Kev siv tshuaj tiv thaiv zoo ntawm Traicor hauv kev tua cov rog siab

Tricor yog ib qho ntawm cov tshuaj lipid-txo qis. uas tseem hu ua fibrates.

Qhov no lub npe vim yog lub ntsiab nquag tivthaiv - fenofibrate. Nws yog ib qho muab tso ntawm fibroic acid.

Raws li nws cov cawv, cov synthesis ntawm apoprotein CIII raug txo qis, thiab tseem muaj kev txhawb nqa lipoprotein lipase pib, uas txhim kho lipolysis thiab txhawb kev nthuav dav sai ntawm atherogenic lipoproteins los ntawm cov ntshav uas muaj triglycerides.

Kev nqis tes ua ntawm fibroic acid thiab nws cov khoom siv tuaj yeem ua rau PPARa thiab ua kom nrawm rau kev sib txuas ntawm AI thiab AII apoptoreins.

Fenofibrates kuj kho cov catabolism thiab VLDL ntau lawm. Qhov no ua rau kev ntshiab ntawm LDL thiab ib qho kev txo qis hauv kev saib xyuas ntawm nws ntom thiab cov khoom me me.

Koj tuaj yeem nyeem cov kev tshuaj xyuas txog kev siv cov tshuaj no tom kawg ntawm kab lus hauv ntu tshwj xeeb.

Kev ntsuas rau siv

Tricor yog kho nyob rau hauv kev kho mob cais tawm thiab sib xyaw ntawm hypercholesterolemia thiab hypertriglyceridemia nyob rau hauv rooj plaub uas siv los ntawm kev noj zaub mov noj los yog lwm txoj kev kho tsis ua rau muaj txiaj ntsig zoo. Qhov tshwj xeeb tshaj yog siv cov tshuaj no nyob rau ntawm qhov muaj kev pheej hmoo ntxiv, xws li dyslipidemia thaum haus luam yeeb lossis mob ntshav siab.

Tricor tseem tseem raug kho rau kev kho mob ntawm hom kab mob hyperlipoproteinemia. Nyob rau hauv rooj plaub thaum hyperlipoproteinemia mob tsawv txawm tawm tsam keeb kwm ntawm kev kho tau zoo.

• nce clearance
• nce qhov concentration ntawm cov roj "zoo",
• txo qis cov roj (cholesterol) seem,
• txo qis qhov concentration ntawm fibrogen,
• txo cov qib ntawm uric acid thiab C-reactive protein hauv cov ntshav.

Tsis muaj qhov tshwm sim zoo thaum siv cov tshuaj.

Txoj kev ntawm daim ntawv thov

Cov ntsiav tshuaj yog noj ntawm qhov ncauj raws li txhua yam. Lawv yuav tsum tau nqos dej nrog dej ntau.

Nws yog ib qho tsim nyog yuav tau noj cov tshuaj thaum twg los tau, tsis hais noj zaub mov noj rau cov tshuaj nrog cov tshuaj tsis haum ntawm cov khoom nquag ntawm 145 mg. Thaum siv tshuaj nrog qhov ntau dua, yog li, 160 mg, ntsiav tshuaj yuav tsum noj ib txhij nrog zaub mov.

Rau cov neeg laus, ib koob tshuaj 1 ntsiav tshuaj yog tshuaj ib hnub ib zaug. Cov neeg noj Lipantil 200M lossis Tricor 160 tuaj yeem pib siv Tricor 145 txhua lub sijhawm yam tsis tas hloov cov koob tshuaj. Tsis tas hloov cov ntau npaum li cas, tus neeg mob tuaj yeem hloov los ntawm kev noj Lipantil 200M rau Tricor 160.

Cov neeg laus yog cia cov noj ntau npaum li qub.

Hauv raum lossis mob siab tsis txaus, qhov ntau npaum qhov tau sib tham ua ntej nrog koj tus kws kho mob.

Tricor yog kho rau kev siv mus sij hawm ntev, yuav tsum noj zaub mov kom nruj. uas tau sau tseg ua ntej teem sijhawm rau qhov cuab yeej no. Kev ua tau zoo ntawm nws txoj kev siv tau tuaj yeem ntsuas los ntawm kws kho mob kom kawm txog qhov concentration ntawm lipids hauv cov ntshav cov ntshav. Yog tias cov nyhuv xav tau tsis tshwm sim li ntawm ob peb hlis, tom qab ntawd hloov cov tshuaj kho.

Kev noj tshuaj ntau dhau tsis pom tshwm sim, tab sis yog tias muaj cim tshwm sim, kev kho mob tshwm sim yog qhov tsim nyog.

Siv cov ntsiav tshuaj tsuas yog tom qab sab laj nrog koj tus kws kho mob. Koj yuav tsum tsis txhob thov cov tshuaj ntawm koj tus kheej. Tricor tuaj yeem xaj tau hauv lub hwj tshuaj nkaus xwb.

Tso tawm daim ntawv, muaj pes tsawg leeg

Tricor muaj nyob rau hauv daim ntawv ntawm oblong ntsiav tshuaj, uas yog coated nrog nyias zaj duab xis plhaub ntawm lub teeb dawb xim. Cov ntsiav tshuaj lawv tus kheej tau sau npe nrog cov ntawv sau. Tus lej 145 yog qhia nyob rau ib sab, FOURNIER logo muab tso rau ntawm ob sab.

145 mg tshuaj muaj muag. Cov pob tuaj yeem muaj li ntawm 10 txog 300 daim. Kuj tseem ua ib daim ntawv tso tawm nrog qhov tshuaj ntawm 160 mg ntawm cov tshuaj nquag. Ib pob tuaj yeem muaj li ntawm 10 txog 100 daim. Hauv ib lub thawv ntawv cardboard uas cov tshuaj tsim tawm, muaj 3 lub hlwv nrog ntsiav tshuaj thiab lus qhia.

Hauv tshuaj muaj pes tsawg leeg, cov tshuaj yeeb yam tseem ceeb yog micronized fenofibrate.

Cov khoom siv ntxiv yog:

• lactose monohydrate,
• sodium lauryl sulfate,
• sucrose
• hypromellose,
• docusate sodium
• silica
• crospovidone
• magnesium stearate,
• lauryl sulfate.

Lub plhaub suav nrog Opadry OY-B-28920.

Kev cuam tshuam nrog lwm yam tshuaj

Thaum teem sijhawm Traicor thawj zaug, txo qhov ntau npaum ntawm coagulants siv thiab maj mam nce nws mus rau qhov tsim nyog. Qhov no yog qhov tsim nyog rau txoj kev xaiv koob tshuaj.

Kev siv cov Tricor nrog cyclosporine yuav tsum raug tswj hwm nruj. Kev tswj hwm meej meej ntawm kev sib xyaw ntawm cov tshuaj no tsis tau kawm, tab sis ntau qhov xwm txheej loj tau tshwm sim nrog kev txo qis hauv lub siab ua haujlwm. Yuav kom zam kev tshwm sim no, koj yuav tsum tau saib xyuas tas li kev ua haujlwm ntawm daim siab ua haujlwm, thiab nrog rau qhov kev hloov me me hauv cov ntsuas ntawm qhov kev ntsuas rau kev ntsuas tsis zoo, nws yog qhov yuav tsum tau ceev nrooj kom tsis tuaj tos txais tos txais Tricor.

Thaum siv cov tshuaj no nrog HMG-CoA reductase inhibitors thiab lwm cov tshuaj fibrates, tej zaum yuav muaj kev pheej hmoo ntawm cov leeg fiber ntau intoxication.

Thaum siv Tricor nrog cov enzymes ntawm cytochrome P450. txoj kev tshawb no ntawm microsomes qhia tias fenofibroic acid thiab nws cov derivatives tsis yog inhibitors cytochrome P450 isoenzymes.

Thaum siv cov tshuaj nrog glitazones, qhov thim rov qab paradoxical txo qis nyob rau hauv cov concentration ntawm HDL cov roj cholesterol hauv cov ntshav tau pom. Yog li, thaum noj cov tshuaj no, koj yuav tsum tswj hwm qhov theem ntawm HDL cov cholesterol. Yog tias nws ntog qis dua qub, koj yuav tsum tsis txhob noj Tricor.

Sab sij huam

Tricorrh muaj qee qhov kev mob tshwm sim, thaum kuaj pom tias nws yog qhov tsim nyog kom thim kev siv cov tshuaj no thiab sab laj nrog kws kho mob.

Cov tshuaj phiv:

• dyspeptic tshwm sim
• siab kev ua si ntawm daim siab enzymes,
• mob plab
• cramping thiab cov leeg tsis muaj zog,
• xeev siab
• ntuav
• diffuse myalgia,
• mob taub hau
• flatulence
• zawv plab
• nce rau hauv cov ntshav concentration ntawm leukocytes thiab hemoglobin,
• ua pob
• khaus
• kev plees kev yi
• urticaria
• alopecia
• cov hlab ntsha sib sib zog nqus thrombosis.

Cov mob tshwm sim tsis tshua muaj:

• mob hlwb
• kev ua haujlwm CPK ntau ntxiv,
• kev ua xua ntawm daim tawv nqaij
• kab mob siab
• pancreatitis
• nce ntshiab transaminase concentration,
• mob ntsws interstitial,
• cov tsos ntawm gallstones,
• kev saib duab
• mob mob vwm
• nce rau hauv cov ntshav concentration ntawm urea thiab creatinine,
• rhabdomyolysis,
• pulmonary embolism
• photosensitization.

Kho thaj chaw

Cov tshuaj nquag ntawm Tricor yog fenofibrate, uas nyob nrog pawg ntawm lipid-txo tshuaj - fibrates.

Qhov nquag metabolite ntawm fenofibrate cuam tshuam nrog cov tshwj xeeb receptors. Nws activates:

• rog lawm
• excretion ntawm triglycerides los ntawm ntshav ntshav,
• nce kev sib txuas ntawm apolipoproteins koom nrog lipid metabolism.

Raws li cov ntsiab lus, qhov siab ntawm cov roj lipoproteins tsawg (LDL) thiab cov lipoproteins tsawg tsawg (VLDL) hauv cov ntshav txo qis. Txhawb siab ntau ntawm LDL thiab VLDL nce kev pheej hmoo ntawm cov rog tso nyiaj rau ntawm cov phab ntsa ntawm cov hlab ntshav (atherosclerosis). Tib lub sijhawm, cov ntsiab lus ntawm cov lipoproteins ntau (HDL) nce, uas thauj cov roj (cholesterol) uas tsis siv los ntawm cov nqaij ua rau lub siab, uas tiv thaiv qhov tshwm sim ntawm atherosclerosis.

Tsis tas li ntawd, thaum noj fenofibrate, cov txheej txheem ntawm LDL catabolism raug kho tas lawm, uas ua rau muaj kev nce ntxiv hauv lawv txoj kev ua kom pom tseeb thiab txo qis cov ntsiab lus ntawm cov kab mob me me uas txaus ntshai tshaj plaws rau cov hlab ntshav.

Kev siv cov fenofibrate txo cov roj (cholesterol) tag nrho los ntawm 20-25%, triglycerides los ntawm 40-55% thiab nce qib ntawm cov roj "HDL" zoo los ntawm 10-30%.

Cov cim qhia rau chav kho mob yog: hom IIa, IIb, III, IV thiab V hom hyperlipidemia raws li Fredrickson. Tsis tas li ntawd, Tricor los ntawm cov roj (cholesterol) yog raug rau cov neeg mob plawv lossis cov neeg uas muaj kev pheej hmoo siab ntawm nws qhov tshwm sim. Nws yog siv hauv kev kho ua ke nrog statins hauv cov neeg mob vascular atherosclerosis lossis hom ntshav qab zib hom 2.

Tricor cuam tshuam cov plasma cov ntsiab lus ntawm cov lipoproteins uas tsis cuam tshuam dab tsi rau statins. Noj cov tshuaj no tuaj yeem txo cov kev mob ntshav qab zib, nrog rau kev muaj mob ntshav qab zib retinopathy thiab nephropathy.

Feem ntau cov kev mob tshwm sim thaum siv cov tshuaj no yog:

• lub plab zom zaws
• kev ua si ntawm ntshiab transaminases,
• mob leeg (mob leeg tsis muaj zog, leeg nqaij, leeg leeg ntshav),
• thromboembolism
• mob taub hau
• kev tsim tawm ntawm daim tawv nqaij.

Kev ceev faj yuav tsum muaj txhawm rau txo kev phiv. Hauv thawj xyoo ntawm kev kho mob, kab mob siab transaminase yuav tsum saib xyuas txhua 3 lub hlis. Hauv thawj 3 lub hlis ntawm kev kho mob, nws raug nquahu kom txiav txim siab qhov tsim nyog ntawm creatinine. Thaum myalgia thiab lwm yam kab mob tshwm sim, chav kawm ntawm kev kho mob raug tso tseg.

Kev kho mob yog nqa tawm mus ntev ntev ua ke nrog kev noj haus tshwj xeeb thiab nyob rau hauv kev saib xyuas ntawm tus kws kho mob.

Qhov ua tau zoo ntawm kev kho yog ntsuas los ntawm cov ntsiab lus ntawm lipids (tag nrho cov roj cholesterol, LDL, triglycerides) hauv cov ntshav. Thaum tsis muaj cov txiaj ntsig tom qab 3-6 lub hlis ntawm kev kho mob, nws raug nquahu kom pib kho lwm txoj kev kho.

Fenofibrate muaj ntau xyoo ntawm kev thov, nws tau tsim los ntawm Fab Kis Fournier Laboratory kho cov roj (cholesterol) ntau dua 40 xyoo dhau los.

Daim foos tso tawm ntawm Tricor yog cov ntsiav tshuaj muaj 145 lossis 160 mg ntawm cov tshuaj nquag. Cov pob muaj los ntawm 10 txog 300 ntsiav tshuaj.

Cov tshuaj zoo sib xws

Cholesterol treicor yog tsim nyob rau ntawm Fournier Laboratory ntawm SCA (Fab Kis).

Txhawm rau Tricor hloov chaw yog cov tshuaj muaj cov tshuaj qub (fenofibrate). Daim ntawv ntawm lwm cov tshuaj yog vim theej.

Muaj cov tshuaj kim dua los ntawm tib lub chaw tsim tshuaj paus - Lipantil 200 M, uas muaj cov tshuaj nquag ntau dua - 200 mg piv rau 145 mg hauv Tricor. Lipantil muaj nyob rau hauv enteric-coated tsiav tshuaj.

Ib cov tshuaj pheej yig dua ntawm Lavxias teb sab keeb kwm yog Fenofibrat Canon. Cov chaw tsim tshuaj ntawm cov tshuaj no, lub tuam txhab Canonfarm, muab cov qhua tuaj noj mov ntau xaiv nrog ntau cov ntsiav tshuaj sib txawv: 10, 20, 28, 30, 50, 60, 84, 90, 98, 100 pcs.

Tricor ntsiav tshuaj tuaj yeem sib pauv tau rau ob qho kev hloov pauv uas muaj nyob hauv tsiav tshuaj. Cov no yog Grofibrate, uas yog tsim los ntawm Grodziskie Zaklady Farmaceutyczne Polfa (Poland), thiab Exlip los ntawm Nobel Ilac Sanayii Ve Ticaret A.S. (Qaib ntxhw). Grofibrat muaj 100 mg ntawm fenofibrate, Exlip - 250 mg. Txawm li cas los xij, cov tshuaj no tam sim no tsis muaj muag.

Hauv lwm lub teb chaws, ntau qhov ntawm cov tshuaj zoo sib xws tau muag nyob rau hauv cov npe lag luam, uas txawv ntawm cov lag luam muaj npe ntawm cov tshuaj uas tsim tawm (cov lag luam). Cov no suav nrog: Antara, Fenocor-67, Fenogal, Fibractiv 105/35, thiab lwm yam.

Hauv Lavxias, Trikor rau cov roj (cholesterol) yog muag. Txawm hais tias tus nqi nyob ntawm tus nqi, nws yog nyob rau hauv kev xav tau.

Ntxiv rau cov tso tawm ntawm cov generics, koj tuaj yeem yuav cov tshuaj uas muaj cov txiaj ntsig zoo ib yam, tab sis muaj cov sib txawv uas muaj txiaj ntsig thiab koom nrog pab pawg txawv pharmacological. Ntawm lawv: Atoris, Atorvastatin, Tevastor, Tribestan, thiab lwm yam.

Koj tuaj yeem hloov Tricor nrog analogues tsuas yog tom qab kev pom zoo nrog koj tus kws kho mob.

Kev txheeb xyuas txog Tricorr thiab nws cov analogues

Feem ntau cov neeg mob ntsuas Tricor yog ib txoj hauv kev zoo los txo cov ntshav lipids. Txawm li cas los xij, ntau lub cim hais tias thaum lub sijhawm kawm txog kev kho mob, cov kev mob tshwm sim tau sau tseg: teeb meem plab zom mov, xeev siab, pom pob, thiab lwm yam

Cov kws kho mob sib txawv ntawm cov tshuaj no. Qee tus ua tiav siv Tricor los ntawm cov roj cholesterol thiab txaus siab rau cov txiaj ntsig tau los ntawm kev kho. Ntau tus endocrinologist nquag muab tshuaj Tricor, vim tias lawv suav tias nws yog tib txoj kev los tiv thaiv cov neeg mob los ntawm kev mob ntshav qab zib.

Lwm tus kws tshaj lij nyiam hloov chaw, vim tias lawv ntseeg hais tias muaj kev phiv tuaj yeem pab txhawb qhov txiaj ntsig zoo ntawm kev txo cov lipids.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Tricor yog muag hauv cov ntawv ua cov yeeb yaj kiab-tiav cov kua hauv ib pob ntawm 30 ntsiav tshuaj. Txhua ntsiav tshuaj suav nrog micronized fenofibrate 145 mg, thiab cov tshuaj hauv qab no:

• lactose monohydrate,
• sodium lauryl sulfate,
• sucrose
• hypromellose,
• silicon dioxide
• crospovidone
• sodium docusate.

Kho nyhuv

Fenofibrate yog ib qho kev tso dag los ntawm fibric acid. Nws muaj peev xwm los hloov qib ntawm ntau feem ntawm cov lipids hauv cov ntshav. Cov tshuaj muaj cov qhia hauv qab no:

1. Nce clearance
2. Txo cov lej ntawm atherogenic lipoproteins (LDL thiab VLDL) hauv cov neeg mob uas muaj feem yuav ua mob plawv,
3. Tsa nce qib ntawm cov roj "zoo" (HDL),
4. Tseem ceeb txo cov ntsiab lus ntawm cov teeb meem kev rho tawm ntawm cov roj cholesterol,
5. Qiv tshuaj fibrinogen siab,
6. Txo cov qib uric acid hauv cov ntshav thiab C-reactive protein.

Qhov siab tshaj plaws ntawm fenofibrate hauv tib neeg cov ntshav tshwm li ob peb teev tom qab siv ib zaug. Nyob rau hauv qhov xwm txheej ntawm kev siv lub sijhawm ntev, tsis muaj qhov cuam tshuam ntxiv.

Kev siv ntawm cov tshuaj Tricor thaum cev xeeb tub

Cov ntaub ntawv xov xwm me me tau qhia txog kev siv fenofibrate thaum cev xeeb tub. Hauv kev sim tsiaj, teratogenic effect ntawm fenofibrate tsis tau qhia tawm.

Embryotoxicity tshwm sim nyob rau hauv lub moj khaum ntawm kev kuaj mob hauv rooj plaub thaum txhaj tshuaj lom rau lub cev ntawm tus poj niam cev xeeb tub. Tam sim no, tsis muaj kev pheej hmoo rau tib neeg tau txheeb xyuas. Txawm li cas los xij, cov tshuaj thaum cev xeeb tub tuaj yeem siv tsuas yog los ntawm kev soj ntsuam kom zoo ntawm qhov sib piv ntawm cov txiaj ntsig thiab kev pheej hmoo.

Txij li thaum tsis muaj cov ntaub ntawv muaj tseeb ntawm kev nyab xeeb ntawm cov tshuaj Tricor thaum pub niam mis, tom qab ntawd lub sijhawm no nws tsis yog kws kho.

Cov nram qab no contraindications kom noj cov tshuaj Tricor yog:

• Ib theem siab ntawm qhov rhiab heev hauv fenofibrate lossis lwm yam tshuaj,
• Mob raum tsis ua haujlwm, xws li mob ua mob rau daim siab,
• Tsis txog 18 xyoo
• Keeb kwm ntawm kev ua kom lub ntsej muag me lossis cov duab thaij duab kho mob ketoprofen lossis ketoprofen,
• Ntau yam kab mob ntawm lub zais zis,
• Kev pub niam mis
• Cov kab mob endogenous galactosemia, tsis txaus lactase, malabsorption ntawm galactose thiab qabzib (cov tshuaj muaj lactose),
• Endogenous fructosemia, sucrose-isomaltase deficiency (cov tshuaj muaj sucrose) - Tricor 145,
• Kev fab tshuaj tiv thaiv rau cov txiv laum huab xeeb, txiv laum huab xeeb, taum pauv, lossis keeb kwm muaj khoom noj zoo sib xws (vim tias nws muaj qhov phom sij rau qhov tsis haum).

Nws yog ib qho tsim nyog yuav tsum siv cov khoom nrog ceev faj, yog tias muaj:

1. Mob raum thiab / lossis daim siab ua haujlwm,
2. Cawv kev quav cawv
3. Ntshav Qab Zib
4. Tus neeg mob laus dhau rau,
5. Tus neeg mob muaj keeb kwm muaj keeb kwm vim muaj kab mob hauv cov leeg mob.

Kev noj tshuaj ntawm cov tshuaj thiab txoj kev siv

Cov khoom yuav tsum noj ntawm qhov ncauj, nqos tag nrho thiab haus dej kom ntau. Cov ntsiav tshuaj tau siv rau txhua lub sijhawm ntawm hnub, nws tsis yog nyob ntawm seb muaj zaub mov noj ntau npaum li cas (rau Tricor 145), thiab tib lub sijhawm nrog zaub mov (rau Tricor 160).

Cov neeg laus noj 1 ntsiav tshuaj ib hnub ib zaug. Cov neeg mob uas noj 1 lub tshuaj Lipantil 200 M lossis 1 ntsiav tshuaj ntawm Tricor 160 ib hnub yuav pib noj 1 ntsiav tshuaj ntawm Tricor 145 yam tsis muaj kev hloov pauv ntxiv.

Cov neeg mob uas noj 1 lub tshuaj Lipantil 200 M ib hnub twg muaj txoj hauv kev hloov mus rau 1 ntsiav tshuaj ntawm Tricor 160 yam tsis muaj kev hloov pauv ntxiv.

Cov neeg laus yuav tsum siv cov tshuaj rau cov neeg laus: 1 ntsiav tshuaj ntawm Tricor ib hnub ib zaug.

Cov neeg mob uas lub raum tsis ua haujlwm yuav tsum txo qhov ntau npaum li cas los ntawm kev sab laj nrog kws kho mob.

Thov nco tseg: kev siv cov tshuaj Tricor hauv cov neeg mob siab tsis tau kawm. Kev txheeb xyuas tsis muab cov duab ntshiab.

Cov tshuaj yuav tsum tau noj rau ntev, thaum soj ntsuam qhov yuav tsum tau noj haus uas ib tus neeg ua raws li ua ntej pib siv cov tshuaj. Qhov ua tau zoo ntawm cov tshuaj yuav tsum tau soj ntsuam los ntawm koj tus kws kho mob.

Txoj kev kho yog ntsuas los ntawm cov qib lipid. Peb tab tom tham txog roj LDL, cov roj (cholesterol) tag nrho thiab triglycerides. Yog hais tias qhov kev ua kom zoo li tsis pom tshwm sim hauv ob peb hlis, tom qab kev teem caij ntawm lwm txoj kev kho mob yuav tsum tau tham.

Cov tshuaj cuam tshuam li cas nrog lwm cov tshuaj

1. Nrog cov tshuaj tiv thaiv kab mob hauv qhov ncauj: fenofibrate ua rau muaj txiaj ntsig ntawm kev tiv thaiv qhov ncauj thiab ua rau muaj kev pheej hmoo los ntshav. Qhov no yog vim qhov hloov chaw ntawm anticoagulant los ntawm cov ntshav protein khi cov chaw.

Nyob rau thawj theem ntawm kev kho fenofibrate, nws yog ib qho tsim nyog los txo cov koob tshuaj anticoagulants los ntawm ib feem peb, thiab maj mam xaiv cov koob tshuaj. Qhov tsuas tshuaj yuav tsum tau xaiv hauv qab tswj hwm ntawm INR qib.

1. Nrog cyclosporine: muaj cov lus piav qhia ntawm ob peb yam mob hnyav uas ua rau daim siab ua haujlwm thaum kho nrog cyclosporine thiab fenofibrate. Nws yog ib qho tsim nyog los soj ntsuam daim siab ua haujlwm hauv cov neeg mob thiab tshem tawm fenofibrate yog tias muaj kev hloov pauv hauv cov ntsuas ntshav kuaj tsis zoo.
2. Nrog HMG-CoA reductase inhibitors thiab lwm cov khoom siv fibrates: thaum noj fenofibrate nrog HMG-CoA reductase inhibitors lossis lwm cov fibrates, txoj kev pheej hmoo ntawm intoxication ntawm cov leeg pob txha ntau ntxiv.
3. Nrog rau cytochrome P450 cov enzymes: kev tshawb fawb ntawm tib neeg lub siab microsomes qhia tias fenofibroic acid thiab fenofibrate tsis ua raws li inhibitors ntawm cytochrome P450 isoenzymes:

• CYP2D6,
• CYP3A4,
• CYP2E1 lossis CYP1A2.

Ntawm kev siv tshuaj kho mob, cov tebchaw no yog cov tsis muaj zog ntawm cov CYP2C19 thiab CYP2A6 isoenzymes, nrog rau cov muaj peev xwm me lossis hnyav CYP2C9.

Ob peb cov lus qhia tshwj xeeb thaum noj cov tshuaj

Ua ntej koj pib siv cov tshuaj, koj yuav tsum tau ua kev kho mob los txiav tawm qhov ua rau ntawm hypercholesterolemia theem nrab, peb tab tom tham txog:

• tswj tsis tau tus mob ntshav qab zib hom 2,
• hypothyroidism
• cov tsos mob nephrotic
• dysproteinemia,
• obstructive daim siab mob
• kev rau txim los ntawm kev kho tshuaj,
• quav cawv.

Qhov ua tau zoo ntawm kev kho yog ntsuas raws cov ntsiab lus ntawm lipids:

• tag nrho cov roj (cholesterol)
• LDL
• ntshav dej triglycerides.

Yog tias qhov kev kho kom zoo dua qub tsis pom ntev dua peb lub hlis, tom qab ntawd lwm txoj kev kho lossis kho ntxiv yuav tsum tau pib.

Cov neeg mob hyperlipidemia uas noj tshuaj tiv thaiv hormonal tshuaj lossis estrogens yuav tsum nrhiav qhov xwm txheej ntawm hyperlipidemia, nws tuaj yeem yog thawj lossis theem nrab. Hauv cov xwm txheej no, qhov nce ntawm cov lipids tuaj yeem tshwm sim los ntawm kev noj tshuaj ntawm estrogen, uas tau lees paub los ntawm tus neeg mob tshuaj xyuas.

Thaum siv Tricor lossis lwm yam tshuaj uas txo cov tshuaj lipids, qee tus neeg mob yuav muaj kev nce siab ntawm cov neeg mob hepatic hloov dua siab tshiab.

Hauv ntau qhov xwm txheej, qhov nce yog me thiab ib ntus, hla dhau yam tsis muaj cov tsos mob pom. Hauv thawj 12 lub hlis ntawm kev kho, nws yog ib qho tsim nyog yuav tau ua tib zoo saib xyuas qib ntawm transaminases (AST, ALT), txhua peb lub hlis.

Cov neeg mob uas, thaum kho, muaj kev nce siab ntau dua ntawm kev hloov tsheb, yuav tsum tau saib xyuas tshwj xeeb yog tias qhov tshuaj ALT thiab AST yog 3 lossis ntau zaus siab dua qhov ntsuas siab dua. Hauv cov xwm txheej zoo li no, cov tshuaj yuav tsum nres sai sai.

Kev mob caj dab

Muaj cov lus piav qhia ntawm kev muaj mob ntawm kev mob ntsig txog lub sijhawm siv Traicor. Cov teeb meem ua rau ntawm pancreatitis:

• Qhov tsis muaj txiaj ntsig ntawm cov tshuaj hauv cov neeg muaj mob hypertriglyceridemia,
• Raug cov tshuaj,
• Qhov tshwm sim thib ob cuam tshuam nrog pob zeb lossis tsim kom muaj kev txo qis hauv lub zais plab, uas yog nrog los ntawm kev cuam tshuam ntawm cov bile duct.

Thaum siv Tricor thiab lwm yam tshuaj uas txo qis cov concentration ntawm lipids, cov teebmeem ntawm kev mob lom rau cov leeg nqaij tau raug tshaj tawm. Tsis tas li ntawd, tsis tshua muaj cov xwm txheej ntawm rhabdomyolysis tau sau tseg.

Cov kev tsis zoo no muaj ntau dua yog tias muaj cov mob raum tsis ua haujlwm lossis keeb kwm ntawm hypoalbuminemia.

Yuav ua rau qaug tshuaj rau cov leeg nqaij yog tias tus neeg mob yws tias:

• Mob leeg thiab cramps,
• General tsis muaj zog
• Diffuse myalgia,
• Myositis
• Ib qho kev nce siab hauv txoj kev ua ntawm creatine phosphokinase (5 zaug lossis ntau dua piv nrog qhov txwv siab ntawm qhov tsis suav).

Nws yog ib qho tseem ceeb kom paub tias hauv txhua kis no, kev kho mob nrog Tricor yuav tsum tsis ua mus ntxiv.

Hauv cov neeg mob predisposed rau myopathy, nyob rau hauv cov neeg laus dua 70 xyoo, thiab hauv cov neeg mob uas muaj keeb kwm muaj lub nra hnyav, rhabdomyolysis yuav tshwm sim. Tsis tas li, tus mob cuam tshuam:

1. Kab mob leeg mob
2. Mob raum tsis zoo,
3. Ntshav Qab Zib
4. Cawv kev quav cawv.

Cov tshuaj tau sau tseg rau cov neeg mob zoo li no tsuas yog thaum xav tias yuav muaj txiaj ntsig zoo ntawm kev kho mob ntau tshaj qhov txaus ntshai pheej hmoo ntawm rhabdomyolysis.

Thaum siv Traicor ua ke nrog HMG-CoA reductase inhibitors lossis lwm cov fibrates, qhov kev pheej hmoo ntawm kev phiv los ntawm cov leeg nqaij ua rau nce ntxiv. Qhov no muaj tseeb tshwj xeeb tshaj yog thaum tus neeg mob tau mob leeg ua ntej pib kev kho mob.

Kev sib koom tes nrog Triicor thiab statin tuaj yeem tsuas yog yog tias tus neeg mob tau mob ntshav sib xyaw ua ke thiab muaj kev pheej hmoo mob plawv heev. Yuav tsum tsis muaj keeb kwm mob cov leeg mob. Kev txheeb xyuas nruj ntawm cov cim qhia txog kev phiv tshuaj ntawm cov leeg nqaij yog qhov tsim nyog.

Renal muaj nuj nqi

Yog tias nce ntawm creatinine concentration ntawm 50% lossis ntau dua yog sau tseg, tom qab ntawd kev kho tshuaj yuav tsum nres. Hauv thawj 3 lub hlis ntawm kev kho mob nrog Triicor, creatinine concentration yuav tsum txiav txim siab.

Kev tshuaj xyuas txog cov tshuaj tsis muaj cov ntaub ntawv hais txog kev hloov pauv hauv kev noj qab haus huv thaum tsav tsheb thiab tswj cov tshuab.

Cov Yuav Tsum Tau Ua

Cov tshuaj yog contraindicated nyob rau hauv cov teeb meem nram qab no:

• daim siab pathologies
• mob raum
• mob ntsws
• qab zib intolerance,
• kab mob gallbladder
• raug rau phototoxicity lossis photosensitization,
• ua xua rau soya lecithin, txiv laum huab xeeb thiab cov zaub mov zoo sib xws.

Cov menyuam yaus thiab cov neeg laus tsis pom zoo kom siv cov tshuaj no. Tricor yuav tsum tsis txhob siv thaum tsom kwm rau ib leeg kom tsis txaus ntseeg rau cov khoom siv ntawm cov ntsiav tshuaj.

Tshwj tsis yog muaj qee qhov kev siv ntawm cov tshuaj no yog contraindicated, nws tuaj yeem siv nrog kev ceev faj thaum:

• haus cawv
• lub raum tsis ua hauj lwm
• daim siab ua hauj lwm
• hypothyroidism
• mob caj ces mob pathologies,
• tib txhij siv cov statins.

Nws tseem yuav tsum tau nco ntsoov tias ua ntej teem sijhawm Traicor, koj yuav tsum tau tshem tawm qee yam teeb meem kev noj qab haus huv:

• ntshav qab zib hom 2
• hypothyroidism
• cov leeg nephrotic,
• dysproteinemia,
• obstructive daim siab mob
• quav cawv
• kev rau txim ntawm kev siv tshuaj.

Thaum cev xeeb tub

Tricor yog nruj me ntsis contraindicated rau hauv cov poj niam cev xeeb tub thiab cov poj niam thaum lub sijhawm lactation.

Txawm li cas los xij, kev kuaj mob tshawb pom tseeb tias muaj qhov tsis zoo rau tus me nyuam hauv plab tsis tau ua. Txawm li cas los xij, embryotoxicity tau tshwm sim hauv kev teem caij siv tshuaj lom rau lub cev ntawm tus poj niam cev xeeb tub. Txawm hais tias cov tshuaj tsis yog tsim rau cov poj niam cev xeeb tub, hauv qee kis nws raug muab rau cov poj niam nyob rau lub sijhawm no thaum ntsuas qhov piv ntawm cov txiaj ntsig thiab kev pheej hmoo.

Tsis tas li ntawd, qhov tshwm sim ntawm Tricor rau cov menyuam yaus thaum lub sijhawm pub niam mis tsis pom, yog li cov kws kho mob tsis kam muab tshuaj rau lub sijhawm no.

Cov lus thiab cov xwm txheej ntawm kev cia

Tricor yuav tsum muab cia rau hauv chaw tsim khoom ntim. Tsis tas li ntawd, qhov tso cai cia kub yog 25 degrees.

Lub txee lub neej ntawm cov tshuaj yog nyob ntawm qhov kev saib xyuas ntawm cov tshuaj nquag nyob hauv cov tshuaj. Thaum nriav cov ntsiav tshuaj hauv qhov ntau npaum ntawm 145 mg, lawv lub neej txee tuaj yeem ncav cuag 3 xyoos. Thaum siv cov ntsiav tshuaj hauv qhov ntau npaum li 160 mg, lub txee lub neej txo ib xyoos thiab yog 2 xyoos.

Tus nqi ntawm cov tshuaj tsis yog nyob ntawm qhov loj me ntawm pob (qhov ntim ntawm cov ntsiav tshuaj muaj nyob hauv nws) uas nws tsim tawm, tab sis kuj tseem nyob ntawm kev saib xyuas ntawm cov tshuaj nquag.

Tus nqi nruab nrab hauv Ukraine

Koj tuaj yeem yuav Tricor hauv Ukraine ntawm tus nqi ntawm 340 txog 400 hryvnias ib pob ntawm cov tshuaj hauv qhov ntau npaum li 145 mg (20 ntsiav tshuaj).

Cov tshuaj hauv qab no zwm rau cov yeeb yaj kiab ntawm Traicor:

Kev siv cov analogues tso cai tsuas yog tom qab sab laj tus kws kho mob thiab xaiv cov tshuaj tsim nyog.

Tsis tas li ntawd, cov tshuaj no muaj txhais ua ntau. Qhov no yog Lipantil 200M. Tshaj. Fenofibrat Canon.

Kev ntsuam xyuas dav dav ntawm cov txiaj ntsig ntawm kev siv Tricor yog cov sib xyaw ntau. Qee cov kws kho mob tau sau cov tshuaj no saib qhov ua muaj txiaj ntsig zoo ntawm qhov txo qis thiab kev ua kom zoo li qub ntawm lipid profile.

Lwm tus kws kho mob thiab cov neeg mob tau yuam kom tso tseg txoj kev siv tshuaj no, vim tias nws cov kev mob tshwm sim dhau los ntawm qhov tshwm sim zoo ntawm kev siv.

Txawm li cas los xij, koj tuaj yeem thov Tricor rau kev kho mob tsuas yog tom qab sab laj nrog koj tus kws kho mob thiab kuaj xyuas qhov mob ntawm lub raum thiab mob siab. Tsuas yog hauv qhov no, yog tias tsis muaj kev pheej hmoo tshawb pom uas ua rau muaj kev cuam tshuam rau hauv tus neeg mob lub cev, nws puas tuaj yeem noj cov tshuaj no.

Kev tshuaj xyuas txog cov tshuaj tsis muaj cov ntaub ntawv hais txog kev hloov pauv ntawm lub neej zoo ntawm tus neeg thaum tsav tsheb.

• Tricor yog kho rau kev kho mob ntawm hyperlipoproteinemia, uas tsis tuaj yeem kho nrog kev noj haus.
• Siv cov tshuaj tsuas yog qhia los ntawm tus kws kho mob.
• Cov tshuaj tag nrho yog siv sab hauv, tsis hais lub sijhawm noj mov (tshwj tsis yog noj cov ntsiav tshuaj hauv 160 mg).
• Tricor yog contraindicated thaum cev xeeb tub thiab lactation, mob siab thiab lub raum tsis ua hauj lwm, ua rau lub ntsej muag tsis haum rau lub Cheebtsam ntawm cov tshuaj, thiab nws kuj tsis pom zoo rau menyuam yaus.
• Cov tshuaj muaj pes tsawg tus raug kev mob tshwm sim.
• Ceev faj yog qhia kom siv Tricor nrog qee yam tshuaj.

Zaj lus puas pab koj? Tej zaum nws yuav pab koj cov phooj ywg thiab! Thov, nyem rau ntawm ib lub nyees khawm:

Analogs Tricor

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 418 rubles. Cov analogue yog pheej yig dua los ntawm 380 rubles

Qhov sib tw raws cov cim

Nqe los ntawm 433 rubles. Cov analogue yog pheej yig dua los ntawm 365 rubles

Qhov sib tw raws cov cim

Tus nqi yog los ntawm 604 rubles. Cov analogue yog pheej yig dua los ntawm 194 rubles

Cov kws kho mob tshuaj xyuas txog lub tsheb laij teb

Nws zoo heev yog tias koj yuav tsum kho cov qib triglycerides.

Cov hauj lwm zoo tsis yooj yim pom thiab qhov ntim ntawm qee zaum cov kev mob tshwm sim tau ntau lo lus nug.

Qhov tseeb, fenofibrate yog qhov zoo tshaj plaws rau ob qho tib si kev kho plawv thiab endocrinological rau hypertriglyceridemia. Raws li koj paub, endocrinologist, tshwj xeeb tshaj yog niaj hnub no, tsuas yog ua neeg vwm nrog lub luag haujlwm ntawm triglycerides, thiab thaum txheeb xyuas hypertriglyceridemia hauv kev kho plawv, Kuv xav kom nws ua txoj hauv kev xaiv.

"Tricor" yog tus neeg sawv cev hypolipidemic, tab sis kom ntau dua qhov txo qis triglycerides. Kuv pom zoo rau hom IIa, IIb, III thiab IV hyperlipoproteinemia. Koob tshuaj thiab lub sijhawm siv kho - ib tus zuj zus. Tsis muaj cov kev mob tshwm sim.

Nws tsis muaj teebmeem tshwj xeeb rau kev txo cov roj (cholesterol). Contraindicated nyob rau hauv mob siab mob siab.

Kev Ntsuas Hluav Taws Xob

Kuv muaj kev xav tsis zoo txog kev caij tsheb. Nws coj nws mus kwv yees li 1 xyoos hloov ntawm torvacard. Qhov laj thawj tseem ceeb rau kev hloov pauv yog qhov pheej tsis tu ncua ntawm HDL thaum noj torvacard. Tom qab 4-5 lub hlis, paroxysmal ntu ntu ntawm tsam plab thiab xeev siab pib tshwm - 1-2 zaug hauv ib hlis, thiab 8-9 lub hlis tom qab nres tom qab nws tau ua haujlwm rau (3 xyoos dhau los) rau biliary colic. Hauv cov zais zis ua kom tshem tawm muaj viscous bile thiab qee lub pob zeb xoob. Muaj tsis muaj teeb meem ntawm lub plab thiab lub zais zis ua ntej noj lub treicor. Tom qab lub lag luam, kev tawm tsam nres. Qhov kev mob tshwm sim no tau piav qhia nyob hauv cov tshuaj siv qhia.

Kuv nyob hauv lub nroog Stavropol kuv tus kheej, hnub nyoog - 53 xyoos. Kuv haus "Tricor" txij li xyoo 2013. Kuv sau tus kws kho mob ntsej muag Irina Olegovna Gadzalova. Kuv cov kab mob: mob ntshav qab zib retinopathy. Lub qhov muag sab laug - peb txoj haujlwm ntawm retina, lub teeb hloov los ntawm IOL, laser coagulation rov ua dua. Lub qhov muag sab xis - ob txoj haujlwm ntawm qhov retina (ib qho hais txog kev rub tawm), IOL, laser coagulation. Ua tsaug rau "Tricor", kev rov ua haujlwm tom qab ntawm lub zeem muag yog sai dua thiab zoo dua. Tsis tas li ntawd, "Tricor" txo cov roj ntshav kom rov qab zoo li qub. Kuv haus nws tsis tu ncua (10 lub hlis - tom qab ntawd 2 lub hlis so). Kuv tsis pom tias muaj kev mob tshwm sim.

Cov Tshuaj Pharmacokinetics

Tom qab noj fenofibrate hauv C_max ua tiav nyob hauv 5 teev. Thaum noj 200 mg / hnub, qhov nruab nrab ntshav plasma concentration yog 15 μg / ml. Tus nqi C_ss tswj thoob plaws hauv lub sijhawm kho. Kev khi rau cov ntshav plasma protein (albumin) yog qhov siab. Hauv cov ntaub so ntswg, fenofibrate tau hloov pauv mus rau hauv qhov tseem ceeb ntawm cov metabolite - fenofibroic acid. Cov tshuaj txiav tawm hauv daim siab.

T_1/2 yog 20 teev .Nws raug excreted los ntawm lub raum thiab los ntawm cov hnyuv. Nws tsis nthuav dav, tsis yog tawm thaum lub sij hawm hemodialysis.