Lizoril - (Lisoril) cov lus qhia rau siv

Kev piav qhia cuam tshuam rau 28.12.2014

• Lub npe Latin: Lisinopril
• ATX Code: C09AA03
• Yam tshuaj muaj sia: Lisinopril (Lisinopril)
• Chaw tsim tshuaj paus: Avant (Ukraine), Skopinsky Pharmaceutical Plant, ALSI Pharma, ZiO-Zdorovye, Severnaya Zvezda, Ozon LLC, Biochemist, Obolenskoye - chaw tsim tshuaj lag luam, Canonfarm Ntau lawm CJSC, VERTEX (Russia)

Lub hauv paus tseem ceeb ntawm cov tshuaj yog lisinopril dihydrateCov. Tab sis, nyob ntawm tus tsim cov tshuaj, cov tshuaj sib xyaw cov tshuaj ntxiv yuav sib txawv.

Lub tuam txhab Ukrainian Avant tsim Lisinopril nrog cov ntu ntu xws li pob kws nplej siab,calcium hydrogen phosphate,hlau oxide, mannitol,magnesium stearate.

Thiab Lavxias chaw tsim tshuaj paus ALSI Pharma ua khoom lag luam nrog cov khoom lag luam ntxiv hauv qab no: pregelatinized hmoov txhuv nplej siab,silicon dioxide colloidal,talcum hmoov,lactose monohydrate, microcrystalline cellulose,magnesium stearate.

Tsis tas li ntawd, xws li cov ntawv tso tawm ntawm cov tshuaj yeej paub zoo li Lisinopril-Ratiopharm, Lisinopril-Astrafarm, Lisinopril Teva, Lisinopril Stada. Lawv muaj cov hauv qab no ntxiv:

• Lisinopril-Astrapharm - pob kws nplej siab,silicon dioxide colloidal,mannitol,calcium hydrogen phosphate, magnesium stearate,
• Lisinopril-Ratiopharm - mannitol,calcium hydrogen phosphate, magnesium stearate, pregelatinized hmoov txhuv nplej siab, croscarmellose sodium (20 mg ntsiav tshuaj tseem muaj cov xim PB-24824, thiab cov tshuaj hauv cov ntsiav tshuaj 10 mg muaj cov xim PB-24823).

Lisinopril Stada muaj cov khoom xyaw ua si lisinopril hydrateCov. Thiab ntxiv rau, cov yeeb tshuaj hauv qab no ntxiv: pregelatinized hmoov txhuv nplej siab,silicon oxide colloidal anhydrous, mannitol,magnesium stearate,pob kws nplej siab, calcium phosphate disubstituted dihydrate.

Pharmacodynamics thiab pharmacokinetics

Lisinopril ntsiav tshuaj thaiv ACEnce cov ntsiab lus endogenous vasodilating GHG thiab tabkaum qhov kev hloov pauv angiotensin Kuv hauv angiotensin IICov. Lawv tseem txo qis hloov dua siab tshiab. arginine-vasopressinthiab endothelin-1, txo myocardial afterload, tag nrho peripheral vascular tsis kam, mob ntsws pulmonary capillary thiab cov ntshav muaj zog. Hauv cov neeg mob nrog lub plawv tsis ua hauj lwm nce myocardial kam rau ua kom tawm dag zog thiab qhov tso zis tshwm simCov. Pab txhawb nqa kom muaj ntau ntxiv renin ntshav.

Cov tshuaj thaiv cov ntaub so ntswg renin-angiotensin lub siab ua haujlwm, tiv thaiv cov tsos ntawm myocardial hypertrophy thiab dhuav sab laug ventricle lossis pab hauv lawv kev ploj.

Cov nyhuv ntawm cov tshuaj tshwm sim tom qab li 60 feeb, nce rau 6-7 teev thiab kav rau ib hnub. Qhov ntau antihypertensivecov nyhuv ua tau nws tus kheej hauv ob peb lub lis piam.

Cov tshuaj yeeb dej caw yog nqus los ntawm kwv yees li 25%. Lub sijhawm noj mov tsis cuam tshuam rau qhov nqus. Kev sib txuas lus nrog cov protein ntshav yog qhov tsawg. Cov tshuaj tseem ceeb tsis yog biotransformed thiab raug tshem tawm los ntawm ob lub raum tsis hloov. Qhov kev tshem tawm ib nrab-lub neej yog 12 teev.

Cov Yuav Tsum Muaj

Cov tshuaj yuav tsum tsis txhob noj nrog kev tiv thaiv tsis haum rau nws lub Cheebtsam, kev pub mis thiab cev xeeb tub.

Nws yog qhov tsim nyog yuav tau sau tshuaj rau cov tshuaj no rau:

• hyperkalemia,
• anaphylactoid kev tsis haum,
• collagenoses,
• cerebrovascular tsis txaus,
• raum tsis ua haujlwm thiab lub siab ua haujlwm,
• ob leeg lub raum leeg mob stenosis,
• hloov raum
• mob gout,
• laus lawm
• Quincke's edema hauv keeb kwm,
• mob hlwb pob txha kev nyuaj siab,
• hypotension,
• obstructive kev hloov uas tiv thaiv outflow ntshav tawm hauv nruab siab
• tshuaj mob siab ntsws, nrog rau thaum noj nrog qhov muaj ntsev tsawg,
• ib lub raum artery stenosis,
• hyperuricemia,
• cov me nyuam muaj hnub nyoog.

Sab sij huam

Cov kev mob tshwm sim tuaj yeem sib txawv, lawv tshwm sim los ntawm cov kab ke sib txawv thiab cov plab hnyuv siab raum:

Ntxiv rau, cov kev tshwm sim hauv qab no yog ua tau: kev txhim kho ntawm kev kis mob, poob phaus, hws, mob ntshav qab zib mellituskev tsa tshuaj tua kab mob antinuclear titer thiab cov ntsiab lus urea, mob goutqib nce neeg tsim tswv, hyperkalemia, hyperuricemia, npaws, kev fab tshuaj, lub cev qhuav dej, tshuaj mob siab ntsws.

Yog tias muaj lwm cov kev mob tshwm sim, koj yuav tsum tau sab laj nrog ib tus kws kho mob tshwj xeeb.

Noj ntau dhau

Nyob rau hauv cov ntaub ntawv ntawm overdose, raws li txoj cai, tshwm mob hlab ntsha tawg hypotensionCov. Raws li kev kho mob, physiological saline yog ua haujlwm. Kev kho mob tshwm sim.

Tsis tas li, poob siab yog ua tau, hyperventilation, mob raum tsis ua haujlwm, bradycardia, hnoos, tsis txaus electrolytes hauv cov ntshav tachycardialub plawv dhia kiv taub haukev ntxhov siab.

Cov tshuaj yuav tsum tau tshem tawm. Yog tias tus neeg mob nco qab, lawv yaug lub plab, muab tus neeg mob tso rau ntawm nws sab nraub qaum nrog taub hau qis, tsa ceg thiab taub hau tsa ib sab. Tsis tas li, lawv muab enterosorbents.

Thaum noj tshuaj tshwj xeeb hauv kev txhaj tshuaj ntau, tus neeg mob yuav tsum tau mus pw hauv tsev kho mob sai. Hauv tsev kho mob, kev kho mob yog ua tiav ntawm kev saib xyuas ib txwm muaj siab kawg nkaus, cov ntshav ncig, ua pa, rov qab los ntawm cov ntim ntawm lub cev ntshav thiab lub raum kev ua haujlwm. Siv tau hemodialysisCov. Nco ntsoov soj ntsuam cov ntsuas ntawm cov haujlwm tseem ceeb, ntxiv rau qib neeg tsim tswv thiab electrolytesnyob rau hauv cov ntshav dej.

Kev sib txuam

Noj cov tshuaj nrog antihypertensivetshuaj noj tuaj yeem ua rau tuaj yeem ntxiv cov nyhuv antihypertensive.

Poov tshuaj-sparing diuretics, hloov rau cov ntsev noj tau nrog poov tshuaj, thiab cov tshuaj uas muaj cov poov tshuaj ntau ntxiv ua tau hyperkalemia.

Ua ke nrog blockers ACE thiab NSAIDstsub kom muaj feem ntawm lub raum puas. Tsawg tsawg zaus, nws tseem muaj peev xwm ua tau hyperkalemia.

Thiab daim ntaub ntawv nyob rau hauv nrog rovqab thiab thiazide diuretics fraught nrog amplification antihypertensive ntawv. Qhov no tseem cuam tshuam ntawm kev pheej hmoo ntawm lub raum kev ua haujlwm.

Indomethacin lossis cov nyiaj nrog tshuaj estrogen ua ke nrog lisinopril ua rau kom txo qis antihypertensive kev ua ntawm yav tas. Ib txhij txais tos Cov tshuaj insulin thiabtshuaj qog ntshav tshuaj yuav ua tau ntshav qog.

Kev sib xyaw nrog clozapine ua rau muaj kev nce ntxiv hauv nws cov ntsiab lus hauv plasma. Thaum noj lithium carbonate nws qib hauv cov ntshav dej nce ntxiv. Qhov no tuaj yeem nrog cov tsos mob ntawm lithium intoxication.

Cov tshuaj kuj tseem nce cov nyhuv ntawm ethanol. Cov tsos mob ntawm intoxication yog aggravated. Nyob rau tib lub sijhawm, muaj qhov nce ntxiv yog qhov ua tau antihypertensive cov nyhuv ntawm lisinopril, yog li nws yog qhov yuav tsum tsis txhob haus dej cawv thaum kho nrog cov tshuaj no lossis tsis txhob noj nws hauv 24 teev tom qab haus cawv.

Siv cov tshuaj no hauv ua ke nrog Tshuaj loognarcotic analgesics, tshuaj tiv thaiv kab mob, leeg ua kom mob nrog hypotensive kev txiav txim, nrog rau kev noj tshuaj tsaug zog ua rau muaj kev nce ntxiv antihypertensive nyhuv.

Thrombolytics nce ntxiv kom ua tau zoo arterial hypotensionCov. Qhov kev sib xyaw no yuav tsum tau txiav txim siab nrog ceev faj thiab ua tib zoo saib xyuas tus neeg mob lub mob.

Sympathomimetics zoo heev tsis muaj zog antihypertensive cov nyhuv ntawm cov tshuaj. Kev sib xyaw nrog cov tshuaj uas muab tau myelosuppressiveua kom muaj kev pheej hmoo agranulocytosis thiab / lossis neutropenia.

Concomitant siv nrog Allopurinol, txhaj tshuaj tiv thaiv kab mob, Procainamide, cytostatics, corticosteroids tej zaum yuav ua rau leukopenia.

Ntawm lim ntshavtshuaj los kho tau anaphylactoid kev tsis haum nyob rau hauv cov ntaub ntawv ntawm daim ntawv thovsiab ntws polyacrylonitrile hlau sulfonate pwm.

Tso tawm daim ntawv, ntim thiab muaj pes tsawg leeg Lizoril ®

10 Pcs. - blister packs (3) - pob ntawv ntawm cardboard.
14 pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.

Tshwjxeeb: hmoov txhuv nplej siab, mannitol, dicalcium phosphate dihydrate, magnesium stearate, hlau zas xim oxide liab.

10 Pcs. - hlwv (3) - pob khoom los ntawm cardboard.
14 pcs. - hlwv (2) - pob khoom los ntawm cardboard.

Tshwjxeeb: hmoov txhuv nplej siab, mannitol, dicalcium phosphate dihydrate, magnesium stearate, hlau zas xim oxide liab.

10 Pcs. - blister packs (3) - pob ntawv ntawm cardboard.
14 pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.

Tshwjxeeb: hmoov txhuv nplej siab, mannitol, dicalcium phosphate dihydrate, magnesium stearate, hlau zas xim oxide liab.

10 Pcs. - blister packs (3) - pob ntawv ntawm cardboard.
14 pcs. - blister packagings (2) - pob ntawv los ntawm cardboard.

Pharmacological kev txiav txim

ACE inhibitor. Nws inhibits qhov tsim ntawm angiotensin II los ntawm angotensin I. Nws txo cov ntsiab lus ntawm angiotensin II thiab ua rau txo qis ncaj qha rau kev tso tawm ntawm aldosterone. Txo txo ​​cov kev ua haujlwm ntawm bradykinin thiab nce prostaglandin synthesis. Txo tag nrho peripheral vascular tsis kam, ntshav siab, preload, pulmonary capillary siab, ua rau muaj kev nce siab hauv cov hlab plawv tawm thiab nce myocardial zam rau kev ntxhov siab hauv cov neeg mob plawv tsis ua haujlwm. Nthuav cov hlab ntsha mus rau qhov ntau dua li cov leeg ntshav. Qee qhov cuam tshuam tau piav qhia los ntawm cov nyhuv rau cov ntaub so ntswg renin-angiotensin. Nrog rau siv ntev, hypertrophy ntawm myocardium thiab phab ntsa ntawm cov hlab ntsha ntawm hom tiv thaiv poob qis. Txhim kho cov ntshav xa mus rau ischemic myocardium. ACE inhibitors lengthen lub neej nyob rau hauv cov neeg mob uas lub plawv tsis ua hauj lwm thiab qeeb qhov kev vam meej ntawm sab laug ventricular kawg nyob hauv cov neeg mob tom qab myocardial infarction yam tsis muaj kev kho mob ua rau pom lub plawv tsis ua haujlwm.

Qhov pib ntawm kev ua yog nyob rau hauv 1 teev. Qhov siab tshaj plaws tau txiav txim siab tom qab 6-7 teev, ntev ntev - 24 teev. Nrog kev mob ntshav tawm ntawm cov leeg, cov nyhuv yog pom nyob hauv thawj hnub tom qab pib kho, qhov ua tau zoo tshwm sim tom qab 1-2 lub hlis

Cov Tshuaj Pharmacokinetics

Lub bioavailability ntawm cov tshuaj yog 25-50%, tsis muaj zog khi rau cov protein plasma. C max hauv dej ntshiab tau mus txog tom qab 7 teev. Kev noj tsis cuam tshuam rau kev nqus.

Kev tso cai hla dhau ntawm BBB thiab qhov chaw nruab siab tsis tshua muaj.

Lysoril tsis yog metabolized thiab ua rau tsis hloov pauv ntawm cov zis. Feem ntau ntawm nws tau tso tawm thaum thawj theem (pib T 1/2 - 12 teev), tom qab ntawd los ntawm lub davhlau ya nyob twg theem (T 1/2 li 30 teev)

Tsuas tshuaj thiab tswj hwm

Sab hauv. Ntawm Cov leeg ntshav siab: qhov tshuaj thawj zaug yog 5 mg ib hnub ib zaug, yog tias tsim nyog txog 40 mg / hnub. Ntawm congestive heart tsis ua hauj lwm: qhov kev pib siv yog 2.5 mg, yog tias xav tau txog 20 mg / hnub. Tawm tsam keeb kwm yav dhau los ntawm kev ua txhaum ntawm cov dej-electrolyte tshuav, diuretic txoj kev kho mob ntawm lub raum tsis ua haujlwm, nrog kev kho cov ntshav rov qab kho mob, thawj koob yog 1.25 mg / hnub.

Cov ntsiab lus ntawm nosological pawg

Tso koj saib

Cov Ntaub Ntawv Tam Sim No Xav Tau Index, ‰

Kev Tso Npe Lizoril

• P N014842 / 01-2003

Lub vev xaib raug cai ntawm lub tuam txhab RLS ®. Lub encyclopedia tseem ceeb ntawm cov tshuaj thiab cov khoom muag ntawm cov khw muag tshuaj assortment ntawm Lavxias Internet. Daim ntawv teev cov tshuaj Rlsnet.ru muab cov neeg siv kev nkag mus rau cov lus qhia, tus nqi thiab cov lus piav qhia txog cov tshuaj, khoom noj tshuaj, khoom siv kho mob, khoom siv kho mob thiab lwm yam khoom lag luam. Cov lus qhia ntawm pharmacological suav nrog cov ntaub ntawv ntawm kev sib xyaw thiab daim ntawv tso tawm, kev nqis tes ua pharmacological, kev taw qhia rau kev siv, contraindications, kev phiv tshuaj, cuam tshuam tshuaj, hom kev siv tshuaj, cov tuam txhab tshuaj. Daim ntawv qhia cov tshuaj muaj nqi rau tshuaj thiab cov khoom lag luam tshuaj hauv Moscow thiab lwm lub nroog Lavxias.

Nws yog txwv tsis pub xa, theej, tshaj tawm cov ntaub ntawv yam tsis tau txais kev tso cai los ntawm RLS-Patent LLC.
Thaum hais cov ntaub ntawv xov xwm luam tawm nyob rau ntawm nplooj ntawv ntawm lub xaib www.rlsnet.ru, qhov txuas mus rau qhov chaw ntawm cov ntaub ntawv xav tau.

Ntau ntau yam nthuav

Qoob loo.

Kev ua lag luam siv cov ntaub ntawv tsis raug tso cai.

Cov ntaub ntawv yog npaj rau cov kws kho mob.

Kev ntsuas rau siv

Arterial hypertension (suav nrog cov tsos mob), CHF, kev kho mob thaum ntxov ntawm tus mob myocardial infarction hauv cov neeg mob hemodynamically ruaj khov (ua ib feem ntawm txoj kev kho ua ke).

Raws li ib feem ntawm kev sib xyaw ua ke rau kev kho tus mob myocardial infarction (hauv thawj 24 teev, nrog hemodynamics ruaj khov).

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, nrog txoj hlab ntshav tawg - 5 mg ib hnub ib zaug. Thaum tsis muaj txiaj ntsig, qhov koob tshuaj tau nce ntxiv txhua 2-3 hnub los ntawm 5 mg rau qhov nruab nrab cov tshuaj kho 20-40 mg / hnub (nce qhov koob tshuaj saum toj 20 mg / hnub feem ntau tsis ua rau txo qis ntshav siab). Qhov nyiaj pab ntau tshaj txhua hnub yog 80 mg.

Nrog HF - pib nrog 2.5 mg ib zaug, tom qab ntawd koob tshuaj nce siab dua 2.5 mg tom qab 3-5 hnub.

Hauv cov neeg laus, ib qho kev tshaj tawm ntev dua hypotensive nyhuv yog feem ntau pom, uas cuam tshuam nrog kev txo qis ntawm lisinopril excretion (nws tau pom zoo kom pib kho nrog 2.5 mg / hnub).

Hauv kev mob raum tsis ua haujlwm, kev sib txuam tau tshwm sim nrog qhov txo tsawg dua lim pom tsawg dua 50 ml / min (qhov koob tshuaj yuav tsum raug txo 2 zaug, nrog CC tsawg dua 10 ml / min, qhov tshuaj yuav tsum raug txo 75%).

Nrog cov kev mob ntshav siab ntev, kev kho mob mus ntev yog qhia ntawm 10-15 mg / hnub, nrog lub plawv tsis ua haujlwm - 7,5-10 mg / hnub.

Cov lus qhia tshwj xeeb

Kev saib xyuas tshwj xeeb yog yuav tsum tau ua thaum muab tshuaj rau cov neeg mob uas muaj ob lub raum mob ntshav ntawm lub raum lossis stenosis ntawm tib lub raum leeg (tej zaum kev nce ntawm urea thiab creatinine hauv cov ntshav), cov neeg mob ua mob rau cov hlab ntshav hlab plawv lossis kab mob cerebrovascular, nrog decompensated lub plawv tsis ua hauj lwm (ua tau hypotension, myocardial infarction, stroke). Hauv cov neeg mob uas lub plawv tsis ua hauj lwm, txoj hlab ntshav hauv txoj hlab ntshav tuaj yeem ua rau lub raum khiav tsis zoo.

Thaum siv cov tshuaj uas txo cov ntshav siab hauv cov neeg mob nrog kev phais mob ntau lossis thaum lub sijhawm tso tshuaj loog, lisinopril tuaj yeem thaiv kev tsim cov tshuaj angiotensin II, theem nrab kom them nyiaj rov qab muaj kev paub meej.

Kev nyab xeeb thiab ua haujlwm ntawm lisinopril hauv menyuam yaus tseem tsis tau teeb tsa.

Ua ntej pib kev kho mob, nws yog qhov tsim nyog kom them nyiaj rau qhov poob ntawm cov kua dej thiab cov ntsev.

Siv thaum cev xeeb tub yog contraindicated, tshwj tsis yog nws tsis tuaj yeem siv lwm yam tshuaj lossis lawv tsis muaj txiaj ntsig (tus neeg mob yuav tsum tau txais kev ceeb toom txog kev pheej hmoo rau tus menyuam hauv plab).

Cov lus nug, lus teb, tshuaj xyuas ntawm cov tshuaj Lizoril

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Sab sij huam

Los ntawm cov hlab plawv: txo cov ntshav siab, mob hauv siab, tsis tshua muaj - orthostatic hypotension, tachycardia, bradycardia, qhov tshwm sim ntawm cov tsos mob ntawm lub plawv tsis ua haujlwm, tsis ua haujlwm ntawm atrioventricular conduction.

Los ntawm cov hlab ntsha hauv lub cev: kiv taub hau, mob taub hau, qaug zog, tsaug zog, txhaws qa ntawm cov leeg ntawm nqaj thiab daim di ncauj, tsis tshua muaj tshwm sim - asthenic syndrome, mus ob peb vas lab, tsis meej pem.

Los ntawm kev mob plab hnyuv: xeev siab, dyspepsia, tsis nco qab, hloov pauv, mob plab, zawv plab, qhov ncauj qhuav.

Hematopoietic plab hnyuv siab raum: leukopenia, thrombocytopenia, neutropenia, agranulocytosis, ntshav liab (qis hemoglobin, erythrocytopenia).

Los ntawm kev ua pa: dyspnea, bronchospasm, apnea.

Ua xua: angeoneurotic edema, tawv nqaij ua pob, khaus.

Qhov ntsuas pom: hyperkalemia, hyperuricemia, tsis tshua muaj - nce kev ua haujlwm ntawm "kab mob siab" hloov ntshav, hyperbilibinemia.

Lwm yam, hnoos qhuav, tsis muaj potency, tsis tshua muaj - mob raum tsis ua haujlwm, mob pob txaws, mob pob txha, ua npaws, edema (tus nplaig, daim di ncauj, nqaj), qhov tsis zoo ntawm kev loj hlob ntawm lub raum fetal.

Daim ntawv thov nta

Kev saib xyuas tshwj xeeb yog yuav tsum tau ua thaum muab tshuaj rau cov neeg mob uas muaj ob lub raum mob ntshav ntawm lub raum lossis stenosis ntawm tib lub raum leeg (tej zaum kev nce ntawm urea thiab creatinine hauv cov ntshav), cov neeg mob ua mob rau cov hlab ntshav hlab plawv lossis kab mob cerebrovascular, nrog decompensated lub plawv tsis ua hauj lwm (mob ntshav siab, mob ntshav qab zib, mob hlab ntsha tawg). Hauv cov neeg mob uas lub plawv tsis ua hauj lwm, txoj hlab ntshav hauv txoj hlab ntshav tuaj yeem ua rau lub raum khiav tsis zoo.

Kev txo qis hauv cov ntshav siab thaum kho mob feem ntau tshwm sim nrog qhov kev txo qis hauv BCC tshwm sim los ntawm kev kho diuretic, kev txwv kev noj ntsev, kev lim ntshav, raws plab, lossis ntuav.

Kev kho nrog lisinopril nyob rau hauv kev mob siab myocardial infarction yog nqa tawm ntawm keeb kwm ntawm kev kho mob (thrombolytics, ASA, beta-blockers). Siv tau nrog iv kev tswj hwm ntawm nitroglycerin lossis TTC nitroglycerin.

Thaum siv cov tshuaj uas txo cov ntshav siab hauv cov neeg mob nrog kev phais mob ntau los yog thaum lub sijhawm tso tshuaj loog, lisinopril tuaj yeem thaiv kev tsim cov tshuaj angiotensin II, theem nrab kom them nyiaj rov qab muaj kev paub meej. Ua ntej kev phais mob (suav nrog kev phais hniav), tus kws phais mob / tshuaj loog yuav tsum paub txog kev siv tshuaj ACE inhibitor.

Raws li cov txiaj ntsig ntawm kev tshawb fawb txog kev mob sib kis, nws tau xav tias kev siv ACE inhibitors thiab tshuaj insulin ib txhij, nrog rau cov tshuaj tiv thaiv kab mob hauv qhov ncauj, tuaj yeem ua rau kev txhim kho hypoglycemia. Qhov kev pheej hmoo loj tshaj plaws ntawm kev txhim kho tau pom nyob rau thawj lub lim tiam ntawm kev sib txuam, nrog rau cov neeg mob uas lub raum tsis ua haujlwm. Cov neeg mob ntshav qab zib yuav tsum tau saib xyuas glycemia, tshwj xeeb tshaj yog thaum thawj lub hlis ntawm kev kho mob nrog ACE inhibitor.

Ua ntej pib kev kho mob, nws yog qhov tsim nyog kom them nyiaj rau qhov poob ntawm cov kua dej thiab cov ntsev.

Cov kev pheej hmoo txaus rau kev loj hlob ntawm hyperkalemia muaj xws li mob raum tsis ua haujlwm, mob ntshav qab zib mellitus thiab kev siv cov poov tshuaj-sparing (spironolactone, triamteren lossis amiloride), K + kev npaj lossis ntsev hloov chaw uas muaj K +. Kev tshuaj xyuas qee zaus ntawm kev saib xyuas ntawm K + hauv cov ntshav ntshav yog kev pom zoo.

Hauv cov neeg mob noj ACE inhibitors thaum lub sijhawm hymenopter, nws yog ib qho kev tsis tshua muaj kev phom sij txog kev phom sij ntawm lub cev. Nws yog ib qho tsim nyog yuav tsum tau txiav tawm ib ntus kev kho mob nrog ACE inhibitor ua ntej pib ib txoj kev kawm desensitization.

Kev phiv tshuaj anaphylactoid tej zaum yuav tshwm sim thaum hemodialysis tau ua los ntawm kev siv cov qib siab ua kua (nrog rau AN 69). Nws yog qhov tsim nyog los xav txog kev siv lwm hom qog ua rau lim ntshav lossis lwm yam tshuaj tiv thaiv kab mob siab.

Kev nyab xeeb thiab ua haujlwm ntawm lisinopril hauv cov menyuam yaus tseem tsis tau txhim tsa.