Cov tshuaj Onglisa los ntawm ntshav qab zib mellitus - cov lus qhia ntxaws ntxiv rau kev siv

Tus kab mob no cuam tshuam txog 9% ntawm cov neeg hauv ntiaj teb. Cov chaw lag luam kws tshuaj thiab kev kho mob ntawm cov thawj coj hauv ntiaj teb tau nqis peev nyiaj ntau lab daus las, thiab cov ntshav qab zib tau sib kis ib puag ncig ntawm lub ntiaj teb, ua rau cov yau dua, ua rau muaj kev tawm tsam ntau.

Kev mob kis tau rau ntawm lub teev uas tsis tau xav tias: los txog rau xyoo 2020, ib nrab lab tus neeg mob uas muaj ntshav qab zib hom 2 tau kwv yees hais, thiab cov kws kho mob tsis tau kawm paub tswj hwm tus kabmob no tau li cas

Yog tias muaj ntshav qab zib hom 1, uas cuam tshuam tsawg dua 10% ntawm txhua tus neeg mob ntshav qab zib, txhua yam yog yooj yim: txo qhov hnoos ntshav qabzib hauv cov ntshav los ntawm kev txhaj tshuaj insulin (tsis muaj dab tsi ntxiv tuaj yeem muaj nyob ntawd) thiab txhua yam yuav zoo (hnub no, rau cov neeg mob no, lawv kuj tau tsim cov qog cuav) ), tom qab ntawd nrog hom ntshav qab zib hom 2, thev naus laus zis siab tsis ua haujlwm.

Los ntawm cov piv txwv, rau hom ntshav qab zib hom 2, piam thaj tau tshaj tawm tias yog tus yeeb ncuab tseem ceeb, txhawm rau ua lag luam nrog cov tshuaj txo cov ntshav qab zibCov. Kev kho mob ntshav qab zib nrog kev pab los ntawm kev ua kom zoo pyramids yog qhov muaj zog, thaum lwm cov tshuaj tau siv rau ib qho tshuaj, tom qab ntawv thib peb cov tshuaj ntxiv rau hauv cov txheej txheem no kom txog thaum tig los ntawm insulin.

Tau 20 lub xyoo dhau los, cov kws kho mob tau tawm tsam nrog kev noj qab zib, tab sis cov txiaj ntsig yog qis dua xoom, vim tias cov kev mob tshwm sim thiab cov teeb meem los ntawm cov tshuaj feem ntau tshaj lawv cov hauj lwm zoo, tshwj xeeb yog tias koj tsis ua raws li txoj kev noj tshuaj, tsis txhob suav nrog leej twg cov tshuaj uas haum rau thiab leej twg tsis ua.

Ib ntawm cov phiajcim kabmob no yog lub plawv thiab cov hlab ntshav. Nws yog qhov tseeb hais tias kev kho mob ntshav qab zib ntau dhau ua rau lub txiaj ntsig thiab ua rau vascular tuag. Qab Zib tsuas yog cov cim ntawm hom ntshav qab zib hom 2 xwb; tus kab mob yog ua raws li mob metabolic.

Cov tshuaj ntawm cov cim tshiab Onglisa, tsim los ntawm cov kws tshawb fawb British thiab Italian, tsis tsuas yog muaj tshuaj tua kab mob, tab sis kuj muaj peev xwm tiv thaiv cardioprotective. Cov tshuaj ntawm cov incretin koob, uas suav nrog Onglisa, yog qhov kev hloov kho tshiab tshaj plaws hauv thaj chaw ntawm kev mob ntshav qab zib. Lawv ua haujlwm kom txo tau qab los noj mov thiab kom poob ceeb thawj - ib qho ntawm cov laj thawj tseem ceeb ntawm kev txhim kho mob ntshav qab zib hom 2.

Tsis tas li ntawd, ntau ntxiv rau cov ntsiab lus tsis yog ua rau kom cov ntshav qog ntshav qab zib, pab txo ntshav siab, thiab tiv thaiv kab mob pancreatic. Tus nqi siab thiab tsis muaj kev soj ntsuam mob vim lub sijhawm luv luv ntawm kev siv tshuaj tuaj yeem raug ntaus nqi rau qhov tsis zoo ntawm Onglisa, tab sis qhov no tseem yog lub sijhawm.

Kev Sib Sau thiab daim ntawv ntawm tso tawm

Txhua ntsiav tshuaj Onglisa, cov duab uas tau nthuav tawm hauv ntu no, muaj 2.5 lossis 5 mg ntawm saxagliptin hydrochloride hauv lub plhaub. Cov mis tau ntxiv nrog cov kev zam: cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate thiab Opadray dyes (dawb, daj thiab xiav rau 2.5 mg ntsiav tshuaj thiab dawb, liab thiab xiav rau ntau npaum li 5 mg).

Cov tshuaj tuaj yeem tuaj yeem paub tau los ntawm cov duab (cov ntsiav tshuaj biconvex nrog lub ntsej muag daj thiab kos cim 2.5 / 4214 thiab pinkish nrog engraving 5/4215). Cov ntawv luam yuav tau ntaus thwj rau ntawm ib sab nrog tus cwj mem xiav.

Koj tuaj yeem yuav cov tshuaj uas kws kho mob xaj tau. Rau Ongliz ntsiav tshuaj, tus nqi tsis yog los ntawm qeb pob nyiaj siv: rau 30 pcs. 5 mg hauv Moscow koj yuav tsum them 1700 rubles. Cov neeg tsim khoom tau txiav txim siab lub neej txee ntawm cov tshuaj nyob rau hauv 3 xyoos. Cia rau cov tshuaj yuav tsum txheem.

Cov yam ntxwv ntawm Pharmacological

Lub ntsiab tseem ceeb ntawm Onglisa yog saxagliptin. Hauv ib hnub tom qab nkag rau hauv txoj hnyuv, nws cuam tshuam kev ua si ntawm DPP-4 peptide. Thaum muaj kev sib cuag nrog cov piam thaj, qhov kev tshem ntawm cov enzyme hloov zuj zus (2-3 zaug) txhim kho kev zais ntawm glucagon-zoo li peptide-1 (GLP-1) thiab piam thaj-insulinotropic polypeptide (HIP).

Nyob rau tib lub sijhawm, qib ntawm glucagon hauv b-hlwb poob qis, kev ua haujlwm ntawm b-hlwb lub luag haujlwm rau kev tsim cov tshuaj endogenous insulin nce. Yog li ntawd, qhov ntsuas ntawm kev yoo mov thiab postprandial glycemia yog txo qis.

Kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj tau kawm hauv 6 qhov kev sim, hauv 4148 cov neeg ua haujlwm pab dawb uas muaj hom 2 tau koom nrog. Txhua tus neeg tuaj koom qhia pom qhov muaj nuj nqi zoo ntawm glycated hemoglobin, starvation qab zib thiab glycemia tom qab kev ua kom zoo ntawm lub cev. Cov tshuaj ntxiv, xws li thiazolidinediones, metformin, glibenclamide, tau raug tshaj tawm rau cov neeg koom nrog ib tus uas tsis ua tiav 100% glycemic tswj.

Cov neeg mob noj tshuaj ntxiv tiv thaiv kab mob tau pom zoo sib xws. Qhov hnyav ntawm txhua tus neeg tuaj koom rau hauv cov kev sim kawm tseem nyob ruaj khov.

Thaum Saxagliptin tshuaj

Tus mob ntshav qab zib nrog hom 2 Tus kab mob Ongliz tau sau tseg:

Zoo li monotherapy, ua ke nrog kev ua neej hloov kho,
Hauv kev sib xyaw, nrog ntxiv ntawm cov kev xaiv dhau los nrog metformin, yog hais tias monotherapy tsis muab kev tswj tiav ntawm glycemia,
Ua ke nrog cov peev txheej ntawm sulfanylurea series thiab thiazolidinediones, yog tias kev sib xyaw dhau los siv tsis tau txaus.

Rau leej twg Onglisa yog contraindicated

Txij li thaum saxagliptin yog qhov muaj lub zog loj uas ua rau muaj kev tiv thaiv zoo ntawm b cell thiab txwv tsis pub ua haujlwm ntawm b cell, nws tuaj yeem siv nrog qee qhov kev txwv, tshwj xeeb, cov tshuaj tsis qhia:

Cov poj niam cev xeeb tub thiab lactating leej niam
Hauv thaum yau,
Tus mob ntshav qab zib hom 1,
Nrog rau hom insulin-tiv thaiv ntshav qab zib hom 2,
Ntshav qab zib ketoacidosis
Yog hais tias tus neeg mob tsis zam galactose,
Nrog hypersensitivity rau cov khoom xyaw ntawm cov mis.

Thaum xaiv cov txheej txheem kho mob, tus kws kho mob tsom tsis tau tsuas yog nyob ntawm cov npe contraindications, tab sis kuj tseem nyob rau kev sib raug zoo nrog saxagliptin ntawm cov tshuaj uas cov ntshav qab zib siv los ntawm cov kab mob concomitant. Yog li, txhua cov tshuaj uas cov mob ntshav qab zib noj nyob rau hauv parallel, tus kws kho mob yuav tsum tau qhia kom raws sijhawm.

Kev pom zoo rau kev siv

Tus kws kho mob txiav txim qhov ntau npaum li cas ntawm cov tshuaj ib leeg zuj zus, coj mus rau hauv qhov txiaj ntsig ntawm kev tshuaj xyuas, hnub nyoog, theem ntawm tus kab mob, cov tshuaj tiv thaiv ntawm lub cev. Txog Onglisa, cov lus qhia rau kev siv pom zoo kom noj cov ntsiav tshuaj ntawm qhov ncauj, tsis tas khi rau lub sijhawm noj mov. Tus txheej txheem pib siv tshuaj yog 5 mg / hnub.

Thaum pib ntawm chav kawm ntawm kev kho, qauv txheej txheem zoo li no:

Saksagliptin - 5 mg / hnub.,
Metformin - 500 mg / hnub.

Tom qab 10-15 hnub, ntsuas kev siv tshuaj kho cov kab mob uas tau xaiv thiab, yog tias tsim nyog, kho cov koob tshuaj metformin, ua raws li tus qauv ntawm Onglisa tsis hloov pauv.

Yog tias lub sijhawm thaum noj cov tshuaj ploj, nws raug coj mus nyob rau ib lub sijhawm ib zaug thaum thawj zaug. Koj tsis tuaj yeem muab ob npaug rau qhov ua tau, vim tias lub cev xav tau sijhawm los ua nws.

Yog tias muaj keeb kwm muaj mob raum, tsis tas yuav muaj koob tshuaj feem tsawg. Nrog cov ntawv sau ua mob hnyav thiab mob hnyav, cov cai yog txo los ntawm 2 zaug - 2.5 mg / hnub. (ib-zaug).

Thaum lub caij hemodialysis, ib lub ntsiav tshuaj yuav qaug cawv ntawm tus txheej txheem tom qab. Cov nyhuv ntawm Onglisa rau cov neeg mob uas mob peritoneal lim ntshav tsis tau kawm. Ua ntej sau ntawv tshuaj thiab thoob plaws chav kawm, nws yog qhov yuav tsum tau ntsuas qee qhov kev ua haujlwm ntawm lub raum.

Nrog rau cov kab mob siab (hepatic pathologies), cov tshuaj yog tawm hauv cov tshuaj 5 mg / hnub. Rau cov ntshav qab zib ntawm lub hnub nyoog loj, tsis tas yuav tsum tau txhaj ib feem kaum, tab sis kev mob raum yuav tsum txiav txim siab.

Cov koob tshuaj ntawm incretins yog txo los ntawm ib nrab nrog txoj kev kho mob nrog inhibitors:

Atazanavir
Ketoconazole,
Igraconazole
Nelfinavir
Clarithromycin
Ritonavir
Saquinavir,
Indinavir
Telithromycin.

Tsis muaj ntaub ntawv raug cai ntawm kev paub meej ntawm kev siv tshuaj rau cov poj niam cev xeeb tub thiab menyuam yaus hnub nyoog qis dua 18 xyoo, yog li ntawd cov tshuaj analogues raug xaiv rau hom mob ntshav qab zib no.

Undesirable zoo thiab overdose

Cov tshuaj ntawm cov pab pawg incretin ntawm cov tub ntxhais tiam tam sim no yog ib qho kev nyab xeeb tshaj plaws. Nrog rau txhua qhov kev pom zoo ntawm tus kws kho mob, Ongliz muaj peev xwm zam tau txhua zaus los ntawm cov neeg mob ntshav qab zib feem ntau.

Hauv qee kis, cov hauv qab no raug sau tseg:

Dyspeptic mob
Mob taub hau
Kev mob caj dab
Kab mob sib kis
Urogenital kab mob ntawm qhov kis tau.

Yog tias ib qho ntawm cov tsos mob no lossis lwm yam kev txawv txav tsis haum, koj yuav tsum tau ncua kev siv tshuaj thiab sab laj nrog koj tus kws kho mob.

Rau cov hom phiaj kev tshawb fawb, cov tshuaj tau muab rau cov neeg tuaj yeem pab hauv cov koob tshuaj ntau dua qhov suav txog 80 zaug. Cov cim ntawm intoxication tsis tsau. Tshaj saxagliptin tuaj yeem raug tshem tawm uas siv hemodialysis.

Cov lus pom zoo ntxiv

Saxagliptin tsis raug sau cia hauv txoj cai tswjfwm peb zaug hauv kev txhaj tshuaj insulin yog ua ke nrog metformin thiab thiazolidinediones, vim tias qhov cuam tshuam ntawm kev cuam tshuam no tsis tau kawm. Kev tswj raum yog nqa tawm ntawm txhua theem ntawm kev kho mob nrog Onglisa, tab sis nrog rau daim ntawv me me, kev noj tshuaj tsis hloov, hauv lwm yam nws yog halved.

Saxagliptin nrog kev hwm txog hypoglycemic zoo muaj kev nyab xeeb kiag li, tab sis hauv kev sib xyaw nrog sulfonylurea tshuaj muaj peev xwm ua rau muaj teeb meem hypoglycemic. Yog li no, nrog txoj kev kho mob nyuaj, ib feem kaum ntawm kev txhaj tshuaj ntawm tom kawg hauv kev taw qhia ntawm qhov txo qis yog qhov yuav tsum ua.

Thaum muaj kev tsis haum rau cov tshuaj ntawm cov tshuaj incretin series - DPP-4 inhibitors, Onglisa kuj tseem tsis yog kws kho mob, txij li qee kis muaj kev tsis haum tshuaj los ntawm kev ua pob khaus tawv nqaij ua rau anaphylactic ceeb thiab angioedema, xav tau kev tshem tawm yeeb tshuaj tam sim, tau sau tseg.

Txij li thaum cov tshuaj muaj lactose, nws tsis yog kws kho mob rau cov neeg mob ntshav qab zib nrog ib tus neeg kam, lactose tsis txaus, qabzib-galactose malabsorption.

Thaum lub sijhawm kuaj xyuas tus mob ntshav qab zib tom qab kho nrog Onglisa, muaj tus mob ntawm kev loj hlob ntawm tus mob leeg qhuav. Thaum sau ntawv ib chav ntawm saxagliptin, tus neeg mob yuav tsum paub txog cov yam ntxwv ntawm tus yam ntxwv: qhov mob tas mus li thiab mob hnyav ntawm lub epigastrium.

Yog tias muaj qhov tsis xis nyob hauv plab, koj yuav tsum tsum tsis txhob noj tshuaj thiab qhia qhov mob siab rau koj tus kws kho mob. Qhov kev tshwm sim yog ib ntus thiab thim rov qab, hla lawv tus kheej tom qab tsis txiav yeeb tshuaj.

Hauv raum tsis ua hauj lwm hauv kev tsim mob hnyav thiab mob hnyav, ib qho tshuaj feem pua ib zaug. Hauv cov mob hnyav, Onglizu siv nrog ceev faj, ntawm lub davhlau ya nyob twg, thaum tus neeg mob tsis tuaj yeem tsis muaj hemodialysis, tsis txhob siv txhua lub sijhawm. Kev saib xyuas cov mob ntawm ob lub raum hauv cov xwm txheej zoo li no tau ua ua ntej pib kev pib kho thiab txhua txhua rau lub hlis nrog kev siv Ogliza tas li.

Cov kev paub hauv kev kho tus mob ntshav qab zib rau cov laus (txij li 75 xyoo) tsis txaus, yog li no, cov neeg mob no xav tau kev saib xyuas ntau ntxiv.

Cov txiaj ntsig ntawm cawv ntawm Onglisa ntawm kev muaj peev xwm tswj hwm kev thauj khoom lossis cov txheej txheem nyuaj tseem tsis tau tshaj tawm, yog li, cov neeg mob ntshav qab zib yuav tsum noj cov tshuaj nrog ceev faj, tshwj xeeb tshaj yog vim kiv taub hau tshwm sim ntawm cov kev mob tshwm sim. Kev saib xyuas tshwj xeeb hauv cov xwm txheej zoo li no yuav tsum muaj rau cov neeg mob siv Onglisa hauv kev kho mob nyuaj, vim tias qee cov tshuaj tiv thaiv kab mob tuaj yeem ua rau mob ntshav qab zib tsis txaus.

Cov kev paub ntawm kev siv cov tshuaj rau cov teeb meem plawv plawv pom tias cov tshuaj normalizes plawv. Hauv Asmeskas, txawm tias nyob rau sab sauv txwv ntawm kev thaj ua rau thaj, tus kws kho mob tau sau ntawv rau cov neeg mob ntshav qab zib nrog arrhythmia Onglizu txhawm rau txhim kho glycemic indices thiab rov qab kho lub plawv dhia.

Cov Tshuaj Yeeb Yeeb Tshuaj Tiv Thaiv nrog Onglisa thiab analogues

Raws li cov ntaub ntawv ntawm kev tshawb fawb, cov txiaj ntsig ntawm kev sib cuam tshuam ntawm Onglisa nrog rau lwm cov khoom ntxiv thaum kev kho mob tsis tseem ceeb hauv cov chaw kho mob.

Qhov tshwm sim ntawm kev ua tau zoo ntawm kev kho rau kev siv dej cawv, luam yeeb, ntau yam zaub mov noj, tshuaj homeopathic tsis tau tsim.

Hauv cov ntawv sau ua ke, los ntawm cov xov tooj incretin, nrog rau Onglisa, Galvus thiab Januvia raug tso tawm, hauv cov xaum qhuav - Baetu thiab Viktoza.

Tus kws tshaj lij thiab cov neeg siv ua haujlwm

Ntawm cov ncauj lus thematic txog cov tshuaj Ongliza, cov kev txheeb xyuas zoo kawg nkaus, tej zaum qhov tsis zoo tsuas yog tus nqi uas sib haum rau nws cov European zoo.

Hmoov tsis zoo, cov kab mob, xws li lub hnub nyoog laus, yog qhov tsis hloov thiab tsis tuaj yeem, vim tias kev noj qab haus huv, raws li koj paub, tsis tuaj yeem yuav, thiab hom mob ntshav qab zib hom 2 tsis yog lam tau lam ua hu ua ib daim pib.

Tab sis tus txiav ua ntshav qab zib nrog tus mob ntshav qab zib hom 2 tsis tau mob siab rau, nws muaj qhov tshwj tseg rau nws rov qab ua nws txoj haujlwm, thiab tso nws qhov kawg ua lub cev tsis muaj zog (los ntawm qhov pom ntawm insulin secretion) hloov ua ntej.

Ua ntej tso Ongliza mus rau kev ua lag luam, cov neeg tsim khoom siv nyiaj ntau lab nyiaj tsis yog los ua pov thawj qhov tsis muaj qhov cuam tshuam tsis zoo, tab sis tseem lees tias nws cov hauj lwm zoo. Yog tias cov tshuaj tsuas pab kho cov teeb meem ntev mus txog 10-20 xyoo, txawm hais tias lub sijhawm no puv ntoob (tsis muaj mob plawv, tsis nco qab, txhawm chim, dig muag, tsis muaj zog, mob raum tsis nco qab) lub neej, tsim nyog ua tib zoo mloog.

Cov lus hais txog qhov ua tau ntawm Onglisa thiab cov txiaj ntsig ntawm cov tshuaj mob ntshav qab zib rau kev noj qab haus huv ntawm endocrinologist Shmul Levit, lub taub hau. Lub koom haum ntawm Diabetology, saib cov yees duab:

Kev ntsuas rau siv

Ntawm hom 2 Ntshav Qab Zib, qhov cuam tshuam tsis haum ntawm cov hlwb rau qabzib yog tsawg. Nyob rau theem no, muaj kev ncua sijhawm nyob hauv thawj theem ntawm kev ua ke cov tshuaj hormones.

Nyob rau hauv lub neej yav tom ntej, theem ob tau ploj los vim tias tsis muaj qhov ntau ntxiv. Onglisa qeeb rau kis enzyme DPP 4, nce ntxiv nyob ntev hauv cov ntshav, insulin ntau dua yog tsim tawm. Glycemia ntawm qhov khoob thiab puv plab yog kho qhov ua haujlwm, lub cev ua haujlwm ntawm lub txiav ua rov qab. Yog li, Onglisa prolongs kev ua haujlwm ntawm lawv tus kheej cov tshuaj hormones, nce lawv cov ntsiab lus.

Cov tshuaj Onglisa uas muaj ntshav qab zib hom 2 (ntxiv rau kev noj zaub mov kom zoo thiab ua kis las) yog qhia raws li:

kev kho mob thawj zaug nrog ob peb tshuaj, ua ke nrog metformin,
ntxiv rau kev kho mob nrog metformin, insulin, sulfonylurea derivatives,
tshuaj mob hlwb.

Kev Siv Onglises txhim kho glycemic tswj.

Daim ntawv tso tawm

Lub teb chaws ntawm hauv paus chiv keeb - Tebchaws Asmeskas, tab sis cov ntsiav tshuaj npaj tau tuaj yeem ntim tau hauv tebchaws Askiv lossis Ltalis.

Lawv tau tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj puag ncig, convex ntawm ob sab, sab nraud yog coated. Txhua lub ntsiav tshuaj muaj tus lej xiav. Cov xim ntawm Onglisa yog nyob ntawm qhov kev saib xyuas ntawm cov khoom tseem ceeb: 2.5 mg ib qho yog xim daj ntseg daj ("2.5" yog sau rau ib sab, "4214" yog sau rau sab nraud), thiab 5 mg txhua yog paj yeeb (tooj "5" thiab "4215 ").

Cov ntsiav tshuaj yog ua blisters ua los ntawm txhuas ntawv nyiaj: hauv ib pob 3 blisters ntawm 10 daim. Txhua lub hlwv muaj qhov hluav taws xob perforation faib nws mus ua 10 qhov chaw (los ntawm cov ntsiav tshuaj). Cov thawv ntim khoom yog tiv thaiv los ntawm kev ua phem nrog cov ntawv nplaum pob tshab uas piav qhia lub daj daj.

Kev tsim kho hauv ntshav qab zib - tsuas yog haus txhua txhua hnub.

Koj tuaj yeem yuav cov tshuaj ntshav qab zib Onglizu hauv cov tsev muag tshuaj. Cov tshuaj yuav tsum muaj, tab sis tsis yog txhua tus kws muag tshuaj ua raws li txoj cai no. Hauv xyoo 2015, cov tshuaj tau suav nrog cov npe tseem ceeb, yog li yog muaj npe tshuaj ntshav qab zib, nws tuaj yeem nrhiav dawb.

Qhov nruab nrab, tus nqi ntawm kev ntim rau 30 ntsiav tshuaj yog txog 1800 rubles. Khaws cov tshuaj ntawm qhov kub tsawg dua 30 degrees ntawm cov menyuam yaus. Kev khaws cia yuav tsum tsis pub tshaj 3 xyoos.

Cov tshuaj phiv yog saxagliptin hydrochloride (2.5 lossis 5 mg). Qhov no yog tus sawv cev ntawm qhov niaj hnub inhibitor ntawm DPP-4.

Cov muaj mob:

MCC
lactose monohydrate,
croscarmellose sodium,
magnesium stearate,
hydrochloric acid
dyes.

Sab nrauv ntawm cov ntsiav tshuaj muaj OpadryII zas xim.

Cov lus qhia rau kev siv

Thaum kho mob nrog Onglisa pib, tus neeg mob yuav tsum hloov mus rau kev noj zaub mov zoo thiab kev ua lub neej nquag.Cov tshuaj ua rau mob me, yog li ntawd, thaum tsis muaj lub cev sib npaug thiab kev tawm dag zog, nws tsis muab nyiaj txaus rau cov piam thaj. Qhov siab tshaj plaws ntawm cov tshuaj nquag tau mus txog tom qab 150 feeb, cov nyhuv ntawm cov tshuaj nyob hauv 24 teev.

Ongliz yuav tsum tau noj nyob sab hauv ntawm lub sijhawm ywj pheej ntawm cov khoom noj khoom haus. Ib koob tshuaj raws li cov lus qhia yog 5 mg.

Yog tias kev sib xyaw ua ke tau pom zoo rau cov neeg mob ntshav qab zib, Ongliza siv nrog kev sib xyaw nrog metformin, sulfonylureas lossis thiazolidinediones.

Peb muab cov luv nqi rau cov nyeem ntawm peb lub xaib!

Thaum pib kho nrog metformin, ib koob tshuaj thaum pib theem yog 500 mg rau ib hnub. Nrog rau qhov tsis txaus ntseeg, cov koob tshuaj tau nce ntxiv.

Yog tias tus neeg mob tsis nco qab ntxiv cov tshuaj ntxiv lawm, txais tos yuav tsum rov kho dua sai dua. Hauv qhov no, tsis tas yuav tsum tau muab cov tshuaj kom ntau ntxiv.

Cov kws tshaj lij qhia txog kev kho mob sib xyaw nrog indinavir, ketoconazole thiab lwm yam nquag CYP 3A4 / 5 inhibitors 2.5 mg ib hnub.

Cov koob tshuaj yog txo kom tsawg dua 2.5 mg thaum kho nrog tshuaj tua kab mob thiab tshuaj tua kab mob.

Daim ntawv thov nta

Nyob rau theem pib ntawm kev hloov pauv ntawm kev ua haujlwm ntawm lub raum, tsis tas yuav hloov pauv qhov tsuas tshuaj. Hauv kev mob hnyav dua, kev mob hemodialysis, koob tshuaj pom zoo ntawm Ongliza tshuaj yog 2.5 mg ib hnub. Cov tshuaj tau raug pom zoo kom raug tswj hwm thaum txoj kev ua kom cov ntshav ua kom huv tiav. Ua ntej thiab thaum kho, nws yog qhov yuav tsum tau soj ntsuam kev mob ntawm lub raum.

Qhov cuam tshuam ntawm Onglises rau lub cev nrog txoj kev ua kom pom tseeb ntawm cov ntshav ua kom cov ntshav tsis tau tshawb xyuas.

Nrog rau kev hloov pauv ntawm daim siab kev ua haujlwm, tsis hais tus mob hnyav, tsis tas yuav hloov kho ib koob tshuaj.

Qhov tshwm sim ntawm kev siv Onglisa hauv cov neeg mob ntshav qab zib tshaj 65 xyoo zoo ib yam li ntawd hauv cov neeg mob hluas. Hauv cov hnub nyoog laus, koj yuav tsum tau noj tshuaj li niaj zaus noj txhua hnub. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias nyob rau theem ntawm txoj kev loj hlob no, kev ua haujlwm ntawm lub raum poob qis, qhov cuam tshuam hauv qee qhov ntau yog tawm ntawm lawv.

Tsis muaj cov ntaub ntawv hais txog qhov ua tau phom sij thiab cov txiaj ntsig zoo ntawm Onglisa tsis tau muaj 18 xyoo.

Co-administration ntawm Onglisa nrog cov tshuaj insulin thaum kho tsis tau tshawb xyuas. Tsis muaj cov ntaub ntawv hais txog cov nyhuv ntawm cov tshuaj ntawm kev tsav tsheb thiab kev ua ub no nrog cov kev siv tshuab. Kiv taub hau yuav tshwm sim tom qab noj cov tshuaj.

Cov txiaj ntsig ntawm cov tshuaj nquag ua rau lub cev ntawm cev xeeb tub thiab lactating tsis tau kawm. Tsis muaj ntaub ntawv qhia txog seb cov tshuaj nquag muaj peev xwm txeem tau los ntawm tus placenta mus rau tus me nyuam hauv plab thiab rau niam mis, yog li cov tshuaj tsis tau sau tseg rau lub sijhawm no. Yog tias nws tsis tuaj yeem zam kev siv Onglisa, lub sijhawm ntawm kev noj tshuaj, kev pub mis niam yog nres. Hauv qhov xwm txheej no, qhov ua rau muaj kev phom sij rau tus menyuam thiab qhov yuav tshwm sim zoo rau tus niam raug suav.

Sulfonylurea derivatives txo qis dua qib qabzib. Txhawm rau zam qhov kev tiv thaiv kab mob nrog kev kho mob sib xyaw nrog Onglisa, nws yog qhov tsim nyog los txo cov koob tshuaj sulfonylurea lossis insulin.

Nrog rau keeb kwm muaj kev tsis haum loj ntawm lub siab ntawm cov mob ntshav qab zib (suav nrog kev tsis haum tshuaj tam sim ntawd thiab Quincke's edema), Ongliza tsis tau siv thaum siv lwm cov tshuaj tiv thaiv DPP-4. Nws yog ib qho tsim nyog los txheeb xyuas qhov yuav ua rau muaj kev txo qis thiab pom zoo kom kho lwm yam (cov tshuaj tiv thaiv kab mob Onglisa).

Muaj cov ntaub ntawv pov thawj ntawm kev hnoos mob leeg nrog kev siv tshuaj. Cov neeg mob yuav tsum tau qhia txog cov kev xav zoo li no thaum sau ntawv Onglisa. Yog tias muaj qhov ntxim nyiam ntawm kev tshwm sim ntawm thawj cov tsos mob ntawm tus mob pancreatitis, cov tshuaj tau muab tshem tawm.

Cov tshuaj muaj pes tsawg leeg muaj cov lactose, yog li ntawd, cov neeg mob ntshav qab zib nrog kev mob caj dab galactose tsis haum, lactase tsis tuaj yeem siv Onglisa.

Kev cuam tshuam nrog lwm yam tshuaj

Cov kev kho mob yooj yim yog metformin nrog qhov xav tau ntawm kev hloov pauv hauv lub neej. Yog tias qhov kev kho mob no tsis coj qhov ua tiav qhov kev cia siab, yuav tsum tau pom zoo ntxiv cov tshuaj ntxiv.

Cov kev tshawb fawb tau ua uas pom tias muaj ntau yam me me ntawm kev sib txuam ntawm saxagliptin thiab lwm yam tshuaj.

Kev sib koom tes siv nrog inducers ntawm CYP 3A4 / 5 isoenzymes pab txo cov ntsiab lus ntawm saxagliptin metabolic khoom.

Kev noj sulfonylurea derivatives ua rau txo cov concentration ntawm cov piam thaj hauv cov ntshav. Txhawm rau kom tsis txhob muaj kev pheej hmoo, nws yog ib qho tsim nyog kom txo qis ntawm cov tshuaj Onglisa.

Tsis muaj kev tshawb fawb tau ua rau muaj kev cuam tshuam ntawm kev haus luam yeeb, kev noj zaub mov, lossis haus dej haus cawv ntawm saxagliptin.

Kev ceev faj txog kev ntsuas

Onglisa yog cov tshuaj muaj txiaj ntsig zoo, kev tsis xav pom qhov ua tau tshwm sim tsis tshwm sim. Muaj ntau qhov tshwm sim tsis zoo nrog saxagliptin li nrog cov tshuaj kho.

Siv Onglises yog nruj me ntsis txwv thaum:

ntshav qab zib hom 1
co-administration nrog cov kua dej
lactase deficiency,
mob ketoacidosis,
cev xeeb tub
pub niam mis
tsis tau muaj 18 xyoo
tus kheej tsis kam mus rau ib qho ntawm cov tshuaj ntawm cov tshuaj.

Nws yog qhov ua tau zoo heev rau cov neeg mob siv:

kev txom nyem los ntawm mob nyhav thiab tsis nco qab lub raum kev ua haujlwm lossis pancreatitis yav dhau los,
neeg laus neeg laus
nrog rau kev siv tib txhij nrog sulfonylureas.

Thaum kho nrog Onglisa, muaj qhov ntxim nyiam ntawm kev phiv:

mob txeeb zig
sab sauv ntawm txoj hlab ua pa tuaj
o ntawm lub qhov ntswg mucosa,
o ntawm lub plab thiab cov hnyuv me,
ntxhoo
mob txhaj thuv tas
yastes yastaw.

Nrog kev kho mob sib xyaw nrog metformin, nasopharyngitis ua tau nws tus kheej hauv qee kis.

Hypersensitivity tau sau tseg hauv 1.5% ntawm tus neeg mob, nws tsis yog hem neeg, thiab tsev kho mob tsis tas yuav tsum muaj.

Thaum noj ua ke nrog thiazolidinediones, kev txiav txim los ntawm kev txheeb xyuas ntawm Onglise, qhov tshwm sim ntawm qhov muaj zog lossis nruab nrab peripheral edema tau sau tseg, uas tsis tas yuav tsum tau txiav tawm txoj kev kho.

Qhov xwm txheej ntawm cov ntshav qog ntshav thaum kho nrog Ongliza tau ua tiav nrog cov txiaj ntsig nrog cov tshuaj placebo.

Noj ntau dhau

Nrog lub sijhawm ntev ntawm kev siv tshuaj, cov cim ntawm kev lom tsis piav qhia. Yog hais tias noj ntau dhau, cov tsos mob yuav tsum ua kom zoo siab. Cov tshuaj ua haujlwm nquag thiab nws cov khoom lag luam metabolic raug ntwm los ntawm hemodialysis.

Cov lus tsis sib xws Onglises nrog tib cov tshuaj nquag tsis muaj nyob. Nov yog cov tshuaj nkaus xwb nrog saxagliptin. Cov txiaj ntsig zoo sib xws ntawm lub cev tau siv los ntawm Nesin, Lub Sij Hawm, Galvus. Nws yog txwv tsis pub siv Ongliz analogues tsis tau kev tso cai los ntawm tus kws kho mob tuaj koom.

Cov tshuaj ntshav qab zib yuav pab tswj ntshav qabzib. Tshuaj yog qhov yooj yim txaus noj. Kuv tuaj yeem sau qhov kom zoo dua uas kuv tsis tuaj yeem saib xyuas ib qho kev mob tshwm sim. Ntawm cov minuses, Kuv tuaj yeem lub npe overpriced.

Kuv nyiam cov tshuaj Onglisa, muaj kev qhia meej rau kev siv, nws yooj yim siv. Qee zaum mob taub hau me ntsis tau tshwm sim. Kuv pom zoo cov tshuaj.

Ongliza cov tshuaj yog tus sawv cev rau ib pawg tshiab ntawm kev txo cov tshuaj qab zib. Nws muaj cov txheej txheem sib txawv ntawm qhov muaj zog, tab sis hais txog qhov ua tau zoo nws zoo ib yam li cov tshuaj ib txwm muaj, thiab hauv kev nyab xeeb nws muaj peev xwm dhau lawv. Cov tshuaj muaj qhov cuam tshuam zoo rau cov kab mob sib kis, tiv thaiv kev mob ntshav qab zib thiab muaj teeb meem.

Qhov tsis tshua muaj txiaj ntsig zoo yog qhov tsis muaj kev phom sij ntawm hypoglycemia, qhov cuam tshuam rau tus neeg mob qhov hnyav thiab siv tau nrog rau lwm cov tshuaj qab zib. Yav tom ntej, cov kws tshawb fawb npaj siab tsim cov tshuaj uas yuav ua kom rov ua haujlwm pancreatic kom ntev.