9 muaj txiaj ntsig zoo thiab tsis muaj txiaj ntsig zoo ntawm Rosuvastatin

Analogues ntawm cov tshuaj Krestor raug nthuav tawm, raws li cov lus kho mob, hu ua "txhais ua" - cov tshuaj sib hloov uas muaj ib lossis ntau ntawm tib cov tshuaj yeeb dej caw nyob rau hauv cov nqe lus ntawm lawv cov cuam tshuam rau lub cev. Thaum xaiv cov lus txhais, xav txog tsis yog lawv cov nqi nkaus xwb, tab sis kuj yog lub teb chaws ntawm kev tsim khoom thiab lub koob npe ntawm cov neeg tsim khoom.

Qhia txog ntawm cov tshuaj

Rosuvastatin yog qhov xaiv, kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl coenzyme A rau mevalonic acid, cov roj ua ntej. Lub hom phiaj tseem ceeb ntawm kev ua ntawm rosuvastatin yog lub siab, qhov twg cov synthesis ntawm cov roj (cov cholesterol) thiab catabolism ntawm lipoproteins tsawg ntom (LDL) yog nqa tawm.

Rosuvastatin nce tus naj npawb ntawm "daim siab" LDL receptors rau ntawm lub ntsej muag ntawm tes, nce kev nce siab thiab catabolism ntawm LDL, uas ua rau cov inhibition ntawm cov hluavtaws lipoproteins tsawg heev (VLDL), yog li txo tag nrho cov nyiaj ntawm LDL thiab VLDL.

Krestor ers txo qis kom nce ntau ntawm LDL cov cholesterol (cov roj cholesterol-LDL), cov roj (cholesterol) tag nrho, triglycerides (TG), cov tshuaj lipoprotein ntau dua cov roj lipoprotein (HDL-C), thiab txo qis cov tshuaj apolipoprotein B (ApoV), cov roj uas tsis yog HDL, -LVONP, TG-VLDLP thiab nce siab ntawm apolipoprotein AI (ApoA-I) (saib cov lus 1 thiab 2), txo qhov feem ntawm LDL-C / HDL-HDL, tag nrho cov roj cholesterol / HDL-C thiab HDL-C / HDL-C thiab ApoB / ApoA-1 piv.

Kev ua rau txoj kev kho kom zoo dua qub hauv ib lub lis piam tom qab pib kho nrog Krestor ®, tom qab 2 lub lis piam ntawm kev kho mob nce mus txog 90% ntawm cov txiaj ntsig siab tshaj plaws. Kev kho mob siab tshaj plaws feem ntau ua tiav los ntawm 4 lub lim tiam ntawm kev kho thiab tswj nrog kev siv cov tshuaj tsis tu ncua.

Rooj 1 thiab 1a.Koob-nyob nyhuv nyob rau hauv cov neeg mob nrog thawj hypercholesterolemia (hom IIa thiab IIb raws li Fredrickson) (qhov hloov qhov nruab nrab feem ntau hloov piv rau tus nqi qub).

Krestor effective ua tau zoo rau cov neeg mob cov neeg laus uas muaj hypercholesterolemia nrog lossis tsis muaj hypertriglyceridemia, tsis hais haiv neeg twg, poj niam lossis txiv neej, suav nrog. hauv cov neeg mob ntshav qab zib mellitus thiab tsev neeg hypercholesterolemia.

Hauv 80% ntawm cov neeg mob uas muaj hom IIa thiab IIb hypercholesterolemia raws li Fredrickson (qhov pib nruab nrab ntawm LDL cov cholesterol yog kwv yees li 4.8 mmol / L) thaum noj cov tshuaj ntawm 10 mg, qhov siab ntawm LDL cov roj cholesterol mus txog tus nqi tsawg dua 3 mmol / L.

Hauv cov neeg mob hypertriglyceridemia nrog kev pib ntawm TG los ntawm 273 txog 817 mg / dl uas tau txais Krestor ® hauv ib koob ntawm 5 mg rau 40 mg ib zaug ib hnub rau 6 lub lis piam, qhov concentration ntawm TG hauv cov ntshav ntshav tau txo qis (saib cov lus 2).

Ib qho kev tiv thaiv ntxiv tau pom nyob rau hauv kev sib xyaw nrog fenofibrate hauv kev sib piv rau cov concentration ntawm triglycerides thiab nrog nicotinic acid nyob rau hauv lipid txo cov koob tshuaj hauv qhov kev piv rau cov concentration ntawm HDL-C.

Hauv txoj kev tshawb nrhiav METEOR, koom nrog 984 cov neeg mob hnub nyoog 45-70 xyoo muaj qhov pheej hmoo tsawg los txhim kho cov hlab plawv (10-xyoo kev pheej hmoo ntawm daim Framingham nplai qis dua 10%), qhov nruab nrab ntawm cov ntshav LDL cov roj cholesterol ntawm 4.0 mmol / l (154.5 mg / dl) thiab subclinical atherosclerosis ( uas tau txheeb xyuas los ntawm cov tuab ntawm intima-media complex ntawm cov carotid hlab ntsha - TCIM) qhov cuam tshuam ntawm rosuvastatin ntawm tuab ntawm intima-media complex tau kawm. Cov neeg mob tau txais rosuvastatin ntawm ib koob ntawm 40 mg / hnub lossis placebo rau 2 xyoos.Rosuvastatin txoj kev kho mob maj mam ua tiav qhov kev nce qib ntawm qhov siab tshaj plaws TCIM rau 12 ntu ntawm cov carotid leeg o piv nrog cov placebo nrog qhov sib txawv ntawm -0.0145 hli / xyoo. Muab piv nrog cov nqi pib hauv rosuvastatin pawg, qhov txo qis ntawm tus nqi siab tshaj plaws ntawm TCIM los ntawm 0.0014 hli / xyoo (0.12% / xyoo (tsis tseem ceeb sib txawv)) tau sau tseg piv nrog qhov nce ntawm qhov ntsuas no los ntawm 0.0131 hli / xyoo (1.12% / xyoo (p 1/100 , 1/1000, 1/10000, Cov Lus Sib Xws

Feem ntau, kev mob nkeeg dhau ib tus neeg thaum nws tsis npaj siab mus ntsib lawv. Kev kis tus kab mob yog cov kev mob tshwm sim tshaj plaws hauv lub ntiaj teb niaj hnub no. Nrog rau lawv, cov kab mob feem ntau tshwm sim uas cuam tshuam cov hlab ntsws. Ntawm.

Cov tshuaj ntsuab tau cawm tib neeg thaum lub sijhawm kaj ntug. Cov zaub mov txawv ntuj rau cov neeg niaj hnub tsis tau poob lawv qhov tseeb. Kev kho mob ntawm ulcerative colitis nrog tshuaj ntsuab muaj kev sib txawv hauv kev sib txuam. Kev lom roj.

Lub ntswg los ntswg hauv miv tuaj yeem tshwm sim los ntawm ntau yam. Feem ntau, cov ntswg tawm hauv cov tsiaj tshwm vim yog tus mob khaub thuas. Qee zaum cov mob rhinitis yog qhov tshwm sim los ntawm kev ua xua lossis qee tus mob kis tau hnyav.

Ntsiav tshuaj Cheebtsam

Cov tshuaj phiv tshuaj ntawm cov tshuaj yog calcium ntsev ntawm rosuvastatin. Ntxiv rau, cov muaj pes tsawg leeg suav nrog ntau qhov ntawm cov khoom siv ntxiv, uas lawv tau ua lub luag haujlwm:

1. Microcrystalline cellulose yog adsorbent zoo, uas yog excreted tsis hloov pauv ntawm tib neeg lub cev. Hauv tshuaj muaj pes tsawg leeg, nws ua haujlwm uas muab tub lim thiab cov tshuaj uas ua hauj lwm rau txhua qhov sib xyaw.
2. Lactose Monohydrate. Siv los txhim kho qhov saj ntawm cov tshuaj. Txawm li cas los xij, cov tshuaj no ua rau nws tsis tuaj yeem noj cov ntsiav tshuaj rau cov tib neeg kev txom nyem los ntawm kev tsis txaus siab lossis lactase tsis txaus.
3. Tshuaj Calcium Phosphate Qhov no yog cov khoom sib txuam, uas suav nrog cov xim hlau thiab calcium phosphoric acid. Cov tshuaj tiv thaiv hauv cov ntsiav tshuaj pab kom cov kab mob sib xyaw ua ke.
4. Magnesium stearate. Facilitates txheej txheem ntsiav tshuaj thiab ua haujlwm uas muab tub lim muaj kev nyab xeeb rau lub cev.
5. Hydroxypropyl methylcellulose yog cov tshuaj pleev ib ce tshwj xeeb uas yog qhov tseem ceeb rau kev tsim cov txheej txheem ntawm daim ntawv ntau npaum.
6. Povidone ua ib yam dab tsi uas ua kom cov tshuaj lom tsis zoo rau lub cev, nrog rau cov uas tau tsim los ntawm kev ua ntawm rosuvastatin.
7. Triacetin yog kev pom zoo ntxiv khoom noj (E1518). Raws li ib feem ntawm cov ntsiav tshuaj, nws ua raws li cov yas yas thiab cov tshuaj noo noo, uas yog qhov tseem ceeb rau cov txheej txheem.
8. Dyes - hlau oxide thiab titanium dioxide muaj kev nyab xeeb ntxiv txhawm rau txhim kho cov tsos ntawm cov tshuaj.

Rosuvatatin ntsiav tshuaj siv rau cov roj (cholesterol) siab dua tus txheej txheem yog tsim los ntawm ntau lub tuam txhab kws kho mob nyob hauv ntau lub npe. Tag nrho ntawm lawv yog cov ncaj qha analogues, uas yog, lawv muaj tib yam khoom muaj nqis.

Tus thawj cov tshuaj Krestor yog tsim los ntawm lub tuam txhab Askiv thiab muaj lub koob npe nrov ua cov tshuaj zoo tshaj plaws. Txhua lwm yam tshuaj nyob qhov twg cov tshuaj ua kom nquag plias yog rosuvastatin yog cov tshuaj ntxuav tawm.

Lawv txawv ntawm cov thawj hauv cov nqi thiab yuav muaj qhov sib txawv me ntsis ntawm cov koomhaum pabcuam, uas tsis cuam tshuam rau lawv cov haujlwm. Qhov point no yuav tsum tau coj mus rau hauv tus account nrog nce rhiab heev rau qee yam tshuaj.

Pharmacological kev txiav txim

Ib qho tshuaj tiv thaiv hypolipidemic yog kev xaiv, kev sib tw inhibitor ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy-3-methylglutaryl coenzyme A rau mevalonate, ib qho ua ntej ntawm cov roj (Xc). Lub hom phiaj tseem ceeb ntawm kev ua ntawm rosuvastatin yog lub siab, qhov twg Xc synthesis thiab LDL catabolism yog nqa tawm.

Kev kho mob nyhuv tshwm nyob rau hauv 1 lub lis piam tom qab pib kho mob Krestor, tom qab 2 lub lis piam ntawm kev kho mob nce mus txog 90% ntawm cov txiaj ntsig siab tshaj plaws. Kev kho mob siab tshaj plaws feem ntau ua tiav los ntawm 4 lub lis piam thiab tswj nrog kev siv tas li.

Txog li 90% ntawm koob tshuaj rosuvastatin yog pom tsis hloov pauv nrog quav. Cov seem yog tawm hauv zis.

Analogues ntawm cov tshuaj

Cov lus piv txwv yog pheej yig dua li qhov qub, thiab tus neeg mob tuaj yeem hloov nws ib qho tshuaj nrog lwm qhov, tsom mus rau qhov uas yuav them taus los sis muaj cov tshuaj hauv lub tsev muag tshuaj. Lawv txawv qee qhov hauv kev ua haujlwm, uas cuam tshuam nrog cov khoom zoo uas siv thiab qee qhov sib txawv hauv cov txheej txheem. Cov qauv tshuaj uas cov tshuaj nquag yog rosuvastatin:

1. Neeg Coob. Thawj cov tshuaj ua nyob rau hauv UK. Nws muaj bioavailability siab, muaj kev kho mob nrawm nrog cov roj ntshav siab dua li ib txwm. Nws muaj tus nqi siab dua nyob rau hauv kev sib piv nrog generics.
2. Akorta, Rosuvastatin Canon thiab Rosuvastatin SZ tsim kev lag luam hauv Lavxias. Lawv zwm rau qeb ntawm cov pheej yig. Tab sis lawv muaj qis dua bioavailability, ntau maj mam tsim lub siab nyob rau hauv lub cev tsim nyog kom ua tiav cov nyhuv siab. Nws yog sai tawm ntawm lub cev.
3. Mertenil. Chaw tsim tshuaj paus - Hungary. Nws kuj tseem muaj cov neeg qis qis dua, yog li cov txiaj ntsig kho tshwm sim tom qab dhau los ntawm cov tshuaj qub.
4. Rosulip yog lwm qhov tshuaj los ntawm cov neeg tsim khoom hauv Hungarian. Nws tsis muaj nqi heev. Nws yog qhov txawv txav los ntawm kev ua haujlwm siab, tab sis tib lub sijhawm, nws maj mam khaws cia, tsim cov kev xav kho kom zoo.
5. Rosart yog tsim los ntawm lub tuam txhab Icelandic. Nws muaj txhua qhov zoo ntawm cov tshuaj qub, nws qhov tsis zoo suav nrog nws cov nqi siab.
6. Rosistark. Ntau Lawm Croatia. Nws tsis yog qis dua rau Rosart lossis Krestor hauv ib txoj kev twg, tib lub sijhawm nws tseem muaj tus nqi theej siab.
7. Tevastor Nws yog tsim los ntawm lub tuam txhab Israeli chaw tsim tshuaj, ceev hauv lub cev sai sai thiab muaj cov tshuaj ua kom zoo. Muaj tus nqi siab.
8. Roxer yog tsim los ntawm lub tuam txhab Slovenian paub zoo. Nws muaj tus nqi nruab nrab, zoo bioavailability, tab sis yog sai sai tawm ntawm lub cev thiab yog li ntawd maj mam muaj cov nyhuv kho.
9. Rosucard yog Czech txoj kev npaj. Ntawm tus nqi nruab nrab, nws muaj bioavailability siab, tab sis tus nqi qes ntawm kev pib ntawm kev kho kho mob.

Txhua yam tshuaj no yog cov tshuaj ncaj qha, piv txwv li, nrog ib yam tshuaj thiab muaj qhov tsis zoo. Hauv kev xyaum, lawv yog ib qho thiab tib qho cuab yeej, uas muaj cov npe sib txawv thiab raug muag hauv tus nqi sib txawv. Muaj cov indirect analogues.

Cov tshuaj no muaj cov txiaj ntsig ib qho (hauv qhov no, lipid-txo qis), tab sis lawv muaj cov khoom siv sib txawv. Hloov chaw rau cov analogues no tsuas yog ua tau los ntawm tus kws kho mob.

Pharmacokinetics hauv cov chaw kuaj mob tshwj xeeb

Tus poj niam txiv neej thiab lub hnub nyoog tsis muaj kev xav paub ntau ntxiv hauv lub chaw muag tshuaj ntawm rosuvastatin.

Hauv cov neeg mob uas mob mentsis mus rau lub raum tsis ua haujlwm, lub plasma ntshav ntawm rosuvastatin lossis N-dysmethyl tsis hloov pauv ntau.

Hauv cov neeg mob uas mob raum tsis zoo (CC 1/100, 1/1000, 1/10 000,

9 muaj txiaj ntsig zoo thiab tsis muaj txiaj ntsig zoo ntawm Rosuvastatin

• Ntsiav tshuaj Cheebtsam
• Analogues ntawm cov tshuaj

Rosuvastatin thiab nws cov tshuaj noj tau txhawm rau muab cov roj (cholesterol) hauv cov ntshav siab tshaj qhov qub. Cov tshuaj yog zwm rau cov chav kawm ntawm statins ntawm lub xeem (4 tiam). Piv nrog rau lwm cov tshuaj nyob rau hauv pab pawg no, rosuvastatin yog ib txoj kev ua tau zoo dua thiab muaj kev nyab xeeb.

Nws tau tsim synthetically thiab qhia txog cov khoom hauv hydrophilic, qhov txiaj ntsig ntawm qhov nws tsis muaj suab nrov hais txog lub siab.

Cov tshuaj ua tau zoo tsim kev tiv thaiv cov tshuaj lipoproteins uas tsis muaj ntau, uas ua cov tshuaj tseem ceeb uas cov roj (cholesterol) yog tsim los.

Ntxiv rau, kev noj cov tshuaj no tsis ua rau mob nqaij pob txha thiab lwm yam kab mob pathologies los ntawm sab ntawm cov leeg nqaij. Qhov tsim nyog cov nyhuv yog manifested twb ib lub lim tiam tom qab pib ntawm kev siv, thiab los ntawm 4 lub lis piam nws ua lub siab tshaj plaws thiab nrog kev kho mob tsis tu ncua kav ntev heev. Cov kev zoo no ua rau rosuvastatin ua ib lub siab xav tau cov tshuaj rau cov neeg mob uas xav tau qis roj.

Crestor: cov lus qhia rau kev siv, analogues, cov nqi thiab tshuaj xyuas

1. Cov lus sib xyaw thiab cov ntawv ntau npaum
2. Pharmacological tau
3. Cov Tshuaj Hauv Tshuaj
4. Cov Tshuaj Pharmacokinetics
5. Leej twg yog Crestor qhia
6. Yuav thov li cas
7. Sab sij huam
8. Ntawv thov kev txwv
9. Sib xyaw nrog lwm yam tshuaj
10. Crestor: analogues
11. Dab tsi ua kws kho mob thiab cov neeg mob xav txog Crestor

Peb cov neeg nyeem tau siv Aterol ua tiav kom qis cov roj (cholesterol). Pom qhov nrov ntawm cov khoom no, peb tau txiav txim siab muab nws rau koj kom txaus siab.

Koj tuaj yeem xav zoo nyob hauv koj lub neej tsis xws luag, thiab tom qab soj ntsuam, kawm txog hyperlipidemia - cov ntsiab lus ntawm cov roj cholesterol thiab triglycerides hauv cov ntshav. Kev mob asymptomatic ua rau muaj kev pheej hmoo loj ntawm cov quav txaij atherosclerotic plaques - cov kev xav ua ntej ntawm kev mob plawv thiab mob nkees.

Krestor, ib qho tshuaj zoo ntawm cov cim tshiab, tsim los ua kom cov lipid metabolism zoo li qub, yuav pab tiv thaiv kev phom sij.

Cov lus sib xyaw thiab cov ntawv ntau npaum

Tus ntoo khaub lig tau muag nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Nyob ntawm seb cov tshuaj siv los ntawm cov tshuaj nquag, ntau hom tshuaj yog tsim:

1. Cov cim hauv daj thiab sau nrog ZD4522 5 yog convex, puag ncig, muaj 5 g ntawm rosuvastatin.
2. Crestor paj yeeb cov xim zoo li cov duab sib luag nrog ZD4522 10 muaj 10 mg ntawm cov tshuaj nquag.
3. Hauv tib hom ntsiav tshuaj nrog inscription ZD4522 20 - rosuvastatin 20g.
4. Qhov siab tshaj plaws ntawm cov tshuaj nquag (49 mg) yog hauv cov qe liab cov ntsiav tshuaj nrog cov cim ZD4522.

Txhua hom tshuaj noj (suav nrog tshuaj analogues) yog nruj tshuaj

Cov Tshuaj Hauv Tshuaj

Krestor inhibits HMG-CoA reductase, ib qho enzyme uas tswj kev tsim cov mevalonate, cov roj cholesterol ua ntej. Rosuvastatin ua haujlwm nyob rau hauv daim siab - ib qho ntawm lub ntsiab hom kabmob.

Statin txo cov lipoproteins ntau nrog qhov tsawg thiab tsis tshua muaj siab los ntawm kev txwv lawv cov synthesis, ntxiv rau txhim kho HDL ntxiv rau kom sib luag thiab catabolism ntawm LDL. Raws li qhov tshwm sim, qib ntawm cov roj (cholesterol) tag nrho, LDL thiab triglycerides tsawg dua. Nyob rau tib lub sijhawm, qhov concentration ntawm HDL nce.

Rosuvastatin ua tau zoo rau hypercholesterolemia hauv kev sib xyaw nrog lossis tsis muaj hypertriglyceridemia, rau cov neeg mob ntawm pojniam lossis pojniam, hnub nyoog thiab haiv neeg.

Cov txiaj ntsig ntawm kev siv Krestor, kev txiav txim siab los ntawm cov lus tawm tswv yim los ntawm cov neeg koom nrog kev tshawb fawb, raug pom los ntawm qhov kawg ntawm thawj lub lim tiam ntawm qhov kev kawm, tab sis qhov tshwm sim siab tshaj (dhau 90%) tuaj yeem pom tsuas yog tom qab 2-4 lub lim tiam ntawm kev siv tas li.

Tsis zoo li qee qhov analogues, Krestor muaj qhov tsawg kawg ntawm qhov tsis zoo ntawm daim siab. Siv nws ua ke nrog kev noj zaub mov roj kom tsawg thiab lwm yam tshuaj noj kom txo cov roj cholesterol.

Leej twg yog Crestor qhia

Thaum hloov Krestor nrog analogues, nws yog ib qho tsim nyog kom paub meej raws li cov xwm txheej lawv siv.

Thawj cov tshuaj qhia:

• Nrog hypercholesterolemia (thawj hom ntawv lossis tsev neeg homozygous),
• Rau kev tiv thaiv mob stroke,
• Nrog rau kev sib xyaw hypercholesterolemia,
• Rau kev tiv thaiv ntawm lub plawv nres,
• Cov neeg mob atherosclerosis,
• Nrog hypertriglyceridemia.

Yuav thov li cas

Txoj kev kho mob thiab kev noj tshuaj yog tsim los ntawm tus kws kho mob raws li kev soj ntsuam, lub xeev kev noj qab haus huv, kab mob concomitant.

Cov kev cai dav dav rau kev siv Crestor:

• Cov ntsiav tshuaj tsis tas yuav tsum zuaj.
• Lub sijhawm txais tos - txhua qhov yooj yim, cov txiaj ntsig siab tshaj plaws tuaj yeem tau txais los ntawm kev siv thaum yav tsaus ntuj, vim tias feem ntau cov roj cholesterol yog tsim thaum hmo ntuj.
• Noj mov tsis cuam tshuam rau qhov ua tau zoo ntawm kev noj tshuaj.
• Ua ntej pib ntawm chav kawm, tus neeg mob yuav tsum hloov mus rau kev noj zaub mov kom tsis txhob rog, uas yuav tsum tau saib xyuas tas li.
• Thawj koob tshuaj Crestor (5-10g / hnub) tau xaiv ib tus zuj zus. Yog tias cov txiaj ntsig tsis tau raws li kev cia siab, koj tuaj yeem hloov kho qhov koob tshuaj rau 20 mg / hnub., Tab sis tsis ntxov dua ib hlis tom qab. Qhov siab tshaj plaws qhov siab tshaj plaws (40 mg / hnub) yog tsuas yog muaj kev pheej hmoo siab ntawm kev mob vascular thiab lub plawv dhia tsis zoo. Ib tus neeg mob uas muaj mob hypercholesterolemia yuav tsum muaj kev saib xyuas hauv tsev kho mob tas mus li, vim tias qhov feem ntau ntawm cov kev mob tshwm sim yuav loj tuaj. Kev soj ntsuam ntawm lipid profile cov ntaub ntawv txhawm rau txhim kho cov chav kawm ntawm txoj kev kho yuav tsum tau ua txhua 2-4 lub lis piam.

Yog tias dhau ntawm kev siv ntau dhau, ib qho tshuaj tiv thaiv tshwj xeeb tsis siv. Txoj kev kho yog mob tshwm sim, coj mus rau hauv qhov nruab nrab ntawm kev lom. Yog tias tsim nyog, nqis tes pab txhawb.

Sab sij huam

Nrog kev soj ntsuam nruj ntawm cov lus pom zoo los ntawm tus kws kho mob koom, cov neeg mob tsis tshua yws txog qhov yuav tshwm sim tsis txaus ntseeg los ntawm kev siv Krestor. Thiab tseem, cov lus qhia rau kev siv ceeb toom ntawm qhov yuav ua rau tsis muaj qhov tsis haum. Cov ntaub ntawv yog raws cov kev tshawb fawb soj ntsuam.

Tag nrho cov tshuaj saum toj no yog qhov ncaj qha ntawm rosuvastatin, uas yog, tshuaj nrog cov tshuaj muaj zog zoo ib yam. Qhov tseeb, qhov no yog txhua yam - tib cov yeeb tshuaj nrog cov lag luam txawv npe thiab muag ntawm tus nqi muag khoom txawv thiab muag khoom (tus nqi nruab nrab yuav muab rau hauv lub rooj hauv ntu txuas ntxiv ntawm kev tshaj tawm). Tseem muaj cov piv txwv tsis ncaj, uas yog, cov tshuaj los ntawm ib pawg pharmacological (hauv qhov no, reductase inhibitors) uas muaj cov nyhuv zoo sib xws, tab sis muaj cov tshuaj sib txawv. Cov tshuaj no yog cov tshuaj pov thawj tsis sib xws thiab tuaj yeem yog tus kws tshaj lij tshwj xeeb los ntawm cov kws tshaj lij nyob rau ntawm lub hauv paus ntawm cov ntaub ntawv kuaj.

Sib piv cov lus ntawm cov nqi ntawm analogues ntawm "Rosuvastatin"

Rau cov laj thawj ntawm txoj kev tshawb no, ua rau txoj kev nyiam ntawm cov neeg tau txais kev pab ntawm cov tshuaj hauv cov lus nug, cov npe saum toj no muaj cov tshuaj analogues hauv cov tshuaj hauv qab thiab cov ntau: 10 mg ntawm rosuvastatin rau ib ntsiav tshuaj, 30 ntsiav tshuaj hauv ib pob. Daim ntawv ntawm qhov kev siv no yog qhov nrov tshaj plaws ntawm cov neeg siv khoom, vim tias nws raug nquahu kom pib tswj hwm cov tshuaj hauv ib hlis ib hlis txhawm rau txiav txim siab qhov kev hloov kho ntawm tib neeg lub cev mus rau rosuvastatin.

Tus nqi ntawm "Rosuvastatin" thiab lub peev xwm ntawm hloov nws nrog analogues

Hauv cov khw muag tshuaj saw "Rosuvastatin" hauv qhov tshuaj ntawm 10 mg thiab tus naj npawb ntawm cov ntsiav tshuaj, 30 daim yog muag nyob rau hauv tus nqi ntau ntawm 380 txog 490 rubles, nyob ntawm txoj cai nqe ntawm tus neeg muag khoom thiab xa tawm ntawm cov tshuaj lag luam, nrog rau thaj tsam ntawd. Yog li, feem ntau, qhov qub Rosuvastatin khoom yog qhov pheej yig dua li nws cov analogues, thiab nws raug nquahu kom yuav cov analogues nkaus xwb yog tias tsis muaj cov tshuaj tiv thaiv thawj hauv cov tshuaj no. Raws li cov kev txheeb xyuas tshaj tawm nyob rau hauv qhov chaw pej xeem hauv Is Taws Nem thiab hauv xov xwm luam ntawv, nws tseem tuaj yeem xaus lus tias cov neeg siv khoom nyiam nyiam cov tshuaj qub.

Cov hauv paus ntsiab lus ntawm cov tshuaj

Lub chaw muag tshuaj ntawm Krestor yog tias nws qhia tawm lub enzyme tshwj xeeb uas tswj kev tsim cov roj (cholesterol) ua ntej lossis mevalonate.

Cov tshuaj qaug tshuaj ntawm cov tshuaj ua rau ncaj qha rau hauv daim siab, uas ua rau cov rog.Qhov enzyme no pab txo qis cov lipoproteins uas muaj tsawg, uas pab txo cov roj hauv lub cev tag nrho, nrog rau triglycerides.

Txuas ntxiv, cov roj (high-density cholesterol) nce. Cov tshuaj no zoo rau cov neeg mob tsis hais hnub nyoog li cas, poj niam txiv neej thiab haiv neeg twg. Cov neeg siv tshuaj xyuas ntau lub tswv yim hais tias cov txiaj ntsig ntawm kev siv Krestor yog twb pom meej hauv thawj lub limtiam ntawm qhov kev kawm, thaum cov kev ua tau zoo tshaj plaws tau tiav tom qab ua tiav qhov kev kawm hauv 2-4 lub lim tiam ntawm kev siv tas li.

Tus ntoo khaub lig, tsis zoo li nws muaj ntau yam, muaj qhov tsis zoo ntawm tib neeg daim siab. Nws yog qhov zoo tshaj los ua ke nws txoj kev siv nrog cov khoom noj tshwj xeeb, nrog rau lwm cov tshuaj tswj qhov txo cov roj (cholesterol).

Cov chaw muag tshuaj ntawm cov tshuaj muaj raws li nram no:

1. Nyob rau hauv degree ntawm kev nqus. Qhov siab tshaj plaws ntawm statin tshwm nyob rau hauv cov ntshav tom qab 5 teev, tom qab siv cov tshuaj.
2. Hauv kev faib khoom hauv lub cev. Krestor thaj chaw tseem ceeb ntawm kev ua yog lub siab, uas tsim cov roj (cholesterol). Qhov xa khoom yog 134 litres.
3. Nyob rau hauv cov degree ntawm cov metabolism. Rau Krestor, nws yog kwv yees li 10%.
4. Nyob rau hauv txoj kev derivation. Tus nqi ntawm cov tshuaj uas raug tshem tawm los ntawm lub cev yog kwv yees li 90% hauv 19 teev ntawm kev tswj hwm.

Lub hnub nyoog ntawm tus neeg mob, nrog rau tub los ntxhais, muaj tiag tsis muaj kev cuam tshuam rau cov khoom lag luam pharmacokinetic ntawm cov tshuaj.

Koj yuav tsum them sai sai rau qhov muaj kab mob hauv lub raum. Yog li, mob me me thiab hauj sim ntawm lub raum tsis ua hauj lwm tsis cuam tshuam rau theem ntawm statin, thaum nyob rau hauv daim ntawv loj, qhov tsis haum ntawm rosuvastatin nce 3 zaug.

Lub xub ntiag ntawm daim siab pathologies xyaum tsis cuam tshuam rau kev siv yeeb tshuaj.

Krestor - analogues ntawm cov tshuaj thiab cim rau kev siv

Ib qho pheej yig dua cov tshuaj hloov pauv lossis hloov pauv rau cov tshuaj, yog tias tus neeg mob txiav txim siv nws, yuav tsum ua tib zoo saib.

Hauv lwm lo lus, cov neeg mob uas txiav txim siab los hloov cov tshuaj qub nrog cov tshuaj feem ntau yuav tsum tau sab laj nrog lawv tus kws kho mob lossis saib seb qhov twg qhia rau kev siv yog qhia hauv lawv cov lus qhia.

Thaum pib, Krestor pom zoo kom siv:

• nrog hypercholesterolemia,
• raws li kev tiv thaiv mob stroke thiab lub plawv nres,
• nrog mixed hypercholesterolemia,
• cov neeg mob atherosclerosis,

Tsis tas li ntawd, nws raug nquahu kom siv cov tshuaj nyob rau hauv muaj cov kab mob hypertriglyceridemia.

Cov lus qhia rau kev siv tshuaj

Krestor, zoo li lwm yam tshuaj, nws muaj nws lub tswvyim thiab kev siv ntau.

Raws li txoj cai, nws yog tus kws kho mob uas txiav txim siab ntau npaum li cas ntawm cov tshuaj uas tus neeg mob yuav tsum siv. Nws ua qhov no rau ntawm cov ntawv soj ntsuam thiab soj ntsuam tau.

Tsis tas li ntawd, qhov xwm txheej dav dav ntawm tus neeg mob thiab lub xub ntiag ntawm cov kab mob sib kis tau raug suav nrog.

Yog li ntawd, Krestor yuav tsum ua raws li hauv qab no:

1. Zuaj ib ntsiav tshuaj ntawm cov tshuaj.
2. Lub sijhawm tsim nyog tshaj plaws rau kev pub nkag mus yog suav tias yog yav tsaus ntuj muaj feem nrog kev nce qib hauv cov roj cholesterol hauv lub cev.
3. Noj mov tsis muaj kev cuam tshuam cov txiaj ntsig zoo ntawm kev siv tshuaj noj.
4. Ua ntej noj ib hom tshuaj ntawm cov tshuaj, tus neeg mob raug pom zoo kom ua raws li cov zaub mov muaj roj cholesterol tsawg.
5. Thaum pib, nws yog qhov yuav tsum tau noj cov tshuaj nyob rau hauv ib qho nyiaj ntawm 5-10 g nyob rau ib hnub. Txawm li cas los xij, qhov ntau npaum ntawm cov tshuaj tau xaiv xaiv ib tus zuj zus thiab los ntawm kws kho mob. Thaum tsis muaj cov txiaj ntsig ntawm cov tshuaj npaum li cas, nws tuaj yeem nce ntxiv rau 20 milligrams, tab sis tsuas yog tom qab ib hlis xwb. Ntau npaum li cas ntawm 40 milligrams yog tsuas yog qhia hauv qhov xwm txheej uas muaj kev pheej hmoo ntawm kev tsim cov hlab plawv cov ntshav siab kawg. Cov neeg mob uas mob hypercholesterolemia yuav tsum tau muaj kev saib xyuas tas li kom tsis txhob muaj kev phiv tshuaj.

Yog tias tus neeg mob tau noj tshuaj ntau dhau, tsis siv tshuaj tiv thaiv kab mob, kev txhawb nqa tau siv.

Cov piv txwv zoo ntawm Crestor

Hauv kev ua lag luam niaj hnub rau cov tshuaj, ntau cov tshuaj tau nthuav tawm. Txawm li cas los xij, raws li txoj cai, cov tshuaj qub yog kim heev thiab tsis yog txhua tus neeg mob muaj txoj hauv kev yuav lawv.

Hauv qhov no, ntau lub tuam txhab txiav txim siab los hloov cov khoom qub nrog analogues. Raws li txoj cai, qhov sib txawv tseem ceeb ntawm cov tshuaj no yog tus nqi.

Tsis tas li ntawd, nws tsim nyog txiav txim siab tias ib qho yeeb tshuaj twg lossis nws cov tshuaj tiv thaiv mob yuav tsum tau sau tseg los ntawm tus kws kho mob uas yuav suav nrog txhua tus cwj pwm ntawm tus kab mob thiab tus neeg mob lub neej muaj mob.

Ntawm cov analogues nrov tshaj plaws yog:

1. Akorta. Lavxias teb sab counterpart. Nws yog qhov zoo sib xws hauv kev txuam, nrog rau hauv kev qhia rau kev siv. Nws yog siv rau hauv kev kawm kom ntev raws li tau hais tseg.
2. Mertenil. Cov khoom siv tseem ceeb ua ke yog rosuvastatin. Nws yog cov duab hluav taws xob txawv teb chaws uas sib txig sib luag hauv nws cov chaw muag tshuaj nrog cov tshuaj qub. Ua hauv Hungary thiab pab txo qis cov cholesterol. Tus nqi - 510-1700 rubles.
3. Rosistark. Cov cuab yeej siv tau zoo uas raug muag ntawm tus nqi pheej yig heev. Ua ntej siv, nws raug nquahu kom koj nyeem cov lus qhia txhawm rau txhawm rau txo qhov muaj feem ntawm cov kev mob tshwm sim los ntawm nws siv. Tus nqi nyob rau nruab nrab ntawm 250 txog 790 rubles.
4. Rosucard. Lwm tus Lavxias teb sab counterpart. Cov tshuaj yeeb dej caw ua kom zoo ib yam, nrog rau cov tshuaj hauv ib lub ntsiav tshuaj. Contraindicated nyob rau hauv ntau ntawm rhiab heev rau active cov khoom xyaw.
5. Rosulip. Kev siv cov tshuaj no muaj feem cuam tshuam rau hauv thawj cov neeg mob hypercholesterolemia, hypertriglyceridemia, los txo qis kev nce qib ntawm atherosclerosis thiab tiv thaiv kab mob plawv. Nws tsim tawm hauv Hungary thiab raug nqi 390-990 rubles.
6. Kwv Txhiaj Ntsuag. Cov tshuaj tiv thaiv hypolipidemic. Nws tsis pom zoo kom siv thaum cev xeeb tub, thaum pub niam mis, nrog rau menyuam yaus hnub nyoog qis dua 18 xyoo. Tus nqi nruab nrab yog 440-1800 rubles Lavxias.
7. Tevastor Cov tshuaj uas yuav tsum tau siv tsawg kawg 4 lub lis piam rau cov nyhuv pom tau. Nws yog tsim hauv Ixayees thiab raug nqi kwv yees li 350-1500 rubles.
8. Novostat. Lub hauv paus ua haujlwm tseem ceeb yog atorvastatin. Cov tshuaj yog tsim nyob rau hauv Russia.

Tus nqi ntawm cov tshuaj no txawv thiab txawv ntawm 500 rubles rau 3 txhiab los yog ntau dua.

Kev tshuaj xyuas ntawm cov neeg mob thiab kws kho mob txog Crestor

Raws li kev xav ntawm cov kws tshaj lij kws kho mob, Krestor ua pov thawj yog cov tshuaj zoo dua uas pab txo qis cov roj cholesterol.

Hauv feem ntau cov neeg mob koom nrog qhov kev sim, qhov ntsuas cov roj (cholesterol) tau nce mus rau ib txwm nyob rau hauv ib lub lis piam, tom qab pib kev kawm.

Cov ntsiav tshuaj nyob rau hauv cov tshuaj khw yog qhov ua tau zoo, thiab yog li ntawd cov kev ua haujlwm ntawm kev siv tshuaj yog ntau dua. Raws li txoj cai, chav kawm ntawm cov tshuaj no tsis ua rau muaj phiv.

Raws li rau lub tswv yim ntawm cov neeg mob, nws tag nrho coincides nrog lub tswv yim ntawm cov kws kho mob. Feem ntau, muaj cov kev xav ntawm cov neeg mob uas tau mob hlab ntsha tawg lossis plawv nres.

Yog li, peb tuaj yeem xaus tias tshuaj yog qhov ua tau zoo. Nws tsuas yog siv sijhawm rau cov ntsuas no rov ua qub.

Kuv puas yuav tsum tau siv statins yuav qhia tus kws tshaj lij hauv cov yeeb yaj kiab hauv tsab xov xwm no.

• Stabilizes qib qab zib kom ntev
• Rov kho cov tshuaj insulin pancreatic

Kws Tshuaj

Tus neeg sawv cev hypolipidemic los ntawm pab pawg ntawm statins, ib qho inhibitor ntawm HMG-CoA reductase. Raws li lub hauv paus ntsiab lus ntawm kev sib tw kev sib tua, ib qho statin qauv qauv khi rau qhov ntawd ntawm coenzyme A receptor qhov twg no enzyme txuas. Lwm feem ntawm statin lwg me me tiv thaiv kev hloov pauv ntawm hydroxymethylglutarate rau mevalonate, ib qho nruab nrab hauv cov hluavtaws sib xyaw ua ke ntawm cov roj (molecules) roj.Kev txwv tsis pub muaj kev ua haujlwm ntawm HMG-CoA reductase ua rau muaj cov kev hloov tshwm sim ntxiv, uas ua rau cov roj ntsha tsis txaus siab thiab muaj kev cuam tshuam ntau ntxiv hauv kev ua haujlwm ntawm LDL receptors thiab, raws li, muaj kev cuam tshuam catabolism ntawm LDL cov roj (Xc).

Cov nyhuv hypolipidemic ntawm statins yog txuam nrog qhov kev txo qis ntawm tag nrho cov cholesterol vim LDL cov cholesterol. Qhov txo qis hauv LDL yog koob tshuaj-siv thiab tsis yog linear, tab sis exponential.

Statins tsis cuam tshuam rau kev ua haujlwm ntawm lipoprotein thiab hepatic lipases, tsis txhob cuam tshuam loj heev ntawm kev sib txuas thiab catabolism ntawm cov roj ntsha dawb, yog li ntawd, lawv cov txiaj ntsig ntawm theem TG yog theem nrab thiab tsis ncaj los ntawm lawv cov kev cuam tshuam tseem ceeb los txo qis LDL-C. Kev poob qis hauv theem ntawm TG thaum kho nrog statins pom meej cuam tshuam nrog kev qhia ntawm cov seem (apo E) receptors nyob rau saum npoo ntawm hepatocytes koom nrog catabolism ntawm STD, uas muaj li 30% TG.

Ntxiv rau qhov teebmeem lipid-txo qis, statins muaj cov txiaj ntsig zoo ntawm endothelial kawg (preclinical kos npe ntawm thaum ntxov atherosclerosis), nyob rau ntawm phab ntsa vascular, atheroma lub xeev, txhim kho rheological ntshav, muaj antioxidant, antiproliferative zog.

Kev kho mob ua kom pom tshwm sim nyob rau hauv 1 lub lim tiam. tom qab pib txoj kev kho thiab tom qab 2 lub lis piam ntawm kev kho yog 90% ntawm lub siab tshaj plaws ua tau cov txiaj ntsig, uas feem ntau ua tiav los ntawm 4 lub lis piam thiab tom qab ntawd tas mus li.

Analogs los ntawm qhov taw qhia thiab cov qauv ntawm kev siv

Sib txawv muaj pes tsawg leeg, tuaj yeem ua ke nyob rau hauv kev taw qhia thiab cov qauv ntawm daim ntawv thov

Txhawm rau kom ua ib daim ntawv teev cov khoom pheej yig ntawm cov tshuaj pheej yig, peb siv cov nqi uas yuav muab peb ntau tshaj 10,000 khw muag tshuaj thoob plaws hauv tebchaws Russia. Cov ntaub ntawv teev npe ntawm cov tshuaj thiab lawv cov analogues tau hloov kho tshiab txhua hnub, yog li cov ntaub ntawv muab rau ntawm peb lub vev xaib yog ib txwm hloov kho raws li niaj hnub no. Yog tias koj tsis tau pom ib qho analogue ntawm kev txaus siab rau koj, thov siv qhov kev tshawb nrhiav saum toj no thiab xaiv cov tshuaj ntawm kev txaus siab rau koj los ntawm cov npe. Ntawm nplooj ntawv ntawm txhua ntawm lawv koj yuav pom tag nrho cov kev xaiv ua tau rau cov qauv ntawm cov tshuaj xav tau, nrog rau tus nqi thiab chaw nyob ntawm cov khw muag tshuaj uas nws muaj.

Dab tsi analogues tuaj yeem hloov rosuvastatin?

Rosuvastatin yog cov tshuaj siv los kho cov metabolism hauv rog. Cov tshuaj yog dav siv rau kev tiv thaiv thiab kho mob ntawm cov kab mob ntawm cov hlab plawv.

Kev npaj muaj rosuvastatin raws li cov khoom muaj sia yog tsim los ntawm ntau tus neeg txawv teb chaws thiab txawv teb chaws. Tus thawj tshuaj hu ua Crestor yog tsim nyob rau hauv UK los ntawm Astra Zeneca. Cov tshuaj uas tseem tshuav nyob nrog rosuvastatin yog nws cov generics.

Piv txwv, Rosuvastatin Canon, Torvacard, Rosulip, Akorta, Rosistark, Tevastor, Rosart, Rosuvastatin-SZ, Mertenil.

Rosuvastatin "tuaj yeem hloov nrog qee qhov khoom noj zoo

Cov tshuaj qub thiab generics

Cov generics zoo li cas thiab txawv li cas ntawm cov thawj? Generics yog kev luam tawm cov ntawv luam ntawm cov tshuaj qub. Cov tshuaj yeeb dej caw hauv thawj cov tshuaj thiab cov generics yog tib yam. Thiab cov lus ntawm cov khoom siv ntu yuav txawv.

Vim li cas cov analogues pheej yig dua li qhov qub? Qhov tseeb yog tias lub chaw tsim khoom ntawm cov khoom qub yog “tus khav theeb”.

Qhov no txhais tau tias nws tau siv nyiaj ntau heev rau kev ua cov haujlwm hauv kev kuaj mob thiab kev tshawb nrhiav cov tshuaj, thiab tseem tau txais daim ntawv patent rau cov tshuaj tshiab. Cov txheej txheem kim heev no suav nrog tus nqi tshuaj.

Cov neeg tsim khoom lag luam ntawm cov generics tsis dais cov nqi loj, lawv tsuas tsim cov twj, uas tso cai rau lawv muag nws ntawm tus nqi qis.

Yog li, xav txog ib cov tshuaj uas yog ib qho tshuaj noj ntawm cov qub Rosuvastatin (Crestor).

Tus mob ntshav qab zib nyob rau lub sij hawm kho nrog Krestor yuav tsum ua tib zoo saib xyuas

Rosuvastatin Canon

Ib cov tshuaj no yog Rosuvastatin Canon. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm 10, 20 thiab 40 mg. Cov tshuaj muaj lipid-txo cov khoom. Cov ntsiab lus rau kev teem caij ntawm Rosuvastatin Canon yog:

• thawj hypercholesterolemia,
• tsev neeg homozygous hypercholisterinemia,
• kom ntshav triglycerides,
• kev tiv thaiv ntawm cov kev mob hnyav ntawm atherosclerosis,
• kev tiv thaiv ntawm IHD lwm yam mob uas tsis muaj qhov ntsuas mob,
• ntxiv rau kev noj haus ntawm kev pheej hmoo ntawm kev tsim mob atherosclerosis.

Cov tshuaj yog teem los ntawm kev kawm ntev ntawm kev kho, pib nrog kev noj tsawg kawg nkaus. 3-4 lub lis piam tom qab pib kev kho mob, tus neeg mob tau raug ntsuas ntshav kom soj ntsuam qhov ua tau zoo ntawm kev kho mob.

Yog tias cov theem ntawm cov roj (cholesterol) thiab triglycerides hauv cov ntshav tseem siab lossis qis dua me ntsis, kev noj tshuaj ntau dua yuav tsum kho.

Ua kom cov koob tshuaj yog nqa tawm maj nrog cov sij hawm xyuas ntawm cov ntshav suav.

Rosuvastatin Canon - Tus neeg sawv cev hypolipidemic los ntawm pab pawg ntawm statins, ib qho tshuaj tiv thaiv ntawm HMG-CoA reductase

Thaum twg yuav tsum tau cov tshuaj statins?

Rosuvastatin, zoo li lwm yam statins, muaj ib tug xov tooj ntawm contraindications, nyob rau hauv uas nws yog txwv tsis pub sau ntawv siv tshuaj ntawm pab pawg no.

1. Kev tsis haum xeeb rau cov tshuaj nquag lossis cov koom tes pabcuam ntawm cov ntawv tshuaj.
2. Cov kab mob mob siab nyob hauv cov theem nquag lossis nce qib siab ntawm qhov kev hloov pauv ntawm cov tsis paub keeb kwm ntau dua 3 zaug.
3. Lub sijhawm uas xeeb menyuam thiab pub mis niam.
4. Tsis muaj kev tiv thaiv tsim nyog hauv cov poj niam uas muaj hnub nyoog deev.
5. Mob raum nrog rau kev ua kom lub raum tsis ua haujlwm.
6. Cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo.
7. Myopathy
8. Lub sijhawm kho nrog cyclosporine.

Cov tshuaj tiv thaiv tsis haum ntawm cov tshuaj Rosuvastatin Canon yuav tsum tau coj mus rau hauv kev txiav txim siab thaum xaiv nws. Qhov no yuav zam kev txhim kho kev phiv tshuaj los ntawm cov plab hnyuv siab raum tseem ceeb thiab cov kab ke.

Muaj teeb meem tshwm sim ntawm rosuvastatin kev kho mob

Yuav muaj teeb meem dab tsi tshwm sim thiab cuam tshuam thaum kho nrog cov tshuaj qub thiab rosuvastatin hloov chaw? Kev kho mob Statin feem ntau zoo tiv thaiv. Qhov no siv rau ob qho tib si thawj cov tshuaj thiab pheej yig cov tshuaj tiv thaiv ntawm rosuvastatin.

Kev siv cov statins tuaj yeem ua rau mob nqaij.

Txawm li cas los xij, yog tias qhov tshuaj ntau dua los yog muaj teeb meem nyob rau ntawm ib feem ntawm lwm cov plab hnyuv siab raum thiab cov tshuab, kev kho mob ntawm Rosuvastatinomy nrog nws cov analogues tuaj yeem ua rau tsis pom kev tsis haum.

1. Quincke's edema thiab lwm yam tshuaj tiv thaiv kab mob.
2. Cov kab mob ntawm cov endocrine system (hom 2 mob ntshav qab zib mellitus).
3. Dyspeptic mob.
4. Pancreatic o.
5. Kev cuam tshuam ntawm daim siab.
6. Mob leeg, mob myositis, rhabdomyolysis (rhuav tshem cov leeg nqaij).
7. Lub raum tsis zoo.
8. Hloov hauv chaw kuaj ntshav thiab kuaj ntshav.

Yog tias koj ntsib cov tsos mob uas tsis muaj cov yam ntxwv ntawm tus kab mob tseem ceeb, koj yuav tsum sab laj nrog kws kho mob sai. Tus kws kho mob tshwj xeeb yuav txiav txim qhov tseeb ntawm qhov mob thiab yog tias tsim nyog, kho qhov kev kho mob thiab qhov ntau npaum li cas.

Cov kev cai rau kev siv tshuaj pab

Yuav ua li cas noj Rosuvastatin thiab nws cov analogues? Cov tshuaj kho kom haum yog qhov ua kom siab tshaj plaws thiab txo qhov kev pheej hmoo ntawm cov teeb meem saum toj no ntawm kev kho. Yog li, cov kev cai yooj yim ntawm kev kho yog li nram no.

1. Cov tshuaj yuav tsum noj kom tag nrho, yam tsis muaj kev zom. Haus cov tshuaj nrog dej ntshiab kom ntau txaus.
2. Yog tias koj xav noj me dua li muaj ib ntsiav tshuaj, daim ntawv tshuaj yuav muab faib ua ib nrab.
3. Cov poj niam muaj hnub nyoog yug me nyuam thaum cev xeeb tub yuav tsum siv txoj hauv kev tiv thaiv kom tsis muaj menyuam.
4. Yog tias cev xeeb tub thaum kho nrog statins, cov tshuaj yuav tsum tsis ua mus ntxiv. Rho menyuam tsis tas yuav.
5. Thaum siv tshuaj kho, nws raug txwv tsis pub kom muaj kev ywj pheej txo lossis nce cov tshuaj ntawm txhua hnub.
6. Yog tias cov tshuaj tsis yog yuam kev, yuav tsum tau noj tshuaj ntxiv mus raws li cov qauv ib txwm muaj.

Cov kws tshaj lij tsis pom zoo kom noj cov tshuaj statins ntawm lawv tus kheej

Nws tseem yuav tsum raug sau tseg tias tawm tsam tom qab ntawm kev kho mob statin, koj yuav tsum ua raws li cov zaub mov noj muaj roj thiab roj (cholesterol) tsawg. Kev noj haus yuav tsum muaj calories tsawg, muaj cov rog tsiaj rog tsawg li sai tau.

Cov rog ntau hom ntses, nqaij thiab cov khoom noj siv mis yuav tsum tau muab tshem tawm kom tag. Cov tais diav yuav tsum muaj protein tsawg txaus thiab cog qoob loo.

Raws li cov khoom noj muaj protein, nqaij qaib nqaij, nqaij qaib ntxhw, tsev cheese, cov mis nyuj tsis muaj rog yog tsim nyog.

Koj yuav tsum noj zaub ntau, txiv hmab txiv ntoo, tshuaj ntsuab, kua txiv tshiab. Tsis txhob noj zaub mov ua rog, kib thiab luam yeeb. Tsis suav cawv, khoom noj ceev thiab dej qab zib.

Koj tuaj yeem ua noj siv ob npaug rhaub dej, los ntawm kev ci, hau. Nws raug nquahu kom tsis txhob siv cov roj, cov txuj lom thiab cov roj kub hauv kev ua noj.

Ua raws li cov cai ntawm khoom noj khoom haus loj txiav txim siab kev ua tiav ntawm kev kho.

Yam tshuaj twg zoo dua?

Yog li, rov qab rau cov yeeb yaj kiab ntawm Rosuvastatin, nws yuav tsum tau hais tias lawv yuav hloov tau cov tshuaj qub. Thiab tsis tau, uas yog qhov zoo dua - qub lossis qauv? Nws yog twv yuav raug hu tsis tau teb cov lus nug, vim tias muaj ntau lub tswvyim sib txawv ntawm cov kws tshwj xeeb hauv qhov no.

Qee tus neeg ntseeg tias cov tshuaj qub yog "ntxuav" thiab tsawg dua yuav ua rau muaj kev tsis haum xeeb. Tsis tas li ntawd, qee cov kws kho mob sau cia tias qhov ua tau zoo dua qub dua li nws cov ua haujlwm.

Yog li ntawd, tus kws kho mob tuaj yeem ua tus coj los ntawm ntau yam kev txiav txim siab, sau ntawv rau tus neeg mob ob qho tib si hauv kev kho kom zoo thiab nws cov lus txhais.

Cov lus qhia ntxaws ntxaws txog cov tshuaj uas nrov tshaj plaws thiab tsis pheej yig rau cov tshuaj "Rosuvastatin"

Rosuvastatin yog ib qho zoo tshaj plaws thiab siv dav siv tshuaj lipid-txo qis. Yog tias, rau qee qhov laj thawj, piv txwv li, qhov tsis muaj chaw muag tshuaj hauv zos lossis cov nqi siab, tus neeg mob tsis tuaj yeem yuav cov tshuaj qub, tom qab ntawd nws tuaj yeem hloov los ntawm cov tshuaj ntxiv pheej yig, ntawm uas muaj ntau Rosuvastatin.

Cov ntaub ntawv dav dav txog cov tshuaj thiab cov lus qhia rau kev siv

Rosuvastatin (Rosuvastatin) - Qhov no yog qhov lipid-txo cov tshuaj ntawm cov IV dhau los (tshiab) los ntawm ib pawg pharmacological ntawm cov statins, cov khoom xyaw tshuaj uas yog tshuaj lom neeg ntawm tib lub npe rosuvastatin nyob rau hauv daim ntawv ntawm calcium ntsev (calcium rosuvastatin).

Cov tshuaj no yog npaj rau kev kho los ntawm cov roj (hypercholesterolemia) tsis tu ncua, uas tsis yog qhov zoo txaus rau kev kho mob nrog cov tsis siv tshuaj. Nws kuj tseem raug txiav txim siab ua ib feem ntawm txoj kev kho mob nyuaj rau lwm cov ntawv ntawm cov roj ntsha tsis txaus (dyslipidemia), rau kev tiv thaiv kev mob plawv thiab tshem tawm cov kev hloov kho atherosclerotic ntawm cov phab ntsa ntawm cov hlab ntsha.

Qhov kev txiav txim ntawm statins yog ua raws li kev txwv tsis pub muaj enzyme, uas yog lub luag haujlwm rau kev tsim cov cholesterol los ntawm lub siab (qhov chaw txog li 80% ntawm cov tshuaj).

Mechanism ntawm kev ua Rosuvastatin muaj nyob rau hauv thaiv cov enzyme - HMG-CoA reductase, uas yog "lub cev xeeb menyuam" ntawm cov tshuaj tua kabmob ua kom muaj kabmob (Chol, cholesterol) hauv lub siab. Vim tias qhov no, tus naj npawb ntawm cov neeg tau txais kev tiv thaiv kom tsawg rau cov lipoproteins uas tsis muaj ntau ntxiv, uas ua rau cov txheej txheem ua rau lawv cov hniav lwj thiab nthuav tawm ntawm lub cev.

Yog li ntawd, tawm tsam cov keeb kwm yav dhau los ntawm kev siv tshuaj, muaj qhov txo qis ntawm cov "roj" phem (LDL, LDL), thiab cov qib "cov roj" zoo (HDL, HDL) hauv cov ntshav kuj tau them rov qab.

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab-cov ntsiav tshuaj, uas yuav tsum tau noj tshwj rau sab hauv (qhov ncauj), nrog tsawg kawg 100-150 ml dej, txhua lub sijhawm ntawm hnub, tsis hais noj zaub mov.

Lub qub qauv ntawm Rosuvastatin suav nrog mis qab zib (lactose) monohydrate, lub xub ntiag uas ua rau cov tshuaj tsis raug rau cov neeg mob uas tsis nkag mus rau cov feem no thiab cov neeg muaj lactase tsis txaus.

Kev kho kiag Rosuvastatin raug xaiv los ntawm tus kws kho mob nruj me ntsis ntawm tus kheej, raws qhov mob hnyav hauv txhua kis. Kev txais tos yuav pib nrog qhov tsawg kawg nkaus (5-10 mg ib hnub ib zaug) thiab nce raws li qhov tsim nyog (muab rau tsis muaj kev phiv).

Kev hais tawm lipid-txo cov nyhuv tuaj yeem pom tom qab 7-9 hnub tom qab pib kho, thiab tom qab 2-4 lub lis piam nws nce mus txog 90-100% ntawm qhov txiaj ntsig siab tshaj plaws, uas tau tswj xyuas thoob plaws tag nrho cov kev kawm ua ntu zus ntawm Rosuvastatin.

Cov tuam txhab tsim khoom twg zoo dua?

Tus thawj cov tshuaj Rosuvastatin tau tsim los ntawm Japanese tuam txhab Shionogi & Co. (Shionogi & Co), txawm li cas los xij, nws cov analogues yog tsim nyob rau hauv cov npe thoob ntiaj teb tsis muaj npe (INN) los ntawm lwm lub tuam txhab tshuaj:

• Lavxias - Cov Kws Muag Tshuaj (Phstandard), Ozone (Ozon), Canonfarma (Kanonfarma), FI Obolenskoye (OBL Pharm),
• tuaj txawv tebchaws - Astra Zeneca (Astra Zeneca), Gideon Richter (Gedeon Richter), Actavis (Actavis), Belupo (Belupo).

Tag nrho cov tuam txhab no tsim cov generics, i.e., luam yeeb tshuaj, cov tshuaj tiv thaiv tseem ceeb ntawm uas yog tib lub rosuvastatin, tab sis lawv txawv ntawm kev pib txhim kho los ntawm cov txheej txheem thev naus laus zis ntawm kev tsim khoom, kev lag luam lub npe thiab qhov sib piv ntawm cov neeg zam.

Txij li cov piv txwv ncaj ncaj yuav luag sib luag nrog cov thawj, txij li qhov pom ntawm nws cov hauj lwm zoo, nws tsis tseem ceeb dab tsi uas lub tuam txhab muab kev nyiam rau thaum yuav khoom, tab sis muab hais tias Rosuvastatin noj rau lub sijhawm ntev, nws ua rau muaj kev txiav txim siab saib xyuas cov tshuaj muaj nqi pheej yig dua.

Cov analogues nto moo tshaj plaws thiab hloov chaw rau rosuvastatin

Ua ntej txiav txim siab qee yam tshwj xeeb thiab hloov pauv rau Rosuvastatin, nws tsim nyog sau cia tias, txawm tias tau teem caij mus ntsib tus kws kho mob, tus neeg mob muaj cai xaiv qhov tsis tas li, tsom mus rau nws tus kheej nyiam, lub hnab nyiaj thiab tus neeg tsis txaus siab rau cov khoom xyaw ntxiv hauv cov lus muaj. Qhov loj tshaj plaws yog kev ua raws li cov koob tshuaj muaj qhia thiab kev coj ua tshuaj.

Roxera muaj cov tshuaj muaj zog tshwj xeeb tshaj plaws uas tso cai rau rosuvastatin tso tawm tshwj xeeb rau hauv txoj hnyuv me, qhov twg cov ntsiav tshuaj tau nqus dej tsis hloov, thiab tsis raug cuam tshuam los cuam tshuam ntawm lub plab ua kua.

Cov yam ntxwv ntawm muaj pes tsawg leeg: butyl methacrylate thiab methyl methacrylate copolymer ntxiv rau lub plhaub.

Tuam txhab tsim khoom lag luam: KRKA, Slovenia.

Tus nqi tshuaj: los ntawm 383 RUB / 30 pcs 5 mg txog 1617 rubles / 90 pcs. 20 mg txhua.

Rosucard (Rozucard) yog tus cwj pwm los ntawm kev siv lub cev zoo (ntau dua 20%), tab sis cov tshuaj rosuvastatin tau sai sai tawm ntawm lub cev, thiab yog li ntawd cov tshuaj muaj cov cim zoo tshaj plaws rau kev kho mob.

Cov yam ntxwv ntawm muaj pes tsawg leeg: es tsis txhob hypromellose los ntawm thawj qhov qauv, croscarmellose yog siv los ua hmoov ci.

Tuam txhab tsim khoom lag luam: Zentiva, Czech koom pheej.

Tus nqi tshuaj: los ntawm 613 rub. / 30 pcs. 10 mg rau 2708 rubles / 90 pcs. 40 mg txhua.

Cov kws kho mob pom zoo

Txo cov roj (cholesterol) kom tsawg thiab tiv thaiv atherosclerosis yam tsis muaj kev phiv, cov kws txawj pom zoo choledol. Tshuaj niaj hnub:

• raws amaranth siv hauv kev kho mob plawv,
• tsub kom cov cholesterol ntau "zoo", txo cov khoom "siab" los ntawm lub siab,
• txo txoj kev pheej hmoo ntawm lub plawv nres thiab mob hlab ntsha tawg,
• pib ua yeeb yam tom qab 10 feeb, qhov tshwm sim tseem ceeb yog pom tshwm tom qab 3-4 lub lis piam.

Kev ua tau zoo yog paub tseeb los ntawm kev kho mob thiab kev tshawb fawb ntawm Lub Tshawb Fawb Lub Chaw Kho Mob.

Mertenil (Mertenil) muaj qhov siab ntawm kev ua kom huv ntawm cov khoom ua kom nquag plias. Qhov no ua kom zoo tiv thaiv cov tshuaj muaj tsawg dua kev phiv, uas yog qhov tshwj xeeb tshaj yog thaum noj rosuvastatin hauv cov neeg laus.

Cov yam ntxwv ntawm muaj pes tsawg leeg: sib haum nrog qhov qub, tshwj tsis yog rau cov tshuaj uas siv los pleev xim lub plhaub.

Tuam txhab tsim khoom lag luam: Gedeon Richter, Hungary.

Cov nqi hauv cov chaw muag tshuaj: los ntawm 478 rub. / 30 pcs. 5 mg txog 1439 rubles / 30 pcs. 40 mg txhua.

Rosulip (Rosulip) yog cov tshuaj pheej yig dua ntawm Rosuvastatin, uas muaj lub siab ua kom zoo dua thiab maj mam ua kom zoo, uas tso cai rau koj los ua kom maj mam tsim cov tshuaj kho qhov xav tau ntawm cov tshuaj nquag hauv lub cev.

Cov yam ntxwv ntawm muaj pes tsawg leeg: muaj cov rosuvastatin tsis yog nyob rau hauv daim ntawv ntawm calcium, tab sis nyob rau hauv daim ntawv ntawm zinc ntsev (rosuvastatin zinc).

Tuam txhab tsim khoom lag luam: EGIS (EGIS Pharmaceuticals PLC), Hungary.

Tus nqi tshuaj: los ntawm 469 RUB / 28 pcs 5 mg txog 1087 rubles / 28 pcs. 20 mg txhua.

Crestor (Crestor) - tsuas yog thawj cov tshuaj raws rosuvastatin. Cov tshuaj yeeb yaj kiab no tau tsim los ntawm cov txheej txheem ua haujlwm zoo ntawm cov tshuaj yeeb dej caw thiab, yog tias koj tso siab rau cov neeg mob cov lus pom zoo, kev nkag siab zoo dua, tab sis ntawm tus nqi nws tseem kim tshaj li lwm cov generics.

Cov yam ntxwv ntawm muaj pes tsawg leeg: Tag nrho cov khoom xyaw yog zoo tib yam rau hauv daim ntawv qhia thawj.

Tuam txhab tsim khoom lag luam: Astra Zeneca, United Kingdom.

Cov nqi hauv cov chaw muag tshuaj: los ntawm 1756 rub. / 28 pcs. 5 mg txhua rau 5036 rub./28 pcs. 40 mg txhua.

Tevastor yog ib qho zoo tshaj plaws analogues ntawm Rosuvastatin, vim nws sai sai hauv lub cev, ua rau lub suab tawm suab kho, thiab tib lub sijhawm raug nqi ntau pheej yig dua li cov tshuaj qub.

Cov yam ntxwv ntawm muaj pes tsawg leeg: yuav luag cov lenten zoo ib yam li daim tseem (tshwj tsis yog zas xim).

Tuam txhab tsim khoom lag luam: TEVA (TEVA Pharmaceutical Industries Ltd), Ixayees.

Tus nqi tshuaj: los ntawm 341 rub. / 30 pcs. 5 mg txog 1522 rubles / 90 pcs. 20 mg txhua.

Rosuvastatin-SZ

Rosuvastatin-SZ (Rosuvastatin-SZ) - niaj hnub no nws yog qhov hloov pheej yig tshaj rau Rosuvastatin los ntawm cov chaw tsim khoom hauv Lavxias. Txawm hais tias tus nqi tsawg heev, nws tsis qis dua nyob rau hauv zoo rau lwm yam generics thiab tseem muaj cov khoom zoo ib yam rau thawj.

Cov yam ntxwv ntawm muaj pes tsawg leeg: hlau oxide siv los ua zas yog hloov los ntawm cov kua roj vanish ntawm peb ntau hom.

Tuam txhab tsim khoom lag luam: FC Severnaya Zvezda ZAO, Russia

Tus nqi tshuaj: los ntawm 178 rub. / 30pcs. 5 mg txog 684 rubles / 30 pcs. 40 mg txhua.

Ntxiv nrog rau statins, muaj lwm yam txhais tau tias. Cov nyeem nyeem ntawv pom zoo tshuaj ntuj, uas, ua ke nrog kev noj haus thiab kev ua si, txo qis cov roj (cholesterol) tom qab 3-4 lub lim tiam. Cov tswv yim ntawm cov kws kho mob >>

Rosart (Rosart) muaj txhua qhov zoo ntawm cov tshuaj qub thiab tsis tshua muaj cov txiaj ntsig tsis zoo rau lub cev, vim tias ob qho tib si cov tshuaj nquag thiab cov khoom siv pabcuam tau muab ntxuav kom huv. Peb tuaj yeem hais tias qhov no yog qhov hloov tau ntau tshaj plaws rau rosuvastatin.

Cov yam ntxwv ntawm muaj pes tsawg leeg: tag nrho cov khoom xyaw yog tib yam li hauv kev npaj thawj zaug.

Tuam txhab tsim khoom lag luam: Actavis Pawg, Iceland

Cov nqi hauv cov chaw muag tshuaj: los ntawm 426 RUB / 30 pcs 5 mg rau 2347 rub./90 pcs. 40 mg txhua.
Cov khoom uas txo cov roj cholesterol thiab ntxuav cov hlab ntshav.

Txhua hom tshuaj zoo tshaj plaws rau cov roj (cholesterol) zoo hauv daim ntawv ntawm cov ntsiav tshuaj.

Pheej yig tus qauv hloov thiab hloov pauv rau cov tshuaj hla rau cov menyuam thiab cov laus

Cov tshuaj Krestor yog ib qho lipid-txo cov tshuaj nyob hauv pawg pawg ntawm satins.

Kev nquag ua haujlwm yog rosuvastatin, uas ua rau tag nrho cov roj cholesterol, tshem tawm qhov ua rau endothelial tsis ua haujlwm thaum ntxov atherosclerosis, txhim kho lub xeev ntawm cov hlab ntsha, lub xeev ntawm atheroma, thiab rheological ua haujlwm ntawm cov ntshav. Antioxidant thiab antiproliferative cuam tshuam nyob rau hauv lub cev yog sau tseg.

Cov lus qhia rau kev siv muaj xws li lub xeev ntawm hypercholesterolemia, suav nrog tsev neeg homozygous. Cov tshuaj tiv thaiv tsis raug rau cov tshuaj muaj raws li nram no: cev xeeb tub, lactation, menyuam yaus thiab tub ntxhais hluas txog 18 xyoo, kab mob siab, mob raum nyob rau theem nquag.

Cov tshuaj uas tsim hauv Tebchaws Askiv thiab Puerto Rico muaj cov neeg hloov pauv zoo sib xws. Tus nqi ntawm Krestor ntsiav tshuaj tsis muaj rau txhua tus neeg mob: 800-9800 rubles. Pheej yig analogues ntawm cov tshuaj yog tsim los ntawm ob qho tib si domestic thiab txawv teb chaws.

Analogs ntawm Lavxias teb sab ntau lawm

Ukrainian hloov pauv

Yuav ua li cas los hloov cov tshuaj hla yeeb tshuaj, yog tias koj xav xaiv ib qho kev ua tsis raug nqi lus? Cov tshuaj Ukrainian haum suav nrog cov npe hauv qab no.

• KlivasCov. Qhov pheej yig tshaj plaws ntawm tus ntoo khaub lig nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Cov tshuaj muaj pes tsawg leeg suav nrog rosuvastatin. Cov tshuaj noj tau pab zoo rau lub xeev ntawm hypercholesterolemia, thiab kuj tseem siv hauv kev tiv thaiv kev mob plawv. Tus nqi nruab nrab yog 10-155 rubles.
• Cov AtorvacorCov. Atorvastatin nyob rau hauv cov qauv ntawm cov tshuaj ua rau cov lipid-txo cov nyhuv, txo cov ntshav hauv plasma cov ntshav. Qhov chaw ntawm kev txiav txim ntawm cov tshuaj yog daim siab mob hlwb, yog li ntawd, ntawm lub ntsiab contraindications yog daim siab tsis ua hauj lwm.Qhov tshuaj tseem raug txwv thaum cev xeeb tub thiab lactation. Tus nqi nruab nrab yog 140-220 rubles.

Belarusian generics

Belarusian cross generics yog qhov zoo tshaj plaws hloov rau pheej yig lipid-txo tshuaj nrog tib cov ntaub ntawv hauv cov lus qhia rau kev siv.

Cov lus qhia hauv qab no:

Lwm cov lus piv txwv txawv teb chaws

Niaj hnub sib txawv txawv cov lus ntawm rosuvastatin-based tus ntoo khaub lig:

• MertenilCov. Cov tshuaj phiv yog rosuvastatin. Kev taw qhia rau kev sau daim ntawv tshuaj muaj xws li dyslipidemic mob ua kom cov roj (cholesterol) tsawg dua.Qhov zoo tshaj plaws ntawm kev sib piv ntawm tus ntoo khaub lig hauv nws lub chaw muag tshuaj. Lub teb chaws ntawm hauv paus chiv keeb - Hungary. Tus nqi nruab nrab yog 510-1700 rubles.
• RosistarkCov. Cov tshuaj muaj txiaj ntsig zoo raws li rosuvastatin ntawm tus nqi pheej yig. Nws raug nquahu kom koj nyeem cov lus qhia rau kev siv tshuaj tiv thaiv kev mob, cov kev mob tshwm sim thiab cov xwm txheej uas yuav tsum tau saib xyuas thaum lub sijhawm tshuaj.Qhov tshuaj no tau tsim hauv Croatia. Tus nqi nruab nrab yog 250-790 rubles.
• TevastorCov. Cov lus sau rau cov tshuaj hauv cov lus nug nrog kev ua haujlwm zoo sib xws ntawm kev ua. Cov tshuaj yog siv rau lub sijhawm ntev - qhov kev kho mob ruaj khov pom tau tom qab 4 lub lis piam tom qab pib noj cov tshuaj nyob hauv tebchaws tebchaws yog Ixayees. Tus nqi nruab nrab yog 350-1500 rubles.
• Kwv Txhiaj NtsuagCov. Tus lipid-txo qis tus neeg sawv cev nrog kev ua haujlwm sib thooj zoo ib yam li tus ntoo khaub lig. Cov tshuaj no txwv thaum cev xeeb tub, pub niam mis, menyuam muaj hnub nyoog qis dua 18 xyoo. Tshuaj noj tshuaj Slovenian tso. Tus nqi nruab nrab yog 440-1800 rubles.
• RosulipCov. Cov ntsiav tshuaj nrog rosuvastatin nyob rau hauv kev sib xyaw ua ke txo qhov kev nthuav dav ntawm tag nrho cov roj cholesterol hauv cov ntshav ntshav. Tus nqi nruab nrab yog 380-990 rubles.

Thov nco ntsoov, cov tshuaj tiv thaiv tshuaj yeeb yaj kiab tuaj yeem muaj qhov sib txawv ntawm qhov ua kom zoo ntawm lub cev ntawm txhua tus neeg mob. Hauv cov lus qhia rau kev siv, ntau yam kev phiv tshuaj thiab cov sib txuam tsis sib haum tuaj yeem ua qhia. Tus kws kho mob tuaj yeem sau tshuaj rau lipid-txo cov tshuaj.

Kev kho mob hla kev tuaj yeem ua rau kiv taub hau, yog li koj yuav tsum tsis txhob koom nrog cov haujlwm uas yuav tsum muaj kev mloog ntxiv.

Kev qhia paub txaj muag

LUS QHIA
rau kev siv tshuaj kho mob
TSIM NYOG

Pharmacological kev txiav txim
Crestor yog ib tus neeg sawv cev lipid-txo qis. Cov tshuaj nquag siv ntawm cov tshuaj yog rosuvastatin - kev sib tw xaiv cov tshuaj tiv thaiv ntawm HMG-CoA reductase, ib qho enzyme uas hloov 3-hydroxy 3-methylglutaryl coenzyme A kom sai sai ntawm cov roj cholesterol - mevalonate. Qhov chaw ntawm kev thov ntawm kev ua ntawm rosuvastatin yog lub siab, qhov muaj catabolism ntawm cov roj lipoproteins tsawg (LDL) thiab kev tsim cov roj (cov cholesterol). Rosuvastatin nce tus naj npawb ntawm hepatic receptors rau qis lipoproteins tsawg ntawm cov xovtooj ntawm tes, uas ua rau kom muaj catabolism ntau zog thiab ua kom tsawg ntawm cov lipoproteins uas tsis muaj tsawg thiab inhibition ntawm kev tsim cov lipoproteins uas tsis tshua muaj siab (VLDL). Yog li ntawd, muaj qhov txo cov ntsiab lus ntawm cov lipoproteins uas muaj tsawg thiab tsis tshua muaj siab nyob rau hauv ntshav dej.
Rosuvastatin txo qis ntau ntxiv ntawm tag nrho cov roj (cholesterol), triglycerides thiab LDL cov roj (cholesterol), apolipoprotein B (ApoV), roj VLDL, cov roj (non-HDL), roj cholesterol VLDL, tag nrho cov roj cholesterol LDL / roj cholesterol HDL, tag nrho cov roj LDL / LDL / C Kuv. Rosuvastatin me ntsis nce cov ntsiab lus ntawm HDL cov roj (cholesterol) thiab ApoA-I (apolipoprotein A-I).
Qhov siab tshaj plaws ntawm Krestor nthuav dav tom qab 21 hnub ntawm kev nkag thiab tseem nyob tas li. Tom qab 7 hnub ntawm kev siv tshuaj, kho tshuaj nyhuv ntawm Krestor yog pom, thiab tom qab 14 hnub ntawm kev siv tshuaj, qhov ua haujlwm ntawm cov tshuaj yog 90% ntawm qhov ua tau ntau tshaj plaws.
Cov tshuaj yog tawm rau cov neeg laus uas muaj lossis tsis muaj hypertriglyceridemia thiab nrog hypercholesterolemia, tsis hais hnub nyoog li cas, poj niam txiv neej lossis haiv neeg twg. Cov tshuaj tseem tuaj yeem siv rau hauv cov neeg mob nrog kev mob ntshav qab zib lossis mob ntshav qab zib mellitus.
Thaum noj Krestor hauv qhov ntau npaum li 10 mg hauv 80% ntawm cov neeg mob uas muaj qhov nruab nrab theem qis ntawm LDL cov roj (cholesterol) ntawm 4.8 mmol / L (hypercholesterolemia IIa thiab hauv hom), qhov txo qis ntawm LDL cov roj ntsha mus rau mm3 mmol / L raug pom.Hauv cov neeg mob uas muaj tsev neeg hypercholesterolemia uas tau txais cov tshuaj ntawm qhov ntau npaum ntawm 20-80 mg, qhov hloov pauv zoo ntawm lipid profile yog pom (kev tshawb fawb soj ntsuam tau ua nrog kev koom tes ntawm 435 tus neeg mob).
Kev txo qis hauv LDL cov roj cholesterol los ntawm 53% tau pom nrog 12-lub lim tiam Crestor txoj kev kho tom qab them ib feem ntawm 40 mg / hnub, thiab LDL cov qib roj cholesterol ntawm cholesterol3 mmol / L tau ua tiav hauv 33% ntawm cov neeg mob. Hauv cov neeg mob uas muaj tsev neeg homozygous hypercholesterolemia, cov tshuaj tau raug tshuaj ntawm ntau npaum 20 thiab 40 mg, thiab tawm tsam keeb kwm ntawm kev kho mob Krestor, qhov txo qis hauv LDL cov cholesterol yog 22%.
Thaum ua ke nrog fenofibrate, ib qho cuam tshuam ntxiv (qib triglyceride) tau sau npe, uas tseem pom thaum ua ke nrog nicotinic acid (nrog rau HDL cholesterol).
Thaum tseem tsis muaj ntaub ntawv los ntsuas qhov txo qis hauv cov teebmeem los ntawm lipid profile teeb meem (piv txwv li, mob plawv plawv), kev sim hauv tsev kho mob tau txuas ntxiv.
Qhov siab tshaj plaws ntawm cov tshuaj nquag hauv cov ntshav ntshav tau pom kwv yees li 5 teev tom qab kev siv sab hauv ntawm Krestor. Bioavailability yog kwv yees li 20%. Cumulates hauv daim siab. Qhov ntim ntawm kev faib tawm rosuvastatin yog 134 litres. Kwv yees li 90% ntawm cov koob tshuaj muab rau noj yog khi los ntawm cov ntshav plasma protein (albumin).
Kwv yees li 10% ntawm ib koob tshuaj rosuvastatin undergoes metabolism hauv tsawg. Rosuvastatin yog lub hauv paus tsis-cov tshuaj rau metabolism hauv los ntawm P450 cytochrome system. Lub enzyme tseem ceeb uas metabolizes rosuvastatin yog CYP 2C9. Txhawm rau kom tsawg dua, cov enzymes CYP 3A4, CYP 2C19 thiab CYP 2D6 tau koom tes hauv cov metabolism hauv rosuvastatin. Lub ntsiab metabolites ntawm cov tshuaj nquag yog cov lactone metabolites thiab N-dismethyl. Thaum muab piv rau lawv, nws muab tawm tias N-dismethyl yog kwv yees li ib nrab (50%) tsis tshua muaj siab tshaj li rosuvastatin. Nws tau txiav txim siab tias lactone metabolites yog yam tshuaj tsis tau.
Qhov ntsuas nruab nrab ntawm cov tshuaj rosuvastatin muaj kwv yees li 50 l / h nrog qhov sib txawv ntawm 21.7 %. Kwv yees li 90% ntawm kev muab tshuaj yog tshem tawm tsis pauv los ntawm txoj hnyuv nrog quav, ob qho tsis rosuvastatin thiab nqus tau yog tawm. 10% ntawm cov tshuaj yog tshem tawm los ntawm ob lub raum. Ib nrab-lub neej yog kwv yees li 19 teev, uas yog ib txwm nrog rau kev nce cov tshuaj. Hauv cov txheej txheem ntawm hepatic ntes ntawm cov roj ntsha nquag ntawm cov khoom noj (zoo li nrog lwm HMG-CoA reductase inhibitors), cov kab mob hauv cov roj (cholesterol) tau koom nrog, uas ua lub luag haujlwm tseem ceeb hauv kev tshem tawm rosuvastatin los ntawm daim siab.
Kev raug rau lub cev zuj zus ntawm rosuvastatin nce ntxiv raws qhov sib npaug ntawm cov koob tshuaj muab. Nyob rau hauv cov ntaub ntawv ntawm kev noj ob peb koob tshuaj txhua txhua hnub, pharmacokinetic tsis ntawm lub active tshuaj ntawm Krestor tsis hloov.
Ib txoj kev sib piv hauv cov neeg mob uas nyob hauv Asia (Neeg Asmeskas cov neeg Asmeskas) tau qhia txog AUC thiab kev nce siab tshaj plaws ntawm rosuvastatin los ntawm 2 zaug, piv nrog cov ntaub ntawv los ntawm cov neeg nyob sab Europe thiab Asia. Qhov cuam tshuam ntawm ib puag ncig cov yam thiab cov caj ces ntawm txoj kev sib txawv hauv txiaj ntsig pharmacokinetic tsis tau kuaj pom. Tsis muaj qhov sib txawv tseem ceeb hauv cov chaw muag tshuaj ntawm rosuvastatin tau pom ntawm cov neeg mob ntawm cov haiv neeg ntawm Negroid thiab Caucasoid.
Yog tias lub raum tsis ua haujlwm (lub ntsws lossis nruab nrab), lub plasma cov ntsiab lus ntawm rosuvastatin thiab nws cov metabolite (N-dismethyl) tsis hloov pauv ntau. Hauv kev mob raum tsis zoo nrog qhov ua kom muaj qhov tsis txaus (adinine clearance) theem ntawm of30 ml / min, lub plasma qhov siab ntawm cov tshuaj nquag nce 3 zaug (thiab cov nquag metabolite, N-dismethyl, nce 9 zaug). Lub plasma concentration ntawm rosuvastatin hauv cov neeg mob uas tau txais cov mob hemodialysis ntau yog kwv yees li 50% ntau dua. Ib txoj kev tshawb ntawm cov qauv pharmacokinetic ntawm rosuvastatin hauv cov neeg mob raum tau ua piv nrog ib pab neeg noj qab haus huv.
Tsis muaj qhov nce ntxiv ntawm qhov kev txwv ntawm ib nrab-lub neej ntawm cov tshuaj nquag nyob hauv cov neeg mob uas muaj ntau qib ntawm daim siab ua haujlwm, uas tau raug ntsuas raws li Child-Pugh nplai ntawm 7 lossis tsawg dua cov ntsiab lus. Cov neeg mob ntsuas 8 thiab 9 ntawm Child-Pugh nplai qhia pom kev nce ntxiv hauv kev tshem tawm ib nrab-lub neej los ntawm tsawg kawg 2 zaug. Tsis muaj kev paub dhau los ntawm kev siv rosuvastatin hauv cov neeg mob uas tsis muaj kabmob hepatic nrog Child-Pugh qhab nia ntawm 9 lossis ntau dua.

Kev ntsuas rau siv
Kev kho mob ntawm atherosclerosis kom qeeb kev muaj mob ntawm cov neeg mob uas pom tias kev kho lipid-txo qis,
Thaum homozygous tsev neeg hypercholesterolemia ntxiv rau lwm qhov kev kho mob ntshav qab zib (piv txwv li, LDL-apheresis) lossis kev noj haus, zoo li hauv rooj plaub uas qhov kev kho mob ntawd tsis muaj txiaj ntsig,
· Xws li kev noj haus ntxiv - nrog rau kev sib xyaw hypercholesterolemia (hom IIB) nyob rau hauv rooj plaub thaum txoj kev tsis siv tshuaj (poob phaus, kev siv lub cev) thiab kev hloov pauv hauv kev noj zaub mov tsis muaj txiaj ntsig,
Thawj hom IIa hypercholesterolemia (suav nrog tsev neeg heterozygous hypercholesterolemia).

Txoj kev ntawm daim ntawv thov
Cov tshuaj siv ntawm qhov ncauj, ntxuav nrog dej, lub sijhawm txhua hnub ntawm hnub, tsis hais noj mov li cas. Tsis txhob zom.
Cov koob tshuaj ntawm Krestor raug xaiv raws li cov lus teb rau kev kho mob thiab lub hom phiaj ntawm kev siv rosuvstatin, thaum cov lus pom zoo rau cov qib lipoprotein yuav tsum tau siv rau hauv. Thaum kho nrog cov tshuaj, tus neeg mob tau noj tshuaj lipid-txo cov zaub mov (tus qauv) rau kev siv tas mus li.
Nyob rau hauv rooj plaub ntawm kev hloov pauv ntawm lwm qhov HMG-CoA reductase lossis rau thawj zaug teem caij ntawm Krestor, kev pib noj ntau dua 5-10 mg / hnub yog pom zoo. Txoj kev xaiv tshuaj yog nyob ntawm cov ntsuas cov roj (cholesterol) ntawm tus kheej, cov kev pheej hmoo ntawm cov tshwm sim thiab cov teeb meem pheej hmoo rau cov teeb meem yav tom ntej los ntawm cov hlab plawv. Nrog cov nyhuv tsis txaus, koj tuaj yeem nce ntau ntxiv rau ntawm Krestor tsis ntxov dua 21 hnub tom qab pib noj tshuaj (txij li qhov ua tau zoo tshaj plaws los ntawm lub sijhawm no). Noj Krestor ntawm koob tshuaj 40 mg ua rau muaj kev pheej hmoo ntawm kev phiv tshuaj ntau dua piv rau cov tshuaj qis dua, yog li nce Krestor ntau npaum li 40 mg / hnub raug tso cai tsuas yog muaj qhov pheej hmoo loj ntawm kev mob plawv mob ntshav qab zib (nrog rau cov neeg mob nrog tsev neeg hypercholesterolemia) thiab nrog mob hnyav hypercholesterolemia. Nce qhov ntau dua rau 40 mg / hnub yog nqa tawm tsuas yog qhov xav tau ntawm kev siv Crestor ntawm 20 mg / hnub tsis ua tiav, thaum tus neeg mob yuav tsum nyob hauv qab kev saib xyuas mob. Kev saib xyuas tshwj xeeb rau tus neeg mob ntawd yog qhov tsim nyog hauv thawj hnub ntawm kev noj tshuaj Krestor ntawm koob tshuaj 40 mg / hnub.
Nce cov koob tshuaj tau zoo yog tias qhov tsis txaus xav tau tshwm sim thaum noj ntau npaum li 20 mg thiab nyob rau hauv cov xwm txheej uas cov neeg mob yuav nyob hauv qab kev saib xyuas ntawm tus kws tshaj lij. Kev tswj tshwj xeeb raug pom zoo thaum pib noj 40 mg ntawm tshuaj.
Cov neeg mob nrog lub geriatric profile tsis tas yuav tsum tau kho ntau npaum li cas.
Nrog lub raum tsis ua haujlwm
Cov neeg mob uas kawm tsis mob me me tsis tas yuav tau yoog hloov kho. Rau cov neeg mob uas mob raum tsis txaus, lub sijhawm pib rosuvastatin yuav tsum yog 5 mg / hnub.
Qhov siab tshaj plaws niaj hnub noj tshuaj rau lub raum tsis ua haujlwm yog 40 mg / hnub, rau kev ua kom lub raum tsis ua haujlwm (nrog creatinine tshem tawm theem ≤60 ml / min) - 20 mg / hnub.
Lub sijhawm teem ntawm Krestor yog contraindicated rau hauv cov neeg mob uas lub raum tsis ua haujlwm loj.
Nrog daim siab ua haujlwm
Tsis muaj kev paub dhau los ntawm kev siv Krestor hauv cov neeg mob uas tsis muaj kabmob hepatic uas tau raug ntsuas rau qhov qhab nia Childe-Pugh ntawm 9 lossis ntau dua. Lub sij hawm teem tseg ntawm Krestor rau cov neeg mob mob siab nyob hauv theem nquag yog contraindicated.
Ib pawg haiv neeg
Ib qho kev nce ntxiv hauv cov kab ke ntawm rosuvastatin tau pom nyob hauv cov neeg mob ntawm haiv neeg Mongoloid. Cov neeg mob zoo li no yuav tsum pib kho nrog kev noj tshuaj ntau npaum li 5 mg / hnub, noj ntau kawg yog 20 mg / hnub. Lub sij hawm teem tseg ntawm Krestor rau cov neeg mob ntawm haiv neeg Mongoloid ntawm kev noj tshuaj ntawm 40 mg / hnub yog contraindicated.
Nrog txoj kev nyiam txhim kho myopathy
Hauv cov neeg mob uas muaj lub siab xav tawm ntawm myopathy, pib ntawm rosuvastatin yuav tsum yog 5 mg / hnub, qhov siab tshaj plaws - 20 mg / hnub. Cov sij hawm teem tseg ntawm koob tshuaj Crestor ntawm 40 mg / hnub yog contraindicated hauv cov neeg mob ntawd.
Sab sij huam
Qhov tshwm sim ntawm cov kev mob tshwm sim, zoo li lwm yam HMG-CoA reductase inhibitors, nyob ntawm seb siv ntau npaum li cas.
Qhov tshwm sim ntawm cov kev mob tshwm sim tau kwv yees raws li hauv qab no: cov kev mob tshwm sim tsis tu ncua (≥1 / 100, ≤1 / 10), cov kev mob tshwm sim tsis xws luag (≥1 / 1000, ≤1 / 100), cov kev mob tshwm sim tsis tshua muaj tshwm sim (≥1 / 10,000, ≤1 / 1000), kev mob tshwm sim tsis tshua muaj tshwm sim (≤1 / 10,000). Cov kev mob tshwm sim thaum siv Krestor yog ntaus nqi tsis txaus ntseeg thiab nres ntawm lawv tus kheej. Kev txiav ntawm txoj kev kho los ntawm Krestor thaum lub sijhawm sim tshuaj vim qhov tshwm sim ntawm cov kev mob tshwm sim yog 4% lossis tsawg dua.
Los ntawm cov hlab ntsha hauv lub cev: kiv taub hau, mob taub hau (feem ntau).
Los ntawm ib sab hauv lub nruab zog: cov tshuaj tiv thaiv ua xua (nrog rau cov mob hlwb) - tsis tshua muaj.
Los ntawm daim tawv nqaij thiab nws cov hnyuv tws: tawm pob, khaus khaus, urticaria (ua rau sab nraus).
Los ntawm cov leeg musculoskeletal: rhabdomyolysis thiab myopathy (tsis tshua muaj), mob leeg (feem ntau). Myopathy, mob leeg, thiab (tsis tshua muaj) rhabdomyolysis tau sau tseg hauv cov neeg mob uas tau siv ib qho tshuaj Crestor, tab sis tshwj xeeb tshaj yog rau cov neeg uas tau siv ntau npaum li 20 mg / hnub. Qhov koob tshuaj nce ntxiv hauv theem ntawm creatine phosphokinase (CPK), pom hauv cov neeg mob uas coj Krestor, feem ntau tsis tau hais tawm, hloov pauv thiab tsis muaj tsos mob. Nyob rau hauv qhov kev nce qib hauv qib ntawm CPK los ntawm 5 lossis ntau zaus, qhov kev nqus ntawm rosuvastatin nres.
Los ntawm kev mob plab hnyuv: cem quav, mob plab, xeev siab (feem ntau), mob pancreatitis (tsis tshua muaj).
Los ntawm cov kab mob urinary: tubular proteinuria. Muaj qhov hloov pauv ntawm cov protein nyob rau hauv lub tso zis hauv cov gradations los ntawm qhaj ntawv mus txog tsis muaj cov kua protein lossis txog li ob lub plahaum lossis ntau dua hauv ≤1% ntawm cov neeg mob uas tau sau tshuaj rau Crestor 10-20 mg / hnub. Thaum noj ib koob ntawm 40 mg / hnub, tus naj npawb ntawm cov neeg mob yog kwv yees li 3% ntawm cov neeg mob. Thaum siv Krestor ntau npaum ntawm 20 mg / hnub, tau nce me ntsis hauv cov protein nyob hauv cov zis tau pom. Proteinuria feem ntau poob qis los yog ploj nrog kev siv txuas ntxiv thiab tsis yog cov tsos mob ntawm kev txhim kho ntawm cov mob raum sai lossis kev loj hlob ntawm ib qho uas twb muaj lawm.
Los ntawm lub siab: hauv qee tus neeg mob tsawg, kev noj tshuaj ntau ntxiv rau hauv cov ntsiab lus ntawm transaminases tau sau tseg, zoo li nrog lwm HMG-CoA reductase inhibitors. Qhov nce ntawm transaminases feem ntau yog hloov, tsis muaj cov tsos mob thiab tsis tseem ceeb.
Lwm tus: asthenia (feem ntau).
Tom qab qhov kev qhia ntawm Krestor nthuav dav hauv kev kho mob, cov kev mob tshwm sim txuas ntxiv tau sau cia:
Los ntawm cov leeg musculoskeletal: mob sib koom tes (tsis tshua muaj).
Los ntawm cov leeg hlwb: polyneuropathy (tsis tshua muaj heev).
Los ntawm cov kab mob hepatobiliary: kab mob siab thiab mob daj ntseg (muaj tsawg).

Cov Yuav Tsum Muaj
· Cov kab mob siab nyob hauv cov theem nquag, suav nrog kev nce siab hauv qib ntawm qhov hloov pauv ntawm cov tsis paub lub hauv paus, nrog rau ib qho kev nce siab ntxiv ntawm transaminases nrog rau qib 3 zaug lossis siab dua qhov kev txwv siab dua ntawm cov cai,
Kev mob tsis zoo hauv lub raum nrog creatinine tshem tawm ≤30 ml / min,
Ib txhij siv cyclosporine,
Thaum cev xeeb tub thiab lactation,
Cov tshuaj tiv thaiv lub cev tsis muaj zog rau rosuvastatin lossis lwm yam ntawm Crestor,
Cov tshuaj tsis yog kws kho rau cov neeg mob uas tsis siv tshuaj kho kom zoo thiab siv tau txiaj ntsig,
Myopathy
· Ib koob tshuaj Crestor ntawm 40 mg / hnub yog contraindicated rau cov neeg mob uas muaj kev pheej hmoo ntawm rhabdomyolysis lossis myopathy,
· Muaj hnub nyoog txog 18 xyoo.

Cev xeeb tub
Tus ntoo khaub lig yog contraindicated rau kev siv hauv cov poj niam cev xeeb tub. Yog hais txog kev teem caij muaj ib leej niam, kev pub mis niam kom nres. Ua ntej kev kho mob nrog Krestor hauv cov poj niam ntawm lub hnub nyoog yug menyuam, nws yog qhov yuav tsum tau ua qhov kev ntsuas cev xeeb tub. Thaum noj cov tshuaj, nws yog ib qho tsim nyog los siv txoj hauv kev tswj kom tsis txhob muaj menyuam yaus.

Yeeb tshuaj sib cuam tshuam
Nrog rau kev siv tib lub sijhawm ntawm cyclosporine thiab rosuvastatin, AUC ntawm tom kawg yog kwv yees li 7 npaug ntau dua qhov ntsuas tib yam hauv cov neeg ua haujlwm noj qab haus huv. Kev siv ib txhij ntawm cov tshuaj no tsis hloov ntshav plasma concentration ntawm cyclosporine.
Thaum pib kho thiab thaum lub sijhawm nce ntxiv ntawm Crestor koob tshuaj, cov neeg mob uas tau txais warfarin thiab lwm cov tshuaj tiv thaiv vitamin K tib lub sijhawm, nrog rau lwm yam HMG-Co-A reductase inhibitors, tej zaum yuav muaj kev nce ntxiv hauv INR - International Li Qub piv - prothrombin lub sijhawm. Kev tshem tawm ntawm Krestor lossis txo nws qhov ntau npaum li cas ua rau INR poob qis. Thaum muab kev sib txuas nrog Crestor nrog vitamin K antagonists, saib xyuas ntawm INR (lub sijhawm prothrombin) yog kev pom zoo.
Kev siv cov tshuaj lipid-txo qis ib txhij (piv txwv li, hemifibrozil) thiab rosuvastatin ua rau kom qhov ntshav nce siab tshaj plaws ntawm rosuvastatin thiab nce nws AUC los ntawm 2 zaug.
Kev siv tib lub sijhawm ntawm ezetimibe thiab Krestor tsis ua rau muaj kev hloov pauv ntawm qhov ntshav siab tshaj plaws ntawm ob qho tshuaj, ib yam li AUC. Txawm li cas los xij, nws tsis pom zoo kom tsis suav lawv txoj kev sib txuam pharmacological nrog kev txhim kho kev mob tshwm sim.
Tsis muaj qhov chaw muag tshuaj sib xyaw nrog cov fibrates tau xav pom, tab sis pharmacodynamics zoo li muaj kev sib cuam tshuam. Hemofibrates, gemfibrozil, lwm cov fibrates thiab lipid-txo qis ntawm cov nicotinic acid (ntawm qhov koob tshuaj sib npaug rau 1 g / hnub lossis ntau dua) potentiate qhov kev pheej hmoo ntawm kev tsim myopathy thaum noj nws nrog HMG-CoA reductase inhibitors. Qhov no tej zaum vim qhov tseeb tias cov neeg sawv cev no ua rau muaj kev tshwm sim ntawm myopathy thaum lawv raug kho raws li kev kho mob monotherapy. Yog li ntawd, nrog kev sib xyaw ua ke no, nws pom zoo kom cov neeg mob ua ntej tshaj tawm ib koob tshuaj Krestor 5 mg / hnub.
Hauv kev sim tshuaj pharmacokinetic nyob rau hauv cov neeg tuaj yeem noj qab haus huv, kev sib xyaw ntawm Crestor thiab kev sib txuam ntawm ob lub cev tiv thaiv kab mob (100 mg ritonavour thiab 400 mg lopinavir) tau cuam tshuam nrog kwv yees li ntawm 2-npaug hauv AUC rau Crestor. Hauv qhov no, qhov siab tshaj plaws ntawm rosuvastatin tau nce ntau zog li 5 zaug. Kev sib cuam tshuam nrog lwm cov tshuaj tiv thaiv protease tau tsis tau kawm. Thaum muab tshuaj rau Krestor rau cov neeg muaj mob HIV uas siv ritonavir / lopinavir thaum siv Krestor, qhov feem yuav mob / cov txiaj ntsig yuav tsum raug txiav txim siab, tshwj xeeb tshaj yog thaum nce koob lossis pib kho.
Kev tswj hwm tib lub sijhawm ntawm erythromycin thiab rosuvastatin ua rau txo AUC ntawm rosuvastatin los ntawm 20% thiab nws cov ntshav siab tshaj plaws los ntawm 30%. Qhov kev sib txuam zoo sib xws muaj feem cuam tshuam nrog kev mob plab hnyuv vim yog siv erythromycin.
Cov kab mob tseem ceeb ntawm kev cuam tshuam ntawm antacids thiab Krestor tsis tau kawm. Kev siv ib txhij ntawm cov tshuaj antacids nrog rau kev sib xyaw ua ke ntawm kev sib xyaw ntawm magnesium hydroxide lossis aluminium thiab rosuvastatin ua rau kev poob qis hauv kev ua kom muaj zog ntawm cov tom kawg hauv cov ntshav ntshav los ntawm 50%. Yog tias cov tshuaj antacids tau noj 2 teev tom qab rosuvastatin, ces cov nyhuv no tsis tshua muaj suab.
Tsis xav sib cuam tshuam los ntawm kev sib tham nrog digoxin.
Kev siv tib lub sijhawm rosuvastatin thiab tshuaj noj hauv qhov ncauj ua rau nce AUC ntawm norgestrel thiab AUC ntawm ethinyl estradiol los ntawm 34% thiab 26%, feem. Yog li, nce ntxiv hauv plasma concentration yuav tsum raug txiav txim siab thaum noj tshuaj pov thaiv.Cov chaw muag tshuaj tsis sib xyaw ntawm Krestor thiab cov tshuaj rau kev hloov tshuaj hormone tsis tau kawm, tab sis kev cuam tshuam li no tsis tuaj yeem txiav txim siab tawm. Kev sib txuam zoo sib xws ntawm cov tshuaj tau siv dav thaum kuaj mob - txhua tus neeg mob zam nws zoo.
Cov txiaj ntsig ntawm txoj kev tshawb fawb txog kev sib cuam tshuam ntawm vivo thiab hauv vitro qhia tau hais tias cov tshuaj yeeb dej caw ntawm Krestor tsis yog qhov ua kom tsis muaj zog tsis yog qhov tsis txaus ntseeg ntawm cov enzymes ntawm cytochrome P450 system. Rosuvastatin tsuas yog lub cev tsis muaj zog rau kev nqis tes ua ntawm cov enzymes no. Tsis muaj kev cuam tshuam los ntawm kev mob sib kis ntawm ketoconazole (ib qho inhibitor ntawm CYP 3A4 thiab CY P 2A6) lossis fluconazole (ib qho inhibitor ntawm CYP 3A4 thiab CYP 2A9) thiab rosuvastatin. Kev tswj hwm tib lub sij hawm ntawm itraconazole (ib qho CY P3A4 inhibitor) thiab rosuvastatin nce AUC ntawm qhov kawg ntawm 28%, uas tsis muaj qhov tseem ceeb hauv kev kho mob. Yog li no, kev sib cuam tshuam cuam tshuam nrog cov metabolism ntawm cytochrome P450 tsis xav.

Noj ntau dhau
Yog tias qhov koob tshuaj tau tshaj dhau, qhov kev kho mob tshwj xeeb tseem tsis tau txhim kho. Cov tsos mob uas sawv cev thiab cov kev pab txhawb nqa tau siv. Yog tias qhov kev noj tshuaj ntau dua, nws yog ib qho tsim nyog los tswj lub siab ua haujlwm thiab cov ntsiab lus ntawm creatine phosphoskinase (CPK). Qhov ua tau zoo ntawm hemodialysis yog qhov tsis zoo.

Daim ntawv tso tawm
Cov ntsiav tshuaj ntawm 10, 20, 40 mg. Muaj 28 ntsiav tshuaj nyob hauv ib lub hlwv.

Cia rau cov neeg mob
Khaws ntawm qhov kub tsis tshaj li 30 ° C. Khaws tsis ncav cuag ntawm cov menyuam yaus. Tso tawm los ntawm kev kho mob.

Muaj pes tsawg leeg
Crestor 10 mg
Cov khoom xyaw dhia: rosuvastatin 10 mg.

Crestor 20 mg
Cov khoom xyaw nquag: rosuvastatin 20 mg.
Cov tshuaj tsis muaj zog: lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, hlau oxide liab (E 172), titanium dioxide, dej lim.

Crestor 40 mg
Cov khoom xyaw nquag: rosuvastatin 40 mg.
Cov tshuaj tsis muaj zog: lactose monohydrate, microcrystalline cellulose, calcium phosphate, magnesium stearate, crospovidone, glycerol triacetate, hypromellose, hlau oxide liab (E 172), titanium dioxide, dej lim.

Pharmacological pawg
Tshuaj mob plawv
Antisclerotic tshuaj

Yam tshuaj muaj sia: Rosuvastatin

Yeem
Nrog rau kev pheej hmoo ntawm kev txhim kho myopathy lossis rhabdomyolysis, nws yog ib qho tsim nyog yuav tsum coj mus rau tus lej ntawm cov txiaj ntsig ntawm kev kho mob thiab kev pheej hmoo, cov neeg mob zoo li no yuav tsum tau ua tib zoo saib xyuas mob. Hauv kev tshwm sim uas qib ntawm CPK nce siab (5 zaug lossis ntau dua) txawm tias ua ntej kev kho mob, rosuvastatin yuav tsum tsis txhob noj. Kev txiav txim ntawm cretin phosphokinase los tswj txoj kev txhim kho ntawm rhabdomyolysis los yog myopathy yog qhov tsis tsim nyog los ua nyob rau ntawm lwm qhov tshwm sim rau kev nce qib hauv CPK lossis tom qab kev tawm dag zog lub cev, vim qhov no tuaj yeem pab txhawb kev txhais tsis raug. Yog tias thawj cov ntsiab lus ntawm creatine phosphokinase tau nce 5 zaug lossis ntau dua, kev txiav txim siab tom ntej ntawm cov enzyme hauv cov ntshav cov ntshav yuav tsum tau ua kom tsis pub tsawg dua 5 (ntau kawg - 7) hnub. Koj yuav tsum tsis txhob pib kho nrog Crestor yog tias kev txiav txim siab zaum thib ob qhia tau theem pib siab ntawm creatine phosphokinase (5 zaug ntau dua li qhov kev txwv sab sauv ntawm ib txwm).
Crestor, zoo ib yam li lwm yam HMG-CoA reductase inhibitors, yuav tsum tau muab kev coj ua nrog ceev faj rau cov neeg mob uas muaj lub siab xav ua tus mob myopathy / rhabdomyolysis. Cov teeb meem pheej hmoo rau rhabdomyolysis lossis myopathy tuaj yeem yog: hypothyroidism, lub raum tsis ua haujlwm, cov xwm txheej uas ua rau muaj ntshav ntau ntxiv ntawm rosuvastatin, kev haus cawv ntau, muaj hnub nyoog dhau 70 xyoo, muaj cov kab mob nqaij mob hauv tsev neeg lossis cov keeb kwm, myotoxicity provoked los ntawm kev siv ntawm lwm cov nqaij lossis ntshav lossis tshuaj tiv thaiv MMC-inhibitors. Keeb kwm ntawm CoA reductase, concomitant siv ntawm fibrates.
Yog tias Krestor tau sau ntawv rau tus neeg mob, lawv yuav tsum qhia nws txoj cai tam sim ntawd rau tus kws kho mob uas tau koom nrog txhua tus neeg mob tsis nco qab txog cov leeg tsis muaj zog, mob leeg nqaij lossis mob plab, tshwj xeeb yog lawv nrog kub taub hau thiab malaise. Hauv cov neeg mob no, kev txiav txim siab txog theem ntawm creatine phosphokinase (CPK) yog qhov yuav tsum tau ua. Txais tos ntawm Krestor yuav tsum nres yog tias cov ntsiab lus ntawm CPK tau nce ntau (5 zaug lossis ntau dua), lossis nrog qhov mob hnyav ntawm cov leeg mob uas ua rau muaj kev tsis nco qab nyob rau txhua hnub txawm tias lub ntsiab lus ntawm creatine phosphokinase tsis ncav 5-nce ntxiv. Yog tias cov tsos mob ploj thiab CPK cov ntsiab lus rov rau nws cov txiaj ntsig tseem ceeb, xav txog txoj kev rov ua dua lwm qhov HMG-CoA reductase lossis Crestor inhibitors hauv cov koob tshuaj qis dua qhov qub. Xws li tus neeg mob xav tau kev saib xyuas mob nkeeg kom zoo. Kev soj ntsuam lub sijhawm tsis tu ncua ntawm CPK nyob rau hauv qhov tsis muaj cim ntawm rhabdomyolysis lossis myopathy tsis muaj zog.
Tsis muaj cov cim ntawm kev nce ntxiv hauv Crestor cov nyhuv ntawm cov pob txha pob txha thaum lub sijhawm sim kho nrog qhov kev kho kom zoo. Txawm li cas los xij, muaj ntawv tshaj tawm txog kev nce ntxiv ntawm qhov tshwm sim ntawm myopathy thiab myositis nyob rau hauv cov neeg mob uas coj lwm yam HMG-CoA reductase inhibitors nrog fibrin acid derivatives (suav nrog kev siv tshuaj xws li nicotinic acid, gemfibrozil, cyclosporine, inhibitors) proteases, azole tshuaj tua kabmob thiab cov tshuaj tua kabmob macrolide). Gemfibrozil tsub kom muaj kev pheej hmoo ntawm myopathy nrog kev sib txuam ntawm Crestor thiab qee qhov inhibitors ntawm HMG-CoA reductase. Nws tsis pom zoo kom sau ntawv Krestor thiab gemfibrozil tib lub sijhawm. Nws yog ib qho tsim nyog yuav tsum tau ua tib zoo ntsuas tus piv ntawm cov txiaj ntsig zoo li cas thiab muaj kev pheej hmoo thaum sau ntawv sib xyaw ntawm niacin, fibrates thiab Crestor.
Concomitant tswj nrog Krestor fibrates nyob rau hauv ib koob ntawm 40 mg yog contraindicated.
Krestor tsis pom zoo rau cov neeg mob uas muaj mob hnyav (piv txwv li, nrog txoj hlab ntshav ntawm txoj hlab ntaws, kev poob plig, mob sepsis, thaum muaj kev phais mob ntxiv, tshaj tawm hais txog endocrine, metabolic lossis electrolyte cuam tshuam, nrog rau thaum tsis muaj kev tswj hwm tus mob vwm, vim tias cov mob no tuaj yeem dhau los ua kev pheej hmoo rau rhabdomyolysis / myopathy).
Hauv cov neeg mob uas siv cov tshuaj rosuvastatin hauv kev txhaj tshuaj ntau (feem ntau ntawm kev noj tshuaj 40 mg / hnub), muaj qee zaum muaj tubular proteinuria. Tubular proteinuria tau kawm ib ntus los yog hloov nyob rau hauv feem ntau. Cov proteinuria no tsis yog qhov pov thawj ntawm kev loj hlob ntawm cov mob raum sai lossis kev loj hlob ntawm ib qho uas twb muaj lawm. Cov neeg mob tau txais Krestor ntawm thaj chaw 40 mg / hnub, nws raug nquahu kom saib xyuas lub sijhawm tsis zoo ntawm lub raum thaum txais tos ntawm Krestor (tag nrho chav qhia txog txoj kev kho).
Thaum noj rosuvastatin, tshwj xeeb tshaj yog siv li ntawm 20 mg / hnub, tau tshaj tawm cov teebmeem ntawm cov leeg pob txha, xws li mob leeg, mob rhabdomyolysis, lossis myopathy. Txawm li cas los xij, nrog kev sib xyaw ntawm ezetimibe thiab HMG-CoA reductase inhibitors, rhabdomyolysis tsim nyob hauv qee qhov xwm txheej tsawg.
Kev nyab xeeb thiab ua tau zoo ntawm kev siv Krestor hauv menyuam yaus tseem tsis tau tsim. Hauv kev xyaum ua pediatric, qhov kev paub ntawm kev siv rosulostatin tsuas pub tsawg tsawg ntawm kev soj ntsuam (cov menyuam yaus hnub nyoog qis dua 8 xyoo thiab laus dua nyob hauv homozygous tsev neeg hypercholesterolemia). Yog li, nws tsis pom zoo kom siv Krestor rau kev kho mob hauv kev kho cov menyuam yaus.

Txhua yam lus tau hais tawm rau kev qhia tawm thiab tsis yog lub laj thawj ntawm kev kho tus kheej lossis hloov cov tshuaj.

Koj tuaj yeem xav zoo nyob hauv koj lub neej tsis xws luag, thiab tom qab soj ntsuam, kawm txog hyperlipidemia - cov ntsiab lus ntawm cov roj cholesterol thiab triglycerides hauv cov ntshav.Kev mob asymptomatic ua rau muaj kev pheej hmoo loj ntawm cov quav txaij atherosclerotic plaques - cov kev xav ua ntej ntawm kev mob plawv thiab mob nkees.

Krestor, ib qho tshuaj zoo ntawm cov cim tshiab, tsim los ua kom cov lipid metabolism zoo li qub, yuav pab tiv thaiv kev phom sij.

Pharmacological tau

Crestor yog ib qho lipid-txo cov tshuaj tsim rau kev tiv thaiv thiab kho ntawm atherosclerosis. Rosuvastatin, lub ntsiab lus nquag ua haujlwm, muaj cov nyhuv hypocholesterolemic thiab hypolipidemic.

Krestor inhibits HMG-CoA reductase, ib qho enzyme uas tswj kev tsim cov mevalonate, cov roj cholesterol ua ntej. Rosuvastatin ua haujlwm nyob rau hauv daim siab - ib qho ntawm lub ntsiab hom kabmob.

Statin txo cov lipoproteins ntau nrog qhov tsawg thiab tsis tshua muaj siab los ntawm kev txwv lawv cov synthesis, ntxiv rau txhim kho HDL ntxiv rau kom sib luag thiab catabolism ntawm LDL. Raws li qhov tshwm sim, qib ntawm cov roj (cholesterol) tag nrho, LDL thiab triglycerides tsawg dua. Nyob rau tib lub sijhawm, qhov concentration ntawm HDL nce.

Rosuvastatin ua tau zoo rau hypercholesterolemia hauv kev sib xyaw nrog lossis tsis muaj hypertriglyceridemia, rau cov neeg mob uas tsis hais poj niam txiv neej, hnub nyoog thiab haiv neeg.

Cov txiaj ntsig ntawm kev siv Krestor, kev txiav txim siab los ntawm cov lus tawm tswv yim los ntawm cov neeg koom nrog kev tshawb fawb, raug pom los ntawm qhov kawg ntawm thawj lub lim tiam ntawm qhov kev kawm, tab sis qhov tshwm sim siab tshaj (dhau 90%) tuaj yeem pom tsuas yog tom qab 2-4 lub lim tiam ntawm kev siv tas li.

Tsis zoo li qee qhov analogues, Krestor muaj qhov tsawg kawg ntawm qhov tsis zoo ntawm daim siab. Siv nws ua ke nrog kev noj zaub mov roj kom tsawg thiab lwm yam tshuaj noj kom txo cov roj cholesterol.

Dab tsi ua kws kho mob thiab cov neeg mob xav txog Crestor

Txog Krestor, kev tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob sib luag: tshuaj yog ib qho ua tau zoo, muaj kev tiv thaiv zoo. Cov kws kho mob nco ntsoov cov pov thawj loj thiab cov kev paub ntawm tus kheej ntawm kev vam meej kev siv rosuvastatin.

Dovgopolov I.K., kws kho plawv, kev sib tw ntawm kev kawm kho mob Rau ib hlis lossis ob zaug, Kuv tsis tau hais kom Krestor lossis nws hloov cov duab hloov pauv, txawm hais tias rau kev tiv thaiv. Koj tuaj yeem tuaj yeem ntxuav cov hlab ntsha thiab tsis pub dawb los ntawm cov plahaum roj hauv ob xyoos, thiab qhov no ntawm kev siv ntau kawg (40 mg / hnub).
Yog tias cov peev nyiaj tso cai, nws zoo dua los yuav cov tshuaj qub. Thawj qhov tshiab ntawm rosuvastatin yog Krestor, nws yog rau nws tias kev sim tau nqa nrog kev ntsuas kev tuag ntawm cov kab mob plawv. Rau cov generics, tsis muaj cov ntaub ntawv zoo li no, tab sis ib qho khoom plig zoo yuav tsum muaj los txhim kho lipid profile, txawm hais tias tsis tau ua li ntawd. Kuv yuav tsum tau hais tias statins tsis raug coj los txo qis LDL, tab sis txhawm rau tiv thaiv cov hlab ntsha tawg thiab plawv nres. Kev siv lub neej muaj sia yuav tsum tau siv mus txuas ntxiv.

Korolenko V.N., kws kho mob hlwb. Krestor ceev txoj kev lipid metabolism sai txawm tias tsis muaj koob. Cov ntaub ntawv pov thawj ntawm thawj cov tshuaj yog qhov zoo, muaj cov kev mob tshwm sim tsawg dua li lwm cov statins, yog li kuv tuaj yeem muaj kev nyab xeeb los kho nws txawm tias cov neeg mob uas muaj kab mob xws li mob ntshav qab zib mellitus lossis tsev neeg hypercholesterolemia. Tus nqi rau Krestor, tau kawg, yog qhov zoo heev, tab sis tej zaum qhov no tsuas yog nws qhov tsis zoo xwb, tshwj xeeb tshaj yog txij li kev siv tshuaj ntawm cov qib no tsis tuaj yeem pheej yig.

Marina, Voskresensk. Krestor yog ob peb zaug kim kim dua li nws cov counterparts, txhawm rau kom txuag nyiaj Kuv yuav tsum tau yuav ib pob loj, tab sis rau kuv tus kheej Kuv tsis pom lwm txoj kev xaiv. Kuv tau noj statin rau ntau tshaj ib xyoos, yog li kuv tuaj yeem txiav txim siab nws ua haujlwm tau. Cov kws kho mob zoo siab nrog kuv daim lipid profile. Nws ntseeg tias Krestor yog cov tshuaj zoo tshaj plaws ntawm pawg no. Kuv tsis saib tej kev mob tshwm sim.

Oleg, Irkutsk. Kuv lub plawv nres tau ua rau kuv xav tsis thoob thiab ua rau kuv xav txog kuv txoj kev noj qab haus huv. Nqa mus rau qhov chaw dhia ua si, sim txiav luam yeeb. Tus kws kho mob tau sau ntawv tseg rau kev noj haus thiab Crestor. Kuv haus tsuas yog ob lub hlis, Kuv tsis paub - los ntawm cov tshuaj los yog cov chav kawm nrog tus kws qhia, tab sis tam sim no cov roj (cholesterol) yuav luag zoo dua - 5.8. Kuv tsis xav cia siab rau cov tshuaj hauv kuv lub neej, yog li kuv sim ua lub neej tshiab rau kuv.

Koj tuaj yeem kawm txog Asmeskas kev paub txog kev siv Krestor los ntawm "Kev Siv Tshuaj Rau Cov Neeg Noj Qab Nyob Zoo".

Cov tshuaj ntawm cov tshuaj Krestor, uas nws cov analogues yog cov sawv cev dav hauv lub tsev muag tshuaj network, yog tsim nyog los txo cov ntshav hauv cov ntshav siab. Cov kev kho mob zoo yuav pom tau tom qab 7 hnub txij li hnub pib. Nyob rau lub lim tiam tom ntej, cov tshuaj yuav luag 2 zaug txo qhov kev tswj hwm ntawm cov cholesterol. Vim muaj ntau yam tshwm sim, cov tshuaj qub tsis tuaj yeem siv tas mus li, qhov no, siv cov tshuaj tsis sib xws (analog).

Ib qho loj ntawm cov tshuaj tua kab mob

Ua ntej yuav sau ntawv yuav tshuaj, koj yuav tsum ua qhov kev kuaj mob. Nws lub hom phiaj yog txiav txim siab lub cev ntawm lub cev. Yog tias qhov kev xav tau tsim nyog tshwm sim, ib qho ntawm cov tshuaj hauv qab no tuaj yeem hloov cov khoom qub:

Tus neeg mob muaj txoj hauv kev los xaiv cov tshuaj pheej yig uas tsis qis dua hauv lawv qhov ntsuas rau qhov tshuaj tseem ceeb. Nws yuav tsum nco ntsoov tias qhov ntau npaum li cas thiab kev siv ntev npaum li cas txiav txim siab tsuas yog tus kws kho mob tsuas yog siv raws cov kev ntsuas pom. Cov no suav nrog kev tiv thaiv thiab kho kab mob atherosclerosis thiab ntshav siab cov roj.

Qhov ntau npaum cov tau xaiv nrog cov hniav nyiaj hniav kub qhov tseeb yuav pab kom tau txais txiaj ntsig zoo. Tus kws kho mob yuav tsum txiav txim siab ntau npaum li cas ntawm cov tshuaj nrog kev saib xyuas tshwj xeeb thaum tus neeg mob nyuam qhuav mob stroke lossis lub plawv nres. Yog tias tus neeg raug kuaj pom tias muaj tus mob hypercholesterolemia - hloov kho cov ntshav roj hauv cov ntshav muaj roj, nws yog qhov yuav tsum tau siv txoj hauv kev nyuaj.

Tus thawj cov tshuaj thiab nws cov hloov pauv tau feem ntau yog ib feem ntawm kev noj haus. Piv txwv li, tus kws kho mob pom zoo txo ​​qhov hnyav hauv lub cev. Hauv qhov no, koj tuaj yeem siv tus neeg sawv cev ntawm Lavxias. Peb tab tom tham txog cov tshuaj Martinil, Ariescor thiab Simvastin. Cov lus qhia zoo sib xws tsuas yog qhia ncaj qha thaum tus neeg mob kuaj mob ntshav qab zib.

Qhov ntau thiab cov tshuaj yog xaiv kom qhov qis roj tsis txhawm rau kev phiv.

Cov yam ntxwv ntawm kev siv tshuaj

Cov kab mob ntawm daim siab thiab ob lub raum yog qhov tseem ceeb tshaj plaws uas yuav tsum tau muab xav kom txhawm rau txhawm rau kho kom zoo. Vim tias qhov tseeb ntawm cov tshuaj analogues muaj cov tshuaj uas nyob rau hauv ib txoj kev cuam tshuam cov hlwb ntawm lub cev hematopoietic, tus kws kho mob yuav tsum soj ntsuam cov txiaj ntsig ob peb zaug. Ntawm ib sab tes, nws yog ib qho tsim nyog yuav tsum ua kom txoj haujlwm ntawm cov hlab ntshav sai li sai tau. Ntev npaum li lawv tau daig nrog cov plahaum roj av, nws yuav nyuaj rau ntshav kis taug kev thoob plaws lub cev.

Ntawm qhov tod tes, koj yuav tsum coj mus rau hauv tus account puab ntawm lub siab. Yog tias kev tiv thaiv txoj hauv kev no, nws raug nquahu kom xaiv cov koob tshuaj tsawg kawg nkaus - tsis pub ntau tshaj 25 g ntawm cov khoom nruab hnub. Tus kws kho mob thoob plaws hauv chav kawm ntawm kev kho mob saib xyuas tus neeg mob txoj kev noj qab haus huv. Ib qho kev saib xyuas zoo sib xws yuav pab tau yog tias tus neeg mob lub cev tsis ua haujlwm hauv lub raum.

Kev txheeb xyuas ua ntej yuav pab kom tsis txhob ua mob. Raws li cov txiaj ntsig tau, ib txoj kev xaus yog kos ntawm qhov ua tau los siv cov tshuaj. Ntawm lwm qhov kev pheej hmoo, cov kws kho mob cais cov neeg mob lub hnub nyoog, muaj cov kab mob ntev ntev, yav dhau los siv tshuaj thiab tus lej ntawm tus yam ntxwv.

Ceev faj

Ua ntej pib txoj kev kho mob hauv chav kawm, tus kws kho mob yuav tsum kuaj xyuas seb puas pom cov khoom noj sib ntxiv lossis cov khoom qub tau nyab xeeb rau ib tus neeg mob. Nws tsis pom zoo kom taw nws rau lub cev xeeb tub thiab lactating niam. Nws yog qhov zoo dua los xaiv Krestor analogues nrog kev ua haujlwm siab, lub siab ua haujlwm tsis txaus, yog tias tus neeg mob hnub nyoog qis dua 18 xyoo.

Siv cov tshuaj analog lossis cov tshuaj tseem ceeb nrog cov roj (cholesterol) yuav tsis muaj kev nyab xeeb tas li. Txawm hais tias tus kws kho mob soj ntsuam txhua txoj kev ceev faj, nws muaj peev xwm muaj kev phiv:

• cov tsos mob ntshav qab zib
• mob taub hau thiab mob taub hau
• bouts ntawm xeev siab
• mob plab ua hauj lwm
• zawv plab
• cem quav
• kiv taub hau
• urticaria
• xoo pob thiab khaus
• txog siav.

Kev siv cov tshuaj tseem ceeb thiab cov tshuaj noj mob pub rau tom qab tuaj ntsib kws kho mob hauv chaw ua haujlwm. Tus kws kho mob yuav ua qhov kev kuaj mob thiab sau ntawv rau qhov kev kuaj mob tsim nyog. Raws li cov ntaub ntawv tau sau, kev tshuaj ntsuam xyuas kev noj qab haus huv tau ua. Tom qab qhov no, txoj kev kho kom haum thiab lub sijhawm ua haujlwm tau txiav txim. Qhov ntau dua qhov ua kom tus neeg mob ua tiav cov lus pom zoo, ua kom rov zoo dua.