Lozap AM > Kev khomob thiab kev tiv thaiv

Hypersensitivity rau ib yam ntawm cov tshuaj.

Cev xeeb tub thiab lub sijhawm pub mis niam.

Lub hnub nyoog txog 18 xyoo (qhov ua tau zoo thiab kev nyab xeeb ntawm kev siv tsis tsim).

Siv tib lub sij hawm nrog aliskiren los yog aliskiren-muaj cov tshuaj nyob hauv cov neeg mob ntshav qab zib mellitus thiab / lossis ua rau lub raum tsis ua haujlwm (GFR tsawg dua 60 ml / min / 1.73 m2) (saib KEV COJ LOSSIS RAU LWM YAM).

Kev ua rau lub siab ua haujlwm tsis zoo (tsis muaj kev paub txog kev siv).

Sab laug ventricular outflow cov lus qhia thaiv kev (xws li, mob aortic stenosis).

Hemodynamically tsis khov kho lub plawv tsis ua haujlwm tom qab mob myocardial infarction.

Siv rau hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm (creatinine tshem tawm tsawg dua 20 ml / min) lossis cov neeg mob ntawm hemodialysis.

Pharmacological kev txiav txim

Cov ntsiav tshuaj ntawm cov tshuaj muaj ob qho kev ua haujlwm hauv kev sib xyaw ntawm Lozap AM nrog lub cev sib xyaw ntawm kev nqis tes ua kom txhim kho cov ntshav siab (BP) tswj hwm rau hauv cov neeg mob ntshav arterial hypertension (AH): potassium losartan, tus mob angiotensin II receptor antagonist (ARA II), thiab amlodipine, tus blocker ' qeeb 'calcium channels (BMCC).

Sab sij huam

Los ntawm lub paj hlwb tawg

Muaj kev tiv thaiv: tsis muaj zog, tsis xis nyob hauv thaj chaw hauv siab, mob hauv siab, hnov zoo sai sai, muaj qhov tsis meej.

Los ntawm cov mob hauv plab zom mov

Muaj kev nyuaj siab: muaj qhov tsis xis nyob hauv plab, dyspepsia, xeev siab, tsis mob ntsws es mob plab.

Ntawm feem ntawm daim tawv nqaij thiab cov nqaij mos

Muaj kev kis: mob khaus khaus (txhais lus), mob urticaria (qhov dav dav).

Ntawm lub plawv

Cuam tshuam: palpitations.

Los ntawm cov hlab ntsha

Muaj kev txhaj tshuaj: yaug ntsej muag, ntshav txha caj qaum.

Los ntawm lub tshuab ua pa, hauv siab thiab mediastinal plab hnyuv siab raum

Hnov khoom nruab nrog thiab lub labyrinthine cuam tshuam

Los ntawm ob lub raum thiab lub plab

Cov lus qhia tshwj xeeb

Hauv cov neeg mob uas txo qis BCC (piv txwv li, tau txais kev kho mob nrog kev kho mob ntau npaum li cas ntawm qhov tshuaj tiv thaiv kab mob) lossis mob aortic stenosis, mob tshwm sim ntawm txoj hlab ntsha o tuaj yeem tshwm sim. Kev kho ntawm cov mob no yuav tsum tau nqa tawm ua ntej teem caij Lozap AM lossis pib kho nrog qhov qis dua ntawm qhov tom kawg.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj: biconvex, oblong, ntau npaum 5 mg + 50 mg - yuav luag dawb lossis dawb, ntawm ib sab nrog kev txua "AT1", ntau npaum 5 mg + 100 mg - xim paj yeeb lossis daj ntseg liab, ntawm ib qho ntawm ob sab sau nrog "AT2" (10 pcs. hauv ib lub hlwv, 300 pcs. hauv lub raj mis yas, hauv ib daim ntawv qhwv 1 los yog 3 lub hlwv, lossis 1 lub raj mis thiab cov lus qhia siv Lozap AM).

1 ntsiav tshuaj muaj:

cov tshuaj nquag: amlodipine camsylate - 7.84 mg (uas yog sib npaug ntawm amlodipine hauv ib qho ntawm 5 mg), potassium losartan - 50 mg lossis 100 mg,
cov khoom siv ntxiv: sodium carboxymethyl hmoov txhuv nplej siab, butylhydroxytoluene, microcrystalline cellulose, povidone K30, mannitol, magnesium stearate, crospovidone,
zaj duab xis lub tsho tiv no: hyprolose, talc, hypromellose, titanium dioxide, ntxiv rau qhov muab ntau npaum li 5 mg + 100 mg - dyes hlau oxide daj thiab hlau oxide liab.

Cov Tshuaj Hauv Tshuaj

Lozap AM - yog cov tshuaj tiv thaiv hypotensive ua ke uas suav nrog qeeb calcium calcium blocker (BMCC) thiab angiotensin II receptor antagonist (ARA II). Raws li cov txiaj ntsig ntawm kev tshawb fawb uas cov neeg ua haujlwm noj qab haus huv tau koom nrog, Lozap AM hauv kev noj tshuaj ntawm 5 mg + 50 mg thiab 5 mg + 100 mg yog zoo sib xws rau kev siv cov tshuaj sib xyaw ntawm amlodipine camsylate thiab losartan potassium li cais npaj.

Nws kuj tau pom tias Lozap AM ntsiav tshuaj, nyob rau hauv uas amlodipine camsylate muaj nyob rau hauv ib koob tshuaj 5 mg, yog cov sib npaug rau amlodipine besilate ntsiav tshuaj hauv tib lub koob tshuaj.

Tus txheej txheem ntawm kev coj ntawm cov tshuaj Lozap AM

Cov nquag ua haujlwm ntawm Lozap AM - amlodipine (BCC) thiab losartan (ARA II) muaj cov kev ua haujlwm ntawm kev ua haujlwm txhawm rau ntxiv dag zog rau cov ntshav siab (BP) tswj hauv cov neeg mob ntshav siab (AH). Losartan inhibits vasoconstrictor nyhuv ntawm angiotensin II thiab qhov kawg-tso lus tawm ntawm aldosterone los ntawm kev xaiv yam inhibiting qhov khi ntawm angiotensin II rau AT receptors₁Cov. Amlodipine hais txog cov vasodilators ntawm cov hlab ntsha peripheral thiab ua rau cov leeg ntawm cov leeg ntawm cov hlab ntshav, uas ua rau lub cev tsis muaj zog ntawm lawv qhov kev tawm tsam thiab qhov kev txo qis ntshav siab.

Angiotensin II tso rau pom muaj zog vasoconstrictor (vasoconstrictive) muaj txiaj ntsig, thiab yog lub cev tseem ceeb ntawm cov renin-angiotensin-aldosterone system (RAAS) thiab tseem ceeb pathophysiological rau kev kub siab. Muab khi rau AT receptors₁nyob hauv cov nqaij hauv cov nqaij leeg ntawm cov hlab ntshav, cov raum, cov qog adrenal thiab lub plawv, angiotensin II muab vasoconstriction thiab tso tawm aldosterone rau hauv cov hlab ntshav. Tsis tas li, cov tshuaj hormones no ua rau kev loj hlob ntawm cov leeg hlwb ntawm lub cev.

Losartan, tus tswvcuab ntawm pawg xaiv cov tsis sib xws ntawm ARA II (AT₁receptors), ua kom pom kev ua tau zoo thaum coj qhov ncauj. Qhov tshuaj yeeb dej caw no thiab nws cov carboxylated metabolite (E-3174) hauv vitro thiab hauv vivo tshem tawm txhua qhov cuam tshuam tseem ceeb ntawm angiotensin II, tsis hais txog txoj hauv kev lossis qhov chaw ntawm nws cov synthesis. Losartan xaiv xyoob khi rau AT₁-xaj khoom siv, thaum nws tsis khi lossis khi txoj kev txais ntawm lwm cov tshuaj hormones thiab ion channel uas tswj cov kev ua haujlwm ntawm cov hlab plawv (CCC). Tsis tas li, cov haujlwm tivthaiv tsis cuam tshuam rau kev ua haujlwm ntawm angiotensin hloov enzyme (ACE) - kininase II, uas inactivates bradykinin. Yog li, cov nyhuv ntawm losartan tsis muaj feem xyuam rau cov cuam tshuam ncaj qha los ntawm AT thaiv.₁receptors (nrog rau qhov pom ntawm edema).

Amlodipine yog ib qho kev tso tawm ntawm dihydropyridine, ib qho kev tawm tsam ntawm calcium ions lossis BMCC, tiv thaiv cov transmembrane nkag ntawm calcium ions rau hauv cardiomyocytes thiab cov leeg nqaij vascular. Nws tuaj yeem xav tau ntawm lub hauv paus ntawm kev sim cov ntaub ntawv uas cov khoom no tuaj yeem khi ntawm cov chaw txais ntawm cov calcium qeeb nrog dihydropyridine thiab tsis-dihydropyridine cov chaw sib khi. Amlodipine xaiv yam tshuaj tiv thaiv kev ntws los ntawm cov calcium los ntawm cov qog ua rau muaj mob, cuam tshuam rau cov leeg hlwb pob qog ntau dua li myocardial hlwb. Cov quav tsis cuam tshuam txog qib calcium uas nyob hauv cov ntshav.

Losartan, zoo li amlodipine, txo qis ntshav siab vim qhov kev qaug zog ntawm kev tiv thaiv peripheral. Kev txwv tsis pub nkag mus ntawm cov calcium rau hauv lub cell thiab txo cov nyhuv vasoconstrictor tshwm sim los ntawm cov kev ua ntawm angiotensin II yog cov kev ua haujlwm sib xyaw.

Losartan (ntxiv cov teeb meem tshuaj ntxiv)

Losartan inhibits qhov nce ntxiv ntawm systolic (DBP) thiab diastolic (dAD) ntshav siab vim yog ua rau txoj kev lis ntshav ntawm angiotensin II. Thaum ncav cuag qhov siab tshaj plaws kev xav tau (C_max) losartan nyob rau hauv cov ntshav tom qab noj ib koob tshuaj 100 mg, cov txiaj ntsig saum toj no ntawm angiotensin II yog raug kev cuam tshuam los ntawm kwv yees li 85%, thiab tom qab 24 teev - los ntawm 26-39%, feem, tom qab siv ib lossis ntau koob.

Kev txwv ntawm renin ntau lawm los ntawm angiotensin II (cov lus pom tsis zoo), tshem tawm los ntawm losartan, ua rau muaj kev nce ntxiv hauv cov ntshav plasma renin (ARP) kev ua, uas ua rau muaj kev nce ntxiv hauv plasma angiotensin II qib. Thaum lub sijhawm 6 lub lis piam kev noj tshuaj 100 losartan hauv cov neeg mob ntshav siab thaum lub sijhawm C ncav cuag_max muaj kev nce ntxiv hauv cov ntshav concentration ntawm angiotensin II los ntawm 2-3 zaug, thiab hauv qee qhov xwm txheej siab dua, feem ntau yog nrog cov chav kawm kev kho mob ntawm 14 hnub. Txawm li cas los xij, cov nyhuv antihypertensive thiab txo qis hauv plasma aldosterone ntau tau pom tom qab 2 thiab 6 lub lim tiam ntawm kev kho mob, qhia tias muaj kev cuam tshuam zoo ntawm cov tshuaj angiotensin II. Tom qab qhov txiav ntawm losartan tswj hwm, kev saib xyuas ntawm angiotensin II thiab ARP txo qis dua 3 hnub rau thawj zaug qhov tseem ceeb.

Thaum piv cov kev cuam tshuam ntawm losartan hauv koob tshuaj 20 thiab 100 mg nrog kev cuam tshuam ntawm ACE inhibitor, nws tau pom tias losartan, vim muaj cov txheej txheem tshwj xeeb ntawm kev txiav txim siab, thaiv cov teebmeem ntawm angiotensin I thiab II tsis cuam tshuam rau bradykinin. Ib qho ACE inhibitor suppressed cov lus teb rau angiotensin I thiab nce qhov hnyav ntawm cov teebmeem tshwm sim los ntawm kev ua si bradykinin tsis hloov qhov tsis zoo ntawm cov lus teb rau angiotensin II, uas tau lees tias qhov txawv ntawm pharmacodynamic ACE inhibitors thiab losartan.

Cov nyhuv antihypertensive ntawm losartan, qib ntawm nws thiab nws cov nquag metabolite hauv ntshav nce nrog qhov nce ntawm cov tshuaj. Ob leeg losartan thiab nws cov metabolite nquag muaj qhov cuam tshuam hypotensive.

Raws li cov ntaub ntawv muaj los ntawm kev tshawb fawb hauv cov txiv neej noj qab haus huv tau koom nrog, nrog kev tswj hwm ntawm qhov ncauj ntawm losartan ntawm koob tshuaj 100 mg tiv thaiv kev noj zaub mov kom muaj ntsev ntau thiab cov ntsev qis, cov khoom tsis cuam tshuam rau glomerular filtration rate (GFR), lim ua feem, thiab lub raum ntshav txaus. Losartan pom natriuretic muaj txiaj ntsig, qhov tseem ceeb tshaj plaws nrog kev noj zaub mov ntsev tsawg, thiab tseem ua rau cov neeg tso zis tso zis ntau ntxiv los ntawm lub raum.

Nyob rau hauv muaj cov proteinuria (tsawg kawg 2 g / 24 teev) hauv cov neeg mob ntshav siab, tsis muaj ntshav qab zib, tau txais losartan ntawm ib koob ntawm 50 mg rau 8 lub lis piam nrog maj mam nce ntxiv ntawm cov koob tshuaj txhua hnub rau 100 mg, txo qis proteinuria (los ntawm 42%) tau sau cia, thiab kuj fractional excretion ntawm albumin thiab immunoglobulin G (IgG). Hauv cov neeg mob ntawm cov pab pawg no, qhov ntsuas pom tau tsawg dua thiab GFR tseem ruaj khov.

Cov neeg mob nyob rau lub sijhawm postmenopausal nrog kub siab uas noj 50 mg losartan ib hnub rau 4 lub lis piam tsis tau qhia txog cov nyhuv ntawm cov tshuaj ntawm cov kab ke hauv lub cev thiab cov qog ntawm prostaglandins (PG).

Cov tshuaj noj ua ntej noj mov (ntawm lub plab khoob), nyob rau hauv cov koob tshuaj txhua hnub txog li 150 mg, tsis ua rau thaj chaw kho mob muaj kev hloov pauv tseem ceeb hauv cov concentration ntawm triglycerides, tag nrho cov roj (Chs) thiab Chs qhov siab lipoproteins (HDL), thiab kuj tsis cuam tshuam rau theem ntawm cov piam thaj hauv ntshav. Qhov kev txiav txim ntawm tus neeg sawv cev muab qhov txo qis ntawm cov ntshav ntawm uric acid nyob rau hauv cov ntshav (feem ntau tsawg dua 0.4 mg / dl), uas tseem nyob rau lub sijhawm kho.

Hauv 12 lub lis piam kev tshawb fawb nrog cov neeg mob sab laug ventricular tsis ua haujlwm ntawm II - IV ua haujlwm hauv chav kawm raws li kev faib tawm ntawm New York Association of Cardiology (NYHA) tau txais cov diuretics thiab / lossis mob plawv glycosides, cov nyhuv ntawm losartan hauv koob tshuaj txhua txhua hnub ntawm 2.5, 10, 25 tau muab piv thiab 50 mg nrog cov nyhuv placebo. Cov tshuaj hauv koob tshuaj 25 thiab 50 mg qhia pom tias cov neurohormonal zoo thiab hemodynamic kev ua haujlwm thoob plaws hauv kev tshawb nrhiav. Losartan nce lub plhaw ua piv txwv thiab muaj kev sib tsoo tsis sib luag hauv cov hlab ntsws hlab ntshav, nrog rau qhov tsis muaj zog tag nrho cov hlab ntshav tsis kam (OPSS), poob qis nruab nrab ntawm kev mob ntshav thiab ntshav plawv (HR). Hauv cov neeg mob no, qhov tshwm sim ntawm txoj hlab ntshav hypotension yog koob tshuaj. Cov teebmeem hauv neurohormonal yog kev poob qis hauv cov ntshav ntawm norepinephrine thiab aldosterone.

Amlodipine (ntxiv cov teeb meem tshuaj ntxiv)

Kev siv cov tshuaj amlodipine hauv kev kho mob hauv cov neeg mob ntshav siab ua rau vasodilation, thiab ua rau kom cov ntshav hauv cov ntshav tawm hauv kev dag thiab sawv ntsug. Qhov no hypotensive nyhuv ntawm cov tshuaj nquag tsis yog nrog cov kev hloov pauv tseem ceeb hauv lub plawv lossis ntshav catecholamine ntau ntau nrog kev kho mob ntev. Txawm hais tias ib leeg tso ntshav (iv) kev tswj hwm ntawm amlodipine qhia tau txo qis ntshav siab thiab nce siab hauv lub plawv thaum kawm, rov hais dua cov thawj coj ntawm cov tshuaj tsis ua rau muaj kev hloov pauv hauv lub plawv lossis ntshav siab hauv cov neeg mob ntshav siab thiab nrog angina pectoris.

Tawm tsam keeb kwm ntawm qhov ncauj ntev ntawm kev tswj hwm ntawm amlodipine ib zaug ib hnub, nws cov nyhuv antihypertensive raug pom tsawg kawg 24 teev. Plasma theem ntawm cov tshuaj uas muaj sia hauv cov ntshav cuam tshuam nrog cov nyhuv hypotensive rau ob leeg hluas thiab cov neeg laus laus. Qhov ntsuas kev txo qis ntshav siab thaum siv amlodipine kuj tseem cuam tshuam nrog qhov loj ntawm nws qhov nce nce pom ua ntej kev kho mob. Hauv cov neeg mob DBP 105–114 hli Hg. Kos duab. (AH ntawm mob hnyav) ib qho tshuaj tiv thaiv kev tiv thaiv kab mob siab pom tau kwv yees li 50% ntau dua qhov ntawd hauv cov neeg mob DBP ntawm 90-104 hli Hg. Kos duab. (AH ntawm mob hnyav). Hauv cov neeg ib txwm ntshav siab nyob hauv cov neeg mob, nws qhov kev hloov pauv tseem ceeb tsis tau sau cia.

Hauv cov neeg mob ntshav siab tiv thaiv keeb kwm yav dhau los ntawm kev ua haujlwm hauv lub raum, cov thawj coj ntawm amlodipine hauv kev kho mob tsis muaj zog tiv thaiv kev tawm tsam ntawm cov hlab ntsha ntawm lub raum, nce ntxiv ntshav tawm ntshav txaus thiab nce GFR, tsis tas hloov cov lim feem lossis proteinuria.

Hauv cov neeg mob noj tshuaj amlodipine, nrog kev ua haujlwm ventricular ib txwm, hemodynamic tsis tau ntawm lub siab thaum so thiab thaum qoj ib ce pom qhov tsis txaus siab feem ntau ntawm lub plawv dhia tsis muaj qhov hloov pauv tseem ceeb ntawm kev nce siab hauv qhov pib ntawm cov theem ntawm kev ntiab tawm ntshav hauv cov kab noj hniav ntawm sab laug ventricle, lossis hauv qhov ntim ntawm sab laug ventricle / kawg DBP. Raws li kev ntsuam xyuas ntawm cov hemodynamic, cov tshuaj yeeb dej caw hauv kev siv tshuaj tsis ua rau pom qhov tsis zoo lub zog hauv cov neeg tuaj yeem noj qab haus huv, txawm tias thaum ua ke nrog β-blockers. Nyob rau tib lub sijhawm, cov txiaj ntsig zoo sib xws tau sau tseg hauv cov neeg mob uas muaj lub plawv tsis txaus hauv cov nyiaj them rov qab lossis hauv cov neeg mob noj qab haus huv thaum siv tshuaj nrog qhov tsis zoo inotropic.

Atrioventricular conduction (AV conduction) lossis sinoatrial node muaj nuj nqi hauv cov neeg tuaj yeem noj qab haus huv tsis raug cuam tshuam los ntawm amlodipine. Hauv / hauv kev qhia ntawm cov tshuaj hauv ib koob tshuaj 10 mg nrog cov mob caj dab ntev ruaj khov tsis cuam tshuam AH thiab H-V kev coj ua thiab lub sijhawm rov qab los ntawm lub qhov ntswg ntshav tom qab cov leeg ntshav siab. Cov txiaj ntsig zoo sib xws tau pom nyob rau hauv cov neeg mob noj tshuaj amlodipine sib xyaw nrog β-blockers. Hauv kev tshawb nrhiav hauv cov neeg mob ntshav siab lossis angina pectoris nrog kev tswj hwm ntawm amlodipine nrog β-blockers, qhov kev xav tsis zoo ntawm qhov tsis tau ntawm electrocardiogram (ECG) tsis tau pom. Hauv cov neeg mob uas mob angina pectoris, kev siv tshuaj amlodipine tsis cuam tshuam rau ECG sib nrug thiab tsis ua rau muaj qhov thaiv AV ntau dua.

Cov Tshuaj Pharmacokinetics

Tom qab lub qhov ncauj tswj hwm, nws yog qhov zoo nqus thiab undergoes cov nyhuv ntawm thawj kev nkag mus rau ntawm daim siab nrog kev tsim ntawm ib lub carboxylated metabolite thiab lwm yam kev siv lub cev. Rau losartan nyob rau hauv cov ntsiav tshuaj daim ntawv, ib qho kev qhia txog kev nyab xeeb txog ntawm 33% yog cov yam ntxwv. Losartan thiab nws cov metabolite nquag ncav cuag nruab nrab Cmax qhov tseem ceeb 1 thiab 3-4 teev tom qab kev coj ua, feem. Noj mov tsis muaj kev cuam tshuam loj hauv kev kho mob ntshav ntawm lub plasma concentration profile ntawm cov khoom lag luam.

Nrog cov plasma protein (feem ntau nrog albumin), losartan thiab nws cov nquag metabolite khi tsis pub tsawg dua 99%. Khoom faib ntim (V_d) losartan yog 34 litres. Raws li kev tshawb fawb tsiaj, cov tshuaj nyuaj kis los ntawm cov ntshav-hlwb teeb meem (BBB). Tsis muaj qhov cim tseg nyob rau hauv cov ntshav ntawm losartan thiab nws cov metabolite thaum siv cov tshuaj hauv 100 mg ib zaug ib hnub.Vim yog lub qhov ncauj tswj hwm ntawm losartan hauv koob tshuaj txog 200 mg, qhov tshuaj thiab nws cov nquag metabolite qhia tawm cov tshuaj pharmacokinetics.

Nrog rau iv los yog qhov ncauj siv losartan, li ntawm 14% ntawm nws cov koob tshuaj yog biotransformed rau hauv kev siv tshuaj metabolite. Tom qab lub qhov ncauj tswj hwm lossis kev tswj hwm kev tswj hwm ntawm 14 C ntawm losartan (sau npe nrog cov pa roj carbon radioactive), lub plasma ntshav plasma radioactivity yog feem ntau vim muaj cov losartan thiab cov khoom lag luam nquag ntawm nws cov metabolism. Qhov nruab nrab, 1% ntawm cov neeg tau kawm pom tias muaj kev cuam tshuam me ntsis ntawm kev hloov losartan mus rau hauv kev siv tshuaj tiv thaiv. Ntxiv nrog rau kev tsim cov tom kawg thaum lub sij hawm hloov pauv ntawm losartan, ob lub ntsiab lus hauv biologically tsis muaj zog yog tsim uas tshwm sim vim yog hydroxylation ntawm sab butyl saw, thiab ib theem nrab - N-2-tetrazole-glucuronide.

Lub plasma tshem ntawm losartan thiab nws cov metabolite yog kwv yees li 600 thiab 50 ml / min, thiab lub raum - li 74 thiab 26 ml / min, feem. Thaum noj ntawm qhov ncauj, losartan raug tso tawm los ntawm ob lub raum hauv daim ntawv tsis hloov pauv txog 4% ntawm koob tshuaj thiab hauv daim ntawv tshuaj tiv thaiv kev siv tshuaj - txog 6% ntawm koob tshuaj. Kev sib zog ntawm losartan thiab nws cov metabolite hauv plasma txo qis polyexponentially nrog cov theem kawg ntawm ib nrab-lub neej (T_1/2) kwv yees li 2 thiab 6–9 teev, raws. Losartan thiab nws cov metabolite yog ua rau lub raum thiab dhau los ntawm cov hnyuv nrog cov kua tsib. Tom qab qhov ncauj tswj hwm ntawm losartan 14 C hauv cov txiv neej, qhov nruab nrab ntawm 35% ntawm xov tooj cua tau kuaj pom nyob hauv cov zis thiab 58% hauv quav, tom qab iv kev tswj hwm kwv yees li 43% ntawm radioactivity hauv zis thiab 50% hauv quav.

Kev mob ntshav siab rau cov poj niam, ntshav plasma concentration ntawm losartan yog 2 npaug ntau dua li uas nyob hauv cov txiv neej. Qeb ntshav cov ntshav hauv cov metabolite rau hauv tus txiv neej thiab poj niam zoo tib yam. Txawm li cas los xij, qhov sib txawv ntawm pharmacokinetic no tsis yog qhov tseem ceeb hauv tsev kho mob.

Nrog kev tswj hwm ntawm qhov ncauj ntawm amlodipine hauv kev kho mob kom zoo, nws Cmax pom tom qab 6-12 teev. Kev tsis raug cai ntawm qhov tsis raug cai yog 64-90% ntawm qhov ncauj noj. Lub bioavailability ntawm amlodipine yog ywj siab ntawm kev noj zaub mov.

Thaum lub sijhawm kawm, nws pom tias nyob hauv cov neeg mob ntshav siab yog kwv yees li 93% ntawm ncig amlodipine khi rau cov ntshav protein. Nrog kev siv txhua hnub, cov tshuaj nyob ruaj ruaj (Css) ntawm amlodipine hauv ntshav yog pom tom qab 7-8 hnub.

Kwv yees li 90% ntawm amlodipine yog metabolized hauv daim siab ua rau lub cev tsis muaj zog, txog 10% ntawm cov koob tshuaj tau pom tsis txawv txav los ntawm lub raum, thiab 60% hauv hom tshuaj metabolites.

Amlodipine los ntawm ntshav ntshav yog tshem tawm hauv ob theem, theem kawg T_1/2 tej zaum yuav sib txawv ntawm 30 txog 50 teev.

Lozap AM, cov lus qhia rau kev siv: kev ua thiab npaum li cas

Lozap AM ntsiav tshuaj noj ntawm qhov ncauj, tsis hais lub sijhawm noj mov, muaj dej txaus. Cov tshuaj tuaj yeem siv nrog lwm cov tshuaj tiv thaiv antihypertensive.

Cov neeg mob uas ua tsis tiav kom ua tiav cov ntshav siab tswj hwm thaum siv losartan lossis amlodipine li cov tshuaj monotherapy tuaj yeem hloov mus rau txoj kev kho ua ke ntawm Lozap AM. Siv tshuaj ib zaug hauv ib hnub rau 1 ntsiav tshuaj, qhov ntau tshaj yog 5 + 100 mg ib zaug txhua 24 teev.

Lozap AM 5 + 50 mg tau pom zoo rau cov neeg mob uas tsis ua tiav ntshav siab tswj hwm thaum siv amlodipine ntawm koob tshuaj 5 mg lossis losartan ntawm koob tshuaj 50 mg hauv kev kho mob monotherapy.

Lozap AM 5 + 100 mg tau pom zoo rau cov neeg mob uas tsis ua tiav tswj ntshav siab thaum siv losartan ntawm koob ntawm 100 mg lossis tshuaj Lozap AM 5 + 50 mg. Cov neeg mob uas siv tshuaj amlodipine thiab losartan raws li cais cov tshuaj tuaj yeem hloov mus rau Lozap AM (muaj tib lub sijhawm ntawm amlodipine thiab losartan) kom nce siab ntxiv rau kev kho.

Yog tias noj Lozap AM yog qhov tsim nyog rau cov neeg mob uas txo BCC, nrog lub siab tsis ua haujlwm lossis cov neeg laus, tom qab ntawd pib kho nrog cov tshuaj sib xyaw nrog cov tshuaj amlodipine thiab losartan, ib qho kev xaiv ntawm cov tshuaj ntawm cov tshuaj yeeb dej caw no yuav tsum tau nqa tawm.

Cov neeg mob nrog BCC txo (nrog rau cov neeg tau txais kev kho mob nrog diuretics hauv kev txhaj tshuaj siab) tau pom zoo kom losartan nyob rau hauv thawj zaug ntawm 25 mg ib zaug ib hnub raws li kev kho mob monotherapy, vim tias Lozap AM tsis muaj tshuaj uas suav nrog 25 mg ntawm losartan.

Noj ntau dhau

Nws tsis muaj cov ntaub ntawv hais txog kev siv dhau ntawm Lozap AM.

Cov ntaub ntawv hais txog kev noj tshuaj ntau dhau ntawm losartan muaj qhov txwv, feem ntau yuav nrog qhov mob no, tachycardia thiab cov cim ntshav txo qis yuav tshwm sim, qhov tshwm sim ntawm bradycardia yog ua tau los ntawm kev txhawb nqa parasympathetic. Cov kev kho mob thaum siv tshuaj kho mob, kws kho mob hemodialysis ua tsis tau zoo.

Cov tsos mob ntawm kev noj haus ntau tshaj ntawm amlodipine yuav yog cov hlab ntsha ntau dhau nrog txoj kev txo ntshav siab thiab qhov tshwm sim ntawm cov kab mob reflex tachycardia. Muaj cov ntaub ntawv tshaj tawm ntawm lub sijhawm ntev thiab muaj cov kab mob siab rau lub cev, nrog rau kev poob siab nrog cov txiaj ntsig tuag. Yog hais tias noj ntau dhau, yog tias tsim nyog, ua kom pais plab thiab kom nqus tau cov pa hluav taws. Yog tias kev noj tshuaj ntau dhau heev, yuav tsum tau saib xyuas kev ua pa thiab hemodynamic, thiab feem ntau ntsuas ntshav siab. Tawm tsam keeb kwm yav dhau los ntawm qhov tshwm sim ntawm arterial hypotension, kev tswj hwm ntawm cov kua hauv lub cev yuav tsum ua kom ntseeg tau, tus neeg mob ntawm ceg yuav tsum tau nce thiab lwm yam kev ntsuas yuav tsum tau coj los tswj cov hemodynamics. Yog tias kev txuag tau ua tsis tau zoo, kev tswj hwm ntawm phenylephrine lossis lwm tus neeg sawv cev vasoconstrictor tuaj yeem raug tshuaj, nyob ntawm diuresis thiab bcc.

Qhov thaiv ntawm calcium channel yog tshem tawm los ntawm iv Txoj kev lis ntshav ntawm calcium gluconate. Tus txheej txheem hemodialysis yog qhov tsis muaj txiaj ntsig, vim tias amlodipine muaj qhov siab ntawm kev khi rau cov ntshav protein.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Kev kawm txog qhov tshwm sim ntawm Lozap AM ntawm kev muaj peev xwm tsav tsheb thiab lwm yam txheej txheem nyuaj tseem tsis tau ua. Txawm li cas los xij, nws yuav tsum tau yug los rau hauv lub siab hais tias thaum lub sijhawm kho mob qee qhov kev xav tsis zoo tuaj yeem tshwm sim tuaj yeem cuam tshuam rau kev ceev ntawm psychomotor kev xav thiab kev xav.

Cev xeeb tub thiab lactation

Txais Tos Lozap AM thaum cev xeeb tub thiab thaum lactation yog contraindicated. Cov tshuaj uas cuam tshuam ncaj qha rau RAAS tuaj yeem ua rau muaj kev puas tsuaj thiab tuag mus rau tus me nyuam hauv plab. Thaum kuaj pom kev xeeb tub, cov tshuaj yuav tsum muab tam sim ntawd. Yog tias tsim nyog, hloov mus rau lwm txoj kev kho mob nrog tshuaj uas muaj kev pom zoo kev nyab xeeb rau kev siv thaum cev xeeb tub.

Txawm hais tias cov poj niam cev xeeb tub tsis muaj kev paub txog kev noj Lozap AM, kev tshawb fawb tsiaj ua ntej pom tias losartan tuaj yeem ua rau mob embryonic thiab neonatal raug mob thiab tuag ntawm tus menyuam hauv plab. Nws xav tias cov txheej txheem ntawm cov xwm txheej no cuam tshuam nrog kev cuam tshuam ntawm RAAS.

Kev siv losartan hauv kev txiav thib ob thiab thib peb ntawm kev xeeb tub ua rau mob ntxiv rau kev ua haujlwm ntawm lub raum thiab ua rau muaj qhov tshwm sim thiab tuag ntawm cov menyuam hauv plab thiab cov menyuam yug tshiab. Qhov tshwm sim ntawm oligohydramnios tej zaum yuav cuam tshuam nrog hypoplasia ntawm tus me nyuam hauv plab lub ntsws thiab deformations ntawm nws lub cev pob txha. Cov kev tsis haum lub siab vim losartan hauv cov menyuam yug tshiab yuav suav nrog kev mob ntshav liab, pob txha cranial hypoplasia, mob hlwb, lub raum tsis ua haujlwm, thiab tuag. Yog tias kev kho mob nrog cov tshuaj uas cuam tshuam rau RAAS nyob rau zaum ob thiab thib peb lub sijhawm cev xeeb tub tsis tuaj yeem hloov nrog lwm txoj kev kho, tus neeg mob yuav tsum paub txog kev pheej hmoo ntawm kev siv cov tshuaj no rau cov menyuam hauv plab.

Kev tswj xyuas tau zoo thiab tsim nyog ntawm kev siv amlodipine rau cov poj niam cev xeeb tub tsis tau ua.

Txawm hais tias losartan thiab amlodipine xa mus rau niam cov kua mis tsis paub. Yog tias koj yuav tsum noj Lozap AM lub sijhawm thaum lactation, koj yuav tsum tsis txhob pub mis.

Tsis muaj cov ntaub ntawv ntawm cov nyhuv ntawm losartan ntawm kev muaj me nyuam. Muaj cov ntaub ntawv hais txog cov neeg muaj kev thim rov qab biochemical hloov ntawm cov phev lub taub hau, pom hauv qee cov neeg mob tau txais BMCC. Cov ntaub ntawv soj ntsuam xav tau los ntsuas qhov muaj peev xwm tshwm sim ntawm amlodipine ntawm kev muaj me nyuam tsis txaus.

Siv rau thaum yau

Kev siv Lozap AM hauv cov menyuam yaus thiab cov hluas yog contraindicated, txij li thaum cov neeg mob hnub nyoog qis dua 18 xyoo kev nyab xeeb thiab kev ua haujlwm ntawm kev siv tshuaj tsis tau txhim tsa.

Cov menyuam mos uas lawv niam coj ARA II thaum cev xeeb tub (suav nrog losartan) yuav tsum tau saib xyuas kom zoo los tswj cov ntshav hyperkalemia, oliguria thiab arterial hypotension. Yog tias cov teeb meem saum toj no tau txheeb xyuas hauv cov menyuam yaus no, kev kho mob cov tsos mob tau raug tso cai kom tswj lub plawv rov ua kom zoo nkauj thiab ntshav siab. Yuav tau txhab ntshav rau lub txhab ntshav lossis lim ntshav kom tiv thaiv kev mob ntshav ntawm lub plawv thiab / lossis kom lub raum tsis ua haujlwm.

Nrog lub raum tsis ua haujlwm

Thaum muaj mob raum loj (CC qis dua 20 ml / min) lossis xav tau kev kho mob hemodialysis, noj Lozap AM yog contraindicated. Rau cov neeg mob uas tsis tshua mob raum lub raum kev ua haujlwm, kev kho mob nrog tshuaj tsis pom zoo. Ceev faj yuav tsum tau noj cov tshuaj rau stenosis ntawm ib lub raum leeg los yog ob sab ntawm lub raum mob raum, mob raum tsis ua haujlwm, mob tom qab hloov raum. Nws tsis tas yuav hloov kho qhov koob tshuaj rau cov neeg mob uas ua tsis taus ntawm lub raum kev ua haujlwm hauv CC - 20-50 ml / min.

Nrog lub siab ua haujlwm tsis zoo

Hauv lub siab ua haujlwm tsis zoo (ntau dua li 9 ntsiab lus ntawm Me-Pugh nplai) - Lozap AM yog qhov cuam tshuam, cov neeg mob tsis ua haujlwm lub siab ua haujlwm ntawm qhov mob me thiab mob hnyav (tsawg dua 9 ntsiab lus ntawm Cov Me Nyuam-Pugh teev) yuav tsum siv tus neeg sawv cev tiv thaiv kab mob nrog ceeb toom.

Raws li cov ntaub ntawv pharmacokinetic, uas qhia pom tias muaj ntshav plasma losartan nce ntxiv hauv cov neeg mob uas ua kom mob ntshav siab, tus neeg mob muaj keeb kwm ua mob ntshav siab lossis mob siab rau lub siab tsis ua haujlwm tsis zoo. Lawv xav tau lub sijhawm ntawm losartan hauv kev noj tshuaj qis (25 mg ib hnub ib zaug) hauv kev kho tshuaj monotherapy.

Vim qhov tseeb tias amlodipine feem ntau ua rau lub siab, hauv cov neeg mob uas tsis muaj T_1/2 sib npaug zos rau 56 teev. Yog tias nws yog qhov yuav tsum tau siv amlodipine rau hauv cov neeg mob uas muaj lub siab tsis ua haujlwm siab ntau ntxiv, kev pom zoo ntawm nws cov koob tshuaj tau pom zoo kom maj mam ua.

Siv rau lub sijhawm qub

Thaum ua qhov kev tshawb fawb soj ntsuam hauv cov neeg mob uas muaj hnub nyoog 65 xyoos, tsis muaj qhov pom tau hais txog qhov ua tau zoo thiab kev nyab xeeb los ntawm kev kho tus mob losartan. Txij li thaum nyob hauv cov neeg laus laus, vim tias txo qis ntawm amlodipine, thaj chaw hauv qab cov txheej txheem concentration-sijhawm nkhaus (AUC) nce ntxiv kwv yees li 40-60%, feem ntau pom zoo kom pib noj nws nrog tshuaj txhua hnub ntawm 2.5 mg, tab sis txij li Lozap AM muaj 5 mg ntawm amlodipine, cov neeg mob zoo li no yuav tsum siv tshuaj amlodipine ua lub tshuaj monotherapy.

Yeeb tshuaj sib cuam tshuam

Kev kawm txog kev sib cuam tshuam ntawm Lozap AM nrog lwm cov tshuaj tsis tau ua.

Muaj kev cuam tshuam tshwm sim ntawm kev sib cuam tshuam ntawm losartan nrog kev siv sib txuam nrog lwm cov tshuaj / cov neeg sawv cev:

digoxin, hydrochlorothiazide, cimetidine, warfarin, phenobarbital: tsis muaj kev cuam tshuam tseem ceeb hauv chaw kho mob tau pom,
rifampicin: qib ntawm losartan hauv cov ntshav txo qis,
erythromycin: tsis muaj ib qho tseem ceeb tshwm sim rau lub pharmacokinetics ntawm losartan thaum noj ntawm qhov ncauj,
ketoconazole: tsis muaj kev cuam tshuam ntawm cov metabolism ntawm losartan tom qab nws cov iv tswj kom txog rau thaum kev ua kom nquag plias metabolite,
fluconazole (inhibitor ntawm isoenzyme CYP2C9): qhov tseem ceeb ntawm cov nquag metabolite ntawm losartan poob qis, qhov chaw muag tshuaj tseem ceeb ntawm kev coj ua ke ntawm losartan thiab inhibitors ntawm isoenzyme CYP2C9 tsis tau kawm,
triamteren, spironolactone, amiloride thiab lwm yam tshuaj potassium-sparing diuretics, muaj cov tshuaj tua ntsev ntxiv los yog ntsev ntsev ntxiv: kev ua kom muaj ntsev ntau ntxiv yuav tsum sau tseg,
lithium npaj: kev txo qis ntawm cov roj ntsha lithium yog qhov ua tau, ua tib zoo saib xyuas ntawm theem ntawm lithium hauv cov ntshav yog tsim nyog,
non-steroidal anti-inflammatory tshuaj (NSAIDs), nrog rau xaiv cyclooxygenase-2 inhibitors (COX-2): nws muaj peev xwm ua kom tsis muaj zog tiv thaiv kev tiv thaiv ntawm losartan hauv cov neeg laus lossis cov neeg mob lub cev qhuav dej, nrog rau cov uas tau txais diuretics, nrog rau kev sib xyaw no, ib qho kev cuam tshuam uas tsis zoo hauv lub raum ua tau. , suav nrog qhov tshwm sim ntawm mob raum tsis zoo, kev sib txuam tshuaj yuav tsum muaj kev saib xyuas tshwj xeeb,
ob zaug thaiv ntawm RAAS (tib lub sijhawm siv ARA II thiab ACE inhibitors lossis renin inhibitor - aliskiren): qhov kev pheej hmoo ntawm cov hlab ntsha hypotension, hyperkalemia, syncope thiab lub raum tsis ua haujlwm (suav nrog mob raum tsis ua haujlwm) tau nce ntxiv thaum piv nrog kev kho mob hlwb, kev saib xyuas lub raum kev ua haujlwm, ntshav siab thiab concentration ntawm electrolytes hauv cov ntshav.

Muaj kev cuam tshuam tshwm sim ntawm kev sib cuam tshuam ntawm amlodipine nrog kev siv tib lub sijhawm nrog lwm cov tshuaj / cov neeg sawv cev:

digoxin, phenytoin, warfarin, indomethacin: tsis muaj ib qho kev cuam tshuam ntawm qhov khi ntawm cov tshuaj no rau cov ntshav plasma protein raws li kev tshawb pom hauv vitro,
cimetidine, antacids uas suav nrog magnesium lossis aluminium hydroxide, kua txiv kab ntxwv qaub (240 ml): tsis muaj ib qho kev cuam tshuam tseem ceeb ntawm cov tshuaj pharmacokinetics ntawm amlodipine thaum siv ib koob tshuaj tom kawg,
atorvastatin (ntawm ib koob li 80 mg): tsis muaj ib qho kev hloov pauv tseem ceeb ntawm qhov sib npaug ntawm cov tshuaj pharmacokinetic ntawm atorvastatin nrog cov rov qab ua ke ntawm amlodipine ntawm ib koob ntawm 10 mg,
sildenafil (ib koob tshuaj 100 mg): tiv thaiv keeb kwm ntawm kub siab, cov pharmacokinetics ntawm amlodipine tsis cuam tshuam, nrog kev sib txuam no, txhua yam ntawm cov tshuaj ntawm nws tus kheej qhia cov nyhuv antihypertensive,
tacrolimus: qhov kev pheej hmoo ntawm kev ua rau nws plasma concentration nce, qib ntawm cov khoom no hauv cov ntshav yuav tsum tau saib xyuas,
simvastatin (ntawm koob tshuaj 80 mg): thaum muab sib xyaw nrog amlodipine ntawm koob tshuaj 10 mg, kev cuam tshuam ntawm simvastatin nce li ntawm 77%, koob tshuaj txhua hnub ntawm simvastatin nrog kev sib xyaw no yuav tsum tsis txhob siab tshaj 20 mg,
dantrolene (iv kev tswj hwm): txoj kev pheej hmoo ntawm arrhythmia, tsaus muag, hyperkalemia thiab ib qho txo qis hauv lub plawv dhia nce;
cyclosporin: kev nce siab hauv nws qhov kev xav tau yog ua tau, hauv cov neeg mob tom qab hloov raum, nce Cmin ntawm cyclosporin hauv ntshav los txog li 40% tau sau tseg, thaum ua ke nrog Lozap AM, yuav tsum saib xyuas Cmin cyclosporin yog yuav tsum tau,
warfarin: tsis muaj nce hauv lub sijhawm prothrombin,
ethanol: tsis muaj qhov cuam tshuam tseem ceeb rau nws cov tshuaj pharmacokinetics,
itraconazole, ketoconazole, ritonavir (muaj zog inhibitors ntawm CYP3A4 isoenzyme): ntshav plasma concentration ntawm amlodipine yuav nce ntxiv, kev soj ntsuam cov tsos mob ntawm lub plawv hypotension thiab edema yuav tsum,
diltiazem (ntawm koob tshuaj ntawm 180 mg), erythromycin (tshuaj tiv thaiv ntawm CYP3A4 isoenzyme): thaum diltiazem ua ke nrog amlodipine ntawm koob tshuaj 5 mg, kev tsim tawm ntawm 1.6-npaug hauv AUC ntawm qhov kawg yog tshawb pom yog tias qhov sib xyaw no tau kho rau cov neeg laus uas muaj ntshav siab, thaum ua ke nrog erythromycin hauv kev noj qab haus huv. tsis muaj qhov cuam tshuam loj rau AUC ntawm amlodipine, txawm li cas los xij, hauv cov neeg laus, kev hloov pauv tseem ceeb hauv nws yuav raug kaw tseg,
clarithromycin (inhibitor ntawm CYP3A4 isoenzyme): qhov kev pheej hmoo ntawm kev txo qis hauv cov ntshav siab nce ntxiv, kev saib xyuas kev kho mob yuav tsum tau ua,
rifampicin perforated nrog St. John lub wort (inducers ntawm CYP3A4 isoenzyme): tsis muaj qhov cuam tshuam loj rau cov pharmacokinetic cov yam ntxwv ntawm amlodipine tau sau tseg; nws raug nquahu kom soj ntsuam ntshav siab.

Cov kev sib piv ntawm Lozap AM yog Lortenza, Amzaar, Amozartan, Lozartan, Sardip, thiab lwm yam.

Lub Npe Tsis Yog Neeg Tsis Muaj Npe

Losartan yog lub npe thoob ntiaj teb rau cov tshuaj.

C09DB Angiotensin II cov yeeb ncuab sib xyaw ua ke nrog BKK.

Lozap AM yog tshuaj rau txo ntshav siab thiab rov ua kom CCC.

Tso cov ntaub ntawv thiab cov nyob ua ke

Lozap yog ntsiav tshuaj nyob rau hauv lub plhaub yuav luag dawb. Muaj ob peb daim ntawv tso tawm, nyob ntawm qhov kev suav ntawm lub ntsiab feem - 12.5, 50, 100 mg.

cov khoom xyaw tseem ceeb yog losartan potassium,
microcrystalline cellulose, hmoov txhuv nplej siab, sodium stearate, dej, crospovidone, silicon dioxide.

Cov tshuaj yuav muag hauv cov thawv ntawv ntawm 3, 6 lossis 9 hlwv.

Kev txheeb xyuas ntawm Lozap AM

Kev txheeb xyuas txog Lozap AM yog feem ntau zoo. Cov neeg mob nco ntsoov qhov kev ua haujlwm zoo ntawm cov tshuaj thaum piv nrog Lozap, txij li Lozap AM muaj ob yam tshuaj uas nquag, nws yog kws kho rau kev siv nrog ntau dua AH lossis nrog kev txhim kho kev quav rau Lozap. Cov tshuaj, raws li kev txheeb xyuas, muaj cov txiaj ntsig zoo ntawm CVS thiab tso cai rau koj kom tswj ntshav siab txaus.

Qhia txog ntawm cov tshuaj

Lozap Am yog qhov sib xyaw ua ke uas muaj ob yam khoom xyaw, ib qho, cov ntsev amlodipine tshwj xeeb yog camsylate, uas muaj kev ruaj khov dua piv rau cov amlodipine besylate siv. Raws li kev soj ntsuam kuaj mob thiab kev soj ntsuam ntau ntawm Lozap Am 5 + 100 mg, nws tau pom tias, tsis zoo li lwm cov tshuaj tiv thaiv kabmob, cov tshuaj ua rau pom cov tshuaj tiv thaiv kab mob ntau dua, thaum cov kev mob tshwm sim thaum txoj kev kho yog qhov tsawg dua. Koj tuaj yeem yuav Lozap Am hauv ib lub tsev muag tshuaj thaum muab cov tshuaj los ntawm koj tus kws kho mob.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Cov tshuaj yog tsim los ntawm Czech lub tuam txhab Zentiva hauv daim ntawv ntsiav tshuaj: Lozap Am 5 ntxiv rau 100 mg lossis 5 + 50 mg, thawj tus lej qhia cov ntsiab lus ntawm amlodipine camsylate, thib ob - potassium losartan. Cov ntsiav tshuaj tau ntim rau hauv blisters 10 daim lossis ib lub raj mis yas ntawm 300 daim. Tus nqi ntawm Lozap Am yuav nyob ntawm qhov kev suav ntawm cov tshuaj yeeb dej caw thiab lub chaw muag tshuaj uas cov tshuaj yuav.

Kev ntsuas rau siv

Cov tshuaj yog tshuaj rau cov neeg laus thiab menyuam yaus txij li 6 xyoo nrog cov kab hauv qab no:

kub siab (ntshav siab),
kev tiv thaiv ntawm myocardial infarction,
arrhythmia, ischemia thiab lwm yam mob ntev ntawm CVS,
kub siab hauv cov neeg mob ntshav qab zib mellitus.

Cov tshuaj yog tawm rau cov ntshav siab.
Cov tshuaj yog tawm rau cov ntshav siab hauv cov neeg mob ntshav qab zib mellitus.
Cov tshuaj yog txhaj rau kev tiv thaiv ntawm myocardial infarction.

Nrog saib xyuas

Koj tuaj yeem noj cov tshuaj hauv cov koob tshuaj tsawg kawg nkaus nrog rau cov hauv qab no:

lub plawv tsis ua hauj lwm
hyperkalemia
dej-electrolyte tsis txaus,
arterial hypotension hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Koj tuaj yeem noj cov tshuaj hauv qhov tsawg kawg nkaus rau lub plawv tsis ua haujlwm.
Cov tshuaj yog contraindicated thaum lactation.
Koj tuaj yeem noj cov tshuaj hauv qhov tsawg kawg nkaus nrog arterial hypotension hauv cov menyuam yaus hnub nyoog qis dua 6 xyoo.

Li cas los noj Lozap AM

Cov ntsiav tshuaj tau noj ntawm qhov ncauj, tsis hais txog ntawm cov khoom noj. Cov qauv koob tshuaj yog 50 mg rau ib hnub. Nws yog kho raws tus neeg yam ntxwv ntawm tus neeg mob. Hauv cov kab mob plawv ntev, thawj koob yog 12,5 mg. Thaum tsis muaj cov kev mob tshwm sim, nws nce mus rau 50 mg kom tau txais qhov ua siab tshaj plaws.

Txog kev tiv thaiv ua mob plawv ntxiv, 50 mg noj ib hnub ib zaug. Kev kho mob kav ntev raws li kws kho mob kho plawv.

Noj cov tshuaj rau ntshav qab zib

Koj tsis tuaj yeem noj tag nrho cov tshuaj nyob rau thawj zaug. Nws yog ib qho tsim nyog yuav tau soj ntsuam cov tshuaj tiv thaiv ntawm lub cev, yog li nws pom zoo kom pib nrog 50 mg rau ib hnub. Nrog rau kev kho mob ntxiv, cov koob tshuaj nce rau 100 mg ib hnub. Koj tuaj yeem siv tam sim ntawd 100 mg lossis 50 mg hauv 2 pawg.

Ntawm ntshav qab zib mellitus, ib qho kev txhaj tshuaj tag nrho yuav tsum tsis txhob noj thawj zaug.

Hematopoietic plab hnyuv siab raum

Vim tias qhov khoom noj tsis zoo, muaj ntau dhau los lossis tsis muaj cov hlau, lithium, thiab cov vitamins. Vim tias qhov no, tus lej ntawm cov kabmob tshwm sim - ntshav liab, ntshav roj ntshav, thiab lwm yam.

Vim tias qhov khoom noj tsis zoo, muaj ntau dhau los lossis tsis muaj cov hlau, lithium, thiab cov vitamins.

Pawg twg ntawm cov tshuaj nws yog koom nrog?

Ua ntej koj yuav tsum xam seb pab pawg twg ntawm cov tshuaj Lozap belongs. Ntsiav tshuaj kom txo cov ntshav siab yog koom nrog pawg tshuaj antihypertensive.

Cov lus qhia rau kev siv hais tias lawv muaj kev cuam tshuam rau lub cev los ntawm kev tiv thaiv kev sib txuas ntawm angiotensin 2 nrog angiotensin receptors. Vim qhov no, cov ntshav tawm los li qub.

Cov tshuaj no zoo li cas los ntawm?

Cov cim qhia hauv cov lus qhia rau kev siv rau Lozap ntsiav tshuaj, los ntawm qhov lawv pab, muaj raws li hauv qab no:

pathologically siab siab,
mob plawv tsis ua hauj lwm - cov tshuaj tau suav nrog kev kho mob dav dav thiab nws txoj kev siv yuav tsum yog rau cov neeg mob uas tsis nkag rau ACE inhibitor pawg, nrog rau vim yog tsis muaj txiaj ntsig,
txo cov kev pheej hmoo ntawm kev ua kom pom lossis cuam tshuam ntawm lub siab thiab mob ntshav hauv cov neeg mob ntshav siab thiab sab laug ventricular hypertrophy,
nephropathy nyob rau hauv cov neeg mob ntshav qab zib thiab cov neeg mob ntshav siab.

Lwm tus xeeb ceem tseem ceeb ntawm cov tshuaj yog qhov muaj peev xwm nce lub cev tiv thaiv kev tawm dag zog lub cev. Tiv thaiv kev tiv thaiv lub plawv hypertrophy yog lwm qhov tseem ceeb ntawm Lozap ntsiav tshuaj. Cov lus qhia rau siv muaj cov ntaub ntawv koob tshuaj rau txhua lub pathology.

Yog tias koj ua raws li cov lus qhia rau kev siv hauv kev kho mob thiab paub tseeb tias yuav ua li cas noj tshuaj ntawm lub siab, ces cov txiaj ntsig ntawm kev txo qis siab tau tiav 5-6 teev tom qab kev tswj hwm, ces nws tseem tuav ib hnub. Nrog kev siv cov ntsiav tshuaj tsis tu ncua, ib qho txiaj ntsig tau tiav tom qab ib hlis tom qab siv Lozap ntsiav tshuaj.

Nrog cov cim zoo proteinuria, cov tshuaj pab ua kom muaj protein tsawg.

Los ntawm ib sab ntawm cov metabolism

Qhov tsis txaus ntawm cov metabolism hauv feem ntau tshwm sim thaum noj Lozap thiab lwm yam tshuaj uas cuam tshuam nrog losartan.

Kev tsis haum tshuaj muaj peev xwm ua tau nrog kev noj ntau dhau los yog ua rau ib tus neeg tsis haum rau cov khoom ntawm qhov muaj pes tsawg leeg. Qhia tawm pob khaus, khaus, liab ntawm daim tawv. Muaj qee zaus, txham lossis hnoos yuav tshwm sim.

Cawv tau zoo

Thaum siv tshuaj, nws yog nruj me ntsis txwv tsis pub haus dej cawv, vim hais tias losartan yog txhua yam sib xyaw nrog ethyl cawv.

Thaum siv cov tshuaj, nws yog txwv tsis pub haus cawv.

Siv thaum cev xeeb tub thiab lactation

Nws yog txwv tsis pub siv cov tshuaj hauv thawj thiab theem thib peb, vim tias muaj kev pheej hmoo ntawm kev txhim kho lub cev qis. Lub sijhawm HBV, nws tseem tsis raug nquahu kom siv cov tshuaj tiv thaiv kabmob, kom tsis txhob ua mob rau tus menyuam. Txoj kev tshawb no tau qhia tias losartan tuaj yeem ua rau tus me nyuam hauv plab khov.

Dab tsi lub siab kuv yuav tsum coj?

Kev ntsuas siab rau kev tsim kev kub siab rau txhua tus neeg yog tswj hwm los ntawm kws kho mob. Tsuas yog nws txiav txim siab txog lub sijhawm teem thiab tshem tawm. Nws yog nws tus kheej txwv tsis pub ua kev kho mob nrog Lozap. Cov lus qhia rau kev siv tsis tau hais thaum lub siab ntawm kev siv yog pom zoo, yog li kev kho yuav tsum tau tso rau tus kws tshaj lij.

Cov Hom Ntshav

Yuav noj li cas?

Lozap ntsiav tshuaj rau lub siab raws li cov lus qhia rau kev siv yog qhia tias haus dej haus ib hnub ib zaug, pib txoj kev kho nrog cov koob tshuaj qis dua. Ua ntej pib kev kho tshuaj, kev kho cov dej-electrolyte tshuav nyiaj yog ua. Raws li cov lus qhia rau kev txhim kho mob qog ntshav, tsuas yog siv tshuaj me me xwb.

Tsis tas li ntawd, cov ntsiab lus ntawm cov poov tshuaj tau nce hauv cov neeg laus, yog li rau lawv, raws li cov lus qhia, kev siv cov koob tshuaj tsawg kawg nkaus kuj tau tsim.

Cov tshuaj tsis cuam tshuam rau lub peev xwm tswj kev thauj mus los thiab kev saib xyuas zoo - cov yam ntxwv no tau qhia hauv cov lus qhia rau kev siv. Cov ntsiav tshuaj yuav tsum quag nrog lub ntim ntau ntawm cov kua kom tsis muaj kev phiv hauv kev ua haujlwm ntawm lub plab zom mov. Puas yog nws ua tau los haus Lozap thaum tsis tshua muaj siab - tsis yog, vim tias raws li cov lus qhia rau kev siv, nws yog npaj rau cov neeg mob ntshav siab txhawm rau txo cov ntshav siab.

Ua ntej lossis tom qab noj mov?

Thaum nug seb yuav noj Lozap ua ntej lossis tom qab noj mov, cov kws kho mob teb tias tsis muaj qhov sib txawv, vim tias raws li cov lus qhia rau kev siv, cov tshuaj yog noj ntawm qhov ncauj, tsis hais lub sijhawm noj mov.

Cov kws kho mob qhia meej tias thaum nug thaum siv Lozap, kev noj tshuaj ntau npaum li cas, muaj ntau kis yuav raug cais raws li cov lus qhia rau cov tshuaj:

Thaum kuaj pom tias mob ntshav dhau los, Lozap feem ntau yog kws kho, qhov ntau npaum li cas ib hnub yog 50 mg raws li cov lus qhia. Qee zaum, txhawm rau kom muaj txiaj ntsig ntau dua, qhov koob tshuaj yog ob npaug, tab sis nws tseem coj 1 zaug.
Rau cov neeg muaj lub plawv tsis ua haujlwm ntev, lub koob tshuaj yog 12,5 mg ib hnub ib zaug. Nws nce txhua txhua lub lis piam mus rau qhov nruab nrab ntawm 50 mg. Kev zam ntawm kev siv tshuaj thiab cov tshuaj tiv thaiv kev tiv thaiv raws li cov lus qhia yuav tsum tau coj mus rau hauv tus account.
Rau cov neeg mob niaj hnub kho nrog kev siv tshuaj ntau dhau, kev pib ua kom tsawg zog mus rau 25 mg ib hnub twg.
Hauv cov neeg laus, thaum pib tus kws kho mob tsis kho cov koob tshuaj 50 mg ib hnub twg.
Thaum siv cov tshuaj yog qhia rau txo cov kev pheej hmoo ntawm kev ua kom pom kev mob plawv thiab tiv thaiv kev tuag nyob rau hauv cov neeg muaj ntshav siab, raws li cov lus qhia, thawj koob tshuaj yog 50 mg rau ib hnub. Sij hawm dhau mus, nws nce mus txog 100 mg.
Rau cov neeg mob ntshav qab zib mellitus thiab proteinuria, kev muab tshuaj thawj zaug yog 50 mg rau ib hnub, maj mam nce mus txog 100 mg. Tab sis kws kho mob yuav tsum xav txog cov ntsuas ntshav siab.
Hauv kev muaj kab mob hauv daim siab ua kom lub siab lossis thaum lub cev qhuav dej tom qab hemodialysis ntawm lub tshuab tso, tom qab 75 xyoo, koj yuav tsum xub txo cov tshuaj rau 25 mg ib hnub twg.

Tag nrho cov tshuaj thiab cov tshuaj ntawm cov tshuaj tuaj yeem pom nyob rau hauv cov lus qhia rau kev siv.

Lub sijhawm ntev npaum li cas nws tuaj yeem tau txais?

Thaum muab tshuaj rau, cov neeg mob nug tam sim ntawd yuav ntev npaum li cas Lozap tuaj yeem noj tau. Tom qab xaiv cov koob tshuaj uas tsim nyog, nws txoj kev siv tau ntev rau ntau lub hlis thiab txawm ntau xyoo. Txhua yam nws yog nyob ntawm nws cov hauj lwm zoo.

Yog tias tsis muaj cov kev mob tshwm sim, lub siab ruaj khov rau qhov zoo, ces koj yuav tsum tsis txhob hloov lub cuab yeej. Kev so hauv kev kho tsuas yog ua tau raws li kev pom zoo los ntawm tus kws kho mob. Thaum cov tshuaj raug muab tso tseg, txoj kev mob siab tuaj yeem tshwm sim. Lub caij nyoog ntawm kev noj Lozap raws sijhawm yog txiav txim los ntawm tus kws kho mob.

Txuj Ci

Cov qauv kev mob tshwm sim tau piav qhia nyob rau hauv cov lus qhia rau kev siv thiab nrawm nrawm nrog kev tswj hwm txuas ntxiv:

mob plab
mob hauv siab hauv siab,
nkees sai
me ntsis o ntawm ob txhais ceg thiab caj npab,
zawv plab
lub plawv dhia
xeev siab
mob taub hau
cramps hauv plab hlaub nqaij
kev ntxhov siab vim pw tsaug zog
hnoos
ntswg ntswg.

Nrog siv ntev

Cov kev mob tshwm sim ntawm Lozap nrog kev siv ntev ntev tuaj yeem cuam tshuam cov kabmob sib txawv thiab cov tshuab, vim tias qhov kev txuam nrog tshuaj nyob rau hauv lub cev maj mam tshwm sim. Lawv tsim cov kev txhaum nram qab no:

plaub hau ploj mus rau qhov do hau vim yog nce ntawm daim tawv nqaij rhiab thiab tshem tawm hws nquag,
ua xua nyob rau hauv cov cheeb tsam nrog cov tawv nqaij sib chwv,
ib tug malfunction nyob rau hauv kev ua hauj lwm ntawm cov hlab plawv system - lub plawv mob, los ntswg,
ua txhaum ntawm lub luag haujlwm ntawm lub plab zom mov: plab zom mov, cem quav thiab zawv plab, tsis hnov qab,
tsis zoo nyob rau hauv qhov kev nkag siab ntawm tsis hnov tsw thiab saj buds,
heev xeev ntawm kev ntxhov siab
nquag tso zis.

Kev sib raug zoo thiab siv nrog uake

Hauv lub sijhawm ntawm cov tshuaj, tus neeg mob yuav tsum soj ntsuam seb nws haus cov tshuaj dab tsi ntxiv, muab lawv sib xyaw, nws zoo dua ntxiv rau qhov kev kuaj xyuas cov lus qhia rau siv. Tsis tas li, muaj kev tsis sib haum xeeb yog los ntawm kev haus dej haus cawv thaum lub sijhawm siv cov tshuaj no.

Puas yog nws ua tau kom Lozap nrog cawv cawv - tib neeg nyiam. Qee tus neeg mob ntseeg hais tias cawv yuav tsis ua mob rau lub sijhawm kho thiab qhov ib txwm sib xyaw ntawm Lozap thiab cawv.

Kev tshuaj xyuas ntawm cov neeg uas tau ntsib zoo li no cuam tshuam rau lawv tus kheej hais qhia qhov tsis sib xws. Tom qab tag nrho, cov nyhuv ntawm cov tshuaj kav rau ib hnub los ntawm lub sijhawm ntawm kev tswj hwm, thiab rau cov txiaj ntsig ntawm kev nqis tes ua nws tau ua nyob rau hauv ntev kev kawm. Hauv qhov no, Lozap thiab cawv yog qhov tsis sib xws kiag li.

Bisoprolol

Bisoprolol thiab Lozap - raug tso cai los ntawm kev siv yeeb tshuaj. Cov tshuaj no yog los ntawm cov pab pawg sib txawv txawv. Raws li cov lus qhia rau kev siv, Bisoprolol yog adrenergic blocker, uas feem ntau tswj lub plawv dhia, txo nws.

Lozap - txo cov ntshav siab. Ua ke, cov tshuaj no ua tau zoo hauv kev nce siab pathological nrog tachycardia, arrhythmia, thiab mob plawv ntev.

Qhov no yog cov tshuaj yeeb tshuaj uas paub zoo siv raws li cov lus qhia rau kev kho mob ntshav siab, nrog kev tsim cov edema hnyav vim lub plawv tsis ua lossis lwm yam. Qhov no yog lub diuretic uas, thaum tawg tawm, ua haujlwm ua vasodilator. Cov lus nug tshwm sim: nws yog qhov ua tau kom coj Lozap thiab Indapamide ua ke.

Kapoten thiab Lozap - lawv kev sib raug zoo yog qhov muaj kev sib cav heev, txawm hais tias nws tsis tuaj yeem hais tias lawv tsis sib xws.

Qee qhov xwm txheej, tshuaj mob angiotensin receptor blocker tuaj yeem ua ke nrog cov tshuaj angiotensin hloov kho enzyme inhibitory tshuaj, uas tso cai rau ua kom tau zoo dua hypotensive. Txawm li cas los xij, hauv kev coj ua, cov kws kho mob tsis tshua muab tshuaj nrog kev sib luag nrog cov tshuaj no.

Tus Tswv Eprosartan

Eprosartan tuaj yeem raug coj ib zaug lossis hloov tawm ntawm chav kawm. Nrog rau ib qho siv, lub siab ruaj khov thiab nws ib txwm nyob txhua hnub. Lub zog kho kom ruaj khov tuaj yeem ua tiav tsuas yog tom qab ob peb lub lim piam ntawm kev siv tas li.

Eprosartan thiab Lozap muaj cov nyhuv zoo sib xws, tab sis sib txawv. Hauv qhov no, lo lus nug tshwm sim seb nws puas ua tau tib lub sijhawm Eprosartan nrog Lozap. Koj tsis tas yuav ua qhov no, thiaj li tsis ua rau muaj ob qho txiaj ntsig thiab tsis ua rau muaj kev phiv, uas, raws li cov lus qhia rau kev siv, cov nyiaj no yuav luag zoo li qub.

Lus pov thawj ntawm cov neeg uas noj cov tshuaj no

Koj tuaj yeem tshawb pom qhov ntau ntawm kev soj ntsuam zoo ntawm tib neeg hais txog cov tshuaj. Nws ua hauj lwm zoo txo kev ntxhov siab, ua kom lub siab ua haujlwm thiab pw tsaug zog, tshem tawm kiv taub hau. Cov neeg mob hais tias Lozap ua haujlwm nrawm, tab sis ib qho txiaj ntsig ntev yog tsis pom. Cov lus qhia tau hais tias qhov tshwm sim yuav kav ib hnub, tab sis qee zaum nws kav ntev li 4 teev. Tab sis yog tias koj txo qhov koob tshuaj thiab siv sijhawm tsis yog 1 zaug, tab sis ntau zaus, ces cov txiaj ntsig tsuas tau txaus rau 24 teev. Cov neeg mob nco ntsoov tias kev siv koob tshuaj qis dua ua rau txo qis kev phom sij. Tab sis nrog txoj hauv kev no, qhov tshwm sim tom qab noj cov ntsiav tshuaj yuav tsis tuaj tsis dhau 30 feeb, tab sis hauv 1.5 teev.

Tsis tas li, cov neeg mob nco ntsoov tias haus Lozap nws tsis yooj yim vim yog qhov muaj zog diuretic nyhuv, los ntawm nws muaj nquag tso zis tso zis. Qhov no tau tshwj xeeb tshaj yog sau los ntawm cov neeg ua haujlwm. Cov kev txheeb xyuas kuj piav qhia txog cov neeg muaj mob ua pa hnoos thaum hmo ntuj tom qab pib noj, uas yog qhov nyuaj rau tshem tawm txawm tias tom qab tshem tawm tau.

Cov tshuaj muaj ntau cov yeeb yaj kiab los yog cov tshuaj zoo sib xws nrog cov nyhuv zoo ib yam, cov no yog cov tshuaj pheej yig ntawm Lozap. Tab sis lawv cov lus qhia muaj lawv qhov sib txawv, thiab tsuas yog tus kws kho mob tuaj yeem txiav txim siab yuav ua li cas los hloov Lozap.

Thaum muab piv Lozartan thiab Lozap, dab tsi zoo dua yog cov lus nquag nug.Raws li cov lus qhia rau kev siv, ob qho tshuaj yog qhia rau kev kho mob tawg. Lawv yog cov angiotensin receptor antagonists.

Lozap thiab Losartan yog ib qho thiab tib yam, txij li lub tshuaj nquag ntawm ob txhais tau tias tib si. Ob qho tshuaj muaj txiaj ntsig sib luag hauv cov ntshav siab, tab sis qhov no tsis yog lub laj thawj rau txoj kev xav tsis hloov pauv ntawm kev txais tos ntawm ib qho nrog lwm tus. Tsuas yog tus kws kho mob yuav tsum muab cov lus qhia tsim nyog.

Yog tias peb tham txog cov tshuaj ntawm Lozap lossis Lorista, uas ntawm lawv zoo dua, tsis muaj qhov sib txawv. Lawv txawv hauv cov tuam ntxhab thiab nqi nkaus xwb. Lozap yog qhov pheej yig dua, cov so yog zoo li cov lus qhia rau kev siv.

Ua ntej txiav txim siab Valsartan lossis Lozap, uas yog qhov zoo dua, koj yuav tsum nkag siab txog lawv qhov zoo. Qhov kom zoo dua ntawm Valsartan yog nws daim ntawv teev tshuaj, feem ntau nws yog dhau los ntawm txoj hnyuv tsis hloov - 83%, thiab 13% los ntawm lub raum. Hauv kev hais txog qhov no, nws yog feem ntau kho rau cov kab mob ntawm daim siab thiab lub raum, vim nws tsis ntxiv ntxiv cov ntsaws cov kabmob no.

Raws li cov lus qhia rau kev siv, cov tshuaj yog xav kom txhaws hauv cov hlab ntsha thiab cov hlab ntsha. Yog li nws normalizes thiab tswj lub siab. Txhawm rau xaiv Valsacor lossis Lozap - uas yog qhov zoo dua, koj yuav tsum paub qhov sib txawv ntawm cov nyiaj no: Valsacor yog cov lus qhia ncaj qha ntawm Valsartan, uas txhais tau tias nws ua rau tib lub ntsiab cai, tsis cuam tshuam rau lub siab thiab yuav luag tsis cuam tshuam rau lub raum. Tsis tas li, nws cov nyhuv hypotensive yog ob peb chav haujlwm ntau dua.

Vim tias tus nqi ntau dua ntawm cov khoom no, cov neeg mob xav tau dab tsi zoo dua li Valz lossis Lozap. Yog li, Valz yog ib qho tshuaj tiv thaiv hypotensive, thaiv ntawm AT1 receptors ntawm angiotensin II. Raws li cov lus qhia, nws tsis muaj contraindications los cuam tshuam nrog lwm cov tshuaj, nws cov nyhuv hypotensive tau kawm hauv kev nthuav dav ntxiv, noj cov tshuaj muaj cov txiaj ntsig zoo hauv kev kwv yees ntawm tus kab mob.

Tshuaj tiv thaiv kab mob siab, ACE inhibitor. Thaum teb cov lus nug, uas yog ib qho zoo dua, Lozap lossis Enalapril, koj yuav tsum qhia meej tias cov tshuaj thib ob txo cov tshuaj siab sai dua thiab ntau dua. Tus nqi ntawm Enalapril, ntawm qhov tsis sib xws, tuaj yeem pheej yig dua. Tab sis nws yuav tsum tau yug hauv siab tias, zoo li txhua tus ACE inhibitors, nws feem ntau ua rau ib sab hnoos.

Qhov no yog ib qho tshuaj tiv thaiv kabmob uas, raws li cov lus qhia, txo cov ntshav siab tsis muaj ntshav nce siab hauv lub plawv. Txawm hais tias tus nqi pheej yig ntawm Enap, cov kws kho mob, thaum teb cov lus nug ntawm qhov uas zoo dua, Enap lossis Lozap, pom zoo thawj qhov rau kev nkag.

Lisinopril

Cov tshuaj no yog los ntawm cov pab pawg ntawm ACE inhibitors. Qhov twg zoo dua, Lozap lossis Lisinopril, yog ib lo lus nug nquag nug hauv cov neeg mob. Ob leeg tshuaj nrog kub siab ua zoo sib xws, tab sis raws li cov lus qhia, hnoos dhau los ua kev cuam tshuam ntawm Lisinopril. Tus nqi yog ib yam.

Qhov no yog cov yeeb tshuaj muaj zog, ACE inhibitor, raws li cov lus qhia, lub sijhawm ntev ntawm cov nyhuv tseem mob rau ib hnub. Lub hauv paus tseem ceeb ntawm Diroton yog lisinopril, thiab cov nyhuv ntawm ob yam tshuaj yog tib yam. Vim li ntawd, txhawm rau kom nkag siab Diroton lossis Lozap, uas yog qhov zoo dua, koj yuav tsum paub tias cov kws kho mob hloov Diroton Lozap tsuas yog nrog lisinopril tsis tau txais txiaj ntsig.

Pheej Yig

Txhawm rau kom nkag siab qhov twg zoo dua - Lozap lossis Prestarium, koj yuav tsum to taub lawv qhov sib txawv. Prestarium yog ACE inhibitor, raws li cov lus qhia nws tau siv rau cov qauv mob ntshav siab, rau kev cuam tshuam loj heev ntawm cov hlab ntsha thiab lub siab, vim nws txo qis siab ntseeg nkaws. Nws tus nqi qis dua. Tab sis Lozap tsis muaj cov kev mob tshwm sim ntawm cov pab pawg ACE inhibitor - hnoos qhuav.

Noliprel yog cov tshuaj sib xyaw. Nyob rau hauv nws cov muaj pes tsawg leeg tam sim ntawd 2 cov khoom siv sib xyaw ntawm perindopril thiab indapamide, uas cuam tshuam rau lub cev tib lub sijhawm, yog li nws ua tau ntau dua.

Qhov kev mob pheej tshwm sim tau pom tom qab ib hlis ntawm kev siv thiab tsis nrog los ntawm kev nce siab hauv lub plawv. Hauv qhov no, lo lus teb rau lo lus nug ntawm qhov twg zoo dua - Lozap lossis Noliprel pom tseeb.

Yuav kom hais qhov tseeb Concor lossis Lozap uas yog qhov zoo tshaj plaws ntawm lawv yuav swb. Lawv feem ntau tau hais kom haus ib txhij nyob hauv cov chaw nyob. Concor yog beta-blocker uas tsis tsuas yog txo qis ntshav siab, tab sis kuj normalizes lub plawv dhia. Raws li cov lus qhia, Lozap tau noj thaum sawv ntxov, thiab Concor - thaum yav tsaus ntuj. Kev sib xyaw tshwj xeeb yog xaiv los ntawm tus kws kho mob raws li kev mob thiab tus yam ntxwv ntawm tus neeg mob lub cev.

Txoj kab zauv yog cov tshuaj sib xyaw ua ke nrog. Txhawm rau teb cov lus nug Equator lossis Lozap - uas yog qhov zoo dua, cov hauv qab no yuav tsum tau sau tseg: hauv kev sib piv nrog Equator, Lozap muaj tsawg dua qhov kev tiv thaiv tsis zoo raws li cov lus qhia rau kev siv.

Cov tshuaj Lozap AM yog tus cwj pwm los ntawm lub zog muaj zog dua, vim nws muaj 2 yam haujlwm: losartan poov tshuaj thiab amlodipine. Qhov no yog cov cuab yeej siv tau zoo dua qub thiab nws txoj kev siv raws li cov lus qhia yog qhia hauv cov xwm txheej nyuaj thaum Lozap tsis pab lossis tau dhau los ua tus yees hauv lub cev.

Cov lus thiab cov xwm txheej ntawm kev cia

Thaum khaws cia Lozap Am, nws yog qhov tsim nyog yuav tau soj ntsuam chav kub tsis tshaj 30 degrees Celsius. Lub txee lub neej ntawm cov tshuaj yog nees nkaum plaub lub hlis, tom qab lub sijhawm no cov tshuaj yog txwv tsis pub siv thiab yuav tsum muab pov tseg. Koj tuaj yeem xaj kom xa khoom ntawm Lozap Am hauv Moscow thiab thaj chaw ntawm peb lub vev xaib.

Siv rau lub raum tsis zoo muaj nuj nqi

Raws li cov kev tshawb fawb pharmacokinetic, nws hloov tawm tias qhov tshwm sim ntawm kev noj Lozap, lub raum tsis ua haujlwm tuaj yeem tsim kho, yog li ntawd, cov neeg muaj kev tsis zoo lub raum yuav tsum tau siv qhov tsawg kawg nkaus ib zaug ib hnub. Yog tias tsis pom, nws muaj peev xwm ua kom tag nrho lub cev, uas yuav ua rau lub raum hloov pauv.

Contraindicated kev sib txuas ua ke

Nws yog txwv tsis pub siv Lozap nyob rau hauv kev sib xyaw nrog cov tshuaj diuretics, uas pab txhawb kom muaj cov poov tshuaj ntau ntxiv, piv txwv li nrog Amiloride, Spironolactone, vim tias hyperkalemia tuaj yeem tshwm sim.

Nws yog txwv tsis pub siv Lozap nyob rau hauv kev sib xyaw nrog diuretics, uas ua rau kom muaj kev txuam nrog cov poov tshuaj.

Tej kev sib txuam uas xav tau ceev faj

Nrog rau kev siv cov tshuaj uas tsis yog tshuaj steroidal ua ke nrog cov pab pawg, cov nyhuv ntawm lazartan yuav txo qis, yog li kev tshem tawm ntawm kev kub siab yuav dhau los ua lub ntsiab lus, zoo li nrog cov tshuaj placebo pawg (tsis yog tshuaj).

Yog tias, rau qee qhov laj thawj, Lozap tsis tuaj yeem nqa, nws tuaj yeem hloov nrog cov tshuaj ntawm cov nyhuv zoo:

raws li hydrochlorothiazitis - Angizar, Amlodipin, Amzaar, Gizaar, Lorista, Lozap ntxiv (cov tshuaj Lavxias),
raws li candersartan - Kandekor, Kasark, Hizart-N,
Cov tshuaj tivthaiv tseem ceeb ntawm telmisartan yog Mikardisplyus, Telpres, Talmista.

Ua ntej siv ib qho analog, koj yuav tsum tau sab laj rau cov kws tshaj lij. Rau cov neeg mob laus uas ua tsis tau, Lozap yog hloov nrog Amlodipine.

Amlodipine yog ib qho ntawm cov yeeb yaj kiab ntawm cov tshuaj Lozap AM.
Kasark yog ib qho ntawm cov yeeb yaj kiab ntawm cov tshuaj Lozap AM.
Mikardisplyus - ib qho ntawm cov yeeb yaj kiab ntawm cov tshuaj Lozap AM.

Kev kho plawv

Svetlana Aleksandrovna, Phlebologist, Rostov-on-Don

Kuv qhia ntau tus neeg mob kom noj Lozap, vim tias nws cuam tshuam rau CVS thiab txo qis ntshav siab, tiv thaiv ntau yam kab mob. Raws li cov ntaub ntawv soj ntsuam, qhov no yog ib qho tshuaj zoo tshaj plaws rau kev kub siab.

Sergey Dmitrievich, kws kho plawv, Irkutsk

Kuv sau ntawv rau ntau tus neeg mob tom qab phais mob kom tswj hwm qhov ib txwm muaj, kom tshem tawm kev tawm tsam kev kub siab.

Lozap AMC cov kws kho plawv cov lus ntuas

Olga Vasilievna, 56 xyoo, Kurganinsk

Kuv tau noj Lozap ntau dua 5 xyoos. Kuv muaj theem 2 ntshav qab zib. Cov tshuaj yog qhov txaus siab kiag li, lub siab yog qhov ib txwm ua, tsis muaj kev phiv.

Ivan, 72 xyoo, Moscow

Kws kho tus kws kho mob muab tshuaj rau kev tiv thaiv plawv, vim kuv muaj mob rau cov hlab ntshav cov leeg. Thaum nws pab, Kuv xav tias 30 xyoo yau dua.

Pheej pheej yig analogues

Cov kws kho mob feem ntau hais txog qhov tshuaj Lozap. Analogs thiab hloov chaw rau cov tshuaj yeeb tshuaj yog siv rau ntawm qhov muaj yees rau lub cev.

Vazotens yog hloov pauv rau Lozap ntsiav tshuaj. Nws muaj tib lub qub txav tivthaiv, nrog rau cov npe sib xws. Kev siv cov tshuaj yog contraindicated rau cov poj niam cev xeeb tub thiab thaum lactation, nrog rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Blocktran yog ib qho kev hloov pauv rau Lozap ua nyob rau hauv Russia. Nws muaj tib cov tshuaj nquag, yog li nws txoj kev siv feem ntau sau tseg hloov Lozap rau kev kho mob plawv thiab ntshav siab.
Lozarel yog ib qho duab ntawm Lozap. Cov tshuaj ua kom nquag muaj zog zoo ib yam thiab nyob hauv tib lub tshuaj. Yog li, cov lus qhia rau kev siv tshuaj kuj ua ke nrog cov npe ntawm kev cim thiab cov mob tshwm sim.

Dab tsi los hloov yog tias Lozap tsis tuav lub siab?

Yuav ua li cas los hloov Lozap, yog tias nws tsis tuav lub siab, yog cov lus nug heev thaum kev hais daws yuav tsum tsis ua haujlwm. Cov kws tshaj lij hloov nws nrog lwm cov tshuaj nrog tib ntsuas raws li cov lus qhia rau kev siv.

Qhov no feem ntau tshwm sim vim qhov tseeb tias kub siab yog tas li kev nce qib thiab cov tshuaj thaum kawg ua qhov tsis zoo. Muaj peb lub tswv yim los daws cov teeb meem no:

koob tshuaj nce
kev teem sijhawm ntawm kev sib xyaw ua ke, uas yog, kev noj tshuaj ntxiv,
hloov cov khoom siv tau.

Cov npe ntawm lawv yog muab rau saum toj no. Ua raws li tus neeg mob cov kab mob hauv tus neeg mob thiab cov lus qhia rau cov tshuaj, tus kws kho mob xaiv cov kev cai ntawm kev kho mob thiab ua tib zoo saib xyuas nws cov txiaj ntsig hauv qee qhov xwm txheej.