Dalacin C.

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb DalacinCov. Muab tswv yim los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv cov tshuaj tua kab mob Dalacin hauv lawv cov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Dalacin analogues nyob rau hauv muaj cov qauv txheej txheem qauv. Siv rau kev kho mob ntxau (mob ntxau), ua npaws caws pliav, tonsillitis thiab lwm yam mob hauv cov neeg laus, menyuam yaus, nrog rau lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Dalacin - tshuaj tua kab mob semisynthetic ntawm linkosamide pawg, tsim los ntawm lincomycin thaum pawg 7- (R) -hydroxyl hloov los ntawm 7- (S) -chlor, nquag tawm tsam aerobic gram-zoo cov kab mob me me thiab ntau cov kab mob anaerobic. Feem ntau cov kab mob gram-negative aerobic, suav nrog Enterobacteriaceae, tiv taus clindamycin.

Lincosamides, zoo li macrolides (piv txwv, erythromycin), khi rau 50S ntu ntawm cov kab mob ribosome thiab inhibit protein synthesis thaum ntxov. Ua raws li kev nkag siab ntawm cov kab mob microorganism thiab cov tshuaj ntawm cov tshuaj, clindamycin tuaj yeem ua bacteriostatically (feem ntau) lossis bactericidal (hauv qhov siab).

Cov kab mob hauv qab no yog rhiab rau clindamycin hauv vitro:

1. Aerobic gram-zoo cocci, suav nrog: Staphylococcus aureus, Staphylococcus epidermidis (kev tsim tawm thiab tsis tsim cov tshuaj penicillinase). Nws tau sau tseg (hauv vitro) txoj kev loj hlob sai ntawm kev tsis kam rau clindamycin hauv qee qhov staphylococcal erythromycin tiv thaiv kab mob. Streptococcus spp. (tshwj tsis yog Streptococcus faecalis), Pneumococcus spp.

2. Anaerobic gram-negative bacilli, suav nrog: Bacteroides spp. (suav nrog cov pab pawg ntawm B. fragilis, B. disiens, B. bivius thiab B. melaninogenicus), Fusobacterium spp.

3. Anaerobic gram-zoo, tsis muaj cov tshuaj pleev ib qho los ntawm bacilli, suav nrog Propionibacterium spp., Eubacterium spp., Actinomyces spp.

4. Anaerobic thiab microaerophilic gram-zoo cocci, suav nrog Peptococcus spp., Peptostreptococcus spp., Microaerophilic Streptococcus spp., Clostridia spp.: Clostridia tiv taus ntau dua clindamycin ntau dua lwm cov tshuaj anaerobes. Feem ntau Clostridium perfringens nkag siab zoo rau clindamycin, tab sis lwm hom, xws li C. sporogenes thiab C. tertium, feem ntau tiv taus clindamycin, yog li yuav tsum kuaj qhov mob rhiab.

5. Muaj ntau yam kab mob hauv lub cev, suav nrog Chlamydia trachomatis, Toxoplasma gondii, Plasmodium falciparum thiab Pneumocystis carinii (ua ke nrog primaquin), Gardnerella vaginalis, Mobiluncus mulieris, Mobiluncus curtisii, Mycoplasma hominis.

Cov kab mob me me hauv qab no feem ntau tiv thaiv clindamycin: aerobic gram-tsis zoo bacilli Streptococcus faecalis, Nocardia spp., Neisseria meningitidis, mob ntawm methicillin-resistant Staphylococcus aureus thiab hom kab mob ntawm Haemophilus influenzae. Cov kab mob sib kis muaj nyob ntawm lincomycin thiab clindamycin.

Muaj pes tsawg leeg

Clindamycin + excipients.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, kev nrawm nrawm thiab yuav luag tiav (90%) nqus ntawm dalacin tshwm sim. Thaum noj ntawm qhov ncauj, qhov nqus ntawm clindamycin (ntau npaum li cas) tsis yog nyob ntawm ntau ntau ntawm kev sib txig sib xyaw nrog cov khoom noj, tab sis kev noj nrog zaub mov tuaj yeem ua rau nqus qis. Muaj txoj kab sib txuas ntawm qhov ua kom sib haum ntawm clindamycin hauv cov ntshav dej thiab cov tshuaj ntawm cov tshuaj noj. 40-90% ntawm cov tshuaj muab khi rau cov protein nyob hauv lub cev. Clindamycin tsis nkag rau hauv lub hlwb-hlwb teeb meem (BBB) ​​(txawm hais tias muaj mob ntawm daim npluag qhwv, permeability nce me ntsis). Tsis hloov, kwv yees li 10% ntawm cov tshuaj tau tawm hauv lub cev los ntawm lub raum, 3.6% - nrog quav. Cov nyiaj uas seem yog tawm ua cov roj ntsha uas tsis ua haujlwm, feem ntau yog cov kua tsib thiab cov quav. Clindamycin tsis raug cais tawm los ntawm hemodialysis thiab peritoneal lim ntshav.

Cov Khoom Qhia

Cov kab mob sib kis thiab mob tau tshwm sim los ntawm kab mob clindamycin-sensitive anaerobic lossis hom kab mob ntawm cov kab mob aerobic gram, zoo li Streptococcus spp., Staphylococcus spp. thiab Pneumococcus spp., thiab raws li clindamycin rhiab Chlamydia trachomatis serovars:

• sab sauv ntawm txoj hlab ua pa, nrog rau tonsillitis, pharyngitis, mob ntsws,
• mob pob ntseg hauv nruab nrab, ntsej muag caws pliav,
• kis kab mob ntawm cov pa hauv theem qis, suav nrog mob ntsws, mob ntsws, empyema ntawm pleura thiab mob ntsws rwj,
• kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau pob txuv (mob ntxau), furunculosis, kis ntawm subcutaneous rog, mob pob txha, mob qog, mob viav vias, muaj kev sib kis hauv cov tawv nqaij thiab cov nqaij mos ua kom mob los ntawm pathogens rhiab rau cov tshuaj no, xws li erysipelas thiab paronychia (panaritium),
• kis kab mob ntawm cov pob txha thiab pob qij txha, suav nrog osteomyelitis thiab mob leeg caj dab,
• gynecological kis kab mob, suav nrog endometritis, mob sib kis ntawm cov rog subcutaneous, kis kab mob ntawm cov nqaij mos uas nyob ib puag ncig ntawm lub paum, qog ntawm txoj hlab qe ntshav thiab lub zes qe menyuam, salpingitis thiab mob rau ntawm cov plab hnyuv siab raum, ua ke nrog cov tshuaj tua kab mob uas ua haujlwm tawm tsam gram-negative aerobic pathogens (e.g. gentamicin),
• monotherapy ntawm ncauj tsev menyuam mob tshwm sim los ntawm Chlamydia trachomatis,
• cov kab mob sib kis ntawm lub plab, nrog rau mob peritonitis thiab mob plab (ua ke nrog lwm cov tshuaj tua kab mob uas ua rau cov kab mob gram-negative aerobic),
• septicemia thiab endocarditis,
• muaj mob ntawm qhov ncauj kab noj hniav, xws li ncig ncig ua paug thiab ntu,
• toxoplasma encephalitis hauv cov neeg mob AIDS (ua ke nrog pyrimethamine hauv cov neeg mob uas tsis nkag rau kev kho tus qauv),
• Pneumocystis mob ntsws nyob rau hauv cov neeg mob AIDS (ua ke nrog cov tshuaj primaquine hauv cov neeg mob uas tsis tuaj yeem lossis tiv taus nrog kev kho tus qauv),
• malaria, incl. tshwm sim los ntawm multiresistant Plasmodium falciparum, ob qho tib si rau kev kho mob, thiab kev sib xyaw nrog quinine lossis chloroquine,
• kev tiv thaiv ntawm endocarditis nyob rau hauv cov neeg mob uas muaj kev rhiab heev rau penicillins,
• cov kab mob vaginosis.

Tso Tawm Cov Ntawv

Cov tshuaj lub thaj 150 mg thiab 300 mg (qee zaus hu ua ntsiav tshuaj yuam kev).

Cov Lus Qhia Txog Kev Phom Sij lub chaw mos 100 mg No. 3.

Nkag rau kev siv sab nraud 1% (Dalacin T).

Vaginal lee 3% (qee zaus hu ua tshuaj tsw qab).

Kev daws rau kev tso tshuaj thiab tshuaj ntshav (Dalacin Ts phosphate) (kev txhaj tshuaj hauv ampoules rau kev txhaj tshuaj).

Cov lus qhia rau kev siv thiab ntau npaum li cas

Txhawm rau kom tsis txhob muaj teeb meem, siv nruj me ntsis raws li kws kho mob qhia.

Cov neeg laus: 600-1800 mg / hnub noj hauv 2, 3 lossis 4 koob tshuaj (sib npaug ib zaug).

Cov menyuam yaus: 8-25 mg / kg lub cev hnyav / hnub los ntawm qhov ncauj hauv 3-4 koob (txhaj koob tshuaj sib npaug).

Txhawm rau kom tsis txhob khaus ntawm txoj hlab pas, lub tsiav tshuaj yuav tsum tau noj nrog lub khob dej.

Yog tias cov koob tshuaj suav yog ib koob tshuaj qis dua cov ntsiab lus clindamycin hauv tshuaj ntsiav lossis muaj cov nqos tsis haum, daim ntawv niam txiv cov tshuaj yuav tsum pom zoo.

Cov kab mob uas tshwm sim los ntawm beta-hemolytic streptococcus: koob tshuaj tau qhia saum toj no, kev kho yuav tsum txuas ntxiv tsawg kawg 10 hnub.

Cov kab mob sib kis thiab mob ntawm lub plab hu ua: 900 mg iv clindamycin txhua 8 teev + iv tus neeg sawv cev tiv thaiv kab mob uas ua haujlwm tawm tsam gram-negative aerobic pathogens (piv txwv li, gentamicin ntawm koob ntawm 2.0 mg / kg ua raws li 1.5 mg / kg txhua txhua 8 teev rau cov neeg mob lub raum kev ua haujlwm), tsawg kawg 4 hnub, thiab tom qab tus neeg mob tus mob zoo dua, tsawg kawg 48 teev. Tom qab ntawd lawv hloov mus rau noj clindamycin sab hauv los ntawm 450-600 mg txhua 6 teev txhua hnub. Tag nrho cov chav kawm ntawm kev kho mob yog 10-14 hnub.

Chlamydia trachomatis mob ntawm lub ncauj tsev menyuam: 450-600 mg rau qhov ncauj 4 zaug nyob rau ib hnub ib hnub rau 10-14 hnub.

Toxoplasmosis encephalitis hauv cov neeg mob AIDS: hauv cov neeg mob uas tsis txaus siab rau kev kho mob, clindamycin yog siv nrog pyrimethamine raws li cov txheej txheem hauv qab no: 600-1200 mg rau qhov ncauj txhua 6 teev rau 2 lub lis piam, tom qab ntawd 300-600 mg tshuaj txhua 6 teev .Pyrimethamine raug kho ntawm koob tshuaj 25 -75 mg rau qhov ncauj txhua hnub. Feem ntau, chav kawm ntawm kev kho mob yog 8-10 lub lis piam. Thaum siv tshuaj ntau dua ntawm pyrimethamine, folinic acid yuav tsum tau kho nyob rau hauv ib koob ntawm 10-20 mg / hnub.

Pneumocystis mob ntsws rau cov neeg mob AIDS: 300-450 mg qhov ncauj txhua 6 teev rau 21 hnub thiab primaquine 15-30 mg qhov ncauj ib hnub ib zaug rau 21 hnub.

Acute streptococcal tonsillitis / pharyngitis: 300 mg qhov ncauj 2 zaug hauv ib hnub rau 10 hnub.

Malaria: 10-20 mg / kg / hnub qhov ncauj rau cov neeg laus thiab 10 mg / kg / hnub rau cov menyuam yaus txhua 12 teev hauv kev muab sib npaug rau 7 hnub raws li kev kho mob monotherapy, lossis kev sib txuas nrog quinine (12 mg / kg txhua 12 teev) lossis chloroquine (15-25 mg txhua 24 teev) rau 3-5 hnub.

Kev tiv thaiv ntawm endocarditis nyob rau hauv cov neeg mob uas muaj kev sib raug zoo rau penicillins: 600 mg qhov ncauj rau cov neeg laus thiab 20 mg / kg rau cov menyuam 1 teev ua ntej kev phais me lossis kho hniav lossis lwm yam txheej txheem cuam tshuam nrog kev pheej hmoo ntawm endocarditis.

Cov neeg laus laus: tsis tas yuav hloov kho lub koob tshuaj nrog rau ib txwm muaj (rau lub hnub nyoog muab) daim siab thiab lub raum ua haujlwm.

Sab nraud. Ib txheej txheej ntawm gel yog thov rau thaj tsam cuam tshuam ntawm huv si qhuav tawv nqaij 2 zaug hauv ib hnub. Txhawm rau kom tau txais txiaj ntsig zoo, kev kho mob yuav tsum txuas ntxiv rau 6-8 lub lis piam, thiab yog tias tsim nyog, koj tuaj yeem txuas ntxiv mus txog 6 lub hlis.

Ib koob tshuaj (1 daim ntawv thov tag nrho (5 g ntawm lee, kwv yees li 100 mg ntawm clindamycin)) raug muab rau hauv lub paum, nyiam dua thaum lub sijhawm pw, rau 3 lossis 7 hnub sib law liag.

Hauv ib pob nrog 20 g ntawm cream muaj 3 tus neeg thov siv yas, thiab hauv ib pob nrog 40 g muaj 7 tus neeg thov rau qhov qhia qhov tseeb ntawm cov cream rau hauv chaw mos.

Cov kev cai rau kev siv tshuaj

1. Tshem lub hau ntawm lub raj ntawm cov cream. Ntsia cov yas thov rau ntawm txoj hlua xov ntawm lub raj.
2. Thaum dov lub raj los ntawm qhov kawg rov qab, maj mam muab nyem cov qab zib rau hauv tus neeg thov. Tus neeg thov siv tau tag nrho thaum nws lub piston mus txog ntawm nres.
3. Tshem cov neeg thov ntawm lub raj thiab qhwv lub hau.
4. Thaum pw ntawm koj sab nraub qaum, rub koj lub hauv caug rau hauv siab.
5. Tuav tus neeg thov kev pab ua haujlwm tav toj, ua tib zoo ntxig nws mus rau hauv lub qhov paum kom tob li sai tau, yam tsis ua rau tsis zoo siab.
6. Maj mam thawb lub piston txhua txoj kev, muab cov roj tov rau hauv lub paum.
7. Ua tib zoo tshem tus neeg thov kev pab tawm hauv chaw mos thiab muab pov tseg.

Sab sij huam

• mob plab
• xeev siab, ntuav,
• zawv plab
• txoj hlab pas
• txoj hlab pas rwj
• mob plab pseudomembranous,
• dysbiosis,
• maculopapular pob,
• urticaria
• khaus
• qhua pias qhua pias ua pob liab liab rau mob sib khuav
• erythema multiforme,
• exfoliative thiab vesiculo-bullous dermatitis,
• lom epidermal necrolysis,
• anaphylactoid kev tsis haum
• cov neeg mob neutropenia (leukopenia) thiab eosinophilia ntawm lub qhov xwm txheej tau dhau los,
• vaginitis
• kev loj hlob ntawm superinfection.

Cov Yuav Tsum Tau Ua

• ua kom lub cev tsis haum rau clindamycin, lincomycin lossis ib qho tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Clindamycin hla lub tsho me me. Tom qab qhia txog ntawm ob peb koob tshuaj, cov tshuaj nyob hauv cov kua dej muaj yees li ntawm 30% ntawm cov concentration ntawm leej niam cov ntshav. Clindamycin yuav tsum siv nyob rau hauv cov poj niam cev xeeb tub tsuas yog hais tias lub hom phiaj tau txais txiaj ntsig rau leej niam tshaj qhov cuam tshuam txog kev pheej hmoo rau tus me nyuam. Clindamycin pom nyob rau hauv niam cov kua mis ntawm ib qho tshuaj 0.7-3.8 μg / ml.

Yog tias tsim nyog, kev teem sij hawm thaum lactation yuav tsum tsis pub mis niam.

Cov lus qhia tshwj xeeb

Yog hais tias mob ncauj tsev menyuam mob los ntawm Chlamydia trachomatis, clindamycin monotherapy ua tau zoo rau kev kho kom tiav.

Cov kab mob pseudomembranous colitis ntawm qhov sib txawv ntawm lub neej muaj kev phom sij tau pom nrog kev siv yuav luag txhua tus kab mob antibacterial, suav nrog Dalacin, yog li txhua tus neeg mob zawv plab tom qab siv tshuaj tua kab mob, qhov tseem ceeb ntawm kev kuaj mob no yuav tsum raug txiav txim siab. Cov tshuaj tua kab mob tua cov kab mob plab hnyuv qub, uas tuaj yeem pab txhawb kom muaj kev tawm tshiab ntawm clostridia. Nws tau raug pov thawj tias cov co toxins uas ua los ntawm Clostridium difficile yog qhov tseem ceeb ntawm kev mob plab txuam nrog tshuaj tua kab mob. Kev mob pseudomembranous muaj peev xwm tshwm sim ob qho tib si thaum noj clindamycin, thiab 2-3 lub lis piam tom qab nres kev kho mob, nws tau ua kom mob raws plab, mob leukocytosis, ua npaws, mob plab (qee zaum nrog los ntawm kev tso quav nrog quav thiab ntshav). Tom qab kuaj mob pseudomembranous colitis tau kuaj pom muaj mob me, kev kho mob thiab kev siv cov ion pauv resins (colestyramine, colestipol) muaj peev xwm tso tseg tsis txaus, nyob rau qhov muaj mob loj tsawv thiab mob hnyav, kev them nyiaj rau cov kua dej, electrolytes thiab protein ntau, kev teem sijhawm ntawm cov tshuaj tua kab mob zoo los tiv thaiv Clostridium difficile, piv txwv li, vancomycin nyob rau hauv ib koob tshuaj 125-500 mg, lossis bacitracin hauv ib koob ntawm 25 000 IU sab hauv 4 zaug hauv ib hnub rau 7-10 hnub, lossis metronidazole 250-500 mg 3 zaug hauv ib hnub. Cov tshuaj uas txo qis plab hnyuv kom tsis tuaj yeem hais kom ib txhij nrog clindamycin.

Thaum siv tag nrho cov kab mob antibacterial, suav nrog clindamycin, kev loj hlob ntau ntawm cov kab mob me tsis txaus ntseeg rau cov tshuaj no, tshwj xeeb tshaj yog cov poov xab zoo li fungi, muaj peev xwm ua tau. Nrog rau kev txhim kho superinfection, kev ntsuas tsim nyog yuav tsum tau ua raws li kev kuaj mob.

Clindamycin yuav tsum tsis txhob raug kho rau kev kho mob rau daim npluag qhwv paj hlwb, vim tias nws nkag mus rau cov ntshav tsis zoo-thaiv hlwb (BBB).

Thaum muab tshuaj rau hauv cov tshuaj siab, nws yog ib qho tsim nyog los tswj kev xav ntawm clindamycin hauv lub ntshav. Yog hais tias kev kho mob yog nqa tawm nyob rau ncua sijhawm, tom qab ntawv kuaj daim siab thiab lub raum yuav tsum ua haujlwm tsis tu ncua.

Hauv cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm, tsis tas yuav hloov kho qhov tshuaj ntawm cov tshuaj, vim tias clindamycin kev xyaum tsis nthuav tawm hauv lub cev yog tias cov tshuaj noj ntawm qhov ncauj nrog lub sijhawm ntev txog 8 teev.

Yeeb tshuaj sib cuam tshuam

Nws tau tsim tau tias hauv vitro cov kev thaiv kev sib deev ntawm dalacin thiab erythromycin yog tshwm sim. Txij li thaum qhov kev tawm tsam no tej zaum yuav tseem ceeb hauv cov kab mob, cov tshuaj no yuav tsum tsis txhob noj nyob rau tib lub sijhawm. Muaj cov pov thawj ntawm kev sib cuam tshuam zoo sib xws nrog chloramphenicol.

Nws tau raug tsim los hais tias Dalacin cuam tshuam kev sib deev neuromuscular thiab, yog li ntawd, tuaj yeem txhim kho cov nyhuv ntawm lwm cov leeg txuas ntxiv, yog li, cov tshuaj yuav tsum siv nrog ceev faj hauv cov neeg mob tau txais tshuaj ntawm pawg no.

Siv tib lub sijhawm opioid (narcotic) analgesics, uas muaj qhov cuam tshuam hauv nruab nrab ntawm kev ua haujlwm ntawm lub ntsws ua pa, tuaj yeem ua rau ntau cov lus qhia ua pa nyuaj siab mus rau apnea.

Tib lub sij hawm tswj hwm nrog cov tshuaj tiv thaiv kab mob uas txo qis plab hnyuv kom muaj feem ua mob pseudomembranous mob.

Aminoglycosides nthuav tawm lub spectrum ntawm antimicrobial kev txiav txim ntawm clindamycin.

Cov tshuaj sib piv ntawm cov tshuaj Dalacin

Cov qauv ntawm cov qauv ua haujlwm:

• Dalacin C xov,
• Zerkalin,
• Klimitsin,
• Clindamycin,
• Klindatop,
• Klindafer
• Clindacin
• Klaus,
• Klindovit.

Kev ntsuas rau siv

Cov kab mob kis tau los ntawm cov kab mob me me: kis mob rau cov kabmob ENT (nrog rau tonsillitis, pharyngitis, sinusitis, otitis media), ua mob ua pa (mob ntsws, mob ntsws, mob ntsws, ua rau pleural empyema, fibrosing alveolitis), kis mob ntawm cov pob txha thiab pob qij txha ( osteomyelitis, septic mob caj dab), purulent kis ntawm daim tawv nqaij thiab cov nqaij mos (nrog rau mob ntxau, rwj, phlegmon, mob ua paug, kab mob panaritium, mob viav vias, mob qog ntshav, erysipelas), sepsis (feem ntau anaerobic), mob pelvic thiab mob intraperitoneal ( suav nrogperitonitis, ua mob ntawm lub plab ua hauj lwm nrog rau kev siv cov tshuaj ib txwm ua tawm tsam gram-negative aerobic microbes), cov kab mob gynecological (endometritis, adnexitis, colpitis, ua mob ntawm cov hlab ntaws thiab lub zes qe menyuam, salpingitis, mob hu ua paum leeg). rwj), toxoplasma encephalitis, malaria (tshwm sim los ntawm Plasmodium falciparum), mob ntsws (mob ntsws los ntawm Pneumocystis carinii), sepsis, endocarditis, chlamydia, kub taub hau, diphtheria.

Dosage daim ntawv

Cov tshuaj ntsiav 150 mg, 300 mg

Ib qho tshuaj ntsiav muaj:

cov tshuaj heev - clindamycin hydrochloride 177.515 mg lossis 355.030 mg (sib npaug rau clindamycin 150 mg lossis 300 mg),

tus zam: magnesium stearate, pob kws hmoov txhuv nplej, talc, lactose monohydrate,

Tshuaj ntsiav plhaub muaj pes tsawg leeg: titanium dioxide (E 171), nkaws.

Cov khoom tawv opaque gelatin tsiav tshuaj nrog lub hau thiab lub cev dawb, dub number case luam tawm hom "Pfizer" thiab cov code "Clin 150". Tus txheem ntawm cov tsiav tshuaj yog hmoov dawb (rau qhov ntau npaum li 150 mg).

Cov khoom tawv opaque gelatin tsiav tshuaj nrog lub hau thiab lub cev dawb, dub number case luam tawm hom "Pfizer" thiab cov code "Clin 300". Tus txheem ntawm cov tsiav tshuaj yog hmoov dawb (rau qhov ntau npaum li 300 mg).

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, clindamycin tau nrawm thiab yuav luag nqus (90% ntawm cov koob tshuaj).

Kev noj zaub mov zoo ib txhij tsis cuam tshuam rau kev txiav txim siab ntawm cov tshuaj hauv ntshav ntshav.

Ntshav Siab Ntau

Hauv cov neeg laus noj qab haus huv, cov ntshav plasma ntau ntau yog li 2-3 mg / L thiab raug soj ntsuam ib teev tom qab kev tswj hwm ntawm 150 mg ntawm clindamycin hydrochloride lossis 4-5 mg / L tom qab kev tswj hwm ntawm 300 mg. Tom qab ntawd, cov ntshav plasma concentration dauv qeeb qis, seem saum toj 1 mg / L rau ntau tshaj 6 teev. Plasma concentration nce linearly nyob rau hauv qhov nce nyob rau hauv lub koob noj. Ntshav siab yuav tau tshaj tawm me ntsis hauv cov neeg mob ntshav qab zib dua li cov neeg mob noj qab nyob zoo. Qhov nruab nrab roj ntsha ib nrab-lub neej ntawm clindamycin los ntawm cov ntshav dej yog 2.5 teev.

Ntshav Protein losis tswvyim dabtsi

Kev khi rau cov ntshav plasma protein yog li ntawm 80 txog 94%.

Kev ncig hauv cov ntaub so ntswg thiab dej ntawm lub cev

Clindamycin yog dav faib nyob rau hauv cov kua dej ntau dhau ntawm cov kua dej ntxiv thiab tso ntshav thiab hauv cov ntaub so ntswg. Diffusion rau hauv cerebrospinal kua yog tsawg tsawg.

Clindamycin yog tshuaj tiv thaiv hauv lub siab.

Kwv yees li 10% ntawm cov tshuaj nyob rau hauv daim ntawv nquag yog tawm hauv cov zis thiab 3.6% yog tawm hauv cov quav. Cov seem yog tawm los uas tsis ua haujlwm ntawm metabolites.

Ntshav clindamycin ntau tsis hloov vim yog los ntawm hemodialysis lossis peritoneal lim ntshav.

Cov Tshuaj Hauv Tshuaj

Cov cwj pwm hauv qab no tsis pub muaj kev txwv qis tshaj plaws (MIC) yog siv los qhia qhov sib txawv ntawm cov kab mob muaj sia, cov kab mob muaj feem cuam tshuam tsawg, thiab cov kab mob muaj feem cuam tshuam tsawg los ntawm cov kab mob tiv taus:

S ≤ 2 mg / L thiab R> 2 mg / L.

Qhov ntau ntawm cov kis tau kuj yuav txawv rau qee hom nyob ntawm thaj av ntawm thaj chaw thiab dhau sijhawm, thiab nws yog qhov tsim nyog kom muaj cov ntaub ntawv ntawm thaj av ntawm cov xwm txheej ntawm kev nthuav dav ntawm qhov tsis kam, tshwj xeeb hauv kev kho mob ntawm kev sib kis mob hnyav. Cov ntaub ntawv no tsuas yog kwv yees lub tswv yim ntawm qhov muaj feem ua rau muaj kev phom sij rau cov tshuaj tua kab mob no.

Gram-zoo cocci, suav nrog:

-Streptococcus tsis koom nrog ib pawg twg

Gram-negative bacilli, suav nrog:

Gram tsis zooaerobiccov kab mob

-Tsis-fermentinggram tsis zoobacilli

Clindamycin qhia pom kev ua ub no hauv vitro thiab hauv vivo tawm tsam Toxoplasma gondii.

* Feem ntau ntawm cov kabmob methicillin tiv thaiv yog kwv yees li 30 mus rau 50% rau txhua tus staphylococci thiab raug soj ntsuam feem ntau hauv tsev kho mob.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj yog siv sab hauv, txhawm rau kom tsis txhob khaus ntawm txoj hlab pas, lub tsiav tshuaj yuav tsum tau muab ntxuav nrog ib khob dej (250 ml).

Kev noj tshuaj ib txwm ib hnub yog 600-1800 mg / hnub, muab faib ua 2, 3 lossis 4 koob tshuaj sib npaug. Qhov siab tshuaj ntau tshaj txhua hnub yog 2400 mg.

Kev saib xyuas cov menyuam yaus

Tsuas tshuaj ntawm 8-25 mg / kg ib hnub twg, muab faib ua 3 lossis 4 koob tshuaj sib npaug.

Siv rau cov menyuam yaus yog qhov qhia tau yog tias lawv tuaj yeem nqos tag nrho cov tshuaj ntsiav.

Cov neeg laus cov neeg mob

Pharmacokinetic cov kev tshawb fawb tom qab qhov ncauj los yog kev tswj hwm ntawm clindamycin tsis qhia txog qhov sib txawv tseem ceeb ntawm cov tub ntxhais hluas thiab cov neeg laus uas lub siab ua haujlwm thiab lub cev tsis zoo (coj mus rau hauv lub hnub nyoog) lub raum ua haujlwm. Hauv qhov no, kev hloov kho koob tshuaj rau cov neeg mob laus uas lub siab ua haujlwm thiab li qub (noj rau hauv lub hnub nyoog ua haujlwm) lub raum tsis ua haujlwm.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Hauv cov neeg mob uas lub raum tsis txaus, yuav tsum tau txhaj tshuaj los ntawm clindamycin tsis yog yuav tsum tau ua.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Hauv cov neeg mob uas muaj daim siab tsis txaus, tshuaj kho tus mob clindamycin tsis tas yuav ua haujlwm.

Koob tshuaj rau cov kev qhia tshwj xeeb

Kev Kho Mob rau Beta Hemolytic Streptococcus Infections

Cov koob tshuaj pom zoo sib haum rau cov koob tshuaj saum toj no rau cov neeg laus thiab menyuam yaus. Txoj kev kho yuav tsum txuas txuas ntxiv tsawg kawg 10 hnub.

Kev kho mob ntawm tus mob streptococcal tonsillitis lossis pharyngitis

Qhov koob tshuaj pom zoo yog 300 mg ob zaug ib hnub rau 10 hnub.

Kev kho tus neeg mob rau cov mob ua mob rau ntawm lub plab (pelvic)

Cov kev kho mob yuav tsum tau pib nrog kev daws teeb meem nrog Dalacin C Phosphate (ntawm koob tshuaj 900 mg txhua 8 teev nyob rau hauv kev sib xyaw nrog cov tshuaj tua kab mob nrog qhov ntsuas qhov tsim nyog ntawm kev txiav txim siab tiv thaiv gram-negative aerobic microorganisms, piv txwv li, nrog gentamicin ntawm koob ntawm 2.0 mg / kg, tom qab ntawd koob tshuaj 1.5 mg / kg txhua 8 teev hauv cov neeg mob uas lub raum tsis ua haujlwm). Kev tswj hwm cov tshuaj tiv thaiv yuav tsum txuas ntxiv tsawg kawg 4 hnub thiab tsawg kawg 48 teev tom qab tus neeg mob tus mob zoo dua.

Tom qab ntawd, koj yuav tsum tau noj cov tshuaj Dalacin® ntxiv ntawm qhov ncauj ntawm 450-600 mg txhua 6 teev txhua hnub mus txog thaum ua tiav chav kho mob nrog tag nrho lub sijhawm 10-14 hnub.

Pob txha thiab mob sib kis

Qhov koob tshuaj pom zoo yog 7.5 mg / kg txhua 6 teev.

Kev tiv thaiv ntawm endocarditis nyob rau hauv cov neeg mob uas penicillin rhiab heev

Hauv cov neeg mob cov neeg laus, cov koob tshuaj pom zoo yog 600 mg 1 teev ua ntej kev ua tiav; cov menyuam yaus: 20 mg / kg 1 teev ua ntej txheej txheem.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Dalacin muaj nyob hauv cov ntawv hauv qab no:

• Nkag rau siv sab nraud 1%: pob tshab, xim tsis muaj xim, muaj viscous (30 g txhua tus hauv cov hlab, 1 raj hauv pob ntawv qhwv),,
• Vaginal lee 2%: dawb (20 lossis 40 g txhua hauv cov hlab ntawm polyethylene lossis txhuas ntawv ci ua tiav nrog 3 lossis 7 cov neeg thov (feem), 1 teeb hauv ib daim ntawv thawv),,
• Cov tshuaj ntsiav: gelatinous, tawv tawv, nrog lub cev thiab lub hau dawb, sau npe "P&U 225" (150 mg txhua) lossis "P&U 395" (300 mg ib qho twg), cov ntsiab lus ntawm cov tshuaj ntsiav yog hmoov dawb (8 lossis 10 pcs.) Hauv cov hlwv, 2 lossis 10 lub hlwv hauv lub thawv ntawv thawv),
• Vaginal suppositories: torpedo-puab, khoom, nrog tus du, yuav luag dawb los yog dawb (3 pcs. Hauv cov ntawv ci ntawm cov ntawv ci laminated nrog lossis tsis muaj tus neeg thov khoom, 1 kab ntawv hauv pob ntawv qhwv).

Kev Koom Tes ntawm 1000 mg gel rau kev siv sab nraud:

• Cov tshuaj kom nquag plias: clindamycin (hauv daim ntawv ntawm ntsev) - 10 mg,
• Ntu cov khoom siv: methyl paraben - 3 mg, allantoin - 2 mg, polyethylene glycol - 100 mg, propylene glycol - 50 mg, carbomer 934P - 7.5 mg, ib qho kev daws 40% sodium hydroxide - hauv qhov ntau txaus, cov dej huv - hauv qhov ntau txaus txog 1000 mg Cov.

Kev sib xyaw ntawm 1000 mg rau lub paum noj:

• Cov tshuaj nquag: clindamycin (hauv daim ntawv ntawm phosphate) - 20 mg,
• Ntu cov khoom siv: cetyl palmitate - 32.1 mg, stearic acid - 21,4 mg, polysorbate 60 - 50 mg, sorbitan monostearate - 20 mg, propylene glycol - 50 mg, benzyl cawv - 10 mg, cetostearyl cawv - 32,1 mg, ntxhia roj - 64,2 mg, dej huv - hauv qhov ntau txaus.

Muaj pes tsawg leeg 1 tshuaj ntsiav:

• Cov tshuaj kom nquag plias: clindamycin (hauv daim ntawv ntawm hydrochloride) - 150 lossis 300 mg,
• Ntu cov khoom siv: talc, lactose, pob kws nplej siab, magnesium stearate, gelatin, titanium dioxide.

Txheej Txheem 1 lub paum ntawm lub chaw mos:

• Cov tshuaj kom nquag: clindamycin (hauv daim ntawv ntawm phosphate) - 100 mg,
• Lub Cheebtsam cov khoom siv: cov roj ua kom tsis muaj rog (Witepsol H-32, kev sib xyaw ntawm monoglycerides, diglycerides thiab triglycerides) - txog 2400 mg.

Cov Yuav Tsum Tau Ua

Dalacin yog contraindicated nyob rau hauv lub xub ntiag ntawm hypersensitivity rau clindamycin, lincomycin los yog ntu Cheebtsam ntawm cov tshuaj.

Cov tshuaj nyob rau hauv daim ntawv ntawm tsiav tshuaj yuav tsum tau noj nrog ceev faj nyob rau hauv cov neeg mob nrog lub plab zom mov (keeb kwm), tshwj xeeb tshaj yog nrog ulcerative mob plab, myasthenia gravis (tej zaum yuav ua tsis tau neuromuscular kis), mob siab heev tsis ua hauj lwm.

Tsis tas li ntawd, Dalacin hauv lwm cov tshuaj muab tshuaj yog contraindicated nyob rau hauv cov kab mob / mob li nram no:

• Keeb kwm hais txog tshuaj tua kab mob sib kis,
• Lub hnub nyoog: txog 18 xyoo rau cov tshuaj pleev qhov ncauj thiab cov tshuaj tiv thaiv kab mob, nce mus txog 12 xyoo rau kev siv gel rau kev siv sab nraud (tsis muaj ntaub ntawv qhia txog kev ua tau zoo thiab kev nyab xeeb ntawm Dalacin hauv pawg neeg mob no),
• Kev tsis haum rau lincomycin lossis clindamycin hauv anamnesis (rau gel rau kev siv sab nraud).

Tsuas tshuaj thiab tswj hwm

Dalacin hauv tshuaj ntsiav yog noj ntawm qhov ncauj. Txhawm rau kom zam dhau qhov kev nyuaj, nws raug nquahu kom siv nws nruj raws li kws kho mob tau hais tseg.

Txhawm rau kom tsis txhob khaus ntawm cov leeg hnoos qeev ntawm txoj hlab pas, tshuaj ntsiav yuav tsum tau noj nrog dej puv khob.

Cov tshuaj feem ntau noj:

• Cov neeg laus: 600-1800 mg ib hnub, ntau zaus ntawm kev tswj hwm - 2-4 zaug (hauv kev sib luag),
• Cov menyuam yaus: 8-25 mg / kg ntawm lub cev qhov hnyav hauv ib hnub, qhov ntau zaus ntawm kev tswj hwm yog 3-4 zaug (hauv kev sib npaug).

Hauv kev kho mob los ntawm kev mob tshwm sim los ntawm beta-hemolytic streptococcus, Dalacin yog siv nyob rau hauv cov koob tshuaj tau piav qhia saum toj no. Lub sijhawm ntawm kev kho kom zoo yog tsawg kawg 10 hnub.

Kev kho mob ntawm cov kab mob sib kis thiab mob ntawm lub plab hu ua pib nrog kev tswj hwm ntawm clindamycin, ntawm koob tshuaj 900 mg txhua 8 teev, ib txhij nrog cov tshuaj tua kab mob haum tsawg kawg 4 hnub. Tom qab tus neeg mob lub mob zoo dua, kev kho mob txuas ntxiv mus yam tsawg 2 hnub ntxiv, tom qab ntawd Dalacin tau xaj tshuaj rau hauv tsiav tshuaj hauv ib koob ntawm 450-600 mg. Qhov tshuaj no tau coj mus noj txhua txhua 6 teev. Tag nrho cov chav kho mob yog 10-14 hnub.

Raws li cov pov thawj, Dalacin tau sau tseg:

• Toxoplasmosis encephalitis hauv cov neeg mob AIDS: nyob rau hauv kev tsis txaus siab rau kev kho mob tus qauv, cov tshuaj yog coj ib txhij nrog pyrimethamine raws li cov txheej txheem hauv qab no: Dalacin - 600-1200 mg txhua 6 teev rau 14 hnub, tom qab ntawd 300-600 mg nrog tib zaus ntawm kev siv, pyrimethamine - txhua hnub 25 -75 mg. Raws li txoj cai, txoj kev kho mob yog 8-10 lub lis piam. Thaum siv pyrimethamine ntau dua nyob rau hauv ntau dua, 10-20 mg ntawm folic acid tauj ib hnub yuav tsum tau kho,
• Cov kab mob ncauj tsev menyuam mob tshwm sim los ntawm Chlamydia trachomatis: 450-600 mg txhua hnub, noj 4 zaug hauv ib hnub, kho mob ntev 10-14 hnub,
• Cov mob raptococcal pharyngitis / tonsillitis: rau 10 hnub, 300 mg 2 zaug ib hnub,
• Pneumocystis mob ntsws nyob rau hauv cov neeg mob AIDS: rau 21 hnub, 300-450 mg txhua 6 teev ib txhij nrog primaquine, 15-30 mg ib hnub ib zaug,
• Malaria: cov laus - 10-20 mg / kg ib hnub, menyuam - 10 mg / kg ib hnub. Cov tshuaj no tshwm sim hauv cov koob tshuaj sib npaug txhua 12 teev twg, lub sijhawm ua haujlwm yog 7 hnub. Nws tseem tuaj yeem siv Dalacin tib lub sijhawm nrog quinine (txhua 12 teev ntawm 12 mg / kg) lossis chloroquine (txhua 24 teev ntawm 15-25 mg), lub sijhawm kawm yog 3-5 hnub.

Rau kev tiv thaiv ntawm endocarditis nyob rau hauv cov neeg mob uas lub siab tsis txaus rau penicillins, Dalacin tau sau tseg: rau cov neeg laus - 600 mg, rau cov menyuam yaus - 20 mg / kg. Cov tshuaj yuav tsum tau noj 1 teev ua ntej kev kho mob me me hauv kev kho hniav lossis kev phais mob, lossis lwm yam txheej txheem uas muaj qhov pheej hmoo ua rau mob endocarditis.

Cov neeg laus uas lub raum thiab lub cev ua haujlwm zoo rau lub hnub nyoog muab rau, nrog rau cov neeg mob uas muaj lub siab ua haujlwm ntawm lub siab thiab lub raum, yuav tsum tsis txhob hloov cov tshuaj.

Hauv kev kho tus kab mob vaginosis, feem ntau yog hais txog:

• Vaginal lee: 5000 mg ntawm cream (1 tus neeg thov tag nrho, kwv yees li 100 mg ntawm clindamycin) yuav tsum tau muab ntxig rau hauv qhov chaw mos. Cov txheej txheem ua tau zoo tshaj plaws ua ntej mus pw. Kawm kom ntev - 3 lossis 7 hnub,
• Lub paum ntawm cov paum me me: 1 lub tshuaj tiv thaiv yog muab intravaginally 1 zaug nyob rau ib hnub, nyiam dua ua ntej yuav mus pw. Txoj kev kawm ntev li 3 hnub.

Dalacin nyob rau hauv daim ntawv ntawm ib qho gel yog siv rau sab nraud hauv kev kho mob ntawm pob txuv vulgaris. Cov tshuaj siv rau hauv ib txheej nyias mus rau thaj chaw (qhuav, huv tawv). Kev ua ntau yam ntawm kev siv - 2 zaug ib hnub. Qhov kev pom zoo kom ntev yog 6-8 lub lis piam. Raws li kev qhia, kev siv Dalacin yog ua tau rau 6 lub hlis. Yog tias, tom qab siv cov gel rau ntau lub hlis, cov hauj lwm zoo ntawm kev kho mob tsawg dua, ib qho so yog yuav tsum tau 4 lub lis piam.

Sab sij huam

Thaum siv Dalacin sab hauv, cov kev mob tshwm sim hauv qab no tuaj yeem tsim:

• Cov kab mob hauv lub plab: xeev siab, mob plab, mob hlab pas, raws plab thiab ntuav, pseudomembranous mob plab, mob plab, mob rau lub plab, daj ntseg, dysbiosis, mob siab, nrog rau hyperbilirubinemia,
• Hematopoiesis (hematopoietic system): cov xwm txheej ntawm eosinophilia ntawm qhov xwm txheej dhau los thiab leukopenia (neutropenia), nrog rau cov xwm txheej ntawm thrombocytopenia thiab agranulocytosis, tau sau tseg, txawm li cas los xij, tsis muaj kev sib txuas ntawm cov thawj coj ntawm Dalacin thiab cov xwm txheej no.
• Kev tsis haum tshuaj: pruritus, urticaria, maculopapular tawm pob, feem ntau feem ntau ua haujlwm raws li mob qhua pias ua pob ntawm mob nyav thiab mob me, tsis tshua muaj - kab mob vesiculobulous thiab exfoliative dermatitis, tshuaj lom epidermal necrolysis, erythema multiforme, anaphylactoid,
• Lwm yam: vaginitis.

Tsis tas li ntawd thaum kho, cov kev mob tshwm sim tom qab no: kev txhim kho superinfection, tsis hnov ​​lus ntawm neuromuscular kis.

Thaum kho tus kab mob vaginosis nrog Dalacin ua hom tshuaj pleev thiab kev pab txhawb nqa, nws muaj peev xwm los tsim kev cuam tshuam los ntawm qee cov kab ke hauv lub cev:

• Cov kab mob deev: vulvovaginitis, mob paum ntawm qhov chaw mos, mob tawm ntawm lub tsev menyuam, ua xua ntawm lub paum ntawm lub paum thiab qhov chaw mos, mob voos, trichomonas vaginitis, mob rau lub paum, yug menyuam tsis meej, poj niam lub cev tsis txaus, pojniam tawm chaw mos, endometriosis,
• Cov kab mob hauv lub cev: mob txeeb zig, mob ua paug, proteinuria,
• Cov kab mob hauv lub cev: saj tsis meej, tsis meej pem, xeev siab, raws plab, ntuav, dyspepsia, cem quav, halitosis, mob plab, cuam tshuam,
• Daim tawv nqaij: erythema, khaus, tawm pob, ua pob ntawm daim tawv nqaij, maculopapular pob, urticaria,
• Nruab nrab hauv lub paj hlwb: kiv taub hau, mob taub hau, mob siab,
• Cov tshuaj endocrine: hyperthyroidism, glucosuria,
• Kab mob ntsws: mob ua pa sab saud, ntswg,
• Lub cev tag nrho: cov kab mob fungal, cov kab mob sib kis, tsam plab, hauv zos thiab / lossis dav dav mob plab, qis dua mob plab, mob plab, txhawm rau cov txiaj ntsig ntawm cov kev soj ntsuam microbiological los ntawm cov cai, mob rov qab, kev tsis haum,
• Cov tshuaj tiv thaiv hauv zos: o ua kom tawv nqaij o thiab khaus ntawm qhov chaw txhaj tshuaj.

Thaum ua ntawv thov lub gel rau kev siv sab nraud, cov kev mob tshwm sim hauv qab no:

• Cov kab mob hauv plab: colitis, mob plab, pseudomembranous colitis, mob plab tsis ua hauj lwm (xeev siab, raws plab, ntuav),
• Lub cev ntawm lub zeem muag: hlawv qhov xav ntawm qhov muag,
• Kev sib xyaw: feem ntau - tawv nqaij qhuav, nce ntau lawm cov qog sebaceous, ua pob khaus tawv nqaij, tso zis, hu rau dermatitis,
• Lwm yam: folliculitis tshwm sim los ntawm cov paj ntoo-tsis zoo.

Cov lus qhia tshwj xeeb

Nrog rau kev tsim kho mob plab zom mov tom qab thov Dalacin qhov ncauj los yog intravaginally, kev muaj peev xwm tsim muaj pseudomembranous mob plab yuav tsum xav txog. Tus mob kuj tuaj yeem tshwm sim li 2-3 lub lis piam tom qab tsis kho los ntawm kev kho. Nws cov tsos mob tseem ceeb muaj xws li: raws plab, mob leukocytosis, ua npaws, mob plab (qee zaum nrog tso quav thiab cov ntshav nrog quav). Yog tias tsim nyog, kev kuaj mob thiab kev kho mob yuav tsum tau ua.Nrog rau kev siv sab nraud ntawm cov tshuaj, cov mob ntawm colitis yog qhov tsis tshua muaj, txawm li cas los xij, yuav tsum tau saib xyuas thiab thaum muaj mob vwm los yog mob raws plab ntev, yuav tsum siv lub ntsej muag tawm.

Txog kev kho mob rau ncauj tsev menyuam los ntawm Chlamydia trachomatis, tshuaj ntsiav monotherapy nrog Dalacin zoo rau kev kho kom tiav.

Thaum noj cov tshuaj Dalacin sab hauv, kev loj hlob ntau ntawm cov kab mob me me ua rau cov tshuaj muaj peev xwm ua tau, tshwj xeeb tshaj yog cov poov xab-zoo li fungi. Nyob rau hauv kev txiav txim siab superinfection, nyob ntawm qhov chaw mob, qhov ntsuas tsim nyog yuav tsum tau ua.

Clindamycin yuav tsum tsis txhob raug kho rau kev kho mob daim phiaj qhwv hlwb.

Thaum sau daim ntawv tshuaj Dalacin hauv kev txhaj tshuaj ntau, koj yuav tsum tswj hwm qhov concentration ntawm clindamycin hauv cov ntshav ntshav. Nrog kev kho ntev, kev kuaj raum thiab siab ua haujlwm yuav tsum ua.

Cov kab mob hauv qab no yuav tsum tau muab cais tawm ua ntej sau cov tshuaj Dalacin rau kev kho tus mob vulvovaginitis: Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, Neisseria gonorrhoeae thiab Herpes simplex virus.

Nws yuav tsum tau yug los rau hauv lub siab tias kev siv tshuaj intravaginal tuaj yeem ua rau nce kev loj hlob ntawm cov kab mob me me rau qhov kev txiav txim, tshwj xeeb tshaj yog cov poov xab zoo li fungi.

Nrog kev siv tshuaj intravaginal, kev sib daj sib deev yuav tsum raug zam, nrog rau kev siv ntawm lwm hom khoom muab tshuaj intravaginally (piv txwv, koob txhaj tshuaj, tampons).

Tsis txhob siv cov Dalacin hauv daim ntawv ua qab zib lossis noj tshuaj pab kom sov thaum lub caij coj khaub ncaws tsis pom zoo. Thaum pib ntawm kev kho mob nyob rau hauv cov ntaub ntawv no yuav tsum tau muab ncua kom txog thaum kawg ntawm kev coj khaub ncaws.

Dalacin muaj cov khoom siv uas cuam tshuam rau lub zog ntawm cov roj hmab los yog cov khoom lag luam tawv (tshuaj tiv thaiv poj niam lub paum, cov hnab looj qau). Kev siv cov khoom lag luam zoo li no thaum kho thiab tsis pub dhau 3 hnub tom qab kev siv cov tshuaj tsis pom zoo.

Zam kev tiv tauj nrog cov gel rau kev siv rau sab nraud rau ntawm cov kab xoos ntawm lub qhov ncauj thiab qhov muag. Tom qab siv cov tshuaj, ntxuav koj txhais tes kom huv. Thaum raug mob sib kis nrog thaj chaw rhiab (ua pob rau ntawm daim tawv nqaij, ob lub qhov muag, lub qhov txhab tsis huv), yaug kom huv nrog dej txias.

Yeeb tshuaj sib cuam tshuam

Clindamycin yuav tsum tsis txhob noj tshuaj nyob rau tib lub sijhawm xws li erythromycin thiab chloramphenicol.

Muaj khaub lig-tsis kam ntawm microorganisms rau lincomycin thiab clindamycin.

Clindamycin yuav tsum siv nrog ceev faj hauv cov neeg mob tau txais lwm cov teeb meem mob leeg.

Nrog kev siv tib lub sijhawm ntawm Dalacin sab hauv nrog opioid (narcotic) analgesics nrog lub hauv nruab nrab cov nyhuv ua pa ntawm txoj hlab ua pa, qhov kev txhim kho ntawm cov lus tshaj tawm ua pa nyuaj siab mus rau apnea yog ua tau.

Txoj kev pheej hmoo ntawm kev tsim mob pseudomembranous mob thuv nce nrog kev siv tib lub sijhawm ntawm Dalacin nrog cov tshuaj tiv thaiv kab mob uas ua rau txo plab hnyuv plab.

Cov kab mob antimicrobial spectrum ntawm clindamycin tau nthuav dav los ntawm aminoglycosides.

Kev siv txau siv cov paum cov paum thiab cov tshuaj ntxiv nrog rau lwm cov tshuaj rau kev tswj hwm intravaginal tsis pom zoo.

Cov Lus Teb ntawm Dalacin yog: Klindatsin, Klindes, Klindamitsin, Klindovit, Klindatop.

Lub kaus poom Dalacin C

Tus nqi ntawm tsiav tshuaj - los ntawm 1324 p.

Cov tshuaj ntsiav muaj talc, lactose thiab magnesium stearate ua cov khoom ntu pabcuam. Lub plhaub siv cov hmoov txhuv nplej siab, titanium dioxide thiab gelatin.

Qhov thib ib yog tsiav tshuaj. Lawv tuaj yeem yog qhov hnyav ntawm 150 lossis 350 mg. Cov tshuaj ntsiav yog qhov ua tau zoo, cov xim ntawm lub cev thiab lub hau yog xim paj lossis dawb, cov xim ntawm cov hmoov uas muaj nyob sab hauv yog dawb.

Kev daws rau kev txhaj tshuaj

Tus nqi ntawm Dalacin C nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj yog los ntawm 587 r ib ampoule.

Hauv kev daws rau kev txhaj tshuaj, cov tshuaj ntxiv yog dej rau txhaj tshuaj, disodium edetate, benzyl cawv.

Ampoules tuaj yeem muaj 2, 4 lossis 6 ml ntawm cov tshuaj. Cov kua suav tsis muaj xim. Nws yog nyob rau hauv cov thawv ua los ntawm cov iav tsis muaj xim ntawm chav kawm I.

Sib cuam tshuam nrog lwm txoj kev

Cov lus qhia rau cov tshuaj hais tias nws tuaj yeem cuam tshuam cov pharmacokinetics ntawm lwm yam tshuaj.

Yog li, nws muaj peev xwm los txhim kho cov nyhuv ntawm cov leeg ua kom lub zog ntawm lub cev. Yog li, kev siv cov tshuaj no ib txhij ua ke los ntawm kev saib xyuas ntawm tus kws kho mob nruj. Qhov ntau npaum ntawm ob qho tshuaj tau muab hloov kho ib tus zuj zus.

Yog tias koj siv cov tshuaj tiv thaiv kev tiv thaiv mob raws plab thiab Dalacin C tib lub sijhawm, ces kev pheej hmoo ntawm colitis nce.

Nws yog txwv tsis pub siv cov khoom, cov lus qhia uas tau sib tham hauv tsab xov xwm, hauv kev sib xyaw nrog calcium gluconate, barbiturates, erythromycin, aminophylline, ampicillin, magnesium sulfate.

Sab sij huam

Thaum noj tshuaj, ntau yam tsis zoo txaus siab tuaj yeem tshwm sim.

Kev kho mob nrog cov tshuaj tua kab mob no tuaj yeem ua rau:

• Mob plab
• Xeev siab thiab ntuav
• Zawv plab
• Txoj hlab pas
• Dysbacteriosis
• Thrombocytopenia
• Leukopenia
• Agranulocytosis
• Eosinophilia
• Vag kis
• Cov tawv nqaij ua pob, khaus, thiab khaus
• Lub cev tsis muaj zog
• Kiv taub hau
• Apnea
• Ntshav siab

Nrog kev siv ntev ntawm cov tsiav tshuaj, txoj hlab pas yuav tshwm sim.

Tsawg tsawg zaus, cov tshuaj tua kab mob tuaj yeem ua rau qaug tshuaj lom neeg mob lom lom.

Kev tsis haum tshuaj rau qhov tshuaj tshwm sim tuaj yeem ua qhov tsis pom kev zoo.

Koj tuaj yeem kawm paub ntau ntxiv txog yuav ua li cas koj thiaj txwv tsis pub raws plab hauv tsab xov xwm: tiv thaiv mob raws plab.

Noj ntau dhau

Cov uas noj ntau tshaj tsis sau npe.

Txawm li cas los xij, yog tias koj tsis ua raws li cov tshuaj, qhov kev pheej hmoo ntawm anaphylactic poob ntau heev. Txhawm rau tshem tawm nws, antihistamines thiab glucocorticoid tshuaj siv, ntxiv rau adrenaline. Qhov ua tau zoo ntawm hemodialysis thaum muaj teeb meem kev xav ntawm anaphylactic yog xoom. Tsis muaj ib qho tshuaj tua kab mob tshwj xeeb rau cov tshuaj yeeb yam ua dej num Dalacin C.

Cov lus thiab cov xwm txheej ntawm kev cia

Cov kev qhia ntawm cov tshuaj hais tias koj yuav tsum tau muab tso rau hauv qhov chaw tsaus ntuj nrog cov av noo. Kev cia khoom kub thiab txias yuav tuaj txog 15 txog 25 degrees Celsius.

Txee lub neej nyob rau hauv daim ntawv tshuaj ntsiav yog 60 lub hlis.

Cov tshuaj nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj tuaj yeem siv rau 24 lub hlis txij li hnub ntawm kev tsim khoom.

Akrikhin OJSC (RF) lossis Pharmaprim LLC (Moldova)
Nqi - txij 207 r

Cov tshuaj nquag yog tib yam li cov tshuaj hauv cov lus nug. Muaj nyob rau hauv daim ntawv ntawm chaw mos pab txhawb nqa lossis qab zib.

Pros:

• Zoo dua rau cov kab mob ua paug vaginosis, vim nws tau thov pleev
• Cream yog ib hom uas yooj yim rau kev thov.

Cons:

• Kev siv cov suppositories tsis yooj yim rau txhua tus
• Tsis muaj nyob hauv daim ntawv foos.

Clindamycin

Nizhpharm (Serbia)
Nqi - txij 167 r

Cov tshuaj nquag yog tib yam tshuaj lom neeg. Muaj nyob hauv daim ntawv tshuaj ntsiav.

Pros:

• Daim ntawv muab cov tshuaj noj (tshuaj ntsiav) yog qhov yooj yim siv.
• Tus nqi yog tsawg.

Cons:

• Contraindicated nyob rau hauv cev xeeb tub
• Cov kev mob tshwm sim ib yam li Dalacin C.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, cov neeg laus: 150 mg txhua 6 teev, hauv kev kis mob hnyav, ib koob tshuaj muaj peev xwm nce ntxiv rau 300-450 mg ntawm cov tshuaj. Cov menyuam yaus: 8-25 mg / kg / hnub (nyob ntawm ntau qhov kis tus mob), muab faib ua 3-4 zaug.

Hauv kev kho mob ntawm colpitis tshwm sim los ntawm Chlamydia trachomatis, 450 mg tau sau tseg 4 zaug hauv ib hnub rau 10-14 hnub.

Hauv / m lossis hauv / hauv: cov laus - 300 mg 2 zaug ib hnub. Txog rau cov mob loj tsawv - 150-300 mg 2-4 zaug ib hnub, rau cov muaj mob hnyav - 1.2-2.7 g / hnub rau 2-4 txhaj. Nrog rau cov kab mob ua rau txo lub neej, kev siv tshuaj tiv thaiv iv yuav nce tau nce mus rau 4.8 g / hnub.

Cov menyuam raug xaj 10-40 mg ntawm tshuaj / kg / hnub, muab faib ua 3-4 koob.

Rau kev tswj hwm iv, dilute mus rau qhov kev txiav txim siab tsis tshaj 6 mg / ml, qhov kev siv tshuaj diluted raug tswj hwm iv hauv dej nrog li 10-60 feeb.

Dilution lub sijhawm thiab sijhawm ntawm kev lis ntshav: koob tshuaj, ntau qhov hnyav thiab lub sijhawm ntawm infusion (feem): 300 mg - 50 ml - 10 min, 600 mg - 100 ml - 20 min, 900 mg - 150 ml - 30 min, 1200 mg - 200 ml - 45 feeb Kev qhia ntau tshaj ntawm 1.2 g thaum 1 teev ntawm Txoj kev lis ntshav tsis pom zoo.

Qhov kev daws teeb meem yog siv hauv 24 teev los ntawm hnub npaj. Hauv kev kho mob colitis tshwm sim los ntawm Clostridium difficile, tam sim ntawd ua ke tswj hwm nrog vancomycin rau 10 hnub ntawm 500 mg - 2 g ib hnub, muab faib ua 3 lossis 4 koob tshuaj sib luag.

Cov neeg mob uas mob raum / mob siab tsis txaus yuav tsum tau mus txhaj tshuaj.

Pharmacological kev txiav txim

Antibiotic ntawm pab pawg ntawm lincosamides. Nws muaj qhov dav ntawm kev ua, bacteriostatic, khi rau 50S subunit ntawm ribosomal membrane thiab inhibits protein synthesis hauv microbial cell. Hauv kev hais txog tus naj npawb ntawm gram-zoo cocci, cov kab mob tshwm sim tau zoo. Siv tiv thaiv Staphylococcus spp. (suav nrog rau penicillinase ua tawm Staphylococcus epidermidis), Streptococcus spp. (tsis suav nrog Enterococcus spp), Kab mob Streptococcus pneumoniae, Corynebacterium diphtheriae, spore- thiab tsis-ua kom tsis muaj kev tsim cov tshuaj anaerobes, thiab microaerophilic gram-zoo cocci (suav nrog Peptococcus spp. (suav nrog Bacteroides fragilis thiab Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacter spp., Actinomyces spp.

Feem ntau cov kab mob ntawm Clostridium perfringens nkag siab zoo rau cov tshuaj, txawm li cas los xij, txij li lwm hom clostridia (Clostridium sporogenes, Clostridium tertium) tiv taus cov tshuaj, kev txiav txim siab tshuaj tua kab mob tau pom zoo rau kev kis mob los ntawm Clostridium spp.

Clinically tsis muaj txiaj ntsig tiv thaiv Mycoplasma pneumoniae, Haemophilus influenzae, Helibacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae, Ureaplasma urealyticum.

Cov kab mob sib kis los ntawm Dalacin C thiab lincomycin. Ua tau zoo nyob rau hauv kev kho mob ntawm asymptomatic diphtheria carriage (chav kawm txhua lub lim tiam ntawm txoj kev kho, qhov ncauj).