Cov tshuaj insulin aspart ob-theem

Kev tsim cov tshuaj insulin, ib qho tshuaj ntawm tib neeg cov tshuaj insulin. Ib qho kev tshem tawm biphasic suav nrog kev sib xyaw ua ke ntawm insulin aspart (30%) thiab muaju ntawm insulin aspart tiv thaiv (70%). Insulin aspart tau los ntawm kev siv DNA thev naus laus zis siv kev siv tshuaj ntawm Saccharomyces cerevisiae, nyob rau hauv cov qauv molecular ntawm insulin, cov amino acid proline ntawm txoj haujlwm B28 yog hloov los ntawm aspartic acid.

Kws Tshuaj

Biphasic insulin aspart cuam tshuam nrog cov receptors ntawm cytoplasmic membrane ntawm cov hlwb thiab tsim cov txheej txheem insulin-receptor complex uas txhawb cov txheej txheem intracellular, suav nrog synthesis ntawm cov naj npawb ntawm cov enzymes tseem ceeb (hexokinase, pyruvate kinase, glycogen synthetase). Qhov kev poob qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav yog vim muaj qhov nce ntxiv hauv nws txoj kev thauj mus los, kev nce siab los ntawm cov leeg pob txha thiab cov nqaij mos adipose, thiab qhov txo qis hauv cov ntshav qabzib ntau hauv lub siab. Nws muaj tib yam haujlwm ntawm tib neeg cov insulin hauv cov hniav sib npaug. Kev hloov ntawm cov amino acid proline nyob hauv txoj hauj lwm B28 nrog aspartic acid txo cov leeg ntawm cov lwg me me los ua hexamers hauv cov kuab tshuaj lom, uas tau pom nyob hauv tib neeg lub cev cov tshuaj lom neeg. Hauv qhov no, insulin aspart yog nqus los ntawm subcutaneous rog sai dua li cov tshuaj insulin uas muaj nyob hauv tib neeg cov kua dej. Cov tshuaj insulin aspart protamin yog nqus tau ntev dua. Tom qab kev tswj hwm sc, cov txiaj ntsig tshwm sim tom qab 10-20 feeb, cov txiaj ntsig siab tshaj plaws tom qab 1 hours4 teev, lub sijhawm ua haujlwm tau ntev txog 24 teev (nyob ntawm qhov koob tshuaj, qhov chaw tswj hwm, ntshav txaus, lub cev kub thiab theem ntawm kev siv lub cev).

Thaum s / rau ib koob tshuaj 0.2 U / kg lub cev hnyav T_max - 60 feeb Kev khi rau cov ntshav muaj protein tsawg (0–9%). Cov tshuaj insulin concentration rov mus rau qhov qub tom qab 15-18 teev.

Cev xeeb tub thiab lactation

Siv thaum cev xeeb tub yog qhov ua tau yog tias qhov xav pom ntawm kev kho mob ntau dua qhov kev pheej hmoo rau tus me nyuam hauv plab (kev tshawb fawb txaus thiab nruj me ntsis tsis tau ua). Nws tsis paub meej tias insulin aspart biphasic tuaj yeem muaj cov nyhuv embryotoxic thaum siv thaum cev xeeb tub thiab seb nws puas cuam tshuam cov kev muaj peev xwm ntawm kev muaj me nyuam.

Nyob rau lub sijhawm ua rau muaj kev pib cev xeeb tub thiab nyob rau tag nrho nws lub sijhawm, nws yuav tsum tau ua tib zoo saib xyuas cov neeg mob ntshav qab zib mellitus thiab saib xyuas cov ntshav qabzib hauv cov ntshav. Qhov xav tau rau insulin, raws li txoj cai, txo qis hauv thawj peb hlis thiab maj mam nce ntxiv hauv qib thib ob thiab thib peb ntawm cev xeeb tub.

Thaum yug menyuam thiab sai li sai tau tom qab lawv, qhov xav tau rau cov tshuaj insulin tuaj yeem txo qis, tab sis ceev ceev rov qab mus rau theem uas tau muaj ua ntej cev xeeb tub.

Tsis paub meej tias cov tshuaj puas kis mus rau niam mis. Thaum lub sijhawm lactation, tej zaum yuav xav tau kev hloov kho koob tshuaj.

Tshuaj insulin aspart biphasic: Sab sij huam

Edema thiab lub zog ua kom tsis zoo (thaum pib kho), ua xua hauv zos (hyperemia, o, khaus ntawm daim tawv nqaij ntawm qhov chaw txhaj tshuaj), kev tawm tsam dav dav (tawv nqaij ua pob khaus, khaus, nce tawm hws, ua tsis taus pa ua haujlwm, ua pa nyuaj, tachycardia, txo ntshav siab, mob taub hau) edema), lipodystrophy ntawm thaj chaw txhaj tshuaj.

Kev sib txuam

Ob-theem insulin aspart yog pharmaceutically incompatible nrog kev daws teeb meem ntawm lwm yam tshuaj. Cov nyhuv hypoglycemic yog txhim kho los ntawm qhov ncauj hypoglycemic, sulfanilamides, MAO inhibitors (suav nrog furazolidone, procarbazine, selegiline), carbonic anhydrase inhibitors, ACE inhibitors, anabolic steroids (suav nrog stanozolol, oxandrolone, metroprotinol thiab tetroprotinol) , disopyramide, fibrates, fluoxetine, ketoconazole, mebendazole, theophylline, cyclophosphamide, fenfluramine, pyridoxine, quinidine, quinine, chloroquine, ethanol thiab ethanol uas muaj cov tshuaj. Hypoglycemic los ntawm lus glucocorticoids, glucagon, kev loj hlob lawm, thyroid hormones, estrogens, progestogens (piv txwv li qhov ncauj contraceptives), thiazide diuretics, CCB, heparin, sulfinpyrazone, sympathomimetics (xws li epinephrine, salbutamol, terbutaline), Isoniazid, phenothiazine derivatives, danazol, tricyclics, diazoxide, morphine, nicotine, phenytoin.

Beta-blockers, clonidine, lithium ntsev, reserpine, salicylates, pentamidine - tuaj yeem ob leeg txhim kho thiab ua kom cov nyhuv tsis muaj zog hypoglycemic ntawm insulin.

Biphasic insulin aspart: Kev noj tshuaj thiab kev tswj hwm

P / c, tam sim ua ntej noj mov, yog tias tsim nyog - sai sai tom qab noj mov. Qhov kev txhaj tshuaj yog nqa tawm hauv tus ncej lossis sab xub ntiag phab ntsa, lossis hauv xub pwg lossis pob tw. Nws yog ib qho tsim nyog yuav tau hloov chaw txhaj tshuaj nyob rau thaj tsam anatomical (tiv thaiv kev txhim kho ntawm lipodystrophy). Qhov kub ntawm cov tshuaj insulin yuav tsum nyob ntawm chav sov.

Cov koob tshuaj ntawm cov tshuaj insulin aspart biphasic yog txiav txim los ntawm tus kws kho mob ntawm tus kheej hauv txhua kis, raws li cov concentration ntawm cov piam thaj hauv cov ntshav. Qhov nruab nrab, qhov tshuaj txhua hnub yog 0.5-1 units / kg lub cev hnyav. Nrog cov tshuaj insulin tsis kam (piv txwv, hauv kev rog), kev xav tau cov tshuaj insulin txhua hnub yuav raug nce, thiab nyob rau hauv cov neeg mob uas muaj qhov endogenous insulin zais cia.

Kev tiv thaiv kev nyab xeeb

Ob-theem tshuaj insulin aspart yuav tsum tsis txhob siv iv. Kev noj tshuaj tsis txaus los sis txiav tawm kev kho mob (tshwj xeeb nrog hom 1 mob ntshav qab zib mellitus) tuaj yeem ua rau kev loj hlob ntawm hyperglycemia lossis ntshav qab zib ketoacidosis. Raws li txoj cai, hyperglycemia manifests nws tus kheej maj mam dhau ob peb teev lossis hnub (cov tsos mob ntawm hyperglycemia: xeev siab, ntuav, qaug zog, liab thiab daj ntawm daim tawv nqaij, qhov ncauj qhuav, nce zis, nqhis dej thiab tsis qab los noj mov, qhov tsos ntawm tus ntxhiab ntawm acetone hauv kev ua pa tawm) thiab yog tias tsis muaj kev kho kom zoo yuav ua rau tuag taus.

Tom qab them nyiaj rau cov pluas noj carbohydrate, piv txwv li, thaum lub sij hawm kho insulin ntau dua, cov neeg mob yuav muaj cov tsos mob tshwm sim ua ntej ntawm hypoglycemia, uas cov neeg mob yuav tsum tau qhia txog. Hauv cov neeg mob ntshav qab zib uas muaj cov khoom siv tswj lub cev kom zoo rau lub cev, cov mob ntshav qab zib lig dhau los tom qab thiab nce qeeb dua. Hauv qhov no, nws raug nquahu kom ua haujlwm los tswj kev ua kom lub cev zom zaub mov zoo, nrog rau saib xyuas qib ntawm cov piam thaj hauv cov ntshav.

Ob-theem insulin aspart yuav tsum tau siv nyob rau hauv kev sib txuas ncaj qha nrog kev noj zaub mov. Nws yog ib qho tsim nyog yuav tsum coj mus rau hauv tus nqi siab ntawm qhov pib ntawm cov nyhuv hauv kev kho mob ntawm cov neeg mob uas muaj kab mob concomitant lossis noj tshuaj uas ua rau qeeb qis dua qhov nqus ntawm cov khoom noj. Nyob rau hauv muaj cov kab mob concomitant, tshwj xeeb ntawm kev kis tus kab mob, xav tau cov tshuaj insulin nce ntxiv. Lub raum tsis zoo thiab / lossis lub siab ua haujlwm tuaj yeem ua rau txo qis hauv insulin. Tsis noj zaub mov ua si los yog kev tawm dag zog tsis npaj yuav tuaj yeem coj mus rau hauv hypoglycemia.

Nrog rau kev txhim kho hypoglycemia lossis hyperglycemia, qhov kev txo qis ntawm kev saib xyuas thiab qhov cuam tshuam ceev yog qhov ua tau, uas tuaj yeem muaj kev phom sij thaum tsav tsheb lossis ua haujlwm nrog cov tshuab thiab tshuab. Cov neeg mob yuav tsum qhia rau kev ntsuas kom tiv thaiv kev txhim kho hypoglycemia thiab hyperglycemia. Qhov no tseem ceeb tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj los yog tsawg dua cov tsos mob ntawm kev tsim kho tus mob hypoglycemia lossis raug mob los ntawm kev pheej muaj ntshav ntau ntawm cov ntshav siab.

Cov Npe Lag Luam

NovoMix 30 Penfill: raug tshem tawm rau kev coj ua subcutaneous ntawm 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 30 FlexPen: raug tshem tawm rau kev coj ua subcutaneous ntawm 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 50 FlexPen: raug tshem tawm rau kev coj ua subcutaneous ntawm 100 PIECES / ml, Novo Nordisk (Denmark)

NovoMix 70 FlexPen: raug tshem tawm rau kev coj ua subcutaneous ntawm 100 PIECES / ml, Novo Nordisk (Denmark)

Pharmacological kev txiav txim

Nws cuam tshuam nrog cov receptors ntawm cytoplasmic membrane ntawm cov hlwb thiab ua ib qho insulin-receptor complex uas txhawb cov txheej txheem intracellular, suav nrog synthesis ntawm cov naj npawb ntawm cov enzymes tseem ceeb (hexokinase, pyruvate kinase, glycogen synthetase). Qhov kev poob qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav yog vim muaj qhov nce ntxiv hauv nws txoj kev thauj mus los, kev nce siab los ntawm cov leeg pob txha thiab cov nqaij mos adipose, thiab qhov txo qis hauv cov ntshav qabzib ntau hauv lub siab. Nws muaj tib yam haujlwm ntawm tib neeg cov insulin hauv cov hniav sib npaug. Kev hloov ntawm cov amino acid proline nyob hauv txoj hauj lwm B28 nrog aspartic acid txo cov leeg ntawm cov lwg me me los ua hexamers hauv cov kuab tshuaj lom, uas tau pom nyob hauv tib neeg lub cev cov tshuaj lom neeg. Hauv qhov no, insulin aspart yog nqus los ntawm subcutaneous rog sai dua li cov tshuaj insulin uas muaj nyob hauv tib neeg cov kua dej. Cov tshuaj insulin aspart protamin yog nqus tau ntev dua. Tom qab kev tswj hwm sc, cov txiaj ntsig tshwm sim tom qab 10-20 feeb, cov txiaj ntsig siab tshaj plaws tom qab 1 hours4 teev, lub sijhawm ua haujlwm tau ntev txog 24 teev (nyob ntawm qhov koob tshuaj, qhov chaw tswj hwm, ntshav txaus, lub cev kub thiab theem ntawm kev siv lub cev). Thaum s / rau ib koob tshuaj 0.2 U / kg lub cev hnyav Tmax - 60 feeb Kev khi rau cov ntshav muaj protein tsawg (0–9%). Cov tshuaj insulin concentration rov mus rau qhov qub tom qab 15-18 teev.

Cov yam ntxwv ntawm cov tshuaj Insulin aspart biphasic

Kev tsim cov tshuaj insulin, ib qho tshuaj ntawm tib neeg cov tshuaj insulin. Ib qho kev tshem tawm biphasic suav nrog kev sib xyaw ua ke ntawm insulin aspart (30%) thiab muaju ntawm insulin aspart tiv thaiv (70%). Cov tshuaj insulin aspart tau los ntawm cov cuab yeej siv DNA thev naus laus zis siv kev lim Saccharomyces cerevisiae, hauv cov qauv molecular ntawm cov kua dej, cov amino acid proline ntawm txoj haujlwm B28 yog hloov los ntawm aspartic acid.

Kev phiv los ntawm cov tshuaj Insulin aspart biphasic

Edema thiab ua kom rov zoo siab yuam kev (thaum pib kho), kev tsis haum tshuaj hauv zos (hyperemia, o, khaus ntawm daim tawv nqaij ntawm qhov chaw txhaj tshuaj), kev tsis haum tshuaj (ua pob khaus, khaus, nce tawm hws, ua tsis taus pa muaj nuj nqi, ua pa nyuaj, tachycardia, txo ntshav siab, mob taub hau) edema), lipodystrophy ntawm thaj chaw txhaj tshuaj.

Noj ntau dhau

Cov tsos mob hypoglycemia - "txias" tawm hws, pallor ntawm daim tawv nqaij, poob siab, tshee, ntxhov siab, txawv txawv, qaug zog, tsis meej pem, tsis hnov qab, kiv taub hau, tshaib plab heev, tsis pom kev ib ntus, mob taub hau, xeev siab, tachycardia, cramps, lub paj hlwb tsis zoo coma.

Kev Kho Mob: tus neeg mob tuaj yeem nres ntshav qab zib kom tsawg los ntawm kev noj ntshav qabzib, qab zib lossis carbohydrate cov zaub mov sab hauv. Hauv qhov xwm txheej loj - hauv / hauv 40% kev daws teeb meem dextrose, hauv / m, s / c - glucagon. Tom qab nws rov qab nco qab, tus neeg mob tau pom zoo kom noj cov khoom noj uas muaj cov khoom noj carbohydrate kom tiv thaiv kev rov qab txhim kho hypoglycemia.

Ceev faj tshuaj insulin aspart biphasic

Koj tsis tuaj yeem nkag mus hauv iv. Kev noj tshuaj tsis txaus los sis txiav tawm kev kho mob (tshwj xeeb nrog hom 1 mob ntshav qab zib mellitus) tuaj yeem ua rau kev loj hlob ntawm hyperglycemia lossis ntshav qab zib ketoacidosis. Raws li txoj cai, hyperglycemia manifests nws tus kheej maj mam dhau ob peb teev lossis hnub (cov tsos mob ntawm hyperglycemia: xeev siab, ntuav, qaug zog, liab thiab daj ntawm daim tawv nqaij, qhov ncauj qhuav, nce zis, nqhis dej thiab tsis qab los noj mov, qhov tsos ntawm tus ntxhiab ntawm acetone hauv kev ua pa tawm) thiab yog tias tsis muaj kev kho kom zoo yuav ua rau tuag taus.

Cov tshuaj yuav tsum tau siv nyob rau hauv kev sib txuas ncaj qha nrog kev ua zaub mov noj. Nws yog ib qho tsim nyog yuav tsum coj mus rau hauv tus nqi siab ntawm qhov pib ntawm cov nyhuv hauv kev kho mob ntawm cov neeg mob uas muaj kab mob concomitant lossis noj tshuaj uas ua rau qeeb qis dua qhov nqus ntawm cov khoom noj. Nyob rau hauv muaj cov kab mob concomitant, tshwj xeeb ntawm kev kis tus kab mob, xav tau cov tshuaj insulin nce ntxiv. Lub raum tsis zoo thiab / lossis lub siab ua haujlwm tuaj yeem ua rau txo qis hauv insulin. Tsis noj zaub mov ua si los yog kev tawm dag zog tsis npaj yuav tuaj yeem coj mus rau hauv hypoglycemia.

Hloov chaw ntawm tus neeg mob mus rau ib hom tshiab ntawm insulin lossis kev tsim tshuaj insulin ntawm lwm qhov chaw tsim khoom yuav tsum tau ua nyob rau hauv kev saib xyuas mob nruj, kev hloov kho koob tshuaj kuj yuav tsum tau ua. Yog tias tsim nyog, kev hloov kho tshuaj tuaj yeem twb ua tiav thaum thawj zaug txhaj tshuaj lossis thaum thawj lub asthiv lossis hli kho. Ib qho kev hloov pauv ntawm lub koob tshuaj kuj yuav tsum tau muaj kev hloov pauv ntawm kev noj zaub mov thiab nrog kev tawm dag zog lub cev. Kev tawm dag zog tam sim ntawd tom qab noj mov tuaj yeem nce koj qhov kev pheej hmoo ntawm lub qog ntshav qab zib.

Lub hauv paus ntsiab lus ntawm kev khiav haujlwm

Cov tshuaj no khi rau cov tshuaj insulin hauv daim ntaub adipose thiab cov leeg nqaij. Cov theem ntawm cov piam thaj hauv cov ntshav yog txo vim qhov tseeb hais tias cov ntaub so ntswg tuaj yeem cuam tshuam ntau dua cov piam thaj, ntxiv mus, nws zoo nkag mus rau hauv lub hlwb, thaum tus nqi ntawm nws tsim nyob rau hauv lub siab, ntawm qhov tsis sib xws, ua rau qis qis. Cov txheej txheem ntawm kev cais cov rog hauv lub cev sib zog ua kom zoo thiab ua kom ceev dua cov khoom sib xyaw ntawm cov protein.

Qhov kev txiav txim ntawm cov tshuaj pib hauv 10-20 feeb, thiab nws qhov siab tshaj plaws nyob rau hauv cov ntshav tau sau tseg tom qab 1-3 teev (qhov no yog 2 zaug nrawm dua li piv rau tib neeg cov tshuaj hormones ib txwm). Xws li cov tshuaj tua kab mob monocomponent insulin yog muag nyob hauv kev lag luam npe NovoRapid (dua li nws, kuj tseem muaj ob-theem insulin aspart, uas sib txawv hauv nws muaj pes tsawg leeg).

Cov tshuaj insipipide

Biphasic insulin aspart muaj tib lub ntsiab cai ntawm kev cuam tshuam pharmacological ntawm lub cev. Qhov txawv yog tias nws muaj cov tshuaj insulin luv luv (ua tau aspart) thiab nruab nrab-qog hormone (protamine-insulin aspart). Qhov piv ntawm cov insulins hauv kev noj tshuaj muaj raws li nram no: 30% yog yam tshuaj tiv thaiv sai thiab 70% yog lub caij nyoog ntev.

Qhov tseem ceeb ntawm cov tshuaj pib cia tam sim tom qab kev tswj hwm (hauv 10 feeb), thiab 70% ntawm tas cov tshuaj tsim cov tshuaj insulin nyob rau hauv daim tawv nqaij. Nws raug tso tawm qeeb dua thiab ua rau thaj tsam li 24 teev.

Kuj tseem muaj txoj hauv kev kho qhov uas kev siv tshuaj insulin luv luv (aspart) thiab ultra-long-acting hormone (degludec) ua ke. Nws lub npe lag luam yog Ryzodeg. Txhawm rau nkag mus rau cov cuab yeej no, xws li cov tshuaj zoo sib xyaw ua ke, koj tuaj yeem tsuas subcutaneously, qee zaus hloov thaj chaw rau kev txhaj tshuaj (kom tsis txhob muaj kev txhim kho lipodystrophy). Lub sijhawm ntawm cov tshuaj nyob rau theem ob yog txog li 2 txog 3 hnub.

Yog hais tias tus neeg mob feem ntau yuav tsum tau txhaj ntau hom tshuaj hormones, ces tej zaum nws yog qhov zoo dua rau nws siv ob-theem insulin aspart. Qhov no txo qis ntawm ntau cov kev txhaj tshuaj thiab pab tswj tau glycemia zoo. Tab sis tsuas yog cov kws endocrinologist tuaj yeem xaiv cov kev kho mob zoo tshaj plaws raws li cov txiaj ntsig ntawm kev tshuaj ntsuam thiab cov ntaub ntawv tshuaj xyuas lub hom phiaj.

Qhov zoo thiab qhov tsis zoo

Cov tshuaj insulin aspart (biphasic thiab ib-theem) yog qhov txawv me ntsis ntawm tib neeg cov insulin. Hauv qee txoj haujlwm, cov amino acid proline yog hloov los ntawm aspartic acid (tseem hu ua aspartate). Qhov no tsuas yog txhim kho cov yam ntxwv ntawm lub cev thiab tsis nyob rau hauv txhua txoj kev cuam tshuam nws zoo zam, ua si thiab tsis tshua muaj allergenicity. Ua tsaug rau qhov hloov kho no, cov tshuaj no pib ua sai dua li nws ntxiv.

Ntawm qhov tsis zoo ntawm cov tshuaj nrog hom insulin no, nws muaj peev xwm sau cia, txawm hais tias tsis tshua muaj tshwm sim, tab sis tseem muaj kev phiv.

Lawv tuaj yeem pom lawv tus kheej hauv daim ntawv ntawm:

o thiab mob ntawm qhov chaw txhaj tshuaj,
ua yeeb yaj kiab
daim tawv nqaij ua pob
daim tawv nqaij qhuav,
kev fab tshuaj tiv thaiv.

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv kom tsis txhob siv tshuaj yog qee tus tsis tuaj yeem, ua xua thiab cov ntshav qab zib qis (hypoglycemia). Kuj tseem tsis tau muaj kev tshawb fawb tswj txog kev siv cov tshuaj insulin no thaum cev xeeb tub thiab lactation. Cov kev sim ua ntej tsiaj txhu tau pom tias hauv cov koob tshuaj uas tsis dhau qhov kev pom zoo, cov tshuaj cuam tshuam rau lub cev hauv tib txoj kev ib yam nkaus li tib neeg cov insulin.

Nyob rau tib lub sijhawm, thaum txoj kev muab tshuaj tau ntau dua 4-8 zaug hauv cov tsiaj, kev yug me nyuam tau pom nyob rau thaum ntxov, kev txhim kho kev tsis ua haujlwm ntawm kev yug me nyuam hauv cov menyuam thiab muaj teeb meem nrog kev coj tus kheej hauv theem tom qab ntawm cev xeeb tub.

Nws tsis paub meej tias cov tshuaj no puas tau mus rau hauv niam cov mis, yog li ntawd nws tsis pom zoo rau cov poj niam kom pub niam mis thaum kho. Yog tias tus neeg mob xav tau cov tshuaj insulin thaum cev xeeb tub, cov tshuaj yeej ib txwm xaiv los ntawm kev sib piv ntawm cov txiaj ntsig rau leej niam thiab kev pheej hmoo rau tus me nyuam hauv plab.

Raws li txoj cai, thaum pib cev xeeb tub, qhov xav tau tshuaj insulin poob qis, thiab nyob rau lub sijhawm thib ob thiab thib peb lub sijhawm, yuav tsum tau noj tshuaj ntxiv. Nrog tus mob ntshav qab zib hauv nruab ce, qhov cuab yeej no tau siv tsis tau. Nyob rau hauv txhua rooj plaub, tsis tsuas yog tus kws kho mob endocrinologist, tab sis kuj yog ib tus kws kho mob kev paub txog tub rog-kuaj mob yuav tsum tau muab tshuaj kho zoo ib yam rau tus poj niam cev xeeb tub.

Hom tshuaj hormones no feem ntau tau pom zoo los ntawm cov neeg mob, thiab phiv los ntawm nws qhov kev siv tsis tshua muaj tshwm sim.

Cov tshuaj muaj ntau lub npe sib txawv raws li nws tso cai rau koj xaiv qhov zoo tshaj plaws ntawm kev txhaj tshuaj rau txhua tus neeg mob ib leeg zuj zus. Thaum kho nrog cov tshuaj no, nws yog ib qho tseem ceeb kom ua raws li kev coj noj coj ua pom zoo los ntawm tus kws kho mob thiab tsis txhob hnov qab txog kev noj haus, ua kom lub cev thiab muaj lub neej noj qab haus huv.

Daim ntawv tso tawm

Ncua Kev Kawm d / thiab 100 IU / ml 3 ml No. 5

Cov ntaub ntawv ntawm nplooj ntawv koj tab tom saib yog tsim rau cov ntaub ntawv lub hom phiaj nkaus xwb thiab tsis txhawb nqa nws tus kheej kev noj tshuaj hauv ib txoj kev twg. Cov peev txheej yog npaj los ua kom paub cov kws kho mob nrog cov lus qhia ntxiv txog qee yam tshuaj, yog li nce lawv qib kev tshaj lij. Kev siv yeeb tshuaj "Insulin aspart ob-theem" tsis muaj swb muab kev sab laj nrog tus kws tshaj lij, nrog rau nws cov lus pom zoo ntawm txoj kev siv thiab ntau npaum li cas ntawm koj cov tshuaj xaiv.

Insulin Aspart ob-theem

Qhov kev npaj tau los ntawm tshwj xeeb DNA thev naus laus zis siv kev ua ntawm Saccharomyces cerevisiae strain, nyob rau hauv uas cov amino acid proline tau hloov nrog aspartic acid. Kev siv cov tshuaj no tuaj yeem them nyiaj rau cov ntshav qab zib mellitus (DM), txo qhov muaj feem ntau ntawm cov teeb meem tshwj xeeb ntawm tus kab mob, lossis ncua lawv qhov kev tsis pom tshwm sim hauv cov neeg muaj keeb kwm.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Cov tshuaj nquag ntawm cov tshuaj (insulin Aspart) yog kev hloov pauv ntawm cov tib neeg cov tshuaj insulin ntawm kev ua kom raug. Tus neeg sawv cev hypoglycemic yog muaj li ob-theem kev daws teeb meem (soluble insulin Aspart thiab cov tshuaj tiv thaiv kab mob muaju) rau cov kab mob hauv lub cev thiab chaw tswj hwm. Ntxiv nrog rau cov nquag tivthaiv, qhov muaj pes tsawg leeg hauv cov tshuaj suav nrog cov khoom siv pabcuam. Saib cov lus hauv qab no yog cov lus qhia ntxiv.

Cov sodium sodium phosphate dihydrate

Cov Sodium hydroxide 2M

Hydrochloric acid 2M

Cov chaw muag tshuaj

Cov tshuaj muaj zog ntawm cov tshuaj cuam tshuam nrog cov receptors ntawm cytoplasmic membrane ntawm cov hlwb, txoj kev ua ib hom insulin receptor complex uas txhawb cov synthesis ntawm ntau cov enzymes tseem ceeb. Cov nyhuv ntawm cov tshuaj yog vim tias cov nqaij ua haujlwm ntau ntxiv cov piam thaj, kev ua rau lub siab ua haujlwm glycogenic.

Hloov cov amino acid nyob rau hauv txoj haujlwm B28 nrog aspartic acid txo qhov nyiam ntawm cov molecules los ua hexamers hauv cov kuab tshuaj ntawm cov tshuaj, uas tau sau tseg nyob rau hauv ntuj hom ntawm cov tshuaj hormones. Vim tias qhov no, qhov nqus ntawm Insulin Aspart los ntawm cov rog subcutaneous tshwm sim sai dua tib neeg. Tom qab txhaj tshuaj, cov nyhuv ntawm hypoglycemia tshwm sim tsis pub dhau 15-20 feeb, nce mus txog nws qhov siab tshaj plaws tom qab 1-3 teev, thiab tom qab 5-6 teev, cov kua nplaum nyob rau nws cov qib qub.

Kev ntsuas rau siv

Insulin Aspart yog tshaj tawm rau cov ntshav qab zib kom tsis muaj zog. Ntawm hom 2 mob ntshav qab zib, cov tshuaj siv thaum tus neeg mob tiav lossis ib feem ntawm qhov tsis hnov mob ntawm insulin receptors rau qhov ncauj hypoglycemic tus neeg sawv cev thaum lub zog sib txuam. Ntxiv rau, cov khoom lag luam pharmacological tau pom zoo rau kev siv los ntawm cov neeg, ntxiv rau cov kab mob hauv qab (ntshav qab zib), tau ntsib cov kev mob sib kis.

Cov lus qhia rau kev siv

Txoj kev siv ntawm cov tshuaj yog subcutaneous txhaj tshuaj. Intramuscular txhaj yog txwv. Cov tshuaj tua kab mob yog tsis tshua muaj rau cov kev qhia tshwj xeeb. Cov tshuaj yuav tsum tau muab rau hauv lub plab phab ntsa, ncej puab lossis pob tw. Koj tuaj yeem siv ib qho analogue ntawm tib neeg insulin ob qho ua ntej thiab tom qab noj mov. Cov koob tshuaj ntawm cov tshuaj tau suav ib tus zuj zus rau txhua tus neeg mob.

Nrog lub raum tsis zoo los yog lub siab ua haujlwm, qhov xav tau rau lub cev tsawg zuj zus, thaum muaj cov kabmob kis nws nce ntxiv, uas yuav tsum muaj kev kho kom haum rau ntawm Insulin Aspart. Qhov kev nqus ntawm cov tshuaj no cuam tshuam nrog cov zaub mov, yog li nws tsim nyog txiav txim siab qhov muaj txiaj ntsig ntawm qhov tshwm sim ntau cov cuam tshuam hauv cov neeg mob noj tshuaj uas ua rau qeeb qeeb ntawm qhov nqus ntawm cov zaub mov. Tom qab them nyiaj rau cov metabolism hauv metabolism, cov neeg mob yuav ntsib lawv cov tsos mob li qub ntawm hypoglycemia, xav tau kev tswj hwm tam sim ntawm kev daws cov piam thaj lossis piam thaj sab hauv.

Cov lus qhia tshwj xeeb

Hauv cov lus qhia rau kev siv, nws tau tshaj tawm tias kev siv tshuaj tsis txaus lossis cuam tshuam ntawm kev kho mob ntshav qab zib tuaj yeem ua rau hyperglycemia, ketoacidosis. Kev siv cov Insulin Aspart Nyob rau qee kis yuav tsum tau muaj kev nce ntau ntxiv ntawm cov neeg txhaj tshuaj tiv thaiv kab mob ntshav qab zib yav tas los. Thaum kho ntshav qab zib nrog cov tshuaj no, yuav tsum tau saib xyuas thaum tsav tsheb thiab koom nrog lwm cov haujlwm txaus ntshai uas yuav tsum muaj kev xav ntau ntxiv thiab ceev ntawm cov kev tiv thaiv psychomotor.

Yeeb tshuaj sib cuam tshuam

Insulin Aspart tsis yog cov tshuaj ua tau zoo nrog lwm cov tshuaj. Kev ua ntawm cov tshuaj yog txhim kho los ntawm qhov ncauj hypoglycemic tshuaj, MAO inhibitors, ACE inhibitors, carbonic anhydrase, sulfonamides, anabolic steroids, tetracyclines, ethanol-muaj cov tshuaj. Cov tshuaj muaj qhov ncauj, thiazide diuretics, heparin, tricyclic cov tshuaj tiv thaiv kab mob, morphine, nicotine thaiv cov kev ua haujlwm hypoglycemic ntawm ob-theem hormone. Nyob rau hauv cawv ntawm salicylates thiab reserpine, ob qho tib si nce thiab qaug zog ntawm kev ua ntawm cov tshuaj tuaj yeem pom.

Phiv thiab haus tshaj

Kev txiav txim los ntawm kev tshuaj xyuas, thaum pib kho nrog cov tshuaj nyob rau hauv nqe lus nug, kev ua txhaum ntawm kev cuam tshuam ntau zaus tshwm sim, uas rau feem ntau yog txoj kev hloov pauv. Tej zaum qhov kev txhim kho ntawm kev ua xua hauv zos nyob rau hauv daim ntawv ntawm hyperemia, khaus ntawm daim tawv nqaij ntawm qhov chaw txhaj tshuaj, tawm pob, o. Muaj qee zaus, muaj cov kev mob tshwm sim feem ntau raug sau tseg: mob taub hau, txo ntshav siab, tachycardia, ua pa nyuaj. Tawm tsam keeb kwm yav dhau los ntawm kev noj ntau dhau ntawm Insulin Aspart, cov kab mob hauv qab no yuav tshwm sim:

ntshav qab zib,
cramps
hypoglycemic coma,
mob neuropathy mob,
hais lus tsis taus
kev nyuaj siab
exacerbation ntawm cov kab mob ntshav qab zib retinopathy,
nce hws.

Cov nqe lus ntawm kev muag khoom thiab kev cia khoom

Lub txee lub neej ntawm cov khoom yog 30 lub hlis txij li hnub ntawm kev tsim khoom. Insulin Aspart yuav tsum tiv thaiv los ntawm kev kub nyhiab ntau dhau ntawm tshav kub thiab lub teeb. Khaws cov noob-hloov kho cov tshuaj hormones ntawm qhov kub ntawm 2-8ºC. Cov tshuaj yuav muag los ntawm cov khw muag tshuaj tshwj xeeb los ntawm cov tshuaj.

Thaum siv txoj kev hloov pauv ob-theem tsis tuaj yeem yog vim tus neeg tsis kam txais ntawm nws cov khoom siv lossis xav tau cov tshuaj pheej yig dua, cov kws kho mob tau muab tshuaj zoo ib yam li Insulin Aspart. Niaj hnub no, cov neeg siv khoom lag luam tau txais kev xaiv loj ntawm hypoglycemic tus neeg sawv cev, tab sis, xaiv cov tshuaj no lossis cov tshuaj, cov tuam txhab tsim los ntawm Asmeskas, Nyiv, thiab Western Europe yuav tsum tau nyiam. Feem ntau, cov analogues hauv qab no yog cov kws kho:

NovoRapid Flexpen,
NovoLog,
NovoRapid Penfill.

Nqe rau Insulin Aspart

Tus nqi nruab nrab ntawm cov tshuaj hauv cov khw muag tshuaj hauv Moscow yog kwv yees li 1700-1800 p. rau ib 3 ml ntawm cov tshuaj hypoglycemic. Tau hais tias kev kho mob ntshav qab zib nrog kev hloov pauv hloov ntshav yuav tsum muaj nuj nqi tseem ceeb, nws yuav tsis yog qhov tseem ceeb rau kev saib xyuas rau cov kev siv Internet tshwj xeeb, qhov twg tus nqi ntawm cov tshuaj muaj qis dua li tau hais hauv khw muag tshuaj.

Olga, 48 xyoo. Kuv tau siv cov tshuaj Insulin Aspart thaum kuv tshawb pom tias cov tshuaj ntshav qab zib tsuas yog tsis ua haujlwm lawm. Cov koob tshuaj txhua hnub ntawm cov tshuaj tau sau tseg los ntawm kws kho mob. Raws li cov lus pom zoo tau txais, Kuv tau qhia 5 chav ntawm kev daws teeb meem ua ntej txhua pluas noj. Ua tsaug rau cov tshuaj, Kuv muaj peev xwm ua kom cov ntshav qabzib ntau nyob rau lub sijhawm luv.

Andrey, 50 xyoo. Tau 3 xyoos kuv tau mob ntshav qab zib txaus decompensated. Tshuaj, noj haus, kev ua neej zoo tsis pab txo qis cov suab thaj hauv cov ntshav, yog li kuv yuav tsum hloov mus rau qhov kev kho tshuaj hormone. Tus kws kho mob qhia kom siv cov tshuaj Insulin Aspart. Kuv txhaj 20 IU ntawm cov tshuaj txhua txhua hnub rau ib hlis, tom qab ntawd tus mob ruaj khov.

Elena, 56 xyoo lawm Kuv tau siv Insulin Aspart tau ib xyoos tam sim no thiab, Kuv yuav tsum lees, Kuv xav zoo heev. Ua ntej rau qhov no, Kuv tau ntsib qhov tsis muaj zog, qhov mob nqaij. Lub sijhawm no kuv qhia 14 units ntawm cov tshuaj thoob plaws ib hnub. Nyob rau tib lub sijhawm, Kuv nruj me ntsis saib xyuas cov kev hloov pauv ntawm kuv kev ua neej nyob ib txwm, ntawm kev coj ua uas kuv kho txhua hnub ntau npaum li cas ntawm cov tshuaj.

Hais txog yeeb tshuaj

Nws yog tshuaj kho kom txo tau cov concentration ntawm dextrose hauv ntshav.

Txo cov kua nplaum pib los ntawm kev txhim kho nws txoj kev nqus los ntawm cov ntaub so ntswg. Cov tshuaj maj mam txo cov nqi ntawm cov piam thaj hauv lub siab thiab txhim kho kev zom zaub mov hauv lub cev.

Ib leeg kho ib theem rau cov neeg mob ntshav qab zib hom 1.

Aspartum biphasic insulin kuj tseem raug sau tseg rau mob ntshav qab zib hom 2, yog tias muaj tshuaj tiv thaiv kab mob rau cov kab mob ntshav qab zib.

Qhov kev nqis tes ntawm ib-tus neeg sawv cev tsuas yog luv luv. Nws tshwm sim 10-20 feeb tom qab thov. Lub sijhawm raug ntev li 5 teev.

Kev ua ob-ntu - txog ib hnub. Kev kho mob tshwm sim tom qab 10 feeb, vim tias nws muaj cov tshuaj hormones ntawm luv thiab nruab nrab kev ua.

Daim ntawv thov nta

Cov tshuaj Insulin Bifaxicum thiab Aspart yog tawm tsam cov neeg mob hnub nyoog qis dua 6 xyoo. Cov kev tshawb fawb txog cov nyhuv ntawm cov tshuaj rau cov menyuam yaus lub cev tsis tau ua. Cov kws kho mob tsis paub txog cov tshuaj yuav cuam tshuam li cas rau cov mob ntawm tus menyuam.

Peb muab cov luv nqi rau cov nyeem ntawm peb lub xaib!

Kev noj tshuaj thaum lactation tsis txwv. Kev siv raug tso cai yog tias muaj kev pheej hmoo rau tus menyuam tsawg dua li txiaj ntsig rau leej niam.

Raws li rau cov neeg mob laus, nws yog ib qho tsim nyog yuav tau kho qhov koob tshuaj. Cov hnub nyoog pauv hauv lub cev tuaj yeem ua rau tsis muaj mob tsis zoo. Txij li thaum ua haujlwm ntawm cov nruab nrog sab hauv nruab nrog muaj kev cuam tshuam, qhov kev txiav txim ntawm tus mob ntshav qab zib hauv lub siab ua rau muaj mob.

Kev cuam tshuam nrog lwm yam tshuaj

Cov tshuaj uas txo cov ntshav qab zib, uas noj hauv qhov ncauj, txhim kho kev ua ntawm cov tshuaj tiv thaiv. Cov tshuaj no tsis pom zoo. Kev mob ntshav qab zib yog nce zuj zus, ib qho tshwm sim los ntawm tsawg dua cov piam thaj hauv qab cov txiaj ntsig.

Anabolic steroids, Ketoconazole, Pyridoxine thiab lwm yam tshuaj raws li ethanol thiab tetracyclines, uas siv ib txhij nrog cov tshuaj hypoglycemic no, kuj tseem ua rau cov ntshav qabzib tsawg.

Qhov kev tiv thaiv kab mob hauv lub cev, tshuaj heparin thiab tshuaj tiv thaiv kab mob siv rau hauv cov ntshav qab zib mellitus los txo qis cov tsos mob ntawm kev ua phem tuaj yeem txo qhov tshwm sim ntawm cov tshuaj.