Vasonite: tshuaj xyuas, analogues, cov lus qhia rau kev siv

Yog cov tshuaj zoo li Wazonite 600 ua tau zoo? Koj tuaj yeem pom kev tshuaj xyuas txog cov tshuaj no me ntsis txuas ntxiv. Tsis tas li, cov ntaub ntawv ntawm tsab xov xwm no muab cov lus qhia txog yuav ua li cas noj cov tshuaj no, nyob rau hauv rooj plaub twg nws yog tshuaj, thiab nyob rau hauv uas nws txwv tsis pub.

Kev sib xyaw thiab duab

Daim ntawv sau cov tshuaj "Vazonit" yog dab tsi? Kev txheeb xyuas pom tau hais tias qhov kev kho no tuaj yeem muas tau yog hom elongated dawb thiab biconvex ntsiav tshuaj nrog kev pheej hmoo ntawm ob sab. Lawv muaj lub caij nyoog ntev, nrog rau zaj duab xis-txheej thiab muab tso rau hauv cov hlwv uas muaj nyob hauv cov duab los qhia.

Cov tshuaj sib xyaw ua ke hauv kev txiav txim siab suav nrog pentoxifylline (cov tshuaj ua kom muaj zog) thiab cov khoom siv pabcuam xws li crospovidone, hypromellose 15000 cP, colloidal silicon dioxide, microcrystalline cellulose thiab magnesium stearate.

Raws li rau lub plhaub ntsiav tshuaj (zaj duab xis), nws muaj macrogol 6000, talc, titanium dioxide, 5 cP hypromellose thiab polyacrylic acid nyob rau hauv daim ntawv ntawm 30% dispersion.

Pharmacological kev txiav txim

Vazonit® txhim kho microcirculation thiab rheological zog ntawm cov ntshav, muaj cov nyhuv vasodilating. Nws muaj pentoxifylline, ib qho xanthine derivative, ua cov tshuaj nquag. Lub tshuab ntawm kev ua yog txuam nrog kev txwv tsis pub phosphodiesterase thiab kev txuam nrog cAMP hauv cov leeg nqaij mos ntawm cov hlab ntsha, hauv cov khoom tsim ua kom ntshav, hauv lwm cov nqaij thiab cov plab hnyuv siab raum. Cov tshuaj inhibits kev sib sau ntawm platelets thiab cov ntshav liab, ua rau lawv cov elasticity, txo qib fibrinogen hauv cov ntshav plasma thiab ua kom cov fibrinolysis, uas txo cov viscosity ntawm cov ntshav thiab txhim kho nws cov rheological. Nws txhim kho cov ntaub so ntswg oxygen muab rau hauv thaj chaw ntawm qhov tsis muaj zog, tshwj xeeb tshaj yog nyob rau ntawm cov nqua, cov hlab ntsha hauv nruab nrab, thiab, kom tsis muaj qis dua, hauv lub raum. Tsawg me ntsis dilates cov hlab ntshav hlab ntsha.

Kws Tshuaj

Cov tshuaj yog dab tsi zoo li Wazonite 600? Kev tshuaj xyuas ntawm cov kws kho mob tau hais tias cov cuab yeej no muaj peev xwm muab cov kev coj ua hauv qab no:

tiv thaiv cov phab ntsa ntawm cov hlab ntsha los ntawm cov kev tsis zoo (uas yog, muaj cov nyhuv angioprotective),
txhim kho cov ntshav microcirculation nyob rau hauv cov chaw ntawm cov ntshav tsis txaus (vim yog txhim kho rheological zog ntawm cov ntshav, lossis lub npe hu ua fluidity),
tiv thaiv kom tsis txhob mob thrombosis (i.e. muaj cov txiaj ntsig antiaggregatory),
txhawm rau so cov leeg leeg ntawm cov hlab ntsa (qhov ntawd yog, muaj cov nyhuv vasodilating),
muab cov ntaub so ntswg nrog oxygen.

Cov Tshuaj Pharmacokinetics

Kev noj tshuaj ntawm cov ntsiav tshuaj Wazonit® retard sab hauv muab ib qho kev tso tawm tas mus li ntawm cov tshuaj muaj yees thiab nws txoj kev nqus ntawm kev mob plab. Cov tshuaj undergoes metabolism hauv lub siab thaum lub sijhawm "thawj pass", vim li ntawd cov lej ntawm cov tshuaj pharmacologically nquag metabolites tau tsim. Qhov siab tshaj plaws ntawm pentoxifylline thiab nws cov nquag metabolites hauv ntshav tau mus txog tom qab 3-4 teev thiab tseem nyob rau qhov kho tshuaj rau 12 teev. Cov tshuaj tawm hauv cov zis tawm hauv cov zis hauv daim ntawv ntawm metabolites.

Kev ntsuas rau siv

- Kev mob sib txawv (obliterating endarteritis, mob ntshav qab zib angiopathy, Raynaud's mob)

- Kev cuam tshuam ntawm lub hlwb ncig ntawm lub ischemic hom (ischemic cerebral stroke)

- Atherosclerotic thiab dyscirculatory encephalopathy, angioneuropathy

- Cov ntaub so ntswg hloov pauv vim yog ua tsis taus txoj hlab ntshav lossis cov hlab ntsha ua kom muaj ntshav (mob tom qab mob ntshav qab zib, cov leeg ntshav, mob leeg, trophic mob txhab, mob caj dab, ua pa tsw qab)

- Kev mob tsis zoo ntawm lub qhov muag (mob, raug mob thiab mob ntshav qab zib tsis ua hauj lwm hauv qhov muag tsis pom qab los yog choroid)

- Hnov hnov lus tsis zoo vascular keeb kwm, nrog hnov lus tsis zoo.

Tsuas tshuaj thiab tswj hwm

Lub sijhawm ua haujlwm ntawm kev kho thiab qhov ntau npaum li cas yog suav los ntawm tus kws kho mob ib leeg zuj zus, nyob ntawm qhov chaw kuaj mob ntawm cov kab mob thiab cov txiaj ntsig kho kom zoo.

Cov ntsiav tshuaj Wazonit® retard yuav tsum noj qhov ncauj tom qab noj mov, tsis tas yuav zom thiab haus dej kom ntau.

Cov tshuaj feem ntau tau sau 1 ntsiav tshuaj 2 zaug hauv ib hnub (yav sawv ntxov thiab yav tsaus ntuj).

Sab sij huam

Cov ntsiav tshuaj Wazonit® retard yuav tsum noj qhov ncauj tom qab noj mov, tsis tas yuav zom thiab haus dej kom ntau.

Cov tshuaj feem ntau tau sau 1 ntsiav tshuaj 2 zaug hauv ib hnub (yav sawv ntxov thiab yav tsaus ntuj).

Daim ntawv thov nta

muaj peev xwm orthostatic hypotension, nrog rau cov mob txha caj qaum mob heev thiab cov hlab ntsha atherosclerosis nrog rau cov hlab ntsha tawg, cov neeg mob plawv tsis ua haujlwm, mob plawv dhia tsis ua haujlwm, nrog kev mob txhab rau hauv lub plab, cov neeg mob ua rau mob phais (mob ntshav tawm), nrog lub raum tsis ua haujlwm. Pom zoo ntsuas ntshav siab thiab ntshav siab yog qhov pom zoo.

Mechanism ntawm kev ua

Cov txiaj ntsig zoo ntawm cov tshuaj "Wazonit 600" yog dab tsi raws li? Cov kev txheeb xyuas tau hais tias cov tshuaj tiv thaiv tseem ceeb ntawm cov tshuaj no muaj peev xwm txhim kho cov ntshav hauv cov hlab ntsha me thiab hauv cov chaw uas nws tsis txaus. Tus txheej txheem no tshwm sim vim txhim kho cov ntshav txaus, nrog rau kev nthuav cov hlab ntsha me.

Raws li cov kws tshaj lij, cov ntshav tau nce ntxiv vim yog rov kho dua li qub ntawm cov platelets thiab cov qe ntshav liab, nrog rau kev tawm tsam ntawm txoj kev sib khi, tom qab los ntawm kev tsim cov ntshav txhaws.

Cov tshuaj "Vazonit" yuav ua li cas? Kev xyuas rov hais tias tom qab noj cov tshuaj no hauv cov ntshav, qib protein ntau txo tsawg. Los ntawm txoj kev, nws yog lub caij kawg uas koom nrog kev tsim cov ntshav txhaws, thiab tseem txhim kho cov fibrinolysis, uas yog, daws cov kab mob uas sawv ua ke. Nws yuav tsum raug sau tseg tias nthuav tawm ntawm cov hlab ntsha tuaj yeem txhim kho cov ntshav ncig ntawm txhua cov ntaub so ntswg.

Cov yam ntxwv ntawm cov tshuaj noj

Lub txiaj ntsig zoo li cas yog txhais tau tias "Vazonit" (ntsiav tshuaj)? Cov kev tshuaj xyuas tau tshaj tawm tias los ntawm kev muab cov ntaub so ntswg nrog cov pa oxygen, cov tshuaj no pab txhawb kev txhim kho cov roj metabolism hauv lub cev, nrog rau kev rov ua haujlwm ntawm kev ua haujlwm ntawm txhua lub nruab nrog cev thiab cov kab ke.

Raws li koj paub, nrog ib qho kev txo qis ntawm patency ntawm cov hlab ntsha hauv cov leeg, uas tshwm sim, piv txwv li, hauv cov txheej txheem ntawm kev tsim mob atherosclerosis, txhim kho cov ntshav kev nyob hauv cov ceg tawv pab kom tus neeg mob taug kev yooj yim dua. Tsis tas li, nws spasms ntawm plab hlaub cov leeg txo qis lossis ploj tag nrho.

Puas yog cov tshuaj "Vasonit" nqus rau hauv cov hlab ntshav? Cov lus qhia, tshuaj xyuas tau lees tias tom qab noj tshuaj hauv ncoo sab hauv, nws txoj haujlwm nquag yog maj thiab yuav luag tag nrho los ntawm lub plab zom mov. Nyob rau tib lub sijhawm, nws muab txoj kev cuam tshuam ntev ntawm cov tshuaj.

Tom qab kev nqus, pentoxifylline yauv yauv pauv cov pa metabolism hauv lub siab, uas ua rau muaj kev tsim tshuaj pharmacologically nquag plias cov khoom lag luam. Lawv cov kev xav ntau tshaj plaws hauv cov kab ke hauv ntiaj teb tau mus txog tom qab 4 teev, thiab cov txiaj ntsig kho tau ntev rau ib nrab hnub.

Cov tshuaj hauv cov lus nug yog tawm hauv cov zis hauv daim ntawv ntawm cov khoom lag luam metabolic. Tsis tas li, qee cov tshuaj tuaj yeem tawm hauv niam mis thiab tso quav.

Hauv kev mob raum tsis zoo, pentoxifylline ua rau qeeb dua. Qhov no yuav tsum txo qis hauv lub koob tshuaj. Nrog rau daim siab ua haujlwm tsis zoo, tus neeg mob nce lub bioavailability ntawm cov tshuaj, uas tseem xav tau kev tshuaj xyuas ntawm cov qauv txheej txheem txoj kev kho.

Cov kab mob dab tsi puas "Vazonit" tshuaj uas muaj txiaj ntsig zoo tshaj plaws hauv nws tus kheej? Kev tshuaj xyuas cov neeg mob hais tias qhov cuab yeej no tau pab lawv tau zoo hauv qab no:

kev cuam tshuam ntawm cov ntshav ncig ntawm lub paj hlwb cuam tshuam nrog nws cov kev tsis txaus₂, as Well as kev hloov pauv ntawm vascular patency,
arterial circulatory ntshawv siab cuam tshuam nrog kev mob atherosclerosis, mob rau sab hauv phab ntsa ntawm cov hlab ntshav, ntshav qab zib mellitus, Raynaud tus kab mob, nrog rau tiv thaiv keeb kwm ntawm gangrene thiab frostbite,
raws li ib feem ntawm kev sib txuas ua ke rau kev cuam tshuam ntawm ischemic stroke, uas nrog los ntawm kev tsis hnov zoo ntawm kev saib xyuas thiab txawj ntse,
kev cuam tshuam ntawm cov ntshav ncig mus tawm tsam keeb kwm ntawm thrombophlebitis, varicose leeg thiab tsim cov leeg mob rau tom qab,
metabolic thiab dystrophic mob ntawm lub hlwb,
hnov thiab pom kev tsis zoo cuam tshuam txog kev ncig tsis zoo hauv cov chaw no.

Txwv tsis pub nkag

Nyob rau hauv qhov xwm txheej dab tsi nws txwv tsis pub noj tshuaj Vazonit? Kev txheeb xyuas qhia cov nram qab no contraindications:

myocardial infarction hauv lub sijhawm mob,
tsis pom kev zoo, uas yog txuam nrog hemorrhages,
ntshav roj hauv lub hlwb (i.e. nrog hemorrhagic mob stroke),
muaj los ntshav tseem ceeb
cev xeeb tub thiab lactation
muaj hnub nyoog me
kev tsis qaug rau lub zog ntawm cov tshuaj.

Xyuam xim teem caij

Nrog rau qhov ceev faj, cov ntsiav tshuaj nyob rau hauv nqe lus nug yog kho rau atherosclerosis ntawm cov hlab ntsha ntawm lub plawv thiab lub hlwb, ntshav siab tsis txaus, lub plawv tsis xwm yeem, cuam tshuam hauv cov hlab ntsha hauv lub plab, lub raum thiab mob siab, hauv lub sijhawm postoperative, nrog lub plab hnyuv, ua kom ntshav tawm, nrog rau lub hnub nyoog laus.

Cov ntsiav tshuaj "Vazonit": cov lus qhia rau kev siv

Kev tshuaj xyuas ntawm cov kws tshaj lij tau tshaj tawm tias cov tshuaj no muaj txiaj ntsig zoo tsuas yog tias nws tau ua raws li kev pom zoo los ntawm tus kws kho mob lossis qhia. Raws li tom kawg, cov tshuaj hauv nqe lus nug yuav tsum tau noj 600 mg ob zaug ib hnub tom qab noj mov, ntxuav nrog dej thiab tsis ntxo.

Rau cov tib neeg mob, qhov ntau npaum li cas ntawm cov tshuaj, nrog rau lub sijhawm ntawm nws cov kev tswj hwm, tau xaiv ib tus zuj zus.

Tam sim no koj paub yuav tsum noj tshuaj "Vazonit" li cas. Ntev npaum li cas los haus nrog thromboangiitis? Cov kev txheeb xyuas tau hais tias lub sijhawm ntev ntawm kev kho mob, nrog rau kev noj tshuaj ntau dua rau qhov mob ntawd, yog tus kws kho mob tshwj xeeb, nyob ntawm thaj chaw kho mob thiab cov txiaj ntsig kho kom zoo.

Kev phiv tshuaj

Cov tshuaj "Wazonit" ua rau lub txim tsis tsim nyog? Kev tshuaj xyuas tau qhia tias cov tshuaj no pab ua rau pom qhov tshwm sim ntawm ntau qhov kev mob tshwm sim los ntawm cov plab hnyuv sab hauv thiab cov kab ke. Xav txog cov feem ntau cov tam sim no.

kiv tob hau, mob taub hau, tsaus muag, mob ib ce, tsaug zog, mob caj dab, pw tsaug zog,
ua rau lub plawv dhia, lub plawv mob, lub plawv ntxhov, cuam tshuam rau cov ntshav siab,
poob teb ntawm lub zeem muag peripheral, tsis pom kev,
mob nyob rau hauv txoj cai hypochondrium, kev hloov pauv hauv lub siab, kev ua rau lub siab ntev ntawm cov kab mob ntawm lub qog thiab lub plab,
tsis qab los noj mov, xeev siab, qhov ncauj qhuav, cem quav, mob plab, ntuav, raws plab,
nce los ntshav, txhaws ntswg, los ntshav los ntawm cov pos hniav thiab cov kabmob hauv nruab nrog, qhov txo qis hauv cov ntsiab lus ntawm cov cellular hauv cov ntshav, ntshav tsis txaus,
tso dej tawm ntawm ib nrab ntawm lub cev, tsis yooj yim ntawm cov ntsia hlau phaj, o.

Peb tsis tuaj yeem hais tias cov tshuaj hauv cov lus nug feem ntau ua rau ua xua, tshwm sim hauv daim ntawv ntawm Quincke's edema, urticaria, khaus thiab tawv nqaij ua pob. Anaphylactic shock kuj tseem tuaj yeem tau.

Tshuaj ntau dhau

Puas yog overdose ntawm cov tshuaj "Vazonit" tau? Kev txheeb xyuas (cov qauv ntawm cov tshuaj ntawm no tau qhia hauv qab no) hais tias yog tias cov tshuaj noj tsis raug, cov tsos mob overdose tshwm sim sai heev. Tus neeg mob muaj qhov txo qis hauv cov ntshav siab, nrog rau xeev siab, palpitations, ua tsis taus pa, tsis muaj zog, zoo nkaus li tsis muaj cua, liab ntawm ib nrab ntawm lub cev thiab ua daus no. Muaj qee zaus, qhov xwm txheej no ua rau nws huam thiab tsis nco qab. Yog tias tus neeg mob tau mob txhab ua mob ntawm txoj hnyuv plab los sis ua kom plab hnyuv, ua kom los ntshav.

Yog tias muaj tshuaj ntau dhau nrog cov tshuaj hauv nqe lus nug, koj yuav tsum hu rau lub tsheb thauj neeg mob tam sim ntawd. Ua ntej tus kws kho mob tuaj txog, nws yog ib qho tsim nyog yaug lub plab, nrog rau haus dej haus kom tsawg.

Kev sib txuam

Cov tshuaj nyob rau hauv nqe lus nug cuam tshuam nrog ntau yam tshuaj. Hauv tshwj xeeb, nws txhim kho qhov kev ua ntawm cov tshuaj hauv qab no:

txwv kev tiv thaiv cov ntshav coagulability (i.e. kov tsis tau thiab ncaj qha anticoagulants),
txos cov ntshav siab
valproic acid (i.e., tshuaj anticonvulsant),
tshuaj tua kab mob koom ua ke pab pawg cephalosporins,
pob nyiaj rau kev kho mob ntshav qab zib.

Nws tseem yuav tsum tau sau tseg tias thaum noj nrog "Theophylline", kev haus ntau dhau ntawm tom kawg feem ntau tshwm sim.

Thaum siv ua ke nrog Cimetidine, qhov pheej hmoo ntawm kev noj tshuaj ntau tshaj ntawm Wasonite nce.

Cov ntaub ntawv tshwj xeeb

Cov neeg muaj lub raum khiav tsis zoo thaum noj Wazonite yuav tsum tau kev saib xyuas mob nkeeg xwm yeem.

Thaum mob hemorrhage hauv qhov muag ntawm lub qhov muag, kev kho mob yuav tsum nres tam sim.

Kev kho nrog tshuaj nyob rau hauv nqe lus nug yuav tsum tau ua nyob rau hauv kev tswj hwm ntawm cov ntshav siab tas li. Hauv cov neeg mob uas tsis khov thiab tsis muaj ntshav siab, kev noj tshuaj yuav tsum tau txo.

Hauv cov neeg muaj ntshav qab zib uas noj tshuaj hypoglycemic, noj Wasonit hauv koob tshuaj ntau tuaj yeem ua rau mob ntshav qab zib tsawg.

Nyob rau hauv cov ntaub ntawv ntawm kev siv tib lub sijhawm ntawm cov tshuaj no thiab cov tshuaj tiv thaiv tsis haum, nws yog ib qho tsim nyog los soj ntsuam tas li ntawm cov ntsuas ntawm cov ntshav coagulation.

Rau cov neeg mob uas nyuam qhuav raug phais, yuav tsum muaj ib txoj kev saib xyuas ntawm hematocrit thiab hemoglobin uas tsim nyog.

Hauv cov neeg laus, yuav tsum tau txhaj koob tshuaj.

Cov luam yeeb txo cov kev kho mob kom ntxim ntawm cov tshuaj muaj lus nug.

Lub sijhawm kho mob, haus cawv kom qaug zog.

Vim tias qhov tshwm sim ntawm kev tuaj yeem kiv taub hau, cov neeg mob tau hais qhia kom ceev faj thaum tsav tsheb.

Cov tshuaj zoo sib xws

Cov tshuaj noj yeeb tshuaj (analogues) yog cov tshuaj uas nyias muaj nyias pab, tab sis siv los kho ib yam mob. Cov lus sib piv ntawm cov tshuaj "Wazonit" yog "Xanthinol nicotinate, ntxiv rau" Thiocol "thiab" Kev ua kom tiav. Cov tshuaj no txhim kho cov kev mob hauv lub cev, suav nrog cov kabmob ntawm lub zeem muag thiab lub hlwb. Lawv kuj nce tus me nyuam thiab kev nqus.₂ hlwb hlwb thiab txo cov platelet aggregation.

Raws li rau kev txhais ntawm cov tshuaj hauv cov lus nug, lawv suav nrog Pentoxifylline, Flexital, Trental, Agapurin, Latren thiab lwm tus.

Cov tshuaj "Vazonit": tshuaj xyuas

Muaj ntau ntau ntawm kev txheeb xyuas txog cov tshuaj hauv cov lus nug. Feem ntau ntawm lawv muaj qhov zoo. Raws li cov neeg uas tau noj cov tshuaj no, Vazonit yog lub tswv yim zoo rau kev kho ntau yam kab mob cuam tshuam nrog kev ua rau lub zog tsis tuaj yeem. Tom qab noj cov tshuaj no, qhov mob ntawm cov neeg mob txhim kho qhov pom tseeb. Txawm li cas los xij, cov kws tshaj lij tau sib cav hais tias txhua yam vascular tuaj yeem kho nrog txoj kev nyuaj. Lawv yuav tsum muaj txoj kev kho nyob ntev ntev hauv kev saib xyuas tas li ntawm tus kws kho mob.

Qhov zoo ntawm cov tshuaj no suav nrog nws cov nqi tsawg. Cov neeg mob thov tias kev siv tshuaj zoo no tuaj yeem muas tau tsuas yog 250-350 rubles.

Tsis tas li, muaj qhov tsis zoo xyuas txog cov tshuaj nyob rau hauv nqe lus nug.Raws li txoj cai, lawv tau cuam tshuam nrog kev phiv uas tshwm sim thaum noj nws. Tsis tas li, yog tias cov tshuaj tsis raug noj raws cai, tus neeg mob yuav muaj cov tsos mob loj heev. Yog li, cov tshuaj "Vazonit" yuav tsum yog tsuas yog los ntawm cov kws kho mob paub dhau los, suav rau hauv tag nrho cov contraindications thiab kev ntsuas.