Cov Tshuaj (Repaglinide)

Qhov ncauj hypoglycemic tus neeg sawv cev. Sai sai txo cov ntshav piam thaj los ntawm kev txhawb nqa tawm ntawm insulin los ntawm kev ua haujlwm pancreatic β-hlwb. Lub tshuab kev ua haujlwm tau cuam tshuam nrog kev muaj peev xwm los tiv thaiv cov ATP-nyob rau hauv cov kab mob ntawm β-hlwb los ntawm kev ua ntawm cov receptors tshwj xeeb, uas ua rau depolarization ntawm cov hlwb thiab qhib cov calcium calcium. Raws li qhov tshwm sim, cov calcium calcium pauv ua rau cov tshuaj insulin tso tawm los ntawm β-cov hlwb.

Tom qab noj cov tshuaj repaglinide, qhov tshuaj insulinotropic rau kev noj zaub mov raug pom zoo rau 30 feeb, uas ua rau kev txo cov ntshav qabzib tsawg. Hauv nruab nrab ntawm cov pluas noj, tsis muaj qhov nce hauv insulin. Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus (tsis-insulin-tiv thaiv tsis tau), thaum noj cov tshuaj repaglinide ntawm 500 μg rau 4 mg, qhov kev cia siab-txo qis hauv cov ntshav qabzib tau sau tseg.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, repaglinide nrawm nrawm rau txoj hnyuv, thaum Cmax mus txog 1 teev tom qab kev tswj hwm, tom qab ntawd cov ntshav plawg ntawm repaglinide poob qis thiab tom qab 4 teev nws ua qis heev. Tsis muaj qhov sib txawv hauv qhov chaw kho mob hauv qhov chaw muag tshuaj ntawm repaglinide thaum noj tam sim ntawd ua ntej noj mov, 15 thiab 30 feeb ua ntej noj mov lossis hauv plab khoob.

Plasma protein khi yog ntau dua 90%.

Vd yog 30 L (uas muaj xwm yeem nrog sib faib hauv cov kua hluav taws xob intercellular).

Repaglinide yog yuav luag tag nrho cov khoom biotransformed hauv daim siab nrog rau kev tsim cov roj ntsha tsis ua haujlwm. Cov tshuaj Repaglinide thiab nws cov metabolites yog cov tawm nrog cov kua tsib, tsawg dua 8% nrog cov zis (raws li metabolites), tsawg dua li 1% nrog mob quav (tsis hloov). T1 / 2 yog li 1 teev.

Kev muab tshuaj yog muab teeb tsa ib qho zuj zus, xaiv ib koob tshuaj txhawm rau txhawm rau ua kom cov qib qabzib zoo.

Qhov pom zoo kom pib lub koob tshuaj yog 500 mcg. Ua kom cov koob tshuaj ntau dua yuav tsum tau nqa tawm tsis dhau los tom qab 1-2 lub lis piam tas li ntawm qhov kev nqus, nyob ntawm kev ntsuas ntawm cov metabolism hauv cov khoom noj kom rog.

Cov koob tshuaj ntau: ib leeg - 4 mg, txhua hnub - 16 mg.

Tom qab siv lwm cov tshuaj hypoglycemic, qhov xav kom pib siv yog 1 mg.

Noj ua ntej txhua pluas noj tseem ceeb. Qhov zoo tshaj plaws lub sijhawm ntawm kev noj tshuaj yog 15 feeb ua ntej noj mov, tab sis tuaj yeem noj 30 feeb ua ntej noj mov lossis tam sim ntawd ua ntej noj mov.

Yeeb tshuaj sib cuam tshuam

Ua kom cov txiaj ntsig hypoglycemic ntawm repaglinide yog ua tau nrog kev siv MAO inhibitors tib lub sijhawm, tsis-xaiv cov beta-blockers, ACE inhibitors, salicylates, NSAIDs, octreotide, anabolic steroids, ethanol.

Txo cov nyhuv hypoglycemic ntawm repaglinide yog ua tau nrog kev siv tshuaj ib txwm muaj kev sib deev tshuaj rau kev tswj hwm qhov ncauj, thiazide diuretics, GCS, danazole, cov thyroid hormones, sympathomimetics (thaum kho lossis tshem tawm cov tshuaj no, nws yog ib qho tsim nyog los ua tib zoo saib xyuas lub xeev ntawm cov metabolism hauv cov khoom noj).

Nrog rau kev siv sib xyaw ua ke nrog cov tshuaj uas muaj feem ntau hauv cov kua tsib, qhov ua tau ntawm kev muaj peev xwm cuam tshuam ntawm lawv yuav tsum raug txiav txim siab.

Hauv kev sib txuas nrog cov ntaub ntawv muaj nyob ntawm cov metabolism ntawm repaglinide los ntawm CYP3A4 isoenzyme, muaj peev xwm sib cuam tshuam nrog CYP3A4 inhibitors (ketoconazole, intraconazole, erythromycin, fluconazole, mibefradil), ua rau muaj kev nce ntxiv ntawm ntshav ntshav repaglinide qib, yuav tsum ua rau muaj kev cuam tshuam. Inducers ntawm CYP3A4 (suav nrog rifampicin, phenytoin), tuaj yeem txo qhov kev kub siab ntawm repaglinide hauv ntshav. Txij li cov degree ntawm induction tsis tau txhim tsa, kev siv tib txhij ntawm repaglinide nrog cov tshuaj no yog contraindicated.

Cev xeeb tub thiab lactation

Siv thaum cev xeeb tub thiab lactation yog contraindicated.

Hauv kev sim tshuaj, nws tau pom tias tsis muaj teebmeem teratogenic, tab sis thaum siv cov koob tshuaj ntau hauv cov nas nyob rau theem kawg ntawm cev xeeb tub, embryotoxicity thiab kev txhim kho ntawm cov ceg tawv hauv cov menyuam hauv plab tau pom. Cov tshuaj Repaglinide ua rau cov kua mis tawm tsis tau.

Sab sij huam

Los ntawm ib sab ntawm cov metabolism: cuam tshuam rau cov metabolism hauv cov metabolism - hypoglycemic tej yam kev mob (pallor, tawm hws ntau zog, tawm tsam, pw tsaug zog, tshee tshee), kev hloov pauv hauv cov ntshav qabzib yuav ua rau pom kev ib ntus, tshwj xeeb tshaj yog thaum pib kho mob (sau tseg rau qee tus neeg mob thiab tsis yog yuav tsum tau tshem tawm cov tshuaj).

Los ntawm lub plab zom mov: mob plab, zawv plab, xeev siab, ntuav, cem quav, qee zaum - nce kev ua si ntawm daim siab enzymes.

Ua xua: khaus, erythema, urticaria.

Yam 2 ntshav qab zib mellitus (uas tsis yog cov tshuaj insulin).

Cov Yuav Tsum Muaj

Hom 1 mob ntshav qab zib mellitus (insulin-dependant), mob ntshav qab zib ketoacidosis (suav nrog tsis nco qab lawm), mob tsis zoo rau lub raum, mob siab rau hepatic, kho tsis tau zoo nrog rau cov tshuaj uas inhibit lossis ntxias CYP3A4, cev xeeb tub (suav nrog kev npaj) , lactation, kev ua haujlwm tsis haum rau repaglinide.

Cov lus qhia tshwj xeeb

Nrog rau daim siab lossis mob raum, kev phais mob ntev ntev, kev mob lossis kab mob tsis ntev los no, qhov txo qis ntawm qhov ua tau zoo ntawm repaglinide yog tau.

Siv nrog ceev faj hauv cov neeg mob raum.

Hauv cov neeg mob debilitated lossis hauv cov neeg mob uas tsis muaj zaub mov noj tsawg, repaglinide yuav tsum tau noj nyob rau hauv qhov tsawg kawg nkaus thaum pib thiab txij nkawm cov koob tshuaj. Txhawm rau tiv thaiv hypoglycemic nyob rau hauv pawg no ntawm cov neeg mob, cov koob tshuaj yuav tsum tau xaiv nrog ceev faj.

Qhov teeb meem hypoglycemic tshwm sim feem ntau yog cov kev yoog thiab cov yooj yim nres los ntawm kev ua kom tau cov carbohydrates. Hauv cov xwm txheej hnyav, nws yuav tsim nyog rau / hauv kev qhia ntawm cov piam thaj. Qhov ntxim nyiam ntawm kev txhim kho cov tshuaj tiv thaiv yog nyob ntawm koob tshuaj, cov yam ntxwv khoom noj khoom haus, kev siv dag zog ntawm lub cev, kev ntxhov siab.

Thov nco ntsoov tias beta-blockers tuaj yeem npog cov tsos mob ntawm kev ua kom lub qog ntshav qab zib.

Thaum mus khomob, cov neeg mob yuav tsum yauv tsum tsis haus cawv, li ethanol tuaj yeem txhim kho thiab ua kom ntev li qhov cuam tshuam hypoglycemic ntawm repaglinide.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Tawm tsam keeb kwm yav dhau los ntawm kev siv repaglinide, qhov ua tau ntawm kev tsav tsheb los yog koom tes nrog lwm yam kev muaj peev xwm txaus ntshai yuav tsum raug txheeb xyuas.

Kws Tshuaj

Nws thaiv cov ATP-cov poov tshuaj tso rau hauv cov qog ua haujlwm ntawm cov kab mob ntawm lub cev los ntawm cov islet apparatus ntawm cov txiav, ua rau lawv cov depolarization thiab qhib cov calcium calcium, ua kom cov insulin nce ntxiv. Cov tshuaj insulinotropic tshwm sim hauv 30 feeb tom qab thov thiab muaj nrog cov ntshav qab zib tsawg dua thaum noj mov (qhov tsis haum ntawm cov tshuaj insulin thaum noj mov tsis nce ntxiv).

Hauv kev sim hauv vivo thiab cov tsiaj tsis tau qhia tawm mutagenic, teratogenic, carcinogenic thiab cuam tshuam ntawm kev muaj menyuam.

Kev sib txuam

Beta-blockers, ACE inhibitors, chloramphenicol, indirect anticoagulants (coumarin derivatives), NSAIDs, probenecid, salicylates, MAO inhibitors, sulfonamides, cawv, anabolic steroids - txhim kho cov nyhuv. Cov calcium calcium blockers, corticosteroids, diuretics (tshwj xeeb tshaj yog thiazide sawv daws yuav), isoniazid, nicotinic acid nyob rau hauv cov koob tshuaj loj, estrogens, suav nrog ua ib feem ntawm kev tiv thaiv qhov ncauj, phenothiazines, phenytoin, sympathomimetics, cov thyroid hormones ua rau cov nyhuv tsis muaj zog.

Noj ntau dhau

Cov tsos mob: ntshav qog ntshav qab zib (kev tshaib plab, nkees thiab qaug zog, mob taub hau, chim siab, ntxhov siab, tsaug zog, pw tsaug zog, npau suav phem, coj tus cwj pwm hloov zoo ib yam li cov pom thaum haus cawv, ua rau qaug zog ntawm kev mloog, hais lus thiab pom kev tsis meej pem, tsis meej pem, pias), xeev siab, ntuav tawm, tu cev, tawm hws txias, tsis nco qab, thiab lwm yam).

Kev Kho Mob: nrog cov ntshav qog ntshav nruab nrab, tsis muaj tus mob neurological thiab tsis nco qab - noj carbohydrates (qab zib lossis piam thaj kua) sab hauv thiab kho cov koob tshuaj lossis zaub mov noj. Hauv daim ntawv loj heev (ua kom mob, tsis nco qab, tsis nco qab lawm) - nyob rau hauv / hauv kev qhia txog 50% cov kua nplaum tom qab los ntawm txoj kev lis ntshav ntawm 10% daws kom tswj tau cov ntshav qabzib tsawg kawg yog 5.5 mmol / L.

Ceev faj txog cov tshuaj yeeb tshuaj Repaglinide

Siv nrog ceev faj hauv cov neeg mob uas lub siab los yog lub raum tsis ua haujlwm. Thaum kho, nws yog ib qho tseem ceeb uas yuav tsum tau soj qab xyuas cov qib ntawm cov piam thaj hauv cov ntshav ntawm lub plab thiab tom qab noj mov, qhov nkhaus niaj hnub ntawm kev mloog ntawm cov piam thaj hauv cov ntshav thiab zis. Tus neeg mob yuav tsum tau ceeb toom txog qhov kev pheej hmoo ntawm kev mob ntshav qab zib siab ntau thaum muaj kev ua txhaum ntawm kev noj tshuaj ntau, noj zaub mov tsis zoo, suav nrog thaum yoo mov, thaum haus cawv. Nrog rau kev tswj xyuas lub cev thiab lub siab, qhov tsim nyog yuav tau txhaj tshuaj.

Siv nrog ceev faj thaum ua haujlwm rau cov tsav tsheb thiab cov neeg uas muaj kev cuam tshuam los ntawm kev saib xyuas ntau ntxiv.

Dosage daim ntawv

Cov ntsiav tshuaj 0.5 mg, 1 mg, 2 mg

Ib ntsiav tshuaj muaj

cov tshuaj heev - repaglinide 0.5 mg, 1.0 mg, 2.0 mg,

zam txim: microcrystalline cellulose, qos yaj ywm hmoov txhuv nplej siab, calcium calcium phosphate, polacryline, povidone K-30, glycerin, poloxamer 188, magnesium lossis calcium stearate, daj hlau oxide (E 172) rau 1 mg muab tshuaj, liab hlau oxide (E 172) rau 2 mg muab tshuaj Cov.

Cov ntsiav tshuaj yog dawb lossis yuav luag dawb (rau qhov ntau npaum li cas ntawm 0.5 mg), los ntawm lub teeb daj mus rau daj (rau qhov ntau npaum li cas ntawm 1.0 mg), los ntawm lub teeb liab mus rau liab dawb (rau qhov ntau npaum li cas ntawm 2.0 mg), puag ncig, nrog thaj chaw biconvex.

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Repaglinide yog nqus tau sai sai ntawm lub plab zom mov, uas yog nrog los ntawm kev nce ntxiv hauv nws cov concentration hauv ntshav. Qhov siab tshaj plaws ntawm repaglinide nyob rau hauv cov ntshav tau tiav hauv ib teev tom qab kev tswj hwm.

Tsis muaj qhov sib txawv hauv tsev kho mob los ntawm qhov chaw muag tshuaj ntawm repaglinide thaum nws noj tam sim ntawd ua ntej noj mov, 15 feeb lossis 30 feeb ua ntej noj mov lossis hauv plab.

Lub pharmacokinetics ntawm repaglinide yog tus cwj pwm los ntawm qhov nruab nrab txog qhov nruab nrab tsis txaus ntseeg txog 63% (kev hloov pauv qhov sib txawv (CV) yog 11%).

Hauv cov kev tshawb fawb soj ntsuam, qhov kev cuam tshuam qhov siab sib txawv ntawm qhov siab (60%) ntawm plasma repaglinide concentration tau tshwm sim. Kev sib pauv ntawm ib leeg rau ib leeg yog qhov tsawg mus rau theem nrab (35%). Txij li thaum titration ntawm koob tshuaj repaglinide yog nqa tawm nyob ntawm qhov lus teb soj ntsuam ntawm tus neeg mob rau kev kho, kev hloov pauv tsis sib txawv tsis cuam tshuam rau cov txiaj ntsig ntawm kev kho.

Cov chaw muag tshuaj ntawm repaglinide yog tus yam ntxwv ntawm qhov ntim tsawg ntawm 30 l (ua raws li kev faib tawm hauv cov kua dej hauv qhov dej), nrog rau qhov kev sib txuam ntau ntawm cov tib neeg plasma protein (ntau dua li 98%).

Tom qab mus txog qhov siab tshaj (Cmax), cov ntsiab lus plasma tsawg zuj zus. Ib nrab-lub neej ntawm kev siv tshuaj (t½) yog kwv yees li ib teev. Repaglinide raug tshem tawm tag nrho los ntawm lub cev hauv 4-6 teev. Repaglinide yog qhov ua tiav tag nrho, feem ntau los ntawm CYP2C8 isoenzyme, tab sis kuj, txawm tias qee qhov tsawg dua, los ntawm CYP3A4 isoenzyme, thiab tsis muaj cov metabolites uas muaj kev cuam tshuam los ntawm lub chaw kho mob hypoglycemic tau pom.

Cov tshuaj rov ua dua tshiab yog ua rau txoj hnyuv feem ntau, thaum lub cev tsawg dua 1% ntawm cov tshuaj pom hauv cov quav tsis hloov. Ib qho me me (kwv yees li 8%) ntawm kev muab tshuaj yog pom nyob hauv cov zis, feem ntau hauv cov tshuaj metabolites.

Cov pab pawg neeg tshwj xeeb

Cov tshuaj Repaglinide tau nce rau cov neeg mob lub siab tsis ua hauj lwm thiab cov neeg laus uas muaj ntshav qab zib hom 2. AUC (SD) txiaj ntsig tom qab txhaj ib koob tshuaj 2 mg (4 mg rau cov neeg mob siab tsis ua haujlwm) yog 31.4 ng / ml x teev (28.3) hauv cov neeg tuaj yeem noj qab haus huv, 304.9 ng / ml x teev (228.0 ) hauv cov neeg mob siab tsis ua hauj lwm siab thiab 117.9 ng / ml x teev (83.8) hauv cov neeg laus uas muaj ntshav qab zib hom 2.

Tom qab 5 hnub ntawm kev kho mob nrog repaglinide (2 mg x 3 zaug hauv ib hnub), cov neeg mob uas lub raum tsis ua haujlwm loj (kev tsim teeb meem tshem tawm: 20-39 ml / min) tau pom qhov tseem ceeb 2 npaug ntawm qhov muaj nqis (AUC) thiab ib nrab-lub neej (t1 / 2 ) piv rau cov neeg mob lub raum kev ua haujlwm.

Cov Tshuaj Hauv Tshuaj

Repaglide® yog qhov ncauj tshuaj hypoglycemic ntawm kev txiav txim luv. Sai sai txo cov ntshav qabzib los ntawm kev kho los tso tawm ntawm cov tshuaj insulin los ntawm tus txiav ua kab mob. Nws khi rau the-cell daim nyias nyias nrog ib qho kev txais protein rau cov tshuaj no. Qhov no ua rau thaiv ntawm ATP-dependent potassium channel thiab depolarization ntawm lub cell membrane, uas, nyeg, pab txhawb rau qhib cov calcium calcium raws. Kev ua kom tau cov calcium nyob rau hauv the-cell ua rau lub zog tiv thaiv cov kab mob hauv insulin.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, qhov tshuaj tiv thaiv insulinotropic pom muaj nyob hauv 30 feeb tom qab kev noj tshuaj. Qhov no muab qhov ua kom cov ntshav piam thaj hauv lub sijhawm tag nrho ntawm kev noj zaub mov. Nyob rau tib lub sijhawm, theem ntawm repaglinide nyob rau hauv cov ntshav txo qis sai, thiab 4 teev tom qab noj cov tshuaj hauv plasma ntawm cov neeg mob ntshav qab zib hom 2, qhov tshuaj muaj peev xwm tsawg kawg tau pom.

Cov chaw kuaj mob tau zoo thiab Kev Nyab Xeeb

Kev tso tshuaj kom tsawg hauv cov ntshav qabzib tau pom nyob hauv cov neeg mob ntshav qab zib hom 2 nrog kev teem sij hawm ntawm repaglinide nyob rau hauv lub koob ntau li ntawm 0.5 txog 4 mg. Cov kev tshawb fawb soj ntsuam pom tau tias kev rov noj tshuaj dua yuav tsum noj ua ntej noj mov (preprandial dosing).

Kev ntsuas rau siv

- hom 2 mob ntshav qab zib mellitus nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj, yuag poob thiab kev tawm dag zog

- hom 2 mob ntshav qab zib mellitus ua ke nrog metformin hauv qhov xwm txheej tsis tuaj yeem ua kom tiav txaus siab glycemic tswj kev siv tshuaj metformin monotherapy.

Kev kho yuav tsum yog lub tswv yim ntxiv rau txoj kev kho kev noj haus thiab kev siv lub cev kom txo cov ntshav cov piam thaj.

Tsuas tshuaj thiab tswj hwm

Repaglinide raug tso tseg ua ntej. Kev xaiv koob tshuaj yog nqa tawm ntawm ib leeg ib leeg txhawm rau kom ua kom zoo glycemic tswj. Ntxiv nrog rau kev niaj hnub kuaj xyuas tus neeg mob ntshav thiab ntshav qabzib ntau dhau, kev saib xyuas ntshav qabzib yuav tsum ua los ntawm kws kho mob los txiav txim siab rau qhov muaj txiaj ntsig zoo rau tus neeg mob. Qhov kev cia siab ntawm glycosylated hemoglobin kuj tseem yog qhov ntsuas kev pom ntawm tus neeg mob cov lus teb rau kev kho. Kev tshuaj xyuas lub sijhawm ntev ntawm cov piam thaj hauv qab zib yog tsim nyog los kuaj qhov tsis txaus ntawm cov ntshav qabzib hauv thawj zaug teem sijhawm ntawm tus neeg mob nrog repaglinide nyob rau hauv cov koob tshuaj ntau kawg (uas yog, tus neeg mob tau "thawj qhov kev tawm tsam"), nrog rau tshawb xyuas qhov tsis muaj zog ntawm hypoglycemic teb rau cov tshuaj no tom qab kev kho tau zoo dhau los (ntawd yog, tus neeg mob tau "muaj kev tiv thaiv thib").

Kev tswj hwm lub sijhawm luv luv ntawm cov tshuaj repaglinide tuaj yeem tsim nyog thaum lub sijhawm hloov pauv tsis tau hloov hauv cov neeg mob ntshav qab zib hom 2, feem ntau yog kev noj haus zoo.

Qhov ntau thiab tsawg ntawm cov tshuaj yog txiav txim los ntawm tus kws kho mob nyob ntawm seb qib piam thaj hauv cov ntshav.

Rau cov neeg mob uas tsis tau ua ntej tau txais lwm yam tshuaj rau qhov ncauj hypoglycemic, qhov pom zoo kom muab ib zaug ua ntej cov zaub mov tseem ceeb yog 0.5 mg. Kev hloov ntshav koob tshuaj yog ua tawm ib zaug ib lub lim tiam lossis ib zaug txhua 2 lub lis piam (thaum tsom mus rau kev mloog zoo ntawm cov piam thaj hauv cov ntshav uas yog qhov taw qhia ntawm kev teb rau kev kho).Yog tias tus neeg mob hloov pauv los ntawm noj lwm qhov ncauj hypoglycemic tus neeg sawv cev rau kev kho mob nrog Repaglid then, ces cov koob tshuaj pom zoo ua ntej ua ntej txhua pluas noj yuav tsum yog 1 mg.

Qhov pom zoo ntau kawg koob tshuaj ua ntej noj mov tseem ceeb yog 4 mg. Qhov siab kawg rau kev txhaj tshuaj txhua hnub yuav tsum tsis pub tshaj 16 mg.

Cov kev tshawb fawb soj ntsuam hauv cov neeg mob uas laus dua 75 xyoo tsis tau ua.

Lub raum khiav tsis zoo ua tsis cuam tshuam rau qhov kev tshem tawm repaglinide. 8% ntawm kev noj ib zaug ib zaug ntawm cov tshuaj repaglinide yog ua tawm los ntawm lub raum thiab tag nrho cov ntshav ua kom tshem tawm cov khoom hauv cov neeg mob raum tsis ua haujlwm yog txo. Vim yog qhov tseeb tias insulin rhiab heev hauv cov neeg mob ntshav qab zib nce nrog lub raum tsis ua hauj lwm, ceev faj yuav tsum tau siv rau kev xaiv koob tshuaj hauv cov neeg mob ntawd.

Cov kev tshawb fawb soj ntsuam hauv cov neeg mob uas muaj lub siab ua tsis tau ua tiav.

Cov neeg mob railitated thiab debilitated

Hauv cov neeg mob debilitated thiab debilitated, qhov pib thiab kev saib xyuas cov koob tshuaj yuav tsum tau txuag. Yuav tsum tau saib xyuas thaum xaiv cov koob tshuaj kom tsis txhob muaj kev txhim kho ntawm lub qog ntshav qab zib.

Cov neeg mob uas tau txais lwm yam tshuaj rau qhov ncauj hypoglycemic

Hloov chaw ntawm cov neeg mob nrog kev kho mob nrog lwm qhov ncauj tshuaj hypoglycemic los kho nrog repaglinide tuaj yeem nqa tawm tam sim. Txawm li cas los xij, kev sib raug zoo ntawm kev txhaj tshuaj ntawm repaglinide thiab koob tshuaj ntawm lwm cov tshuaj hypoglycemic tseem tsis tau qhia tawm. Qhov pom zoo siab tshaj plaws pib siv rau cov neeg mob uas pauv mus rau repaglinide yog 1 mg ua ntej txhua pluas noj.

Cov tshuaj Repaglinide tuaj yeem kho nrog kev sib xyaw nrog metformin yog tias thaum tsis txaus saib xyuas cov ntshav qabzib ntau nyob ntawm metformin monotherapy. Hauv qhov no, cov koob tshuaj ntawm metformin tau raug tswj tseg, thiab repaglinide ntxiv yog ntxiv cov tshuaj concomitant. Qhov tshuaj thawj zaug ntawm repaglinide yog 0.5 mg noj ua ntej noj mov. Kev xaiv koob tshuaj yuav tsum tau ua raws li theem ntawm cov piam thaj hauv cov ntshav ib yam li kev kho mob monotherapy.

Qhov ua tau zoo thiab kev nyab xeeb ntawm kev kho mob nrog repaglinide rau cov neeg tsis tau muaj 18 xyoo tsis tau raug tshawb nrhiav. Tsis muaj ntaub ntawv muaj.

Repaglide® yuav tsum noj ua ntej noj mov tseem ceeb (suav nrog kev npaj ua ntej). Qhov tshuaj yog feem ntau noj hauv 15 feeb tom qab noj mov, txawm li cas los xij, lub sijhawm no tuaj yeem sib txawv ntawm 30 feeb ua ntej noj mov (suav nrog 2,3 thiab 4 pluas tauj ib hnub). Cov neeg mob uas pheej noj pluas mov (lossis nrog ib pluas noj ntxiv) yuav tsum raug qhia paub txog kev hla (lossis ntxiv) koob tshuaj txheeb ze rau cov pluas noj no.