txawv ntawm cov txheej txheem ntawm kev ua ntawm penicillins, cephalosporins, aminoglycosides, macrolides thiab tetracyclines. Yog li, cov kab mob me me tiv taus cov chav kawm ntawm cov tshuaj no tej zaum yuav nkag siab ciprofloxacin thiab lwm yam quinolones. Tsis muaj qhov paub tias tus ntoo khaub lig-tiv thaiv ntawm ciprofloxacin thiab lwm chav kawm ntawm cov tshuaj tua kab mob. Kev Tawm Tsam hauv vitro rau ciprofloxacin kev loj hlob qeeb. Ciprofloxacin nquag tawm tsam txhua yam ntawm cov kab mob hauv qab no hauv vitrohauv kev kuaj mob,
aerobic gram-cov kab mob zoo: Cov kab mob Enterococcus faecalis (ntau yam kab mob tau yoog), Staphylococcus aureus (MSSA), Staphylococcus epidermidis (MSSA), Staphylococcus saprophyticus, Streptococcus pneumoniae (PSSP), Streptococcus pyogenes,
aerobic gram-cov kab mob tsis zoo: Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Straissergioerioerius geriomerierererioerioerioerioerioerioerioerioierer , Serratia marcescens, Shigella sonnei, Shigella boydii, Shigella dysenteriae, Shigella flexneri.
Ciprofloxacin kuj tseem ua haujlwm hauv vitro thiab los ntawm kev thov ib tus neeg surrogate marker txheeb ze rau Bacillus anthracis. Ciprofloxacin muaj hauv vitro yam tsawg kawg nkaus inhibitory concentration (MIC) ≤1 μg / ml cuam tshuam nrog feem ntau (90%) hom ntawm cov kab mob hauv qab no:
aerobic gram-cov kab mob zoo: Staphylococcus haemolyticus, Staphylococcus hominis, Streptococcus pneumoniae (PRSP),
aerobic gram-cov kab mob tsis zoo: Acinetobacter iwoffi, Pasteurella multocida, Aeromonas hydrophila, Salmonella enteritidis, Edwardsiella tarda, Vibrio Cholerae, Enterobacter aerogenes, Vibrio parahaemolyticus, Klebsiella oxytoca, Vibrio vulnificus, Legionellainophocolila.
Feem ntau cov leeg Burkholderia cepacia thiab tej leeg ntshav Stenotrophomonas maltophilia muaj kev tawm tsam rau ciprofloxacin, zoo li feem ntau cov kab mob anaerobic, suav nrog Bacteroides fragilis thiab Clostridium difficile.
Cov Tshuaj Pharmacokinetics Muaj peev xwm-tso cov ntsiav tshuaj ciprofloxacin yog tsim los kom cov tshuaj tso tawm qeeb qeeb dua li cov ntsiav tshuaj tam sim ntawd-tso tawm. Muaj peev xwm tso tau cov ntsiav tshuaj ciprofloxacin thiab cov ntsiav tshuaj tso tawm sai sai ciprofloxacin tsis hloov pauv. Cov ntaub ntawv pharmacokinetic ntawm ciprofloxacin txhawb nqa-ntsiav tshuaj ntawm 500 thiab 1000 mg thaum noj ib zaug ib hnub zoo ib yam li 250 thiab 500 mg ntsiav tshuaj nrog kev tso tawm sai sai thaum noj 2 zaug hauv ib hnub raws li AUC rau 24-teev sijhawm.
Qhov ntim ntawm qhov faib rau iv ncau ciprofloxacin yog kwv yees li 2.1-2.7 l / kg lub cev hnyav. Cov txiaj ntsig ntawm kev tshawb nrhiav nrog qhov ncauj thiab / hauv kev siv ciprofloxacin, qhia tau tias, nyob ntawm tus qauv ntawm kev siv, cov tshuaj nkag mus rau cov nqaij sib txawv. Kev khi ntawm ciprofloxacin nrog cov ntshiab protein yog 20-40%. 4 cov tshuaj tiv thaiv kab mob hauv cov zis tau sau tseg. Cov metabolites no muaj tsawg tshaj tawm ua si antimicrobial dua li tsis hloov pauv ciprofloxacin. Kev txo tawm ntawm cov metabolites no tshwm sim yuav luag tsis pub dhau 24 teev tom qab kev thov ntawm cov tshuaj. Qhov ua tau-tso tawm cov keeb kwm ntawm ciprofloxacin zoo ib yam li cov tshuaj tam sim ntawv tso ciprofloxacin. Kwv yees li 35% ntawm qhov ncauj noj tau tawm hauv cov zis tsis hloov pauv. Kev tso zis tawm tshwm sim yuav luag tag nrho hauv 24 teev tom qab siv cov tshuaj. Kwv yees li 20-35% ntawm qhov ncauj noj ntawm ciprofloxacin tam sim ntawd tso tawm hauv cov quav rau 5 hnub. Hauv cov neeg mob uas ua kom lub raum txo qis, ib nrab-lub neej ntawm ciprofloxacin yog lub sijhawm ntev me ntsis.

Dosage daim ntawv

zaj duab xis-txheej pab-tso ntsiav tshuaj.

txhua daim ntawv tso tawm cov ntsiav tshuaj-txheej txheem muaj: Cyfran OD 500 mg
Cov tshuaj kom nquag: ciprofloxacin - 500 mg. Tsifran OD 1000 mg
Cov tshuaj kom nquag: ciprofloxacin - 1000 mg.
Cov muaj mob: sodium alginate (Keltone LVCR), hypromellose, sodium bicarbonate, crospovidone (CLM), magnesium stearate, colloidal silicon dioxide (200), talc.

Xau zaj duab xis:
Opadry dawb 31B58910, talcum hmoov, hypromellose, cov dej lim dej, tus cwj mem dub rau cov ntawv sau (Opakod -S-1-17823 dub).
muaj pes tsawg leeg opadra dawb 31B58910: hypromellose, lactose, titanium dioxide, macrogol 400, evaporates thaum ntau lawm,
cov lus muaj xws li: shellac 45% (20% esterified) hauv ethanol, isopropanol, n-butanol, propylene glycol, aqueous ammonia 28%, dub hlau zas.

Daim ntawv tso tawm

Cov ntsiav tshuaj siv tau ntev ntev, zaj duab xis-coated 500 mg, 1000 mg. 5 ntsiav tshuaj ib lub hlwv, suav nrog aluminium ntawv ci ntawm ib sab thiab txhuas ntawv ci coated nrog polyamide zaj duab xis thiab PVC zaj duab xis ntawm qhov tod tes, 1 lossis 2 lub hlwv rau hauv daim npav thawv nrog cov lus qhia rau kev siv.

Ntsiav tshuaj "Tsifran OD 500 mg"
Cov ntsiav tshuaj zoo li dawb, los ntawm dawb mus rau yuav luag dawb, zaj duab xis-txheej, ntawm ib qho
ob sab ntawm lub ntsiav tshuaj zaub mov luam tawm "Cifran OD 500MG".

Hom ntsiav tshuaj thaum so:
nias loj los ntawm dawb mus rau yuav luag dawb.

Ntsiav tshuaj "Tsifran OD 1000 mg"
Cov ntsiav tshuaj zoo li dawb, los ntawm cov xim dawb mus yuav luag dawb, zaj duab xis-coated, “Cifran OD 1000MG” yog luam tawm ntawm ib sab ntawm lub ntsiav tshuaj nrog cov kua zaub mov.
Hom ntsiav tshuaj ntawm so: nias loj los ntawm dawb mus rau yuav luag dawb.

Lub Npe Tsis Muaj Npe International

Lub npe lag luam rau cov tshuaj no yog Cifran®. Lub npe txawv tebchaws tsis raug cai yog Ciprofloxacin (Ciprofloxacin). Hauv Latin - Ciprofloxacinum.

Ciphran nquag ua hauj lwm tiv thaiv feem ntau cov kab mob bacteriophages thiab cov kab mob ntawm cov kab mob pathogenic.

J01MA02 Cov tshuaj tiv thaiv tsis muaj zog.

Pharmacological kev txiav txim

Ciphran nquag tiv thaiv feem ntau cov kab mob bacteriophages thiab cov kab mob ntawm cov kab mob pathogenic tiv taus aminoglycosides. Yog li, cov kws paub txog kev noj qab haus huv pom zoo cov tshuaj no los tawm tsam sib xyaw ua ke los ntawm kev ua kom mob, ua kom muaj kab mob hu ua aerobic thiab mob plab hnyuv. Cov nyhuv bactericidal ntawm ciprofloxacin yog vim muaj peev xwm los tiv thaiv qhov kev tawm tsam ntawm cov enzymes uas tsim nyog rau lub neej ntawm microorganism.

Cov kws kho mob pom zoo kom Cifran tua cov kab mob sib xyaw ua ke.

Cov Tshuaj Pharmacokinetics

Nws nqus tau nrawm los ntawm qhov kawg ntawm txoj hnyuv. Qhov siab tshaj plaws ntawm cov tshuaj hauv lub cev tau mus txog tom qab 1-1.5 teev tom qab kev tswj hwm. Hauv qhov no, kev siv khoom noj khoom haus tsis cuam tshuam rau tus nqi ntawm kev nqus.

Biotransformed hauv lub siab. Nws pib raug tawm ntawm lub cev tom qab 3-5 teev, feem ntau yog nrog tso zis thiab qee qhov los ntawm txoj hnyuv. Hauv cov neeg muaj lub raum, lub sijhawm ib nrab ntawm kev siv tshuaj yuav siv sijhawm ntev dua.

Dab tsi pab

Nws yog tshuaj rau tsis muaj qhov tsis yooj yim thiab mob uas cuam tshuam los ntawm kev kis kab mob:

• ntsws-pulmonary system,
• Cov kabmob
• ib lub qhov muag
• lub qhov ncauj kab noj hniav
• raum thiab urogenital system,
• mob plab plab
• musculoskeletal system.

Rau cov menyuam yaus, cov tshuaj no tau raug sau tseg rau kev kho mob ntawm kev puas tsuaj cuam tshuam nrog pulmonary cystic fibrosis.

Cov Yuav Tsum Muaj

Digital tsis sau yog tias tus neeg mob muaj:

• rhiab rhiab rau cov tshuaj los ntawm pawg quinolone,
• mob plab pseudomembranous,
• ib daim ntawv twg ntawm epilepsy.

Digital tsis pom zoo rau siv thaum cev xeeb tub thiab thaum lub sijhawm lactation.

Ib qho ntxiv, raws li cov lus qhia rau kev siv, qhov cuab yeej no tsis pom zoo siv thaum cev xeeb tub thiab hauv lub sijhawm lactation.

Cov menyuam yaus thiab cov tub ntxhais hluas tau raug samfwm nws kom tiv thaiv tus kabmob tshwm sim los ntawm cystic fibrosis lossis kev hem thawj ntawm tus kabmob anthrax.

Ciphran tsis yog siv ua ke nrog tizanidine.

Nrog saib xyuas

Nrog ceev faj, cov neeg mob hnub nyoog tau sau tseg, nrog rau:

• nrog cerebral arteriosclerosis thiab nce siab intracranial,
• mob plawv
• nrog electrolytic swb,
• nrog raum thiab / lossis hepatic pathologies,
• nrog kev mob hlwb thiab mob vwm.

Digital 500 tau noj ua ntej noj mov, tsis tas yuav zom thiab haus nrog dej.

Nws muaj cov kev txwv yog tias tus neeg tau kuaj mob nrog cov kab mob ntawm cov khoom siv ligamentous provoked los ntawm kev noj fluoroquinolones.

Yuav ua li cas noj Tsifran 500

Noj ua ntej noj mov, tsis tas yuav zom thiab haus dej.

Cov neeg laus los kho kab mob uas tshwm sim:

• nyob rau hauv cov ntawv sau thiab nruab nrab - 0.25-0.5 g ib hnub ob zaug,
• nyob rau hauv daim ntawv loj lossis nyuaj - 0.75 g ob zaug ib hnub.

Lub sijhawm tiv thaiv yog txiav txim los ntawm daim ntawv thiab qhov loj ntawm cov chav kawm ntawm qhov kis ua mob. Txoj kev khomob yog kho raws tus kws kho mob tshwj tseg.

Qhov siab tshaj plaws ntau npaum li cas ntawm cov tshuaj yog 0.75 g, ib hnub - tsis ntau tshaj 1.5 g.

Hauv cov kab mob ntawm daim siab lossis lub raum, qhov siab tshaj plaws rau kev noj tshuaj txhua hnub yuav tsum tsis pub ntau tshaj 0.8 g (0.2-0.4 g txhua 12 teev).

Yog tias tus neeg mob muaj ntshav qab zib, cov tshuaj tua kab mob kho tau raws li tus kws kho mob tau sau tseg.

Nrog ntshav qab zib

Ciprofloxacin ntseeg tau hais tias txhim kho kev ua ntawm cov tshuaj hypoglycemic. Yog li no, thaum cov tshuaj sib xyaw ua ke no, piv txwv, nrog glibenclamide lossis glimepiride, hypoglycemic syndrome tuaj yeem tsim kho.

Yog tias tus neeg mob muaj ntshav qab zib, cov tshuaj tua kab mob kho tau raws li tus kws kho mob tau sau tseg.

Los ntawm cov hlab plawv system

Hnov ntawm palpitations, arrhythmia, tachycardia, hloov pauv ntshav siab.

Tsifran tuaj yeem ua rau muaj kev mob tshwm sim nyob rau hauv daim ntawv ntawm lub plawv mob plawv, arrhythmias, tachycardia, hloov ntshav siab.

Nruab nrab hauv lub paj hlwb

Qee cov neeg mob tshwm sim ua pa ntawm asthenia, pw ntxhov, ntxhov siab, hnov ​​lus tsis zoo, saj tsis ua hauj lwm, thiab lwm yam.

Qee cov neeg mob pw tsaug zog tsis xis nyob.

Angioneurotic edema, tawv nqaij ua pob khaus, khaus thiab anaphylactic kev ua haujlwm (tsis tshua muaj).

Cov lus qhia tshwj xeeb

Cov neeg mob uas muaj keeb kwm kho mob muaj cov lus qhia txog kev vwm, kev huam ywb, mob vauv vias lossis lub qhov txhab mob rau hauv lub hlwb yog qhov pheej hmoo ntawm cov lus teb tsis txaus los ntawm lub hauv nruab nrab cov hlab hlwb. Hauv qee kis, lub xeev kev mob hlwb tshwm sim, nrog kev xav tua tus kheej. Yog li, cov tshuaj no yog kho rau cov cim tseem ceeb xwb.

Thaum siv cov tshuaj no, kev tiv thaiv tshav ntuj yuav tsum zam kom dhau, vim nws ua rau kom muaj qhov pom kev tawm ntawm qhov muag yoog.

Siv rau lub sijhawm qub

Rau cov neeg mob laus uas lub cev tsis muaj peev xwm tiv thaiv kab mob, yav tas los kho nrog glucocorticosteroids, muaj kev pheej hmoo ntawm pob txha ntawm Achilles leeg. Yog li no, thaum pom cov tsos mob ntawm leeg leeg, Cyfran tswj hwm yuav tsum tau tshem tawm.

Rau cov neeg mob laus uas lub cev tsis muaj peev xwm tiv thaiv, muaj kev pheej hmoo ntawm pob txha ntawm Achilles leeg.

Noj ntau dhau

Cov tsos mob: cov tsos ntawm kiv taub hau, mob taub hau, zoo nkaus li qaug zog, xeev siab, thiab ntuav. Nyob rau kis ntawm kev siv ntau tshaj, nws yog ib qho tsim nyog yuav tsum tau ua cov txheej txheem detoxification txheej txheem:

• pais plab lavage,
• lub sij hawm ntawm emetics
• kev noj haus ntawm calcium thiab magnesium khoom,
• kev siv cov qhov loj ntawm cov kua dej.

Tsis tas li ntawd, nws yog qhov yuav tsum tau saib xyuas kev ua haujlwm ntawm lub tso zis, txij li thaum tsis siv tshuaj, cov tshuaj lom rau lub raum tau sau tseg.

Kev cuam tshuam nrog lwm yam tshuaj

Nrog kev siv tib lub sijhawm ua haujlwm ntawm cov tshuaj pliag plawv, tshuaj tiv thaiv kev mob ntshav siab thiab tshuaj tiv thaiv kev tiv thaiv, nws tau sau tseg nrog kev ceev faj.

Ua ke nrog Theophylline, nws txhim kho nws cov nyhuv thiab ua rau lub cev qeeb.

Nrog rau kev siv ua ke nrog phenytoin, kev hloov pauv ntawm nws lub xub ntiag hauv cov ntshav tau pom. Txhawm rau tshem tawm qhov tshwm sim ntawm kev mob cuam tshuam, kev tswj hwm ntawm phenytoin kev kho mob yog qhov tsim nyog thoob plaws txhua lub sijhawm ntawm kev sib koom tes kho.

NSAIDs (uas tsis yog acetylsalicylic acid) ua ke nrog kev txhaj tshuaj ntawm quinolones ntau tuaj yeem ua rau qaug dab peg.

Cyclosporin txuam nrog Cyfran pab ua kom muaj cov creatinine ntau hauv lub cev.

Probenecid qeeb kev tso tawm ntawm ciprofloxacin tso zis.

Ua ke nrog methotrexate, nws ua rau nws txoj kev thauj khoom hauv lub raj xa xov thiab nce qhov kev xav tau.

Kev siv Cyfran nyuaj nrog vitamin K antagonists txhim kho lawv cov tshuaj anticoagulant.

Ua ke nrog ropinirole lossis lidocaine, qhov kev pheej hmoo ntawm kev txhim kho kev mob tshwm sim ntxiv.

Ua ke nrog warfarin, nws ua rau muaj kev pheej hmoo los ntshav.

Cov txheej txheem analogue ntawm Cifran rau cov tshuaj nquag yog Ciprolet.

Cov qauv ntawm cov qauv ua kom tau zoo yog:

• Alcipro
• Tsiprolet,
• Ciprolone
• Tsiprobay,
• Cypropane
• Tsiprosan
• Tsiprosin
• Cyprosol,
• Ciprofloxabol,
• Ciprofloxacin,
• Ntxim Ntxub
• Tsifloksinal,
• Tsifran OD,
• Tsifran ST,
• Ecocifol thiab lwm tus.

Lub sijhawm tiv thaiv yog txiav txim los ntawm daim ntawv thiab qhov loj ntawm cov chav kawm ntawm qhov kis ua mob.

Cov lus pov thawj ntawm cov kws kho mob thiab cov neeg mob txog Tsifran 500

Berezkin A.V., kws kho mob, Mezhdurechensk

Ib qho dav dav siv tshuaj tua kab mob siv hauv kev phais mob, kho hniav, kho mob lub cev, urology thiab lwm yam tshwj xeeb. Kuv kuv tus kheej muab tshuaj rau cov tshuaj no tsis tshua muaj, tsuas yog tias muaj pov thawj lossis ua pov thawj raws li kev ua haujlwm thiab kev raug mob. Kuv xav tias nws zoo thiab yooj yim siv.

Kornienko L.F., kws kho mob pojniam, Irkutsk

Cov tshuaj yooj yim rau kev kho mob rau sab nrauv kev kho mob ntawm tus mob gynecological. Qhov dav dav ntawm kev txiav txim siab txiav txim siab ntawm txoj kev kho.

Alla, 25 xyoos, Ufa

Nws tau cog lus mob qa, thiab tus kws kho mob sau 500 mg rau Cyfran ntsiav tshuaj ib hnub ib zaug. Hauv lub tsev muag tshuaj ze tshaj plaws nyob hauv txoj kev siv tshuaj ntawm cov tshuaj tua kab mob no tsis yog. Kuv yuav cov tshuaj li 250 mg thiab coj 2 lub tshuaj tib lub sijhawm. Angina dhau hauv 3 hnub, tab sis tsis tau cuam tshuam nrog chav kawm. Coj li 10 hnub. Qhov tshwm sim txaus ntshai: qhov pib sai ntawm tachycardia nrog dysbiosis yog kev sib txuam tsis zoo. Tam sim no kuv tau ceev faj ntawm qhov kev kho no thiab kuv tsis zoo li yuav tsum tau noj txawm tias pom zoo los ntawm kws kho mob.

Kev taw qhia rau kev siv tshuaj Tsifran OD

Kev kis tsis yooj yim thiab cov mob nyuaj uas tshwm sim los ntawm pathogens nkag siab rau ciprofloxacin:

• mob ntsws ua pa: mob ntsws los ntawm Klebsiella spp., Enterobacter spp., Proteus spp., Escherichia coli, Pseudomonas aeruginosa, Haemophilus spp., Moraxella catarrhalis, Legionella thiab staphylococci,
• mob ntawm nruab nrab pob ntseg thiab paranasal sinuses,
• muaj kab mob ntawm lub plab hauv plab, kab mob kis ntawm lub plab zom mov, lub zais zis thiab lub duav, thiab ntxiv rau mob peritonitis,
• mob raum thiab mob txeeb zig
• mob pelvic (gonorrhea, adnexitis, prostatitis),
• kis ntawm daim tawv nqaij thiab cov nqaij mos,
• kis kab mob ntawm cov pob txha thiab pob qij txha.

Kev siv ntawm cov tshuaj Tsifran OD

Cov tshuaj yog coj tom qab noj mov. Cov ntsiav tshuaj tau nqos tag nrho. Tsis txhob txiav, tsoo, los yog zom cov ntsiav tshuaj. Cov koob tshuaj rau txhua tus neeg mob yog xaiv los xav txog lub cev qhov hnyav, hom kab mob, cov neeg mob ntawm cov kab mob, lub xeev ntawm tus neeg mob lub cev, nrog rau lub raum thiab lub siab ua haujlwm. Lub sijhawm kho yog nyob ntawm qhov mob hnyav thiab feem ntau yog 7-14 hnub.Txawm li cas los xij, rau kev kis mob hnyav lossis nyuaj, yuav tsum tau kho ntev dua.

Qhov sib npaug koob ntawm iv ciprofloxacin

500 mg (1 ntsiav tshuaj) Cyfran OD 1 zaug nyob rau ib hnub

200 mg txhua 12 teev twg

1000 mg (1 ntsiav tshuaj) Cyfran OD 1 zaug nyob rau ib hnub

400 mg txhua 12 teev

Hauv cov neeg mob uas lub raum tsis ua haujlwm, tshwj xeeb yog lub raum tsis ua haujlwm loj, yuav tsum tau txhaj tshuaj kho.
Cov lus hauv qab no muaj cov lus qhia muab tshuaj rau siv rau cov neeg mob uas lub raum tsis ua haujlwm.

Kev tshem tawm Creatinine, ml / min

Kev Siv Sijhawm

Ntsiav tshuaj Tsifran OD 500-1000 mg 1 zaug ib hnub

Cov tshuaj Cifran OD tsis pom zoo; cov tshuaj ciprofloxacin siv tau rau hauv cov koob tshuaj hauv qab no: 250-500 mg ntawm ciprofloxacin txhua 18 teev

Cov neeg mob rau ntawm hemo- lossis peritoneal lim ntshav

Cov Ntsiav Tshuaj Cifran OD tsis pom zoo, cov ntsiav tshuaj muaj peev xwm tuaj yeem siv rau hauv koob tshuaj hauv qab no: 250-500 mg ntawm ciprofloxacin txhua 24 teev (tom qab lim ntshav)

* Hauv cov neeg mob uas muaj creatinine tshem tawm ≤30 ml / min rau cov mob txeeb zig ua ke nyuaj thiab mob tsis txaus ntseeg pyelonephritis, qhov koob tshuaj yog 500 mg ntawm Cyfran OD ib hnub ib zaug.

Yog tias tsuas yog paub txog cov tshuaj creatinine hauv cov ntshav cov ntshav paub, cov qauv hauv qab no tuaj yeem siv los tshuaj xyuas creatinine:

rau txiv neej:


kev tshem tawm cov txiv neej (ml / min) =

Lub cev hnyav (kg) × (140 - hnub nyoog)

72 (ntshav creatinine (ntshav / dl))

Tsis tas yuav hloov kho qhov koob tshuaj ciprofloxacin rau cov neeg mob uas muaj kev ua haujlwm ruaj khov ntawm cov mob siab ua haujlwm ntev. Txawm li cas los xij, cov chaw muag tshuaj ntawm ciprofloxacin hauv cov neeg mob uas lub siab tsis ua hauj lwm zoo tseem tsis tau tshawb fawb txhua qhov.

Kev phiv tshuaj ntawm Tsifran OD

Zaus ≥1, ≤10%
Lub plab hnyuv plab hnyuv siab raum: xeev siab, raws plab.
Daim tawv nqaij: daim tawv nqaij ua pob.
Zaus ≥0.1, ≤≤1%
Lub cev raws li tag nrho: mob plab, candidiasis, asthenia.
Lub plab hnyuv plab hnyuv siab raum: nce rau cov kab mob siab hloov pauv: AlAT, AsAT, alkaline phosphatase, ntuav, dyspepsia, anorexia, flatulence, bilirubinemia.
Hematopoietic system: eosinophilia, leukopenia.
Cov kab mob zis: nce creatinine, urea nitrogen.
Musculoskeletal system: arthralgia.
CNS: kiv taub hau, mob taub hau, pw tsaug zog, ntxhov siab, tsis meej pem.
Daim tawv nqaij: khaus, tawv nqaij ua pob ntawm maculopapular xwm, urticaria.
Hnov kabmob siab: saj kev ua txhaum.
Zaus ≥0.01, ≤≤0.1%
Lub cev raws li tag nrho: mob, qhov mob nyob hauv cov nqaj, mob nraub qaum, hauv siab.
Lub plawv mob: tachycardia, migraine, syncope, vasodilation, hypotension.
Lub plab hnyuv plab hnyuv siab raum: candidiasis (qhov ncauj), daj ntseg, cholestatic jaundice, pseudomembranous colitis.
Txheej txheem ntshav thiab cov lymphatic system: anemia, leukopenia (granulocytopenia), leukocytosis, kev hloov ntawm theem ntawm prothrombin, thrombocytopenia, thrombocythemia (thrombocytosis).
Hypersensitivity: kev fab tshuaj tiv thaiv, ua npaws tshuaj, phiv tshuaj tsis zoo.
Kev ntshaib plab metabolic: edema (mob ntu, leeg ntshav, ntsej muag), hyperglycemia.
Musculoskeletal system: myalgia, o ntawm cov pob qij txha.
CNS: mob taub hau, mob taub hau, tawm hws, tawm pob txha caj qaum (mob hlwb paralgesia), ntxhov siab (ntshai, ntxhov siab), pw tsaug zog (npau suav phem), ua kom mob, hypersthesia, kev nyuaj siab, tshee tshee.
Kab mob ua pa: dyspnea, laryngeal edema.
Daim tawv nqaij: photosensitivity cov tshuaj tiv thaiv.
Hnov kabmob siab: tinnitus, lag ntseg ib ntus (tshwj xeeb tshaj yog nyob rau hauv lub suab ntawm lub suab), pom kev tsis pom kev (tsis pom kev tsis zoo), diplopia, chromatopsia, tsis hnov ​​qab (saj tsis zoo).
Genitourinary system: ARF, lub raum khiav tsis zoo, chaw mos candidiasis, hematuria, crystalluria, interstitial nephritis.
Zaus ≤0.01%
Lub plawv mob: vasculitis.
Lub plab hnyuv plab hnyuv siab raum: candidiasis, mob siab necrosis (tsis tshua muaj tshwm sim - kev loj hlob nrog kev loj hlob ntawm lub neej ua rau lub siab tsis ua haujlwm), pseudomembranous colitis nrog cov txiaj ntsig tuaj yeem ua rau tuag taus, kab mob pancreatitis, mob siab.
Txheej txheem ntshav thiab cov lymphatic system: hemolytic anemia, petechiae, agranulocytosis, pancytopenia (nrog rau kev hem thawj rau lub neej), inhibition ntawm cov pob txha pob txha muaj nuj nqi (nrog kev hem thawj rau lub neej).
Hypersensitivity: kev poob siab (anaphylactic, ua rau lub neej), tawv nqaij ua pob, ib cov tshuaj tiv thaiv zoo ib yam li kev mob ntshav dej.
Kev ntshaib plab metabolic: nce kev ua si ntawm amylase thiab / lossis ntshav lipase.
Musculoskeletal system: myasthenia gravis, tendonitis (feem ntau Achilles leeg leeg), ib feem los yog ua kom tiav ntawm txoj leeg (feem ntau Achilles leeg).
CNS: mob hnyav ntawm cov leeg loj, gait instability, mob hlwb, mob ntshav siab, mob ntshav qab zib, mob ntshav qab zib, tic.
Daim tawv nqaij: petechiae, erythema multiforme, erythema nodosum, Stevens-Johnson syndrome, epidermal necrolysis (Lyell's syndrome), ua pob khaus tawv.
Hnov kabmob siab: parosmia, poob ntawm cov ntxhiab tsw (feem ntau thim rov qab thaum cov tshuaj tua tsis raug mob).

Tshuaj Sib Cuam Cifran OD

Kev siv tib lub sijhawm tizanidine thiab ciprofloxacin yog contraindicated. Ib yam li lwm cov quinolones, kev sib xyaw ua ke ntawm ciprofloxacin nrog theophylline tuaj yeem ua rau muaj kev nce qib theophylline ntau ntxiv hauv cov ntshav cov ntshav thiab lub caij nyoog ntev ntawm nws lub neej ib nrab. Qhov no yuav ua rau muaj kev pheej hmoo ntawm theophylline-cuam tshuam rau kev tshwm sim tsis zoo. Yog tias kev siv ua ke siv cov tshuaj no tsis tuaj yeem zam dhau, qhov kev ntsuas ntshav theumylline yuav tsum tau saib xyuas thiab kev noj tshuaj kom zoo raws li kev tswj hwm.
Qee qhov quinolones, suav nrog ciprofloxacin, cuam tshuam rau cov caffeine metabolism. Qhov no tuaj yeem ua rau txo qis ntawm kev ua kom tshem tawm ntawm cov caffeine thiab ntev ntev ntawm nws ib nrab-lub neej los ntawm cov ntshav dej.
Kev siv ib txhij ntawm cov yeeb tshuaj ntawm chav kawm quinolone, suav nrog ciprofloxacin, nrog ntau cov tshuaj cationic, xws li antacids muaj cov tshuaj magnesium lossis aluminium hydroxide, ua tiav ua tsis haum, didanosine ntsiav tshuaj chewable, lossis cov khoom muaj cov calcium, hlau lossis zinc, tuaj yeem txo nws txoj kev nqus, vim yog coj cov kev nkag siab hauv cov ntshav dej thiab zis yuav tsawg dua qhov tsim nyog.
Antagonists ntawm histamine H2 receptors, pom tseeb, tsis txhob cuam tshuam loj heev txog kev nyab xeeb ntawm ciprofloxacin. Kev nqus ntawm Cyfran OD ntsiav tshuaj tuaj yeem txo qis me ntsis (20%) yog tias siv los siv nrog omeprazole.
Ib qho kev hloov pauv hauv cov ntshav phenytoin qib (nce los yog tsawg dua) tau pom hauv cov neeg mob uas coj ciprofloxacin tib lub sijhawm.
Kev sib xyaw ua ke siv ciprofloxacin nrog sulfonylurea tsis tshua coj los ua rau muaj ntshav nce siab ntau.
Txais tos ntawm qee cov quinolones, suav nrog ciprofloxacin, tau cuam tshuam nrog kev nce qib ntawm cov ntshav creatinine rau cov neeg mob noj cyclosporine tib lub sijhawm.
Muaj cov ntaub ntawv tshaj tawm tias quinolones, suav nrog ciprofloxacin, txhim kho kev ua ntawm lub qhov ncauj anticoagulant warfarin lossis nws cov lus dag. Yog tias tsim nyog, kev siv ua ke ntawm cov tshuaj no yuav tsum ua tib zoo saib xyuas lub sijhawm prothrombin thiab lwm yam kev ntsuas ntawm cov ntshav coagulation. Probenecid muaj feem cuam tshuam rau kev zais cia ntawm ciprofloxacin los ntawm lub raum hlab, vim tias cov tshuaj ntawm ciprofloxacin nyob rau hauv cov ntshav cov ntshav nce ntxiv. Cov xwm txheej no yuav tsum tau txiav txim siab yog tias tus neeg mob noj ob qho tshuaj tib lub sijhawm.
Kev thauj methotrexate los ntawm cov hlab ntsha plab hlaws tuaj yeem raug tshem tawm nrog kev siv ciprofloxacin tib lub sijhawm, uas ua rau muaj ntau ntxiv hauv plasma methotrexate ntau ntau. Qhov no yuav ua rau muaj kev phom sij txaus ntshai vim yog methotrexate. Cov neeg mob uas tau txais kev kho mob methotrexate yuav tsum tau saib xyuas zoo yog tias ciprofloxacin txoj kev kho tau muab rau lawv tib lub sijhawm.
Metoclopramide ua rau nrawm nrawm rau kev nqus ntawm qhov ncauj noj ciprofloxacin, yog li ua kom lub sijhawm nce mus txog nws qhov siab tshaj plaws hauv cov ntshav ntshav. Txawm li cas los xij, tsis muaj kev cuam tshuam dab tsi rau ntawm qhov kev nyab xeeb ntawm ciprofloxacin.

Cov pab pawg neeg tshwj xeeb

Hauv kev ua haujlwm hauv lub raum uas tsis zoo: Hauv cov neeg mob uas lub cev tsis zoo ua rau lub raum, lub neej ib nrab ntawm ciprofloxacin yuav nce me ntsis. Hauv qhov no, ib qho kev txhim kho ntawm kev haus tshuaj yog tsim nyog.

Thaum lub cev ua tsis tau haujlwm: Hauv kev tshawb fawb ua ntej hauv cov neeg mob uas muaj lub siab ua haujlwm ntawm lub siab ntawm daim siab, tsis muaj kev hloov pauv ntau hauv cov khw muag tshuaj ntawm ciprofloxacin tau sau tseg. Txawm li cas los xij, kev tshawb fawb txog kev kho mob ciprofloxacin hauv cov neeg mob uas muaj lub siab tsis ua hauj lwm zoo tsis tau ua.

Siv thaum cev xeeb tub thiab thaum pub niam mis

Cifran OD tsis pom zoo rau siv thaum cev xeeb tub.
Ciprofloxacin tawm hauv niam mis, yog li thaum lub sijhawm lactation, yog tias koj yuav tsum siv Cifran OD, tom qab ntawd, raws li qhov tseem ceeb ntawm nws siv rau leej niam, koj yuav tsum txiav txim siab tias yuav tsum tsis txhob noj tshuaj lossis pub mis niam.

Tsuas tshuaj thiab tswj hwm

Sab hauv.
Tsis txhob tawg, zom, lossis lwm yam rhuav tshem cov ntsiav tshuaj. Cov ntsiav tshuaj yuav tsum tau noj qhov ncauj tom qab noj mov tag nrho, muaj dej ntau.
Kev siv Tsifran OD yuav tsum txuas ntxiv tsawg kawg 2 hnub ntxiv tom qab ua tiav txoj kev ploj ntawm cov tsos mob ntawm tus mob.
Cov tshuaj pom zoo rau cov neeg laus:

Kev kho ntawm cov tshuaj regimen hauv lub raum tsis ua haujlwm:
Thaum tsis ua haujlwm raum, kev noj tshuaj hauv qab no rau cov neeg laus pom zoo:

Yog tias tsuas yog paub ntshav creatinine concentration paub, cov qauv hauv qab no raug pom zoo rau
cov lus txhais ntawm creatinine clearance:
Tus txiv neej:

Kev tshem tawm Creatinine (ml / min.) = Lub cev qhov hnyav (kg) x (140 - hnub nyoog) / 72 x ntshiab creatinine concentration (mg%)
Cov poj niam:
Kev tshem tawm Creatinine (ml / min.) = 0.85 x ntsuas ntsuas rau txiv neej.

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, raws plab, mob plab, mob plab, tsis nco qab, txhawm chim siab (tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob siab dhau los), kab mob siab, mob siab hepatonecrosis.

Los ntawm lub paj hlwb: kiv taub hau, photophobia, insomnia, paresthesia, chim siab, mob taub hau, ntau zog, ntxhov siab, tshee hnyo, "npau suav phem" npau suav, peripheral paralgesia (anomaly nyob rau hauv kev nkag siab ntawm mob), ntau ntxiv intracranial siab, tsis meej pem, kev nyuaj siab, daig, nrog rau lwm yam kev qhia kev xav hauv lub hlwb (qee lub sijhawm hloov mus rau cov xwm txheej uas tus neeg mob yuav ua rau nws tus kheej), mob taub hau, tsaus muag, mob hlwb txha nqaj qaum.

Ntawm qhov txhia chaw: kev puas ntsoog hauv kev saj thiab hnov ​​ntxhiab tsw, pom kev tsis meej (daim ntawv pov thawj, tshem tawm), tinnitus, hnov ​​lus tsis zoo.

Los ntawm cov kab mob plawv: tachycardia, mob plawv dhia tsis xwm yeem, txo cov ntshav siab, yaug ntshav ntawm daim tawv nqaij ntawm lub ntsej muag.

Los ntawm cov kab mob hematopoietic: eozoftft, leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.

Kev ntsuas ntsuas: hypoprothrombinemia, nce kev ua si ntawm hepatic transaminases, hypercreatininemia, hyperbilirubinemia, hyperglycemia, kev ua si ntau ntawm alkaline phosphatase thiab lactate dehydrogenase.

Los ntawm cov kab mob urinary: hematuria, crystalluria (feem ntau nrog cov tshuaj tiv thaiv alkaline ntawm cov zis thiab qis diuresis), mob ntsig txog mob ntshav tsis txaus (nrog rau kev txhim kho ntawm kev mob raum tsis ua haujlwm), glomerulonephritis, dysuria, polyuria, tso zis cia, albuminuria, tso zis ntawm lub cev, txo cov qe ntshav tsis ua haujlwm ntawm lub raum.

Kev tsis haum tshuaj: tawv nqaij ua pob khaus, ua xua, tsim cov hlwv nrog los ntshav, thiab cov tsos ntawm cov nodules me ua cov kiav txhab, tshuaj kub taub hau, pom cov ntshav tawm ntawm daim tawv nqaij (petechiae), o ntawm lub ntsej muag lossis larynx, dyspnea, vasculitis, erythema nodosum, erythema multiforme exudative (malignant erythema, malignant erythema, malignant erythema) Stevens-Johnson syndrome), muaj tshuaj lom epidermal necrolysis (Lyell's syndrome).

Los ntawm cov leeg musculoskeletal: mob caj dab, mob caj dab, caj dab, tendovaginitis, mob caj dab txhaws, myalgia.

Lwm yam: nce tawm hws, kev tawm suab, dav dav tsis muaj zog, superinfection (candidiasis, pseudomembranous colitis).