Dab tsi tuaj yeem hloov pauv Fraxiparin: analogues thiab txhais ntawm cov tshuaj
Hauv kev siv tshuaj, kws kho mob ntawm ntau qhov tshwj xeeb (hematologist, obstetrician-gynecologist, kws phais neeg) qee zaum ntsib cov kab mob hauv tsev kho mob uas xav tau kev tiv thaiv kab mob rau hauv lub cev ntawm lub cev. Tau ntev, cov kws kho mob tau siv cov tshuaj uas tuaj yeem hloov lub xeev kev ua haujlwm ntawm cov ntshav coagulation system. Sij hawm dhau mus, cov tshuaj zoo li no dhau los ua ntau dua, lawv cov kev ua tau zoo, thiab qhov tseem ceeb, lawv qhov kev nyab xeeb nce ntxiv. Tam sim no, ib qho ntawm cov tshuaj tiv thaiv kev puas tsuaj feem ntau yog Clexane, txawm li cas los xij, muaj qee qhov xwm txheej uas nws lub hom phiaj tsis yooj yim sua.
Hauv qee kis uas tus neeg mob tsis haum rau cov tshuaj rau qee qhov laj thawj, analogues rau kev teem caij yuav tsum raug xaiv los ntawm cov kws tshaj lij xwb. Koj tsis tuaj yeem hloov cov tshuaj ntawm koj tus kheej, vim tias qhov no tuaj yeem ua rau tsis muaj kev puas tsuaj rau kev noj qab haus huv.
Cov ntaub ntawv pharmacological dav
Nws yog cov tshuaj uas muaj cov nyhuv anticoagulant ncaj qha. Cov tshuaj muaj pes tsawg leeg suav nrog tshuaj suav nrog Enoxaparin sodium, uas ua cov tshuaj tseem ceeb uas siv los kho txhua yam tshuaj hauv lub cev. Muaj tshuaj rau ntau npaum li ntawm 20 txog 100 milligrams. Qhov tsim nyog xav tau yog xaiv coj mus rau hauv tus account pathology thiab kuaj ntsuas ntawm txhua tus neeg mob.
Lub tshuab kev ua ntawm kev ua raws li kev muaj peev xwm tiv thaiv qee yam coagulation (thib ob, xya thiab kaum). Yog li, cov tshuaj tau tuaj yeem cuam tshuam qhov xwm txheej ntawm kev tsim ntawm ntshav txhaws thiab thrombus. Kev txwv tsis pub muaj ntawm cov ntsiab lus saum toj no tshwm sim vim qhov ua haujlwm ntawm antithrombin 3, uas muaj nyob hauv cov ntshav.
Cov tshuaj no muaj nyob rau hauv daim ntawv ntawm qhov npaj-los-muab tshuaj, ntim rau hauv cov koob txhaj tshuaj tshwj xeeb rau kev tswj hwm subcutaneous. Daim ntawv tso tawm no tsim kev yooj yim rau kev siv yeeb tshuaj thiab tso cai rau cov neeg mob los pleev nws tus kheej, yav dhau los tau dhau los ntawm kev qhia luv nrog cov neeg kho mob.
Cov tshuaj no tau raug kho rau kev kho mob mob hnyav ntawm ntau cov laus. Tsis tas li, nws qhov kev siv tsuas yog qhia qhov tseeb txog kev tiv thaiv mob hauv cov neeg mob uas muaj kev pheej hmoo ntawm cov teeb meem thrombotic.
Ntawm qhov hloov pauv, peb tuaj yeem sib txawv cov tshuaj uas muaj qhov sib thooj sib luag, tab sis tsim tawm los ntawm lwm lub tuam txhab tshuaj, thiab cov uas muaj cov sib txawv, tab sis muaj cov nyhuv zoo ib yam li Clexane ntawm lub cev.
Hloov chaw tej zaum yuav tsim nyog yog tias tus neeg mob tau qhia cov cim ntawm tus neeg mob tsis haum rau tshuaj, ib qho kev mob tshwm sim thiab cov teeb meem. Tsis tas li, kev xaiv ntawm cov tshuaj pheej yig dua yog qhov yuav tsum tau ua thaum tus neeg mob tsis muaj nyiaj txaus los them cov tshuaj kho mob.
Clexane lossis Fraxiparin: uas yog qhov zoo dua
Fraxiparin yog ib qho tshuaj tiv thaiv tsis zoo. Txawm li cas los xij, nws muaj cov calcium nadroparin, uas hais txog cov roj heparins nyhav molecular tsawg. Cov tshuaj no tseem muaj nyob rau hauv daim ntawv ntawm cov koob txhaj uas muaj cov tshuaj npaj tau. Qhov tsis paub tseeb ntawm Fraxiparin yog nws tus nqi qis dua, uas ua rau nws them taus rau pawg ntau dua ntawm cov neeg mob. Cov lus qhia rau kev teem caij ntawm ob qho sib piv yeeb tshuaj
Gemapaksan lossis Kleksan: dab tsi los xaiv
Ob leeg ntawm cov tshuaj no muaj lub ntsej muag zoo ib yam, vim tias lawv tau ua raws tib yam khoom siv (enoxaparin). Daim ntawv teev npe ntawm cov cim taw qhia thiab contraindications rau qhov piav qhia txhais tau yog tib yam. Gemapaxan yog qhov pheej yig dua, txawm tias qhov tseeb tias nws tsim tawm txawv teb chaws (Ltalis). Tsis muaj ntaub ntawv ntseeg tau tias hom tshuaj no zoo dua thiab nyab xeeb. Cov kws kho mob uas feem ntau ua haujlwm nrog cov tshuaj no sib cav hais tias nws cov nyhuv yog tib yam. Cov teeb meem tshwm sim nrog kwv yees li ntawm tib zaus ntawm thawj zaug thiab tshuaj thib ob.
Sib piv cov yam ntxwv ntawm Pradaxa thiab Kleksan
Cov tshuaj muaj pes tsawg leeg ntawm Pradaxa suav nrog cov tshuaj yeeb tshuaj nquag Dabigatran etexilate, uas zwm rau cov pab pawg ncaj qha ntawm thrombin antagonists. Pradaxa nkag mus rau hauv tib neeg lub cev hauv daim ntawv tsis muaj zog. Tom qab nqus los ntawm lub plab zom mov mus rau hauv cov kab ke hauv lub cev, nws tau ua kom muaj kab mob hepatocytes vim yog lub enzymatic ntau thiab cov tshuaj sib xyaw uas nyob hauv lawv.
Raws li, cov neeg mob uas tau sau tseg rau Pradax yuav tsum tsis txhob muaj lub siab ua haujlwm tsis ua haujlwm, vim qhov no yuav muaj kev puas tsuaj ntxiv rau lub siab ua haujlwm.
Tseem Ceeb! Qhov zoo dua ntawm Pradaxa yog qhov ua tau ntawm tsis muaj kev tswj hwm tus thawj tswj hwm (muaj nyob hauv daim ntawv ntsiav tshuaj).
Heparin lossis Clexane: nws yog qhov zoo dua
Cov khoom ua si nquag ntawm Clexane yog ib qho kev tso dag los ntawm Heparin. Yog li, Heparin zoo li yog ib qhov hnyav ntawm cov phaus molecular hnyav, thiab Clexane yog qhov tsawg cov molecular hnyav compound. Clexane lub mis tau muab tau ntau tom qab, yog li cov tshuaj no muaj kev nyab xeeb dua thiab ua haujlwm zoo dua, thiab tseem yuav ua rau tsawg los ntawm kev txhim kho ntawm qhov tsis xav.
Nws yuav tsum nco ntsoov tias qhov kev pheej hmoo ntawm kev txhim kho xws li kev tsis txaus siab los ntawm kev siv heparin, raws li autoimmune thrombocytopenia, mob siab rau thaum muab tshuaj rau nws cov txiaj ntsig tsis tshua muaj molecular hnyav.
Zibor ua ib qho analog
Lub chaw sib xyaw ua ke ntawm Zibor yog cov ntsev ntsev ntawm lub cev tsis tshua muaj molecular hnyav heparin (sodium bemiparin). Cov tshuaj no yog siv dav hauv kev phais mob thiab hauv nephrology (nws tau raug kho rau cov neeg mob ua tus neeg mob ntxiv rau ntawm lub raum nyob ntawm lub raum ua haujlwm). Lub tshuab ntawm kev txiav txim ntawm Zibor yog ua tiav zoo sib xws, vim tias cov tshuaj no inhibits thrombosis vim cuam tshuam ntawm coagulation cascade. Zibor tuaj yeem siv tsis tau rau menyuam yaus vim qhov tseeb tias tseem tsis tau muaj kev tshawb fawb txaus txog qhov tshwm sim ntawm cov tshuaj no rau menyuam lub cev.
Enixum thiab Clexane: kev sib piv tshuaj
Cov tshuaj sib xyaw ntawm cov tshuaj sib piv suav nrog tib lub tshuaj sib txuas, uas txiav txim siab qhov zoo sib xws ntawm cov tshuaj no. Enixum raws li Clexane tau muaj nyob hauv cov ntawv txhaj tshuaj npaj rau kev tswj hwm subcutaneous. Cov tshuaj muaj nyob rau hauv yim qhov sib txawv, uas yuav ua rau tus kws kho mob xaiv qhov muaj peev xwm xav tau ntau tshaj plaws thiab kev nyab xeeb kev xav ntawm kev daws rau tus neeg mob.
Feem ntau, Enixum yog ntawv pov thawj raws li cov lus tshaj tawm rau cov neeg mob ntawm cov tsev kho mob phais neeg uas tau ua haujlwm ntau lawm (tshwj xeeb tshaj yog kev phais mob ntawm cov leeg mus rau hauv cov leeg).
Enoxaparin sodium yog ib qho tshuaj ntawm Clexane
Cov tshuaj muaj pes tsawg leeg ntawm ob hom tshuaj yog zoo tib yam, yog li ntawd, txhua qhov kev qhia thiab sib kis rau lawv siv yog tib yam. Ob qho Enoxaparin sodium thiab Clexane yog tswj hwm los ntawm kev txhaj tshuaj subcutaneous, uas tsis yog qhov txheej txheem zoo nkauj rau ntau tus neeg mob.
Nyob rau hauv rooj plaub thaum nws tsis tuaj yeem tswj hwm kev haus tshuaj kom zoo, Enoxaparin sodium tsis tuaj yeem hloov pauv. Cov kev tshawb fawb uas tuaj yeem hais meej tias qhov twg ntawm cov tshuaj ua tau zoo dua tsis tau coj los ua, tab sis hauv kev coj ua lawv qhov kev ua tau zoo thiab qhov ua tau zoo yuav luag sib npaug.
Npe | Nqi | |
---|---|---|
Clexane | los ntawm 176.50 rub. mus txog 4689.00 rub. | nkaum pom cov nqi hauv kev nthuav dav |
Pradaxa | los ntawm 1777.00 rub. mus txog 9453.00 rub. | nkaum pom cov nqi hauv kev nthuav dav |
Fraxiparin | los ntawm 2429.00 rub. mus txog 4490.00 rub. | nkaum pom cov nqi hauv kev nthuav dav |
Lwm yam kev hloov pauv pheej yig dua
Clexane yog cov tshuaj pheej yig, tshwj xeeb tshaj yog thaum koj xav tias koj yuav tsum pleev rau nws hauv tag nrho cov kev kawm. Tom ntej no, peb muab cov npe tshuaj uas tuaj yeem hloov cov tshuaj no, tab sis tus nqi qis dua:
Npe | Nqi | |
---|---|---|
Fenilin | los ntawm 37.00 rub. mus txog 63.00 rub. | nkaum pom cov nqi hauv kev nthuav dav |
Clexane | los ntawm 176.50 rub. mus txog 4689.00 rub. | nkaum pom cov nqi hauv kev nthuav dav |
Fragmin | los ntawm 2102.00 rub. mus txog 2390.00 rub. | nkaum pom cov nqi hauv kev nthuav dav |
Lub Npe Tsis Muaj Npe International
Lub npe tsis tseem ceeb hu ua Fraxiparin, uas qhia txog kev sib xyaw ntawm cov tshuaj yeeb yaj kiab, yog Nadroparin calcium, lub npe Latin thoob ntiaj teb yog Nadroparinum calcium.
Cov tshuaj Fraksiparin 0.3 ml
Txhua qhov kev lag luam ntau heev ntawm cov tshuaj, sib koom ua ke los ntawm ib lub npe tsis tseem ceeb, muaj tib lub txiaj ntsig ntawm tib neeg lub cev rau cov yam ntxwv thiab siv.
Ntxiv rau lub npe, qhov sib txawv ntawm cov tshuaj uas sib txawv ntawm cov neeg tsim khoom yog nyob hauv qhov ntau npaum li cas, zoo li nyob rau hauv kev sib xyaw ua ke ntawm excipients thiab biologically thiab chemically neutral excipients tam sim no hauv cov tshuaj.
Chaw tsim tshuaj paus
Cov tshuaj hu ua Fraxiparin yog tsim tawm hauv Fabkis ntawm cov chaw tsim khoom lag luam nyob hauv lub chaw muag tshuaj thib ob loj tshaj plaws nyob hauv Europe, GlaxoSmithKline, uas lub chaw haujlwm nyob hauv London.
Txawm li cas los xij, cov tshuaj no kim heev, yog li kev lag luam kws tsim khoom lag luam tsim tawm nws ntau yam duab tsis zoo.
Feem ntau cov pheej yig tshaj tawm yog:
- Nadroparin-Farmeks uas ua los ntawm Farmeks-Group (Ukraine),
- Novoparin tsim los ntawm Genofarm Ltd (UK / Tuam Tshoj),
- Flenox uas ua los ntawm PAO Farmak (Ukraine),
Cov khoom lag luam zoo ib yam kuj tau tsim los ntawm cov tuam txhab Indian thiab European cov tuam txhab ua lag luam. Raws li kev cuam tshuam ntawm lub cev, lawv tau ua tiav analogues.
Pharmacological kev txiav txim
Calcium nadroparin yog qhov tsawg molecular phaus heparin (NMH) tau los ntawm depolymerization los ntawm tus qauv heparin, yog glycosaminoglycan nrog qhov nruab nrab molecular hnyav ntawm 4300 daltons.
Nws ua kom pom lub peev xwm loj tuaj yeem khi rau ntshav plasma protein nrog antithrombin III (AT III). Qhov khi no ua rau muaj kev nrawm nrawm ntawm qhov xa Tau X, uas yog vim muaj qhov muaj peev xwm ntawm antithrombotic siab ntawm nadroparin.
Lwm yam kev ua haujlwm muab cov txiaj ntsig antithrombotic ntawm nadroparin muaj xws li kev ua haujlwm ntawm lub cev nqaij daim tawv hloov dua siab tshiab (TFPI), kev ua haujlwm ntawm fibrinolysis los ntawm kev tawm ncaj qha ntawm cov nqaij mos plasminogen activator los ntawm endothelial hlwb, thiab kev hloov kho ntawm cov ntshav rheological (txo cov ntshav viscosity thiab nce permeability ntawm platelet thiab granulocyte membranes).
Calcium nadroparin yog tus cwj pwm los ntawm kev ua haujlwm siab dua-Xa qhov kev ua haujlwm piv rau qhov cuam tshuam anti-IIa los yog antithrombotic kev ua haujlwm thiab muaj ob qho kev ua tam sim thiab ntev antithrombotic.
Muab piv rau cov tshuaj heparin tsis sib haum xeeb, nadroparin muaj cov nyhuv qis dua ntawm cov platelet muaj nuj nqi thiab kev sib sau ua ke, thiab cov lus hais tsawg dua rau ntawm kev kho mob hemostasis.
Hauv koob tshuaj prophylactic, nadroparin tsis ua rau muaj qhov txo qis hauv APTT.
Nrog rau kev kho mob lub sijhawm lub sijhawm ua haujlwm siab tshaj plaws, kev nce qib hauv APTT rau tus nqi 1.4 lub sijhawm siab dua li tus qauv yog ua tau. Xws li lub caij nyoog ntev ua kom pom qhov muaj qhov ua tau antithrombotic ntawm calcium nadroparin.
Cov Tshuaj Pharmacokinetics
Cov cuab yeej pharmacokinetic tau txiav txim siab los ntawm cov kev hloov pauv ntawm qhov cuam tshuam anti-Xa yam kev ua haujlwm ntawm ntshav.
Tom qab kev tswj fwm Cmax hauv cov ntshav ntshav tau tiav tom qab 3-5 teev, nadroparin yuav nqus yuav luag tag nrho (li 88%). Nrog rau / hauv cov lus qhia txog qhov siab tshaj plaws los tiv thaiv XA kev ua haujlwm tau tiav hauv tsawg dua 10 feeb, T1 / 2 yog li 2 teev
Nws yog metabolized feem ntau hauv lub siab los ntawm desulfation thiab depolymerization.
Tom qab SC coj T1 / 2 yog txog 3.5 teev. Txawm li cas los xij, cov haujlwm tiv thaiv Xa-mob tseem muaj tsawg kawg 18 teev tom qab txhaj tshuaj nadroparin ntawm koob tshuaj 1900 los tiv thaiv XA ME.
Dosage daim ntawv
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm kev daws rau kev txhaj tshuaj. Nyob ntawm cov chaw tsim khoom thiab ntau yam, ntau txoj kev xaiv ntau qhov tuaj yeem pom.
Qhov feem ntau muaj xws li kev kho mob ntawm 0.2, 0.3, 0.6 thiab 0.8 millilitres. Cov chaw tsim khoom ntawm cov tuam txhab German Aspen Pharma tuaj yeem xa hauv qhov ntau thiab tsawg ntawm 0.4 millilitres.
Sab nraud, txoj kev daws yog cov kua tsis muaj roj, tsis muaj kob los yog daj.Cov tshuaj kuj tseem muaj tus cwj pwm tsis hnov tsw. Ib qho tshwj xeeb ntawm Fraxiparin yog tias txoj kev daws teeb meem tsis yog muab rau hauv cov ampoules uas tsis paub txog peb cov neeg siv khoom, xav tau kev yuav khoom ntawm cov khoom siv pov tseg ntawm qhov muaj peev xwm tsim nyog thiab qee yam kev ntxias ua ntej kev txhaj tshuaj.
Cov tshuaj raug muag hauv cov tshuaj tshwj xeeb pov tseg uas siv, npaj txhij rau kev siv. Txhawm rau txhaj koob tshuaj, nws txaus kom tshem lub tiv thaiv lub hau los ntawm rab koob thiab nias ntawm qhov piston.
Lub ntsiab active tshuaj
Qhov no polysaccharide cais tawm ntawm daim siab yog ib qho zoo anticoagulant.
Ib zaug hauv cov ntshav, heparin pib khi rau qhov chaw cationic ntawm tri-antithrombin.
Raws li qhov tshwm sim ntawm qhov no, antithrombin lwg me me hloov pauv lawv lub zog thiab ua yeeb yam rau cov enzymes thiab cov protein ua lub luag haujlwm rau cov ntshav coagulation, tshwj xeeb, ntawm thrombin, kallikrein, ntxiv rau cov pheem proteases.
Txhawm rau cov tshuaj kom ua tau ntau dua thiab nrawm dua, nws qhov pib "ntev" polymer cov kua dej tau muab faib ua luv luv los ntawm depolymerization nyob rau hauv cov kev mob tshwj xeeb ntawm cov khoom siv ua cov khoom siv.
Cev xeeb tub analogues
Cov tshuaj Fraxiparin siv ntau zaus thaum cev xeeb tub.
Tseeb, nyob rau lub sijhawm no, vim yog hloov cov keeb kwm ntawm keeb kwm, qhov khoom coagulant ntawm cov ntshav nce ntxiv, uas tuaj yeem ua rau lub nra hnyav. Dab tsi analogues ntawm cov tshuaj yog tsim nyog noj thaum coj cov menyuam hauv plab?
Ntau zaus, Angioflux yog siv - sib xyaw ntawm heparin-zoo li feem, uas tau muab rho tawm los ntawm cov hnoos qeev ntawm nqaim plab hnyuv ntawm npua hauv tsev. Ob qho tshuaj ntsiav ntawm qhov ncauj thiab ntau qhov kev daws teeb meem zoo rau kev txhaj tshuaj muaj.
Lwm qhov analog uas tau siv dav thaum cev xeeb tub yog hepatrombin. Raws li cov tshuaj muaj pes tsawg leeg, nws yog ib qho tseeb ntawm Fraxiparin, tab sis txawv hauv cov ntawv tshuaj. Tsis zoo li tom kawg, hepatrombin muaj nyob rau hauv daim ntawv ntawm tshuaj pleev rau kev siv sab nraud.
Thaum kawg, Wessel Douay F npaj, muaj ib qho sib xyaw ntawm polysaccharides - glycosaminoglycans, kuj muaj cov nyhuv zoo ib yam li Fraxiparin. Lawv txoj kev tswj hwm tseem ua rau cov ntshav coagulation factor X nrog rau kev ua kom cov prostaglandins sib txig sib luag thiab txo cov fibrinogen hauv cov ntshav.
Pheej pheej yig analogues
Hmoov tsis zoo, zoo li feem ntau cov khoom lag luam nyob sab Europe, Fraxiparin nws kim heev. Txawm li cas los xij, nws muaj nws cov pheej yig cov khoom siv uas tso cai rau kev tiv thaiv thiab kev kho mob ntawm thrombotic manifestations thiab txuag nyiaj. Cov tshuaj tsis pheej yig tshaj plaws ntawm cov tshuaj no yog cov tshuaj nyob hauv Suav teb, Is Nrias teb thiab CIS.
Siv cov tshuaj txhaj Enoxaparin-Farmeks
Superiority hauv kev nkag tau yog tuav los ntawm cov tshuaj hauv qab cov npe lag luam Eneksaparin-Farmeks ntawm keeb kwm Ukrainian. Hauv kev npaj ntawm lub tuam txhab "Farmeks-Group", cov khoom tseem ceeb tseem yog co-molecular, uas yog, tsis txaus ntseeg, heparin.
Tsis kim npaum li Enoxarin uas ua los ntawm Biovita Lub chaw soj nstuam - muaj cov kws tshuaj Indian coob. Nws kuj los hauv cov phwj huv uas tshwj xeeb thiab muaj cov tshuaj zoo sib xws - calcium uas muaj "heparin" luv luv.
Ib qho uas hloov tau heev rau Fraxiparin yog tshuaj uas hu ua Clexane. Fabkis cov tshuaj lag luam koom nrog kev tsim khoom, uas tuaj yeem lav qhov zoo ntawm cov tshuaj thiab kev nyab xeeb ntawm nws cov thawj coj.
Qhov sib txawv ntawm Fraksiparin los ntawm Kleksan
Clexane yog qhov txawv los ntawm tus nqi ntau dua, tab sis nws yog txiav txim siab los ntawm ntau tus kws kho mob tau txiav txim siab tias nws yog qhov yooj yim tshaj plaws thiab muaj txiaj ntsig anticoagulant thaum cev xeeb tub.
Kev yooj yim ntawm kev siv Clexane lus dag hauv lub caij nyoog ntev, txheeb ze rau Fraxiparin, ua rau lub cev muaj zog.
Clexane Kev Txhaj Tshuaj
Raws li kev coj ua nquag, nws yog ib qho tsim nyog los tswj hwm Fraxiparin ib hnub ob zaug. Tib lub sijhawm, Clexane muaj cov nyhuv hauv 24 teev, uas yuav txo tau cov neeg siv ib nrab los ntawm ib nrab.
Tau hais tias qhov tshuaj no tau noj rau lub sijhawm ntev, kev txo qis ntawm cov naj npawb txhua hnub ntawm kev txhaj tshuaj yog qhov zoo dua rau kev mob siab rau tus neeg mob thiab lub cev.
Txwv tsis pub, cov tshuaj no zoo ib yam nkaus thiab tsis txawv nyob rau hauv daim ntawv tso tawm, lossis hauv cov tshuaj nquag, lossis hauv tshuaj tiv thaiv ntawm lub cev rau lawv cov kev tswj hwm.
Fraxiparin lossis Heparin
Txawm li cas los xij, nyob rau lub sijhawm nws tau nce los ua los ntawm Fraxiparin thiab nws cov analogues.
Lub tswv yim hais tias Heparin hla dhau qhov chaw placental thiab tuaj yeem muaj qhov tsis zoo rau tus me nyuam hauv plab yog qhov tsis tsim nyog.
Raws li kev tshawb nrhiav, ob qho tib si Fraxiparin thiab Heparin tsis qhia lub peev xwm los nkag rau ntawm tus txiv neej thiab tuaj yeem muaj qhov tsis zoo rau tus menyuam hauv plab tsuas yog qhov tshuaj tau tso cai tau tshaj.
Qhov ntau ntawm Fraxiparin hauv kev kho mob niaj hnub tau piav qhia tsuas yog los ntawm qhov yooj yim ntawm nws siv - txwv tsis pub cov tshuaj muaj qhov sib luag.
Fraxiparin lossis Fragmin
Fragmin, zoo ib yam li lwm yam tshuaj hauv pawg, muaj cov tshuaj heparin. Txawm li cas los xij, Fragmin yog siv los ua cov coagulant, tsis zoo li Fraxiparin, tsim rau siv thaum cev xeeb tub.
Fragmin kev txhaj tshuaj
Yog tias tom kawg muaj cov calcium calcium ntawm cov tshuaj nquag, tom qab ntawd Fragmin muaj cov ntsev ntsev ntawm polymerized heparin. Muaj pov thawj tias hauv qhov no, Fragmin muaj kev cuam tshuam loj dua rau lub cev.
Hauv cov txheej txheem ntawm kev noj cov tshuaj no, los ntshav los ntawm cov hlab ntsha me yog ntau dua. Hauv tshwj xeeb, kev siv cov Fragmin tuaj yeem ua rau lub qhov ntswg tsis xwm yeem, nrog rau cov pos hniav los ntshav ntawm cov neeg mob.
Related videos
Yuav ua li cas rau kev txhaj tshuaj subcutaneous ntawm Clexane:
Nyob rau hauv dav dav, muaj txog ib lub kaum os ua tiav analogues ntawm Fraxiparin, uas sib txawv hauv ob tog nqi ntau dua lossis kev nqis tes ua lub sijhawm ntev, thiab tso cai rau koj kom txuag tau nyiaj los ntawm kev tawm tsam cov kab mob ntshav sib xyaw nrog kev saib xyuas thaum lub sijhawm cev xeeb tub lossis nrog kev cuam tshuam enzymatic.
- Stabilizes qib qab zib kom ntev
- Rov kho cov tshuaj insulin pancreatic
Moog kawm ntawv ntxiv. Tsis yog qaug tshuaj. ->
Isoprinosine® - analogues yog pheej yig dua, tus nqi ntawm Lavxias thiab kev hloov pauv txawv
Siv tau Zoo thiab Nqis Isoprinosine Hloov Chaw
Nyob rau lub caij nplooj zeeg-lub caij ntuj no, tib neeg lub cev yuav raug tshwj xeeb rau ntau kis mob kis.
Lub sijhawm no, txhua tus yuav tsum muaj cov tshuaj tua kabmob muaj txiaj ntsig zoo rau hauv tsev. Ib cov tshuaj yog Isoprinosine®.
Cov tshuaj yog siv tau zoo, tab sis tsis yog txhua tus neeg mob yuav txaus siab nws cov nqi hauv cov khw muag tshuaj. Yog li ntawd, nws raug nquahu kom xav txog dab tsi pheej yig cov tshuaj ntawm cov tshuaj muaj nyob.
Cov nyhuv tshuaj
Isoprinosine yog ib qho tshuaj tiv thaiv kab mob (immunostimulating) nrog cov nyhuv antiviral. Nws muaj 4-acetamidobenzoic acid thiab inosine.
Qhov thib ib feem txhim kho kom hla ntawm cov ntshav thiab nws cov khoom tseem ceeb los ntawm daim nyias nyias. Ua tsaug rau nws, kev ua haujlwm ntawm lymphocytes nce ntxiv, thiab kev hais tawm ntawm cov khoom siv membrane tau kho. Lymphocyte cov hlwb txo cov haujlwm vim qhov tshwm sim rau glucocorticoids, thiab suav nrog thymidine hauv lawv.
Qhov thib ob tivthaiv cov haujlwm ntawm cytotoxic lymphocytes, txwv tsis pub tsim cov cytokines inflammatory.
Inosine nquag tawm tsam cov kab mob ntawm tus mob herpes simplex, qhua pias, mob khaub thuas A, B. Qhov tseem ceeb tshaj plaws yog kev kho tus mob herpes.
Thaum lub sijhawm saib xyuas cov tshuaj, muaj kev nrawm nrawm ntawm qhov chaw mob txhab ntau dua li lwm yam, kev kho mob ib txwm muaj.
Qhov tshwm sim ntawm kev rov huam dua nyob rau hauv daim ntawv ntawm qhov pom ntawm cov hlwv tshiab, cov txheej txheem ntawm kev yaig thiab edema tsis zoo li. Hauv qhov no, kev pib kho mob kom raws sijhawm yog qhov tseem ceeb, uas yuav txo qhov hnyav thiab lub sijhawm ua haujlwm ntawm tus kabmob.
Cov Yuav Tsum Tau Ua
Yuav tsum tsis txhob coj:
- Rau cov teeb meem nrog lub assimilation ntawm cov tshuaj,
- Cov neeg mob gout
- Cov neeg uas muaj mob raum ntau yam,
- Nrog urolithiasis,
- Cov poj niam nyob hauv txoj hauj lwm thiab lub sijhawm pub niam mis,
- Cov menyuam yaus hnub nyoog qis dua 3 xyoos thiab hnyav dua li 20 kg.
Tej zaum cov kev mob tshwm sim
- Kev ua haujlwm tsis zoo ntawm lub hauv nruab nrab lub paj hlwb - mob taub hau, ua tiav sai sai ntawm ib qho zoo nkaus li qaug zog,
- Tsis ua haujlwm ntawm lub plab zom mov - teeb meem tsis qab los, ntuav, raws plab,
- Teeb meem hauv qhov system musculoskeletal - mob sib koom tes,
- Ua xua - npog daim tawv nqaij ua pob xoo, urticaria.
Yuav noj cov isoprinosine li cas?
Cov lus qhia rau kev siv cov ntsiav tshuaj rau cov neeg laus thiab cov menyuam yaus:
- Cov neeg laus yam tsawg 500 mg thiab tsis ntau dua 4 g ib hnub,
- Cov koob tshuaj rau cov menyuam yaus hnub nyoog qis dua 12 xyoos yog xam los ntawm cov mis 50 mg rau ib kg ntawm lub cev qhov hnyav hauv ib hnub.
- Rau cov neeg laus thiab menyuam yaus, kev siv tshuaj ntau ntxiv yog tso cai rau cov mob hnyav mob ntawm cov hom phiaj rau kev kho mob. Tib yam siv rau zaus ntawm kev tswj hwm, lub sijhawm kho.
Cov kev qhia tshwj xeeb ntawm kev kho kom zoo
- Cov txiaj ntsig ntawm kev kho mob nce ntxiv yog tias cov tshuaj tau pib los ntawm thawj hnub ntawm tus kabmob,
- Nws yog ib qho tsim nyog yuav tau soj ntsuam cov concentration ntawm uric acid hauv cov zis thiab ntshav, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj kab mob siab
- Cov tsav tsheb ntawm cov tsheb thiab lwm cov txheej txheem uas xav tau tshwj xeeb yuav tsum paub tias cov tshuaj muaj peev xwm cuam tshuam lawv cov kev ua, ua rau kiv taub hau thiab mob siab rau pw tsaug zog. Qhov no tuaj yeem cuam tshuam kev nyab xeeb.
Kev cuam tshuam nrog lwm yam tshuaj
- Concurrent administration ntawm immunosuppressants txo cov nyhuv ntawm isoprinosine,
- Qhov kev siv ntau ntawm allopurinol thiab ntau yam tshuaj diuretics, suav nrog furosemide thiab ethacrylic acid, ua rau muaj kev nce qib ntawm uric acid hauv cov ntshav,
- Siv zidovudine ua ke nce qib ntawm zidovudine hauv cov ntshav.
Cov npe ntawm cov analogues muaj ntawm cov ntsiav tshuaj ntawm Lavxias teb sab thiab txawv teb chaws ntau lawm
Cov tshuaj Analogues yog pheej yig dua Isoprinosine | Apteka.ru (tus nqi hauv rubles) | Piluli.ru (nqe hauv rubles) | ||
Moscow | SPb | Moscow | SPb | |
Groprinosin (Daim ntawv foos) | 555 | 571 | 636 | 565 |
Amixin (ntsiav tshuaj) | 598 | 598 | 589 | 535 |
Lavomax (tab.) | 540 | 554 | 533 | 436 |
Arbidol (tsiav tshuaj) | 476 | 490 | 475 | 425 |
Ergoferon (lub rooj) | 346 | 359 | 324 | 293 |
Tilaxin (lub rooj) | – | – | 214 | 222 |
Alpizarin (rooj) | 216 | 225 | 199 | 171 |
Hyporamine (lub rooj) | 182 | – | 159 | 127 |
Amiksin - (Lavxias chaw tsim tshuaj paus)
Kev muaj peev xwm tiv thaiv tus mob herpetic, tus mob kis kab mob siab A, B, C, mob npaws thiab SARS. Nws yog tus cwj pwm los ntawm kev muaj peev xwm los tawm tsam ntau tus sclerosis, urogenital thiab ua pa chlamydia.
Cov kev xav tsis zoo ntawm lub plab zom plab yog qhov xwm txheej. Ntxiv rau, kev tsis haum tshuaj yog muaj peev xwm ua tau.
Lavomax - (kev lag luam hauv tsev)
Nws ua tiav cov sib tw, ob qho tib si hauv kev sau thiab hauv kev coj ua nrog cov cuab yeej yav dhau los. Ib yam li Amixin, nws raug pom zoo rau kev tawm tsam txhua yam kab mob siab, mob pob txuv. Ntxiv rau, nws tiv taus ntau yam mob sclerosis, khaub thuas thiab SARS.
Nyob rau hauv daim ntawv ntawm kev puas tsuaj concomitant tshwm sim, kev ua xua, kev zom plab tsis txaus, thiab zoo nkaus li ua daus no tsis suav nrog.
Ergoferon - (pheej yig Lavxias teb sab analogue)
Paub cov tshuaj siv los tiv thaiv kab mob nrog rau ntau cov cim qhia. Nws lub peev xwm suav nrog kev tiv thaiv kev tiv thaiv thiab kho tus mob khaub thuas A, B, ntau yam mob ua pa ua kis mob yooj yim.
Nws tseem yuav pab kom kov yeej tau tus mob herpesvirus. Ergoferon pom qhov txawv los ntawm kev tawm tsam zoo tiv thaiv kev mob plab hnyuv, uas tau ua rau muaj cov kab mob sib txawv.
Tiv thaiv thiab tiv thaiv tus mob meningitis, mob ntsws, mob hawb pob.
Tilaxin - (Russia)
Nws muaj kev sib thooj nrog Amiksin thiab Lavomaks. Nws kho cov kab mob ua pa rau khaub thuas, mob khaub thuas, kis kab mob siab, mob pob khaus. Nws kuj tseem raug sau tseg tias yog kev kho mob kho rau encephalomyelitis, mob chlamydia, mob ntsws qhuav.
Cov kev xav tsis zoo ntawm tus neeg mob lub cev yog kev cuam tshuam ntawm lub plab zom mov, ua daus no ib ntus thiab ua xua.
Alpizarin - (RF)
Nws tshwj xeeb hauv kev kis cov tawv nqaij thiab cov qog ua kua uas tau tshwm sim los ntawm tus mob herpes. Tiv thaiv nrog Kaposi's sarcoma, warts, viral dermatoses, suav nrog lichen.
Nws sawv rau nws cov voluminous cov npe ntawm cov kev mob tshwm sim. Ntuav, ua kom tsis muaj zog ntawm txoj hnyuv, mob taub hau, qaug zog, ua pob ntawm daim tawv nqaij.
Cov lus xaus hais txog generics pheej yig thiab siv tau
Tau suav tias yog tshuaj tua kab mob los tiv thaiv kab mob, nws tsim nyog hais tawm tias nws muaj lub koob npe zoo hauv khw muag tshuaj hauv tsev. Nyob rau tib lub sijhawm, tus nqi rau Isoprinosine yog tus nqi ntau thiab yuav cuam tshuam rau kev nyiaj txiag ntawm cov neeg mob.
Hauv kev ua lag luam hauv tsev, cov tuam txhab ua lag luam tau tsim cov tshuaj feem ntau nyob ntawm tus nqi pheej yig.
Ua ntej koj yuav hloov chaw, koj yuav tsum mus ntsib kws kho mob ntawm tus kws paub txog kev kis tus mob, uas, tau txiav txim siab tus mob yav dhau los, yuav tsim kom muaj txoj kev kho mob.
Cov tshuaj ntawm cov tshuaj Fraxiparin
Sau cov npe tawm
Nadroparin calcium (Nadroparin calcium) Anticoagulant cov tshuaj ncaj qha rau kev tswj hwm subcutaneous
Nws muaj cov nyhuv antithrombotic. Tsawg molecular yuag heparin tau los ntawm cov qauv txheej txheem ntawm depolymerization.
Hauv kev sib txuas nrog antithrombin III, nws yog tus cwj pwm los ntawm cov haujlwm ua tshaj tawm tiv thaiv kev sib raug zoo XA thiab tsis muaj zog tiv thaiv tus yam ntxwv IIa.
Txhim kho cov txiaj ntsig kev thaiv ntawm antithrombin III rau yam XA, uas ua rau kev hloov pauv ntawm prothrombin rau thrombin. Kev tiv thaiv ntawm qhov ntsuas XA tshwm nyob rau ntawm 200 200 PIECES / mg, thrombin - 50 PIECES / mg. Anti-XA kev ua si yog qhov muaj tseeb ntau tshaj li qhov tshwm sim ntawm APTT. Nws muaj lub txiaj ntsig sai thiab kav ntev. Cov haujlwm muaj qhia nyob rau hauv cov koog ntawm European Pharmacopoeia (Ph. Eur.) IU-anti-Xa.
Nws muaj cov tshuaj tiv thaiv thiab txhaj tshuaj tiv thaiv kab mob (tiv thaiv kev sib koom tes ntawm T- thiab B-lymphocytes) cov yam ntxwv, txo qis me ntsis ntawm cov roj cholesterol thiab beta-lipoproteins hauv cov ntshav. Kho txhim kho cov ntshav hlab ntshav khiav.
Kev tiv thaiv ntawm kev mob thromboembolic (suav nrog cov kev txuam nrog kev phais mob dav dav, oncology thiab orthopedics, hauv cov neeg mob uas tsis yog phais mob nrog qhov kev pheej hmoo siab ntawm kev mob thom khwm: mob ua pa tsis ua haujlwm, purulent-septic kab mob, mob plawv tsis ua haujlwm), kev tiv thaiv cov ntshav coagulation thaum hemodialysis.
Kev kho mob ntawm thrombosis thiab thromboembolism, tsis khov kho lub hlwb thiab myocardial infarction tsis muaj Q yoj.
Daim ntawv thov thiab qhov ntau npaum li cas
Nkag mus rau hauv daim tawv nqaij me me hauv plab, nkag mus rau qhov tuab ntawm daim tawv nqaij (rab koob yog txiav raws daim tawv nqaij). Cov khawm quav yog tswj xyuas thoob plaws hauv lub sijhawm tswj hwm.
Kev tiv thaiv ntawm thromboembolism hauv kev phais mob dav dav: 0.3 ml 1 zaug ib hnub. 0.3 ml yog muab 2-4 teev ua ntej phais. Lub sijhawm kho mob yog tsawg kawg 7 hnub.
Rau cov hom phiaj kho: muab 2 zaug ib hnub rau 10 hnub ntawm ib koob 225 U / kg (100 IU / kg), uas sib raug: 45-55 kg - 0.4-0.5 ml, 55-70 kg - 0.5-0.6 ml, 70 -80 kg - 0.6-0.7 ml, 80-100 kg - 0.8 ml, ntau tshaj 100 kg - 0.9 ml.
Hauv kev phais orthopedic, cov koob tshuaj yog xaiv raws qhov hnyav lub cev. Nws raug tswj hwm ib zaug ib hnub ib hnub, nyob rau hauv cov koob tshuaj hauv qab no: nrog lub cev qhov hnyav tsawg dua 50 kg: 0.2 ml nyob rau lub sijhawm preoperative thiab tsis pub dhau 3 hnub tom qab phais mob, 0.3 ml nyob rau lub sijhawm tom qab (pib txij li 4 hnub).
Nrog lub cev qhov hnyav ntawm 51 txog 70 kg: hauv lub sijhawm preoperative thiab tsis pub dhau 3 hnub tom qab kev phais mob - 0.3 ml, nyob rau lub sijhawm tomqab (pib txij li 4 hnub) - 0.4 ml. Nrog lub cev qhov hnyav ntawm 71 txog 95 kg: hauv lub sijhawm preoperative thiab tsis pub dhau 3 hnub tom qab phais - 0.
4 ml, nyob rau lub sijhawm tom qab (pib txij li 4 hnub) - 0.6 ml.
Tom qab venography, nws tau txais kev tswj hwm txhua 12 teev rau 10 hnub, qhov koob tshuaj nyob ntawm lub cev qhov hnyav: nrog ntau txog 45 kg - 0.4 ml, 55 kg - 0.5 ml, 70 kg - 0.6 ml, 80 kg - 0.7 ml, 90 kg - 0.8 ml, 100 kg thiab ntau dua - 0.9 ml.
Hauv kev kho mob ntawm kev puas siab puas ntsws angina pectoris thiab myocardial infarction yam tsis muaj Q yoj, 0.6 ml (5700 IU antiXa) tau txais kev noj tshuaj 2 zaug hauv ib hnub.
Cov chaw muag tshuaj
Mechanism ntawm kev ua Calcium nadroparin yog cov muaj zog hnyav molecular heparin (LMWH) tau los ntawm depolymerization los ntawm tus qauv heparin.Nws yog glycosaminoglycan nrog qhov nruab nrab molecular hnyav ntawm kwv yees li 4300 daltons.
Nadroparin tso saib muaj peev xwm loj khi rau plasma protein nrog antithrombin III (AT III). Qhov khi no ua rau nrawm nrawm ntawm qhov Xa. uas yog vim muaj lub siab antithrombotic muaj peev xwm ntawm nadroparin. Lwm cov txheej txheem muab cov txiaj ntsig antithrombotic ntawm nadroparin.
suav nrog kev ua kom cov nqaij mos hloov dua siab tshiab (TFPI), kev ua haujlwm ntawm fibrinogenesis los ntawm kev tso tawm ntawm cov nqaij mos plasminogen los ntawm cov hlwb endothelial, thiab kev hloov kho ntawm cov ntshav rheology (txo cov ntshav viscosity thiab nce ntxiv hauv permeability ntawm platelet thiab granulocyte membranes).
Cov Tshuaj Hauv Tshuaj Nadroparin yog qhov tshwj xeeb los ntawm kev ua haujlwm ntau dua rau qhov sib piv ntawm XA, piv nrog kev ua haujlwm tiv thaiv tus yam ntxwv IIa. Nws muaj ob qho tib si tam sim ntawd thiab lub sijhawm ua haujlwm antithrombotic.
Muab piv rau cov tshuaj heparin tsis sib haum xeeb, nadroparin muaj cov nyhuv qis dua ntawm cov platelet muaj nuj nqi thiab ntawm kev sib sau ua ke thiab muaj cov nyhuv me ntawm thawj cov kab mob hemostasis.
Hauv kev txhaj tshuaj prophylactic, nws tsis ua rau lub suab txo qis hauv ntu thrombin lub sijhawm (APTT).
Nrog rau kev kho mob lub sijhawm lub sijhawm ua haujlwm siab tshaj plaws, APTT tuaj yeem txuas ntxiv kom tus nqi 1.4 npaug siab dua li tus qauv. Xws li lub caij nyoog ntev ua kom pom qhov seem antithrombotic ntawm cov calcium calcium nadroparin.
Cov Tshuaj Pharmacokinetics Cov cuab yeej pharmacokinetic tau txiav txim siab los ntawm cov kev hloov pauv ntawm qhov cuam tshuam anti-Xa yam kev ua haujlwm ntawm ntshav.
Tom qab tswj hwm subcutaneous, qhov siab tshaj tawm los tiv thaiv Xa cov haujlwm (C max) tau tiav tom qab 35 teev (T max).
Bioavailability Tom qab kev tswj hwm subcutaneous, nadroparin yog yuav luag yaim (li 88%).
Nrog kev tswj hwm kev ncaj qha, qhov siab tshaj plaws ntawm kev tiv thaiv Xa-ua tiav nyob hauv tsawg dua 10 feeb, ib nrab-lub neej (T½) yog li 2 teev.
Kev tiv thaiv kab mob Metabolism feem ntau tshwm sim hauv daim siab (desulfation, depolymerization).
Ib nrab-lub neej tom qab kev tswj hwm subcutaneous yog li 3.5 teev. Txawm li cas los xij, cov haujlwm tiv thaiv Xa-mob tseem muaj tsawg kawg 18 teev tom qab txhaj tshuaj nadroparin ntawm ib koob ntawm 1900 los tiv thaiv XA ME.
Cov pab pawg muaj kev pheej hmoo
Cov neeg laus cov neeg mob
Hauv cov neeg mob laus, vim tias qhov ua kom lub raum txo qis dua, kev tshem tawm nadroparin tuaj yeem qeeb. Kev raum tsis ua hauj lwm hauv cov neeg mob no yuav tsum muaj kev soj ntsuam thiab kev hloov tshuaj kom tsim nyog.
Cov neeg mob lub raum tsis zoo lub ntsws ua haujlwm hauv kev tshawb fawb txog kev kho mob ntawm pharmacokinetics ntawm nadroparin thaum muab tshuaj rau cov neeg mob raum tsis ua haujlwm ntawm qhov mob tsis zoo, ib qho kev sib txuam tau tsim los ntawm kev tshem tawm ntawm nadroparin thiab kev tshem ntawm creatinine.
Thaum muab piv rau cov txiaj ntsig tau nrog rau cov neeg tuaj yeem noj qab haus huv, nws tau pom tias AUC thiab ib nrab-lub neej tau nce mus txog 52-87%, thiab creatinine tshem tawm mus rau 47-64% ntawm qhov tseem ceeb. Txoj kev tshawb fawb kuj tseem pom qhov txawv ntawm cov tib neeg.
Hauv cov neeg mob uas mob raum tsis zoo, ib nrab ntawm lub neej ntawm nadroparin nrog kev coj noj coj ua tau nce mus txog 6 teev.
Cov txiaj ntsig ntawm txoj kev tshawb no pom tias nadroparin muaj me ntsis ntxiv tuaj yeem pom hauv cov neeg mob uas tsis tshua mob me me lossis mob raum tsis zoo (kev ua kom zoo yog tsim muaj ntau dua lossis sib npaug ntawm Som / min thiab qis dua 60 ml / min), yog li ntawd, koob tshuaj Fraxiparin yuav tsum raug txo 25% hauv cov neeg mob uas tau txais Fraxiparin rau kev kho mob ntawm thromboembolism, tsis khov kho angina pectoris / myocardial infarction tsis muaj Q yob. Fraxiparin yog sib kis hauv cov neeg mob uas mob raum tsis ua haujlwm, txhawm rau kho cov mob no. Hauv cov neeg mob uas mob raum tsis tshua mob pes tsawg lossis qis qis, kev siv Fraxiparin rau kev tiv thaiv ntawm thromboembolism, kev txuam nrog nadroparin tsis ntau tshaj qhov ntawd rau cov neeg mob uas lub raum tsis ua haujlwm, noj tshuaj rau ntawm Fraxiparin. Yog li, txo qhov koob tshuaj Fraxiparin noj rau lub hom phiaj prophylactic hauv pawg no ntawm cov neeg mob tsis tas yuav tsum. Hauv cov neeg mob uas mob raum tsis zoo uas tau txais prophylactic fraxiparin, qhov yuav txo qhov ntau npaum li 25% yog tsim nyog muab piv nrog cov koob tshuaj uas tau muab rau cov neeg mob uas muaj kev tsim tawm zoo.
Tsawg molecular hnyav heparin tau nkag mus rau hauv txoj hlab ntshav ntawm lub voj voos lim ntshav hauv qhov siab txaus kom tiv thaiv cov ntshav coagulation nyob rau hauv lub voj. Cov chaw muag tshuaj tsis hloov pauv hloov pauv, tshwj tsis yog kis ntawm kev noj tshuaj ntau dhau, thaum txoj kev tso tshuaj rau hauv cov ntshav ncig yuav ua rau muaj qhov nce ntawm anti-Xa yam ua rau cuam tshuam nrog cov theem kawg ntawm lub raum tsis ua haujlwm.
Fraxiparin analog
Kuv cov khoom muaj nqis (jana)
Puas muaj tej yam txawv ..
Cov ntxhais, puas muaj ib qho kev sib txawv ntawm Clexane thiab Fraxipain? Kuv tam sim no txhav Kleksan nrog tus kws kho mob poj niam 0.4 (nws tsis paub meej vim li cas tus kws kho mob poj niam tau tsa kho nws) ?? (mus rau hematologist hnub Tuesday 13) Kuv pib tham txog hloov mus rau 0.6.
Nag hmo kuv mus lwm 0.4, thiab tom qab ntawd ntau npaum li cas nws yuav raug nqi rau kuv 0.6 yog tias. Cov ntxhais ntawm 816 rubles, i.e. rau kaum ob, yuav tsum tau yob tawm hauv thaj tsam ntawm 10,000 rubles. Kuv tsis yog tus ntxhais muaj nyiaj lab thiab kuv tsis muaj ntawv luam ntawv, txawm li cas los xij, Kuv xav tias nws tsis nyob hauv txhua tus.
LCD muab cov lus piv txwv ntawm fraxiparin
Cov ntxhais uas txhaj tshuaj analogues ntawm fraxiparin thiab clexane rau kev xeeb tub? Cov tshuaj no yuav tsum tau muab rau kuv hauv LCD, tab sis lawv hais tias lawv tsis muaj thiab lawv xav sau tawm ib co tshuaj ntxiv, Kuv tsis muaj sijhawm los khaws lub npe rau hauv daim ntawv qhia (lawv tsis tau tshaj tawm).
Lawv hais tias nws zoo ib yam. Tab sis yog tias yog li ntawd, ces tus kws kho mob (tus kws kho mob tsis tau sau tshuaj rau ntawm LCD) yuav xub hais txog tag nrho cov tshuaj uas kuv tuaj yeem siv, thiab nws sau tsuas yog sau ntawv fraxiparin thiab clexane.
Analogs tuaj yeem muaj cov kev cuam tshuam zoo ...
NTSHAV DAWB HUV
Fraxiparin, Clexane, Wessel Douai cov lus qhia rau kev siv, nqi, analogues
Nyeem ntxiv ... Olga (Vova niam)
Hemopaxan raws li ib qho lus piav qhia ntawm Fraxiparin
Hauv kuv LCD, Kuv tau muab tshuaj rau Hemopaxan dawb, uas zoo li yog ib qho khoom noj ntawm Fraxiparin. Puas muaj leej twg hnov txog cov tshuaj no? Tiag tiag qhov analog? Lawv tawm tswv yim tias sim ntawm koj tus kheej qhov kev pheej hmoo thiab pheej hmoo.
Fraxiparin ntxim hlub creepy, qhia rau kuv nws hematologist li "hauv rooj plaub", kom paub tseeb tias oxygen mus rau tus menyuam khiav tawm yam tsis muaj teeb meem… ..Kuv tabtom xav sim, tab sis vim tias
Kuv tsis paub dab tsi txog cov tshuaj no - Kuv txiav txim siab los nug hauv kev sib tham ...
Kev Xeeb Tub Rog Txhua Lim Tiam
Peb yuav qhia koj cov dab neeg tiag ntawm peb cov niam tsev uas tau dhau los ntawm qhov no lossis dhau mus tam sim no!
Fraxiparin thiab tuam txhab
Kuv tsis tau ua qhov kev ntsuam xyuas tshwj xeeb, txhua qhov zoo ib yam uas kuv tau sau tseg rau fraxiparin. Raws li kev txheeb xyuas, lub platelet suav tau nce me ntsis. Kuv tsis tau mus ntsib hematologist thiab, hauv txoj ntsiab cai, tsis muaj txoj kev tuaj xyuas. Muaj ob peb nqe lus nug. Tus kws kho mob hais tias “yuav tsum” thiab txhua yam zoo li ntawd.
Tsis muaj dab tsi meej. Kuv hloov tsis tau tus kws kho mob thiab.
1) tam sim no muab tso rau qhov kawg ntawm cev xeeb tub? 2) yuav muaj dab tsi tshwm sim yog tias kuv tsis mus txhaj tshuaj rau ob peb hnub? Piv txwv li, yog tias tsis muaj tshuaj hauv ib lub tsev muag tshuaj 3) nws puas ua rau noj tshuaj rau hemostasiogram? Qhov twg kuv yuav nrog nws nyob, yog hais tias mus rau hematologist ...
Kuv yuav muag Zibor 3500! Moscow Tau cog lus tseg
Cov menyuam ntxhais, Kuv muag ib qho pev nquam ntawm clexane thiab fraksiparin. Nws mus ze kuv ntxiv, txawm hais tias nws tig los yuav nyuaj nrhiav. Tsho raug tag nrho lub cev xeeb tub !! Tsibor 3500 5 pcs rau 1000 r. Siv tau kom txog rau thaum 05.2016.
Kuv yuav thaum lub Yim Hli Ntuj ua ntej yug 10 pcs rau 3550 p. Kuv tuaj yeem muab cov corinfar yuav luag tag nrho thiab cov hlwv genipral ntxiv rau ntxiv. Zibor tom qab ua tiav txoj kev ua tiav, uas yog qhov kuv ntshaw txhua tus! Moscow Nastya. Xov Tooj 8-926-93-67-560.
Mus nqa los ntawm chaw nres tsheb metro Yuzhnaya rau hnub ua haujlwm ...
Sib tham txog koj lub ncauj lus hauv zej zog, tau txais kev xav ntawm cov neeg siv dag zog ntawm Babloglog
Mus rau hauv zej zog
Olga (Vovchik niam)
Ntshav los ntawm lub qhov ntswg tom qab ib chav kawm ntawm cov kev txhaj tshuaj kom nyias cov ntshav
Nag hmo yog qhov kawg txhaj 21 ntawm Gemapaksan, uas tau sau ntawv rau kuv los ntawm cov kws kho mob "rau txhua tus neeg tua hluav taws", qhov no yog qhov piv txwv ntawm Fraksiparin, nws cov ntsiab lus yog ntshav ntshav. Hemostasis amid ntawm kev txhaj tshuaj tau zoo heev, tab sis .... nag hmo thiab hnub no, qhov ntswg ntshav pib dheev pib.
Thiab tsis yog ob peb tee dej, tab sis tsuas yog ntws tawm! Thiab tsis tau tsum rau lub sijhawm ntev. Yog lawm kuv ntshai heev.
Puas yog kuv txuas rau qhov no rau ntawm Gemapaksan los? Puas muaj kev cia siab tias tom qab tshem tawm txoj kev txhaj tshuaj (Kuv yuav tsis ua nws hnub no) qhov kev txaj muag no yuav nres? Qhov no yeej tsis tau muaj dua los .......
Nyeem ntau tshaj ... Niam nyob rau hauv teb chaws Cuba
Kuv yuav lees txais ua khoom plig lossis pauv hauv tshuaj! Moscow!
Peb xav tau menopur (lossis nws analogues), tsav hauv cov koob txhaj tshuaj, cytrocide, orgalutran, rotted! Tshav kev lom zem (IVF), hmoov tsis, peb yeej tsis muaj paj daus, vim tias 1-3 embryos ib txwm muaj sia nyob, hloov tag nrho, yog li koj yuav tsum nkag mus siv cov lus qhia txhua zaus ib qho tshiab! Tej zaum yuav tsum muaj qee yam pauv hloov, Kuv tuaj yeem pom dab tsi kuv muaj los ntawm kuv cov tshuaj los txhawb kev xeeb tub (Utrozhestan, Clexane, Fraxiparin!? Yog tias ...
Kuv muab cov tshuaj phua tawm hauv cov txheej txheem
Kuv muab cov tshuaj txiav tawm tsis pub siv nyob rau hauv cov txheej txheem rau tus nqi me me ntawm Fraxiparin 0.3 1 p. URGENTLY kom txog rau thaum 06.2015! Clexane 0.8 ml 2 pcs txog rau thaum 01.2017 PASSED Analogue ntawm clexane edema tshuaj Anfibra (ntau yam) hauv ampoules ntawm 0.6 ml thiab 0.4 ml yuav muab rau cov uas xav tau cov nyiaj them rau txoj kev (coj ntawm no los ntawm Elena), tsis muaj txiaj ntsig, tshem tawm txoj hmoo zoo! Nkag mus rau Medvedkovo metro chaw nres tsheb
fraxiparin lossis cov tshuaj aspirin cardio ?!
Cov ntxhais, thov piav rau kuv, txwv tsis pub kuv lub taub hau rov sauv. Kuv tus kws kho mob hais tawm tias kev txhaj tshuaj fraxiparin (txhaj ib zaug txhua 5 hnub) raug hloov nrog tshuaj aspirin-cardio lossis cov tshuaj ntxiv rau hauv cov ntsiav tshuaj sau 100 mg thaum hmo ntuj txhua hnub.
Kuv tsis tuaj yeem nkag siab yog vim li cas? Tus poj niam nws tsis piav qhia. Hais tias tej yam zoo li ntawd muaj pes tsawg leeg ntawm fraxiparin nws tus kheej tau hloov pauv thiab qee zaus lawv ua rau cov kev coj ua, uas yog, lawv tsis ua kom ntshav nyias, tab sis ua rau cov ntshav txhaws. Zoo li tej yam tshiab hauv tshuaj.
Puas muaj tseeb tiag? Kuv coj tawm kuv tus tub ...
Anfiber siv clexane, leej twg txhaj?
Cov menyuam ntxhais uas nyob ntawm clexane lossis fraxiparin thiab cov tshuaj zoo sib xws qhia kuv. Kuv siv clexane txhua lub sijhawm, thiab niaj hnub no hauv ZhK lawv tau muab cov tshuaj Lavxias uas pheej yig dua ntawm cov tshuaj no, Anfibra, tib yam tshuaj muaj zog, thiab lwm yam. Leej twg ntsib Koj kev xav txog nws, lossis tej zaum hematologist xa nws mus rau lwm tus thiab?
Npaj tom qab eco, Ukraine
Muag / yuav Muag Muag utrozhestan, progina, kleksan, fragmentin, Kiev Nqe300 UAH. 05/18/2017 09:27 Thaj Chaw: Kiev (Kiev) Kuv yuav muag cov tshuaj seem: Utrozhestan 100mg siv tau mus txog 08/08 - 300 UAH muaj 4 pob.
Proginova 2mg tsim nyog txog 2020, muaj 2 pob ntawm 200 UAH txhua. Clexane 0.2ml siv tau txog txij 09.2018, muaj 20 koob txhaj - 60 UAH rau ib qho koob txhaj. Fragmin 2500me (analogue ntawm clexane thiab fraxiparin) siv tau mus txog 09.
2018, muaj 18 shrishchov- 70 UAH rau kev txhaj tshuaj Papaverine txhaj tshuaj yog qhov tsim nyog ...
Hais txog cov tshuaj kim. Kuv qhov kev mus ncig tom ntej rau LCD,
Tau txais cov lus qhia los ntawm Lub Tsev Haujlwm rau ZhK tias kuv xav tau tshuaj, Kuv tau mus rau ZhK. Lub Ib Hlis, lawv tau sau cov tshuaj ntawm Fraxiparin Anfibra. Tab sis hloov ntawm 0.6 ml kuv xav tau, lawv tau muab tsuas yog 0.4.
Thaum kuv tuaj rau kev tiv thaiv thiab tus kws kho mob pom kuv tus mob hemostasis, nws tam sim ntawd tau hais tias 0.6 xav tau. Lub Ob Hlis, raws li lub taub hau. tus ceg tau txiav txim siab rau 30 ampoules ntawm 0.6 txhua rau kuv Tus kws kho mob tau muab tshuaj rau 30 ampoules Tab sis hauv kev muaj tiag nws muab tawm tias tsuas yog 20 raug xaj.
Lawv kuj tsis xav muab. Mus, lawv hais tias, sau cov ntawv qhia rov qab. Kuv yuav tsum nce mus rau hauv pem teb 3 ...
Innogep, fraksiparin, clexane - nws puas tuaj yeem hloov pauv mus rau lwm tus?
Nyob zoo hais mav! Ib zaug ntxiv yam tsis muaj koj kev pab thiab kev paub hauv ib txoj kev twg. Pab tswv yim! Kuv muaj mob thrombophilia thiab vim tias qhov no, Kuv yuav tsum tau txhaj tshuaj ntawm cov muaj lwg me me nyhav heparin thoob plaws hauv kuv cev xeeb tub. Tam sim no (15 lub lis piam) Kuv xaj Innogep 4500 - hauv tebchaws Greece.
Tab sis nws yog lub sijhawm rov qab mus rau Lavxias, thiab tsis muaj ib yam tshuaj no (Kuv xav tias vim kev rau txim) thiab nws cov tshuaj noj nrog cov tshuaj active tinzaparin sodium. Tab sis nyob hauv Russia muaj Fraksiparin (Kuv tau txhaj nws txhua kuv thawj zaug cev xeeb tub) thiab Kleksan. Tab sis muaj lwm yam tshuaj lom.
Ib ntawm koj thaum cev xeeb tub ...
Kuv kev txhawb nqa tom qab cryoprotection
Fraxiparin: cov lus qhia, txhais ua, cov lus sib dhos, cov cim, cov tsis sib xws, cov chaw nyob thiab cov koob tshuaj
Calcium Nadroparin * (Nadroparin calcium *) Anticoagulants
Fraxiparin 9500me / ml 0.3ml n10 koob txhaj tshuaj | Aspen Notre Dame de Bondeville / Nanolek, LLC | 2472.00 |
Fraxiparin 9500me / ml 0.4ml n10 koob txhaj tshuaj | Aspen Notre Dame de Bondeville / Nanolek, LLC | 2922.00 |
Fraxiparin 9500me / ml 0.6ml n10 koob txhaj tshuaj | Aspen Notre Dame de Bondeville / Nanolek, LLC | 3779.00 |
Fraxiparin 9500me / ml 0.8ml n10 koob txhaj tshuaj | Aspen Notre Dame de Bondeville / Nanolek, LLC | 4992.00 |
020 (Kev qhia ua anticoagulant ncaj qha - tsis tshua muaj lub cev hnyav molecular heparin)
Qhov kev daws rau sc tswj hwm yog pob tshab, me ntsis opalescent, tsis muaj xim lossis lub teeb daj hauv xim.
1 rab koob tshuaj | |
nadroparin calcium | 2850 IU Anti-Ha |
Cov muaj mob: cov kua calcium hydroxide tov los yog dilute hydrochloric acid (txog pH 5.0-7.5), d / i dej (nce txog 0.3 ml).
0.3 ml - ib leeg koob tshuaj (2) - hlwv (1) - pob ntawv los qhia; 0.3 ml - ib leeg koob (2) - hlwv (5) - pob khoom los qhia.
Qhov kev daws rau sc tswj hwm yog pob tshab, me ntsis opalescent, tsis muaj xim lossis lub teeb daj hauv xim.
1 rab koob tshuaj | |
nadroparin calcium | 3800 IU Anti-Ha |
Cov neeg muaj mob: cov kua calcium hydroxide tov los yog dilute hydrochloric acid (txog pH 5.0-7.5), d / i dej (nce txog 0.4 ml).
0.4 ml - ib leeg koob txhaj tshuaj (2) - hlwv (1) - pob ntawv los qhia 0.4 ml - ib leeg koob tshuaj (2) - hlwv (5) - pob khoom los ntawm cardboard.
Qhov kev daws rau sc tswj hwm yog pob tshab, me ntsis opalescent, tsis muaj xim lossis lub teeb daj hauv xim.
1 rab koob tshuaj | |
nadroparin calcium | 5700 IU Anti-Ha |
Cov neeg muaj mob: cov kua calcium hydroxide tov lossis dilute hydrochloric acid (txog pH 5.0-7.5), d / i dej (nce txog 0.6 ml).
0.6 ml - ib leeg koob tshuaj (2) - hlwv (1) - pob ntawv los qhia; 0.6 ml - ib leeg koob tshuaj (2) - hlwv (5) - pob khoom los ntawm cardboard.
Qhov kev daws rau sc tswj hwm yog pob tshab, me ntsis opalescent, tsis muaj xim lossis lub teeb daj hauv xim.
1 rab koob tshuaj | |
nadroparin calcium | 7600 IU Anti-Ha |
Cov neeg muaj mob: cov kua calcium hydroxide tov los yog dilute hydrochloric acid (txog pH 5.0-7.5), d / i dej (nce txog 0.8 ml).
0.8 ml - ib leeg koob tshuaj (2) - hlwv (1) - pob ntawv los qhia; 0.8 ml - ib leeg koob (2) - hlwv (5) - pob khoom los qhia.
Qhov kev daws rau sc tswj hwm yog pob tshab, me ntsis opalescent, tsis muaj xim lossis lub teeb daj hauv xim.
1 rab koob tshuaj | |
nadroparin calcium | 9500 IU Anti-Ha |
Cov neeg muaj mob: cov kua calcium hydroxide tov los yog dilute hydrochloric acid (txog pH 5.0-7.5), d / i dej (txog 1 ml).
1 ml - ib leeg koob tshuaj (2) - hlwv (1) - pob ntawv los qhia 1 ml - ib leeg koob tshuaj (2) - hlwv (5) - pob khoom los qhia.
Fraxiparin analogues
LUS QHIA ntawm kev siv tshuaj Fraxiparin
Pharmacological kev txiav txim
Cov tshuaj calcium nadroparin (tshuaj sib xyaw ua ke ntawm Fraxiparin) yog qhov muaj zog tsawg cov heparin los ntawm heparin los ntawm depolymerization nyob rau hauv cov mob tshwj xeeb. Angi-Xa kev ua haujlwm (i.e., antiplatelet / platelet adhesion / kev ua si) ntawm cov tshuaj yog tshaj tawm ntau dua li nws cov nyhuv ntawm kev ua haujlwm ib feem platelet thrombocyte lub sijhawm (ib qho kev ntsuas ntawm cov ntshav coagulation tus nqi), uas paub qhov txawv nadroparin calcium los ntawm tsis sib luag qauv heparin. Yog li, cov tshuaj • muaj cov haujlwm ua antithrombotic (tiv thaiv kom tsis txhob tuaj ntshav), muaj qhov cuam tshuam sai thiab kav ntev.
Kev ntsuas rau siv
Kev siv Fraxiparin yog kev pom zoo rau:
• kev tiv thaiv ntawm cov teeb meem thromboembolic (kev tsim cov ntshav txhaws nyob rau hauv cov leeg) tom qab kev phais mob, ob qho tib si kev phais mob orthopedic, hauv cov neeg mob uas tsis yog phais mob uas muaj kev pheej hmoo loj ntawm kev mob txhim kho (mob ua pa nyuaj thiab / lossis ua pa nyuaj, lub plawv tsis ua haujlwm), cov neeg mob kho nyob hauv cov tsev saib xyuas mob hnyav, • tiv thaiv kev coagulation ntshav thaum hemodialysis, • kev kho cov teeb meem thromboembolic, • kho tsis ruaj khov iliac angina pectoris thiab myocardial infarction tsis muaj Q yoj ntawm ECG.
Txoj kev ntawm daim ntawv thov
Fraxiparin yog npaj rau subcutaneous thiab
kev tswj hwm ntawm cov leeg. Tsis txhob siv Fraxiparin intramuscularly. Nrog kev qhia ntawm Fraxiparin, nws tsis tuaj yeem tov nrog lwm cov tshuaj tiv thaiv. Cov koob tshuaj pom zoo li niaj zaus yog 0.3 ml ntawm fraxiparin ib hnub ib subcutaneously tsawg kawg 7 hnub. Nyob rau hauv txhua rooj plaub, kev tiv thaiv yuav tsum tau ua thaum lub sijhawm muaj kev pheej hmoo.
Thawj koob tshuaj tau muab 2 rau 4 teev ua ntej kev phais mob Orthopedic phais. Thawj koob tshuaj Fraxiparin raug siv 12 teev ua ntej kev ua haujlwm thiab 12 teev tom qab nws. Kev siv cov tshuaj no txuas ntxiv rau tsawg kawg 10 hnub. Nyob rau hauv txhua rooj plaub, kev tiv thaiv yuav tsum tau ua thaum lub sijhawm muaj kev pheej hmoo.