Yuav siv cov tshuaj Rosinsulin M li cas?
Kev rau txim rau s / c tswj hwm ntawm cov xim dawb, thaum sawv, qhov kev muab khuam daws. Cov kua dej siab dua cov nag lossis daus yog pob tshab, xim tsis muaj xim lossis yuav luag tsis muaj xim. Cov nag lossis daus tau yooj yim resuspended nrog maj mam co.
1 ml | |
insulin biphasic tib neeg kev tshawb fawb caj | 100 IU |
Tshwjxeeb: protamine sulfate 0.12-0.20 mg, sodium hydrogen phosphate dihydrate 0.26 mg, crystalline phenol 0.65 mg, metacresol 1.5 mg, glycerol (glycerin) 16 mg, dej d / thiab txog li 1 ml.
5 ml - fwj (5) - hlwv pob (aluminium / PVC) (1) - pob khoom los ntawm cardboard.
10 ml - fwj (1) - pob khoom los ntawm cardboard.
3 ml - cartridges (5) - blister sawb ntim (aluminium / PVC) (1) - pob khoom los ntawm cardboard.
Pharmacological kev txiav txim
Rosinsulin M sib xyaw 30/70 yog ib qho kev npaj nruab nrab ntawm insulin. Cov tshuaj muaj pes tsawg leeg xws li soluble insulin (30%) thiab insulin-isophan (70%). Cov tshuaj Insulin cuam tshuam nrog ib qho kev tshwj xeeb nyob rau sab nraud cytoplasmic ntawm lub hlwb thiab tsim cov txheej txheem insulin-receptor. Los ntawm kev ua kom zoo ntawm cov kab mob cAMP biosynthesis (hauv cov roj ntsha thiab lub siab ua haujlwm) lossis, nkag mus ncaj qha rau hauv lub cell (leeg), cov insulin-receptor complex txhawb cov txheej txheem intracellular, suav nrog synthesis ntawm tus lej ntawm cov enzym tseem ceeb (hexokinase, pyruvate kinase, glycogen synthase, thiab lwm yam). Txo cov ntshav qabzib yog tshwm sim los ntawm kev nce ntxiv hauv nws txoj kev thauj mus los hauv lub cev, kev nqus thiab kev pov tseg ntawm cov nqaij mos, ua kom cov lipogenesis, glycogenogenesis, synthesis protein, txo tus nqi ntawm cov piam thaj los ntawm lub siab, thiab lwm yam.
Lub sijhawm ntawm kev ua ntawm cov tshuaj insulin feem ntau yog vim tus nqi ntawm kev nqus, uas nyob ntawm ntau yam (piv txwv li, ntawm koob tshuaj, txoj kev thiab qhov chaw ntawm cov thawj coj). Yog li, cov ntaub ntawv ntawm cov insulin kev txiav txim siab yog qhov txawv txav, ob qho tib si hauv cov neeg sib txawv thiab tib neeg.
Qhov nruab nrab, tom qab kev tswj hwm sc, Rosinsulin M sib xyaw 30/70 pib ua haujlwm hauv 0.5 teev, qhov ua tau zoo tshaj plaws tau tsim kho nyob rau hauv thaj tsam li ntawm 4 txog 12 teev, lub sijhawm ua haujlwm tau ntev txog 24 teev.
Kev taw qhia ntawm cov tshuaj Rosinsulin M sib xyaw 30/70
- ntshav qab zib hom 1 rau cov neeg laus,
- hom 2 mob ntshav qab zib mellitus: theem ntawm kev tawm tsam ntawm qhov ncauj hypoglycemic, ib nrab tsis kam rau cov tshuaj no (thaum kho sib xyaw), cov kab mob sib kis.
ICD-10 code | Kev taw qhia |
E10 | Yam 1 ntshav qab zib |
E11 | Mob ntshav qab zib Hom 2 |
Kev noj tshuaj ntxiv
Rosinsulin M sib xyaw 30/70 yog npaj rau sc tswj hwm. Cov koob tshuaj ntawm cov tshuaj tau txiav txim siab los ntawm tus kws kho mob tshwj xeeb hauv txhua kis, raws li kev mloog zoo ntawm cov piam thaj hauv cov ntshav. Qhov nruab nrab, kev siv tshuaj txhua hnub los ntawm 0.5 mus rau 1 IU / kg lub cev qhov hnyav, nyob ntawm tus neeg ntawd tus yam ntxwv ntawm tus neeg mob thiab cov concentration ntawm cov piam thaj hauv cov ntshav.
Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov. Ua ntej siv, qhov kev ncua yuav tsum maj mam muab sib xyaw kom txog thaum uas zoo sib xws. Rosinsulin M sib xyaw 30/70 feem ntau yog hno sc hauv tus ncej puab. Kev hno tuaj yeem tuaj yeem ua rau hauv pem hauv ntej sab phab ntsa plab, pob tw lossis xub pwg hauv qhov projection ntawm cov nqaij deltoid.
Nws yog ib qho tsim nyog yuav tau hloov chaw txhaj tshuaj nyob rau thaj tsam anatomical kom tiv thaiv kev txhim kho ntawm lipodystrophy.
Sab sij huam
Vim muaj cov txiaj ntsig ntawm cov metabolism hauv cov metabolism: cov ntshav lub qog ua ntshav (pallor ntawm daim tawv nqaij, nce tawm hws, palpitations, tshee tshee, tshaib plab, ntxhov siab, teeb meem hauv lub qhov ncauj, mob taub hau). Kev mob ntshav qog ntshav qis tuaj yeem ua rau txhim kho kev mob hypoglycemic coma.
Kev ua xua: tsis tshua muaj - pob khaus rau ntawm daim tawv nqaij, Quincke's edema, tsis tshua muaj tshwm sim - ceeb thawj anaphylactic.
Cov tshuaj tiv thaiv hauv zos: hyperemia, o thiab khaus ntawm qhov chaw txhaj tshuaj, nrog rau siv sijhawm ntev - lipodystrophy ntawm thaj chaw txhaj tshuaj.
Lwm yam: kab mob edema, qhov hloov pauv sai sai (feem ntau thaum pib kho).
Cev xeeb tub thiab lactation
Tsis muaj kev txwv rau kev kho mob ntshav qab zib mellitus nrog cov tshuaj insulin thaum cev xeeb tub, vim hais tias cov tshuaj insulin tsis hla qhov chaw tiv thaiv. Thaum npaj kev cev xeeb tub thiab thaum nws, nws yog ib qho tsim nyog yuav tsum tau ua ntu zus ntawm kev kho mob ntshav qab zib. Qhov kev xav tau rau insulin feem ntau poob qis hauv thawj peb lub hlis thaum cev xeeb tub thiab maj mam nce ntxiv hauv qib thib ob thiab thib peb.
Thaum lub sijhawm thiab yug tom qab yug, insulin yuav tsum poob ntau. Tsis ntev tom qab yug los, xav tau cov tshuaj insulin sai sai rau qib uas yog ua ntej cev xeeb tub. Tsis muaj kev txwv rau kev kho mob ntshav qab zib mellitus nrog tshuaj insulin thaum pub niam mis. Txawm li cas los xij, nws yuav tsim nyog los txo cov koob tshuaj insulin, yog li ntawd, kev saib xyuas ceev faj rau ntau lub hlis yog qhov tsim nyog ua ntej tswj kev xav tau kom tau cov insulin.
Cov lus qhia tshwj xeeb
Ua ntej siv, ua tib zoo xyuas lub ntsej muag ntawm cov ntsiab lus ntawm lub raj mis thiab tsis txhob siv Rosinsulin M sib tov 30/70 yog tias, tom qab sib xyaw, qhov kev ncua ntawv muaj plaub ya ri lossis yog tias cov nplais dawb txuam rau hauv qab lossis phab ntsa ntawm lub raj mis, tsim cov nyhuv ntawm tus qauv khov.
Tsis txhob siv Rosinsulin M sib xyaw 30/70 yog tias, tom qab tshee, qhov kev ncua tsis dhau dawb thiab tsis tau txais huab.
Tawm tsam tom qab ntawm cov tshuaj insulin, kev tshuaj xyuas cov ntshav qabzib hauv siab yog qhov tsim nyog.
Cov laj thawj ntawm cov ntshav qog ntshav ntshav ntxiv rau kev noj tshuaj insulin ntau tshaj tuaj yeem yog: hloov tshuaj, hla zaub mov, ntuav, raws plab, kev ntxhov siab ntawm lub cev, cov kab mob uas txo qis qhov xav tau rau insulin (kev mob siab rau lub siab thiab lub raum kev ua haujlwm, kev ua haujlwm ntawm adrenal cortex, pituitary lossis thyroid caj pas), thiab hloov chaw txhaj tshuaj, thiab kuj cuam tshuam nrog lwm cov tshuaj.
Kev noj tshuaj tsis yog lossis cuam tshuam rau hauv cov tshuaj insulin, tshwj xeeb tshaj yog nyob rau cov neeg mob ntshav qab zib hom 1, tuaj yeem ua rau mob hyperglycemia. Feem ntau, thawj cov tsos mob ntawm hyperglycemia pib maj mam dhau ob peb teev lossis hnub. Cov no suav nrog kev nqhis dej, ntxiv tso zis, xeev ntuav, ntuav, kiv taub hau, liab thiab ntawm daim tawv nqaij, qhov ncauj qhuav, tsis qab los, tsis hnov ntxhiab ntawm cov acetone hauv cov pa tawm. Yog tias tsis kho, hyperglycemia hauv ntshav qab zib hom 1 tuaj yeem ua rau muaj kev tiv thaiv cov mob ntshav qab zib ketoacidosis. Cov koob tshuaj insulin yuav tsum raug kho rau kev ua haujlwm ntawm cov thyroid tsis zoo, Addison's disease, hypopituitarism, ua rau lub siab thiab lub raum tsis ua haujlwm, thiab ntshav qab zib mellitus rau cov neeg uas muaj hnub nyoog 65 xyoos.
Kev kho tshuaj ntawm cov tshuaj insulin kuj tseem xav tau yog tias tus neeg mob nce qib qoj ib ce lossis hloov cov zaub mov ib txwm muaj.
Cov kab mob sib xyaw tshwj xeeb, tshwj xeeb tshaj yog kis mob thiab cov kab mob nrog kub taub hau, nce ntxiv qhov xav tau ntawm insulin.
Kev hloov koob thiab hloov los ntawm ib hom tshuaj insulin mus rau lwm qhov yuav tsum tau ua nyob rau hauv kev saib xyuas ntawm tus kws kho mob thiab saib xyuas cov concentration ntawm cov piam thaj hauv cov ntshav. Cov tshuaj txo qis cawv rau cov neeg haus cawv.
Vim tias muaj qhov ua rau nag lossis daus hauv qee qhov ntsuas, kev siv yeeb tshuaj hauv cov tshuaj insulin tsis pom zoo.
Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab
Hauv kev sib txuas nrog lub hom phiaj tseem ceeb ntawm insulin, kev hloov pauv ntawm nws hom lossis nyob ntawm qhov tseem ceeb ntawm lub cev lossis lub hlwb kev ntxhov siab, nws muaj peev xwm txo qis kev muaj peev xwm tsav lub tsheb lossis tswj ntau cov txheej txheem, nrog rau koom nrog rau lwm yam dej num txaus ntshai uas xav tau nce siab thiab ceev ntawm lub hlwb thiab lub cev kev xav.
Noj ntau dhau
Cov tsos mob: nrog ib tug noj ntau dhau, mob ntshav qab zib yuav tshwm sim.
Kev Kho Mob: tus neeg mob tuaj yeem tshem tawm qhov tsis muaj ntshav qab zib tsawg los ntawm kev noj cov piam thaj lossis zaub mov carbohydrate. Yog li, nws tau pom zoo rau cov neeg mob ntshav qab zib kom nqa cov piam thaj, qab zib, ncuav qab zib lossis kua txiv qab zib nrog lawv. Hauv cov xwm txheej loj, thaum tus neeg mob poob siab, ib qho 40% kev daws yog siv iv
dextrose (piam thaj), hauv / m, s / c, hauv / hauv - glucagon. Tom qab nws rov qab nco qab, tus neeg mob tau pom zoo kom noj cov khoom noj uas muaj cov khoom noj carbohydrate kom tiv thaiv kev rov qab txhim kho hypoglycemia.
Yeeb tshuaj sib cuam tshuam
Muaj ntau tus lej ntawm cov tshuaj uas cuam tshuam rau kev xav tau cov tshuaj insulin. Hypoglycemic nyhuv ntawm insulin txhim khu qhov ncauj hypoglycemic tshuaj, Mao inhibitors, ACE inhibitors, carbonic anhydrase inhibitors, xim beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic steroids, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, lithium npaj npaj muaj ethanol.
Hypoglycemic nyhuv ntawm insulin lus qhov ncauj contraceptives, corticosteroids, thyroid hormone, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, calcium channel blockers qeeb, diazoxide, morphine, phenytoin, nicotine, sulfinpyrazone, epinephrine, histamine H 1 receptor.
Nyob rau hauv kev cuam tshuam ntawm reserpine thiab salicylates, ob qho tib si ua kom tsis muaj zog thiab nce ntxiv hauv kev ua ntawm cov tshuaj muaj peev xwm ua tau.
Yuav siv li cas: noj ntau thiab hom tshuaj kho
Cov tshuaj yog npaj rau subcutaneous thawj coj. Cov koob tshuaj ntawm cov tshuaj tau txiav txim siab los ntawm tus kws kho mob tshwj xeeb hauv txhua kis, raws li kev mloog zoo ntawm cov piam thaj hauv cov ntshav. Qhov nruab nrab, kev siv tshuaj txhua hnub los ntawm 0.3 mus txog 1 IU / kg lub cev qhov hnyav, nyob ntawm tus neeg qhov yam ntxwv ntawm tus neeg mob thiab cov ntsiab lus ntawm cov piam thaj hauv cov ntshav.
Kev xav tau txhua hnub rau insulin tuaj yeem siab dua nyob rau hauv cov neeg mob uas muaj insulin tsis kam (piv txwv li, thaum pub, nrog rau cov neeg mob rog rog), thiab qis dua rau cov neeg mob uas muaj cov insulin endogenous ntau lawm.
Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov. Ua ntej siv, qhov kev ncua yuav tsum maj mam muab sib xyaw kom txog thaum uas zoo sib xws. Cov tshuaj feem ntau yog muab tshuaj subcutaneously hauv tus ncej puab. Kev hno tuaj yeem ua tau nyob hauv thaj av ntawm lub plab mog sab xub ntiag, lub pob tw los yog hauv thaj av ntawm deltoid leeg ntawm lub xub pwg. Nrog kev qhia txog cov tshuaj rau hauv tus ncej puab, muaj qhov nqus qis dua li thaum qhia mus rau lwm thaj chaw.
Nws yog ib qho tsim nyog los hloov qhov chaw txhaj tshuaj tsis pub dhau thaj chaw anatomical kom tiv thaiv kev txhim kho ntawm lipodystrophy.
Thaum siv cov koob txhaj tshuaj ua ntej uas muaj ntau cov koob txhaj tshuaj kom tau txais kev txhaj tshuaj dua, nws yog qhov yuav tsum tau tshem tawm cov kua xaum xoos tawm hauv lub tub yees ua ntej siv thiab cia cov tshuaj mus txog chav sov. Nws yog ib qho tsim nyog los sib tov qhov kev ncua ntawm ROSINSULIN M sib tov 30/70 hauv cov xaum xoob pov tseg tam sim ua ntej siv. Qhov kev ncua zoo muab tshem tawm yuav tsum hnav uniformly dawb thiab pos huab. Cov tshuaj hauv tus cwj mem uas siv tag pov tseg tsis tuaj yeem siv yog tias nws tau khov. Nws yog qhov tseem ceeb uas koj ua raws li cov lus qhia rau kev siv koob txhaj tshuaj muab nkag nrog cov tshuaj.
Cov kab mob tsis haum, tshwj xeeb tshaj yog kis thiab nrog kub taub hau, feem ntau ua rau lub cev xav tau cov tshuaj insulin. Koob tshuaj kuj tseem yuav tsum tau ua yog tias tus neeg mob tau muaj cov kab mob ntawm lub raum, mob siab, ua haujlwm tsis zoo hauv lub qog, lub caj pas pituitary lossis lub qog ua haujlwm.
Qhov xav tau kom haum rau kev txhaj tshuaj kuj tuaj yeem tshwm sim thaum hloov lub cev lossis cov neeg mob ib txwm noj. Koob tshuaj yuav tau tuaj yeem hloov kho thaum hloov tus neeg mob los ntawm ib hom tshuaj insulin mus rau lwm tus.
Sab sij huam
Feem ntau cov kev tshwm sim tsis zoo nrog cov tshuaj insulin yog hypoglycemia. Hauv kev sim tshuaj, nrog rau thaum lub sijhawm siv cov tshuaj tom qab nws tso tawm ntawm cov neeg siv khoom lag luam, nws tau pom tias qhov xwm txheej ntawm cov ntshav qog ntshav qis sib txawv raws li cov neeg mob, qhov ntau npaum li cas ntawm cov tshuaj, thiab kev tswj glycemic.
Thaum pib ntawm kev siv tshuaj insulin, qhov rov ua kom yuam kev, qhov tawm ntawm lub qhov txhab thiab cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj (suav nrog qhov mob, liab, urticaria, mob o, hematoma, o thiab khaus ntawm qhov chaw txhaj tshuaj) yuav tshwm sim. Cov tsos mob no feem ntau yog ib ntus. Kev txhim kho sai ntawm glycemic tswj tuaj yeem ua rau lub xeev ntawm 'mob mob neuropathy', uas feem ntau thim rov qab. Kev siv tshuaj insulin ntau dua nrog kev txhim kho ntse hauv kev tswj hwm ntawm cov metabolism hauv cov roj ntsha tuaj yeem ua rau muaj kev tsis txaus siab nyob rau hauv cov xwm txheej ntawm tus mob ntshav qab zib retinopathy, thaum lub sij hawm ntev txhim kho hauv glycemic tswj txo qhov kev pheej hmoo ntawm kev mob ntshav qab zib retinopathy.
Tso cov ntaub ntawv thiab cov nyob ua ke
Ib qho kev ncua rau kev saib xyuas ntawm 100 IU / ml yog muaj nyob rau hauv daim ntawv ntawm:
- lub raj mis ntawm 5 thiab 10 ml,
- 3 ml cartridge.
1 ml ntawm cov tshuaj muaj:
- Cov khoom siv tseem ceeb yog tib neeg cov noob caj noob ces insulin 100 IU.
- Lub Cheebtsam pabcuam: protamine sulfate (0.12 mg), glycerin (16 mg), dej rau kev txhaj tshuaj (1 ml), metacresol (1.5 mg), crystalline phenol (0.65 mg), sodium hydrogen phosphate dihydrate (0.25 mg).
Kev ncua rau kev saib xyuas ntawm 100 IU / ml muaj nyob rau hauv daim ntawv ntawm: lub raj mis ntawm 5 thiab 10 ml, cartridge ntawm 3 ml.
Cov Tshuaj Pharmacokinetics
Ua tiav kev nqus thiab qhov tshwm sim ntawm cov nyhuv nyob ntawm seb qhov ntau npaum li cas, txoj kev thiab qhov chaw ntawm kev txhaj tshuaj, cov tshuaj insulin. Cov tshuaj yog rhuav tshem los ntawm kev ua ntawm insulinase hauv ob lub raum. Nws pib ua yeeb yam ib nrab ib teev tom qab kev tswj hwm, nce mus txog lub ncov ntawm 3-10 teev hauv lub cev, nres ua yeeb yam tom qab 1 hnub.
Daim ntawv, qauv thiab kev ua haujlwm ntawm kev ua haujlwm
"Rosinsulin" yog hais txog cov tshuaj ntawm cov "hypoglycemic agents". Nyob ntawm qhov ceev thiab ntev ntawm kev nqis tes ua, muaj:
Qab zib yog txo tam sim ntawd! Mob ntshav qab zib ntev mus ntev tuaj yeem ua rau tag nrho cov kab mob, xws li teeb meem tsis pom kev, tawv nqaij thiab plaub hau, mob rau sab hauv, mob caj pas thiab mob qog nqaij hlav! Cov neeg qhia kev iab kev xav mus li qub rau lawv qab zib. nyeem rau.
- "Rosinsulin S" nrog rau lub caij nyoog nruab nrab ntawm kev nqis tes ua,
- "Rosinsulin R" - nrog luv,
- "Rosinsulin M" yog tus sawv cev sib xyaw ua ke uas muaj 30% solulin insulin thiab 70% insulin-isophan.
Ib qho tshuaj yog cov tshuaj insulin tau los ntawm tib neeg lub cev los ntawm kev hloov DNA. Cov lus qhia tau qhia tias lub hauv paus ntsiab lus ntawm kev nqis tes yog los ntawm kev sib cuam tshuam ntawm qhov tseem ceeb ntawm cov tshuaj muaj hlwb thiab kev tsim cov tshuaj insulin tom qab. Yog li ntawd, cov synthesis ntawm cov enzymes uas tsim nyog rau kev ua haujlwm ntawm lub cev tau tshwm sim. Kev siv suab thaj ntau dhau vim tshwm sim vim cov tshuaj metabolism hauv lub cev thiab kev nqus txaus. Raws li cov kws tshaj lij, cov txiaj ntsig ntawm daim ntawv thov raug pom li 1-2 teev tom qab coj hauv qab daim tawv.
"Rosinsulin" yog kev ncua rau kev tswj hwm hauv qab daim tawv nqaij. Qhov kev txiav txim yog vim yog cov ntsiab lus ntawm insulin-isophan.
Sab nraud, cov tshuaj yog dawb nrog pob me ntsis gint. Thaum tsis muaj kev co, nws tau muab cais ua kua dej thiab nag lossis daus sai. Raws li cov lus qhia, "Rosinsulin" yuav tsum tau muab co ua ntej ua haujlwm. Tsis tas li ntawd, cov tshuaj muaj pes tsawg leeg suav nrog cov tshuaj piav qhia hauv lub rooj: