Dalacin (tsiav tshuaj): cov lus qhia rau kev siv

Cov tshuaj ntsiav 150 mg, 300 mg

Ib qho tshuaj ntsiav muaj:

cov tshuaj tshaj tawm yog Clindamycin hydrochloride 177.515 mg lossis 355.030 mg (sib npaug rau clindamycin 150 mg lossis 300 mg),

tus zam: magnesium stearate, pob kws nplej siab, talc, lactose monohydrate,

tshuaj ntsiav plooj muaj pes tsawg leeg: titanium dioxide (E 171), nkaws.

Cov khoom tawv opaque gelatin tsiav tshuaj nrog lub hau thiab lub cev dawb, dub number case luam tawm hom "Pfizer" thiab cov code "Clin 150". Tus txheem ntawm cov tsiav tshuaj yog hmoov dawb (rau qhov ntau npaum li 150 mg).

Cov khoom tawv opaque gelatin tsiav tshuaj nrog lub hau thiab lub cev dawb, dub number case luam tawm hom "Pfizer" thiab cov code "Clin 300". Tus txheem ntawm cov tsiav tshuaj yog hmoov dawb (rau qhov ntau npaum li 300 mg).

Cov chaw muag tshuaj

Tom qab kev tswj hwm ntawm qhov ncauj, clindamycin tau nrawm thiab yuav luag nqus (90% ntawm cov koob tshuaj).

Kev noj zaub mov zoo ib txhij tsis cuam tshuam rau kev txiav txim siab ntawm cov tshuaj hauv ntshav ntshav.

Ntshav Siab Ntau

Hauv cov neeg laus noj qab haus huv, cov ntshav plasma ntau ntau yog li 2-3 mg / L thiab raug soj ntsuam ib teev tom qab kev tswj hwm ntawm 150 mg ntawm clindamycin hydrochloride lossis 4-5 mg / L tom qab kev tswj hwm ntawm 300 mg. Tom qab ntawd, cov ntshav plasma concentration dauv qeeb qis, seem saum toj 1 mg / L rau ntau tshaj 6 teev.
Plasma concentration nce linearly nyob rau hauv qhov nce nyob rau hauv lub koob noj.
Ntshav siab yuav tau tshaj tawm me ntsis hauv cov neeg mob ntshav qab zib dua li cov neeg mob noj qab nyob zoo.
Qhov nruab nrab roj ntsha ib nrab-lub neej ntawm clindamycin los ntawm cov ntshav dej yog 2.5 teev.

Ntshav Protein losis tswvyim dabtsi

Kev khi rau cov ntshav plasma protein yog li ntawm 80 txog 94%.

Kev ncig hauv cov ntaub so ntswg thiab dej ntawm lub cev

Clindamycin yog dav faib nyob rau hauv cov kua dej ntau dhau ntawm cov kua dej ntxiv thiab tso ntshav thiab hauv cov ntaub so ntswg. Diffusion rau hauv cerebrospinal kua yog tsawg tsawg.

Clindamycin yog tshuaj tiv thaiv hauv lub siab.

Kwv yees li 10% ntawm cov tshuaj nyob rau hauv daim ntawv nquag yog tawm hauv cov zis thiab 3.6% yog tawm hauv cov quav. Cov seem yog tawm los uas tsis ua haujlwm ntawm metabolites.

Ntshav clindamycin ntau tsis hloov vim yog los ntawm hemodialysis lossis peritoneal lim ntshav.

Cov cwj pwm hauv qab no tsis pub muaj kev txwv qis tshaj plaws (MIC) raug siv los cais qhov sib txawv ntawm cov tshuaj muaj sia, cov kab mob muaj feem cuam tshuam tsawg, thiab cov kab mob muaj feem cuam tshuam tsawg los ntawm cov kab mob tiv taus:

S ≤ 2 mg / L thiab R> 2 mg / L.

Qhov ntau ntawm cov kis tau kuj yuav txawv rau qee hom nyob ntawm thaj av ntawm thaj chaw thiab dhau sijhawm, thiab nws yog qhov tsim nyog kom muaj cov ntaub ntawv ntawm thaj av ntawm cov xwm txheej ntawm kev nthuav dav ntawm qhov tsis kam, tshwj xeeb hauv kev kho mob ntawm kev sib kis mob hnyav. Cov ntaub ntawv no tsuas yog kwv yees lub tswv yim ntawm qhov muaj feem ua rau muaj kev phom sij rau cov tshuaj tua kab mob no.

Gram-zoo cocci, suav nrog:

- Streptococci uas tsis yog ib qho ntawm cov pab pawg

Gram-negative bacilli, suav nrog:

- Clostridium (tshwj tsis yog perfringens thiab difficile)

- Enterococci (tshwj tsis yog Enterococcus faecium)

Gram-negative aerobic cov kab mob

- Tsis-fermenting gram-tsis zoo bacilli

- (Acinetobacter, Pseudomonas, thiab lwm yam)

Clindamycin ua qauv qhia hauv vitro thiab hauv vivo kev ua haujlwm tawm tsam Toxoplasma gondii.

* Feem ntau ntawm cov kabmob methicillin tiv thaiv yog kwv yees li 30 mus rau 50% rau txhua tus staphylococci thiab raug soj ntsuam feem ntau hauv tsev kho mob.

Kev ntsuas rau siv

Clindamycin yog npaj rau kev kho mob ntawm kev kis mob hnyav los ntawm cov kab mob ua tau zoo:

- mob ntawm pob ntseg, qhov ntswg thiab caj pas,

- Tom qab mob plab zom mov,

Muaj kev zam tau yog kev kis mob rau cov pob txha caj qaum, txawm tias nws yog ua los ntawm cov kab mob nyoos me, vim tias Dalacin® tsis txawv txav mus rau cov kua dej cerebrospinal hauv cov tshuaj kho tau tus nqi.

Kev tiv thaiv kev kis tus mob endocarditis hauv kev kho mob sab nrauv thiab kev kho mob ntawm lub ntsws ua pa loj hauv cov neeg mob uas muaj kev fab tshuaj rau beta-lactams.

Cov lus pom zoo ntawm cov lus qhia ntawm kev ua haujlwm rau kev siv tshuaj tua kab mob kom zoo yuav tsum raug txiav txim siab.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj yog siv sab hauv, txhawm rau kom tsis txhob khaus ntawm txoj hlab pas, lub tsiav tshuaj yuav tsum tau muab ntxuav nrog ib khob dej (250 ml).

Kev noj tshuaj ib txwm ib hnub yog 600-1800 mg / hnub, muab faib ua 2, 3 lossis 4 koob tshuaj sib npaug. Qhov siab tshuaj ntau tshaj txhua hnub yog 2400 mg.

Kev saib xyuas cov menyuam yaus

Tsuas tshuaj ntawm 8-25 mg / kg ib hnub twg, muab faib ua 3 lossis 4 koob tshuaj sib npaug.

Siv rau cov menyuam yaus yog qhov qhia tau yog tias lawv tuaj yeem nqos tag nrho cov tshuaj ntsiav.

Cov neeg laus cov neeg mob

Pharmacokinetic cov kev tshawb fawb tom qab qhov ncauj los yog kev tswj hwm ntawm clindamycin tsis qhia txog qhov sib txawv tseem ceeb ntawm cov neeg mob hluas thiab cov neeg laus uas lub siab ua haujlwm thiab lub cev tsis zoo (coj mus rau lub hnub nyoog) lub raum ua haujlwm. Hauv qhov no, kev hloov kho koob tshuaj rau cov neeg mob laus uas lub siab ua haujlwm thiab li qub (noj rau hauv lub hnub nyoog ua haujlwm) lub raum tsis ua haujlwm.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Hauv cov neeg mob uas lub raum tsis txaus, yuav tsum tau txhaj tshuaj los ntawm clindamycin tsis yog yuav tsum tau ua.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Hauv cov neeg mob uas muaj daim siab tsis txaus, tshuaj kho tus mob clindamycin tsis tas yuav ua haujlwm.

Koob tshuaj rau cov kev qhia tshwj xeeb

Kev Kho Mob rau Beta Hemolytic Streptococcus Infections

Cov koob tshuaj xav kom haum rau cov koob tshuaj saum toj no rau cov neeg laus thiab menyuam yaus Txoj kev kho yuav tsum txuas txuas ntxiv tsawg kawg 10 hnub.

Kev kho mob ntawm tus mob streptococcal tonsillitis lossis pharyngitis

Qhov koob tshuaj pom zoo yog 300 mg ob zaug ib hnub rau 10 hnub.

Kev kho tus neeg mob rau cov mob ua mob rau ntawm lub plab (pelvic plab hnyuv siab raum)

Cov kev kho mob yuav tsum tau pib nrog kev daws teeb meem nrog Dalacin C Phosphate (ntawm koob tshuaj 900 mg txhua 8 teev nyob rau hauv kev sib xyaw nrog cov tshuaj tua kab mob nrog qhov ntsuas qhov tsim nyog ntawm kev txiav txim siab tiv thaiv gram-negative aerobic microorganisms, piv txwv li, nrog gentamicin ntawm koob tshuaj 2.0 mg / kg, tom qab ntawd koob tshuaj 1.5 mg / kg txhua 8 teev hauv cov neeg mob uas lub raum tsis ua haujlwm). Kev tswj hwm cov tshuaj tiv thaiv yuav tsum txuas ntxiv tsawg kawg 4 hnub thiab tsawg kawg 48 teev tom qab tus neeg mob tus mob zoo dua.

Tom qab ntawd, koj yuav tsum tau noj cov tshuaj Dalacin® ntxiv ntawm qhov ncauj ntawm 450-600 mg txhua 6 teev txhua hnub mus txog thaum ua tiav cov chav kho mob nrog tag nrho lub sijhawm ntawm 10-14 hnub.

Pob txha thiab mob sib kis

Qhov koob tshuaj pom zoo yog 7.5 mg / kg txhua 6 teev.

Kev tiv thaiv ntawm endocarditis nyob rau hauv cov neeg mob uas penicillin rhiab heev

Hauv cov neeg mob cov neeg laus, cov koob tshuaj pom zoo yog 600 mg 1 teev ua ntej kev ua tiav; cov menyuam yaus: 20 mg / kg 1 teev ua ntej txheej txheem.

Cov Yuav Tsum Muaj

- Kev tsis haum xeeb rau cov tshuaj muaj txiaj ntsig clindamycin, lincomycin lossis rau ib yam ntawm cov tsis suav nrog

- cov menyuam yaus hnub nyoog qis dua 6 xyoo

- thawj zaum thib plaub ntawm cev xeeb tub thiab lactation

- cov kab mob tsis muaj mob txaus lactase, cov kab mob muaj keeb fructose tsis txaus, qabzib / galactose malabsorption syndrome

Cov tshuaj sib cuam tshuam

Vitamin K Antagonists

Txhim kho cov tshuaj vitamin K cuam tshuam thiab / lossis los ntshav, ntau dua kev saib xyuas kev noj qab haus huv hauv ntiaj teb (INR). Yog tias tsim nyog, koob tshuaj tiv thaiv kab mob K kho mob K raug kho thaum kho cov tshuaj clindamycin thiab tom qab tshem tawm.

Txhais tau tias siv tshuaj pleev rau hauv cov kab mob ntawm txoj hnyuv, antacids thiab adsorbents

Txhais tau tias siv tshuaj pleev rau hauv cov kab mob ntawm txoj hnyuv, ua kom hluav ncaig thiab tshuaj tua kab mob (aluminium, calcium thiab magnesium ntsev) los ntawm lawv tus kheej thiab ua ke nrog alginates txo kev nqus ntawm qee lwm yam tshuaj uas sib luag hauv txoj hnyuv huam. Ntawm cov tshuaj uas muaj qhov txo qis hauv kev nqus hauv plab yog acetylsalicylic acid, H2-blockers thiab lansoprazole, bisphosphonates, cation kev hloov pauv, tshuaj tua kab mob ntawm qee chav kawm (fluoroquinolones, tetracyclines thiab lincosamides) thiab qee cov tshuaj tiv thaiv kab mob, kev kho mob digitalis, glucocorticoids cov thyroid hormones, phenothiazine antipsychotics, sulpiride, qee qhov beta-blockers, penicillamine, ions (hlau, phosphorus, fluorine), chloroquine, ulipristal thiab fexofenadine.

Raws li kev ceev faj, cov tshuaj no yuav tsum tau siv rau hauv tshuaj pleev hauv cov kab mob ntawm lub plab zom mov los yog antacids nrog lub sijhawm sib xyaw nrog kev noj lwm yam tshuaj (yog tias ua tau, ntau dua ob teev).

Kev txo qis ntshav cov tshuaj ntawm cov tshuaj tiv thaiv kab mob ua rau cuam tshuam nrog kev pheej hmoo ntawm ploj ntawm cov tshuaj tiv thaiv immunosuppressive. Kev soj ntsuam ntau zaus ntawm cyclosporine ntau nyob rau hauv cov ntshav thiab, yog tias tsim nyog, nce ntxiv hauv nws cov koob tshuaj.

Kev txo qis ntshav cov tshuaj ntawm cov tshuaj tiv thaiv kab mob ua rau cuam tshuam nrog kev pheej hmoo ntawm ploj ntawm cov tshuaj tiv thaiv immunosuppressive. Nquag tshuaj xyuas tacrolimus ntau nyob rau hauv cov ntshav thiab, yog tias tsim nyog, nce ntxiv hauv nws cov koob tshuaj.

Cov teeb meem tshwj xeeb muaj feem nrog INR hloov pauv

Ntau qhov xwm txheej ntawm cov neeg ua si antivitamin K tau nce siab pom nyob hauv cov neeg mob tau txais tshuaj tua kab mob. Cov yam muaj feem yuav suav nrog qhov mob hnyav lossis mob o, nrog rau lub hnub nyoog thiab cov mob ntawm tus neeg mob. Hauv cov xwm txheej zoo li no, nws nyuaj rau txiav txim siab seb dab tsi ua rau muaj kev hloov pauv hauv INR - kis lossis kho. Txawm li cas los xij, qee cov chav kawm ntawm cov tshuaj tua kab mob hauv kev sib txuas nrog qhov tshwm sim no tau hais ntau dua li lwm tus, xws li fluoroquinolones, macrolides, cyclins, cotrimoxazole thiab qee cov cephalosporins.

Cov lus qhia tshwj xeeb

Pseudomembranous colitis thiab colitis cuam tshuam nrog kev siv tshuaj tua kab mob tau pom nrog yuav luag txhua tus kab mob antibacterial, suav nrog clindamycin, thiab lawv qhov mob hnyav tuaj yeem yog los ntawm mob sib khuav mus rau lub neej. Yog li, nws yog ib qho tseem ceeb uas yuav tsum xav txog qhov kev kuaj mob no yog tias mob raws plab pib lub sijhawm lossis tom qab siv cov tshuaj tiv thaiv kab mob. Yog tias tus kab mob tua kab mob ntsig txog tshuaj tua kab mob, clindamycin yuav tsum tau txiav tawm tam sim ntawd, tus kws kho mob yuav tsum tau sab laj thiab kev kho mob tsim nyog, suav nrog kev kho mob tshwj xeeb nrog Clostridium difficile. Hauv qhov xwm txheej no, kev siv cov tshuaj uas txwv plab hnyuv plab yog contraindicated.

Kev kub siab tsis haum thiab ua xua tuaj yeem tshwm sim, suav nrog kev siv tshuaj anaphylactic uas tuaj yeem tsim kev phom sij tau rau lub neej. Hauv cov xwm txheej zoo li no, clindamycin yuav tsum tau tsum tsis ua ntxiv thiab tsim kev kho kom tsim nyog.

Clindamycin yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj keeb kwm muaj mob hawb pob thiab mob ua xua.

Cov tsos mob nyob rau theem pib ntawm kev kho mob dav dav erythema nrog kev kub taub hau thiab pustules tej zaum yuav yog tus tsos mob ntawm kev kho kom zoo pantulosis, kev kho yuav tsum tau txiav, kev siv txuas ntxiv ntawm clindamycin yog contraindicated.

Lub siab ua haujlwm tsis zoo

Yog tias ua rau lub siab ua haujlwm tsis zoo, ua kom lub siab cov ntshav clindamycin ntau zuj zus thiab qhov nce siab hauv nws lub neej ib nrab tau pom.

Xws li kev kho mob ntev, nws yog ib qho tsim nyog yuav tau ua tib zoo saib xyuas qhov muaj pes tsawg leeg ntawm cov ntshav, nplooj siab thiab lub raum ua haujlwm.

Kev siv cov tshuaj tua kab mob, tshwj xeeb tshaj yog siv sijhawm ntev, tuaj yeem ua rau pom thiab xaiv cov kab mob uas tsis tshua muaj siab lossis kev ua kom muaj cov kab mob hu ua fungi. Thaum kis superinfection, nws yog ib qho tsim nyog yuav tsum pib kho kom tsim nyog.

Dalacin ® tsis tuaj yeem siv los kho tus mob meningitis, vim tias clindamycin tsis nkag mus rau hauv cov kua dej txha caj qaum.

Dalacin® muaj cov lactose. Nws siv yuav tsum raug zam nyob rau hauv cov neeg mob uas tsis haum lactose, lactase deficiency lossis glucose thiab galactose malabsorption syndrome (mob muaj kab mob tsis tshua muaj kab mob).

Hauv kev tshawb fawb embryonic ntawm kev txhim kho ntawm lub cev xeeb tub, tsis muaj kev cuam tshuam tsis zoo ntawm tus me nyuam hauv plab, tshwj qhov tshwj xeeb ntawm kev saib xyuas hauv kev txhaj tshuaj lom rau leej niam.

Clindamycin hla lub tsho me me.

Cov ntaub ntawv hais txog cov txiaj ntsig ntawm clindamycin thaum siv lub cev lossis hauv zej zog thaum thawj peb lub hlis cev xeeb tub tau txwv.

Hauv cov ntaub ntawv ntau muaj ntawm kev siv clindamycin thaum lub sijhawm thib ob thiab peb lub hlis ntawm cev xeeb tub, tsis muaj kev nce ntxiv ntawm qhov tshwm sim ntawm kev tsis ua haujlwm ntawm lub cev xeeb tub.

Yog li, muab cov ntaub ntawv muaj, nws tsis pom zoo kom siv clindamycin thaum thawj peb lub hlis cev xeeb tub.

Yog tias tsim nyog, uas tau tsim los ntawm tus kws kho mob koom nrog, clindamycin tuaj yeem siv lub sijhawm thib ob thiab thib peb lub cev xeeb tub.

Clindamycin nyob rau ntau qhov me me yog hauv cov kua mis. Muaj kev pheej hmoo ntawm kev mob plab hnyuv plab hauv cov menyuam mos. Yog li, raws li kev ceev faj, kev pub niam mis yuav tsum zam thaum lub sijhawm hloov tshuaj.

Kev tshawb nrhiav kab mob hauv cov nas uas kho nrog clindamycin tsis qhia txog cov nyhuv ntawm cov tshuaj ntawm fertility lossis mating muaj peev xwm.

Cov yam ntxwv ntawm cov nyhuv ntawm cov tshuaj ntawm lub peev xwm tsav tsheb thiab ua haujlwm nrog cov phom sij phom sij

Dalacin® tsis muaj kev cuam tshuam rau lub peev xwm tsav tsheb thiab ua haujlwm nrog cov txheej txheem lossis cuam tshuam rau nws me me.