Levemir lossis Lantus? > Cov tshuaj insulin

Cov tshuaj twg zoo dua: Levemir lossis Lantus, feem ntau ua rau cov neeg mob uas muaj ntshav qab zib ua kom zoo siab. Tag nrho ob qho chaw muag tshuaj yog ib daim ntawv ntau npaum ntawm cov tshuaj insal hauv basal thiab yog tus cwj pwm los ntawm lub sijhawm ntev. Yog li, thiaj li tawm ib qho zoo tshaj plaws rau koj tus kheej, koj yuav tsum paub txog koj tus kheej nrog lawv ib tus zuj zus, them nyiaj tshwj xeeb rau txoj ntsiab cai ntawm kev ua haujlwm ntawm cov tshuaj, contraindications thiab tsis zoo uas yuav tshwm sim thaum kho nrog Lantus lossis Levemir.

TSEEM CEEB YUAV TSUM! Txawm tias cov ntshav qab zib siab tshaj plaws tuaj yeem kho tau hauv tsev, tsis tas yuav phais lossis tsev kho mob. Tsuas nyeem dab tsi Marina Vladimirovna hais. nyeem cov lus pom zoo.

Dab tsi yog qhov sib txawv ntawm Lantus molecule thiab insulin tib neeg

Insulin Lantus (Glargin) yog tsim tawm los ntawm kev siv cov khoom siv tshuaj tua hluav taws xob. Nws tau los ntawm kev rov ua kom tiav ntawm Escherichia coli Escherichia coli kab mob DNA (K12 hom). Hauv cov tshuaj insulin molecule, Glargin hloov asparagine nrog glycine ntawm txoj haujlwm 21 ntawm txoj saw A, thiab ob lub lwg ntawm arginine ntawm txoj haujlwm 30 ntawm cov saw B tau ntxiv. Qhov sib ntxiv ntawm ob lub arginine lwg me me rau C-terminus ntawm B-saw hloov pauv isoelectric kis los ntawm pH 5.4 rau 6.7.

Lantus insulin molecule - ua kom yooj yim dua nrog me ntsis acidic pH. Nyob rau tib lub sijhawm, nws yog qhov tsawg dua li ntawm tib neeg cov tshuaj insulin, soluble ntawm physiological pH ntawm subcutaneous ntaub so ntswg. Hloov A21 asparagine nrog glycine yog isoelectrically nruab nrab. Nws yog tsim los muab cov txiaj ntsig kev tshwm sim ntawm tib neeg insulin nrog kev ruaj khov. Glulin insulin yog tsim nyob rau hauv cov kua qaub pH ntawm 4.0, thiab yog li ntawd nws yog txwv tsis pub sib xyaw nrog insulin tsim ntawm qhov nruab nrab pH, thiab tseem mus rau yaj nws nrog kua ntsev lossis dej distilled.

Insulin Lantus (Glargin) muaj lub caij nyoog ntev vim qhov tseeb tias nws muaj tus nqi tshwj xeeb qis pH. Kev hloov pauv pH ua rau qhov tseeb tias hom insulin yaj tsawg dua nyob rau ntawm physiological pH ntawm cov nqaij mos subcutaneous. Lantus (Glargin) yog cov tshuaj ntshiab, ntshiab. Tom qab subcutaneous tswj hwm cov kua dej, nws tsim cov microrecipients nyob rau hauv nruab nrab lub cev muaj sia pH ntawm qhov chaw subcutaneous. Insulin Lantus yuav tsum tsis txhob tov nrog dej qab ntsev lossis dej rau kev txhaj tshuaj, vim tias vim qhov no, nws tus pH yuav mus rau qhov qub, thiab lub tshuab ntawm kev ua haujlwm ntev ntawm insulin yuav cuam tshuam. Qhov zoo ntawm Levemir yog tias nws zoo li yuav tsum tau diluted li sai tau, txawm hais tias qhov no tsis tau tso cai pom zoo, nyeem ntxiv rau hauv qab no.

Insulin Levemir (Detemir) yog lwm qhov ntawm cov insulin ntev, uas yog kev sib tw rau Lantus, uas tau tsim los ntawm Novo Nordisk. Piv rau tib neeg cov kua dej, cov amino acid nyob hauv Levemir molecule raug tshem tawm ntawm txoj haujlwm 30 ntawm txoj saw B. Hloov chaw, qhov seem ntawm cov roj fatty acid, myristic acid, uas muaj 14 cov pa roj carbon atoms, txuas rau cov amino acid lysine ntawm txoj haujlwm 29 ntawm B txoj saw. Vim qhov no, 98-99% ntawm cov tshuaj insulin Levemir hauv cov ntshav tom qab txhaj khi rau albumin.

Levemir yog maj mam nqus los ntawm thaj chaw txhaj tshuaj thiab muaj lub sijhawm ntev. Nws qhov ua kom qeeb yog ua tiav vim qhov tseeb tias cov tshuaj insulin nkag mus rau hauv cov hlab ntshav qeeb dua, thiab kuj vim tias cov molecules ntawm insulin analogue nkag mus rau cov phiaj hlwb qeeb qeeb. Txij li hom insulin no tsis muaj qhov tshaj tawm los ntawm lub luag haujlwm, qhov kev pheej hmoo ntawm ntshav qog ntshav qis yog txo los ntawm 69%, thiab hmo ntuj hypoglycemia - los ntawm 46%. Qhov no tau qhia los ntawm kev tshawb pom 2 xyoo hauv cov neeg mob ntshav qab zib hom 1.

Qhov twg ntev insulin yog qhov zoo dua - Lantus lossis Levemir?

Lantus thiab Levemir yog qhov ua yeeb yam ntev ntev rau cov tshuaj insulin, qhov tseeb tshaj plaws hauv kev kho mob ntshav qab zib nrog cov tshuaj insulin. Lawv muaj txiaj ntsig zoo nyob rau hauv tias lawv muaj cov ntawv txiav txim siab ruaj khov uas tsis muaj peaks - daim duab plasma concentration daim duab ntawm cov hom insulin muaj hom "dav hlau nthwv dej". Nws luam tawm qhov ib txwm muaj sia hauv kev sib xyaw ntawm basal (keeb kwm yav dhau) insulin.

Lantus thiab Detemir yog hom ruaj khov thiab kwv yees li ntawm hom tshuaj insulin. Lawv coj yuav luag tus kheej hauv cov neeg mob sib txawv, nrog rau hnub sib txawv ntawm tib tus neeg mob. Tam sim no tus kab mob ntshav qab zib tsis tas yuav sib tov txhua yam ua ntej muab nws tus kheej rau kev txhaj tshuaj ntawm cov insulin ntev, tab sis ua ntej tias muaj ntau dua fuss rau protafan nrog "qhov nruab nrab" insulin.

Ntawm Lub Pob Lantus nws tau sau tseg tias txhua qhov insulin yuav tsum siv nyob rau hauv 4 lub lis piam lossis 30 hnub tom qab cov ntawv tau luam tawm. Levemir muaj lub txee kev ua haujlwm ntawm 1.5 lub sijhawm ntev dua, mus txog 6 lub limtiam, thiab tsis raug cai mus txog 8 lub limtiam. Yog tias koj nyob rau qhov kev noj haus uas tsis muaj carbohydrate rau hom 1 lossis hom 2 mob ntshav qab zib, koj yuav xav tau noj tsawg kawg txhua hnub ntawm cov insulin txuas ntxiv. Yog li no, Levemir yuav yooj yim dua.

Kuj tseem muaj cov lus qhia (tsis yog qhov tseeb!) Tias Lantus ua rau muaj kev pheej hmoo ntawm mob qog nqaij hlav ntau dua li lwm hom insulin. Qhov laj thawj muaj peev xwm yog tias Lantus muaj qhov kev sib txuam siab rau kev loj hlob hormone receptors uas nyob rau saum npoo ntawm cov qog nqaij hlav cancer. Cov ntaub ntawv hais txog Lantus kev koom tes hauv kev mob qog noj ntshav tsis tau muaj pov thawj, cov kev tshawb fawb tshawb pom yog qhov sib txawv. Tab sis nyob rau hauv txhua rooj plaub, Levemir yog qhov pheej yig dua thiab hauv kev coj ua tsis muaj qhov phem dua. Qhov txiaj ntsig tseem ceeb yog tias Lantus yuav tsum tsis txhob xeb txhua, thiab Levemir - yog tias ua tau, txawm tias tsis raws cai. Tsis tas li, tom qab pib siv, Levemir khaws cia ntev dua li Lantus.

Coob tus neeg mob ntshav qab zib thiab endocrinologist ntseeg tias yog tias txhaj ntau dua, yog li txhaj ib koob Lantus ib hnub yog qhov txaus. Nyob rau hauv txhua kis, levemir yuav tsum tau txhaj ob zaug ib hnub, thiab yog li ntawd, nrog cov koob tshuaj loj loj, nws yooj yim dua yog qhov raug kho nrog Lantus. Tab sis yog tias koj tab tom ua raws li hom kho mob ntshav qab zib hom 1 lossis hom kho mob ntshav qab zib hom 2, cov txuas uas tau muab rau hauv qab no, tom qab ntawd koj yuav tsis xav tau koob tshuaj txuas ntxiv ntawm cov tshuaj insulin txhua lub sijhawm. Peb xyaum tsis siv cov koob tshuaj loj no uas lawv txuas ntxiv ua haujlwm ib hnub nkaus, tsuas yog cov neeg mob ntshav qab zib hom 2 uas muaj rog rog ntau dhau. Vim tias tsuas yog tus txheej txheem ntawm cov khoom thauj me me tso cai rau koj kom ua tiav kev tswj hwm ntshav qab zib hauv hom 1 thiab ntshav qab zib hom 2.

Peb tswj cov ntshav qab zib ntawm 4.6 ± 0.6 mmol / L, zoo li cov neeg noj qab haus huv, 24 teev nyob rau ib hnub, nrog kev hloov pauv me ntsis ua ntej thiab tom qab noj mov. Txhawm rau kom ua tiav lub hom phiaj no, koj yuav tsum tau txhaj tshuaj ntxiv nyob rau hauv cov koob tshuaj me ob zaug ib hnub. Yog hais tias mob ntshav qab zib tau kho nrog kev txhaj tshuaj me me ntawm kev tiv thaiv kab mob ntev, tom qab lub sijhawm ntawm Lantus thiab Levemir yuav luag zoo li qub. Nyob rau tib lub sijhawm, qhov zoo ntawm Levemir, uas peb tau piav qhia saum toj no, yuav tshwm sim lawv tus kheej.

Vim li cas nws yog qhov tsis tsim nyog siv NPH-insulin (protafan)

Txog rau lub sijhawm xyoo 1990, cov hom tshuaj insulin luv luv tau huv raws li dej, thiab txhua tus so tau huab, opaque. Cov tshuaj insulin yuav dhau los vim muaj qhov sib ntxiv ntawm cov khoom siv uas ua rau cov lus tshwj xeeb uas maj mam yaj hauv qab daim tawv nqaij ntawm ib tug neeg. Txog rau hnub no, tsuas yog ib hom tshuaj insulin tau nyob twj ywm raws caij nyoog - qhov nruab nrab ncua sij hawm ntawm qhov kev txiav txim, uas hu ua NPH-insulin, nws tseem yog protafan. NPH sawv cev rau "Hagedorn's Neutral Protamine," uas yog protein ntawm cov tsiaj keeb kwm.

Hmoov tsis zoo, NPH-insulin tuaj yeem txhawb lub zog tiv thaiv kab mob los tsim cov tshuaj tiv thaiv rau cov tshuaj insulin. Cov tshuaj tua kab mob no tsis ua kom puas, tab sis khi ib ntus ntawm cov insulin thiab ua rau nws tsis voos. Tom qab ntawd qhov kev khi no cov kab mob dheev dhau los ua neeg nquag thaum nws tsis xav tau lawm. Cov nyhuv no yog heev zog. Rau cov ntshav qab zib zoo tib yam, qhov sib txawv ntawm cov piam thaj ntawm ± 2-3 mmol / L yog qhov kev txhawj xeeb me ntsis, thiab lawv tsis pom nws. Peb sim tswj kev ua kom zoo rau cov ntshav qab zib, xws li 4.6 ± 0.6 mmol / l ua ntej thiab tom qab noj mov. Txhawm rau ua qhov no, peb ua txoj haujlwm kho mob ntshav qab zib hom 1 lossis hom kho ntshav qab zib hom 2. Hauv peb qhov xwm txheej, qhov tsis txaus ntseeg ntawm kev sib txuas nruab nrab insulin yuav pom tau thiab lwj daim duab.

Muaj lwm qhov teeb meem nrog tus neeg nruab nrab tiv thaiv Hagedorn. Angiography yog kev soj ntsuam ntawm cov hlab ntshav uas pub lub siab kom pom tias lawv muaj kev cuam tshuam li cas los ntawm atherosclerosis. Nov yog ib qho kev siv tshuaj los khomob. Ua ntej ua nws, tus neeg mob tau raug txhaj tshuaj ntawm heparin. Qhov no yog ib qho anticoagulant uas tiv thaiv platelets los txhaws ua ke thiab thaiv cov hlab ntsha nrog cov ntshav cov ntshav. Tom qab cov txheej txheem tiav, ua ib qho kev txhaj tshuaj ntxiv - NPH raug tswj hwm "thim tawm" heparin. Hauv feem pua me me ntawm cov tib neeg uas tau raug kho nrog protafan insulin, kev tsis haum tshuaj muaj tshwm sim nyob rau tam sim no, uas tuaj yeem ua rau tuag taus.

Qhov xaus yog tias yog tias nws tuaj yeem siv qee lwm yam hloov ntawm NPH-insulin, ces nws yog qhov zoo dua los ua qhov no. Raws li txoj cai, cov mob ntshav qab zib tau hloov pauv los ntawm NPH-insulin mus rau kev ua yeeb yam txuas ntxiv insulin analogues Levemir lossis Lantus. Ntxiv mus, lawv tseem qhia pom tias muaj txiaj ntsig zoo tshaj plaws ntawm kev tswj ntshav qab zib.

Qhov tsuas yog qhov kev siv ntawm NPH-insulin tseem tsim nyog niaj hnub no nyob hauv Asmeskas (!) Cov menyuam me uas muaj ntshav qab zib hom 1. Lawv xav tau cov tshuaj insulin tsawg kawg ntawm kev kho mob. Cov koob tshuaj no yog ib qho me me uas yuav tsum muaj cov tshuaj insulin. Hauv tebchaws United States, qhov no yog ua tiav siv cov peev txheej insulin dilution dlaws muab los ntawm cov tuam ntxhab dawb. Txawm li cas los xij, rau insulin analogues ntawm lub sijhawm ua haujlwm ntev, xws li kev daws teeb meem tsis muaj. Yog li no, Dr. Bernstein raug yuam kom sau ntawv txhaj tshuaj ntawm NPH-insulin, uas tuaj yeem raug 3-4 zaug ib hnub, rau nws cov neeg mob hluas.

Hauv cov teb chaws hais lus Lavxias, hom kev daws teeb meem rau insulin dilution tsis muaj nyob rau nruab hnub nrog hluav taws, rau ib qho nyiaj, txhua qhov ntau ntxiv pub dawb. Yog li, tib neeg txhaws insulin los ntawm kev yuav khoom saline lossis dej rau kev txhaj tshuaj hauv cov khw muag tshuaj. Thiab nws zoo li tias txoj kev no ntau dua los sis tsawg dua kev ua haujlwm, kev txiav txim los ntawm kev txheeb xyuas cov ntsiab lus ntshav qab zib. Nyob rau hauv txoj kev no, Levemir (tab sis tsis yog Lantus!) Txuas ntxiv insulin yog diluted. Yog tias koj siv NPH-insulin rau tus menyuam, tom qab ntawd koj yuav tsum txhaws nws nrog cov kua ntsev tib yam li Levemir. Nws yuav tsum tau yug los hauv lub siab tias Levemir ua tau zoo dua thiab nws tsis tsim nyog los laim nws. Nyeem ntxiv hauv kab lus “Yuav ua li cas txhawm rau tshuaj insulin kom raug txhaj tshuaj qis”

Yuav ua li cas ua kom qab zib ua tshais thaum sawv ntxov nyob rau ntawm lub plab khoob yuav li qub

Piv txwv tias koj tab tom noj ntau tshaj plaws cov tshuaj kom zoo rau hom 2 ntshav qab zib thaum hmo ntuj. Dua li ntawm qhov no, koj cov ntshav qab zib thaum sawv ntxov nyob ntawm lub plab khoob yog qhov siab dua li ib txwm, thiab nws feem ntau nce ib hmos. Qhov no txhais tau tias koj yuav tsum tau txhaj tshuaj txuas ntxiv thaum hmo ntuj. Txawm li cas los xij, ua ntej sau ntawv txhaj tshuaj li no, koj yuav tsum paub tseeb tias cov ntshav qab zib tau noj hmo 5 teev ua ntej mus pw. Yog tias cov piam thaj hauv ntshav nce siab thaum hmo ntuj vim qhov tseeb hais tias tus neeg mob ntshav qab zib muaj noj hmo lig, tom qab ntawd txuas insulin thaum tsaus ntuj yuav tsis pab. Nco ntsoov tias yuav tsim ib txoj kev noj qab haus huv thaum muaj noj hmo ua ntej. Sau ib qho kev ceeb toom rau koj lub xov tooj ntawm tes thaum 5.30 teev tsaus ntuj tias nws yog sijhawm los noj hmo, thiab muaj noj hmo thaum 6 teev tsaus ntuj-6.30 p.m. Tom qab noj hmo tag rau hnub tom qab, koj yuav zoo siab noj zaub mov protein rau pluas tshais.

Cov hom tshuaj insulin txuas ntxiv yog Lantus thiab Levemir. Saum toj no hauv tsab xov xwm no peb tau tham hauv kev nthuav dav seb lawv sib txawv li cas thiab ib qho twg zoo siv. Cia peb pom tias kev txhaj tshuaj txuas ntxiv li cas thaum hmo ntuj ua haujlwm. Koj yuav tsum paub tias daim siab yog ua haujlwm tshwj xeeb hauv kev ua kom muaj cov tshuaj insulin thaum sawv ntxov, ua ntej yuav sawv. Nov hu uas thaum sawv ntxov kaj ntug tshwm simCov. Nws yog nws leej twg ua rau muaj ntshav qab zib cov ntshav thaum sawv ntxov ntawm lub plab khoob. Tsis muaj leej twg paub txog nws cov laj thawj. Txawm li cas los xij, nws tuaj yeem tswj tau zoo yog tias koj xav ua kom tau qab zib li qub thaum sawv ntxov ntawm lub plab khoob. Nyeem ntxiv hauv kev nthuav dav "Phenomenon ntawm Tag kis Sawv ntxov thiab Yuav Tswj Nws Li Cas."

Vim tias qhov tshwm sim thaum sawv ntxov ntxov, qhov txhaj tshuaj insulin ntev dua thaum hmo ntuj pom zoo kom tsis pub dhau 8,5 teev ua ntej koj sawv thaum sawv ntxov. Cov txiaj ntsig ntawm kev txhaj tshuaj ntawm cov tshuaj insulin ntev ntev thaum hmo ntuj tau qaug zog heev 9 teev tom qab txhaj tshuaj. Yog tias koj ua raws li cov zaub mov tsis muaj carbohydrate rau cov ntshav qab zib, tom qab ntawd txhua yam tshuaj insulin, suav nrog insulin txuas ntxiv thaum hmo ntuj, yuav tsum muaj tsawg. Hauv cov xwm txheej zoo li no, feem ntau muaj txiaj ntsig ntawm kev txhaj tshuaj yav tsaus ntuj ntawm Levemir lossis Lantus nres ua ntej tsaus ntuj. Txawm hais tias cov tuam ntxhab hais tias qhov kev txiav txim ntawm cov hom insulin no kav ntev dua.

Yog tias koj qhov kev txhaj tshuaj thaum tsaus ntuj ntawm cov tshuaj insulin txuas ntxiv ua haujlwm txhua hmo thiab txawm tias yav sawv ntxov, nws txhais tau tias koj tau txhaj ntau dhau, thiab ib tag hmo cov suab thaj poob qis dua qhov qub. Ntawm qhov zoo tshaj plaws, yuav muaj kev npau suav phem, thiab ntawm qhov phem tshaj, muaj ntshav qab zib ntau. Koj yuav tsum teeb tsa lub tswb ntsig kom sawv tom qab 4 teev, thaum ib tag hmo, thiab ntsuas koj cov ntshav qab zib nrog ib glucometer. Yog tias nws qis dua 3.5 mmol / L, tom qab ntawd faib cov koob tshuaj ncua sij hawm yav tsaus ntuj rau hauv ob ntu. Caw ib qho ntawm cov seem tsis sai, tab sis tom qab 4 teev.

Qhov koj tsis tas yuav ua:

Tsa cov koob tshuaj yav tsaus ntuj ntawm cov tshuaj insulin kom zoo zoo, tsis txhob maj nrog nws. Vim tias yog tias nws lub siab dhau, tom qab ntawd thaum hmo ntuj nws yuav muaj ntshav qab zib nyob hauv npau suav phem. Thaum sawv ntxov, qab zib reflexively sawv mus rau ntau ntau uas nws "qaws dua". Qhov no hu ua Somoji phenomenon.
Ntxiv mus, tsis txhob tsa koj sawv ntxov noj Lantus, Levemir lossis Protafan. Qhov no yuav tsis pab kom muaj suab thaj qis yog tias nws tsa rau hauv lub plab khoob.
Tsis txhob siv 1 txhaj tshuaj ntawm Lantus rau 24 teev. Nws yog qhov yuav tsum tau pleev roj Lantus tsawg kawg ob zaug hauv ib hnub, thiab nyiam dua 3 zaug - thaum tsaus ntuj, tom qab ntawd ntxiv thaum 1-3 teev sawv ntxov thiab sawv ntxov lossis tav su.

Peb taw qhia ib zaug ntxiv: yog tias cov koob tshuaj ntev ntawm cov insulin ntau dua thaum hmo ntuj, tom qab ntawd kev yoo mov yuav tsis thim rau tag kis sawv ntxov, tab sis nce ntxiv.

Txhawm rau faib cov koob tshuaj yav tsaus ntuj ntawm cov tshuaj insulin txuas mus rau ob ntu, ib qho yog cov txhaj rau hauv nruab nrab ntawm qhov tsaus ntuj, yog qhov tseeb heev. Nrog rau cov kev cai no, tag nrho cov koob tshuaj thaum yav tsaus ntuj ntawm cov tshuaj insulin tuaj yeem txo los ntawm 10-15%. Nws kuj tseem yog txoj hauv kev zoo tshaj plaws los tswj thaum sawv ntxov thaum sawv ntxov thiab muaj ntshav qab zib thaum sawv ntxov nyob rau ntawm lub plab khoob. Kev txhaj tshuaj rau hmo ntuj yuav ua rau muaj qhov tsawg kawg ntawm kev tsis xis nyob thaum koj tau siv nrog lawv. Nyeem yuav ua li cas tau txhaj tshuaj insulin. Thaum ib tag hmo, koj tuaj yeem hno cov koob tshuaj tiv thaiv ntev tshaj plaws nyob hauv lub xeev ib nrab tsis nco qab lawm yog tias koj npaj txhua yam rau nws thaum yav tsaus ntuj thiab tom qab ntawd tam sim ntawd poob tsaug zog dua.

Yuav ua li cas los laij cov pib txhaj tshuaj ncua sij hawm thaum tsaus ntuj

Peb lub hom phiaj kawg yog kom xaiv cov koob tshuaj xws li Lantus, Levemir, lossis Protafan kom cov khoom qab zib sai sai yog nyob rau ntawm 4.6 ± 0.6 mmol / L. Nws yog qhov tshwj xeeb tshaj yog nyuaj rau normalize qab zib thaum sawv ntxov ntawm lub plab khoob, tab sis cov teeb meem no tseem daws tau yog tias koj sim. Yuav daws nws li tau piav qhia saum toj no.

Txhua tus neeg mob uas muaj ntshav qab zib hom 1 xav tau cov tshuaj insulin txuas ntxiv thaum hmo ntuj thiab yav sawv ntxov, nrog rau kev txhaj tshuaj sai sai ua ntej noj mov. Nws hloov tawm 5-6 zaug ib hnub twg. Hauv cov neeg mob uas muaj ntshav qab zib hom 2, cov xwm txheej yooj yim dua. Tej zaum lawv yuav tsum tau txhaj tshuaj tsawg dua. Tshwj xeeb tshaj yog yog hais tias tus neeg mob ua raws kev noj haus nrog cov zaub mov uas tsis muaj carbohydrate thiab tsis tub nkeeg kom ua si nrog kev lom zem. Cov neeg muaj ntshav qab zib hom 1 tseem qhia kom hloov mus rau qhov kev noj haus cov zaub mov kom qis. Yog tsis muaj qhov no, koj yuav tsis tuaj yeem tswj hwm cov piam thaj kom zoo, txawm hais tias koj ua tib zoo suav cov tshuaj insulin ntau npaum li cas.

Ua ntej tshaj plaws, peb ntsuas ntsuas qab zib nrog glucometer 10-12 zaug hauv ib hnub rau 3-7 hnub kom nkag siab tias nws coj li cas. Qhov no yuav qhia peb txog lub sijhawm koj xav tau txhaj insulin. Yog tias txoj haujlwm ntawm cov roj ntsha beta ntawm cov txiav ua tiav nrog qee cov khaws cia, ces tej zaum nws yuav muaj peev xwm mus txhaj nws tsuas yog thaum hmo ntuj lossis qee lub sijhawm noj mov. Yog tias tus neeg mob uas muaj ntshav qab zib hom 2 xav tau kev txhaj tshuaj ntawm cov tshuaj insulin ntev, ces ua ntej ntawm tag nrho cov Lantus, Levemir lossis Protafan yuav tsum tau txhaj tshuaj thaum hmo ntuj.Puas yog hais tias xav kom txhaj tshuaj insulin ntev zog thaum sawv ntxov? Nws yog nyob ntawm qhov ntsuas ntawm 'meter'. Tshawb nrhiav kom koj cov piam thaj qab zib li cas ib hnub.

Ua ntej, peb suav qhov pib pib ntawm kev insulin txuas ntxiv, thiab tom qab ntawd hnub tom ntej peb hloov kho nws kom txog thaum qhov txiaj ntsig tau txais

Hauv 7 hnub, peb ntsuas ntshav qab zib nrog ib qho glucometer thaum hmo ntuj, thiab tom qab ntawd tag kis sawv ntxov ntawm lub plab khoob.
Cov txiaj ntsig tau raug sau cia hauv lub rooj.
Peb suav rau txhua hnub: qab zib thaum sawv ntxov nyob ntawm lub plab tsis hnov qab rho tawm suab thaj nag hmo.
Peb muab pov tseg hnub uas cov kws kho ntshav qab zib tau noj hmo ua ntej 4-5 teev ua ntej yuav mus pw.
Peb pom qhov tsawg kawg nkaus tus nqi ntawm qhov nce no rau lub sijhawm soj.
Phau ntawv qhia yuav pom tias 1 UNIT ntawm insulin txo cov ntshav qab zib li cas. Qhov no hu ua qhov zoo tshaj yuav tso cov tshuaj insulin.
Faib cov khoom qab zib kom tsawg kawg nkaus hauv ib hmo los ntawm kwv yees qhov sib npaug ntawm kev nkag siab zoo rau insulin. Qhov no muab qhov pib rau peb.
Nyas rau yav tsaus ntuj qhov kev suav tshuaj ntawm cov sij hawm txuas ntxiv. Peb teeb tsa lub tswb kom tsa thaum ib tag hmo thiab tshawb xyuas qab zib.
Yog tias muaj piam thaj thaum tsaus ntuj qis dua 3.5-3.8 mmol / L, qhov koob tshuaj yav tsaus ntuj yuav tsum tau qis. Cov qauv pab - hloov chaw ntawm nws mus rau kev txhaj tshuaj ntxiv ntawm 1-3 teev sawv ntxov.
Txog ob peb hnub tom qab no, peb nce lossis txo qhov hno, sim ua ntau lub sijhawm txhaj tshuaj, kom txog rau thaum sawv ntxov cov ntshav qab zib nyob hauv qhov ib txwm li ntawm 4.6 ± 0.6 mmol / L, txhua lub sijhawm tsis muaj hmo ntuj.

Cov ntaub ntawv piv txwv rau xam qhov pib siv ntawm Lantus, Levemir lossis Protafan thaum tsaus ntuj

Peb pom tias cov ntaub ntawv rau hnub Thursday yuav tsum tau muab pov tseg, vim hais tias tus neeg mob tau noj hmo tas li. Hnub so, hnub qab zib nce qib tsawg kawg yog tsaus ntuj hnub Friday. Nws ntau txog 4.0 mmol / L. Peb coj txoj kev loj hlob yam tsawg kawg nkaus, thiab tsis yog qhov siab tshaj plaws lossis txawm qhov nruab nrab. Lub hom phiaj yog kom tau txais cov tshuaj insulin pib qis dua es tsis txhob siab. Qhov no ntxiv kev pov hwm tus neeg mob tawm tsam nocturnal hypoglycemia. Cov kauj ruam tom ntej yog kom pom cov kwv yees qhov sib npaug ntawm kev nkag siab zoo rau insulin los ntawm cov nqi ntawm lub rooj.

Piv txwv nyob rau hauv tus neeg mob uas muaj ntshav qab zib hom 1, tus txiav ua kom tiav tsis tsim nws cov tshuaj insulin. Hauv qhov no, 1 koog ntawm cov insulin txuas ntxiv yuav ua rau cov ntshav qab zib tsawg dua li 2.2 mmol / L hauv ib tus neeg hnyav 64 kg. Qhov ntau koj hnyav, qhov ua kom qaug zog ntawm cov tshuaj insulin. Piv txwv li, rau tus neeg hnyav 80 kg, 2.2 mmol / L * 64 kg / 80 kg = 1.76 mmol / L yuav tau txais. Peb daws cov teeb meem los ntawm kev suav qhov feem ntawm qhov kawm hauv tsev kawm theem pib laij zauv.

Rau cov neeg mob uas muaj ntshav qab zib hom 1 loj tshaj plaws, peb coj tus nqi no ncaj qha. Tab sis rau cov neeg mob uas muaj ntshav qab zib hom 2 lossis hom ntshav qab zib hom 1 hauv daim ntawv me, nws yuav dhau siab. Piv txwv koj tus txiav ua qab zib tseem ua kua dej insulin. Txhawm rau tshem tawm qhov kev pheej hmoo ntawm hypoglycemia, peb yuav xub xav txog "nrog cov npoo" uas 1 ntu ntawm cov insulin txo qis cov ntshav qab zib kom ntau li 4.4 mmol / l thiab hnyav 64 kg. Koj yuav tsum txiav txim siab tus nqi no rau koj qhov hnyav. Ua ib qho kev faib ua feem, xws li ua piv txwv saum toj no. Rau tus menyuam uas hnyav 48 kg, 4.4 mmol / L * 64 kg / 48 kg = 5.9 mmol / L yuav tau txais. Rau cov neeg mob zoo uas muaj ntshav qab zib hom 2 nrog lub cev hnyav 80 kg, yuav muaj 4.4 mmol / l * 64 kg / 80 kg = 3.52 mmol / l.

Peb tau pom tias rau peb tus neeg mob, qhov tsawg kawg ntawm kev nce siab hauv cov ntshav qab zib ib hmo yog 4.0 mmol / L. Nws lub cev hnyav yog 80 kg. Rau nws, raws li kev ntsuas "ceev faj" ntawm 1 U ntawm cov tshuaj insulin ntev, nws yuav txo cov ntshav qab zib kom tsawg li 3.52 mmol / L. Hauv qhov no, rau nws, kev pib muab cov tshuaj insulin thaum tsaus ntuj yuav yog 4.0 / 3.52 = 1.13 units. Sau kom ze rau 1/4 PIECES ze thiab tau 1.25 PIECES. Txhawm rau txhawm rau txhawm rau qhov kev txhaj tshuaj qis no, koj yuav tsum kawm paub txhawm rau insulin. Lantus yuav tsum tsis txhob qhaj. Yog li ntawd, nws yuav tsum tau txaij 1 koog lossis tam sim ntawd 1.5 yam. Yog tias koj siv Levemir hloov Lantus, tom qab ntawd ntuag nws kom raug txhaj 1.25 PIECES.

Yog li, lawv tau txhaj cov koob tshuaj thaum pib txuas ntxiv thaum hmo ntuj. Hnub tom ntej, peb kho nws - nce lossis txo kom txog thaum muaj suab thaj thaum sawv ntxov nyob rau ntawm lub plab khoob yog qhov ruaj khov ntawm 4.6 ± 0.6 mmol / l. Yuav kom ua tiav qhov no, koj yuav tsum cais cov koob tshuaj Lantus, Levemir lossis Protafan rau yav hmo ntuj thiab prick ib feem tom qab ntawm ib tag hmo. Nyeem cov ntsiab lus saum toj no hauv kem “Yuav ua li cas ua kom qab zib sai thaum sawv ntxov”.

Txhua txhua hom 1 lossis hom 2 cov neeg mob ntshav qab zib uas nyob rau hauv kev noj haus cov zaub mov uas muaj carbohydrate tsawg yuav tsum kawm paub txhawm rau txhawm rau tshuaj insulin kom raug txhaj tshuaj qis. Thiab yog tias koj tseem tsis tau hloov mus rau kev noj zaub mov kom tsis rog nrog cov zaub mov qab zib, yog li koj ua dabtsi ntawm no?

Yog li, peb xam tawm yuav laij kwv yees cov pib kwv yees ncua ntawm insulin thaum hmo ntuj. Yog tias koj tau kawm kev laij zauv hauv tsev kawm, tom qab ntawd koj tuaj yeem kho nws. Tab sis qhov ntawd tsuas yog qhov pib xwb. Vim tias qhov pib noj tshuaj zoo li yuav yog qhov tsawg dua lossis nce siab dua. Yuav kom kho cov koob tshuaj ntawm cov insulin ntev ntev thaum hmo ntuj, koj sau koj cov piam thaj hauv ntshav thaum mus pw rau ob peb hnub, thiab tom qab ntawv thaum sawv ntxov ntawm lub plab khoob. Yog tias qhov siab tshaj plaws nce hauv qab zib hauv ib hmo tsis siab dua li 0.6 mmol / l - tom qab ntawd cov koob tshuaj yog qhov tseeb. Hauv qhov no, koj yuav tsum coj mus rau hauv tus account tsuas yog cov hnub uas koj tau noj hmo tsis pub dhau 5 teev ua ntej mus pw. Noj thaum ntxov yog ib qho tseem ceeb rau cov neeg mob ntshav qab zib uas tau raug kho mob los ntawm insulin.

Yog tias qhov nce siab tshaj hauv cov piam thaj hauv ib hmo dhau ntawm 0.6 mmol / L - nws txhais tau hais tias qhov koob tshuaj thaum yav tsaus ntuj txuas ntxiv insulin yuav tsum tau sim nce. Yuav ua li cas yuav ua rau nws? Nws yog ib qho tsim nyog yuav tau nce nws los ntawm 0.25 PIECES txhua 3 hnub, thiab tom qab ntawd txhua txhua hnub los saib xyuas seb qhov no yuav cuam tshuam li cas hmo ntuj nce ntxiv nyob rau hauv cov ntshav qab zib. Txuas ntxiv maj mam nce cov koob tshuaj kom txog rau thaum cov piam thaj thaum sawv ntxov tsis tshaj 0.6 mmol / L siab dua koj cov qab zib yav tsaus ntuj. Rov nyeem dua yuav ua li cas tswj thaum sawv ntxov thaum kaj ntug.

Li cas los xaiv qhov zoo tshaj koob ntawm cov tshuaj insulin thaum hmo ntuj:

Koj yuav tsum tau kawm paub noj mov kom ntxov, 4-5 teev ua ntej yuav mus pw.
Yog tias koj tau noj hmo lig, tom qab ntawd ib hnub twg yuav tsis haum rau kev kho qhov tshuaj ntxiv ntawm cov tshuaj insulin thaum hmo ntuj.
Ib zaug ib lim tiam nyob rau hnub sib txawv, xyuas koj cov qab zib ib nrab hnub. Nws yuav tsum muaj tsawg kawg yog 3.5-3.8 mmol / L.
Ua kom ntau zog rau yav tsaus ntuj koob tshuaj txuas ntxiv yog tias ntev li 2-3 hnub hauv kab qab zib thaum sawv ntxov ntawm lub plab tsis muaj dab tsi ntau tshaj 0.6 mmol / L siab dua nws tau ua nag hmo ua ntej yuav mus pw.
Dhau ntawm taw qhia - xav txog tsuas yog cov hnub thaum koj tau noj hmo thaum ntxov!
Rau cov neeg mob uas muaj ntshav qab zib hom 1 thiab ntshav qab zib hom 2 uas ua raws li cov zaub mov uas muaj protein ntau. Qhov kev txhaj tshuaj ntawm cov insulin ntev dhau ib hmo yog pom zoo kom nce los ntawm tsis ntau tshaj 0.25 units txhua 3 hnub. Lub hom phiaj yog txhaus koj tus kheej kom ntau li ntau tau los ntawm nocturnal hypoglycemia.
Tseem Ceeb! Yog tias koj tau tshaj tawm cov tshuaj insulin yav tsaus ntuj - 2-3 hnub ntxiv, nco ntsoov xyuas koj cov piam thaj hauv ib tag hmo.
Yuav ua li cas yog tias cov piam thaj thaum hmo ntuj txia ntshis ua qis dua li qub los yog npau suav phem thab koj? Yog li, koj yuav tsum txo qis cov koob tshuaj insulin, uas txhaj ua ntej yuav mus pw.
Yog tias koj xav tau qis dua li kev noj tshuaj yav tsaus ntuj ntawm cov tshuaj insulin, nws raug nquahu kom hloov qee qhov ntawm nws mus rau kev txhaj tshuaj ntxiv thaum 1-3 teev sawv ntxov.

Nightly hypoglycemia nrog tus npau suav phem yog qhov tsis zoo txaus ntshai thiab txawm tias txaus ntshai yog tias koj nyob ib leeg. Cia peb paub yuav tiv thaiv nws li cas thaum koj nyuam qhuav pib kho koj cov ntshav qab zib nrog kev txhaj tshuaj ntxiv thaum tsaus ntuj. Teeb lub tswb kom nws tsa koj li 6 teev tom qab txhaj tshuaj. Thaum koj sawv, ntsuas koj cov ntshav qab zib nrog ib glucometer. Yog tias nws qis dua 3.5 mmol / l, noj me ntsis carbohydrates kom tsis muaj ntshav qab zib. Soj ntsuam koj cov suab thaj hmo thaum ntxov ntawm kev kho mob ntshav qab zib insulin, zoo li txhua zaus koj sim nce cov tshuaj insulin ntau hmo. Txawm hais tias ib kis zoo li no txhais tau tias yuav tsum tau txhaj koob tshuaj.

Yuav luag txhua tus neeg mob ntshav qab zib qis yuav tsum tau txhaj tshuaj ntxiv ib hnub twg tsawg dua 8 ib pawg. Ib qho kev zam rau txoj cai no yog cov neeg mob uas muaj hom 1 lossis 2 mob ntshav qab zib, rog dhau, mob ntshav qab zib, thiab tib neeg tam sim no muaj kab mob kis. Yog tias koj txhaj cov tshuaj insulin txuas ntxiv thaum hmo ntuj ntawm 7 koob lossis ntau dua, ces nws cov khoom hloov pauv, piv nrog cov koob tshuaj me. Nws kav ntev npaum li cas. Hypoglycemia tej zaum yuav tshwm sim ua ntej noj hmo tom qab. Txhawm rau zam cov teeb meem no, nyeem "Yuav ua li cas txhaj tshuaj insulin ntau" thiab ua raws li cov lus pom zoo.

Yog tias koj xav tau qhov koob tshuaj Lantus, Levemir lossis Protafan thaum yav tsaus ntuj, qhov ntawd yog, nws ntau tshaj 8 units, tom qab ntawd peb xav kom faib nws tom qab thaum ib tag hmo. Nyob rau yav tsaus ntuj, cov neeg mob ntshav qab zib npaj txhua yam tsim nyog yuav tsum tau, teeb tsa lub moos ceeb toom rau thaum ib tag hmo, ua rau nws hu mus rau hauv lub xeev uas tsis nco qab lawm, thiab tam sim ntawd tsaug zog dua. Vim tias qhov no, cov txiaj ntsig kho mob ntshav qab zib tau zoo dua. Nws tsim nyog kom tsis yooj yim los tiv thaiv kev mob ntshav qab zib thiab kom cov ntshav qab zib ib txwm nyob tag kis. Ntxiv mus, qhov tsis yooj yim yuav muaj tsawg heev thaum koj kawm kho cov txheej txheem ntawm cov tshuaj insulin tsis muaj tshuaj.

Yog li, peb tau xam seb yuav ua li cas txhav txhawm rau Latnus, Levemir lossis Protafan rau hmo ntuj. Ua ntej, peb txiav txim siab seb puas yuav ua qhov no txhua. Yog tias nws hloov tawm tias koj xav tau, ces peb suav thiab muaj feem rau cov tshuaj pib. Thiab tom qab ntawd peb kho nws kom txog thaum qab zib thaum sawv ntxov ntawm lub plab khoob ib txwm yog 4.6 ± 0.6 mmol / l. Thaum ib tag hmo, nws yuav tsum tsis poob qis dua 3.5-3.8 mmol / L. Qhov tseem ceeb uas koj tau kawm ntawm peb lub vev xaib yog kom txhaj tshuaj insulin ntxiv nyob hauv ib tag hmo kom tswj thaum sawv ntxov. Ib feem ntawm qhov koob tshuaj yav tsaus ntuj yog pauv mus rau nws.

Tam sim no cia peb txiav txim siab thaum sawv ntxov ntawm cov insulin txuas ntxiv. Tab sis ntawm no tuaj qhov nyuaj. Txhawm rau daws teeb meem nrog kev txhaj tshuaj ntawm cov tshuaj insulin txuas ntxiv thaum sawv ntxov, koj yuav tsum tau tshaib plab thaum nruab hnub los ntawm hmo ua hmo. Peb txhaj Lantus Levemir lossis Protafan los ua kom cov piam thaj sai sai. Thaum hmo ntuj koj tsaug zog thiab tshaib plab ib txwm muaj. Thiab yav tav su los saib xyuas cov piam thaj hauv ib plab khoob, koj yuav tsum ceev faj kom tsis txhob noj mov. Hmoov tsis zoo, qhov no tsuas yog txoj hauv kev tseeb los laij cov sawv ntxov ntawm cov tshuaj insulin thaum sawv ntxov. Cov txheej txheem hauv qab no yog piav qhia txhua yam.

Piv txwv koj muaj dhia hauv qab zib thaum nruab hnub lossis nws pheej nce siab ntxiv. Cov lus nug ntawm qhov tseem ceeb: koj cov piam thaj puas nce los ntawm kev noj mov lossis ntawm lub plab khoob? Rov qab hais tias cov tshuaj insulin txuas ntxiv yog xav kom tswj cov suab thaj kom sai, thiab ceev ceev - kom tsis txhob muaj cov piam thaj hauv ntshav ntxiv tom qab noj mov. Peb kuj tseem siv cov tshuaj tua kab hluav taws (ultrashort insulin) kom nrawm qab zib kom ib txwm yog nws tseem dhia.

Ua kom cov ntshav qab zib tom qab noj cov insulin luv luv, lossis txhaj cov insulin txuas ntxiv thaum sawv ntxov kom cov piam thaj ib txwm ntawm ib plab plab txhua hnub yog qhov txawv. Yog li, nws yog qhov tseem ceeb heev kom paub txog seb koj cov piam thaj coj li cas thaum nruab hnub, thiab tsuas yog tom qab ntawd tau sau tshuaj kho insulin rau lub hnub. Cov kws tshaj lij cov kws kho mob thiab cov ntshav qab zib tau sim siv cov tshuaj insulin luv nyob rau nruab hnub uas xav tau ntev ntev, thiab rov ua dua. Cov txiaj ntsig yog deplorable.

Nws yog qhov tsim nyog los ntawm kev sim ua kom paub seb koj cov piam thaj hauv ntshav yuav ua licas thaum nruab hnub. Nws puas sawv los ntawm kev noj mov lossis ntawm lub plab khoob ib yam nkaus? Hmoov tsis zoo, koj yuav tsum tshaib plab kom tau txais cov ntaub ntawv no. Tab sis ib qho kev sim yog qhov tsim nyog tiag. Yog tias koj tsis tas yuav hno cov tshuaj insulin ntev ntev thaum hmo ntuj los them rau yav sawv ntxov thaum kaj ntug, ces nws tsis zoo li tias koj cov piam thaj hauv ntshav yuav nce thaum nruab hnub ntawm lub plab khoob. Tab sis tseem koj yuav tsum txheeb xyuas thiab paub tseeb. Ntxiv mus, koj yuav tsum ua qhov kev sim yog tias koj tau txhaj tshuaj ntxiv thaum tsaus ntuj.

Yuav ua li cas xaiv cov koob tshuaj ntawm Lantus, Levemir lossis Protafan thaum sawv ntxov:

Hnub ntawm kev sim, tsis txhob noj tshais lossis su, tab sis npaj noj hmo 13 teev tom qab koj sawv. Nov yog lub caij uas koj tseem cia sijhawm tsaus ntuj xwb.
Yog tias koj noj Siofor lossis Glucofage Ntev, tom qab ntawd noj koj li ib txwm noj thaum sawv ntxov.
Haus dej kom txaus nyob thoob plaws hnub; koj tuaj yeem siv tshuaj yej ntsuab yam tsis muaj qab zib. Tsis txhob mob siab rau qhuav. Kas fes, cocoa, dub thiab ntsuab dej xas - nws zoo dua tsis haus.
Yog tias koj noj tshuaj kho ntshav qab zib uas tuaj yeem ua rau ntshav qab zib tau qis, ces hnub no tsis txhob noj lawv thiab feem ntau tso lawv tseg. Nyeem seb hom tshuaj ntshav qab zib twg tsis zoo thiab yam twg zoo.
Ntsuas koj cov piam thaj hauv ntshav nrog lub ntsuas ntshav qab zib sai sai thaum koj sawv, tom qab ntawv rov qab 1 teev, tom qab 5 teev, tom qab 9 teev, tom qab 12 teev thiab 13 teev ua ntej noj hmo. Nyob rau hauv tag nrho, koj yuav siv 5 ntsuas thaum nruab hnub.
Yog tias thaum 13 teev ntawm kev yoo mov txhua hnub nce ntxiv ntawm ntau dua 0.6 mmol / l thiab tsis poob, tom qab ntawd koj xav tau txhaj tshuaj insulin thaum sawv ntxov nyob rau ntawm lub plab khoob. Peb suav cov koob tshuaj ntawm Lantus, Levemir lossis Protafan rau cov kev txhaj tshuaj no zoo ib yam li cov tshuaj txuas ntxiv thaum hmo ntuj.

Hmoov tsis zoo, txhawm rau kho lub sijhawm thaum sawv ntxov ntawm insulin ntev ntev, koj yuav tsum yoo mov kom zoo ib yam nkaus rau ib hnub tsis tiav thiab saib seb ntshav qab zib cov ntshav coj li cas rau hnub no. Ciaj sia nyob kev tshaib plab hnub ob zaug hauv ib lub lis piam tsis kaj siab heev. Yog li, tos kom txog rau lub asthiv tom ntej ua qhov kev sim tib yam kom kho koj lub koob tshuaj thaum sawv ntxov ntev. Peb taw qhia tias txhua qhov txheej txheem muaj teeb meem no tsuas yog tsim nyog rau cov neeg mob uas ua raws li cov zaub mov tsis muaj roj ntau ntau thiab sim ua kom muaj suab thaj zoo li qub 4.6 ± 0.6 mmol / L. Yog tias qhov sib txawv ntawm ± 2-4 mmol / l tsis thab koj, ces koj tsis tuaj yeem thab.

Nrog tus mob ntshav qab zib hom 2, pom tau tias koj xav tau txhaj tshuaj sai sai ua ntej noj mov, tab sis koj tsis tas yuav txhaj cov insulin txuas ntxiv thaum sawv ntxov. Txawm li cas los xij, qhov no tsis tuaj yeem kwv yees tsis tau kev sim, yog li tsis txhob tub nkeeg kom coj nws tawm.

Piv txwv tias koj pib kho cov ntshav qab zib hom 2 nrog kev ncua tshuaj insulin thaum hmo ntuj, thiab tej zaum tseem tuaj thaum sawv ntxov. Tom qab ib ntus, koj yuav pom qhov tseeb ntawm cov tshuaj insulin txhawm rau kom cov ntshav qab zib sai li 24 teev nyob rau ib hnub. Raws li qhov tshwm sim ntawm qhov no, tus txiav ua ke tuaj yeem cuam tshuam li ntawd txawm tias tsis muaj qhov xav tau ntawm cov tshuaj insulin nws yuav nquag ua kom muaj suab thaj ntau ntxiv tom qab noj mov. Qhov no feem ntau tshwm sim nrog cov mob sib khuav ntawm hom 2 mob ntshav qab zib. Tab sis yog tias tom qab noj koj cov ntshav qab zib kom ntau dua 0.6 mmol / L siab dua li ib txwm muaj rau cov neeg noj qab haus huv, nws txhais tau tias koj tseem xav tau txhaj tshuaj insulin luv ua ntej noj mov. Rau cov ntsiab lus ntxaws ntxiv, saib "Kev xam ntawm cov koob tshuaj sai ntawm cov insulin ua ntej noj mov."

Kev nthuav tshuaj insulin Lantus thiab Levemir: cov lus teb rau cov lus nug

Glycated hemoglobin txo qis mus rau 6.5% - zoo, tab sis tseem muaj haujlwm yuav ua :). Lantus tuaj yeem hlais tau ob hnub ib hnub. Ntxiv mus, peb xav kom txhua tus ua qhov no los txhim kho kev tswj ntshav qab zib. Muaj qee qhov laj thawj los xaiv Levemir hloov ntawm Lantus, tab sis lawv tsis muaj txiaj ntsig. Yog tias Lantus raug muab pub dawb, tab sis Levemir - tsis yog, tom qab ntawd hno cov tshuaj insulin ob zaug ib hnub uas lub xeev muab rau koj.

Raws li rau qhov tsis sib xws ntawm Lantus thiab NovoRapid thiab lwm yam kev hloov pauv ntawm cov kua dej los ntawm cov tuam ntxhab sib txawv. Cov no yog cov lus xaiv ruam, tsis lees paub los ntawm ib yam dab tsi. Txaus siab rau lub neej thaum koj tau txais cov tshuaj insulin zoo rau dawb. Yog tias koj yuav tsum hloov mus rau hauv tsev, tom qab ntawd koj tseem yuav nco txog lub sijhawm no nrog nostalgia. Hais txog "nws tau ua kev nyuaj rau kuv los pab them cov ntshav qab zib." Hloov mus rau kev noj haus cov zaub mov kom tsis txhob rog thiab ua raws li tag nrho lwm cov dej num teev hauv peb hom phiaj xwm ntshav qab zib hom 1. Kuv pom zoo kom txhaj Lantus tsawg kawg ob zaug hauv ib hnub, yav sawv ntxov thiab yav tsaus ntuj, thiab tsis yog ib zaug, raws li txhua tus nyiam ua.

Kuv yuav nyob hauv koj qhov chaw, Rov qab, mob siab rau Lantus, thiab ob zaug ib hnub, thiab tsis yog thaum tsaus ntuj. Hauv qhov no, koj tuaj yeem sim ua kom tsis muaj kev siv tshuaj los ntawm Apidra. Hloov mus rau qhov kev noj haus cov zaub mov kom tsis txhob rog thiab ua raws txhua yam haujlwm tau hais tseg hauv hom 2 kho mob ntshav qab zib. Ua kev saib xyuas ntshav qab zib tag nrho 1-2 zaug hauv ib lub lis piam.Yog tias koj ua tib zoo ua raws li kev noj zaub mov noj, noj tshuaj rau ntshav qab zib hom 2, thiab tseem ntau tshaj yog ua kev tawm dag zog lub cev nrog kev lom zem, tom qab ntawd muaj 95% qhov koj yuav ua tau yam tsis muaj kev txhaj tshuaj insulin txhua. Yog tias tsis muaj suab thaj koj cov piam thaj tseem yuav nyob siab dua li ib txwm, tom qab ntawd txhaj Lantus ua ntej. Kev hno ntshav ntawm cov insulin sai ua ntej noj mov rau hom ntshav qab zib hom 2 tsuas yog xav tau nyob rau hauv cov mob hnyav tshaj plaws, yog tias tus neeg mob dhau mus dhau los ua raws li cov zaub mov uas tsis muaj carbohydrate thiab feem ntau ua raws li kev tswj hwm.

Nyeem kab lus “Cov Kev Txhaj Tshuaj insulin”. Xyaum ua me ntsis - thiab kawm paub yuav ua li cas cov kev txhaj tshuaj no tsis mob kiag li. Qhov no yuav coj tau txiaj ntsig zoo rau koj tsev neeg tag nrho.

Yog, nws yog. Ntxiv mus, koj yuav tsum txawm yuav Lantus lossis Levemir rau koj cov nyiaj, tsis txhob siv cov "nruab nrab" protafan dawb. Vim li cas - tham nyob rau hauv kom meej saum toj no.

Neuropathy, mob ntshav qab zib ko taw thiab lwm cov teeb meem yog nyob ntawm seb koj tswj hwm li cas kom koj cov ntshav qab zib nyob ze li qub. Cov tshuaj insulin koj siv dab tsi tsis tseem ceeb yog tias nws pab txhawm rau them ntshav qab zib kom zoo. Yog tias koj hloov los ntawm protafan mus rau Levemir lossis Lantus ua lub zog insulin ntxiv, tom qab ntawd tswj kev mob ntshav qab zib tau yooj yim dua. Tus mob ntshav qab zib tau tshem ntawm kev mob thiab lwm cov tsos mob ntawm mob neuropathy - qhov no yog vim lawv tau txhim kho cov ntshav qab zib kom tsawg. Thiab cov hom insulin tshwj xeeb tsis muaj dab tsi ua rau nws. Yog tias koj muaj kev txhawj xeeb txog neuropathy, tom qab ntawd nyeem kab lus ntawm alpha lipoic acid.

Los ntawm kev sim nrog kev txhaj tshuaj ntawm cov tshuaj insulin txuas ntxiv, koj tuaj yeem txhim kho koj cov piam thaj thaum sawv ntxov ntawm ib qho khoob khoob. Yog tias koj noj zaub mov "sib npaug", tshaj nrog cov carbohydrates, ces koj yuav tsum siv cov tshuaj Levemir ntau ntau. Hauv qhov no, sim ua ntej txhaj tshuaj thaum yav tsaus ntuj ntawm 22.00-00.00. Tom qab ntawd lub siab tshaj plaws ntawm nws qhov kev nqis tes ua yuav nyob rau ntawm 5.00-8.00 thaum sawv ntxov, thaum qhov tshwm sim ntawm thaum sawv ntxov ntxov tau pom los kom ntau li ntau tau. Yog tias koj hloov mus rau kev noj haus cov zaub mov uas tsis muaj carbohydrate thiab koj cov koob tshuaj ntawm Levemir tsawg, nws pom zoo kom hloov mus rau 3 lossis txawm tias 4 hno ib hnub los ntawm 2-lub sijhawm tswj hwm. Thaum xub thawj, qhov no yog qhov teeb meem, tab sis koj sai sai siv rau nws, thiab sawv ntxov qab zib pib ua rau koj zoo siab heev.

Koj cov kws kho mob paub meej tias tsis muaj dab tsi ua. Yog tias nyob rau 4 lub xyoo koj tsis tau tsim kev fab tshuaj rau insulin, ces nws tsis zoo li nws yuav tshwm sim sai. Kuv kos duab rau cov hauv qab no. Kev noj zaub mov zoo rau cov ntshav qab zib kom tsis tsuas txhim kho cov ntshav qab zib, tab sis kuj tseem txo qhov muaj feem ua xua. Vim tias yuav luag txhua cov khoom lag luam uas tuaj yeem ua rau ua xua, peb cais tawm ntawm cov khoom noj, tsuas yog rau cov qe qaib.

Tsis yog, tsis muaj tseeb. Muaj lus xaiv tias Lantus ua rau mob qog noj ntshav, tab sis lawv tseem tsis tau lees paub. Xav tias xav hloov ntawm protafan mus rau Levemir lossis Lantus - txuas ntxiv cov tshuaj insulin. Muaj qee qhov laj thawj vim li cas nws yog qhov zoo dua los xaiv Levemir dua li Lantus. Tab sis yog tias Lantus tau muab tshuaj pub dawb, tab sis Levemir - tsis yog, tom qab ntawd maj mam txhaj cov tshuaj insulin dawb. Lus khaws xav Peb pom zoo kom txhaj Lantus ob rau peb zaug ib hnub, thiab tsis yog ib zaug.

Koj tsis qhia koj lub hnub nyoog, qhov siab, qhov hnyav, hom mob ntshav qab zib thiab sijhawm nyob hauv qhov tsis muaj qab hau. Nws tsis muaj qhov pom tseeb rau koj lo lus nug. Koj tuaj yeem faib 15 units ib nrab. Los yog txo tag nrho cov koob tshuaj los ntawm 1-2 units thiab twb tau faib nws ib nrab. Lossis koj tuaj yeem pleev ntau thaum yav tsaus ntuj dua li thaum sawv ntxov los txhawm rau thaum sawv ntxov. Tag nrho cov no yog tus neeg. Ua kom tswj tus kheej los ntawm cov ntshav qab zib thiab tau ua pov thawj los ntawm nws cov txiaj ntsig. Nyob rau hauv txhua rooj plaub, hloov ntawm ib qho Lantus txhaj ib hnub rau ob yog qhov raug.

Nws tsis muaj lus teb meej rau koj cov lus nug. Ua kom tswj tus kheej los ntawm cov ntshav qab zib thiab tau ua pov thawj los ntawm nws cov txiaj ntsig. Nov yog tib txoj kev los xaiv qhov kev ncua ntev thiab ceev tshaj tawm cov tshuaj insulin. Kuv xav kom koj xam phaj nrog cov niam txiv ntawm cov menyuam muaj hnub nyoog 6 xyoo uas muaj mob ntshav qab zib hom 1. Lawv tswj kom dhia tawm cov tshuaj insulin kom zoo tom qab lawv hloov mus rau qhov kev noj haus kom yog.

Siv tshuaj insulin ntau, uas Levemir nyob tsis yog, tsis yog xav kom txo qis ntshav qab zib kom sai. Lub hom phiaj ntawm nws txoj kev siv yog sib txawv. Qab zib hauv koj qhov xwm txheej nce siab nyob hauv qab ntawm cov zaub mov uas nyuam qhuav noj. Qhov no txhais tau hais tias qhov koob tshuaj sai ntawm cov kua dej ua ntej noj mov tsis raug xaiv tsis raug. Thiab, feem ntau yuav yog, lub ntsiab yog noj zaub mov tsis zoo. Nyeem peb Qhov Hom Ntshav Qab Zib Hom 1 lossis Hom Ntshav Qab Zib Hom 2. Tom qab ntawv, ua tib zoo kawm tag nrho cov lus hauv Insulin.

Hauv tsab xov xwm, koj tau kawm txhua yam zoo li Lantus thiab Levemir, cov insulin ntev ntev, thiab nruab nrab NPH-insulin protafan yog dab tsi. Peb tau xam tawm yog vim li cas nws yog qhov tseeb rau siv cov kev txhaj tshuaj ntawm cov tshuaj insulin ntxiv thaum hmo ntuj thiab thaum sawv ntxov, thiab rau lub hom phiaj twg nws tsis yog lawm. Qhov tseem ceeb uas yuav tsum tau kawm: kev ua lub cev ntev ntev los tiv thaiv cov kab mob ntshav qab zib sai. Nws tsis yog rau tua cov dhia hauv qab zib tom qab noj mov.

Tsis txhob sim siv cov tshuaj insulin txuas ntxiv qhov twg luv los sis luv luv qhov xav tau. Nyeem kab lus “Ultrashort Insulin Humalog, NovoRapid thiab Apidra. Tib Neeg Muaj Insulin luv luv thiab ”Kev txhaj tshuaj ntawm cov insulin ceev ua ntej noj mov. Yuav ua li cas kom qis qab zib rau li qub yog tias nws dhia. " Kev kho koj cov ntshav qab zib kom txaus nrog insulin yog tias koj xav kom zam nws cov teeb meem.

Peb tau saib yuav ua li cas los laij cov tshuaj uas tsim nyog ntawm cov tshuaj insulin ntxiv thaum tsaus ntuj thiab thaum sawv ntxov. Peb qhov kev pom zoo yog qhov txawv ntawm qhov tau sau hauv phau ntawv nrov thiab dab tsi yog qhia hauv "tsev kawm mob ntshav qab zib". Nrog kev pab los ntawm kev ua tib zoo saib xyuas tus menyuam cov ntshav qab zib, nco ntsoov tias peb cov hauv kev muaj txiaj ntsig zoo dua, txawm hais tias lub sijhawm ua haujlwm zoo. Los xam thiab kho qhov ntau npaum li cas ntawm kev txuas ntxiv tshuaj thaum sawv ntxov, koj yuav tsum hla kev noj tshais thiab noj su. Qhov no tsis txaus siab heev, tab sis, alas, ib txoj kev zoo dua tsis muaj nyob. Xam thiab kho qhov ntau npaum li cas ntawm kev txuas ntxiv cov insulin thaum hmo ntuj yog yooj yim dua, vim tias thaum hmo ntuj, thaum koj pw, koj tsis noj nyob rau hauv txhua kis.

Kev siv tshuaj insulin Lantus, Levemir thiab protafan ntxiv yog xav kom muaj suab thaj ib txwm nyob ib plab khoob rau ib hnub.
Ultrashort thiab insulin luv luv - tso cov suab thaj uas tau tshwm sim tom qab noj mov.
Tsis txhob sim siv cov tshuaj insulin ntau dua li qhov hloov cov tshuaj insulin sai ua ntej noj mov!
Cov tshuaj insulin twg zoo dua - Lantus lossis Levemir? Teb: Levemir muaj qhov zoo me me. Tab sis yog tias koj tau txais Lantus dawb, tom qab ntawd calmly prick nws.
Ntawm hom 2 mob ntshav qab zib, thawj zaug txhaj txuas ntxiv insulin thaum hmo ntuj thiab / lossis thaum sawv ntxov, thiab tom qab ntawd mam li yaug insulin ua ntej noj mov, yog tias tsim nyog.
Nws yog qhov pom zoo kom hloov los ntawm protafan mus rau Lantus lossis Levemir, txawm tias koj yuav tsum yuav cov tshuaj insulin ntxiv rau koj cov nyiaj.
Tom qab hloov mus rau kev noj haus cov zaub mov kom tsawg rau cov ntshav qab zib hom 1 lossis 2, cov koob tshuaj ntawm txhua hom tshuaj insulin raug txo los ntawm 2-7 zaug.
Kab lus qhia cov lus qhia ib qib zuj zus hais txog yuav ua li cas los xam qhov ntau npaum li cas ntawm cov tshuaj insulin thaum hmo ntuj thiab thaum sawv ntxov. Tshawb nrhiav lawv!
Nws raug nquahu kom txhaj ntxiv Lantus, Levemir lossis Protafan ntawm 1-3 a.m. txhawm rau tswj tau qhov xwm txheej zoo thaum sawv ntxov.
Cov neeg mob ntshav qab zib, uas tau noj hmo 4-5 teev ua ntej yuav mus pw thiab ntxiv cov koob tshuaj insulin ntxiv thaum 1-3 teev sawv ntxov, muaj cov piam thaj ib txwm nyob rau yav sawv ntxov ntawm lub plab khoob.

Kuv vam tias tsab xov xwm no tau pab tau koj. Yog tias ua tau, nws raug nquahu kom hloov nruab nrab NPH-insulin (protafan) nrog Lantus lossis Levemir txhawm rau txhim kho cov txiaj ntsig ntawm kev kho mob ntshav qab zib. Hauv cov lus pom, koj tuaj yeem nug cov lus nug txog kev kho ntshav qab zib nrog cov tshuaj insulin txuas ntxiv. Tus xaib ntawm kev xaib sai teb.

Mechanism ntawm kev ua haujlwm

Tus kws tshuaj Levemir yog ib qho tshuaj tiv thaiv ntawm tib neeg cov tshuaj insulin. Nws muaj cov nyhuv kho ntev ntev thiab siv dav los kho ntshav qab zib. Cov nquag ua haujlwm ntawm Levemir tau faib qeeb qeeb dua cov ntaub so ntswg, thiab vim qhov no, cov nyhuv ntawm cov tshuaj nce ntxiv. Kev siv cov suab thaj hauv cov ntshav tau los ntawm kev nqus ntawm cov piam thaj los ntawm cov ntaub so ntswg thiab txo nws lub siab tso tawm los ntawm daim siab. Lub sijhawm ntawm cov nyhuv kho tau ntawm Levemir yog 24 teev thiab, vim qhov no, cov tshuaj insulin ntev ntev tuaj yeem siv 1 lossis 2 zaug ib hnub. Hauv qhov no, cov tshuaj pib ua tom qab 4-6 teev, peaks tshwm sim tom qab 10-18 teev. Hauv cov neeg mob ntshav qab zib hom 2 uas tau txhaj tshuaj rau Levemir thiab noj cov tshuaj hypoglycemic qhov ncauj nrog nws, qhov txo qis ntawm cov zaus ntawm nocturnal hypoglycemia tau sau tseg.

Qab zib yog txo tam sim ntawd! Mob ntshav qab zib ntev mus ntev tuaj yeem ua rau tag nrho cov kab mob, xws li teeb meem tsis pom kev, tawv nqaij thiab plaub hau, mob rau sab hauv, mob caj pas thiab mob qog nqaij hlav! Cov neeg qhia kev iab kev xav mus li qub rau lawv qab zib. nyeem rau.

Cov tshuaj "Lantus" ua yeeb yam, zoo li nws cov analogue - txo qis ntshav qabzib. Txawm li cas los xij, kho kev ua haujlwm ntawm cov tshuaj no tau ua tiav vim yog cov tshuaj insulin glargine tam sim no hauv nws cov muaj pes tsawg leeg. "Lantus" kuj tseem yog cov tshuaj kho tau ntev ntev, qhov siab tshaj plaws uas tshwm sim hauv 8-10 teev. Tom qab qhia rau hauv cov rog subcutaneous, kev daws teeb meem, nyob rau hauv kev cuam tshuam ntawm acidity, cov ntaub ntawv microprecipitates, los ntawm cov tshuaj insulin yog tso tawm tsawg tsawg, tsim ib qho zoo ntawm cov tshuaj yeeb dej caw thaum lub sijhawm.

Dimka Shergin sau ntawv 03 Lub Plaub Hlis, 2017: 118

Escherichia coli (Escherichia coli, lat. Escherichia coli, hom luv luv E. coli) yog hom kab mob gram-tsis zoo li cov pas nrig, cov kab mob ntsej muag, uas yog ib feem ntawm microflora li qub ntawm tib neeg lub plab zom mov.

Muaj ntau tus naj npawb ntawm ntau yam ntawm Escherichia coli (Escherichia coli), suav nrog ntau tshaj 100 pathogenic ("enterovirulent") Cov hom, sib xyaw ua ke hauv plaub chav kawm: enteropathogenic, enterotoxigenic, enteroinvasive thiab enterohemorrhagic. Tsis muaj morphological sib txawv ntawm cov kab mob thiab tsis-pathogenic Escherichia.

Oleg Savitsky sau ntawv 03 Apr, 2017: 217

Ua tsaug rau koj piav txog cov tshuaj uas siv hauv peb thaj av rov qab. Detemir, nws hloov tawm, tsis yog insulin txhua. Xyuas nws tawm. Yog tias koj ntxig cov ntawv sau txog cov tshuaj insulin niaj hnub hauv koj cov kev tshaj tawm, TSIS TXHOB sau nws nrog "fwj", thiab tsis txhob sawv nrog lub koob txhaj tshuaj, tsis txhob qhia. Cov no yog cov duab zoo tib yam ntawm 20 xyoo dhau los, thiab qab zib kuj tseem pleev xim rau. Los ntawm txoj kev, thaum koj yuav piav qhia lub ntsej muag glucometer, nco ntsoov tias nws zoo dua los hno ntiv tes "ntawm sab", thiab tsis ncaj qha rau hauv ncoo, zoo li koj tau ua hauv daim duab dhau los. Rau ntau tshaj 10 xyoo ntawm kev siv, Lantus tsis tau ntsib nws lub raj mis lub raj mis, qhov no yog "xyoo pua kawg". Daim ntawv tso tawm - daim duab cartridges ntawm 300 units, lossis, raws li txoj cai, SoloStar syringe cwjmem. Hauv Orel, Lantus tso li cas? Nyob rau hauv dav dav, Lantus thiab qhov no Levemir, pom, yog twb qub, "lawv" "muaj" ntxiv cov npe nrog cov tshiab, zoo dua, zoo xws li cov tshuaj zoo sib xws. Sau ntawv zoo dua txog kev kho kab mob ntshav qab zib niaj hnub hauv xov tooj los yog hais txog shamanism hauv zos thiab kev ua kom muaj txiaj ntsig zoo. Thov cais qhov sib txawv ntawm cov ntshav qab zib, tsawg kawg 1 thiab 2.

Elena Antonets sau ntawv 03 Lub Plaub Hlis, 2017: 219

Qhov sib ntxiv me me rau cov ntawv

Kuv twb tau piav qhia txog ntawm qhov teeb meem no https://moidiabet.ru/blog/zame…

Yog li ntawd, Kuv theej tawm kuv cov lus augmented me ntsis.

Nyob rau theem no hauv kev txhim kho tshuaj, txhua yam HUMAN GENE-ENGINEERING insulins tau los ntawm kev tsim kho caj ces thiab tsim los rau peb los ntawm E. colli E. coli lossis Saccharomyces cerevisiae poov xab, uas "hloov" ntawm DNA tau hloov mus rau tib neeg. Kuv piav qhia qhov no rau koj ntau yam kwv yees. Leej twg saib xyuas, nyeem hauv is taws nem, zoo, tsawg kawg ntawm no http: //pandia.ru/text/80/138/5 ...
Lo lus "analogue" hauv Lavxias yog "zoo sib xws hauv qee yam." Yog li, hais txog insulins, ANALOGUES yog tib neeg cov insulins uas tau hloov pauv cov qauv ntawm cov qauv molecule. Cov no suav nrog:

1. ULTRA-SHORT insulins, sib txawv hauv qhov pib sai dua thiab lub sijhawm ua haujlwm luv. Nov yog:

HUMALOG (lispro) - cov amino acids nyob hauv chaw 28 thiab 29 ntawm insulin B-cov saw yog sib hloov hauv tib neeg inulin cov roj ntsha.

NOVORAPID (aspart) hauv cov qauv ntawm cov tshuaj insulin ntawm tib neeg, cov amino acid proline ntawm txoj haujlwm B28 yog hloov los ntawm aspartic acid.

APIDRA (glulisin) - nyob rau hauv tib neeg cov tshuaj insulin molecule, cov amino acid asparagine hauv txoj haujlwm B3 yog hloov los ntawm lysine, thiab lysine hloov los ntawm glutamic acid nyob rau hauv txoj haujlwm B29, uas ua rau kom sai dua kev nqus ntawm cov tshuaj.

2. Cov insulins ntev ntev (tsis muaj kev sib cav ntawm tib neeg cov kua dej). Nov yog:

LEVEMIR (detemir) yog tsim los ntawm cov khoom siv DNA biotechnology uas siv cov tshuaj lim ntawm Saccharomyces cerevisiae. Nws yog cov soluble basal analogue ntawm tib neeg ntev-ua yeeb yam insulin nrog ib tiaj tiaj kev ua ub no. Lub sijhawm ua haujlwm ntev ntawm cov tshuaj Levemir® FlexPen® yog vim qhov tshaj tawm tus kheej kev koom tes ntawm detemir insulin lwg me me ntawm qhov chaw txhaj tshuaj thiab qhov khi ntawm cov tshuaj lwg me me rau albumin los ntawm kev sib txuas nrog kev sib txuas ntawm cov roj fatty acid (saib cov lus qhia ntawm nom tswv).

LANTUS (glargine) yog ib qho duab ntawm cov tshuaj insulin uas tau los ntawm kev rov tso cov kab mob DNA ntawm hom Escherichia coli (hom K12). Glulin insulin yog tsim los ua ib qho piv txwv ntawm tib neeg cov insulin, cim los ntawm qis qis solubility hauv qhov chaw nruab nrab. Nyob rau hauv kev sib xyaw ntawm cov tshuaj Lantus® nws yog cov ua kom tiav, uas tau ua los ntawm cov tshuaj tiv thaiv acid ntawm kev daws rau kev txhaj tshuaj (pH 4). Tom qab kev qhia txog cov roj ntsha subcutaneous, cov kua tshuaj acidic yog nruab nrab, uas ua rau cov microprecipitate, los ntawm cov tshuaj insulin glargine tsawg tas li, tso tawm kom paub tseeb, du (tsis muaj peaks) profile ntawm qhov nkhaus "sijhawm sijhawm", Zoo li lub sijhawm ntev ntawm cov yeeb tshuaj (saib cov lus qhia ntawm nom tswv). Qhov nruab nrab ntawm kev nqis tes yog 24 teev, qhov siab tshaj yog 29 teev.

TUJEO Solo Lub Hnub Qub (tib lub glargine, tsuas yog ntawm qhov siab ntawm 300 IU hauv 1 ml). Kuv yuav qhia koj txog nws cais: vim tias qhov kev mob siab zoo li no, tom qab kev tswj hwm subcutaneous, Tujeo tsim cov ntaub ntawv me me ntau dua nrog cov khoom siv txo qis (piv rau 100ME / ml glargine), yog li ntawd Tujeo maj mam thiab ntev ntev tau muab zais los ntawm cov khoom xa mus rau hauv cov hlab ntshav thiab muaj ntau duatiaj»Kev txiav txim siab profile piv rau Lantus. Ntev ntawm Tujeo - mus txog 36 teev.

3. TRESIBA FLEX TACH (degludec) - ib qho piv txwv ntawm tib neeg cov tshuaj insulin SUPERLONGLY ua yeeb yam (ntev txog 40 teev). Tom qab txhaj tshuaj subcutaneous, nws ua rau cov kuab tshuaj lom neeg nyob rau hauv cov subcutaneous depot, los ntawm qhov muaj qhov nruam thiab lub cev ntev ntawm kev nqus ntawm insulin mus rau hauv cov hlab ntshav, muab ib qho ultra-ntev, tiaj profile ntawm kev txiav txim siab thiab ruaj khov hypoglycemic nyhuv ntawm cov tshuaj (saib cov lus qhia raug cai).

Qhov tseeb nthuav))): 1 kg ntawm insulin tuaj yeem tau txais hauv 25 cubic fermenter (bioreactor) siv Escherichia coli, lossis. tawm ntawm 35 txhiab lub taub hau ntawm cov tsiaj ua liaj ua teb, raws li tau ua ua ntej kev txhim kho ntawm kev tsim kho caj ces.

Cov tshuaj lag luam "Levemir"

Txhawm rau kom ua tiav cov kev kho mob siab thaum siv cov tshuaj txiav txim siab, nws yog qhov tseem ceeb uas yuav tsum siv lawv kom raug, soj ntsuam cov caij nyoog noj tshuaj thiab tsis pub dhau lub sijhawm pom zoo ntawm kev kho.

Cov tshuaj insulin Levemir raug kho rau txhua tus neeg mob ib tus zuj zus, nyob ntawm qhov mob hnyav ntawm cov chav kawm ntawm tus kab mob thiab cov yam ntxwv ntawm nws lub cev. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev siv tus kheej tsuas yog tuaj yeem ua rau tus mob hnyav dua, yog li nyob rau hauv cov txheej txheem kev kho, koj yuav tsum ua raws txhua qhov kev pom zoo ntawm tus kws kho mob tsim nyog. Feem ntau Levemir tau sau tseg 1-2 zaug hauv ib hnub. Txawm li cas los xij, ib qho kev hloov kho ntau ntxiv yuav tsum tau yog tias tus neeg mob mob siab rau kev ua haujlwm hauv lub cev lossis tau muaj kev hloov pauv ntawm nws ib txwm noj.

Cob rau "Levemir" raws li kev kho mob monotherapy, thiab hauv kev sib xyaw nrog hypoglycemic cov neeg sawv cev. Lub sij hawm rau kev qhia ntawm cov tshuaj insulin ntev ntev yuav ua tau yooj yim rau tus neeg mob.Txawm li cas los xij, yav tom ntej nws yog ib qho tseem ceeb kom ua raws li lub sijhawm tsim los ntawm thawj qhov txhaj tshuaj. Cov neeg mob ntshav qab zib uas xav tau hloov mus rau Levemir los ntawm lwm hom insulin yuav tsum tshuaj xyuas qhov ntau npaum thiab ua tib zoo saib cov ntshav qab zib thaum lub sijhawm hloov mus.

Tshuaj Noj Lantus

Rau kev siv cov tshuaj "Lantus" cov koob txhaj tshuaj tshwj xeeb yog xav tau. Ua ntej txoj kev kho, nws yog ib qho tseem ceeb yuav tau nyeem lawv cov lus qhia thiab tsis txhob yuam kev los ntawm cov lus pom zoo ntawm cov khw. Yog daim phwj syringe tawm ntawm kev txiav txim, nws yuav tsum tau muab pov tseg thiab ib yam khoom tshiab coj. Koj tuaj yeem kos cov tshuaj los ntawm daim cartridges mus rau hauv cov koob txhaj tshuaj uas tsim tshwj rau kev qhia ntawm insulin, thiab ua ib qho kev txhaj tshuaj. Cov tshuaj yog muab ib hnub ib zaug, nruj me ntsis thaum tib lub sijhawm. Qhov ntau thiab qhov ntev ntawm cov chav kawm raug xaiv ib tus zuj zus rau tus neeg mob. Nws yog tsim nyog sau cia tias yog tias tom qab noj mov cov ntshav qab zib cov ntshav ntau dua qhov kev txiav txim siab ntawm cov neeg noj qab haus huv los ntawm ntau dua 0.6 mmol / l, ces tus kws kho mob yuav muab tshuaj ntxiv luv luv ua ntej noj mov.

Cov kev thaiv tsis zoo thiab cov tshwm sim

Txhawm rau txiav txim siab uas zoo dua: "Lantus" lossis "Levemir", nws yog qhov tsim nyog los sib piv lub xub ntiag ntawm cov ntsiab lus txwv tsis pub siv ib yam tshuaj. Yog li, "Lantus" tsis pom zoo rau kev siv los ntawm cov neeg uas muaj kev cuam tshuam tsis zoo rau nws cov khoom siv. Tsis muaj tshuaj kho mob rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, thiab cov poj niam xeeb menyuam. Cov tshuaj "Levemir" muaj tib qhov kev txwv rau kev siv raws li nws qhov sib piv ntawm cov khoom noj khoom haus.

Qhov sib txawv ntawm Levemir thiab Lantus yog kev qhaj ntawv thiab qhov no tsis yog qhov xav tsis thoob, vim tias lawv ua tib txoj haujlwm kho tib yam. Zoo ib yam li tshuaj noj thiab phiv. Thaum siv cov tshuaj no, tus neeg mob yuav ntsib teeb meem yam tsis xav tau:

txo hauv cov ntshav qabzib,
pom kev pom
Quincke's edema,
o ntawm qhov chaw txhaj tshuaj,
atrophy ntawm subcutaneous rog,
sodium khaws cia hauv lub cev,
tshee hnyo
kev xav ntawm kev ntxhov siab
qaug zog,
pallor ntawm cov epidermis,
kev tshee
kev tsis zoo
xeev siab
lub plawv dhia,
mob taub hau
txos cov ntshav siab
ua pa nyuaj.

Rov qab rau cov lus txheej txheem

Cov kws kho mob tsis muaj kev pom zoo rau ib qho ntawm cov tshuaj uas siv tau zoo dua. Qee qhov kev tshawb fawb tau pom tias Levemir ua rau pom cov suab thaj txo cov nyhuv ntau dua li Lantus. Txawm li cas los xij, kev tswj hwm ntshav plasma qhov tseem ceeb muab los ntawm Levemir thiab Lantus tau zoo ib yam. Thiab ntxiv rau, nyob nruab nrab ntawm cov tshuaj no nyob rau tib theem yog qhov kev pheej hmoo ntawm hypoglycemia. Hauv kev hais txog qhov no, koj tsuas tuaj yeem nrhiav pom tias cov tshuaj twg zoo tshaj plaws rau kev kho mob ntshav qab zib mellitus tom qab kuaj ib qho thiab tshuaj thib ob ntawm koj tus kheej.

Nws puas tseem zoo li tsis tuaj yeem kho ntshav qab zib?

Kev txiav txim los ntawm qhov tseeb tias koj tab tom nyeem cov kab no tam sim no, ib qho kev yeej ntawm kev tawm tsam cov ntshav qab zib hauv ntshav tsis nyob ntawm koj sab.

Thiab koj puas tau xav txog tsev kho mob? Nws yog kev nkag siab, vim tias ntshav qab zib yog ib qho txaus ntshai heev, uas, yog tias tsis kho, yuav ua rau muaj kev tuag. Kev nqhis dej ib txwm, tso zis ceev ceev, qhov muag plooj. Tag nrho cov tsos mob no yog paub txog koj tus kheej.

Tab sis nws puas tuaj yeem kho qhov laj thawj ntau dua li cov nyhuv? Peb pom zoo kom nyeem ib tsab xov xwm txog kev kho mob ntshav qab zib tam sim no. Nyeem kab lus >>

Yuav ua li cas hloov ntawm Lantus mus rau Levemir

Ob leeg Levemir thiab Lantus yog cov piv txwv ntawm tib neeg cov kua dej, uas muaj qhov sib txawv me me ntawm lawv tus kheej, qhia hauv lawv qhov kev nqus qeeb.

Yog hais tias tus neeg mob tau xav paub yuav hloov los ntawm Lantus mus rau Levemir, tom qab ntawd nws raug nquahu kom ua qhov no tsuas yog kev saib xyuas ntawm tus kws kho mob thiab suav txog tus neeg mob txoj kev ua neej, nce lossis nruab nrab kev ua si.

Yuav ua li cas lub neej noj qab nyob zoo nrog hom ntshav qab zib 2

Ntshav qab zib yog ib txoj kev ntawm lub neej. Txhua yam kab mob yog yam tsis tuaj yeem kho. Cov neeg mob yuav tsum muaj theem ntawm lawv lub neej tag nrho ...

Ob qho tshuaj puav leej sawv cev rau ib tiam tshiab ntawm insulin. Ob qho tshuaj tau muab rau cov neeg mob uas muaj hom 1 thiab ntshav qab zib hom 2, ib zaug txhua 12-24 teev los tswj cov qib qab zib yuav tsum muaj.

Cov tshuaj no tsuas yog siv subcutaneously, lwm txoj kev tuaj yeem ua rau txoj kev loj hlob ntawm glycemic coma.

Thaum kho, Lantus yog tswj hwm nruj me ntsis ntawm qee cov xuaj moos ib zaug, soj ntsuam qhov ntau npaum li cas, vim tias cov tshuaj muaj cov nyhuv ntev heev. Nws yog nruj me ntsis txwv tsis pub sib xyaw Lantus nrog lwm hom tshuaj insulin lossis tshuaj yeeb. Txoj kev kho yuav tsum ua raws li cov lus pom zoo los ntawm cov kws kho mob thiab hauv qab kev saib xyuas ntawm tus kws kho mob.

Nta

Glargin - insulin, uas yog ib feem ntawm Lantus, yog qhov qog ntawm tib neeg cov tshuaj hormones thiab yaj nyob hauv ib puag ncig nruab nrab tau ntev.

Kev tsis sib xyaw nrog lwm cov tshuaj yuav tsis raug coj los txiav txim thaum kho mob rau cov neeg mob uas kuaj pom tus mob ntshav qab zib hom 2 mob ntshav qab zib. Hauv qhov no, nws tuaj yeem ua ke nrog qee cov tshuaj hauv qhov ncauj.

Tus neeg xav tau cov tshuaj insulin tsawg

Lub raum khiav tsis zoo. Feem ntau pom nyob rau hauv cov neeg laus laus thiab yog vim li cas rau qhov txo qis hauv tshuaj insulin.
Cov neeg mob muaj kab mob siab. Hauv pawg neeg ntawm cov neeg mob no, muaj qhov txo cov gluconeogenesis thiab lub cev tsis muaj zog insulin metabolism, vim qhov kev xav tau rau qhov hormone tsawg zuj zus.

Cov lus qhia rau kev siv

Cov tshuaj yog muab tshuaj subcutaneously rau cov neeg mob laus dua rau xyoo. Kev txhaj tshuaj ib zaug yog muab ib hnub ib zaug hauv lub plab, lub duav lossis lub xub pwg. Nws raug nquahu kom hloov thaj chaw ntawm daim ntawv thov nrog txhua cov lus qhia ntxiv. Kev tswj hwm ntawm cov tshuaj tiv thaiv yog raug txwv tsis pub siv, vim tias muaj kev pheej hmoo ntawm kev tsim mob hnyav ntawm kev mob ntshav qab zib.

Thaum hloov los ntawm kev kho mob qhov twg lwm cov tshuaj tiv thaiv kab mob tau siv, kho kev kho mob concomitant, nrog rau cov koob tshuaj basal insulin, yog ua tau.

Txhawm rau tiv thaiv qhov tshwm sim ntawm hypoglycemia, qhov koob tshuaj raug txo los ntawm 30% hauv thawj lub hlis ntawm kev kho mob. Nyob rau lub sijhawm no, nws raug nquahu kom nce qhov koob tshuaj tiv thaiv luv luv ua yeeb yam kom txog thaum lub sijhawm hloov.

Nws yog nruj me ntsis txwv tsis pub sib xyaw lossis zom Lantus nrog lwm cov tshuaj. Qhov no yog fraught nrog kev hloov hauv lub sijhawm ntawm kev ua ntawm glargine thiab tsim ntawm sedimentary tshwm sim. Nyob rau thawj lub sijhawm ntawm kev siv tshuaj tshiab, nws yog qhov tsim nyog los tswj cov qib ntawm cov piam thaj hauv cov ntshav.

Sab sij huam

Cov kev mob tshwm sim loj tshaj plaws ntawm kev kho nrog kev siv cov tshuaj Lantus yog kev txhim kho hypoglycemia.

Txawm li cas los xij, muaj ntau qhov tsis zoo thiab tsis tshwm sim ntau ntawm kev noj Lantus:

myalgia
bronchospasm
urticaria
retinopathy
lipoatrophy,
lipohypertrophy,
tsis pom kev
anaphylactic kev poob siab,
Quincke's edema,
o ntawm thaj chaw txhaj tshuaj.

Nws yuav tsum tau yug hauv siab tias yog tias ib qho ntawm cov xwm txheej no tshwm sim, koj yuav tsum sab laj tus kws kho mob tam sim ntawd los kho qhov kev kho mob. Lub caij nyoog ntev ntawm cov tsos mob tshwj xeeb tshaj yog fraught nrog kev puas tsuaj rau cov leeg lossis cov kev puas tsuaj ntawm tus neeg mob mus txog thaum tuag.

Puas yuav muaj peev xwm tuag vim mob ntshav qab zib

Ntshav qab zib mellitus yog cov kab mob endocrine feem ntau. Nov yog kab mob tuag taus. Txog rau hnub tim…

Vim li cas thiaj yuav tsum muaj insulin ntev

Xav ntev ntev insulin Lantus, Levemir lossis Protafan xav tau txhawm rau tswj cov suab thaj kom ceev. Ib qho me me ntawm cov insulin kis rau hauv tib neeg cov ntshav txhua lub sijhawm. Qhov no yog hu ua keeb kwm yav dhau los (theem pib) ntawm insulin. Qhov ua tiav ntawm cov voos insulin txuas ntxiv, 24 teev nyob rau ib hnub. Tsis tas li ntawd, nyob rau hauv kev teb rau ib pluas noj, nws kuj ntxiv ntxiv qhov cuam tshuam loj ntawm insulin rau hauv cov ntshav. Qhov no hu ua bolus koob tshuaj lossis bolus.

Boluses nce insulin concentration rau lub sijhawm luv luv. Qhov no ua rau nws muaj peev xwm tua cov piam thaj kom sai sai uas tau tshwm sim vim yog cov khoom noj los ntawm cov khoom noj. Hauv cov neeg mob uas muaj mob ntshav qab zib hom 1, tus txiav tsis tsim ua cov insulin basal lossis bolus insulin. Kev siv tshuaj insulin ntev ntev muab cov tshuaj insulin tom qab, qhov qis ntawm cov tshuaj insulin. Nws yog ib qho tseem ceeb uas lub cev tsis "zom" nws cov protein thiab tsis tshwm sim ketoacidosis uas muaj ntshav qab zib.

Vim li cas thiaj txhaj tshuaj insulin Lantus, Levemir lossis protafan:

Ua kom yoo ntshav qab zib txhua lub sijhawm thaum nruab hnub, tshwj xeeb thaum sawv ntxov.
Txhawm rau tiv thaiv tus mob ntshav qab zib hom 2 hloov mus ua hom mob ntshav qab zib hom 1.
Nrog ntshav qab zib hom 1 - khaws ib feem ntawm cov qe ntshav kom ciaj sia, tiv thaiv cov txiav ua leeg.
Tiv thaiv kev mob ntshav qab zib ketoacidosis yog ib qho mob hnyav, txo tus mob hnyav.

Lwm lub hom phiaj ntawm kev kho mob ntshav qab zib nrog cov insulin ntev mus yog tiv thaiv kev tuag ntawm qee cov kab mob pancreatic beta hlwb. Kev hno ntawm Lantus, Levemir lossis Protafan txo qis kev thauj ntawm lub txiav. Vim tias qhov no, tsawg dua cov qe hlwb tuag, ntau dua ntawm lawv tseem muaj sia nyob. Txhaj tshuaj ntxiv ntawm cov insulin thaum hmo ntuj thiab / lossis thaum sawv ntxov yuav muaj feem ntau uas cov ntshav qab zib hom 2 yuav tsis nkag mus rau tus mob ntshav qab zib hom 1 loj dua. Txawm hais tias rau cov neeg mob uas muaj ntshav qab zib hom 1, yog tias ib feem ntawm cov qe ntshav tuaj yeem khaws cia kom ciaj sia, chav kawm ntawm tus kab mob txhim kho. Qab zib tsis hla, ua stably nyob ze rau ib txwm.

Cov insulin ntev ntev tau siv rau lub hom phiaj sib txawv dua li kev siv lub tshuab insulin ua ntej noj mov. Nws tsis yog npaj ua rau ziab kom cov ntshav qab zib kom ntshav sai tom qab noj mov. Thiab, nws yuav tsum tsis txhob siv kom sai qab zib cov piam thaj yog tias nws cia li nce hauv koj siab. Vim tias ntev insulin kuj qeeb dhau rau qhov ntawd. Txhawm rau nqus cov zaub mov uas koj noj, siv cov insulin luv luv lossis ultra-luv. Tib yam mus rau sai sai nqa cov piam thaj kom siab.

Yog tias koj sim ua dab tsi txuas ntxiv ntawm cov insulin yog rau ncua sij hawm nrog insulin, qhov tshwm sim ntawm kev kho mob ntshav qab zib yuav ua rau neeg txom nyem heev. Tus neeg mob yuav muaj kev nce ntxiv hauv cov ntshav qab zib, uas ua rau mob nkees ntev thiab mob ntshav siab. Hauv ob peb xyoos, cov teeb meem loj yuav tshwm sim uas yuav ua rau tus neeg xiam oob khab.