Dab tsi yog qhov txawv ntawm Finlepsin thiab Finlepsin Retard? Finlepsin retard: cov lus qhia rau kev siv

Tsoomfwv Chaw rau Neurosurgery

TSIM NYOG TSHIAB.

Tab sis koj yog tus siv tsis tau tso cai.

Yog tias koj tau sau npe ua ntej lawm, tom qab ntawd "nkag mus" (daim ntawv nkag rau hauv ntu sab xis ntawm qhov chaw). Yog tias qhov no yog koj thawj zaug ntawm no, zwm npe.

Yog tias koj sau npe, koj yuav muaj peev xwm taug qab cov lus teb rau koj cov lus hauv yav tom ntej, txuas ntxiv kev sib tham hauv cov ncauj lus nrog lwm tus neeg siv thiab cov neeg pab tswv yim. Tsis tas li ntawd, kev sau npe yuav tso cai rau koj los ua tus sau ntawv ntiag tug nrog cov kws pab tswv yim thiab lwm tus neeg siv ntawm lub xaib.

Tsuas tshuaj thiab tswj hwm

100 mg nyob rau yav tsaus ntuj 100 mg nyob rau yav tsaus ntuj
Ib koob tshuaj txij nkawm ntawm 200-600 mg txhua hnub thaum sawv ntxov 400-600 mg thaum yav tsaus ntuj
200 mg thaum sawv ntxov 200-400 mg nyob rau yav tsaus ntuj 200-400 mg thaum sawv ntxov 400-600 mg thaum yav tsaus ntuj

Cov koob tshuaj uas tau qhia hauv lub rooj yuav tsum tsis pub tshaj.
Kev kho mob ntawm kev haus cawv haus cawv hauv tsev kho mob.
Qhov nruab nrab txhua hnub koob sib raug rau 600 mg ntawm carbamazepine (200 mg thaum sawv ntxov thiab 400 mg thaum yav tsaus ntuj).
Oh
Hauv cov xwm txheej loj, hauv thawj hnub, qhov tshuaj yuav muab ntau ntxiv rau 1200 mg ntawm carbamazepine ib hnub, uas tau muab faib ua 2 koob tshuaj. Finlepsin retard yuav tsum tsis txhob txuam nrog cov tshuaj sedative-hypnotic. Yog tias tsim nyog, Finlepsin retard tuaj yeem ua ke nrog lwm cov tshuaj uas siv los kho cawv cawv. Thaum kho, nws yog ib qho tsim nyog yuav tsum soj ntsuam cov ntsiab lus ntawm cov carbamazepine hauv cov ntshav ntshav. Hauv kev sib txuas nrog kev txhim kho kev mob tshwm sim los ntawm lub hauv nruab nrab thiab lub zog ntawm lub paj hlwb, cov neeg mob tau ua tib zoo saib nyob hauv tsev kho mob.
Trigeminal neuralgia, idiopathic neuropathy ntawm lub paj hlwb glossopharyngeal.
Qhov pib txhaj tshuaj yog 200-400 mg ntawm carbamazepine ib hnub, uas tau muab faib ua 2 koob tshuaj. Thawj koob tshuaj thawj zaug tau nce ntxiv txog thaum qhov mob ploj zoo kiag li, qhov nruab nrab nce mus txog 400-800 mg ntawm carbamazepine ib hnub. Tom qab ntawd, hauv qee qhov ntawm cov neeg mob, kev kho mob tuaj yeem txuas ntxiv nrog kev kho qis dua ntawm 400 mg ntawm carbamazepine.
Finlepsin retard raug muab tshuaj rau cov neeg mob laus thiab cov neeg mob nkag rau karabamazepine hauv thawj koob 100 mg carbamazepine (1/2 ntsiav tshuaj 200 mg) 2 zaug hauv ib hnub.
Hnov mob ntshav qab zib neuropathy.
Qhov nruab nrab cov tshuaj txhua hnub yog 200 mg thaum sawv ntxov thiab 400 mg ntawm carbamazepine thaum yav tsaus ntuj. Hauv qee qhov tshwj xeeb, Finlepsin retard tuaj yeem muaj nyob rau hauv koob tshuaj 600 mg ntawm carbamazepine 2 zaug hauv ib hnub. Kab mob vwm uas huam ntau yam mob sclerosis.
Oh
Qhov nruab nrab txhua hnub koob tshuaj yog 400 - 800 mg ntawm carbamazepine, uas tau muab faib ua 2 koob tshuaj.
Kev kho thiab tiv thaiv kev mob hlwb
Thawj koob tshuaj thawj zaug, uas feem ntau sib haum rau ib koob tshuaj saib xyuas, yog 200-400 mg ntawm carbamazepine ib hnub. Yog tias tsim nyog, cov koob tshuaj no tuaj yeem raug nce rau 800 mg ntawm carbamazepine ib hnub, uas tau muab faib ua 2 koob tshuaj.
Lub sijhawm siv yog nyob ntawm qhov ntsuas thiab tus neeg teb ntawm tus neeg mob rau cov tshuaj. Epilepsy kho tau ntev. Tus kws kho mob tshwj xeeb yuav tsum txiav txim siab hloov chaw ntawm tus neeg mob mus rau Finlepsin retard, lub sijhawm siv thiab nws tshem tawm hauv txhua kis. Cov koob tshuaj ntawm cov tshuaj tuaj yeem txo los yog txiav kev kho kom tsis tu ncua tsis ntev ua ntej tom qab 2-3 xyoo qhaj tsis qaug dab peg.
Txoj kev kho tau raug tso tseg los ntawm kev txo qis zuj zus me me hauv lub sijhawm li 1-2 xyoo. Hauv qhov no, menyuam yuav tsum xav txog qhov nce hauv lub cev nyhav. Electroencephalogram ntsuas yuav tsum tsis txhob yaig.
Hauv kev kho mob ntawm neuralgia, nws raug nquahu kom muab Finlepsin retard nyob rau hauv ib koob tshuaj kom txaus kom txo qhov mob, rau ob peb lub lis piam. Los ntawm kev txo qis dua koob tshuaj, nws yog qhov tsim nyog kom pom qhov muaj peev xwm rov qab cov tsos mob. Nrog kev rov pib mob, kev kho mob txuas ntxiv nrog kev tswj hwm.
Lub sijhawm kho mob rau mob ntshav qab zib neuropathy thiab mob qaug dab peg hauv ntau yam sclerosis yog tib yam li rau neuralgia.
Finlepsin retard kev kho mob ntawm kev haus cawv haus cawv raug nres nrog kev maj mam txo qhov tsawg dua lub sijhawm 7-10 hnub.

Kev tiv thaiv kev nyab xeeb

Finlepsin Retard - cov tshuaj rau kev kho mob ntawm dibenzazepine series mob vwm. Nws muaj kev tiv thaiv kab mob, tshuaj tiv thaiv kev phom sij, vasopressin-zoo li kev txiav txim. Hauv cov tib neeg uas muaj qhov puas ntawm cov hlab ntaws, ua rau pom qhov txawv txav ntawm qhov mob ntawm qhov mob sab hauv ntawm txoj hlab ntsha, nws ua rau pom qhov ua kom tsis haum. Cov nyhuv pharmacological yog vim qhov tsis ua haujlwm ntawm voltage-rhiab sodium channel, vim qhov kev cuam tshuam ntawm cov roj ntsha ntawm qhov muaj siab ntau dhau ntawm cov neurons tau ruaj khov, cov cim ntawm ntau qhov sib txuas ntawm cov neurons thiab kev txiav txim ntawm cov pulses ntawm cov synapses yog suppressed. Nws txwv tsis pub glutamate, ib qho amino acid nrog txoj haujlwm ntawm lub neurotransmitter, los ntawm kev nkag mus hauv qhov chaw sib cais, thiab thawb lub hlwb ua kom qaug dab peg, yog li ua rau cov nyhuv antiepileptic. Txhawb nqa tus nquag nquag transmembrane thauj cov poov tshuaj ions. Hauv cov neeg kev txom nyem los ntawm kev mob vwm (feem ntau rau cov menyuam yaus thiab cov hluas), cov tshuaj txo cov kev ntxhov siab, qhov hnyav ntawm qhov mob tshwm sim tsis zoo, qhov kev npau taws poob qis, thiab kev ua kom ploj. Cov nyhuv ntawm kev paub ntawm kev ua si thiab lub siab lub ntsws kev xav tau txiav txim siab los ntawm cov koob tshuaj ntawm lub tshuaj. Qhov ua rau anticonvulsant pib tshwm sim nyob rau hauv thaj tsam li ntawm 3-4 teev mus rau ntau hnub (nyob rau qee qhov xwm txheej - txog 30 hnub). Nrog tus mob hangover, nws thawb rov qab pib qhov ua rau lub hlwb chua leeg, txo los ntawm kev haus dej cawv, tswj kev tshem tawm cov tsos mob tshem tawm (tshem tawm kev muaj zog ntau dhau, tsis tuaj yeem txav ntawm cov ntiv tes, li qub gait).

Cov nyhuv tshuaj tiv thaiv kab mob tshwm sim tom qab 7-10 hnub. Xws li qhov ntev ntawm kev pib siv tshuaj yaj yeeb hauv qhov kev qhia no yuav cuam tshuam nrog kev tsub ntawm dopamine thiab norepinephrine metabolism. Finlepsin Retard yog daim ntawv qhia txog kev noj tshuaj ntev ntev uas muab ib qib ruaj khov ntawm cov tshuaj nquag plasma nrog cov zaus ntawm kev tswj hwm ntawm 1-2 zaug hauv ib hnub. Nrog rau kev tswj hwm qhov ncauj ntawm cov tshuaj, cov tshuaj maj mam maj mam tab sis muaj siab rau hauv lub plab zom mov (muaj cov khoom noj hauv lub plab zom mov tsis muaj cov lus hais txog qhov ceev thiab ua kom tiav ntawm kev nqus). Kev ceev ntawm lub siab ua haujlwm hauv cov ntshav tau pom tias 32 teev tom qab kev coj noj coj ua. Ib nrab-lub neej thaj tsam li 70 teev. Kev tshem tawm los ntawm lub cev yog nqa tawm tsuas yog los ntawm lub raum thiab, kom tsawg dua, los ntawm cov hnyuv. Qhov zoo tshaj plaws kom tsawg lub sij hawm yog nrog los yog tam sim ntawd tom qab ib pluas noj. Nws raug tso cai ua ntej tshem tawm cov ntsiav tshuaj lossis ib feem ntawm nws hauv dej ua ntej kev tswj hwm: lub sijhawm ntawm cov tshuaj tsis raug kev txom nyem los ntawm qhov no. Tshaj tawm ntawm kev pub nkag - 1-2 zaug ib hnub. Lub chav kawm txog yeeb tshuaj yuav pib nrog kev noj tshuaj me txhua hnub nrog ntu nce ntxiv hauv nws kom txog thaum hais tawm los ntawm cov lus teb kho tau.

Kws Tshuaj

Cov tshuaj antiepileptic muab tau los ntawm tricyclic iminostilbene. Nws ntseeg tau hais tias cov nyhuv anticonvulsant cuam tshuam nrog txo qis ntawm kev muaj peev xwm ntawm neurons kom muaj qhov xwm txheej siab ntawm kev rov ua dua li qhov peev xwm ua los ntawm inactivation ntawm sodium channels. Tsis tas li ntawd, kev txwv tsis pub cov neurotransmitter tso tawm los ntawm thaiv cov hlab ntsha presynaptic sodium channel thiab kev txhim kho ntawm kev ua cov peev xwm, uas nyeg txo synaptic kis tau, zoo li yog qhov tseem ceeb.

Nws muaj cov tshuaj tiv thaiv kab mob ib nrab, tiv thaiv kev tawm tsam, nrog rau qhov ua kom xau rau qhov mob neurogenic. GABA receptors, uas tej zaum yuav cuam tshuam nrog calcium calcium channel, tej zaum yuav koom nrog cov txheej txheem ntawm kev ua, thiab cov nyhuv ntawm carbamazepine ntawm neurotransmitter modulator systems kuj zoo li tseem ceeb.

Qhov antidiuretic nyhuv ntawm carbamazepine tej zaum yuav cuam tshuam nrog hypothalamic ntxim rau osmoreceptors, uas tau sib kho los ntawm kev zais ntawm ADH, thiab kuj yog vim muaj kev cuam tshuam ncaj qha rau lub raum plab hlaub.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, carbamazepine yog yuav luag yaim los ntawm cov hnyuv. Kev khi rau cov ntshav plasma protein yog 75%. Nws yog qhov ua rau lub siab ua haujlwm ntawm daim siab thiab txhawb nws tus kheej hauv cov metabolism.

T 1/2 yog 12-29 teev. 70% yog tawm hauv cov zis (hauv kev siv lub cev tsis muaj zog) thiab 30% nrog quav.

Daim ntawv tso tawm

Cov ntsiav tshuaj siv ntev ntev los ntawm xim dawb mus dawb nrog lub ntsej muag daj, ua kom tiaj tus, tiaj tiaj, nrog cov npoo beveled, nrog cov kab uas pom kev ua txhaum ntawm ob sab thiab 4 nicks ntawm sab ntug.

Cov neeg muaj txiaj ntsig: ib qho copolymer ntawm ethyl acrylate, methyl methacrylate thiab trimethylammonioethyl methacrylate (1: 2: 0.1) (Eudragit RS30D), triacetin, talc, tus kws kho qhov muag ntawm methacrylic acid thiab ethyl acrylate (1: 1) (Eudragit L30c-crystalline) magnesium stearate.

10 Pcs - hlwv (5) - pob khoom ntawm cardboard.
10 Pcs - blister pob (5) - pob ntawv ntawm cardboard.
10 Pcs - blister packs (3) - pob ntawv ntawm cardboard.
10 Pcs - hlwv pob (4) - pob khoom los ntawm cardboard.

Nruab ib tus zuj zus. Thaum noj ntawm qhov ncauj rau cov laus thiab cov hluas hnub nyoog 15 xyoo thiab laus dua, qhov koob tshuaj thawj zaug yog 100-400 mg. Yog tias tsim nyog, thiab coj mus rau hauv qhov kev sim tshuaj, cov tshuaj tau nce siab tsis ntau tshaj 200 mg / hnub nrog kev ncua sij hawm ntawm 1 lub lis piam. Qhov ntau zaus ntawm kev tswj hwm yog 1-4 zaug / hnub. Cov koob tshuaj saib xyuas feem ntau yog 600-1200 mg / hnub hauv ntau koob. Lub sijhawm kho yog nyob ntawm qhov ntsuas, qhov ua tau ntawm kev kho, tus neeg mob cov lus teb rau kev kho.

Hauv cov menyuam muaj hnub nyoog qis dua 6 xyoo, 10-20 mg / kg / hnub siv nyob rau hauv 2-3 koob tshuaj sib cais, yog tias tsim nyog thiab coj mus rau hauv qhov kev nkag siab, qhov kev sib tw tau nce tsis ntau tshaj 100 mg / hnub nrog ncua sijhawm 1 lub lis piam, txij nkawm tshuaj feem ntau yog 250 -350 mg / hnub thiab tsis pub tshaj 400 mg / hnub. Cov menyuam hnub nyoog 6-12 xyoo - 100 mg 2 zaug / hnub rau thawj hnub, tom qab ntawd cov koob tshuaj tau nce ntxiv los ntawm 100 mg / hnub nrog ncua sijhawm 1 lub lis piam. kom txog rau thaum cov nyhuv zoo tshaj, kev txij nkawm feem ntau yog 400-800 mg / hnub.

Cov koob tshuaj ntau tshaj plaws: thaum noj ntawm qhov ncauj, cov laus thiab cov hluas 15 xyoo thiab laus dua - 1.2 g / hnub, cov menyuam - 1 g / hnub.

Kev sib txuam

Nrog rau kev siv ua ke ntawm cov tshuaj tiv thaiv ntawm isoenzyme CYP3A4, kev nce ntxiv ntawm kev nkag siab ntawm carbamazepine hauv cov ntshav ntshav yog ua tau.

Nrog rau kev siv sib txuam ntawm cov inducers ntawm CYP3A4 isoenzyme system, kev ua kom sai ntawm cov metabolism ntawm carbamazepine, qhov kev txo qis hauv nws cov concentration hauv cov ntshav ntshav, thiab qhov txo qis hauv kev kho mob yog qhov ua tau.

Nrog rau kev siv carbamazepine tib lub sij hawm stimulates cov metabolism ntawm anticoagulants, folic acid.

Nrog rau kev siv ib txhij nrog valproic acid, qhov txo qis hauv kev mloog ntawm carbamazepine thiab qhov tseem ceeb txo qis ntawm kev cuam tshuam ntawm valproic acid nyob rau hauv cov ntshav ntshav yog ua tau. Nyob rau tib lub sijhawm, qhov kev coj ua ntawm carbamazepine metabolite, carbamazepine epoxide, nce (tej zaum vim yog qhov inhibition ntawm nws hloov mus rau carbamazepine-10,11-trans-diol), uas kuj muaj cov dej ua anticonvulsant, yog li cov txiaj ntsig ntawm qhov kev sib txuam no tuaj yeem ua rau qib, tab sis cov kev tsis haum siab feem ntau tshwm sim - qhov muag plooj, kiv taub hau, ntuav, tsis muaj zog, nystagmus. Nrog rau kev siv cov valproic acid thiab carbamazepine tib lub sijhawm, kev txhim kho ntawm hepatotoxic nyhuv muaj peev xwm ua tau (thaj, vim muaj kev tsim cov khoom noj ntawm lub cev tshiab ntawm valproic acid, uas muaj cov kab mob hepatotoxic).

Nrog rau siv ua ke, valpromide txo qis cov metabolism hauv lub siab carbamazepine thiab nws cov metabolite carbamazepine-epoxide vim yog kev thaiv cov enzyme epoxide hydrolase. Cov kev teeb txheeb metabolite muaj cov kev ua haujlwm anticonvulsant, tab sis nrog qhov nce ntxiv ntawm plasma concentration nws tuaj yeem muaj cov nyhuv tsis zoo.

Nrog rau kev siv ua ke nrog verapamil, diltiazem, isoniazid, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazole, desipramine, nicotinamide (hauv cov neeg laus, tsuas yog hauv koob tshuaj ntau), erythromycin, trlecymero, trcin, jircinero, trcincin, mob suav nrog nrog itraconazole, ketoconazole, fluconazole), terfenadine, loratadine, kev nce siab ntawm cov carbamazepine hauv ntshav plasma muaj peev xwm muaj kev pheej hmoo ntawm phiv (kiv taub hau, tsaug zog, ataxia, diplopia).

Nrog rau kev siv tib lub sijhawm nrog hexamidine, cov tshuaj anticonvulsant ntawm carbamazepine tsis muaj zog, nrog hydrochlorothiazide, furosemide - nws muaj peev xwm txo cov sodium ntsiab lus hauv cov ntshav, nrog rau kev tiv thaiv tshuaj hormonal - nws yog qhov ua tau kom tsis muaj zog ntawm kev tiv thaiv thiab kev txhim kho ntawm acyclic los ntshav.

Nrog rau kev siv ib txhij nrog cov thyroid hormones, nws muaj peev xwm nce kev tshem tawm cov thyroid hormones, nrog clonazepam, nws yog qhov ua tau kom nce qhov tshem ntawm clonazepam thiab txo qhov tshem ntawm carbamazepine, nrog lithium npaj, kev sib nrig sib ntxiv ntawm cov nyhuv neurotoxic tau.

Nrog rau kev siv ua ke nrog primidone, ib qho kev txo qis hauv kev mloog ntawm carbamazepine hauv cov ntshav ntshav yog ua tau. Muaj cov ntaub ntawv hais tias primidone tuaj yeem ua rau lub plasma concentration ntawm qhov tshuaj pharmacologically nquag metabolite - carbamazepine-10,11-epoxide.

Nrog rau kev siv nrog ritonavir, kev mob tshwm sim ntawm carbamazepine tuaj yeem ua kom zoo dua qub, nrog sertraline, qhov kev poob qis ntawm sertraline yog ua tau, nrog theophylline, rifampicin, cisplatin, doxorubicin, qhov txo qis ntawm carbamazepine hauv ntshav ntshav, nrog tetracycline, cuam tshuam ntawm carbamam.

Nrog rau kev siv nrog felbamate, qhov kev txo qis hauv cov ntsiab lus ntawm carbamazepine nyob rau hauv cov ntshav ntshav yog qhov ua tau, tab sis kev nce siab hauv kev cuam tshuam ntawm cov nquag metabolite ntawm carbamazepine-epoxide, thaum txo qis hauv kev saib xyuas hauv lub plasma ntawm felbamate yog ua tau.

Nrog rau kev siv ua ke nrog phenytoin, phenobarbital, qhov concentration ntawm carbamazepine hauv cov ntshav ntshav poob qis. Kev sib nrig tsis muaj zog ntawm cov tshuaj tiv thaiv anticonvulsant ua tau, thiab qee zaus, nws txoj kev ua kom muaj zog.

Sab sij huam

Los ntawm ib sab ntawm lub hauv nruab nrab lub paj hlwb thiab peripheral lub paj hlwb: feem ntau - kiv taub hau, ataxia, tsaug zog, mob taub hau tau, diplopia, kev cuam tshuam kev cuam tshuam, tsis tshua muaj - kev tsis tuaj yeem txav, nystagmus, nyob rau qee kis - oculomotor cuam tshuam, dysarthria, peripheral neuritis, paresthesia, leeg tsis muaj zog, cov tsos mob paresis, pom kev xav, kev nyuaj siab, nkees, txhoj puab heev, ntxhov siab, tsis nco qab lawm, nce siab, ua kom mob hlwb, saj tsis taus, mob txhaws, paj hlwb, hyperacusis.

Los ntawm lub plab zom mov: xeev siab, nce GGT, nce kev ua si ntawm alkaline phosphatase, ntuav, lub qhov ncauj qhuav, tsis tshua - muaj kev ua si ntau dua ntawm transaminases, mob daj ntseg, cholestatic mob siab, mob raws plab lossis quav tawv, qee qhov - tsis tshua qab los noj mov, mob plab, glossitis, mob plab.

Los ntawm cov hlab plawv: tsis tshua muaj tshwm sim - myocardial conduction cuam tshuam, qee qhov - bradycardia, arrhythmias, AV blockade nrog syncope, vau, lub plawv tsis ua haujlwm, tshwm sim ntawm kev tsis pom kev ntawm lub plawv, thrombophlebitis, thromboembolism.

Los ntawm cov kab mob hemopoietic: leukopenia, eosinophilia, thrombocytopenia, tsis tshua muaj - leukocytosis, nyob rau qee kis - agranulocytosis, mob ntshav tsis txaus, erythrocytic aplasia, megaloblastic anemia, meicoblastic anemia, reticulocytosis, hemolytic anemia, granulomatous heemia.

Los ntawm ib sab ntawm cov metabolism: hyponatremia, kua dej tsis sib haum, edema, hnyav nce, txo ntshav plasma osmolality, qee kis - mob sib kis ceev, mob ntshav qab zib, folic acid tsis txaus, calcium metabolism tsis txaus, nce roj thiab triglycerides.

Los ntawm cov kab mob endocrine: gynecomastia lossis galactorrhea, tsis tshua muaj - kev ua haujlwm ntawm cov thyroid.

Los ntawm cov kab mob txeeb zis: tsis tshua muaj - mob raum lub raum, interstitial nephritis thiab lub raum tsis ua haujlwm.

Los ntawm cov txheej txheem ua pa: hauv qee kis - dyspnea, mob ntsws lossis mob ntsws.

Ua xua: ua pob khaus tawv, khaus, tsis tshua muaj - lymphadenopathy, ua npaws, mob hepatosplenomegaly, mob caj dab.

Epilepsy: loj, focal, sib xyaw (suav nrog kev loj thiab loj) epileptic qaug dab peg. Cov tsos mob mob feem ntau ntawm keeb kwm neurogenic, suav nrog qhov tseem ceeb trigeminal neuralgia, trigeminal neuralgia nyob rau hauv ntau yam sclerosis, qhov tseem ceeb glossopharyngeal neuralgia. Kev tiv thaiv ntawm kev tawm tsam nrog rau haus dej haus cawv kom tshem tawm. Cuam tshuam thiab schizoaffective psychoses (raws li kev tiv thaiv). Mob neuropathy mob nrog rau mob. Ntshav qab zib insipidus ntawm lub hauv paus pib, polyuria thiab polydipsia ntawm neurohormonal xwm.

Cev xeeb tub thiab lactation

Yog tias tsim nyog, siv thaum cev xeeb tub (tshwj xeeb tshaj yog nyob rau thawj peb hlis) thiab lub sijhawm lactation yuav tsum ua tib zoo ntsuas cov txiaj ntsig ntawm kev kho mob rau leej niam thiab kev pheej hmoo rau tus menyuam lossis menyuam. Hauv qhov no, carbamazepine raug pom zoo kom siv tsuas yog kev kho mob monotherapy hauv kev siv koob tshuaj tsawg kawg nkaus.

Cov poj niam ntawm lub hnub nyoog yug menyuam thaum lub sijhawm kho nrog carbamazepine raug pom zoo kom siv cov tshuaj tsis xeeb menyuam.

Cov lus qhia tshwj xeeb

Carbamazepine tsis yog siv rau atypical lossis dav dav me mob qaug dab peg, myoclonic lossis atonic epileptic qaug dab peg. Nws yuav tsum tsis txhob siv los daws qhov mob ib txwm, ua rau lub caij nyoog ntev ntawm kev tshem tawm ntawm trigeminal neuralgia.

Nws yog siv nrog ceev faj thaum muaj cov kab mob tsis ua haujlwm ntawm cov hlab plawv, mob siab rau lub siab thiab / lossis lub raum kev ua haujlwm, mob ntshav qab zib mellitus, muaj kev mob siab rau lub cev, muaj keeb kwm ntawm cov ntshav hloov mus rau kev siv lwm yam tshuaj, hyponatremia, tso zis cia, thiab nce siab rau tricyclic antidepressants , nrog cov cim qhia txog keeb kwm kev cuam tshuam ntawm kev kho carbamazepine, nrog rau cov menyuam yaus thiab cov neeg laus laus.

Txoj kev kho yuav tsum tau ua nyob ntawm kev saib xyuas ntawm kws kho mob. Nrog rau kev kho mob ntev, nws yog ib qho tsim nyog los tswj cov ntshav ntshav, lub xeev ua haujlwm ntawm lub siab thiab lub raum, cov tshuaj electrolytes hauv cov ntshav ntshav, thiab kev kuaj xyuas ophthalmological. Kev txiav txim siab ntu ntawm qib carbamazepine nyob rau hauv cov ntshav ntshav yog pom zoo kom saib xyuas qhov ua tau zoo thiab kev nyab xeeb ntawm kev kho.

Tsawg kawg 2 lub lis piam ua ntej pib kho carbamazepine, nws yog ib qho tsim nyog yuav tsum tau txiav kev kho mob nrog MAO inhibitors.

Thaum lub sijhawm kho tsis pub haus cawv.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Thaum kho, ib qho yuav tsum tsis txhob koom nrog cov kev ua phom sij uas yuav tsum muaj kev saib xyuas ntxiv, thiab qhov ceev ntawm lub cev kev xav.

chaw muag tshuaj Cov. Finlepsin retard yog ib qho tshuaj anticonvulsant derivative ntawm tricyclic iminostilbene. Nws ua rau pom kev ua haujlwm antiepileptic, ua haujlwm ntawm neurotropic thiab psychotropic. Cov txiaj ntsig kho feem ntau yog los ntawm kev tsis sib xws ntawm kev xa xov ntawm kev ua kom zoo thiab vim li ntawd, qhov txo qis ntawm kev sib kis ntawm kev tawm tsam. Thaum muaj kev cuam tshuam ntau dua, carbamazepine ua rau muaj kev txo qis rau tom qab kev ua kom muaj zog. Finlepsin retard txo qhov hnyav ntawm qhov mob ntawm trigeminal neuralgia. Cov nyhuv no yog vim yog inhibition ntawm lub synaptic kis ntawm kev ua kom mob siab rau hauv tus txha nqaj qaum ntawm tus mob trigeminal. Nrog rau ntshav qab zib insipidus, Finlepsin retard muaj cov nyhuv antidiuretic, tejzaum nws vim muaj kev cuam tshuam hypothalamic ntawm osmoreceptors.

Cov Tshuaj Pharmacokinetics Tom qab kev tswj hwm ntawm qhov ncauj, carbamazepine yog nqus maj mam thiab yuav luag ua tiav.

Lub sijhawm ib nrab-lub neej yog 8,5 teev thiab muaj ntau yam (txog 1.72-12 teev). Tom qab txhaj koob tshuaj C ib zaug, carbamazepine nyob rau hauv cov ntshav ntshav hauv cov neeg laus tau tiav tom qab 4-16 teev (feem ntau tsis tshua muaj sijhawm tom qab 35 teev), hauv cov menyuam yaus tom qab txog 4-6 teev. Qhov siab ntawm carbamazepine hauv ntshav ntshav tsis yog linearly koob tshuaj, thiab, thiab thaum siv nyob rau hauv ntau dua koob, lub plasma concentration curve muaj daim ntawv ntawm toj siab.

Thaum lub caij nyoog ntev-tso cov ntsiav tshuaj siv, qhov qis qis ntawm carbamazepine hauv cov ntshav ntshav yog ua tiav ntau dua nrog cov ntsiav tshuaj muaj txiaj ntsig.

Kev ua kom sib npaug sib luag tau zoo tom qab 2-8 hnub. Tsis muaj qhov sib txuam ze ntawm cov koob tshuaj carbamazepine thiab cov kev ruaj khov nyob hauv kev sib luag hauv cov ntshav ntshav.

Hais txog kev kho mob thiab tshuaj lom ntau ntawm carbamazepine hauv ntshav ntshav, nws yog qhov qhia tau tias qaug dab peg yuav ploj nrog cov ntshav ntshav ntawm 4-12 μg / ml. Qhov tob ntawm cov tshuaj nyob rau hauv cov ntshav ntshav hauv ntau tshaj 20 μg / ml, zuj zus daim duab ntawm tus kab mob.

Finlepsin retard ntawm kev saib xyuas ntawm cov tshuaj txuam hauv cov ntshav ntshav ntawm 5-18 μg / ml tshem tawm qhov mob ntawm trigeminal neuralgia.

70-80% ntawm carbamazepine khi rau cov ntshav muaj protein ntau. Ib feem ntawm carbamazepine tsis muaj kev cuam tshuam nrog cov protein ntawm qhov ntau ntawm 50 μg / ml tseem nyob tas li. 48-53% ntawm cov tshuaj pharmacologically nquag metabolite carbamazepine-10, 11-epoxide khi rau cov ntshav protein. Qhov kev nyeem ntawm carbamazepine hauv CSF yog 33% ntawm lub plasma concentration.

Carbamazepine hla lub plab placental thiab tawm hauv cov kua mis.

Tom qab noj ib koob tshuaj, carbamazepine raug cais tawm los ntawm cov ntshav ntshav nrog T ½ 36 teev. Nrog rau kev kho mob ntev, T ½ poob qis los ntawm 50% vim yog qhov induction ntawm microsomal daim siab enzymes.

Hauv cov tib neeg muaj kev noj qab haus huv, kev tshem tawm tag nrho los ntawm cov ntshav ntshav yog li 19.8 ml / h / kg lub cev hnyav, hauv cov neeg mob monotherapy - txog 54.6 ml / h / kg, hauv cov neeg mob nrog kev kho ua ke - txog 113.3 ml / h / kg

Tom qab ib qho kev tswj hwm qhov ncauj ntawm carbamazepine, 72% ntawm cov koob tshuaj nyob rau hauv daim ntawv ntawm metabolites yog tawm hauv lub cev los ntawm lub raum. Qhov seem 28% yog tawm nrog rau cov quav, qee ntawm - tsis hloov. Tsuas yog 2-3% ntawm ib qhov tshuaj tawm nyob rau hauv cov zis yog carbamazepine tsis hloov pauv.

epilepsy: qaug dab peg los sis ib nrab ntawm cov qaug dab peg (nrog lossis tsis nco qab txiav txim siab) nrog lossis tsis muaj kev xam phaj theem ob, feem ntau tonic-clonic qaug dab peg, sib xyaw ntawm cov qaug dab peg.

Finlepsin retard tuaj yeem siv tau ob qho tib si li monotherapy thiab ua ib feem ntawm kev sib xyaw ua ke.

Mob manic zoo, txhawb kev kho mob rau kev puas siab mob bipolar txhawm rau tiv thaiv kev ua kom tsis txhob raug mob lossis kom txo qis ntawm qhov kev ua kom pom mob ntawm exacerbation.

Cov tsos mob ntawm kev haus cawv.

Idiopathic trigeminal neuralgia thiab trigeminal neuralgia hauv ntau yam sclerosis (feem ntau thiab atypical).

Idiopathic neuralgia ntawm lub paj hlwb glossopharyngeal.

Finlepsin retard yog kho mob ntawm qhov ncauj, feem ntau koob tshuaj txhua hnub yuav tsum tau faib ua 2 koob. Koj tuaj yeem noj cov tshuaj nyob hauv sijhawm, tom qab noj mov lossis nruab nrab ntawm pluas noj, nrog me me ntawm cov kua.

Ua ntej pib txoj kev kho mob, cov neeg mob uas yog haiv neeg ntawm haiv neeg Suav Han lossis cov neeg mob Thaib keeb kwm yuav tsum, yog tias ua tau, yuav raug kuaj rau HLA-B * 1502, vim tias qhov allele tuaj yeem ua rau muaj kev cuam tshuam loj ntawm cov kab mob Stevens-Johnson mob.

Tshuaj qaug dab peg Kev kho mob pib nrog kev siv tshuaj ntawm txhua hnub tsawg, uas tom qab ntawd maj mam nce ntxiv (kho, coj mus rau hauv qhov xav tau ntawm txhua tus neeg mob) kom txog thaum pom cov txiaj ntsig zoo tshaj plaws.

Nyob rau hauv rooj plaub uas qhov no ua tau, Finlepsin retard yuav tsum muaj kev kho mob raws li kev kho mob monotherapy, tab sis thaum siv nrog lwm cov tshuaj, kev hloov kho ntawm tib lub nce zuj zus hauv lub koob tshuaj tau pom zoo. Yog tias Finlepsin retard ntxiv rau qhov kev kho mob antiepileptic uas twb muaj lawm, cov koob tshuaj yuav tsum tau nce ntxiv zuj zus, thaum cov koob tshuaj ntawm cov tshuaj siv tsis hloov pauv lossis kho yog tsim nyog.

Txhawm rau xaiv cov tshuaj noj kom zoo dua hauv cov tshuaj, nws yuav muaj txiaj ntsig los txiav txim siab theem ntawm cov tshuaj nquag hauv cov ntshav ntshav. Kev kho mob siab rau ntawm cov tshuaj hauv ntshav ntshav yuav tsum yog 4-12 μg / ml.

Hauv qee cov neeg mob, nrog kev siv cov ntsiav tshuaj noj qab haus huv, nws yuav tsim nyog yuav tsum tau nce ntxiv ntawm cov tshuaj.

Cov neeg laus Qhov pom zoo pib koob yog 100-200 mg 1-2 zaug hauv ib hnub, tom qab ntawd cov koob tshuaj tau maj mam nce kom txog thaum qhov txiaj ntsig zoo tshaj plaws, feem ntau cov tshuaj txhua hnub yog 800-1200 mg, uas tau muab faib ua 2 koob. Qee tus neeg mob yuav tsum tau txhaj tshuaj Finlepsin retard ncav cuag 1600 mg lossis txawm tias 2000 mg / hnub.

Cov neeg laus cov neeg mob. Muab cov tshuaj sib cuam tshuam thiab sib txawv ntawm cov tshuaj antiepileptic, cov neeg laus yuav tsum tau xaiv nrog ceev faj hauv finlepsin retard koob tshuaj.

Cov menyuam yaus txij hnub nyoog 5 xyoos. Feem ntau, kev kho mob yuav tsum tau nqa tawm ntawm koob tshuaj 10-20 mg / kg lub cev qhov hnyav ib hnub (hauv ob peb zaug).

Cov menyuam yaus hnub nyoog 5-10 xyoo - 400-600 mg / hnub.

Cov menyuam yaus hnub nyoog 10-15 - 600-1000 mg / hnub.

Mob manic thiab kev pab txhawb kev kho mob los ntawm qhov muaj mob (bipolar). Cov tshuaj ntau npaum li cas yog 400-1600 mg / hnub hauv 2 faib ua ntau.

Feem ntau, kev kho mob yog nqa tawm ntawm ib koob ntawm 400-600 mg / hnub hauv 2 faib tshuaj. Hauv kev kho mob ntawm qhov mob manic zoo, koob tshuaj ntawm Finlepsin retard yuav tsum tau nce ntau nrawm rau 800 mg / hnub. Nrog kev kho kom zoo rau kev puas siab puas ntsws bipolar, maj mam nce siab hauv kev noj tshuaj tsawg kawg yog pom zoo kom muaj kev pom zoo zoo tshaj plaws.

Cawv kev haus dej haus cawv. Qhov nruab nrab koob tshuaj yog 600 mg / hnub hauv 2 koob faib. Hauv cov xwm txheej loj, cov koob tshuaj muaj peev xwm nce ntxiv nyob rau thawj ob peb hnub (piv txwv, nce txog 1200 mg / hnub, muab faib ua 2 koob tshuaj). Hauv kev tshwm sim ntau yam ntawm kev haus cawv, kev kho mob pib nrog kev sib ntxiv ntawm Finlepsin retard nrog cov tshuaj sedative-hypnotic (piv txwv li, clomethiazole, chlordiazepoxide), ua raws li cov lus qhia muab tshuaj rau saum toj no. Tom qab cov theem mob ua tiav tiav, kev kho nrog Finlepsin retard tuaj yeem txuas ntxiv ua kev kho mob monotherapy.

Idiopathic trigeminal neuralgia thiab trigeminal neuralgia hauv ntau yam sclerosis (feem ntau thiab atypical). Idiopathic neuralgia ntawm lub paj hlwb glossopharyngeal. Thawj koob tshuaj ntawm Finlepsin Retard yog 200-400 mg / hnub (100 mg 2 zaug ib hnub rau cov neeg laus). Nws yuav tsum maj mam nce ntxiv kom txog thaum qhov mob ploj mus (feem ntau muaj txog li ntawm 400-800 mg, muab faib ua 1-2 zaug). Qee qhov xwm txheej, koob tshuaj txhua hnub ntawm 1600 mg yuav tsum tau ua. Tom qab qhov tas tas ntawm qhov mob, qhov koob tshuaj yuav tsum maj mam txo kom tsawg kawg kev txij nkawm.

Finlepsin Retard yuav tsum tsis txhob kho:

• nrog tsim kev tiv thaiv hypersensitivity rau carbamazepine lossis tshuaj zoo sib xws (tricyclic antidepressants), lossis lwm yam tshuaj ntawm cov tshuaj,
• nrog AV thaiv,
• keeb kwm ntawm inhibition ntawm cov hlwb pob txha muaj nuj nqi,
• cov neeg mob uas muaj keeb kwm ntawm hepatic porphyria (piv txwv li, muaj kab mob sib kis, muaj kab mob sib xyaw ua ke, tawv nqaij ua kom tawv nqaij),
• nrog MAO inhibitors,
• txuam nrog voriconazole, raws li kev kho mob tej zaum yuav tsis muaj txiaj ntsig.

cov kev mob tshwm sim feem ntau tshwm sim nrog kev kho mob ntau dua nrog kev kho mob hlwb. Ua raws li cov koob tshuaj thiab feem ntau thaum pib kho, qee qhov kev mob tshwm sim yuav tshwm sim. Feem ntau, lawv ploj lawv tus kheej tom qab 8-14 hnub lossis tom qab txo cov tshuaj nyob ib ntus.

Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: leukocytosis, eosinophilia, leukopenia, thrombocytopenia, folic acid deficiency, agranulocytosis, aplastic anemia, pancytopenia, erythrocytic aplasia, anemia, megaloblastic anemia, mob ntshav sib luag hauv lub cev, muaj mob rau cov tawv nqaij txha nqaj ntshav.

Los ntawm lub nruab zog: cov pob mob ua pob nrog eosinophilia thiab cov tsos mob ntawm lub cev (DRESS), ncua sijhawm ntau lub cev ua rau muaj qhov kub taub hau, tawm pob ntawm daim tawv nqaij, mob vasculitis, lymphadenopathy, cov tsos mob zoo li mob qog, mob ntshav siab, ntau yam mob rau lub siab. bile ducts (kev puas tsuaj thiab ploj ntawm cov mob plab hauv lub plab), mob aseptic rau daim tawv nqaij myoclonus thiab peripheral eosinophilia, anaphylactic cov tshuaj tiv thaiv, mob caj dab, mob ntshav qab zib qog ntshav ntshav. Lwm yam khoom hauv nruab nrog (piv txwv, daim siab, lub ntsws, lub raum, tus neeg mob raum, myocardium, plab hnyuv loj) kuj yuav koom nrog.

Los ntawm cov kab ke endocrine: edema, tso kua mis tawm, hnyav ntxiv, hyponatremia thiab txo ntshav plasma osmolarity los ntawm cov nyhuv ntawm carbamazepine, zoo ib yam li kev ua ntawm antidiuretic hormone, uas qee zaum ua rau lub cev tsis muaj zog, uas yog nrog ua kom nkees, ntuav, mob taub hau, tsis meej pem thiab mob hlwb, nce qib ntawm prolactin nrog lossis tsis muaj cov tsos mob hauv chaw kho mob xws li galactorrhea thiab gynecomastia, cov txiaj ntsig tsis zoo ntawm cov tshuaj ntsuas thyroid muaj nuj nqi: qhov kev txo qis ntawm L-thyroxine (FT 4, T 4, T 3) thiab nce TSH, uas feem ntau yuav ploj mus yam tsis muaj kev soj ntsuam, kev ua kom tsis muaj pob txha hauv lub cev (txo ntshav plasma calcium thiab 25-hydroxycolecalciferol hauv cov ntshav ntshav, uas ua rau cov txha ntshav / osteoporosis, nce ntxiv hauv cholesterol, suav nrog HDL cov roj (cholesterol) thiab triglycerides) Carbamazepine tuaj yeem txo plasma ntshav folate Kev txo qis ntshav plasma ntau ntawm cov vitamin B 12 nyob rau hauv kev cuam tshuam ntawm carbamazepine thiab ib qho kev nce qib hauv homocysteine ​​kuj tau raug tshaj tawm.

Los ntawm sab ntawm cov metabolism thiab noj zaub mov tsis haum: folate deficiency, tsis qab los noj mov, muaj pob qij txha ntev, mob hnyuv txhaws ntev.

Los ntawm ib sab ntawm lub psyche: pom kev zoo (pom lossis hnov ​​lus), kev nyuaj siab, tsis muaj qab los noj mov, ntxhov siab, coj tus cwj pwm txawv, ntxhov siab, ntxhov siab ntxhov plawv, tsis meej pem, kev mob hlwb tsis meej, kev hloov pauv hauv siab, xws li mob siab lossis mob siab hloov pauv, phobias, tsis muaj kev txhawb zog, ua tsis taus, xws li asterixis.

Los ntawm lub paj hlwb: cov kev ua kom tsis muaj zog, kiv taub hau, ataxia, tsaug zog, qaug zog, qaug zog, mob taub hau, mob duav hloov pauv (piv txwv li kev co, co co co, dystonia, tic), nystagmus, orofacial dyskinesia, maj mam xav, hais lus tsis meej (piv txwv li dysarthria lossis hais lus tsis meej), choreoathetosis, peripheral neuropathy, paresthesia, leeg tsis muaj zog thiab paresis, saj tsis taus, malignant antipsychotic syndrome, nco tsis meej, ataxic thiab cerebellar ntshawv siab, uas qee zaum nrog mob taub hau huag mob.

Los ntawm sab ntawm cov khoom ntawm lub zeem muag: pom kev tsis meej, kev pab cuam tsis zoo (daim ntawv pov thawj tsis pom kev, qhov muag plooj), lub zog ua rau lub siab, kaw lub ntsej muag, thim rov qab, muaj kev cuam tshuam.

Ntawm ib feem ntawm cov khoom hauv nruab nrab ntawm lub rooj sib hais thiab cov khoom siv vestibular: hnov lus tsis zoo, tinnitus, tinnitus, hyperacusis, hypoacusia, hnov ​​qhov tsis pom lub suab.

Los ntawm cov kab mob plawv: kev phais mob ntawm lub cev, kev nyuaj siab, dhia tsis meej, mob hnyav ntawm lub plawv, mob plawv tsis txaus, lub plawv tawg, ntshav tawg, AV txhaws nrog syncope, tawg lossis hypotension, vasculitis, thrombophlebitis, thromboembolism (e.g. pulmonary embolism).

Kev mob siab ntsws los ntawm lub ntsws, uas yog tus cwj pwm los ntawm kev nce hauv lub cev kub, ua pa luv, mob ntsws los yog mob ntsws. Thaum muaj qhov tshwm sim hypersensitivity, cov tshuaj yuav tsum nres.

tsis qab los noj mov, qhov ncauj qhuav, xeev siab, ntuav, raws plab, cem quav, mob plab, stomatitis, gingivitis, glossitis, pancreatitis, colitis.

Hepatobiliary mob: cov kev pauv hauv qhov ntsuas ntawm daim siab ua haujlwm (nce qib ntawm gamma-glutamyl transferase, nce ntau ntawm alkaline phosphatase, transaminases), daj ntseg, ntau yam mob muaj kab mob siab (cholestatic, hepatocellular, granulomatous, sib xyaw ua ke), lub neej muaj kev tiv thaiv kab mob siab, mob ntshav siab.

Ntawm feem ntawm daim tawv nqaij thiab cov rog rog subcutaneous: dermatitis kev tsis haum, urticaria, pruritus, exfoliative dermatitis, erythroderma, necrosis ntawm daim tawv nqaij tsis muaj tawv nqaij (Lyell's syndrome), photosensitivity, reddening ntawm daim tawv nqaij nrog cov pob txha mos polymorphic nyob rau hauv daim ntawv ntawm me ntsis thiab tsim cov ntshav, nrog hemorrhages (exudative erythema multiform) Stevens-Johnson), kev mob ntshav hauv cov tawv nqaij thiab lupus erythematosus (nthuav tawm lupus erythematosus, alopecia), diaphoresis, hloov pauv ntawm daim tawv nqaij ua pob, ua pob, hirsutism, vasculitis, pu Pura, nce tawm hws, mob generalized exanthematous pustulosis (AGEP), lichenoid keratosis, onihomadez.

Los ntawm cov leeg musculoskeletal: arthralgia, myalgia, mob nqaij pob txha, mob leeg, mob pob txha, pob txha pob txha qhov tsawg.

Los ntawm ob lub raum thiab mob txeeb zig: proteinuria, hematuria, oliguria, dysuria, pollakiuria, tso zis cia, tubulointerstitial nephritis, lub raum tsis ua haujlwm, ntshav urea / azotemia, tso zis heev.

Los ntawm kev muaj me nyuam thiab qog mammary qog: kev ua txhaum ntawm cov phevatogenesis (nrog rau tus naj npawb thiab / lossis kev muaj lub zog los ntawm spermatozoa), mob erectile kawg, impotence, txo qis kev sib deev muaj siab.

Cov kab mob thiab kis: kev thiav ntawm tib neeg mob hom pob.

Kev sib txawv ntawm cov chaw kuaj sim: hypogammaglobulinemia.

carbamazepine yuav tsum raug saib xyuas tsuas yog nyob hauv kev saib xyuas kev noj qab haus huv, tsuas yog tom qab ntsuas qhov txiaj ntsig / qhov phom sij piv thiab yuav ua tib zoo saib xyuas cov neeg mob uas muaj keeb kwm mob plawv, mob rau lub siab lossis mob raum, mob ntshav tsis zoo rau lwm cov tshuaj, lossis cov neeg mob uas cuam tshuam kev kho carbamazepine.

Carbamazepine ua pov thawj me ntsis kev ua si anticholinergic, yog li ntawd, cov neeg mob uas muaj kev cia siab ntxiv yuav tsum ceeb toom thiab sab laj txog qhov yuav muaj kev phom sij.

Nws yuav tsum nco ntsoov txog qhov ua tau ua kom muaj mob hlwb latent, thiab muaj kev cuam tshuam nrog cov neeg mob laus - txog qhov ua tau kom rov ua haujlwm tsis meej pem thiab tsim kev ntxhov siab.

Cov tshuaj feem ntau tsis muaj txiaj ntsig rau qhov tsis tuaj kawm (mob me me) thiab myoclonic qaug dab peg. Qee qhov xwm txheej qhia tau hais tias nce chua leeg ntxiv tuaj yeem tshwm sim hauv cov neeg mob uas tsis tuaj yeem atypical.

Hematologic cuam tshuam. Kev siv cov tshuaj muaj feem cuam tshuam nrog kev txhim kho ntawm agranulocytosis thiab aplastic anemia, tab sis vim muaj qhov tshwm sim tsis tshua muaj tshwm sim ntawm cov mob no, nws nyuaj rau kev ntsuam xyuas qhov kev pheej hmoo tseem ceeb thaum noj cov carbamazepine.

Cov neeg mob yuav tsum raug qhia paub txog cov cim ua ntej ntawm kev mob toxicity thiab cov tsos mob ntawm cov mob hematologic, nrog rau cov tsos mob tshwm sim ntawm daim tawv nqaij thiab lub siab. Tus neeg mob yuav tsum raug ceeb toom tias thaum muaj kev tshwm sim xws li kub ib ce, mob caj pas, tawm pob ntawm daim tawv nqaij, mob rau ntawm qhov ncauj, doog ntshav uas yooj yim tshwm sim, pinpoint hemorrhages lossis hemorrhagic purpura, koj yuav tsum sab laj nrog kws kho mob tam sim ntawd.

Yog tias muaj pes tsawg tus leukocytes lossis platelets txo qis thaum lub sijhawm kho, tus neeg mob yuav tsum tau ua tib zoo saib xyuas, thiab ib qho kev kuaj ntshav tas li ntawm tus neeg mob yuav tsum tau ua. Kev kho mob nrog carbamazepine yuav tsum tsis ua mus ntxiv yog hais tias tus neeg mob pib mob leukopenia, uas yog mob hnyav, nce zuj zus, lossis nrog cov lus tshawb pom, xws li kub cev lossis mob caj pas. Kev siv cov carbamazepine yuav tsum tsis ua mus ntxiv thaum pom cov kev cuam tshuam ntawm lub cev pob txha muaj nuj nqi tshwm sim.

Qee lub sijhawm lossis ntau zaus muaj qee qhov txo qis ib ntus lossis qis dua ntawm cov platelets lossis leukocytes hauv kev sib txuas nrog kev noj cov carbamazepine. Txawm li cas los xij, rau feem ntau ntawm cov xwm txheej no, lawv lub cev sab nraud tau lees paub thiab lawv tsis qhia qhov kev txhim kho ntawm mob ntshav tsis txaus lossis agranulocytosis. Ua ntej pib txoj kev kho mob thiab ntu thaum nws ua, yuav tsum tau kuaj ntshav, nrog rau kev txiav txim siab ntawm lub platelet suav (zoo li, muaj peev xwm, tus naj npawb ntawm reticulocytes thiab theem ntawm hemoglobin).

Cov tshuaj tiv thaiv mob dermatological hnyav. Cov mob ua rau mob ua paug, nrog rau cov tshuaj lom neeg mob ua paug (TEN) lossis Lyell's syndrome, Stevens-Johnson syndrome (SJS), muaj tsawg heev nrog carbamazepine. Cov neeg mob uas ua rau muaj mob txaus ntshai yuav tsum tau mus pw hauv tsev kho mob, vim tias cov xwm txheej no tuaj yeem tsim kev phom sij tau thiab ua rau muaj neeg tuag taus. Feem ntau ntawm tus mob SJS / TEN tau tshwm sim hauv thawj ob peb lub hlis ntawm kev kho nrog carbamazepine. Nrog rau kev txhim kho ntawm cov paib thiab cov tsos mob uas qhia txog kev muaj peev xwm mob dermatological zoo heev (SJS, Lyell's syndrome / TEN), carbamazepine yuav tsum tau txiav tawm tam sim ntawd thiab lwm txoj kev kho yuav tsum raug kho.

Cov Tshuaj Pharmacogenomics. Muaj cov pov thawj nce ntawm cov txiaj ntsig ntawm ntau HLA cov pa ntawm tus neeg mob lub cev rau kev phiv tshuaj tiv thaiv kab mob.

Kev Sib Txuas Lus nrog (HLA) -B * 1502. Kev tshawb nrhiav yav dhau los hauv cov neeg mob Suav ntawm cov haiv neeg Khan tau qhia tseeb txog kev sib raug zoo ntawm daim tawv nqaij ntawm SJS / TEN cuam tshuam nrog carbamazepine thiab muaj cov neeg mob leukocyte antigen (HLA), allele (HLA) -B * 1502 hauv cov neeg mob no. Kev tshaj xov xwm siab ntawm kev nthuav dav ntawm SJS (ntau tsis tshua muaj tsawg) yog tus yam ntxwv ntawm qee lub tebchaws hauv Asia (piv txwv li, cov Islands tuaj ntawm Taiwan, Malaysia thiab Philippines), qhov twg allele (HLA) -B * 1502 muaj yeej hauv cov pej xeem. Tus naj npawb ntawm cov neeg nqa khoom ntawm no allele ntawm cov pej xeem ntawm Asia yog> 15% hauv Philippines, hauv Thaib, Hong Kong thiab Malaysia, ≈10% - ntawm Fr. Taiwan, yuav luag 4% - nyob rau Suav Teb Qaum Teb, ≈2-4% - nyob rau sab qab teb Asia (suav nrog Is Nrias teb) thiab daim ntawv noj tshuaj: & nbsp ntsiav tshuaj Cov ntsiab lus:

1 ntsiav tshuaj muaj:

cov tshuaj heev : carbamazepine 200 mg lossis 400 mg,

tus zam : ethyl acrylate, methyl methacrylate thiab trimethylammonioethyl methacrylate copolymer (Eudragit ® RS 30 D), triacetin, talc, methacrylic acid thiab ethyl acrylate copolymer (Eudragit ® L 30 D-55), microcrystalline cellulose, rospovide.

Pab txhawb-tso ntsiav tshuaj 200 mg:

400 mg pab txhawb nqa cov ntsiav tshuaj: los ntawm dawb mus rau dawb nrog lub xim daj daj, sib npaug tiaj tiaj ntsiav tshuaj nrog beveled npoo, nrog cov kab uas muaj kab hla ntawm ob sab thiab 4 nqis rau sab.

Cov tshuaj kho mob pab pawg: tus neeg sawv cev tiv thaiv kab mob ATX: & nbsp

Pharmacodynamics: Ib qho tshuaj tiv thaiv antiepileptic (dibenzazepine derivative), uas tseem muaj cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kev puas hlwb thiab antidiuretic, muaj cov nyhuv analgesic rau cov neeg mob neuralgia. Lub tshuab ntawm kev ua yog txuam nrog qhov thaiv ntawm voltage-gated sodium channels, uas ua kom muaj kev nyob ruaj khov ntawm daim nyias nyias ntawm overexcited neurons, inhibition ntawm cov tsos ntawm cov feem ntawm kev puas tsuaj ntawm neurons thiab txo qis hauv synaptic impulse conduction. Tiv thaiv qhov rov tsim ntawm Na + -cov kev txiav txim siab lub peev xwm nyob rau hauv depolarized neurons. Txo kev tso tawm ntawm qhov tsis txaus siab neurotransmitter amino acid glutamate, nce qhov txo qis ntawm kev cuam tshuam ntawm lub hauv nruab nrab cov hlab ntsha txhaws thiab, yog li, txo qhov kev pheej hmoo ntawm kev qaug dab peg. Nws nce K + kev coj ua, hloov kho voltage-gated Ca 2+ channels, uas tseem tuaj yeem pab txhawb cov nyhuv anticonvulsant ntawm cov tshuaj.

Nws yog qhov zoo rau focal (ib nrab) qaug dab peg (yooj yim thiab txoj), nrog los yog tsis nrog los ntawm kev muaj feem thib ob, rau cov tonic-clonic qaug dab peg, thiab tseem rau kev sib txuas ntawm cov hom mob chua leeg (feem ntau tsis muaj txiaj ntsig rau me me qaug dab peg - tso quav mal, tsis tuaj thiab myoclonic qaug dab peg) )

Cov neeg mob qaug dab peg (tshwj xeeb tshaj yog rau cov menyuam yaus thiab cov hluas) muaj cov txiaj ntsig zoo ntawm cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab, nrog rau kev txo qis ntawm kev txob taus thiab kev txhoj puab heev.

Qhov cuam tshuam ntawm kev txawj ntse ua haujlwm thiab psychomotor kev ua tau zoo yog koob tshuaj. Qhov pib ntawm cov nyhuv anticonvulsant sib txawv los ntawm ob peb teev mus rau ntau hnub (qee lub sijhawm txog li 1 hlis vim kev pib-pib ntawm cov metabolism).

Nrog rau qhov tseem ceeb thiab theem siab trigeminal neuralgia feem ntau nws txwv tsis pub muaj qhov tsos ntawm qhov mob tawm tsam.

Kev mob nyem hauv trigeminal neuralgia tau sau tseg tom qab 8-72 teev.

Nrog rau kev tshem tawm cov cawv cawv, nws nce qib pib rau qhov tsim nyog nyeem, uas feem ntau txo qis hauv qhov mob no, thiab txo qhov mob tsis zoo ntawm cov chaw kuaj mob tshwm sim ntawm tus mob (nce ntxiv kev chim siab, tshee, gait tsis meej).

Antipsychotic (antimaniacal) kev ua tom qab 7-10 hnub, tuaj yeem yog vim yog inhibition ntawm cov metabolism hauv dopamine thiab norepinephrine.

Daim ntawv teev cov tshuaj ntau dua ua rau muaj kev saib xyuas ntawm lub zog ruaj khov dua cov carbamazepine hauv cov ntshav thaum noj 1-2 zaug hauv ib hnub.

Kev nqus tau qeeb tab sis ua tiav (kev noj mov tsis cuam tshuam loj npaum li cas thiab qhov nqus tau npaum li cas). Tom qab siv ib zaug ntawm lub ntsiav tshuaj, qhov siab tshaj plaws yog nce mus txog tom qab 32 teev. Qhov nruab nrab tus nqi ntawm qhov siab tshaj plaws ntawm cov khoom tsis hloov pauv tom qab siv ib zaug ntawm 400 mg ntawm carbamazepine yog li 2.5 μg / ml. Kev muaj zog sib luag ntawm cov tshuaj hauv plasma tau tiav tom qab 1-2 lub lis piam (tus nqi ntawm kev ua tiav yog nyob ntawm tus neeg cov yam ntxwv ntawm cov metabolism: nws pib-induction ntawm cov kab mob enzyme ntawm daim siab, hetero-induction los ntawm lwm cov tshuaj siv ua ke), zoo li ntawm tus neeg mob tus mob, noj tshuaj thiab lub sijhawm kho. Cov neeg tseem ceeb qhov sib txawv ntawm qhov muaj nuj nqis sib luag ntawm cov kev kho kom zoo yog pom: hauv cov neeg mob feem ntau, cov nqi no nyob ntawm 4 txog 12 μg / ml (17-50 μmol / l). Qhov ntau ntawm carbamazepine-10,11-epoxide (pharmacologically active metabolite) yog kwv yees li 30% ntawm kev mloog zoo ntawm carbamazepine. Kev sib txuas lus nrog ntshav protein nyob hauv menyuam yaus - 55-59%, rau cov neeg laus - 70-80%. Cov pom pom tseeb ntawm kev faib tawm yog 0.8-1.9 l / kg. Kev nqus yog tsim nyob rau hauv cerebrospinal kua thiab qaub ncaug, uas yog sib npaug rau cov nyiaj ntawm cov tshuaj nquag tsis txuam nrog cov protein (20-30%). Cais tau los ntawm qhov tsis muaj teeb meem. Kev sib xyaw hauv cov kua mis yog 25-60% ntawm qhov ntawd hauv ntshav.

Nws yog cov tshuaj tiv thaiv hauv lub siab, feem ntau nyob ntawm txoj kab kev epoxy nrog kev tsim cov metabolites lub ntsiab: nquag carbamazepine-10,11-epoxide thiab lub zog tsis ua ke nrog glucuronic acid. Lub ntsiab isoenzyme uas muab cov biotransformation ntawm carbamazepine rau carbamazepine-10,11-epoxide yog cytochrome P450 (CYP3A4). Raws li qhov tshwm sim ntawm cov teeb meem no, cov metabolite ntawm 9-hydroxymethyl-10-carbamoylacridane kuj tseem tsim, uas muaj cov haujlwm tsis muaj zog pharmacological. tuaj yeem ntxias nws cov metabolism.

Ib nrab-lub neej tom qab noj ib koob tshuaj yog 60-100 teev (thaj tsam li ntawm 70 teev), nrog kev siv lub sijhawm ntev, lub neej ib nrab raug txo vim nws pib ua haujlwm rau lub siab ua haujlwm rau lub siab ua haujlwm. Tom qab ib qho kev noj tshuaj hauv qhov ncauj ntawm carbamazepine, 72% ntawm qhov kev noj tshuaj yog tawm hauv cov zis thiab 28% nrog quav, thaum kwv yees li 2% ntawm cov tshuaj noj tau tawm hauv cov zis ua cov tsis hloov pauv carbamazepine, thiab kwv yees li 1% ntawm kev tsim 10.11-epoxy metabolite.

Tsis muaj pov thawj dab tsi qhia tau hais tias cov khw muag tshuaj ntawm carbamazepine hloov pauv ntawm cov neeg laus.

Epilepsy: thawj qhov feem ntawm qaug dab peg (tshwj tsis yog qhov tsis tuaj), cov ntawv mob ib nrab ntawm tus mob vwm (qaug dab peg thiab yooj yim), chua leeg

Mob hlwb neuralgia,

Idiopathic glossopharyngeal neuralgia,

Kev mob nrog peripheral hlab ntsha puas tsuaj hauv ntshav qab zib mellitus, mob hauv cov leeg ntshav qab zib,

Epileptiform qhov mob huam nrog ntau yam sclerosis, lub ntsej muag txhawm nrog nrog trigeminal neuralgia, ua kom mob lub cev, kev hais lus thiab lub cev tsis meej (paroxysmal dysarthria thiab ataxia), paroxysmal paresthesias thiab bouts ntawm mob,

Cawv tus neeg mob haus dej haus cawv (ntxhov siab vim yog qaug dab peg, tsis txaus siab, pw tsaug zog),

Kev puas siab puas ntsws (muaj kev cuam tshuam thiab schizoaffective cuam tshuam, psychoses, tsis meej ntawm lub limbic system).

Hypersensitivity rau carbamazepine thiab lwm yam tshuaj, thiab ntxiv rau tricyclic antidepressants,

Kev mob tsis zoo ntawm cov hlwb pob txha hematopoiesis (mob ntshav qab zib, mob leukopenia),

Mob sib quas ntus porphyria (suav nrog keeb kwm)

Ib txhij tswj hwm ntawm lithium npaj thiab MAO inhibitors.

Decompensated mob plawv tsis ua hauj lwm,

Kev ua haujlwm rau lub cev hyponatremia (ADH kev mob siab tsis haum, hypopituitarism, hypothyroidism, adrenal cortex tsis txaus),

Qhov ua rau lub siab thiab lub raum tsis ua haujlwm,

Kev nquag haus cawv (CNS kev nyuaj siab zuj zus, carbamazepine metabolism ua rau hnyav),

Kev txwv tsis pub cov pob txha mob hematopoiesis nrog kev siv tshuaj (keeb kwm),

Kev mob ntshav siab

Ua rau muaj kev cia siab rau lub cev,

Hauv kev sib xyaw nrog sedative-hypnotics.

Cev xeeb tub thiab lactation:

Thaum twg los xij tau, Finlepsin® retard raug tso cai rau cov poj niam kev muaj me nyuam hauv lub hnub nyoog ntawm kev kho mob hlwb, hauv kev siv tshuaj tsawg kawg nkaus, txij li thaum lub sijhawm ua haujlwm tsis zoo ntawm cov me nyuam yug los ntawm cov niam uas tau noj tshuaj tiv thaiv kev kho mob siab dua nrog kev kho mob monotherapy.

Thaum cev xeeb tub tshwm sim, nws yog ib qho tsim nyog los sib piv cov txiaj ntsig ntawm kev kho thiab qhov muaj peev xwm ua tau tshwm sim, tshwj xeeb tshaj yog nyob rau thawj peb lub hlis thaum cev xeeb tub.Nws raug paub tias cov menyuam yaus ntawm leej niam uas muaj kev txom nyem los ntawm kev mob vwm tuaj yog thawj coj rau txoj kev loj hlob ntawm intrauterine, suav nrog kev ua tsis tiav. Finlepsin® retard muaj peev xwm ua kom muaj kev pheej hmoo ntawm cov teeb meem no. Muaj cov ntaub ntawv sib cais los ntawm tus neeg mob ntawm cov kab mob ua tsis taus pa thiab tsis zoo, suav nrog kev tsis kaw cov pob txha caj qaum (spina bifida).

Cov tshuaj antiepileptic nce folic acid deficiency, uas feem ntau pom thaum cev xeeb tub, uas tuaj yeem ua rau muaj qhov tsis zoo ntawm kev yug menyuam hauv menyuam yaus, yog li noj folic acid pom zoo ua ntej npaj lub sijhawm cev xeeb tub thiab thaum cev xeeb tub. Txhawm rau tiv thaiv hemorrhagic muaj teeb meem hauv cov menyuam tshiab, cov poj niam nyob hauv lub lis piam kawg ntawm cev xeeb tub, nrog rau cov menyuam yug tshiab, raug nquahu kom xa tshuaj vitamin K1.

Carbamazepine hla mus rau niam mis, yog li cov txiaj ntsig thiab qhov tsis xav tau ntawm kev pub niam mis yuav tsum muab piv nrog kev kho mob txuas ntxiv. Nrog kev pub mis niam txuas ntxiv thaum noj cov tshuaj, koj yuav tsum tsim kev soj ntsuam rau tus menyuam hauv kev txuas nrog qhov muaj feem ua rau muaj kev phiv tshuaj (piv txwv li, nkees nkees heev, ua xua ntawm daim tawv)

Muab thiab kev coj:

Sab hauv, thaum lossis tom qab noj mov, haus dej kom ntau.

Rau kev yooj yim ntawm kev siv, lub ntsiav tshuaj (nrog rau nws ib nrab lossis plaub hlis) tuaj yeem yaj ua ntej hauv dej lossis hauv kua txiv, txij li cov cuab yeej ntawm lub sijhawm ntev tso tawm ntawm cov tshuaj nquag tom qab yaj lub ntsiav tshuaj hauv cov kua yog khaws cia. Qhov ntau ntawm cov koob tshuaj siv yog 400-1200 mg rau ib hnub, uas faib tawm hauv 1-2 zaug ib hnub.

Qhov siab tshaj plaws txhua hnub noj yuav tsum tsis pub tshaj 1600 mg.

Thaum twg los xij tau, Finlepsin® retard yuav tsum yog kws kho mob tshuaj tua kab mob. Kev kho mob pib nrog kev siv tshuaj rau ib qho me me txhua hnub, uas tom qab ntawd maj mam nce ntxiv kom txog thaum pom qhov txiaj ntsig zoo tshaj plaws. Qhov sib ntxiv ntawm Finlepsin® retard rau kev kho cov tshuaj tiv thaiv kev ua haujlwm tsis tu ncua yuav tsum tau nqa tawm maj, thaum cov koob tshuaj ntawm cov tshuaj siv tsis hloov pauv lossis, yog tias tsim nyog, kho. Yog tias tus neeg mob tau hnov ​​qab noj cov tshuaj txuas ntxiv ntawm lub sijhawm, lub sijhawm noj tshuaj ploj yuav tsum tau noj sai li sai tau thaum qhov kev zam no tau pom, thiab koj yuav tsum tsis txhob noj ob npaug ntawm cov tshuaj.

Qhov tshuaj thawj zaug yog 200-400 mg ib hnub, tom qab ntawd cov koob tshuaj tau maj mam nce mus txog thaum pom cov txiaj ntsig zoo tshaj plaws. Qhov kev saib xyuas txij nkawm yog 800-1200 mg rau ib hnub, uas tau muab faib ua 1-2 koob tshuaj ib hnub.

Thawj koob tshuaj rau cov menyuam muaj hnub nyoog li ntawm 6 txog 15 xyoos yog 200 mg ib hnub twg, tom qab ntawd cov koob tshuaj no maj mam nce los ntawm 100 mg rau ib hnub txog thaum pom qhov ua haujlwm zoo tshaj plaws.

Kev ntsuas rau siv

Finlepsin pom zoo rau ntau tus kabmob suav nrog:

• neuralgia
• qaug dab peg
• ntau yam mob cuam tshuam
• kev xav hauv lub siab
• haus dej cawv

Tus kws kho mob ua rau muaj kev teem sijhawm rau txhua tus neeg raws li cov lus qhia thiab kev kuaj mob. Kev tswj hwm tus kheej ntawm cov tshuaj yog categorically tsis pom zoo.

Cov Yuav Tsum Muaj

Finlepsin tsis pom zoo rau:

• ib leeg tsis quav ntsej rau ib qho ntawm cov khoom siv lossis rau toidepressants (tricyclic)
• concomitant siv MAO inhibitors lossis lithium npaj
• kev cuam tshuam ntawm cov hlwb pob txha hematopoiesis
• AV thaiv
• mob siab rau plooj (porphyria)

Nrog huab ceev faj, ntsiav tshuaj yog tshuaj rau:

• nrog kev ua txhaum ntawm ob lub raum, mob siab, kab mob plawv
• cov neeg laus laus
• siv cov tshuaj tsis tsaug zog los yog siv cov tshuaj tsaug zog
• nce siab (intracranial, intraocular)
• prostate kab mob
• haus cawv ntev zuj zus

Sab nyhuv ntawm daim ntawv thov Finlepsin tuaj yeem muab cov kev ua txhaum cov lus qhia rau siv, piv txwv li, siv ntau tshaj. Hauv cov kev hloov pauv no, muaj kev ntxhov siab hauv kev ua haujlwm ntawm cov hlab ntsha hlwb thiab endocrine, zoo li hauv cov hematopoietic system, tuaj yeem sau tseg. Ua tsis tiav cov lus qhia hauv cov lus qhia no tuaj yeem ua rau tsis tsuas yog kev cuam tshuam ib ntus hauv daim ntawv ntawm mob taub hau lossis xeev siab, tab sis kuj tseem muaj kev cuam tshuam loj dua: mob leukocytosis, mob leukopenia, thiab lwm yam.

Finlepsin muaj cov ntsiab lus carbamazepine (cov tshuaj tseem ceeb) thiab cov khoom siv pabcuam: magnesium stearate, gelatin, croscarmellose sodium, MCC, etc. Daim ntawv tso tawm ntawm cov tshuaj yog ntsiav tshuaj. Cov tshuaj raug pom zoo kom noj tsuas yog raws li kws kho mob tau sau tseg thiab ua raws nkaus li cov lus qhia.

Finlepsin ntsiav tshuaj: cov lus qhia rau kev siv

Finlepsin ntsiav tshuaj raws li cov lus qhia rau kev siv yog npaj rau kev tswj hwm ntawm qhov ncauj, tsis tas yuav hais txog cov khoom noj. Ua raws li qhov mob hnyav ntawm cov kev mob lossis kab mob thiab cov duab kho mob dav dav, cov neeg laus yuav tau raug txiav txim siab yam tsawg kawg 200 mg (1 ntsiav tshuaj, kev kho mob thaum xub thawj), kev kho kev saib xyuas suav nrog kev siv tshuaj ntawm qhov ntau npaum 800-1200 mg ib hnub (muab faib ua ob peb zaug). Qhov siab tshaj plaws tau tso cai ntau npaum li cas yog 1.2-2 g. Ua ntej thaum kawg ntawm kev kawm, qhov ntau ntawm cov tshuaj yog txo qis. Raws li cov lus qhia, kev ua txhaum cai ntawm kev pub nkag tuaj yeem ua rau muaj kev tsis zoo. Cov menyuam yaus, ntawm lub hauv paus ntawm kev taw qhia, pom zoo kom pib noj nrog cov tshuaj "Finlepsin Retard "nyob rau hauv qhov ntau npaum ntawm 200 mg (analogue).

Nrog neuralgia Kuv tuaj yeem coj?

Finlepsin pab nrog trigeminal neuralgia, tab sis qee tus neeg mob tau tawm tswv yim tias qhov no coj mus rau qhov tsis nco qab, uas ua rau muaj kev poob qis hauv kev sib txuas lus. Nyob rau hauv txhua rooj plaub, lub sijhawm teem los ntawm tus kws tshaj lij, yog li ntawd, yog tias tsis xav tau (phiv) tshwm sim, koj yuav tsum tsis txhob noj tshuaj thiab sab laj nrog koj tus kws kho mob dua.

Nrog cev xeeb tub thiab menyuam tuaj yeem?

Thaum cev xeeb tub, cov poj niam tau raug xaj, yog tias ua tau, tshuaj kho mob tsawg kawg hauv kev noj tshuaj (kho nrog ib hom tshuaj). Qhov no txo ​​txoj kev pheej hmoo ntawm kev mob plab yug me nyuam hauv plab. Kev teem sij hawm ntawm kev nkag mus kawm chav kawm yog txiav txim siab los ntawm tus kws kho mob nkaus xwb, nyob ntawm qhov ntsuas ntawm tus neeg mob. Cov lus qhia zoo ib yam, raws li cov lus qhia rau kev siv, kuj qhia nyob rau lub sijhawm lactation.

Kws kho mob pom zoo rau cov menyuam yaus Finlepsin Retard (analogue) hauv cov ntsiav tshuaj ntawm qhov ntau npaum ntawm 200 mg:

• 1-5 xyoos - ntau kawg noj ntau yog 400 mg ib hnub twg (pib noj, maj mam nce qhov koob ntawm 200 mus rau qhov qhia 400 mg)
• 6-10 - qhov siab tshaj plaws ib hnub twg ntawm 600mg
• 11-15 xyoo - tuaj yeem tso cai txhua hnub ntau tshaj 1000 mg

Finlepsin Retard

Raws li cov lus qhia rau kev siv Finlepsin Lawv pib noj cov retard kom zoo, maj mam nce lub koob. Dosage nyob ntawm qhov ntsuas: qhov mob hnyav, daim ntawv ntawm qhov tsos, hnub nyoog thiab cov yam ntxwv ntawm lub cev. Hauv qee kis, nws pom zoo hloov pauv Finlepsin Rov qab mus rau cov kab ke, tab sis, tsuas yog tus kws kho mob tuaj yeem txiav txim siab tau.

Finlepsin thiab dej cawv sib xws?

Nws yog pov thawj tias lub ntsiab ua haujlwm tseem ceeb ntawm cov tshuaj txo cov nyhuv ntawm ethanol. Txawm li cas los xij, raws li cov lus qhia rau kev siv, nws tsis pom zoo kom sib xyaw ntsiav tshuaj nrog kev siv cov dej cawv - kev hem thawj ntawm kev phiv thiab txawm tias muaj teeb meem loj ntxiv.

Cov piv txwv zoo ntawm cov tshuaj Finlepsin (ntsiav tshuaj):

• Carbalepsin Retard (INN)
• Zeptol
• Acterval
• Tegretol
• Zagretol
• Dab neeg

Tsuas yog tus kws kho mob uas tuaj koom thiaj tuaj yeem sau cov cim thiab sau ib daim qauv tshuaj rau qhov siv. Raws li cov lus qhia rau kev siv, kev tswj hwm tus kheej yog nruj me ntsis tsis pom zoo.

Lub tsev muag tshuaj raug nqi li cas?

Cov tshuaj yog ib qho tshuaj thiab tau faib tshwj xeeb rau cov tshuaj. Tus nqi ntawm cov tshuaj nws txawv nyob rau hauv thaj tsam ntawm 200-280 rubles (nyob ntawm seb qhov ntau npaum thiab tshuaj ntawm lub tsev muag tshuaj).

Kev ntsuas rau siv Finlepsin loj heev. Cov kws tshaj lij nco txog nws txoj kev ua haujlwm siab hauv kev kho mob ntawm ntau yam mob thiab kab mob nrog kev ua raws li cov lus qhia, ua pov thawj los ntawm lawv cov kev soj ntsuam zoo.

Kev tshuaj xyuas tus neeg mob yog ib qho zoo ib yam li cov lus xaus ntawm cov kws kho mob, tab sis ntxiv rau qhov ua tau zoo, qhov cuam tshuam xws li kev ua haujlwm ntawm kev txawj ntse poob qis, kev tsis zoo ntawm lub cev tsis zoo, thiab lwm yam tau sau tseg.

Finlepsin Yam ntxwv

Cov chaw tsim tshuaj lag luam muab tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj muaj 200 mg ntawm carbamazepine ua cov khoom xyaw dhia. Qhov tshuaj yeeb dej caw no muaj qhov cuam tshuam rau lub hlwb hlwb, inhibiting qhov tshwm sim ntawm cov hlab ntsha cuam tshuam. Vim qhov no, Finlepsin muab cov kev kho mob hauv qab no:

• anticonvulsant, suav nrog nrog qaug dab peg,
• anti-manic, txo kev ntxhov siab, txob taus, tshwm sim ntawm kev nyuaj siab,
• Kev ua kom loog rau mob ntawm ntau cov kab ke ntawm cov hlab ntsha tawg, piv txwv li nrog neuritis.

Cov tshuaj tseem yog tau sau tseg rau qhov tau npaj txhij los ntawm tus mob thim rov qab, uas tshwm sim los ntawm kev haus cawv ntev.

Finlepsin yog qhia rau cov kab mob hauv qab no:

• qaug dab peg, suav nrog nws cov ntawv sib xyaw,
• mob vwm epileptiform uas tshwm sim nrog ntau yam mob sclerosis, paresthesia, diazartria thiab lwm yam kab mob kev nkeeg,
• mob nrog neuritis thiab kev puas tsuaj rau lub paj hlwb peripheral, suav nrog ua rau mob ntshav qab zib,
• neuralgia ntawm tsis paub keeb kwm,
• kev puas siab puas ntsws, nrog rau cov mob los ntawm kev nkag rau lub cev,
• raws li ib feem ntawm kev kho kom zoo ntawm cov tsos mob tshem tawm.

Cov tshuaj muaj tshuaj ntau yam tsis sib haum, yog li koj tuaj yeem siv nws yam tsis tas muaj kws kho mob sau. Ntawm cov kev mob hauv lub cev uas nws tsis pom zoo kom siv Finlepsin yog hematopoiesis, atrioventricular block, porphyria, thiab tus neeg tsis qaug rau cov tshuaj ntawm cov tshuaj.

Tawm tsam keeb kwm ntawm kev kho mob nrog Finlepsin, kev txhim kho ntawm kev tsis zoo los ntawm kev zom zaub mov hauv lub cev, hlab ntsha, hlab plawv, endocrine, cov kab mob genitourinary, cov leeg ua haujlwm, cov leeg lub siab thiab cov ntshav tsim tau. Daim ntawv teev cov kev mob tshwm sim tau ntev. Yog tias muaj cov tsos mob tsis zoo tshwm sim, tsum tsis txhob noj cov ntsiav tshuaj thiab sab laj nrog kws kho mob.

Finlepsin tsis pom zoo yog tias muaj kev ua txhaum ntawm kev tsim cov ntshav, atrioventricular block, porphyria, tus neeg tsis qaug rau cov tshuaj ntawm cov tshuaj.

Kev Sib piv Cov Tshuaj

Cov tshuaj kho mob zoo sib xws hauv feem ntau, tab sis muaj qee yam sib txawv.

Cov kev npaj tau muaj tib yam kev ua ub ua no, muaj tib yam qhia rau siv. Lawv tsis pom zoo rau kev siv nrog tib lub cev kev ua haujlwm thiab pathological ntawm lub cev. Muaj kev phiv los sis noj tshuaj kuj zoo ib yam.

Cov tshuaj kho mob yog tsim los ntawm ib lub chaw tsim khoom lag luam - tuam txhab transatlantic Teva. Ob yam tshuaj no muaj nyob rau hauv hwj tshuaj.

Dab tsi yog qhov txawv?

Finlepsin retard sib txawv ntawm nws tus thawj ntawm hauv kev ua haujlwm ntev. Ib zaug nyob rau hauv lub cev, nws cov khoom siv tau tso tawm maj, vim tias qhov concentration ntawm cov tshuaj yog tswj nyob rau lub sijhawm ntev dua. Qhov no cuam tshuam phiv - txoj kev pheej hmoo ntawm lawv tshwm sim txo qis.

Finlepsin retard ua rau muaj ntau qhov phiv, suav nrog xeev siab, ntuav, tsaug zog, tsis meej pem, thiab teeb meem tsis pom kev.

Kev Ntsuam Xyuas Rau Neeg Mob

Marina, 27 xyoo, Ryazan: “Kuv yuav tsum tau ntsib Finlepsin thaum kuv tus yawm txiv tau qaug dab peg. Nws tsis yog epileptic, tab sis zoo li xws li. Tus kws kho mob tau sau cov tshuaj no, hais tias nws tsuas yog siv tsis yog los ntawm cov neeg mob vwm, tab sis kuj yog cov neeg muaj kev mob siab. Tus txiv dev no pib noj tshuaj, tab sis pib yws yws tas li ntawm kiv taub hau thiab xeev siab. Kuv yuav tsum tau rov qab mus rau tus kws kho mob uas kho Finlepsin retard. Txiv zam rau cov tshuaj nuav zoo. ”

Irina, 41 xyoo, Voronezh: “Finlepsin tau raug samfwm rau nws tus txiv tom qab mob hlab ntsha tawg. Tus txij nkawm noj tshuaj rau lub hlis thib ob. Nws tsis yws txog cov kev phiv. Tus txij nkawm zoo mloog ntau, tus kws kho mob lees tias cov kev kho mob pom tias zoo. "

Cov kws kho mob tshuaj xyuas Finlepsin thiab Finlepsin retard

Igor, kws kho mob, hnub nyoog 45 xyoos, Nizhny Novgorod: “Ob yam tshuaj ua tau zoo heev, kev tiv thaiv zoo los ntawm cov neeg mob. Tus nqi pheej yig. "

Vladimir, kws kho mob hlwb, 51 xyoo, Bryansk: “Nyob ntawm tus kab mob thiab lub xeev ntawm kev noj qab haus huv ntawm tus neeg mob, kuv sau ntawv rau Finlepsin lossis qhov piv txwv ntawm kev ua ntev. Kuv ntseeg tias ob yam tshuaj no muaj txiaj ntsig zoo. Cov kev mob tshwm sim yog, tab sis tsis tshua muaj, yog tias tus neeg mob ua raws li cov lus qhia khomob. Ib qho ntxiv yog tus nqi tshuaj: nws muaj rau yuav luag txhua tus neeg. "