Cov lus qhia ua qauv - cov lus qhia rau kev siv, sib piv, tshuaj xyuas thiab tso cov ntawv tso tawm (QuickPen cwj mem kua tov nrog kev daws lossis ncua kev sib xyaw ntawm Mix 25 thiab 50 insulin) ntawm cov tshuaj rau kev kho mob ntawm hom 1 thiab hom 2 mob ntshav qab zib hauv cov laus, menyuam yaus thiab thaum cev xeeb tub

Hauv tsab xov xwm no, koj tuaj yeem nyeem cov lus qhia rau kev siv tshuaj yaj yeeb Neej NeegCov. Muab cov lus pom zoo los ntawm cov neeg tuaj saib rau ntawm thaj chaw - cov neeg tau txais kev pab ntawm cov tshuaj no, nrog rau kev xav ntawm cov kws kho mob tshwj xeeb txog kev siv Humalog hauv lawv cov kev coj ua. Qhov kev thov loj yog nquag ntxiv kev tshuaj xyuas koj ntawm cov tshuaj: cov tshuaj tau pab lossis tsis pab ua kom tshem tawm ntawm tus kabmob, muaj dab tsi tshwm sim thiab cov kev mob tshwm sim, tejzaum nws tsis tshaj tawm los ntawm tus tsim khoom hauv cov lus piav qhia. Cov Txiaj Ntsig ntawm Humalog nyob rau hauv muaj cov qauv txheej txheem qauv. Siv rau kev kho mob ntawm hom 1 thiab hom 2 mob ntshav qab zib mellitus (ntshav qab zib-insulin thiab tsis-insulin-mob ntshav qab zib) rau cov neeg laus, menyuam, nrog rau lub sijhawm cev xeeb tub thiab lactation. Cov tshuaj muaj pes tsawg leeg.

Neej Neeg - cov duab ntawm cov tshuaj insulin, txawv ntawm nws los ntawm kev rov qab ua ntu zus ntawm cov kab sib luag thiab lysine amino acid seem ntawm txoj haujlwm 28 thiab 29 ntawm cov kab insulin B. Piv nrog luv luv ua yeeb yam npaj cov tshuaj insulin, lyspro insulin yog tus yam ntxwv sai dua ntawm qhov pib thiab qhov kawg ntawm cov nyhuv, uas yog vim muaj kev nqus ntxiv los ntawm subcutaneous depot vim yog kev txuag ntawm monomeric qauv ntawm lyspro insulin lwg me me hauv cov tshuaj. Qhov pib ntawm kev ua yog 15 feeb tom qab tswj hwm subcutaneous, qhov ua haujlwm siab tshaj plaws yog nruab nrab ntawm 0.5 teev thiab 2.5 teev, lub sijhawm ua ntawm 3-4 teev.

Humalog Mix yog DNA - recombinant analogue ntawm tib neeg cov kua dej thiab yog qhov sib xyaw ua ke uas muaj lyspro insulin tov (kev ua kom sai ntawm tib neeg cov tshuaj insulin) thiab kev ncua ntawm lyspro protamine insulin (nruab nrab ntev tib neeg cov tshuaj insulin).

Kev ua tseem ceeb ntawm insulin lyspro yog kev cai ntawm cov metabolism hauv cov piam thaj. Tsis tas li ntawd, nws muaj anabolic thiab anti-catabolic cuam tshuam rau ntau cov ntaub so ntswg lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm cov ntsiab lus ntawm glycogen, fatty acids, glycerol, kev nce ntawm synthesis protein thiab kev nce ntawm kev noj cov amino acids, tab sis tib lub sijhawm muaj glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids.

Muaj pes tsawg leeg

Lyspro insulin + excipients.

Cov Tshuaj Pharmacokinetics

Kev ua tiav ntawm kev nqus thiab pib ntawm cov nyhuv ntawm cov tshuaj insulin nyob ntawm qhov chaw txhaj tshuaj (plab, ncej, pob tw), qhov koob tshuaj (ntim ntawm txhaj tshuaj insulin), thiab qhov tob ntawm cov tshuaj insulin hauv kev npaj. Nws tau faib tawm tsis ncaj hauv daim ntaub. Nws tsis hla tus cwj pwm ntawm lub tso mis thiab nkag rau hauv niam mis. Nws yog rhuav tshem los ntawm insulinase feem ntau hauv daim siab thiab lub raum. Nws yog tawm los ntawm lub raum - 30-80%.

Cov Khoom Qhia

yam 1 mob ntshav qab zib mellitus (insulin-dependant), suav nrog nrog kev tsis nkag siab rau lwm txoj kev npaj tshuaj insulin, nrog postprandial hyperglycemia uas tsis tuaj yeem kho los ntawm lwm yam kev npaj tshuaj insulin, mob subcutaneous insulin tsis kam (nrawm hauv lub zos insulin degradation),
yam 2 mob ntshav qab zib mellitus (non-insulin-dependant): nrog kev tawm tsam cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj, nrog rau kev nqus tsis tau ntawm lwm yam tshuaj insulin, kev tiv thaiv tsis tau zoo tom qab hyperglycemia, thaum lub sijhawm ua haujlwm, cov kabmob sib kis.

Tso Tawm Cov Ntawv

Ib qho kev daws teeb meem rau kev tswj hwm kom haum thiab subcutaneous ntawm 100 IU hauv 3 ml cartridge sib xyaw rau hauv QuickPen cwj mem los yog cwj mem kua txho.

Ncua rau kev rho tawm ntawm 100 IU hauv 3 ml cartridge sib xyaw rau hauv QuickPen cwj mem los yog cwj mem kua (Humalog Mix 25 thiab 50).

Lwm cov ntaub ntawv ntau npaum li cas, tsis pub muaj ntsiav tshuaj lossis tsiav tshuaj, tsis muaj nyob.

Cov lus qhia rau kev siv thiab qauv ntawm kev siv

Qhov ntau npaum li cas tau teev cia ua ib tus zuj zus. Lyspro insulin yog muab tshuaj subcutaneously, intramuscularly lossis intravenously 5-15 feeb ua ntej noj mov. Ib koob tshuaj yog 40 units, ntau dhau tsuas tso cai tshwj xeeb. Nrog rau cov tshuaj tua kab mob, Lyspro insulin muab rau 4-6 zaug hauv ib hnub, ua ke nrog kev npaj tshuaj insulin ntev - 3 zaug hauv ib hnub.

Cov tshuaj yuav tsum tau muab tshuaj subcutaneously.

Tso dej siab tswj hwm ntawm cov tshuaj Humalog Mix yog contraindicated.

Qhov ntsuas kub ntawm cov tshuaj tso cai yuav tsum nyob ntawm chav sov.

Subcutaneously yuav tsum nkag mus rau hauv lub xub pwg, ncej puab, pob tw los yog lub plab. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib qhov chaw siv tsis ntau tshaj 1 zaug hauv ib hlis. Thaum s / qhia txog cov tshuaj Humalog, kev saib xyuas yuav tsum tau saib xyuas kom tsis txhob txais cov tshuaj rau hauv cov hlab ntsha. Tom qab txhaj tshuaj, qhov chaw txhaj tshuaj yuav tsum tsis txhob zaws.

Thaum txhim kho lub taub hau hauv lub twj txhaj tshuaj insulin thiab txuas lub koob ua ntej insulin thawj coj, cov lus qhia ntawm cov chaw tsim khoom ntawm cov cuab yeej siv tshuaj insulin yuav tsum ua raws cai.

Cov kev cai rau kev qhia ntawm cov tshuaj Humalog Mix

Npaj rau kev qhia

Tam sim ntawd ua ntej siv, Humalog Mix sib xyaw cartridge yuav tsum tau muab sib dhos ntawm xib teg kaum npaug thiab tshee, tig ntawm 180 ° kuj kaum zaus kom rov kho cov tshuaj insulin kom txog thaum nws zoo li homogeneous huab lossis kua mis. Tsis txhob co khov kho, raws li qhov no tuaj yeem ua rau npuas dej, uas tuaj yeem cuam tshuam nrog cov koob tshuaj kom raug. Txhawm rau kom yooj yim rau kev sib xyaw, lub pob txha taub ntawv muaj lub khob iav me me. Cov tshuaj yuav tsum tsis txhob siv yog tias nws muaj plaub yaig tom qab tov.

Yuav siv cov tshuaj li cas

Ntxuav tes.
Xaiv ib qho chaw rau kev txhaj tshuaj.
Kho cov tawv nqaij nrog tshuaj tua kab mob ntawm qhov chaw txhaj tshuaj (nrog rau kev coj tus kheej, raws li tus kws kho mob cov lus pom zoo).
Tshem lub hau tiv thaiv sab nraud ntawm rab koob.
Txhim kho cov tawv nqaij los ntawm rub nws los yog khi cov quav loj.
Ntxig lub koob txhaj tshuaj subcutaneously thiab ua qhov kev txhaj tshuaj raws li cov lus qhia siv kev siv tus xaum xim.
Tshem tawm rab koob thiab maj mam muab nyem qhov chaw txhaj tshuaj rau ob peb feeb. Tsis txhob txhuam thaj chaw txhaj tshuaj.
Siv lub hau sab tiv thaiv ntawm rab koob, unscrew lub koob thiab rhuav tshem nws.
Tso lub hau rau ntawm tus cwj mem xaum qhuav.

Sab sij huam

hypoglycemia (mob ntshav qab zib heev tuaj yeem ua rau tsis nco qab thiab, tshwj tsis yog mob tuag taus),
liab, o, lossis khaus ntawm qhov chaw txhaj tshuaj (feem ntau ploj hauv ob peb hnub lossis lim tiam, qee qhov xwm txheej no tuaj yeem yog vim los ntawm tsis muaj feem cuam tshuam nrog insulin, piv txwv li, voos tawv nqaij los ntawm kev siv tshuaj tua kab mob los yog kev txhaj tshuaj tsis zoo),
dav khaus
ua pa nyuaj
txog siav
txo hauv cov ntshav siab,
tachycardia
nce hws
kev txhim kho ntawm lipodystrophy ntawm thaj chaw txhaj tshuaj.

Cov Yuav Tsum Muaj

qog ntshav,
ua kom lub cev tsis haum rau cov tshuaj ntawm cov tshuaj.

Cev xeeb tub thiab lactation

Txog hnub, tsis muaj qhov xav tau ntawm Lyspro insulin ntawm cev xeeb tub lossis qhov xwm txheej ntawm tus menyuam hauv plab thiab cov menyuam tshiab tau pom.

Lub hom phiaj ntawm kev kho tshuaj insulin thaum cev xeeb tub yog kom tswj tau cov piam thaj kom txaus. Qhov kev xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thiab nce hauv qib thib ob thiab thib peb thaum cev xeeb tub. Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau.

Cov poj niam ntawm lub hnub nyoog yug menyuam uas muaj ntshav qab zib yuav tsum qhia tus kws kho mob txog qhov pib lossis npaj yuav xeeb tub.

Hauv cov neeg mob uas mob ntshav qab zib mellitus thaum pub niam mis, yuav tsum tau txhaj tshuaj insulin thiab / lossis noj zaub mov kom haum.

Cov lus qhia tshwj xeeb

Cov kab ke ntawm cov thawj coj npaj rau kev siv ntau npaum ntawm lyspro insulin yuav tsum nruj me ntsis. Thaum hloov mus rau cov neeg mob los ntawm kev ua yeeb yam sai sai insulin npaj cov tsiaj keeb kwm rau insulin lispro, yuav tsum tau txhaj koob tshuaj. Kev hloov chaw ntawm cov neeg mob tau txais cov tshuaj insulin nyob rau hauv ib hnub ntau dua 100 units los ntawm ib hom tshuaj insulin mus rau lwm qhov tau pom zoo kom nqa tawm hauv tsev kho mob.

Kev xav tau rau cov tshuaj insulin tuaj yeem nce ntxiv thaum kis kab mob, nrog kev ntxhov siab hauv lub siab, nrog qhov nce ntawm cov khoom noj carbohydrates hauv cov zaub mov, thaum ntxiv kev noj tshuaj ntxiv nrog hyperglycemic kev ua si (cov thyroid hormones, glucocorticoids, qhov ncauj tiv thaiv, thiazide diuretics).

Qhov xav tau ntawm cov tshuaj insulin yuav txo qis nrog lub raum thiab / lossis lub siab ua haujlwm, nrog qhov kev txiav txim siab ntawm cov khoom noj carbohydrates hauv zaub mov, nrog kev tawm dag zog lub cev, thaum ntxiv kev noj tshuaj nrog hypoglycemic kev ua si (MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides).

Kev kho cov ntshav qog ntshav qab zib hauv qhov mob hnyav tuaj yeem nqa tawm los ntawm kev siv i / m thiab / lossis s / c tswj hwm ntawm glucagon lossis iv kev tswj xyuas ntshav qabzib.

Yeeb tshuaj sib cuam tshuam

Cov nyhuv hypoglycemic ntawm Lyspro insulin yog txhim kho los ntawm MAO inhibitors, tsis xaiv-beta-blockers, sulfonamides, acarbose, ethanol (cawv) thiab tshuaj uas muaj ethanol.

Cov nyhuv hypoglycemic ntawm Lyspro insulin yog txo los ntawm glucocorticosteroids (GCS), cov thyroid hormones, tshuaj tiv thaiv qhov ncauj, thiazide diuretics, diazoxide, tricyclic antidepressants.

Beta-blockers, clonidine, reserpine tuaj yeem npog qhov tsos ntawm cov tsos mob ntawm qog ntshav qab zib.

Cov tshuaj ntawm cov tshuaj Humalog

Cov qauv ntawm cov qauv ua haujlwm: