Tshuaj Ntsiav Tshuaj Leskol Forte

Ib qho ntawm cov tshuaj muaj zog tshaj plaws hypocholesterolemic niaj hnub no yog Leskol Forte, cov lus qhia uas qhia tau tias qhov cuab yeej no yog tsom rau kev ua kom cov ntshav txhaws thiab tshem tawm cov lipids.

Kab mob hauv lub plawv, uas ua rau cov cholesterol nyob hauv ntshav nce siab, nyob hauv ib qho chaw siab tshaj plaws hauv kev qeb duas kev txaus ntshai. Txog 20% ntawm cov neeg tuag txhua xyoo sau los ntawm cov txheeb cais thoob ntiaj teb yog:

mob plawv thiab nws cov teeb meem,
plawv nres.

Hauv cov pab pawg muaj kev pheej hmoo rau kev txhim kho mob no, ua ntej txhua yam, cov neeg muaj teeb meem ntawm lub vascular system yuav tsum nqa tuaj. Thiab ntawm no, cov roj (cholesterol) phem tau ua lub luag haujlwm tseem ceeb.

Vim li no ntau tus kws tshaj lij pom zoo tias lawv cov neeg mob yauv ua kom tsis huv thiab ntxuav tawm ntawm lub cev ntawm cov lipids tsis zoo. Cov plahaum roj ntau ntau hauv cov hlab, thiab ib zaug lawv tuaj yeem txhaws tau lub lumen thiab dhau los ua ib qho kev khuam siab rau ntxiv ntshav txav. Qhov no yog qhov xwm txheej tuag taus uas yuav tsum tsis txhob tso cai rau qee kis.

Kev taw qhia thiab tsuas tshuaj

Cov tshuaj los ntawm lub chaw tsim tshuaj Novartis tsis tuaj yeem noj yam tsis muaj kev pom zoo los ntawm kws kho mob. Leskol Forte, uas muaj cov tshuaj fluvastatin sodium, yog suav tias yog cov tshuaj muaj zog rau cov roj cholesterol, yog li nws yuav tsum tsis txhob siv los kho cov menyuam yaus hnub nyoog qis dua 9 xyoos.

Cov neeg mob uas muaj hnub nyoog tshaj 18 xyoo, Leskol Forte, uas nws cov duab tuaj yeem pom me ntsis siab dua, yog tau sau tseg rau cov tshuaj hypercholesterolemia sib xyaw nrog dyslipidemia. Hauv qhov no, cov tshuaj yuav tsum tau nrog los ntawm kev xaiv noj kom zoo. Rau cov teeb meem uas muaj cov roj cholesterol siab, nws raug nquahu kom koj xub xyuas koj cov khoom noj kom yuag. Qhov no twb yog ib nrab ntawm txoj kev kom muaj yeej.

Rau cov neeg mob laus, cov tshuaj no tau raug sau ua kab mob rau cov hlab ntshav siab, yog tias tus neeg mob kuaj pom tus mob coronary artery disease. Leskol Forte ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv ntawm ntau yam kabmob uas cuam tshuam nrog cov kab mob plawv. Piv txwv li, cov kws tshwj xeeb tuaj yeem pom zoo cov tshuaj no rau cov neeg uas muaj kev pheej hmoo tom qab phais mob plawv, nrog myocardial infarction thiab qhov muaj feem ntau ntawm kev tuag sai los ntawm kev ntes plawv.

Leskol kuj tseem siv tau los kho cov menyuam yaus thiab tub ntxhais hluas. Nws yog siv los kho kab mob heterozygous tsev neeg hypercholesterolemia. Hauv qhov no, nws yog ib qho tseem ceeb uas yuav tsum tau muab cov tshuaj kom zoo nrog ib qho khoom noj uas tsim nyog.

Qhov ua tau zoo tshaj plaws ntawm cov tshuaj tau tiav los ntawm 4 lub lim tiam ntawm nws txoj kev siv. Yog li, cov chav kawm ntawm kev coj Leskol Forte yuav nyob ntev. Raws li rau qhov ntau npaum, nws ib txwm xaiv ib tus zuj zus, nyob ntawm ntau yam ntsig txog. Koj tuaj yeem noj tshuaj thaum lub sijhawm nruab hnub. Nws yog qhov tsim nyog los haus ib lub tshuaj ntsiav nrog dej kom ntau. Yog tias cov tshuaj siv rau lub hom phiaj prophylactic, ntau npaum li cas thiab cov zaus ntawm kev tswj hwm yuav raug txo kom tsawg.

Tom qab siv sijhawm ntev ntawm Leskol, nws cov hauj lwm tseem nyob rau ib lub sijhawm ntev. Qee qhov xwm txheej, txawm tias nws los txog rau menyuam yaus, kev kho mob Leskol Forte tuaj yeem ncua ntev txog 6 lub hlis. Cov tshuaj no zoo meej rau kev kho mob monotherapy. Tab sis nws tuaj yeem ua ke nrog lwm cov tshuaj.

Kev ntsuas rau siv

Thawj hypercholesterolemia (heterozygous tsev neeg thiab tsis-tsev neeg, hom IIa, IIb hom thiab sib xyaw raws li Frederickson kev faib tawm) - nrog kev kho mob tsis muaj txiaj ntsig hauv cov neeg mob uas muaj kev pheej hmoo ntawm txoj kev mob ntshav siab, ua ke nrog hypercholesterolemia thiab hypertriglyceridemia, tsis lees paub tshwj xeeb lub cev atherosclerosis tiv thaiv lub cev tom qab thiab lub cev. Ischemic mob plawv.

Cov kev thaiv tsis zoo thiab cov tshwm sim

Cov tshuaj no, thaum siv kom raug, raug siab zoo los ntawm cov neeg mob. Txawm li cas los xij, ua ntej pib kev kho mob, nws yog qhov yuav tsum tau sab laj nrog kws kho mob, vim tias Leskol Forte muaj ntau qhov kev siv tshuaj tiv thaiv hnyav.

Ua ntej ntawm tag nrho cov, koj yuav tsum xav txog tias lub active cheebtsam ntawm cov tshuaj yog excreted tsuas yog los ntawm daim siab. Tsawg dua 6% ntawm tag nrho cov tshuaj noj nrog cov ntsiav tshuaj yog ua los ntawm ob lub raum. Yog li ntawd, ib qho kev tsis txaus ntseeg kiag rau kev siv Leskol tsiav tshuaj yog daim siab pathology hauv theem nquag.

Tsis tas li ntawd, cov kws txawj tsis pom zoo kom siv cov tshuaj no thaum cev xeeb tub thiab lactation. Rau cov neeg uas muaj lub siab ntsws qhov tsis zoo rau Cheebtsam ntawm Leskol Forte, cov tshuaj tiv thaiv kab mob sib piv ua rau koj hloov nws nrog lwm cov tshuaj uas muaj cov nyhuv zoo sib xws.

Raws li kev txwv hnub nyoog, nws tsim nyog teev cov me nyuam muaj hnub nyoog txog 9 xyoos. Cov kev tshawb fawb pom tau tias cov neeg laus zam cov tshuaj kom zoo, yog li rau cov neeg mob hnub nyoog 65 xyoos rov saud, kev kho qhov tsis haum thiab ntau npaum li cas los tsis tsim nyog.

Cov lus qhia tau qhia tias feem ntau cov neeg mob zam rau Leskol Forte zoo. Txawm li cas los xij, hauv qee kis, qee qhov kev mob tshwm sim thaum kuaj tshuaj:

mob taub hau
insomnia
mob plab
kev xav ntawm xeev siab
ua pob rau ntawm lub cev.

Los ntawm cov hlab plawv system, cov cim qhia ntawm vasculitis tsis cais. Cov kev mob tshwm sim yog ua tau tsuas yog siv cov tshuaj tsis raug cai thiab dhau qhov ntau npaum li cov kws kho mob tau pom zoo.

Leskol Forte thiab lwm yam tshuaj

Muab hais tias lub ntsiab lus tseem ceeb ntawm cov tshuaj no yog fluvastatin, uas qhov kev sib txuas lus tsis cuam tshuam nrog lwm yam tshuaj, cov tshuaj tuaj yeem ua ke nrog txhua cov tshuaj. Txawm li cas los xij, thaum siv qee ntawm lawv, koj tseem yuav tsum xav txog qee yam.

Piv txwv li, yog tias Leskol raug noj ib txhij nrog Rimfapicin, tom qab ntawd qhov no tuaj yeem txo qis cov nyhuv ntawm thawj. Qee lub sij hawm muaj kev txo qis hauv kev nyab xeeb txog li 50%. Thaum muaj qhov xwm txheej zoo li no, tus kws kho mob tuaj yeem kho cov tshuaj lossis ntau npaum li cas.

Cov tshuaj yeeb yaj kiab tau siv los kho lub plab zom mov, xws li Ranitidine thiab Omeprazole, tuaj yeem, ntxiv rau kom qhov nqus ntawm fluvastatin. Yog li ntawd, cov hauj lwm zoo ntawm cov tshuaj yuav nce ntxiv.

Thaum kis ntawm contraindications rau kev siv ntawm Leskol Forte, nws tuaj yeem hloov los ntawm analogues. Qhov no tuaj yeem yog Atoris, Torvakard, Rosart, Vasilip, Astin, Livazo, lossis lwm yam ntawm ntau kaum ob ntawm cov nyiaj nrog kev ua haujlwm zoo sib xws.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, thaum yav tsaus ntuj lossis thaum yuav mus pw, tsis hais tus noj mov. Capsules / ntsiav tshuaj yuav tsum nqos tag nrho nrog ib khob ntawm dej. Ua ntej pib kev kho mob, tus neeg mob yuav tsum pauv mus rau ib qho kev noj haus hypocholesterol, uas yuav tsum raug pom thaum kho.

Thawj koob tshuaj yog 20-40 mg lossis 80 mg ib hnub ib zaug (koob tshuaj 40 thiab 80 mg tuaj yeem siv 2 thiab 3 koob tshuaj, sib ntxiv). Hauv qee tus mob me me ntawm tus kab mob, ib koob tshuaj 20 mg / hnub yuav txaus.

Thawj koob tshuaj yuav tsum tau xaiv ib tus zuj zus, suav txog qhov pib ntawm cov roj (cholesterol) / LDL thiab lub hom phiaj ntawm txoj kev kho.

Cov koob tshuaj hloov kho ntawm cov tshuaj yog kwv yees raws li cov txiaj ntsig tiav, nrog ib lub sijhawm nruab nrab ntawm tsawg kawg 4 lub lis piam.

Pharmacological kev txiav txim

Synthetic hypolipidemic tus neeg sawv cev, muaj cov nyhuv hypocholesterolemic. Nws yog qhov sib tw inhibitor ntawm HMG-CoA reductase, uas hloov HMG-CoA rau mevalonate - ib qho kev qhia ua ntej rau sterols, tshwj xeeb hauv cov roj (cholesterol). Fluvastatin nqa tawm nws cov txiaj ntsig tseem ceeb hauv lub siab, yog kev sib tw ntawm 2 erythroenantiomers, uas ib qho muaj cov haujlwm pharmacological. Kev ua haujlwm ntawm cov roj synthesis txo nws cov tshuaj nyob rau hauv lub siab ua haujlwm, uas txhawb kev tsim ntawm LDL receptors thiab yog li ua rau kom muaj kev cuam tshuam ntawm circulating LDL particles los ntawm hepatocytes. Qhov kawg ntawm kev nqis tes ua yog txo qis ntshav ntawm tag nrho cov roj cholesterol, LDL roj cholesterol, apolipoprotein B thiab TG, nrog rau kev nce hauv HDL cov roj (cholesterol). Nws tsis muaj cov teebmeem mutagenic.

Cov nyhuv tau sau tseg tom qab 2 lub lis piam, nce mus txog nws qhov siab tshaj plaws nyob rau hauv 4 lub lis piam los ntawm kev pib kho thiab mob siab rau thoob plaws hauv kev kho mob.

Ua hauj lwm zoo thaum kws kho mob hais txog cov tshuaj tua kab mob.

Hauv cov neeg mob uas muaj mob rau cov hlab ntsha ua haujlwm nrog concomitant hypercholesterolemia (LDL-C 115-190 mg / dl), kev siv cov fluvastatin ntawm ib koob ntawm 40 mg / hnub rau 2.5 xyoo ua rau muaj kev vam meej ntawm cov mob coronary atherosclerosis.

Tam sim no, tsis muaj ntaub ntawv qhia txog kev siv fluvastatin hauv cov neeg mob homozygous tsev neeg hypercholesterolemia.

Sab sij huam

Nquag muaj tshwm sim ntawm cov kev mob tshwm sim: tshwm sim feem ntau - ntau dua 10%, tsis xws luag - 1-10%, tsis tshua muaj - txij li 0.001-1%, tsis tshua muaj tshwm sim - tsawg dua 0.001%.

Los ntawm lub plab zom mov: feem ntau - dyspepsia, xeev siab, mob plab, muaj mob tsawg kawg - kab mob siab.

Los ntawm cov kab mob hauv plab: feem ntau - mob taub hau, pw tsaug zog, ua tsis txaus ntseeg - paresthesia, hypesthesia, dysesthesia.

Ua xua: tsis tshua muaj pob - ua pob xua, urticaria, tsis tshua muaj tshwm sim - eczema, dermatitis, bullous exanthema, angioedema, lupus-like syndrome.

Los ntawm hemopoietic plab hnyuv siab raum: tsis tshua muaj tshwm sim - thrombocytopenia.

Los ntawm CCC: vasculitis.

Los ntawm cov leeg musculoskeletal: tsis tshua muaj - myalgia, leeg tsis muaj zog, myopathy, muaj tsawg - myositis, rhabdomyolysis.

Qhov ntsuas pom: qhov kev ua haujlwm ntau ntawm "daim siab" hloov pauv 3 zaug lossis ntau dua (1-2%), CPK ntau dua 5 zaug (0.3-1%).

Cov lus qhia tshwj xeeb

Ua ntej pib kev kho mob thiab tsis tseg nyob rau hauv cov txheej txheem kho, nws raug nquahu kom ua cov kev sim kab mob "siab". Yog tias qhov haujlwm ntawm AST lossis ALT yog siab dua 3 npaug ntawm VGN thiab tseem ruaj khov nyob rau hauv tus nqi no, kev kho yuav tsum tsis ua ntxiv.

Hauv cov neeg mob noj HMG-CoA reductase inhibitors, cov xwm txheej ntawm kev txhim kho myopathy tau piav qhia, suav nrog myositis thiab rhabdomyolysis. Myopathy tuaj yeem ntseeg tau rau hauv cov neeg mob uas tsis paub qhov tseeb tsis txaus myalgia, mob nqaij los yog tsis muaj zog thiab muaj qhov nce ntawm qhov ntau ntawm cov tshuaj CK, dhau qhov kev txwv siab tshaj qhov nruab nrab los ntawm ntau tshaj 10 zaug. Cov neeg mob yuav tsum tau qhia tam sim ntawd ib qho kev mob leeg, mob los yog mob leeg tsis muaj zog, tshwj xeeb tshaj yog tias lawv nrog mob malaise lossis kub taub hau. Nrog txoj kev nce qib hauv qhov kev xav ntawm CPK, kuaj mob myopathy lossis xav tias tsam myopathy, kev kho nrog fluvastatin yuav tsum nres tam sim ntawd.

Tam sim no, tsis muaj ntaub ntawv qhia txog kev siv fluvastatin hauv cov neeg mob homozygous tsev neeg hypercholesterolemia.

Hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm ntawm qhov mob hnyav thiab hauv cov neeg laus tsis muaj qhov xav tau yuav tsum tau nqa tawm kev kho kom haum. Tsis muaj kev paub dhau los ntawm kev siv fluvastatin hauv cov neeg muaj hnub nyoog qis dua 18 xyoo; nws tsis tuaj yeem pom zoo rau kev kho mob rau cov neeg mob ntawm pab pawg no.

Cov kev sim hauv nas thiab luav tsis tau qhia txog cov teebmeem teratogenic hauv fluvastatin. Txij thaum HMG-CoA reductase inhibitors txo qis kev sib xyaw ntawm cov roj (cholesterol) thiab, tejzaum nws, lwm yam tshuaj lom neeg lub cev - cov roj ntsha txhaws, lawv tuaj yeem tsim kev puas tsuaj rau menyuam hauv plab thaum cov tshuaj no tau sau tseg rau cov poj niam cev xeeb tub (yog tias cev xeeb tub tshwm sim thaum kho nrog pab pawg kws kho mob no, kev kho yuav tsum tsis ua ntxiv) Cov. Nws yuav tsum tau yug hauv siab tias thaum cov niam siv lovastatin (ib qho HMG-CoA reductase inhibitor) nrog dextroamphetamine nyob rau thawj peb lub hlis ntawm cev xeeb tub, yug menyuam ntawm cov pob txha deformation, mob tracheo-esophageal fistula, thiab anus atresia yog paub.

Kev tswjhwm zoo txog kev siv menyuam yaus yog tsis tuaj kawm ntawv.

Hauv kev sim tsiaj, muaj cov nyhuv carcinogenic ntawm cov tshuaj rau ntawm lub plab thiab lub qog ua haujlwm.

Nws yuav tsum tau nyob rau hauv lub siab tias kev coj ua ib txhij ntawm lovastatin (ib qho tshuaj tiv thaiv ntawm HMG-CoA reductase) nrog cyclosporine, tshuaj tua kab mob, fibrates (suav nrog gemfibrozil), ntau dua ntawm cov tshuaj nicotinic acid, immunosuppressants, macrolides ua rau muaj kev pheej hmoo ntawm rhabdomyolysis thiab mob raum tsis zoo, txawm hais tias tseem ceeb npaum li cas cov chaw muag tshuaj hauv kev sib cuam tshuam ntawm fluvastatin nrog cov tshuaj no tsis tau tshaj tawm.

Kev sib txuam

Tsis muaj qhov sib txawv hauv hypolipidemic nyhuv ntawm fluvastatin thaum noj thaum noj mov thaum yav tsaus ntuj lossis 4 teev tom qab nws. Fluvastatin tsis cuam tshuam nrog kua txiv kab ntxwv qaub (zoo ib yam li cov tshuaj uas tau hloov rau CYP3A4 isoenzyme).

Colestyramine thiab colestipol txo qis dua txog kev noj qab nyob zoo. Txhawm rau kom tsis txhob txo qis ntawm qhov nqus ntawm fluvastatin, nws yuav tsum tau sau tseg tsis pub dhau 4 teev tom qab noj cov kua tsib acid sequestrants (piv txwv li, colestyramine).

Nrog rau kev tswj hwm tib lub sijhawm ntawm fluvastatin nrog bezafibrate, gemfibrozil, ciprofibrate lossis nicotinic acid, tsis muaj kev hloov pauv tseem ceeb hauv kev siv bioavailability ntawm cov tshuaj no tau sau tseg.

Kev tswj hwm tib lub sijhawm nrog CYP3A4 cytochrome isoenzyme inhibitors (itraconazole thiab erythromycin) muaj qhov cuam tshuam loj heev txog qhov kev nyab xeeb ntawm lub cev ntawm fluvastatin (txij li CYP3A4 tsis ua si lub luag haujlwm tseem ceeb hauv cov fluvastatin metabolism, nws tuaj yeem xav tias lwm qhov tshuaj tiv thaiv ntawm no isoenzyme, ketocor cuam tshuam rau nws kev sib deev).

Cimetidine, ranitidine, lossis omeprazole kho mob me ntsis nce qhov kev nyab xeeb ntawm fluvastatin.

Rifampicin txo qis kev nyab xeeb ntawm fluvastatin los ntawm kwv yees li 50% (tam sim no tsis muaj pov thawj soj ntsuam los ntawm kev hloov pauv ntawm kev ua haujlwm ntawm fluvastatin thaum kws kho mob rau cov neeg mob tau txais kev kho mob ntev nrog rifampicin, txawm li cas los xij, ib qho kev tsim nyog koob tshuaj yuav tsum tau ua kom tau qhov txiaj ntsig uas xav tau).

Tseem ceeb txo cov Cmax ntawm rifampicin los ntawm 59%, AUC - los ntawm 51%, nce nws cov plasma tshem tawm los ntawm 95%.

Hauv cov neeg mob uas tau txais kev saib xyuas ruaj khov ntawm cov cyclosporine, tsis muaj qhov tseem ceeb hauv kev muaj peev xwm nce ntxiv ntawm kev noj qab haus huv ntawm fluvastatin raws li kev noj tshuaj ib hnub ib zaug txog li 40 mg. Fluvastatin, nyeg, tsis cuam tshuam rau kev mloog ntawm cyclosporine hauv cov ntshav.

Cov kev hloov pauv hauv lub chaw muag tshuaj ntawm phenytoin nrog kev tswj hwm ntawm fluvastatin yog ib qho me me thiab qhov tsis txaus ntseeg, thaum siv ua ke, ntshav ntau ntawm phenytoin yog saib xyuas, thiab koob tshuaj fluvastatin tsis tas yuav hloov pauv.

Hauv cov neeg mob uas muaj ntshav qab zib hom 2 tau txais kev kho mob nrog sulfonylurea derivatives (glibenclamide, tolbutamide), koom nrog fluvastatin kev kho mob tsis ua rau muaj kev hloov hauv chaw kho mob tseem ceeb.

Nws tuaj yeem ua rau muaj kev nce ntxiv hauv cov concentration ntawm digoxin, txawm li cas los xij, nrog kev siv tib lub sijhawm, tsis muaj qhov sib cuam tshuam ntawm cov chaw muag tshuaj nrog propranolol, digoxin, lossis losartan tau pom.

Ua ke nrog cov tshuaj warfarin thiab lwm cov tshuaj tua kab mob ntawm coumarin, qhov kev pheej hmoo los ntshav thiab / lossis lub sijhawm prothrombin nce ntxiv (nws raug nquahu kom tswj hwm lub sijhawm prothrombin thaum pib ntawm fluvastatin tswj hwm, thaum koob hloov pauv lossis tso tseg).

Cov lus nug, lus teb, tshuaj xyuas ntawm cov tshuaj Leskol forte

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Ntev-ua yeeb yuj ntsiav tshuaj	1 tab.
fluvastatin sodium	84.24 mg
(sib haum rau 80 mg ntawm fluvastatin)
tus neeg mob: MCC, hydroxypropylmethyl cellulose (hypromellose), hydroxypropyl cellulose (hyprolose), potassium bicarbonate, povidone, magnesium stearate, daj hlau oxide, macrogol, titanium dioxide

nyob rau hauv hlwv pob ntawm 7 lossis 14 pcs., hauv pob ntawv ib los yog 1 los yog 2 blisters (14 pcs.) lossis 4 blisters (7 pcs.).

Cov cim hauv qab no muaj tib lub ATC cov lis dej num. Cov lus piv txwv raug xaiv raws li cov qauv tshuaj ntawm cov tshuaj thiab yog cov hloov tau haum tshaj plaws. Cov sib xyaw zoo sib xws, kev taw qhia rau kev siv, cov koob tshuaj ntawm cov tshuaj nquag yuav sib txawv.

12 muaj pib ntawm 2,678. 00 rau 3,401. 00 rub

Tsuas tshuaj thiab tswj hwm

Sab hauv, tsis hais txog pluas noj, nqos tag nrho, nrog ib khob dej, 1 zaug hauv ib hnub. Txij li thaum fluvastatin tsis cuam tshuam nrog cov tshuaj uas yog cov kab mob sib kis rau CYP3A4 isoenzyme, nws txoj kev cuam tshuam nrog kua txiv kab ntxwv kua txiv tsis xav tau.

Tsis muaj qhov txo qis hauv cov nyhuv hypolipidemic fluvastatin thaum nws tau noj tshuaj lossis thaum 4 teev tom qab noj hmo.

Txij li qhov muaj txiaj ntsig hypolipidemic ntau kawg ntawm cov tshuaj tshwm sim los ntawm 4 lub lim tiam, thawj qhov kev ntsuam xyuas tshuaj ntawm cov tshuaj yog nqa los ntawm cov nyhuv ua tiav, nrog lub sijhawm tsawg kawg 4 lub lis piam. Kev kho mob kom zoo rau cov tshuaj Leskol® Forte raug tswj nrog nws siv ntev.

Ua ntej pib txoj kev kho mob nrog Leskol® Forte, tus neeg mob yuav tsum pauv mus rau ib qho kev noj haus hypocholesterol. Kev noj haus yuav tsum raug pom thaum lub sijhawm tag nrho ntawm kev kho mob.

Thawj koob tshuaj pom zoo yog 80 mg (1 ntsiav tshuaj. Leskol® Forte 80 mg) ib hnub ib zaug. Hauv qee qhov mob me me ntawm tus kab mob, ib koob tshuaj 20 mg fluvastatin yuav txaus (1 lub kaus mom. Leskol® 20 mg).

Rau cov neeg mob uas muaj mob plawv mob tom qab kev phais mob angioneoplastic, kev pom zoo pom zoo thawj zaug yog 80 mg / hnub.

Cov tshuaj Leskol® Forte siv tau zoo thaum siv los ua kev kho mob monotherapy. Muaj pov thawj ntawm qhov ua tau zoo thiab kev nyab xeeb ntawm fluvastatin thaum ua ke nrog nicotinic acid, colestyramine lossis fibrates.

Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo

Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog tshaj 9 xyoos hauv 6 lub hlis ua ntej pib kho nrog Leskol® Forte thiab thaum lub sijhawm tag nrho kev kho mob yuav tsum ua raws cov qauv hypocholesterol noj mov.

Qhov pom zoo kom muab thawj koob yog 80 mg (1 ntsiav tshuaj ntawm Leskol® Forte 80 mg) 1 zaug nyob rau ib hnub. Hauv qee qhov mob me me ntawm tus kab mob, ib koob tshuaj 20 mg fluvastatin yuav txaus (1 lub kaus mom. Leskol® 20 mg).

Kev siv cov fluvastatin ua ke nrog nicotinic acid, colestyramine lossis fibrates hauv cov menyuam yaus thiab cov hluas tsis tau kawm.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Txij li thaum fluvastatin tsuas yog tawm los ntawm daim siab thiab tsuas yog tsawg dua 6% ntawm cov koob tshuaj uas tau txais yog tawm hauv cov zis, hauv cov neeg mob uas tsis zoo lub raum kev ua haujlwm ntawm qhov mob hnyav, tsis tas yuav kho qhov tshuaj ntawm cov tshuaj.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Kev siv cov tshuaj Leskol Forte yog contraindicated nyob rau hauv kev mob siab daim siab lossis ua mob siab ntxiv nyob rau hauv cov concentration ntawm cov ntshav transaminases ntawm cov neeg tsis paub tab.

Cov neeg mob lub hnub nyoog qib siab. Kev ua tau zoo thiab zam tau zoo ntawm fluvastatin tau pom tias ua rau cov neeg mob hnub nyoog qis dua 65 xyoos thiab hluas dua lub hnub nyoog no. Hauv cov pab pawg hnub nyoog tshaj 65 xyoos, cov lus teb rau kev kho tau ntau dua, thaum tsis muaj ntaub ntawv qhia tias muaj kev ua siab phem ntxiv. Yog li, tsis tas yuav hloov pauv qhov koob tshuaj Leskol® Forte raws li lub hnub nyoog.

Cov qauv ntsuas tau phim ATC code qib 4. Cov tshuaj muaj tshuaj sib txawv, tab sis kuj yuav zoo sib xws hauv kev taw qhia thiab txoj kev siv.

68 muaj pib ntawm 51. 00 txog 922. 00 rub

46 muab pib ntawm 42. 00 txog 10.526. 00 rub

3 muab rau tus nqi ntawm 207. 00 txog 234. 00 rub

154 muaj pib txij 33. 00 txog 8.796. 00 rub

27 muab pib ntawm 129. 00 txog 502. 00 rub

115 muab pib thaum 5. 00 txog 179,000. 00 rub

37 muaj pib ntawm 10. 00 txog 2.602. 00 rub

138 muaj pib thaum 59. 00 txog 1,866. 00 rub

72 muaj pib ntawm 203. 00 txog 1,886. 00 rub

269 muaj pib txij 16. 00 txog 7.642. 00 rub

4 muab pib ntawm 104. 00 txog 785. 00 rub

14 muab pib thaum 6. 00 txog 602. 00 rub

32 muab pib thaum 7. 00 txog 1,089. 00 rub

9 muab pib ntawm 89. 00 txog 2,614. 00 rub

5 muab pib ntawm 253. 00 rau 377. 00 rub

123 muaj pib txij 45. 00 txog 17,780. 00 rub

70 muab pib ntawm 437. 00 txog 1,790. 00 rub

113 muaj pib ntawm 14. 00 txog 2,901. 00 rub

113 muaj pib ntawm 19. 00 rau 3,398. 00 rub

46 muab pib ntawm 324. 00 txog 1,407. 00 rub

66 muab pib thaum 7. 00 txog 1,660. 00 rub

7 muab rau tus nqi ntawm 51. 00 txog 556. 00 rub

12 muab pib ntawm 468. 00 txog 2,492. 00 rub

17 muab pib ntawm 298. 00 rau 1.396. 00 rub

37 muab pib txij 45. 00 txog 1,085. 00 rub

47 muaj pib ntawm 57. 00 txog 20,505. 00 rub

Lescol Forte: cov lus qhia thiab cov qauv tshuaj ntawm cov tshuaj

Nrog rau cov roj (cholesterol) siab, nws yog ib qho tseem ceeb kom xaiv txoj kev kho kom raug thiab kho kom raug txoj cai xaiv cov tshuaj. Cov tshuaj yuav tsum zoo, pheej yig, muaj qhov tsawg kawg ntawm kev phiv tshuaj.

Ib qho tshuaj nrov nrov uas daws cov lipids ntau heev yog Leskol Forte. Koj tuaj yeem yuav tau tom txhua lub tsev muag tshuaj, muab kws kho mob sau ntawv yuav. Cov tshuaj zoo li no tsis tsim nyog rau kev siv tshuaj rau tus kheej, vim tias yog koj xaiv qhov ntau thiab siv tsis tas, nws tuaj yeem ua rau lub cev tsis zoo.

Ua ntej siv cov tshuaj, nws yog ib qho tseem ceeb kom sab laj nrog kws kho mob uas yuav sau ntawv noj ntau npaum li cas, tsom rau tus neeg mob tus mob thiab keeb kwm kev kho mob. Feem ntau, Lescol Forte muaj kev tshuaj xyuas zoo heev los ntawm cov neeg mob thiab kws kho mob.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj qhia hauv daim duab yog fluvastatin. Qhov no yog hom tshuaj lipid-txo qis, uas zwm rau cov tshuaj tiv thaiv HMG-CoAreductases thiab muaj nyob hauv pawg ntawm statins. Cov lus sib xyaw kuj muaj xws li titanium dioxide, cellulose, potassium hydrogen carbonate, hlau oxide, magnesium stearate.

Koj tuaj yeem yuav cov tshuaj ntawm lub khw muag tshuaj lossis cov khw tshwj xeeb tom qab daim ntawv qhia muab tshuaj. Cov tshuaj kho mob yog tsim nyob rau hauv daim ntawv ntawm convex ntsiav tshuaj ntawm cov xim daj, tus nqi ntawm lawv yog 2600 rubles thiab siab dua.

Lub hauv paus ntsiab lus ntawm kev ua haujlwm ntawm kev kho mob nrog ntsiav tshuaj yog txhawm rau txhawm rau tsim cov cholesterol thiab txo nws cov nyiaj hauv lub siab. Vim li ntawd, qhov feem pua ntawm cov lipids teeb meem nyob rau hauv tus neeg mob ntshav plasma raug txo qis.

Yog tias koj niaj zaus noj Leskol Forte, qhov kev sib xyaw ntawm LDL yog txo 35 feem pua, cov roj (cholesterol) tag nrho - los ntawm 23 feem pua, thiab HDL los ntawm 10-15 feem pua.
Raws li kev soj ntsuam tau pom tias, hauv cov neeg mob mob plawv mob siv cov ntsiav tshuaj tau ob xyoos, kev ntsuas mob ntawm txoj hlab ntshav atherosclerosis tau pom.
Hauv cov neeg mob thaum kho, kev pheej hmoo ntawm kev tsim kab mob ntawm cov hlab plawv, myocardial infarction, lossis mob hlab ntsha tawg yog qhov txo qis.
Cov txiaj ntsig zoo sib xws tau pom hauv cov menyuam yaus uas kho nrog ntsiav tshuaj.

Txhawm rau kom tau cov ncauj lus kom ntxaws txog Leskol Fort, koj yuav tsum nyeem cov lus qhia rau kev siv tshuaj. Cov tshuaj tau noj ib hnub ib zaug nyob rau txhua lub sijhawm, tsis hais noj mov li cas. Cov ntsiav tshuaj tau nqos tag nrho thiab ntxuav nrog kua ntau hauv lub cev.

Qhov tshwm sim ntawm kev ua ntawm cov tshuaj tuaj yeem pom tsis dhau plaub lub lis piam tom qab, thaum cov nyhuv ntawm kev kho mob tseem nyob ntev.

Ua ntej pib kev kho mob, tus neeg mob yuav tsum ua raws li kev noj zaub mov zoo hypocholesterol, uas tseem muaj cuam tshuam thoob plaws chav kawm.

Cov koob tshuaj yog xaiv los ntawm tus kws kho mob, coj mus rau hauv tus account tus yam ntxwv ntawm lub cev thiab qhov ntsuas ntawm teeb meem lipids.

Hauv cov khoom muaj mob plawv ua tom qab kev phais mob, ib ntsiav tshuaj ib hnub tseem siv.

Cov tshuaj LescolForte tau pom zoo kom tsis txhob sib xyaw nrog lwm cov tshuaj hauv pawg no. Lub caij no, kev tau txais cov tshuaj ntxiv ntawm fibrates, nicotinic acid thiab cholestyramine raug tso cai rau noj ntau npaum li cas.
Cov menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog tshaj li cuaj xyoos tuaj yeem kho tau nrog cov ntsiav tshuaj sib luag nrog cov neeg laus, tab sis ua ntej ntawd, nws yog ib qho tseem ceeb kom noj zaub mov kom raug thiab nrog zaub mov noj tshuaj kom muaj rau lub hlis.
Txij li cov tshuaj tawm hauv kev tawm tsam tsuas yog nrog kev koom tes ntawm daim siab, cov neeg mob uas lub raum tsis ua haujlwm yuav tsis tuaj yeem hloov kho koob tshuaj.
Kev noj cov tshuaj yog contraindicated yog tias muaj kab mob hauv lub raum, ib cov neeg pheej hloov zuj zus ntxiv ntawm cov keeb kwm tsis paub tseeb.

Raws li kev tshawb nrhiav, ntsiav tshuaj thiab tshuaj ntsiav muaj txiaj ntsig txhua hnub nyoog. Qhov no tseem muaj pov thawj los ntawm ntau cov kev txheeb xyuas zoo. Tab sis koj yuav tsum xav txog tias cov tshuaj muaj ntau qhov tshwm sim uas koj yuav tsum paub ua ntej.

Khaws cov tshuaj nyob ntawm qhov kub tsis tshaj 25 degrees, kom txav deb ntawm tshav ntuj ncaj qha thiab menyuam yaus. Lub txee lub neej ntawm cov ntsiav tshuaj yog ob xyoos.

Leskol Forte yog siv rau hypercholesterolemia, dyslipidemia, atherosclerosis, ntxiv rau kev tiv thaiv cov kab mob plawv. Rau cov menyuam yaus hnub nyoog tshaj 9 xyoos, kev kho mob tau qhia nyob rau hauv muaj cov roj ntsha keeb thawj txoj kev tsis haum cov lipid metabolism.

Noj tshuaj yog contraindicated yog tias muaj pathology ntawm daim siab thiab lub raum, kev fab tshuaj rau cov tshuaj nquag thiab cov feem ntawm cov tshuaj. Koj tsis tuaj yeem nqa tawm kev kho mob thaum cev xeeb tub thiab pub niam mis.

Tsis muaj cov tsos mob ntawm kev haus ntau tshaj tau qhia txog lub sijhawm no. Txawm li cas los xij, cov ntsiav tshuaj tuaj yeem muaj txhua yam kev mob tshwm sim hauv daim ntawv ntawm:

Vasculitis nyob rau hauv feem ntau tsis tshua muaj neeg mob,
Thrombocytopenia
Mob taub hau, parasthesia, hypesthesia, lwm yam kev cuam tshuam ntawm cov hlab ntshav hlwb,
Kab mob siab nyob rau hauv qee kis tshwj tsis yog, dyspeptic cuam tshuam,
Dermatological mob
Myalgia, myopathy, rhabdomyolysis,
Kev nce tsib-npaug hauv creatine phosphokinase, qhov peb zaug yuav ntxiv rau hauv transmiasis.

Kev saib xyuas tshwj xeeb yuav tsum tau saib xyuas los ntawm cov neeg quav cawv, thiab nrog lub siab ua haujlwm rau daim siab. Xws li nws tsis tas yuav tsum ua txoj kev kho mob rau rhabdomyolysis, mob leeg mob mus ntev, kev txheeb xyuas qhov tshwm sim ua ntej ntawm kev tsis zoo ntawm lub cev mus rau statins.

Ua ntej koj pib noj tshuaj, koj yuav tsum kuaj xyuas lub siab. Tom qab ob lub lim tiam, kuaj ntshav tso tawm.

Yog tias qhov kev ua ntawm AST thiab ALT nce ntxiv ntau dua peb zaug, koj yuav tsum tsis kam lees noj tshuaj.

Thaum tus neeg mob tau lub qog ua kab mob ntshav, ua haujlwm rau lub siab thiab lub raum, kev quav dej cawv, kev tshawb xyuas ntxiv yog coj los hloov CPK.

Muab qhov tseeb tias cov tshuaj muaj txiaj ntsig fluvastatin tsis cuam tshuam nrog lwm cov tshuaj, nws tuaj yeem raug coj los ua ke nrog lwm cov ntsiav tshuaj. Tab sis thaum siv qee cov tshuaj, koj yuav tsum them sai sai rau qee cov ntsej muag.

Hauv kev tshwj xeeb, noj Rimfapicin tib lub sijhawm, Leskol Forte maj mam txo cov nyhuv ntawm lub cev.

Tsis tas li, qee zaum kev qhia txog kev noj qab haus huv raug txo los ntawm 50 feem pua, hauv qhov no, tus kws kho mob kho qhov kev xaiv tshuaj lossis xaiv ib qho kev kho mob sib txawv.

Thaum kho nrog Omeprazole thiab Ranitidine, uas siv rau kev cuam tshuam ntawm lub plab hnyuv, ntawm qhov tsis tooj, qhov nqus ntawm fluvastatin ntau zog, uas ua rau muaj kev cuam tshuam ntawm cov ntsiav tshuaj ntawm lub cev.

Cov tshuaj Leskol Forte muaj ntau cov tshuaj yeeb yaj kiab, thaum lub sijhawm tam sim no muaj ntau dua li 70 li ntawm cov ntsiav tshuaj, cov tshuaj nquag ntawm uas yog fluvastatin.

Cov nqi pheej yig yog Astin, Atorvastatin-Teva thiab Vasilip, lawv tus nqi yog 220-750 rubles. Tsis tas li ntawd hauv cov chaw muag tshuaj koj tuaj yeem nrhiav cov statins Atoris, Torvakard, Livazo, lawv muaj txog tus nqi ib yam li 1,500 rubles.

Yuav kom siv tshuaj ntau dua suav nrog Krestor, Rosart, Liprimar, cov tshuaj zoo li no yuav raug nqi 2000-3000 rubles.

Cov kev siv hluav taws xob ntau muaj xws li Rosuvastatin thiab Atorvastatin, Lovastatin, Simvastatin, Fluvastatin, Pravastatin muaj kev siv khov kho.

Txhua yam tshuaj no tuaj yeem ua thooj, tab sis tib neeg lub cev ib txwm teb ib qho zoo dua rau ib hom tsiaj twg. Yog li, cov kws kho mob feem ntau pom zoo sim ob peb statins thiab xaiv ib qho uas ua haujlwm zoo dua.

Nyob rau lub sijhawm no, muaj plaub tiam ntawm cov tshuaj rau cov cholesterol siab.

Cov tshuaj thib 1 suav nrog Simgal, Zovotin, Lipostat, Cardiostatin, Rovacor. Cov ntsiav tshuaj zoo li ntawd muaj cov lipid-txo cov nyhuv, uas yog, lawv txo qhov kev sib txuas ntawm cov lipids uas muaj kev phom sij thiab tiv thaiv lawv cov kev sib txuam hauv cov hlab ntshav. Tus nqi ntawm triglycerides kuj txo qis thiab cov concentration ntawm cov roj (cholesterol) yuav nce ntxiv. Cov tshuaj yeeb yaj kiab tau siv rau hauv kev kho mob ntawm cov mob pob txha ntshav atherosclerosis.
Leskol Forte belongs rau lub cim 2 tiam statins, nws ua rau lub zog tsim cov lipoproteins ntau ntom, uas thaum kawg ua rau txo qis hauv cov concentration ntawm lipids thiab triglycerides. Cov tshuaj feem ntau tau sau tseg rau hypercholesterolemia, thiab tseem tuaj yeem pom zoo raws li prophylactic rau cov kab mob ntawm cov hlab plawv.
Cov tshuaj thib 3 yog siv yog tias kev noj tshuaj kho mob thiab kev tawm dag zog tsis pab. Cov no yog Liprimar, Tulip, Anvistat, Lipobay, Torvakard, Atomaks, Atorvaks. Nrog rau cov tshuaj no suav hais tias yog kev tiv thaiv zoo rau kev mob plawv, ntshav qab zib mellitus, kab mob plawv. Cov txiaj ntsig ntawm kev kho tuaj yeem pom tom qab ob lub lis piam.
Qhov ua tau zoo tshaj plaws thiab tsis tshua muaj phom sij rau lub cev yog statins ntawm 4 tiam. Lawv muaj pes tsawg yam kev tiv thaiv thiab kev phiv, yog li cov ntsiav tshuaj tuaj yeem siv suav nrog kev kho mob menyuam yaus. Hauv qhov no, qhov ntau npaum li cas yog tsawg, thiab cov tshwm sim tuaj yeem pom hauv ob peb hnub. Cov no suav nrog cov tshuaj xws li Acorta, Tevastor, Roxer, Krestor, Mertenir, Livazo.

Tsuas yog tus kws kho mob tau tuaj yeem txiav txim siab seb cov ntsiav tshuaj twg tsim nyog siv tom qab kawm txog keeb kwm kho mob thiab cov txiaj ntsig kev kuaj mob.

Txhawm rau kev kho kom zoo, statins yuav tsum tau ua ntu zus.

Tab sis nws yog ib qho tseem ceeb los saib xyuas tus neeg mob lub sijhawm txhua hnub kom tiv thaiv kev txhim kho ntawm qhov tsis xav tau, vim tias cov tshuaj hauv pab pawg no muaj ntau cov kev mob tshwm sim.

Statins tau piav qhia hauv daim video hauv kab lus no.

Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo. Nrhiav tsis pom. Nrhiav. Nrhiav tsis pom. Pom. Nrhiav tsis pom.

Nyob rau qhov kub thiab txias tsis tshaj 25 ° C.

Khaws tsis ncav cuag ntawm cov menyuam yaus.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Leskol Forte: cov ncauj lus kom ntxaws ntawm cov tshuaj

Ua ntej koj yuav xav txog dab tsi Leskol Forte cov lus qhia rau kev siv, peb yuav sau cov ntaub ntawv tseem ceeb hais txog cov khoom. Lub thoob ntiaj teb lub npe ntawm cov tshuaj yog fluvastatin.

Los ntawm pab pawg koom nrog, cov tshuaj belongs rau qeb ntawm lipid-txo cov tshuaj, subcategory - HMG-CoA reductase inhibitors. Cov tshuaj nquag ntawm cov tshuaj yog fluvastatin - ib tus neeg sawv cev hluavtaws uas zwm rau pawg pab pawg ntawm statins.

Cov tshuaj muaj nyob hauv ntsiav tshuaj daim ntawv, tsos - convex daj ntsiav tshuaj, ntawm ib sab ntawm cov ntawv uas yog sau LE, nyob rau sab tod - NVR.

Cov tshuaj ntim rau hauv cov hlwv - muaj ob pob 2 blisters, txhua tus muaj 14 ntsiav tshuaj, muaj pob 4 lub blisters thiab 7 ntsiav tshuaj nyob hauv txhua tus.

Ntxiv rau cov khoom xyaw tseem ceeb (fluvastatin sodium ntsev), cov ntsiav tshuaj kuj tseem muaj cov tshuaj pab - cellulose, titanium dioxide, hlau oxide (uas muab cov ntsiav tshuaj daj xim), potassium hydrogen carbonate thiab magnesium stearate.

Qhov tshwm sim ntawm kev siv Leskol Forte

Cov neeg mob uas muaj dyslipidemia thiab hypercholesterolemia uas tau siv tshuaj rau 24 lub lis piam pom cov txiaj ntsig hauv qab no: muaj kev txo qis hauv tag nrho cov roj (cholesterol) 23%, cov ntshav ntawm LDL tsawg dua 34%, thiab cov tshuaj HDL nce ntxiv yuav luag 10%.

Cov neeg mob uas pib roj HDL tsawg yuav ua tiav nce li 13-14%.

Qhov kev ua tau zoo ntawm cov tshuaj nce mus txog nws qhov siab tshaj plaws twb tau nyob rau thaum xaus ntawm lub lim tiam thib ob, lub toj siab ntawm cov hauj lwm zoo kav ntev dua li ob lub lis piam, thiab kev siv Lescol Forte tseem txuas ntxiv txhua lub sijhawm.

Ib qho ntxiv, kev siv cov tshuaj tsis tu ncua nrog kev ntseeg siab ua rau muaj kev txo qis txaus ntshai ntawm txhua qhov kev pheej hmoo mob plawv rau lub plawv, yog tias nws kho mob plawv, mob plawv, xav tau cov hlab ntshav o hla kev sib tsoo.

Ua tsaug rau fluvastatin muaj nyob hauv cov tshuaj, qhov ntxim nyiam ntawm lub plawv nres lossis cia li nres lub plawv sai dua yog 31%.

Kev siv cov tshuaj los ntawm cov menyuam yaus tseem pom tias muaj txiaj ntsig zoo - qhov LDL cov ntsiab lus hauv cov ntshav txo qis 5%:

Thaum lub siab heev ntawm LDL (ntau dua 4.9 mmol / litre),
Nrog lub siab xav (los ntawm 4.1 mmol / litre) thiab muaj ntau qhov kev pheej hmoo rau cov ntshav siab cov ntshav siab, piv txwv li, ntshav qab zib, haus luam yeeb, ntshav siab, thiab ua kom pom cov kab mob plawv thaum ntxov.
Ntawm qhov kev ntsuas ntawm tsawg dua 4.1 mmol / litre thiab muaj qhov ntsuas pom ntawm qhov tsis xws ntawm theem noob.

Txais Tos Leskol Forte rau cov menyuam yaus txij li 9 xyoo tsis muaj kev phom sij - tsis muaj kev phiv xws li kev loj hlob stunted thiab kev loj hlob, kev tsis muaj kev sib deev.

Nco ntsoov tias cov kev tshawb pom saum toj no tsis tuaj yeem coj los ua lub hauv paus rau kev ntsuas ntawm kev kho rau cov menyuam yaus hnub nyoog qis dua 9 xyoos.

Cov nyhuv Pharmacokinetic

Xav txog Leskol Forte, cov lus qhia rau kev siv yuav tsum muaj cov ntaub ntawv hais txog pharmacokinetics ntawm cov tshuaj. Xav txog cov ntaub ntawv tseem ceeb ntawm qhov teeb meem no.

Fluvastatin muaj cov nqi nqus tau zoo. Kev txais sab hauv cov tshuaj hauv qhov kev daws teeb meem yog nrawm thiab yuav luag yaim - qhov feem pua yog 98%.

Raws li rau Leskol Forte, cov txheej txheem nqus tau kav 60% ntev dua vim yog cov lus tshaj tawm ntev ntawm cov tshuaj. Cov tshuaj yeeb dej caw yog nyob rau hauv cov ntshav 4 teev. Ib cov tshuaj noj tom qab noj mov muaj qhov txo qis nqus tsawg dua. Qhov ntsuas kev qhia txog ntawm tus ciam yog 24%.

Kev zom zaub mov

Lub ntsiab ntawm cov metabolism hauv kev tshwm sim hauv lub siab. Cov cheebtsam uas nkag mus rau hauv cov hlab ntshav yog fluvastatin thiab ib qho me me ntawm cov tshuaj tsis haum-metabolite - desisopropyl-propionic acid.

Cov txheej txheem ntawm kev hloov pauv ntawm cov tshuaj nquag tsis cuam tshuam nrog cytochrome P450, thiab yog li ntawd cov nqi hauv metabolic tsis nyob ntawm lwm cov tshuaj uas ua rau cytochrome 450. Fluvastatin nws tus kheej yog qhov inhibitor ntawm CYP2C9 isoenzyme.

Nws yog tawm hauv ib txwm - txog 95% yog dhau los ntawm cov quav thiab txog 5% - los ntawm tso zis. Lub plasma tshem tawm hauv tus neeg mob noj tshuaj yog 1.8 l / m.

Cov xwm txheej tshwj xeeb ntawm cov tshuaj pharmacokinetics

Lub sijhawm ntawm noj Leskol Forte tsis ua lub luag haujlwm tseem ceeb - noj cov tshuaj ua ntej noj hmo thiab 4 teev tom qab nws tsis pom muaj kev hloov hauv AUC.

Tus tub los ntxhais thiab lub hnub nyoog ntawm tus neeg mob kuj tsis yog ib txoj luag haujlwm hauv kev txiav txim siab qhov kub siab ntawm cov tshuaj nquag. Txawm li cas los xij, qhov ua tau zoo ntawm cov tshuaj me ntsis nce ntxiv hauv cov neeg laus.

Kev ntsuas rau nkag

Kev qhia siv rau cov laus yog:

Hypercholesterolemia thiab dyslipidemia, yog tias kho nrog kev noj zaub mov noj,
Hypercholesterolemia thiab atherosclerosis, suav nrog tsis yog hais tau meej heev
Kev tiv thaiv cov kab mob plawv.

Cov menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog tshaj 9 xyoos tuaj yeem siv cov tshuaj yog tias muaj tsev neeg hypercholesterolemia.

Siv tau tshuaj

Leskol Forte tsuas noj ib zaug ib hnub, tsis hais txog lub sijhawm noj mov. Cov ntsiav tshuaj yog ntxuav nrog dej. Qhov siab tshaj plaws ntawm cov tshuaj tau mus txog tsuas yog 4 lub lim tiam ntawm kev txais, yog li ntawd, kev tshuaj xyuas cov tshuaj noj tuaj yeem tsuas yog nyob tom qab lub sijhawm saum toj no.

Ua ntej tus kws kho mob sau ntawv yuav cov tshuaj, tus neeg mob yuav tsum mus noj cov zaub mov tshwj xeeb uas tau tsim los rau tej roj. Nws yuav tsum raug kuaj txhua lub sijhawm thaum tus neeg mob noj Leskol Forte.

Qhov pom zoo kom tsuas ntau yog 80 mg, thiab yog tias muaj mob mentsis, nws txaus los noj 20 mg. Cov koob tshuaj siv rau ob tus menyuam yaus thiab tus neeg laus.

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj tuaj yeem cuam tshuam nrog nicotinic acid thiab fibrates (cov pov thawj ua tau zoo).

Ntxiv rau, cov cuab yeej tuaj yeem raug siv los ua tus neeg sawv cev rau cov neeg sab nraud.

Cov tshuaj ntawm cov tshuaj thiab cov nqi

Ua ntej tshaj plaws, peb xav txog dab tsi yog cov piv txwv ntawm Leskol Forte. Tag nrho cov tshuaj teev tseg hauv qab no, peb tau xaiv raws li ATC kev faib tawm cov tshuaj.

Cov tshuaj phiv tshuaj ntawm tshuaj yog fluvastatin. Txhua qhov xaiv tau tso tawm kom haum rau qib plaub ntawm qib ATC, txawm hais tias muaj pes tsawg leeg, uas yuav txawv hauv qee cov tshuaj, raws li kev taw qhia thiab cov hau kev.

Lub sijhawm no, muaj txog 70 analogues rau ntawm kev ua lag luam - xav txog qee ntawm lawv:

Atoris - txij li 195 txog 1200 rubles,
Vasilip - los ntawm 136 txog 785 rubles,
Krestor - los ntawm 347 txog 19400 rubles,
Liprimar - los ntawm 200 txog 2800 rubles,
Torvakard - los ntawm 237 txog 1500 rubles,
Livazo - txij li 455 txog 1440 rubles,
Rosart - los ntawm 370 txog 2400 rubles,
Astin - los ntawm 87 txog 220 rubles,
Atorvastatin-Teva - los ntawm 93 txog 597 rubles.
Tus nqi nruab nrab ntawm Leskol Forte yog 2800 rubles.

Cov tshuaj ua haujlwm li cas?

Lub hauv paus ntsiab lus ntawm kev ua haujlwm ntawm kev kho mob nrog ntsiav tshuaj yog txhawm rau txhawm rau tsim cov cholesterol thiab txo nws cov nyiaj hauv lub siab. Vim li ntawd, qhov feem pua ntawm cov lipids teeb meem nyob rau hauv tus neeg mob ntshav plasma raug txo qis.

Yog tias koj niaj zaus noj Leskol Forte, qhov kev sib xyaw ntawm LDL yog txo 35 feem pua, cov roj (cholesterol) tag nrho - los ntawm 23 feem pua, thiab HDL los ntawm 10-15 feem pua.
Raws li kev soj ntsuam tau pom tias, hauv cov neeg mob mob plawv mob siv cov ntsiav tshuaj tau ob xyoos, kev ntsuas mob ntawm txoj hlab ntshav atherosclerosis tau pom.
Hauv cov neeg mob thaum kho, kev pheej hmoo ntawm kev tsim kab mob ntawm cov hlab plawv, myocardial infarction, lossis mob hlab ntsha tawg yog qhov txo qis.
Cov txiaj ntsig zoo sib xws tau pom hauv cov menyuam yaus uas kho nrog ntsiav tshuaj.

Cov lus qhia rau kev siv

Qhov tshwm sim ntawm kev ua ntawm cov tshuaj tuaj yeem pom tsis dhau plaub lub lis piam tom qab, thaum cov nyhuv ntawm kev kho mob tseem nyob ntev.

Ua ntej pib kev kho mob, tus neeg mob yuav tsum ua raws li kev noj zaub mov zoo hypocholesterol, uas tseem muaj cuam tshuam thoob plaws chav kawm.

Thaum xub thawj, nws raug nquahu kom noj ib ntsiav tshuaj 80 mg. Yog tias tus mob no tsis hnyav, nws txaus siv 20 mg ib hnub twg, nyob rau hauv rooj plaub no cov tshuaj ntsiav tau. Cov koob tshuaj yog xaiv los ntawm tus kws kho mob, coj mus rau hauv tus account tus yam ntxwv ntawm lub cev thiab qhov ntsuas ntawm teeb meem lipids. Hauv cov khoom muaj mob plawv ua tom qab kev phais mob, ib ntsiav tshuaj ib hnub tseem siv.

Cov tshuaj LescolForte tau pom zoo kom tsis txhob sib xyaw nrog lwm cov tshuaj hauv pawg no. Lub caij no, kev tau txais cov tshuaj ntxiv ntawm fibrates, nicotinic acid thiab cholestyramine raug tso cai rau noj ntau npaum li cas.
Cov menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog tshaj li cuaj xyoos tuaj yeem kho tau nrog cov ntsiav tshuaj sib luag nrog cov neeg laus, tab sis ua ntej ntawd, nws yog ib qho tseem ceeb kom noj zaub mov kom raug thiab nrog zaub mov noj tshuaj kom muaj rau lub hlis.
Txij li cov tshuaj tawm hauv kev tawm tsam tsuas yog nrog kev koom tes ntawm daim siab, cov neeg mob uas lub raum tsis ua haujlwm yuav tsis tuaj yeem hloov kho koob tshuaj.
Kev noj cov tshuaj yog contraindicated yog tias muaj kab mob hauv lub raum, ib cov neeg pheej hloov zuj zus ntxiv ntawm cov keeb kwm tsis paub tseeb.

Khaws cov tshuaj nyob ntawm qhov kub tsis tshaj 25 degrees, kom txav deb ntawm tshav ntuj ncaj qha thiab menyuam yaus. Lub txee lub neej ntawm cov ntsiav tshuaj yog ob xyoos.

Leej twg qhia rau kho

Noj tshuaj yog contraindicated yog tias muaj pathology ntawm daim siab thiab lub raum, kev fab tshuaj rau cov tshuaj nquag thiab cov feem ntawm cov tshuaj. Koj tsis tuaj yeem nqa tawm kev kho mob thaum cev xeeb tub thiab pub niam mis.

Tsis muaj cov tsos mob ntawm kev haus ntau tshaj tau qhia txog lub sijhawm no. Txawm li cas los xij, cov ntsiav tshuaj tuaj yeem muaj txhua yam kev mob tshwm sim hauv daim ntawv ntawm:

Vasculitis nyob rau hauv feem ntau tsis tshua muaj neeg mob,
Thrombocytopenia
Mob taub hau, parasthesia, hypesthesia, lwm yam kev cuam tshuam ntawm cov hlab ntshav hlwb,
Kab mob siab nyob rau hauv qee kis tshwj tsis yog, dyspeptic cuam tshuam,
Dermatological mob
Myalgia, myopathy, rhabdomyolysis,
Kev nce tsib-npaug hauv creatine phosphokinase, qhov peb zaug yuav ntxiv rau hauv transmiasis.

Ua ntej koj pib noj tshuaj, koj yuav tsum kuaj xyuas lub siab. Tom qab ob lub lim tiam, kuaj ntshav tso tawm. Yog tias qhov kev ua ntawm AST thiab ALT nce ntxiv ntau dua peb zaug, koj yuav tsum tsis kam lees noj tshuaj. Thaum tus neeg mob tau lub qog ua kab mob ntshav, ua haujlwm rau lub siab thiab lub raum, kev quav dej cawv, kev tshawb xyuas ntxiv yog coj los hloov CPK.

Hauv kev tshwj xeeb, noj Rimfapicin tib lub sijhawm, Leskol Forte maj mam txo cov nyhuv ntawm lub cev.

Tsis tas li, qee zaum kev qhia txog kev noj qab haus huv raug txo los ntawm 50 feem pua, hauv qhov no, tus kws kho mob kho qhov kev xaiv tshuaj lossis xaiv ib qho kev kho mob sib txawv.

Thaum kho nrog Omeprazole thiab Ranitidine, uas siv rau kev cuam tshuam ntawm lub plab hnyuv, ntawm qhov tsis tooj, qhov nqus ntawm fluvastatin ntau zog, uas ua rau muaj kev cuam tshuam ntawm cov ntsiav tshuaj ntawm lub cev.

Analogues ntawm cov tshuaj

Cov tshuaj Leskol Forte muaj ntau cov tshuaj yeeb yaj kiab, thaum lub sijhawm tam sim no muaj ntau dua li 70 li ntawm cov ntsiav tshuaj, cov tshuaj nquag ntawm uas yog fluvastatin.

Yuav kom siv tshuaj ntau dua suav nrog Krestor, Rosart, Liprimar, cov tshuaj zoo li no yuav raug nqi 2000-3000 rubles.

Dab tsi hom statins nyob ua ib ke

Cov kev siv hluav taws xob ntau muaj xws li Rosuvastatin thiab Atorvastatin, Lovastatin, Simvastatin, Fluvastatin, Pravastatin muaj kev siv khov kho.

Qee cov tshuaj hauv pawg no koom nrog lwm cov tshuaj. Yog li, piv txwv li, Atorvastatin, Pravastatin thiab Simvastatin tsis tuaj yeem siv tom qab haus cov kua txiv kab ntxwv qaub, qhov no tuaj yeem ua rau muaj kev phom sij. Qhov tseeb yog tias cov kua txiv qaub ua rau cov kua txiv ntau ntxiv nyob rau hauv cov ntshav.

Nyob rau lub sijhawm no, muaj plaub tiam ntawm cov tshuaj rau cov cholesterol siab.

Cov tshuaj thib 1 suav nrog Simgal, Zovotin, Lipostat, Cardiostatin, Rovacor. Cov ntsiav tshuaj zoo li ntawd muaj cov lipid-txo cov nyhuv, uas yog, lawv txo qhov kev sib txuas ntawm cov lipids uas muaj kev phom sij thiab tiv thaiv lawv cov kev sib txuam hauv cov hlab ntshav. Tus nqi ntawm triglycerides kuj txo qis thiab cov concentration ntawm cov roj (cholesterol) yuav nce ntxiv. Cov tshuaj yeeb yaj kiab tau siv rau hauv kev kho mob ntawm cov mob pob txha ntshav atherosclerosis.
Leskol Forte belongs rau lub cim 2 tiam statins, nws ua rau lub zog tsim cov lipoproteins ntau ntom, uas thaum kawg ua rau txo qis hauv cov concentration ntawm lipids thiab triglycerides. Cov tshuaj feem ntau tau sau tseg rau hypercholesterolemia, thiab tseem tuaj yeem pom zoo raws li prophylactic rau cov kab mob ntawm cov hlab plawv.
Cov tshuaj thib 3 yog siv yog tias kev noj tshuaj kho mob thiab kev tawm dag zog tsis pab. Cov no yog Liprimar, Tulip, Anvistat, Lipobay, Torvakard, Atomaks, Atorvaks. Nrog rau cov tshuaj no suav hais tias yog kev tiv thaiv zoo rau kev mob plawv, ntshav qab zib mellitus, kab mob plawv. Cov txiaj ntsig ntawm kev kho tuaj yeem pom tom qab ob lub lis piam.
Qhov ua tau zoo tshaj plaws thiab tsis tshua muaj phom sij rau lub cev yog statins ntawm 4 tiam. Lawv muaj pes tsawg yam kev tiv thaiv thiab kev phiv, yog li cov ntsiav tshuaj tuaj yeem siv suav nrog kev kho mob menyuam yaus. Hauv qhov no, qhov ntau npaum li cas yog tsawg, thiab cov tshwm sim tuaj yeem pom hauv ob peb hnub. Cov no suav nrog cov tshuaj xws li Acorta, Tevastor, Roxer, Krestor, Mertenir, Livazo.

Tsuas yog tus kws kho mob tau tuaj yeem txiav txim siab seb cov ntsiav tshuaj twg tsim nyog siv tom qab kawm txog keeb kwm kho mob thiab cov txiaj ntsig kev kuaj mob. Txhawm rau kev kho kom zoo, statins yuav tsum tau ua ntu zus. Tab sis nws yog ib qho tseem ceeb los saib xyuas tus neeg mob lub sijhawm txhua hnub kom tiv thaiv kev txhim kho ntawm qhov tsis xav tau, vim tias cov tshuaj hauv pab pawg no muaj ntau cov kev mob tshwm sim.

Statins tau piav qhia hauv daim video hauv kab lus no.