Ncua Kev Kawm Ntawv Augmentin 400 - cov lus qhia rau kev siv
Txoj cai tua tshuaj Augmentin penicillin tshuaj rau cov neeg laus thiab menyuam yaus tib si. Nws yog tshuaj rau ntau tus kab mob. Tab sis qee zaum, cov niam hluas tsis tos rau tus kws kho mob cov lus pom zoo lossis rov ua dua, ua txhaum lawv, hloov "Augmentin 400" nrog rau tus kws kho mob tau txiav txim. Hauv qhov xwm txheej no, teeb meem yuav tshwm sim nrog kev kho qhov tseeb ntawm Augmentin 400 kev ncua rau menyuam yaus. Txhawm rau kom tsis txhob ua mob, tab sis kom tau txais txiaj ntsig tiag tiag ntawm qhov zoo thiab, feem ntau, cov tshuaj muaj txiaj ntsig, koj yuav tsum to taub qee cov subtleties.
Cov xeeb ceem ntawm kev ncua kev kawm "Augmentin 400"
Augmentin 400 yog ua raws li amoxicillin, ib qho tshuaj tiv thaiv kab mob ntau yam thiab clavulanic acid tiv thaiv amoxicillin los ntawm kev puas tsuaj.
Amoxicillin yog cov khoom tseem ceeb ntawm kev ncua kev ncua "Augmentin 400". Nws yog nws leej twg muaj bactericidal thiab tua nyhuv ntawm lub cev. Qhov tsis zoo ntawm amoxicillin yog tias nws yuav dhau los ua qee yam kab mob me. Qhov no txhais tau tias lawv cia li tso tseg tsis teb cov tshuaj. Qhov no yog qhov twg clavulanic acid los rau hauv kev ua si. Nws ua rau cov kab mob kis tsawg dua.
Amoxicillin yog tshuaj tua kab mob ntawm pawg penicillin thiab yog li ntawd zoo zam txawm tias cov menyuam yaus thiab poj niam cev xeeb tub, tshwj tsis yog qee tus neeg tsis kam txais.
Tab sis nws yuav tsum nco ntsoov tias nws, zoo li cov tshuaj feem ntau, muaj nws cov kev mob tshwm sim. Thiab tseem, nws yog contraindicated muaj phenylketonuria, zoo li hauv lub raum tsis ua haujlwm thiab mob siab.
Kev ncua Augmentin yog tsim tawm rau ntau yam mob ua pa, kab mob ntawm daim tawv nqaij, thiab cov kab mob genitourinary.
Kev ncua Augmentin tseem pab nrog osteomyelitis. Nws yog qhov zoo tshaj tawm los tiv thaiv kev kis mob thaum kev phais mob.
Yuav npaj cov kev ncua li cas "Augmentin" thiab yuav siv li cas:
- Cov tshuaj yuav tsum tau muab hliv rau hauv lub vial thiab muab cov dej rhaub. Saib xyuas! Dej yuav tsum tsis txhob kub,
- Tom ntej no, nws yuav tsum tau co kom zoo, rau qhov siab tshaj plaws ntawm kev tawg ntawm cov granules thiab tawm mus rau 4 feeb. Lub sijhawm no, txawm tias qhov me me yuav muaj sij hawm yaj.
- Tab sis yog tias koj pom tias qhov no tsis tshwm sim, ces co lub raj mis dua thiab npaj mus rau 5 feeb ntxiv.
- Tom qab ntawd koj yuav tsum ntxiv dej ntxiv rau lub cim.
- Tsuas yog tom qab no, cov tshuaj tuaj yeem txiav txim siab npaj siv.
- Kev tshem tawm tiav tuaj yeem khaws cia rau hauv tub yees - txog 7 hnub, tab sis tsis txhob khov. Tom qab 7 hnub, nws raug txwv tsis pub siv cov tshuaj no.
Thaum koj tshem tawm qhov muab tshem tawm los ntawm lub tub yees, koj yuav tsum co nws zoo thiab ncuav tus nqi raug rau hauv lub ntsuas ntsuas. Koj tuaj yeem hu cov tshuaj uas yuav tsum tau muaj nrog cov koob txhaj tshuaj.
Nco ntsoov tias txhua yam khoom koj siv yuav tsum ua kom zoo. Hauv qhov tsis muaj ib qho cia tsis txhob cia cov khoom seem ntawm kev ncua kom qhuav ntawm ib rab diav lossis koob txhaj tshuaj, thiab siv ntau zaus tsis ntxuav.
Yog tias tus menyuam tsis tuaj yeem haus cov kev ncua, piv txwv li vim tias qhov tsis hnov tsw rau nws, nws raug tso cai ntxiv ib qhov dej ntxiv. Tab sis tib lub sijhawm, koj yuav tsum haus tag nrho cov tshuaj no.
Dosage ntawm ncua kev kawm "Augmentin 400" rau cov menyuam yaus: cov lus qhia rau kev xam tus kheej
Cov hmoov ua npaj "Augmentin" tuaj yeem muas tau hauv cov chaw muag tshuaj hauv ntau cov qauv, nyob rau hauv uas cov concentration ntawm amoxicillin thiab clavulanic acid yuav txawv:
- 125 mg ntawm amoxicillin + 31.35 mg ntawm clavulanic acid,
- 200 mg ntawm amoxicillin + 28.5 mg ntawm clavulanic acid,
- 400 mg ntawm amoxicillin + 57 mg ntawm clavulanic acid.
Hauv txhua qhov teeb meem, qhov tseem ceeb muab tshuaj yog 5 ml ntawm qhov kev raug tshem tawm tiav. Tab sis koj yuav tsum paub tias kev xam ntawm qhov ntau dua ntawm Augmentin 400 ib txwm ua raws li kev saib xyuas ntawm amoxicillin: 125, 200 lossis 400. Qhov no tseem ceeb kom nkag siab thiaj li nco ntsoov tias cov tshuaj no tsis hloov ua ib leeg. Thiab yog tias koj tau muab "Augmentin 400", koj tsis tuaj yeem hloov nws nrog "Augmentin 200" lossis "Augmentin 125" thiab rov qab los.
Kev ncua sijhawm Augmentin 400 feem ntau yog tsim rau cov menyuam yaus hnub nyoog 12 xyoos thiab cov laus. Lub cev qhov hnyav ntawm cov menyuam yuav tsum ntau tshaj 40 kg. Tab sis kev noj cov me nyuam muaj 2 xyoos rov hauv yog contraindicated. Lub Augmentin 125 tsuas yog ua rau lawv.
Cov koob tshuaj ntawm ncua kev kawm "Augmentin 400" rau cov menyuam yaus yog tus kheej - nws yog qhov yuav tsum xav txog lub cev qhov hnyav, qhov mob hnyav, hnub nyoog. Qhov tshuaj tsuas yog muab suav rau amoxicillin xwb.
Yog tias cov tshuaj tau sau rau cov menyuam hnub nyoog qis dua 12 xyoos, ces nws yuav tsum ua kom ntseeg tau tias 1 kg ntawm lub cev qhov hnyav tsim tawm tsis ntau tshaj 45 mg thiab tsis pub tsawg tshaj 25 mg ntawm cov tshuaj tua kab mob.
Qhov mob hnyav heev ntawm tus kabmob kuj tseem ua txoj haujlwm loj. Piv txwv, nrog kev kis mob ntawm daim tawv nqaij, mob ua mob tonsillitis - koob tshuaj tiv thaiv kab mob - yog qhov tsawg heev. Tab sis nrog kev sib kis mob hnyav, mob ntsws, mob ntsws - txoj kev txhaj tshuaj ntau ntxiv.
Nws yog tsim nyog kom nco ntsoov tias tseem muaj tus naj npawb ntawm koob tshuaj. Piv txwv li, ib tug menyuam yaus hnub nyoog qis dua 12 xyoos tuaj yeem muab tsuas yog 1 lossis 2 p. ib hnub. Thiab qhov so nruab nrab ntawm ob qhov txais tos yuav tsum yog tsawg kawg 12 teev.
Ib qho piv txwv ntawm qhov muab xam ntawm cov tshuaj:
Tus menyuam hnub nyoog 8 xyoo, hnyav - 27 kg. Tus kab mob yog otitis media. Nws xav tau 45 mg ntawm cov tshuaj rau 1 kilogram ntawm qhov hnyav. Qhov no txhais tau hais tias qhov ntau npaum li cas ntawm cov tshuaj yuav yog 1215 mg, uas yuav muab faib ua 2 koob tshuaj - 607,5 mg txhua.
Hauv 5 ml ntawm Augmentin kev ncua - 400 mg, uas txhais tau hais tias 7.6 ml, lossis 15 ml ib hnub, yuav tsum tau ua nyob rau ib zaug.
Nws tsis yooj yim los xam qhov pes tsawg ntawm Augmentin 400 ncua kev kawm rau ib tus menyuam. Txij li koj xav tau los ua qee qhov kev ua lej. Feem ntau, cov niam txiv tau tsis meej pem hauv lawv, yog li muaj qhov nruab nrab qhov tseem ceeb. Tab sis nws zoo dua rau kev siv cov txiaj ntsig no tsuas yog ua piv txwv. Ntawd yog, kuaj xyuas lawv seb cov suav tseeb puas muaj tseeb.
Piv txwv li, tus menyuam yaus hnub nyoog dhau ib xyoos thiab hnyav txog 18 kg yuav tsum tsis txhob ntau tshaj 5 ml ntawm qhov kev ua tiav "Augmentin". Ib tug menyuam yaus hnub nyoog qis dua 6 xyoo los ntawm 19 kg tuaj yeem twb muaj 7,5 npaj ncua kev kawm. Yog tias tus me nyuam twb dhau 10 xyoo, thiab nws hnyav dua 29 kg, tom qab ntawd nws xav tau 10 ml ntawm kev ncua nyob rau ib zaug. Tab sis cov nqi no tsis xav txog tus kab mob nws tus kheej, thiab nws tsis loj heev.
Ncua Kev Kawm Ntawv Augmentin: cov neeg siv khoom tshuaj xyuas
Zoo li txhua yam tshuaj tua kab mob, Augmentin 400 muaj qee yam tsis zoo. Kev txheeb xyuas txog nws los ntawm niam txiv yog qhov muaj kev sib cav heev. Tab sis koj yuav tsum nkag siab tias kev siv tshuaj tiv thaiv kab mob yuav tsum tau noj raws li kws kho mob tau qhia thiab tsuas yog nyob hauv cov xwm txheej uas koj tsis tuaj yeem ua yam tsis muaj lawv.
Irina: “Peb siv Augmentin kev ncua rau kev mob ntsws. Hmoov tsis zoo, lwm txoj kev tsuas yog tsis pab. Tab sis peb sim siv nws ua ke nrog lwm txoj kev. Tus menyuam muaj 3 xyoos. Cov tshuaj nws tus kheej tau noj 4 hnub, ib zaug ib hnub, 5 ml. Nco ntsoov rov qab kho cov hnyuv microflora tom qab qhov no. "
Olesya: "Peb tus kws kho mob tsaj lij hais kom peb yuav cov tshuaj no -" Augmentin "thaum peb tuaj tawm tswv yim txog tonsillitis. Mus rau tus tub - 6 l. Nws tau hais txog 5 ml ntawm kev raug tshem tawm ib hnub rau 7 hnub nyob uake. Kuv txiav txim siab tias qhov no yog tus kws tshaj lij, yog li nws yuav tsum ntseeg thiab sim ua raws nraim cov lus qhia. Tab sis twb tom qab tau txais thib 1, tus tub tsim mob xeev siab, thiab tom qab tus thib 2, ntuav tshwm. Peb tau tshem tawm txoj kev kho mob. Nws txia ntshis ua tus neeg mob yam tsis tu ncua. "
Augmentin tsis yog ib qho tshuaj nyab xeeb. Cov tshuaj tua kab mob tsis nyab xeeb thiab muaj contraindications thiab phiv uas yuav tsum tau muab los xav.
Yog li, nco ntsoov noj cov tshuaj tsuas yog tom qab mus ntsib kws kho mob thiab nws cov lus pom zoo thiab ua tib zoo saib xyuas.
Tus nqi kwv yees ntawm kev ncua "Augmentin 400" yog kwv yees li 380-460 rubles. Ntau qhov tseeb, koj tuaj yeem nrhiav hauv cov khw muag tshuaj ntawm koj lub nroog.
Pharmacological kev txiav txim
Augmentin yog ib qho tshuaj tiv thaiv kom dav. Cov tshuaj nquag ntawm cov tshuaj ua rau muaj txiaj ntsig xws li tshuaj:
- Amoxicillin yog tshuaj tua kab mob ib nrab hnub uas tawm tsam cov kab mob gram-negative thiab gram-zoo. Qhov pom ntawm amoxicillin tsis ntev rau cov kab mob me me uas tsim cov beta-lactamase enzyme.
- Clavulanic acid muaj qhov ntxim rau beta-lactamases thiab tiv thaiv amoxicillin los ntawm kev puas tsuaj ua ntej los ntawm cov enzymes no. Qhov no tso cai rau koj los nthuav cov nyhuv antibacterial ntawm amoxicillin.
Cov kab mob tua kab mob rhiab rau kev sib xyaw ua ke ntawm amoxicillin + clavulanic acid:
- Cov kab mob gram-positive aerobic: bacilli, fecal enterococci, listeria, nocardia, kab mob streptococcal thiab staphylococcal.
- Cov kab mob gram-positive anaerobic: clostidia, peptostreptococcus, peptococcus.
- Cov kab mob gram-negative aerobic: hnoos txhaws qa, Helicobacter pylori, hemophilic bacilli, cholera vibrios, gonococci.
- Gram-negative anaerobic kab mob: clostridial kis mob, bacteroids.
Kev ntsuas rau siv
Qhov qhia tau rau kev noj cov Augmentin yog kev kho mob ntawm cov kab mob kis tau los ntawm cov kab mob me me uas cuam tshuam rau cov tshuaj ntawm cov tshuaj. Kev kho ntau yam ntawm cov kab mob hauv qab no:
- Kev kis mob rau ENT cov kabmob, piv txwv li, mob tonsillitis, mob ntsws, mob otitis, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhal yog thiab Streptococcus pyogenes.
- Cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, lobar mob ntsws, thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae, thiab Moraxella catarrhalis.
- Kab mob Urogenital, xws li mob cystitis, mob urethritis, pyelonephritis, kis mob rau poj niam lub cev, ua rau mob los ntawm hom kab mob Enterobacteriaceae (feem ntau Escherichia coli), Staphylococcus saprophyticus thiab hom kab mob ntawm genus Enterococcus, nrog rau tus kab mob gonorrhea los ntawm Neisseria gonorrhoeae.
- Kev kis mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus, Streptococcus pyogenes, thiab hom ntawm cov genus Bacteroides.
- Kev kis mob ntawm cov pob txha thiab pob qij txha, xws li osteomyelitis, feem ntau tshwm sim los ntawm Staphylococcus aureus, yog tias muaj kev kho mob ntev yog tsim nyog.
- Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw tseem ceeb.
Qhov rhiab ntawm cov kab mob ntawm ib tug neeg mus rau Augmentin yuav sib txawv raws tus neeg mob qhov chaw nyob. Yog tias qhov no ua tau, tom qab ntawd hauv kev tshawb nrhiav nws yog ib qho tseem ceeb uas yuav tsum coj mus rau hauv qhov chaw txheeb cais hauv zos ntawm kev nkag siab ntawm cov kab mob pathogenic.
Raws li qhov tsim nyog, tus neeg mob yuav tsum tau sim los txiav txim siab qhov rhiab ntawm cov kab mob coj mus rau cov tshuaj tua kab mob Augmentin.
"Augmentin": cov yam ntxwv dav dav ntawm cov tshuaj
Lub ntsiab ntawm Augmentin, tsis hais txog daim ntawv ntawm nws tso tawm, yog cov tshuaj tua kab mob amoxicillin thiab lactamase tshem tawm, clavulline acid. Lub luag haujlwm tseem ceeb nyob nrog amoxicillin: nws yog ua tsaug rau nws tias cov tshuaj muaj cov tshuaj tua kab mob tawm tsam yuav luag txhua qhov kis mob. Txawm li cas los xij, nws muaj teeb meem tseem ceeb - feem ntau cov kab mob muaj kab mob loj tau siv rau nws thiab nres teb, vim qhov kev tiv thaiv ntxiv uas xav tau uas yuav rhuav tshem qhov tsis kam ntawm cov kab mob. Txoj kev tivthaiv no yog clavulline acid.
- Amoxicillin yog ib feem ntawm pawg neeg penicillin thiab, feem ntau, tau pom zoo, vim li ntawd nws tuaj yeem siv rau hauv kev kho mob hauv cov menyuam yaus thiab cov pojniam xeeb tub, txawm li cas los xij, nws muaj ntau cov kev mob tshwm sim. Tsis tas li ntawd, nws tsis pom zoo rau siv rau hauv cov neeg mob phenylketonuria, lub raum tsis ua haujlwm thiab lub siab ua haujlwm tsis zoo.
Cov cim tseem ceeb rau kev tau txais kev ncua ntawm Augmentin yog:
- Cov kab mob sib kis ntawm cov pa ntawm txhua qhov kev mob, suav nrog kev rov ua dua ntawm mob mus ntev,
- Kev kis tus kab mob ntawm cov genitourinary system,
- Daim tawv nqaij mob kis los ntawm tus kab mob
- Osteomyelitis
- Kev tiv thaiv kab mob tom qab kev phais.
Yuav kom tau txais kev ncua "Augmentin" tau npaj raws li cov hauv qab no algorithm:
- Lub hmoov tau nchuav rau hauv lub raj mis, tom qab ntawd nws tau nchuav nrog sov (tsis kub!) Dej, uas yuav tsum tau muab rhaub ua ntej ntawd,
- Lub raj mis tau shaken kom cov granules yaj tau ntau li ntau tau, thiab teem sijhawm li 4-5 feeb. kom txog rau thaum cov hmoov me me ntawm cov tshuaj kom meej meej. Yog tias qhov no tsis tshwm sim, lub thawv yuav tsum tau shaken dua thiab teem cia,
- Ntxiv dej kom txaus ntshai rau sab hauv lub vial,
- Tom qab qhov no, qhov kev ncua yog npaj rau siv. Nws tuaj yeem muab khaws cia rau hauv qhov txias, yog tias tsis khov, rau 7 hnub, tab sis nws pom zoo kom siv nws hauv lub sijhawm luv luv. Nws yog txwv tsis pub siv qhov ncua ntawv rau hnub 8, txawm tias qhov muag pom nws tsis tau hloov nws lub zog,
- Ua ntej siv, lub khob ntawm cov kua yog shaken, thiab qhov ntim yam xav tau raug muab pov rau hauv lub ntsuas qhov ntsuas lossis ntim nrog cov koob txhaj tshuaj. Tom qab siv, nws yog qhov yuav tsum tau ntxuav txhua qhov ntawm cov khoom kom zoo, zam kev tsub zuj zuj ntawm cov tshuaj ntawm cov tshuaj rau saum npoo,
- Yog tias tsim nyog, nws raug tso cai kom ntuav cov kua nrog lub rhaub dej kom sib npaug hauv qhov sib txig sib luag, txawm li cas los xij, tus menyuam yuav tau haus dej ntau, thiab tsis yog ib nrab ntawm nws,
Tus nqi kwv yees ntawm kev ncua "Augmentin 400" thaj tsam ntawm 380-460 rubles.
Dosage daim ntawv
Hmoov rau kev tshem tawm qhov ncauj 400 mg / 57 mg / 5 ml, 35 ml
5 ml ntawm kev tshem tawm muaj
yam tshuaj: amoxicillin (li amoxicillin trihydrate) 400 mg,
clavulanic acid (li poov tshuaj clavulanate) 57 mg,
tus zam: xanthan ntawm cov pos hniav, aspartame, anhydrous colloidal silicon dioxide, magnesium stearate, crospovidone, croscarmellose sodium, sodium benzoate, pos nphuab tsw, anhydrous silicon dioxide.
Hmoov ntawm cov xim dawb lossis yuav luag dawb nrog cov xim daj, nrog tus yam ntxwv ntxhiab tsw. Qhov npaj ncua cia yog xim dawb lossis yuav luag dawb, thaum sawv ntsug, dej nag lossis daus dawb yuav luag maj mam tsim.
Cov chaw muag tshuaj
Farmakokinetics
Amoxicillin thiab clavulanate yaj tau zoo nyob rau hauv cov kev daws teeb meem nrog lub cev pH, sai thiab tag nrho los ntawm lub plab zom mov tom qab kev tswj hwm qhov ncauj. Kev nqus ntawm amoxicillin thiab clavulanic acid yog qhov zoo dua thaum noj cov tshuaj thaum pib noj mov. Tom qab noj cov tshuaj hauv, nws txoj kev noj qab haus huv yog 70%. Cov xaib ntawm ob qho tshuaj ntawm cov tshuaj no zoo sib xws thiab mus txog qhov siab tshaj plaws ntshav plasma concentration (Tmax) hauv thaj tsam li 1 teev. Qhov kev sib xyaw ntawm amoxicillin thiab clavulanic acid hauv cov ntshav cov ntshav yog tib yam ob qho tib si kev sib xyaw ua ke ntawm kev siv amoxicillin thiab clavulanic acid, thiab txhua feem sib xyaw.
Kev kho mob ntau ntawm amoxicillin thiab clavulanic acid yog ua tiav hauv ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg, cov kua dej interstitial (mob ntsws, plab hnyuv plab, lub zais zis, adipose, pob txha thiab cov leeg nqaij, pleural, synovial thiab peritoneal kua, tawv nqaij, bile, purulent paug, hnoos qeev). Kev siv Amoxicillin thiab clavulanic acid tsis nkag mus rau hauv cov kua dej ua kua hlwb.
Kev khi ntawm amoxicillin thiab clavulanic acid rau ntshav cov ntshav yog muaj ntsis: 25% rau clavulanic acid thiab 18% rau amoxicillin. Amoxicillin, zoo li feem ntau rau penicillins, raug tawm hauv niam cov kua mis. Ib co kua nplaum ntawm clavulanic acid kuj tau pom nyob rau hauv niam cov kua mis. Txhawm rau kev zam ntawm kev pheej hmoo ntawm kev hnov mob, amoxicillin thiab clavulanic acid tsis cuam tshuam loj rau kev noj qab haus huv ntawm cov menyuam mos uas pub niam mis. Amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv hniav.
Amoxicillin tsuas yog tawm hauv lub raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab. Tom qab cov tshuaj noj ib qhov ncauj ntawm ib ntsiav tshuaj ntawm 250 mg / 125 mg los sis 500 mg / 125 mg, kwv yees li 60-70% ntawm amoxicillin thiab 40-65% ntawm clavulanic acid raug tshem tawm tsis hloov pauv hauv cov zis thaum thawj 6 teev.
Amoxicillin yog qee cov tso tawm hauv cov zis hauv daim ntawv ntawm tsis muaj zog penicillinic acid nyob rau hauv ib qho nyiaj npaum li 10-25% ntawm cov koob tshuaj. Clavulanic acid nyob rau hauv lub cev tau dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid thiab 1-amino-4-hydroxy-butan-2-ib thiab yog tawm nrog tso zis thiab quav, ntxiv rau hauv cov qauv ntawm cov pa roj carbon dioxide los ntawm kev ua pa tawm.
Cov Tshuaj Hauv Tshuaj
Augmentin® yog cov tshuaj tua kab mob sib xyaw ua ke uas muaj amoxicillin thiab clavulanic acid, nrog rau kev pom dav ntawm cov kab mob hauv lub cev, tiv taus beta-lactamase.
Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub uas dhia tawm tsam ntau yam kab mob gram-positive thiab gram-tsis zoo. Amoxicillin raug pov tseg los ntawm beta-lactamase thiab tsis cuam tshuam rau cov kab mob me me uas tsim cov enzyme no. Cov txheej txheem ntawm kev ua ntawm amoxicillin yog rau kev txwv tsis pub lub biosynthesis ntawm peptidoglycans ntawm cov kab mob ntawm phab ntsa, uas feem ntau ua rau lysis thiab cell tuag.
Clavulanic acid yog beta-lactamate, zoo ib yam li hauv cov qauv hauv tshuaj lom rau penicillins, uas muaj peev xwm inactivate beta-lactamase enzymes ntawm cov kab mob me uas tawm tsam penicillins thiab cephalosporins, yog li tiv thaiv qhov ua tsis tiav ntawm amoxicillin. Beta-lactamases yog ua los ntawm ntau cov kab mob gram-positive thiab gram-tsis zoo. Kev ua ntawm beta-lactamases tuaj yeem ua rau muaj kev puas tsuaj rau qee yam tshuaj tua kabmob txawm tias ua ntej lawv pib cuam tshuam cov pathogens. Clavulanic acid thaiv qhov kev txiav txim ntawm cov enzymes, rov kho qhov rhiab ntawm cov kab mob mus rau amoxicillin. Hauv tshwj xeeb, nws muaj cov haujlwm siab tiv thaiv plasmid beta-lactamases, uas cov tshuaj tiv thaiv feem ntau cuam tshuam, tab sis tsis muaj txiaj ntsig tawm tsam hom 1 chromosome beta-lactamases.
Muaj cov clavulanic acid nyob rau hauv Augmentin® tiv thaiv amoxicillin los ntawm kev puas tsuaj ntawm beta-lactamases thiab nthuav nws lub zog ntawm kev ua haujlwm tiv thaiv kab mob nrog rau kev suav nrog cov kab mob me me uas feem ntau tiv taus lwm yam penicillins thiab cephalosporins. Clavulanic acid nyob rau hauv daim ntawv ntawm ib qho tshuaj tsis muaj qhov ua kom muaj kev tiv thaiv kab mob tseem ceeb.
Txhim kho txoj kev tawm tsam
Nws muaj 2 lub txheej txheem rau kev txhim kho ntawm kev tiv thaiv rau Augmentin®
- kev tsis ua haujlwm los ntawm cov kab mob beta-lactamases, uas tsis raug rau qhov cuam tshuam ntawm clavulanic acid, suav nrog cov chav kawm B, C, D
- deformation ntawm penicillin-khi protein, uas ua rau kom txo qis ntawm qhov xwm txheej ntawm cov tshuaj tua kab mob cuam tshuam nrog cov kab mob me
Lub zog tsis zoo ntawm cov kab mob phab ntsa, nrog rau cov txheej txheem ntawm lub twj tso kua mis, tuaj yeem ua rau los yog pab txhawb kev txhim kho ntawm kev tawm tsam, tshwj xeeb tshaj yog cov kab mob gram-tsis zoo.
Augmentin®muaj cov nyhuv bactericidal ntawm cov kab mob hauv qab no:
Gram-zoo aerobes: Enterococcus faecalis,Gardnerella vaginalis,Dab Tsi Staphylococcus aureus (rhiab rau methicillin), coagulase-negative staphylococci (rhiab rau methicillin), Tus kab mob Streptococcus agalactiae,Kab mob ntsws dej liab1,Cov kab mob Streptococcus pyogenes thiab lwm yam beta hemolytic streptococci, pab pawg Streptococcus viridans,Bacillius anthracis, Listeria monocytogenes, Nocardia cov hnub qub
Gram-negative aerobes: Actinobacillusactinomycetemcomitans,Capnocytophagaspp.,Eikenellacorrodens,Haemophilusmob khaub thuas,Moraxellacatarrhalis,Neisseriagonorrhoeae,Pasteurellamultocida
anaerobic microorganisms: Bacteroides fragilis,Fusobacterium nucleatum,Prevotella spp.
Cov kab mob uas muaj qhov ua tau kom tiv taus
Gram-zoo aerobes: Enterococcusfaecium*
Cov kab mob nrog lub ntuj tsis kam:
gram tsis zooaerobes:Acinetobacterhom,Citrobacterfreundii,Enterobacterhom,Legionella pneumophila, Morganella morganii, Providenciahom, Pseudomonashom, Serratiahom, Stenotrophomonas maltophilia,
lwm yam:Chlamydia trachomatis,Chlamydophila mob ntsws, Chlamydophila psittaci, Coxiella burnetti, Mycoplasma pneumoniae.
*Lub cev rhiab heev nyob rau hauv qhov tsis muaj kis tau ua hauj
1 Tsis suav hom Kab mob ntsws dej liabpenicillin tiv taus
Tsuas tshuaj thiab tswj hwm
Lub txim rau kev tswj hwm ntawm qhov ncauj yog npaj rau siv hauv kev kho mob hauv hlwb.
Qhov rhiab siab rau Augmentin® yuav txawv raws qhov chaw thiab lub sijhawm. Ua ntej sau tshuaj, yog tias ua tau nws yuav tsum tau los ntsuas qhov rhiab ntawm cov kab mob raws li cov ntaub ntawv hauv zos thiab txiav txim siab qhov rhiab siab los ntawm kev kuaj thiab ntsuas cov qauv los ntawm tus neeg mob tshwj xeeb, tshwj xeeb yog kis mob hnyav.
Cov tshuaj muab rau noj yog teem raws li lub hnub nyoog, lub cev nyhav, lub raum kev ua haujlwm, kev kis tus kab mob, nrog rau qhov mob hnyav heev.
Augmentin® pom zoo kom noj thaum pib noj mov. Lub sijhawm kho yog nyob ntawm tus neeg mob cov lus teb rau kev kho mob. Qee cov kab mob pathologies (tshwj xeeb, osteomyelitis) yuav xav tau kev kawm ntev dua. Txoj kev kho yuav tsum tsis txhob txuas ntxiv rau 14 hnub yam tsis rov ntsuas nws tus mob. Yog tias tsim nyog, nws yog qhov ua tau los ua cov kauj ruam kev kho mob (thawj zaug, kev tswj hwm cov tshuaj nrog kev hloov pauv tom qab kev tswj hwm hauv qhov ncauj).
Cov menyuam yaus txij li 2 hlis txog 12 xyoos lossis hnyav dua 40 kg
Qhov koob tshuaj, nyob ntawm lub hnub nyoog thiab qhov hnyav, tau qhia hauv mg / kg lub cev qhov hnyav hauv ib hnub lossis hauv milliliters ntawm cov kev ncua kev ua tiav.
Cov tshuaj pom zoo:
- txij li 25 mg / 3.6 mg / kg / hnub mus txog 45 mg / 6.4 mg / kg / hnub, muab faib ua 2 koob tshuaj, txhawm rau kis mob me thiab mob nyhav (mob tons, ua mob rau daim tawv thiab cov nqaij mos mos)
- txij li 45 mg / 6.4 mg / kg / hnub txog 70 mg / 10 mg / kg / hnub, muab faib ua 2 koob tshuaj, txhawm rau kho kab mob loj dua (mob otitis media, sinusitis, mob ntsws qis dua).
Lub yim hli ntuj xaiv ib koob tshuaj xaiv raws qhov hnyav lub cev
Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawv
Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug.
Kwv yees li 60 ml ntawm cov dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, cia lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 92 ml ntawm dej yog xav tau los npaj qhov kev ncua.
Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.
Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm kev ncua ntawm kev siv tshuaj Augmentin tuaj yeem raug txhaws ib nrab nrog dej.
3D duab
| Hmoov rau kev tshem tawm ntawm qhov ncauj | 5 ml |
| yam tshuaj: | |
| amoxicillin trihydrate (hauv amoxicillin) | 125 mg |
| 200 mg | |
| 400 mg | |
| poov tshuaj clavulanate (hauv cov ntsiab lus ntawm clavulanic acid) 1 | 31,25 mg |
| 28,5 mg | |
| 57 mg | |
| tus zam: xanthan ntawm cov pos hniav - 12.5 / 12.5 / 12.5 mg, aspartame - 12.5 / 12.5 / 12.5 mg, succinic acid - 0.84 / 0.84 / 0.84 mg, colloidal silicon dioxide - 25/25/25 mg, hypromellose - 150 / 79.65 / 79.65 mg, txiv kab ntxwv tsw 1 - 15/15/15 mg, txiv kab ntxwv tsw 2 - 11.25 / 11.25 / 11.25 mg, tsw raspberry - 22.5 / 22.5 / 22.5 mg, cov tshuaj tsw qab "Lub suab tawm suab" - 23.75 / 23.75 / 23.75 mg, silicon dioxide - 125 / txog 552 / txog li 900 mg |
1 Hauv kev tsim cov tshuaj, poov tshuaj clavulanate raug nteg nrog 5% ntau dhau.
| Zaj duab xis-coated ntsiav tshuaj | 1 tab. |
| yam tshuaj: | |
| amoxicillin trihydrate (hauv amoxicillin) | 250 mg |
| 500 mg | |
| 875 mg | |
| poov tshuaj clavulanate (hais txog clavulanic acid) | 125 mg |
| 125 mg | |
| 125 mg | |
| tus zam: magnesium stearate - 6.5 / 7.27 / 14.5 mg, sodium carboxymethyl hmoov txhuv nplej siab - 13/21/29 mg, colloidal silicon dioxide - 6.5 / 10.5 / 10 mg, MCC - 650 / txog 1050/396, 5 mg | |
| zaj duab xis sheath: titanium dioxide - 9.63 / 11.6 / 13.76 mg, hypromellose (5 cps) - 7.39 / 8.91 / 10.56 mg, hypromellose (15 cps) - 2.46 / 2.97 / 3.52 mg, macrogol 4000 - 1.46 / 1.76 / 2.08 mg, macrogol 6000 - 1.46 / 1.76 / 2.08 mg, dimethicone 500 ( kua roj silicone) - 0.013 / 0.013 / 0.013 mg, dej huv 1 - - / - / - |
1 Cov dej lim tawm hauv cov txheej txheej zaj duab xis.
Siv thaum cev xeeb tub
Augmentin tuaj yeem siv tau los ntawm cov poj niam lub sijhawm thaum coj tus menyuam hauv rooj plaub thaum cov txiaj ntsig xav tau rau leej niam outweigh qhov kev pheej hmoo rau tus menyuam hauv plab.
Augmentin tuaj yeem raug siv thaum pub mis. Nyob rau hauv kev tshwm sim uas kev noj cov tshuaj pab txhawb kev txhim kho cov kev mob tsis zoo nyob rau hauv tus menyuam, qhov teeb meem ntawm kev txwv tsis pub mis niam yuav tsum xav txog.
Kev phiv tshuaj
Augmentin tuaj yeem pab txhawb kev txhim kho ntawm cov kev xav tsis zoo no:
- Candidiasis ntawm mucous daim nyias nyias thiab tawv nqaij.
- Raws plab, xeev siab thiab ntuav.
- Mob taub hau, kiv taub hau.
- Cov tawv nqaij khaus, urticaria, tawm pob.
Nrog kev txhim kho kev ua xua, kev hloov kho Augmentin yog tso tseg tam sim ntawd.
Nws yog ib qho tsim nyog yuav tsum qhia rau tus kws kho mob txog kev txhim kho cov kev mob tshwm sim txhawm rau txhawm rau kho qhov ntau npaum li cas lossis xaiv cov kev kho mob kom zoo.
Noj ntau dhau
Yog tias muaj qhov sib txuam ntau dhau, kev txhim kho ntawm qhov tsis xav tau sab los ntawm txoj hnyuv thiab cov teeb meem hauv cov dej-electrolyte sib npaug yog qhov ua tau. Qhov tshwm sim ntawm kev tsim hnoos hauv cov neeg mob uas lub cev tsis zoo ua haujlwm ntawm lub raum thiab hauv cov neeg uas tau txais tshuaj ntau dua.
Yog tias noj ntau dhau, koj yuav tsum tau sab laj nrog kws kho mob sai sai txog kev teem sijhawm kho cov tsos mob uas tsom mus rau txoj haujlwm ua haujlwm ntawm lub plab thiab ua kom rov qab cov dej-electrolyte tshuav nyiaj li cas. Cov khoom siv ua ke ntawm Augmentin raug tawm dhau los ntawm cov txheej txheem hemodialysis.
Yeeb tshuaj sib cuam tshuam
Kev siv ua ke ib txhij ntawm cov tshuaj Augmentin thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, kev siv cov tshuaj Augmentin thiab probenecid tib lub sijhawm tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid.
Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol. Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li kev siv Augmentin thiab methotrexate ntau tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate.
Zoo li lwm yam tshuaj tua kab mob, tshuaj Augmentin tuaj yeem cuam tshuam cov hnyuv microflora, ua rau txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua tau zoo ntawm kev sib xyaw ua ke ntawm qhov ncauj.
Cov lus pom zoo ntxiv
Ua ntej pib siv cov Augmentin, keeb kwm kev kho mob ntawm tus neeg mob yuav tsum txheeb xyuas qhov tshwm sim kev tiv thaiv tus kab mob siab rau penicillin, cephalosporin thiab lwm yam.
Augmentin Kev raug ncua yuav nyob nrog tus neeg mob cov hniav. Txhawm rau kom tsis txhob muaj kev txhim kho ntawm cov txiaj ntsig zoo li no, nws txaus los ua raws txoj cai ntawm kev tu lub qhov ncauj - txhuam koj cov hniav, siv yaug dej.
Kev nkag rau Augmentin yuav ua rau kiv taub hau, yog li rau lub sijhawm ntawm kev kho mob yuav tsum tsis txhob tsav tsheb thiab ua haujlwm uas yuav tsum muaj kev mloog ntxiv.
Yuav siv tsis tau Augmentin yog tias xav tias tsam muaj mob mononucleosis uas xav tias muaj.
Augmentin muaj kev thev taus zoo thiab muaj tshuaj lom tsawg. Yog hais tias siv lub sijhawm ntev ntawm cov tshuaj yog qhov yuav tsum tau, ces nws yog qhov yuav tsum tau ua ntu zus los kuaj xyuas kev ua haujlwm ntawm lub raum thiab mob siab.
Kev piav qhia ntawm daim ntawv tshuaj
Hmoov: dawb lossis yuav luag dawb, nrog tus yam ntxwv tsw. Thaum diluted, ib qho kev ncua ntawm dawb lossis yuav luag dawb yog tsim. Thaum sawv ntsug, ib qho dej dawb lossis dawb yuav luag nag lossis daus maj mam ua kom qeeb.
Ntsiav tshuaj, 250 mg + 125 mg: them nrog zaj duab xis membrane los ntawm dawb mus rau yuav luag dawb, kheej li lub qw hauv cov duab, nrog cov ntawv sau "AUGMENTIN" ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.
Ntsiav tshuaj, 500 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb hauv cov xim, oval, nrog cov ntawv sau extruded "AC" thiab txoj kev pheej hmoo ntawm ib sab.
Ntsiav tshuaj, 875 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb, kheej li lub qw, nrog cov tsiaj ntawv "A" thiab "C" ntawm ob sab thiab ib txoj kab txhaum ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.
Cov Tshuaj Hauv Tshuaj
Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.
Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid beta-lactamases, uas feem ntau lub luag haujlwm tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv cov chromosomal beta-lactamases ntawm hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.
Muaj cov clavulanic acid nyob hauv Augmentin ® kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.
Hauv qab no yog cov haujlwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid hauv vitro .
Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid
Gram-zoo aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia astero> suav nrog Tus kab mob Streptococcus pyogenes 1.2, Streptococcus agalactiae 1.2 (lwm beta hemolytic streptococci) 1,2, Dab Tsi Staphylococcus aureus (rhiab rau methicillin) 1, Dab Tsi Staphylococcus saprophyticus (rhiab rau methicillin), coagulase-negative staphylococci (rhiab rau methicillin).
Gram-zoo anaerobes: Clostr> suav nrog Peptostreptococcus magnus, Peptostreptococcus micros.
Gram-negative aerobes: Tus mob Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.
Gram-negative anaerobes: Bactero> suav nrog Bactero> suav nrog Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.
Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.
Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim
Gram-negative aerobes: Escherichia coli 1, Klebsiella spp., suav nrog Klebsiella oxytoca, Klebsiella pneumoniae 1, Proteus spp., suav nrog Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.
Gram-zoo aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus mob ntsws 1,2 pab pawg neeg streptococcus Viridans.
Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid
Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.
Lwm yam: Chlamydia spp., suav nrog Chlamydia mob ntsws, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.
1 Rau cov kab mob no, kev kho mob ua tau zoo ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid tau ua kom pom hauv kev tshawb fawb soj ntsuam.
2 Hom kab ntawm cov kab mob no tsis tsim cov tshuaj beta-lactamase. Kev nkag siab nrog amoxicillin monotherapy qhia zoo ib yam li kev nkag siab zoo rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.
Cov Tshuaj Pharmacokinetics
Ob lub cev sib xyaw ntawm Augmentin ® kev npaj - amoxicillin thiab clavulanic acid - tau sai thiab tag nrho los ntawm txoj hnyuv plab tom qab kev tswj hwm qhov ncauj. Qhov nqus ntawm cov khoom xyaw nquag ntawm cov tshuaj Augmentin ® yog qhov zoo dua rau thaum muaj kev noj tshuaj thaum pib noj mov.
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob siv 40 mg + 10 mg / kg / hnub ntawm Augmentin ® hauv peb koob tshuaj, hmoov rau lub qhov ncauj ncua, 125 mg + 31.25 mg hauv 5 ml (156.25 mg).
Yooj yim pharmacokinetic
| Tshuaj | Koob tshuaj mg / kg | Cmax mg / l | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| 40 | 7,3±1,7 | 2,1 (1,2–3) | 18,6±2,6 | 1±0,33 | |
| 10 | 2,7±1,6 | 1,6 (1–2) | 5,5±3,1 | 1,6 (1–2) |
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2–12 xyoo rau ntawm lub plab khoob tau Augmentin ®, hmoov rau lub qhov ncauj ncua, 200 mg + 28.5 mg hauv 5 ml (228 , 5 mg) ntawm ib koob ntawm 45 mg + 6.4 mg / kg / hnub, muab faib ua ob zaug.
Yooj yim pharmacokinetic
| Yam khoom muaj sia | Cmax mg / l | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| Amoxicillin | 11,99±3,28 | 1 (1–2) | 35,2±5 | 1,22±0,28 |
| Clavulanic acid | 5,49±2,71 | 1 (1–2) | 13,26±5,88 | 0,99±0,14 |
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau txais hauv kev tshawb fawb sib txawv yog qhia hauv qab no thaum cov neeg tuaj yeem noj qab haus huv tau noj ib zaug ntawm Augmentin ®, hmoov rau kev tshem tawm qhov ncauj, 400 mg + 57 mg hauv 5 ml (457 mg).
Yooj yim pharmacokinetic
| Yam khoom muaj sia | Cmax mg / l | Tmax xyob h | AUC, mg · h / l |
| Amoxicillin | 6,94±1,24 | 1,13 (0,75–1,75) | 17,29±2,28 |
| Clavulanic acid | 1,1±0,42 | 1 (0,5–1,25) | 2,34±0,94 |
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb sib txawv, thaum cov neeg tuaj yeem yoo mov sai:
- 1 tab. Augmentin ®, 250 mg + 125 mg (375 mg),
- 2 ntsiav tshuaj Augmentin ®, 250 mg + 125 mg (375 mg),
- 1 tab. Augmentin ®, 500 mg + 125 mg (625 mg),
- 500 mg ntawm amoxicillin,
- 125 mg ntawm clavulanic acid.
Yooj yim pharmacokinetic
| Tshuaj | Koob tshuaj mg | Cmax mg / ml | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| Augmentin ®, 250 mg + 125 mg | 250 | 3,7 | 1,1 | 10,9 | 1 |
| Augmentin ®, 250 mg + 125 mg, 2 ntsiav tshuaj | 500 | 5,8 | 1,5 | 20,9 | 1,3 |
| Augmentin ®, 500 mg + 125 mg | 500 | 6,5 | 1,5 | 23,2 | 1,3 |
| Amoxicillin 500 mg | 500 | 6,5 | 1,3 | 19,5 | 1,1 |
| Augmentin ®, 250 mg + 125 mg | 125 | 2,2 | 1,2 | 6,2 | 1,2 |
| Augmentin ®, 250 mg + 125 mg, 2 ntsiav tshuaj | 250 | 4,1 | 1,3 | 11,8 | 1 |
| Clavulanic acid, 125 mg | 125 | 3,4 | 0,9 | 7,8 | 0,7 |
| Augmentin ®, 500 mg + 125 mg | 125 | 2,8 | 1,3 | 7,3 | 0,8 |
Thaum siv cov tshuaj Augmentin ®, ntshav ntau ntawm amoxicillin zoo ib yam li cov tshuaj noj ntawm qhov ncauj ntawm amoxicillin koob tshuaj sib npaug.
Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb cais, thaum muaj kev noj qab haus huv sai sai cov neeg ua haujlwm nqa:
- 2 ntsiav tshuaj Augmentin ®, 875 mg + 125 mg (1000 mg).
Yooj yim pharmacokinetic
| Tshuaj | Koob tshuaj mg | Cmax mg / l | Tmax xyob h | AUC, mg · h / l | T1/2 xyob h |
| 1750 | 11,64±2,78 | 1,5 (1–2,5) | 53,52±12,31 | 1,19±0,21 | |
| 250 | 2,18±0,99 | 1,25 (1–2) | 10,16±3,04 | 0,96±0,12 |
Ib yam li iv kev tswj hwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid muaj nyob hauv ntau cov ntaub so ntswg thiab cov kua dej interstitial (gall zais zis, lub plab hauv plab, tawv nqaij, rog thiab cov leeg nqaij, synovial thiab peritoneal kua, kua tsib, kua paug) )
Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tau tias kwv yees li 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin hauv ntshav plasma khi rau cov ntshav plasma protein.
Hauv kev tshawb nrhiav tsiaj, tsis muaj kev txuam ntawm lub Cheebtsam ntawm Augmentin ® kev npaj hauv ib qho khoom hauv lub cev.
Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Cov kab ntawm clavulanic acid kuj tseem yuav pom nyob hauv niam cov kua mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab thiab ua paug rau ntawm lub qhov ncauj mob ntawm lub qhov ncauj, tsis muaj lwm yam tsis zoo ntawm amoxicillin thiab clavulanic acid rau kev noj qab haus huv ntawm cov niam mis-pub mis paub.
Cov kev tshawb fawb tsiaj yug me nyuam tau pom tias amoxicillin thiab clavulanic acid hla qhov chaw teeb meem. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.
10-25% ntawm thawj zaug koob tshuaj amoxicillin raug ntiab tawm los ntawm ob lub raum ua lub zog tsis haum rau lub cev (cov tshuaj penicilloic acid). Clavulanic acid tau dav dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid thiab amino-4-hydroxy-butan-2-ib thiab tau tawm ntawm cov raum Lub plab zom zaws, nrog rau cov huab cua uas tsis tas sijhawm nyob hauv daim ntawv cov roj carbon dioxide.
Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab.
Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid raug tso tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab noj 1 lub rooj. 250 mg + 125 mg lossis 1 ntsiav tshuaj 500 mg + 125 mg.
Kev tswj hwm tib lub sij hawm ntawm probenecid qeeb ua rau qhov kev zam ntawm amoxicillin, tab sis tsis yog clavulanic acid (saib "Kev Sib Hloov").
Kev Taw Qhia Augmentin ®
Kev sib xyaw ntawm amoxicillin nrog clavulanic acid yog qhia rau kev kho mob ntawm cov kab mob ntawm cov chaw hauv qab no tshwm sim los ntawm cov kab mob me me nkag siab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid:
cov mob ua pa sab sauv (suav nrog rau tus mob ENT), xws li ua mob tonsillitis, mob ntsws, mob otitis, feem ntau tshwm sim Tus kab mob Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 thiab Streptococcus pyogenes, (tshwj tsis yog Augmentin ntsiav tshuaj 250 mg / 125 mg),
cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, mob ntsws mob ntsws, thiab mob ntsws, feem ntau tshwm sim Kab mob ntsws Streptococcus mob ntsws, Haemophilus khaub thuas 1 thiab Moraxella catarrhalis 1,
mob txeeb zig, xws li mob cystitis, tus mob urethritis, pyelonephritis, kis mob rau poj niam lub cev ua paug, feem ntau tshwm sim los ntawm hom tsiaj hauv tsev neeg Enterobacteriaceae 1 (feem ntau yog Escherichia coli 1 ), Dab Tsi Staphylococcus saprophyticus thiab hom Enterococcusli zoo li kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae 1,
daim tawv nqaij thiab cov nqaij mos muag kis mob feem ntau tshwm sim Staphylococcus aureus 1, Tus kab mob Streptococcus pyogenes thiab hom Bacteroides 1,
kis mob ntawm cov pob txha thiab pob qij txha, xws li osteomyelitis, feem ntau tshwm sim Staphylococcus aureus 1, yog tias tsim nyog, kho lub sijhawm ntev ntev yog qhov ua tau.
cov kab mob odontogenic, piv txwv li kab mob txha caj qaum, odontogenic maxillary sinusitis, mob hniav ntau heev nrog kev kis mob cellulitis (tsuas yog rau cov ntsiav tshuaj Augmentin cov ntawv, ntau npaum li 500 mg / 125 mg, 875 mg / 125 mg),
lwm cov kab mob sib xyaw (piv txwv, septic rho menyuam, tom qab sepsis, mob intraabdominal sepsis) yog ib feem ntawm kev kho mob kauj ruam (tsuas yog rau cov ntsiav tshuaj Augmentin ntau npaum 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),
1 Cov neeg sawv cev ntawm cov kab mob tsis txawv txav tsim cov beta-lactamase, uas ua rau lawv tsis raug tshuaj amoxicillin (saib. Pharmacodynamics).
Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag. Augmentin ® tseem qhia tau rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me uas tsim cov beta-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.
Qhov rhiab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av thiab dhau sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov chaw. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.
Cov Yuav Tsum Muaj
Rau txhua daim ntawv qhia
cov tshuaj tiv thaiv tsis haum rau amoxicillin, clavulanic acid, lwm yam tshuaj, tshuaj tua kab mob beta-lactam (piv txwv li penicillins, cephalosporins) hauv anamnesis,
yav dhau los lub sijhawm daj ntseg lossis lub siab ua kom lub siab ua haujlwm thaum siv amoxicillin nrog clavulanic acid nyob hauv keeb kwm.
Ib qho ntxiv, rau hmoov rau kev tshem tawm qhov ncauj, 125 mg + 31.25 mg
Ib qho ntxiv, rau hmoov rau kev tshem tawm qhov ncauj, 200 mg + 28.5 mg, 400 mg + 57 mg
lub raum khiav tsis zoo (Cl creatinine tsawg dua 30 ml / min),
cov menyuam yaus hnub nyoog txog li 3 hlis.
Ntxiv rau qhov ntxig zaj duab xis ntsiav tshuaj, 250 mg + 125 mg, 500 mg + 125 mg
cov menyuam tsis tau muaj 12 xyoos lossis lub cev hnyav dua 40 kg.
Tsis tas li ntawd, rau cov ntsiav tshuaj-txheej roj, 875 mg + 125 mg
lub raum khiav tsis zoo (Cl creatinine tsawg dua 30 ml / min),
cov menyuam tsis tau muaj 12 xyoos lossis lub cev hnyav dua 40 kg.
Nrog saib xyuas: ua rau lub siab ua haujlwm tsis zoo.
Cev xeeb tub thiab lactation
Hauv kev tshawb fawb ntawm kev ua tiav tsiaj hauv tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin ® tsis ua rau muaj teebmeem teratogenic.
Hauv txoj kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev puas ua ntej, nws tau pom tias kev kho nrog prophylactic nrog Augmentin be tej zaum cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos. Zoo li txhua yam tshuaj, Augmentin ® tshuaj tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias cov kev cia siab pab rau leej niam muaj txiaj ntsig zoo ua rau muaj kev pheej hmoo rau menyuam hauv plab.
Cov tshuaj Augmentin ® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab lossis ua paug rau ntawm cov kua qog ua rau lub qhov ncauj ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov tshuaj yeeb dej caw ntawm cov tshuaj no mus rau niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos niam mis. Yog tias muaj qhov tshwm sim tsis zoo hauv cov menyuam mos uas tseem noj niam mis, nws yuav tsum tau tsum tsis txhob pub niam mis.
Sab sij huam
Cov xwm txheej tsis zoo uas tau nthuav tawm hauv qab no yog teev raws li kev puas tsuaj rau cov kabmob thiab cov nruab nrog cev thiab qhov ntau zaus tshwm sim. Qhov ntau zaus ntawm kev tshwm sim tau txiav txim siab raws li hauv qab no: ntau heev - /1 / 10, feem ntau ≥1 / 100 thiab PV, ntshav liab, eosinophilia, thrombocytosis.
Los ntawm lub nruab zog: tsis tshua muaj tshwm sim - angioedema, kev phiv tshuaj anaphylactic, tus mob zoo ib yam li kev mob ntshav dej, tshuaj tsis haum vasculitis.
Los ntawm lub paj hlwb: tso tsis tau - kiv taub hau, mob taub hau, tsis tshua muaj tshwm sim - thim rov qab hyperactivity, convulsions (txiav tau tuaj yeem tshwm sim rau cov neeg mob uas lub raum tsis ua haujlwm, zoo li hauv cov neeg uas tau txais cov tshuaj ntau heev), insomnia, ntxhov siab, ntxhov siab, hloov tus cwj pwm.
- cov neeg laus: ntau heev - raws plab, nquag - xeev siab, ntuav,
- menyuam yaus: feem ntau - raws plab, xeev siab, ntuav,
- tag nrho cov pejxeem: xeev siab yog feem ntau cuam tshuam nrog kev siv cov tshuaj ntau ntawm cov tshuaj. Yog tias tom qab pib noj cov tshuaj muaj qhov tsis txaus siab los ntawm lub plab hnyuv, tuaj yeem tshem tawm yog tias Augmentin ® noj thaum pib noj mov, tsis tshua zoo rau kev zom, tsis tshua muaj kab mob tua kab mob (nrog rau pseudomembranous colitis thiab hemorrhagic colitis), cov plaub hau dub »Tus nplaig, mob plab, mob plab, tshem tawm ntawm txheej txheej hniav txheej hniav txha hniav laus hauv menyuam yaus. Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob ua kom pom cov hniav, txij li txhuam koj cov hniav tau txaus.
Nyob rau ib feem ntawm daim siab thiab kais plab: tsis cuag li - ib qho kev nce ntawm ib qho txiaj ntsig ntawm AST thiab / lossis ALT. Qhov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob beta-lactam, tab sis nws qhov tseem ceeb hauv cov chaw kho mob tsis paub. Tsis tshua muaj - kab mob siab thiab mob cholestatic daj ntseg. Cov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob nrog penicillin tshuaj tua kab mob thiab cephalosporins. Kev nce siab ntawm bilirubin thiab alkaline phosphatase.
Cov kev mob tshwm sim los ntawm daim siab yog pom feem ntau hauv cov txiv neej thiab cov neeg laus laus thiab yuav cuam tshuam nrog kev kho mob mus ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus.
Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, tab sis qee qhov xwm txheej lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg mob uas mob nyhav los yog cov neeg mob tau txais cov tshuaj hepatotoxic.
Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: tsis ncaw - pob khaus, khaus, urticaria, tsis tshua muaj erythema multiforme, tsis tshua muaj Stevens-Johnson syndrome, mob ua paug rau daim tawv nqaij, ua rau mob ua paug, ua rau mob ua paug, ua paug rau tus mob txha nqaj qaum.
Yog tias muaj tawv nqaij tsis haum, kho nrog Augmentin ® yuav tsum tsis ua mus ntxiv.
Los ntawm ob lub raum thiab mob txeeb zig: muaj tsawg kawg - interstitial nephritis, crystalluria (saib "Overdose"), hematuria.
Kev sib txuam
Kev siv ua ke ib txhij ntawm cov tshuaj Augmentin ® thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin ® thiab probenecide tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid.
Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol.
Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li kev siv Augmentin thiab methotrexate ntau tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate.
Zoo li lwm yam tshuaj tua kab mob, Augmentin ® kev npaj yuav cuam tshuam rau lub plab hnyuv microflora, ua rau kev txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua haujlwm ntawm kev sib xyaw ua ke ntawm qhov ncauj.
Cov ntawv nyeem piav qhia feem ntau tsis tshua muaj neeg nce MHO hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias tsim nyog, txoj kev tswj hwm ntawm Augmentin ® npaj nrog PV anticoagulants lossis MHO yuav tsum tau ua tib zoo saib xyuas thaum sau tshuaj lossis thim kev Augmentin ® kev npaj kho kom haum rau cov tshuaj anticoagulants rau kev tswj hwm qhov ncauj.
Cov lus qhia tshwj xeeb
Ua ntej pib kho nrog Augmentin ®, nws yog ib qho tsim nyog yuav tsum sau ib qho keeb kwm kev kho mob kom zoo txog kev tiv thaiv kab mob yav dhau los rau kev siv penicillins, cephalosporins lossis lwm yam tshuaj uas ua rau muaj kev tsis haum tshuaj ntawm tus neeg mob.
Cov kev mob hnyav thiab qee zaum kuj ua rau lub cev tsis haum tus mob (anaphylactic tshua) rau penicillins tau piav qhia. Txoj kev pheej hmoo ntawm cov kev tawm tsam zoo li no yog qhov siab tshaj plaws rau cov neeg mob uas muaj keeb kwm ntawm kev tsis haum lub cev rau penicillins. Yog tias muaj qhov ua xua, nws yuav tsum tsum tsis kho nrog Augmentin ® thiab pib kho lwm txoj kev kho kom haum.
Thaum muaj kev phiv tshuaj nyhav, epinephrine yuav tsum muab rau tus neeg mob tam sim ntawd. Kev kho cov pa oxygen, kev tswj hwm kev tswj hwm ntawm GCS thiab kev pabcuam hauv airway patency, suav nrog kev nkag mus ntxiv, kuj tseem yuav tsum ua.
Yog hais tias muaj kev txhawj xeeb ntawm kev kis mob mononucleosis, Augmentin ® yuav tsum tsis txhob siv, vim hais tias nyob rau hauv cov neeg mob tus mob no, amoxicillin tuaj yeem ua rau mob pob khaus zoo li tawv nqaij ua pob, uas ua rau muaj kev cuam tshuam rau kev kuaj mob.
Kev kho mob mus ntev nrog Augmentin ® tuaj yeem ua rau muaj kev tawm tsam ntau ntawm cov kab mob tsis haum.
Feem ntau, Augmentin ® tau zam zoo thiab muaj cov yam ntxwv toxicity tsis zoo ntawm txhua tus penicillins. Thaum kho kho nrog Augmentin long lub sijhawm ntev, nws raug nquahu kom ntsuas qee lub sijhawm ua haujlwm ntawm lub raum, mob siab thiab ntshav.
Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj thaum noj mov.
Hauv cov neeg mob uas tau txais kev sib xyaw ntawm amoxicillin nrog clavulanic acid ua ke nrog indirect (qhov ncauj) anticoagulants, nyob rau hauv cov xwm txheej tsis tshua muaj, qhov nce hauv PV (nce hauv MHO) tau tshaj tawm. Nrog rau kev sib koom tes ntawm kev tiv thaiv kabmob (qhov ncauj) anticoagulants nrog kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev saib xyuas ntawm cov ntsuas tseem ceeb yog qhov tsim nyog. Yuav kom tswj tau qhov xav tau ntawm qhov ncauj ua kom lub ntsej muag, qhov ntau npaum yuav tsum tau hloov kho.
Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov tshuaj ntawm Augmentin ® yuav tsum tau kho raws li kev ua txhaum cai (saib "Dosage thiab administration", Cov neeg mob uas lub raum tsis ua hauj lwm zoo).
Hauv cov neeg mob nrog txo diuresis, crystalluria tsis tshua muaj tshwm sim, feem ntau nrog kev kho mob kho mob. Thaum lub sijhawm tswj hwm ntawm amoxicillin koob tshuaj ntau, nws raug nquahu kom noj cov kua txaus thiab tswj cov diuresis kom txaus los txo qhov muaj feem ntawm kev tsim cov tshuaj amoxicillin muaju (saib "Overdose").
Noj cov tshuaj Augmentin ® sab hauv ua rau cov ntsiab lus ntawm amoxicillin nyob rau hauv cov zis, uas tuaj yeem ua rau cov kev ntsuas tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis (piv txwv, Benedict test, Feling test). Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis.
Kev tu xyuas hniav yuav pab tiv thaiv kom hniav tsis txhob cuam tshuam nrog kev siv tshuaj, vim nws txaus los txhuam koj cov hniav (rau kev ncua).
Nws yog ib qho tsim nyog yuav tau siv cov tshuaj Augmentin ® tsis pub dhau 30 hnub txij li lub sijhawm qhib lub pob ntawm laminated txhuas ntawv ci (rau cov ntsiav tshuaj)
Kev quav yeeb quav tshuaj thiab quav yeeb tshuaj. Tsis pom muaj kev quav yeeb tshuaj, quav tshuaj thiab kev tsis haum tshuaj cuam tshuam nrog kev siv tshuaj Augmentin ® tau pom.
Cuam Tshuam rau kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog tshuab. Txij li thaum cov tshuaj yuav ua rau kiv taub hau, nws yog ib qho tsim nyog ceeb toom rau cov neeg mob txog kev ceev faj thaum tsav tsheb lossis ua haujlwm nrog cov tshuab txav.
Daim ntawv tso tawm
Hmoov rau kev tshem tawm ntawm qhov ncauj, 125 mg + 31.25 mg hauv 5 ml. Hauv lub raj mis ntawm cov ntshiab iav, kaw los ntawm lub hau ntswj-ntawm aluminium cap nrog kev tswj ntawm thawj qhib, 11,5 g .1 fl. ua ke nrog nrog ntsuas lub hau hauv kab ntawv tuab.
Hmoov rau kev tshem tawm ntawm qhov ncauj, 200 mg + 28.5 mg hauv 5 ml, 400 mg + 57 mg hauv 5 ml. Hauv lub khob iav pob tshab kaw nrog lub hau ntswj-ntawm txhuas lub taub hau nrog kev qhib thawj tswj, 7.7 g (rau qhov ntau npaum li 200 mg + 28.5 mg hauv 5 ml) lossis 12.6 g (rau qhov ntau npaum li 400 mg + 57 mg hauv 5 ml ) 1 fl. ua ke nrog ntsuas lub ntsuas los yog lub koob txhaj tshuaj hauv lub thawv ntawv thawv.
Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg. Hauv aluminium / PVC blister 10 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntawv ci ntawv nyiaj ntim khoom hauv thawv ntawv thawv.
Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg. Hauv aluminium / PVC / PVDC blister 7 lossis 10 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntim ntawm cov ntawv ci laminated txhuas hauv thawv ntawv thawv.
Cov ntsiav tshuaj ua yeeb yaj kiab, 850 mg + 125 mg. Hauv aluminium / PVC blister 7 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntawv ci ntawv nyiaj ntim khoom hauv thawv ntawv thawv.
Chaw tsim tshuaj paus
SmithKlein Puam P.C. BN14 8QH, West Sussex, Vorsin, Clarendon Road, UK.
Lub npe thiab chaw nyob ntawm cov chaw muaj cai uas muaj npe rau daim ntawv pov thawj rau npe tau muab: CJSC GlaxoSmithKline Trading. 119180, Moscow, Yakimanskaya nab., 2.
Xav paub ntau ntxiv, sib cuag: GlaxoSmithKline Trading CJSC. 121614, Moscow, st. Krylatskaya, 17, bldg. 3, pem teb 5. Kev Lag Luam Chaw Ua Si "Roob Krylatsky."
Xovtooj: (495) 777-89-00, fev: (495) 777-89-04.
Augmentin ® hnub tas sijhawm
zaj duab xis-ntsiav tshuaj 250 mg + 125 mg 250 mg + 125 - 2 xyoos.
zaj duab xis-coated ntsiav tshuaj 500 mg + 125 mg - 3 xyoos.
zaj duab xis-ntsiav tshuaj 875 mg + 125 mg - 3 xyoos.
hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj 125mg + 31.25mg / 5ml - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.
hmoov rau kev ncua rau kev tswj hwm qhov ncauj 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.
hmoov rau kev ncua rau kev tswj hwm qhov ncauj 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.
Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.
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Repaglinide: cov tshuaj xav kom ntshav qab zib
Repaglinide: kev cia siab ntawm cov tshuaj hauv cov ntshav qab zib mellitus Qee zaum tshwj xeeb kev noj zaub mov zoo thiab kev ua kom lub cev tsis tuaj yeem muab cov ntshav qabzib hauv cov ntshav qab zib uas muaj 2 hom mob. ... -
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