Baeta rau kev kho mob ntawm hom 2 mob ntshav qab zib

Txij li tsab xov xwm hais txog cov tshuaj tau tshwm sim hauv peb lub vev xaib "Baeta", uas yog siv rau hauv kev kho mob ntawm hom 2 mob ntshav qab zib, ntau tshaj li ib xyoos tau dhau los. Lub sijhawm no, "Baeta" tau txais qee yam muaj koob npe nyob hauv thaj chaw ntawm lub teb chaws ntawm USSR qub thiab muaj kev yoojyim rau cov neeg mob ntshav qab zib.

Niaj hnub no peb yuav tham txog cov tshuaj no kom paub meej ntxiv, xav txog keeb kwm ntawm qhov kev tsim kho nws thiaj li nkag siab txog qhov nws cuam tshuam rau lub cev ntawm cov ntshav qab zib, nws txawv li cas ntawm lwm cov tshuaj, yuav ua li cas nws tuaj yeem siv tau thiab muaj kev phem dab tsi tuaj yeem ua rau.

Hauv North America, ib hom tsiaj tshwj xeeb ntawm kev muaj av nyob, uas tsuas pub 3-4 zaug hauv ib xyoos. Nyob rau tib lub sijhawm, lawv haus cov khoom noj ntau heev - txog li ib feem peb ntawm lawv qhov kev hnyav tag nrho.

Them sai sai rau qhov xwm txheej no txawv ntawm cov tsiaj qus, cov kws tshawb fawb Asmeskas tau pom tias cov qaub ncaug ntawm tus tsiaj no muaj cov tshuaj yeeb dej caw exendinCov. Thaum lizards nkag mus rau cov hnyuv thiab cov ntshav ncig exendin ua rau kom muaj kev faib khoom noj ntawm lub sijhawm ntev mus. Ntawd yog, khoom noj yog nqus tau qeeb heev, uas yog vim li cas xws li cov sijhawm tsawg kawg ntawm tsiaj yug tsiaj tau tshwm sim los.

Ua tsaug rau cov kev hloov kho uas cov qaub ncaug ntawm cov tsiaj no tau raug mob, Bayeta tshuaj tau tshwm sim, nrog rau cov tshuaj nquag exenatide.
Qhov peculiarity ntawm kev kho mob hauv kev kho mob ntshav qab zib hom 2 yog tias nws pab txo tus neeg mob lub cev qhov hnyav. Thaum cov tshuaj feem ntau siv rau tib lub hom phiaj ua rau qhov kev tsis sib haum xeeb.

Yog tias koj xav hais tias ib qho ntawm cov ua rau tus kab mob no yog tus neeg rog thiab rog dhau, ces siv cov ntshav qab zib hom 2 tuaj yeem txiav txim siab ua qhov kev daws teeb meem rau ob qho teeb meem nyob rau tib lub sijhawm.

Raws li kev txheeb xyuas thiab cov ntawv tshaj tawm ntau yam, byte siv ob zaug ib hnub. Hauv qhov no, insulin tsis siv. Tab sis kev kho mob ntshav qab zib hom 2 sib xyaw nrog kev siv qee yam tshuaj ntxiv.
Cov lus qhia ntawm cov tshuaj byte yog nqa tawm hauv tus ncej puab, sab caj npab los yog lub plab, hauv cov rog rog subcutaneous. Ib tug xaum xaum li niaj zaus siv rau qhov no.

Tsuas siv tau los kho tus mob ntshav qab zib hom 2 xwb. Nws tsis pom zoo kom siv cov tshuaj nyob rau hauv muaj cov kab mob xws li mob ntshav qab zib ketocidosis, lub raum tsis ua haujlwm, ntau yam kab mob plab, thiab nce rhiab rau ntau yam ntawm cov tshuaj.

Bayeta tsis tuaj yeem raug txwv rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, siv thaum cev xeeb tub thiab thaum pub niam mis.

Muaj ib qho kev qhia.

Cov tshuaj raug muab rau 1 teev ua ntej noj mov, 2 zaug ib hnub. Cov tshuaj noj, nws txo qis lossis nce siab yog pom zoo nrog tus kws kho mob tham.

Koj tsis tuaj yeem siv chav dej yog tias qhov kev daws teeb meem zoo li huab, ntau qhov sib txuam tau pom hauv nws lossis nws muaj xim xaj xaj. Nws tsis pom zoo kom siv tam sim ntawd tom qab noj mov. Kev txiav txim siab intramuscular thiab intravenous ntawm byte tov yog tsis suav tias yog.

Thaum siv ntau yam tshuaj tua kab mob, lawv yuav tsum tau noj ib teev ua ntej ua haujlwm ntawm cov tshuaj byte.

Ua ntej siv cov tshuaj Baeta rau kev kho mob ntawm hom 2 mob ntshav qab zib, koj yuav tsum sib tham nrog kws kho mob!

Lub Npe Tsis Muaj Npe International

INN Bayeta - Exenatide.

Baeta yog ib tus neeg sawv cev hypoglycemic tsim los kho hom mob ntshav qab zib hom II, muaj cov tshuaj lag luam zoo heev.

Cov tshuaj yog zwm rau pharmacological pawg ntawm hluavtaws hypoglycemic cov neeg sawv cev npaj rau kev kho mob ntawm insulin-dependant ntshav qab zib mellitus, thiab muaj ATX code ntawm A10X.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj tov siv rau kev tswj hwm subcutaneous. Nws yog cov kua ntshiab, tsis muaj xim thiab tsw. Nws cov tshuaj tshaj tawm exenatide muaj qhov kub siab ntawm 250 μg rau 1 ml ntawm kev daws. Lub luag haujlwm ntawm cov kuab tshuaj yog ua si los ntawm kev txhaj tshuaj dej, thiab cov pabcuam pabcuam yog sawv cev los ntawm metacresol, sodium acetate trihydrate, acetic acid thiab mannitol (ntxiv rau E421).

Ib qho kev daws teeb meem ntawm 1.2 lossis 2.4 ml yog nchuav rau hauv daim iav iav, txhua tus tau muab tso rau hauv cov ntawv xuav pov tseg - qhov sib piv ntawm cov tshuaj insulin. Cov thawv ntim khoom. Tsuas muaj 1 rab koob tshuaj muaj tshuaj nyob hauv lub thawv.

Daim ntawv tso tawm ntev ntev uas muaj npaj muaj nyob hauv cov hmoov uas yog npaj rau kev sib xyaw lub txim. Cov kua dej hauv lub cev tseem siv rau kev txhaj tshuaj subcutaneous. Cov tshuaj yeeb tshuaj (2 mg) yog nchuav rau hauv lub thawv ntawv uas tau muab tso rau hauv rab koob xaum qhuav. Cov khoom siv nrog cov tshuaj tiv thaiv thiab cov lus qhia.

Bayeta yog cov iav cartridge nrog cov tshuaj ua kom haum rau kev tswj hwm subcutaneous, muab tso rau hauv cov koob txhaj tshuaj pov tseg.

Pharmacological kev txiav txim

Cov nyhuv ntawm cov tshuaj yog muab los ntawm kev ua ntawm exenatide (exendin-4).

Qhov sib txuas ua ke no yog cov amino peptide saw nrog 39 amino acid ntsiab.

Cov tshuaj no yog cov qauv ua qauv ntawm enteroglucagon, peptide hormone ntawm cov chav kawm ntau zuj zus hauv tib neeg lub cev, uas tseem hu ua glucagon-zoo li peptide-1, lossis GLP-1.

Tus incretins yog tsim los ntawm cov hlwb ntawm lub txiav thiab hnyuv tom qab noj mov. Lawv qhov ua haujlwm yog pib cov tshuaj insulin zais cia. Vim tias nws zoo sib xws nrog cov tshuaj hormonal, exenatide muaj tib lub cev. Ua raws li GLP-1 lub ntsej muag, nws ua kom pom cov khoom hauv qab no:

txhim kho kev tso tawm ntawm cov tshuaj insulin los ntawm pancreatic cells-hlwb nrog kev nce ntxiv ntawm cov ntshav piam thaj hauv siab,
txo cov pa glucagon tso zis ntau dhau, tsis muaj dab tsi cuam tshuam rau cov lus teb rau hypoglycemia,
inhibits lub cev muaj zog ntawm lub plab, ua rau qeeb ntawm nws lub cev,
tswj kev qab los noj mov
txo tus nqi ntawm cov zaub mov noj,
txhawb nqa poob.

Cov lus qhia Byetta - aplikace Hom 2 mob ntshav qab zib hauv cov ntsiab lus yooj yim

Ntawm hom 2 Ntshav Qab Zib, pancreatic function-cell muaj qhov ua haujlwm tsis zoo, uas ua rau muaj insulin secretion. Exenatide cuam tshuam rau ob theem ntawm cov kua dej tso pa tawm. Tab sis tib lub sijhawm, qhov kev siv ntau ntawm kev ua haujlwm ntawm β-hlwb pib los ntawm nws txo nrog kev txo qis hauv cov piam thaj. Qhov kev nqus ntawm cov insulin nres thaum lub sijhawm thaum glycemic Performance index rov qab zoo li qub. Yog li, kev qhia txog cov tshuaj nyob rau hauv nqe lus nug txo qhov zoo li ntawm kev txhim kho hypoglycemia.

Cov kev tshawb fawb pom tau hais tias kev kho mob ua rau kev tswj ntshav qab zib tau zoo hauv cov neeg mob ntshav qab zib hom 2.

Cov Tshuaj Pharmacokinetics

Tom qab tswj hwm ntawm Baeta nyob rau hauv txoj kev txhaj tshuaj subcutaneous, cov tshuaj pib yuav nqus mus rau hauv cov ntshav, nce mus txog qib siab ntawm kev saturation hauv kwv yees li 2 teev.

Tag nrho qhov kev xav ntawm exenatide nce rau hauv kev faib ua feem rau cov koob tshuaj uas tau txais nyob hauv thaj tsam ntawm 5-10 μg.

Cov tshuaj Baeta tau mus txog nws qhov kev siab tshaj plaws nyob rau hauv cov ntshav 2 teev tom qab ua haujlwm subcutaneous thiab raug tshem tawm ntawm lub cev tsis pub dhau 10 teev.

Kev pom ntawm cov tshuaj yog nqa tawm los ntawm cov hlab ntsha hauv lub raum, cov tshuaj tiv thaiv proteolytic enzymes tau koom nrog hauv nws qhov kev hloov kho. Nws yuav siv li 5 teev los tshem tawm cov tshuaj feem ntau ntawm lub cev, tsis hais txog kev siv ntau npaum li cas. Kev ua kom tiav ntawm lub cev ua tiav yuav siv 10 teev.

Kev ntsuas rau siv

Cov tshuaj tau qhia rau kev kho glycemic txaus hauv kev tsim tshuaj insulin-mob ntshav qab zib. Byetu tuaj yeem raug siv los ua tshuaj hypoglycemic rau kev kho mob monotherapy. Xws li kev txhaj tshuaj muaj txiaj ntsig zoo yog tias muaj cov khoom noj zoo tsim nyog thiab ua raws li cov kev kho mob ib txwm ua.

Cov tshuaj no tuaj yeem suav nrog hauv kev kawm ua ke nrog kev ua haujlwm tsis txaus ntawm kev kho mob nrog lwm tus neeg sawv cev antiglycemic. Ntau hom tshuaj sib xyaw ua ke nrog Bayeta raug tso cai:

Sulfonylurea derivative (PSM) thiab Metformin.
Metformin thiab Thiazolidinedione.
PSM nrog Thiazolidinedione thiab Metformin.

Cov tswv yim zoo li no ua rau txo qis rau cov ntshav qab zib thiab tom qab noj mov, nrog rau glycemic hemoglobin, uas txhim kho glycemic tswj cov neeg mob.

Bayeta yog qhov tsim nyog kho kho glycemic txaus, thiab nws kuj tseem siv tau rau kev kho mob monotherapy.

Cov Yuav Tsum Muaj

Cov tshuaj tsis tuaj yeem siv rau hom ntshav qab zib hom 1. Lwm yam contraindications:

muaj qhov ntxim nyiam ua kom yooj yim tshaj plaws,
intolerance mus rau pab additives,
ketoacidosis
kev puas tsuaj rau cov zom plab, nrog los ntawm kev txo qis hauv txoj kev sib cog lus ntawm lub plab zom mov
pub niam mis los yog cev xeeb tub,
mob raum tsis ua haujlwm
hnub nyoog txog 18 xyoo.

Kev pub niam mis yog ib qho ntawm kev tsis pom zoo rau kev siv tshuaj Bayet.

Yuav ua li cas noj bayetu?

Tus kws kho mob muaj lub luag haujlwm sau tshuaj, txiav txim siab pom tias pom zoo tshaj plaws thiab saib xyuas tus neeg mob ntshav qab zib. Nws raug nquahu tias koj yuav tsum tsis txhob tus kheej-kev noj tshuaj.

Qhov hno tau muab tso rau hauv qab daim tawv nqaij hauv thaj chaw mos, nqaij mos lossis plab. Qhov chaw txhaj tshuaj ntawm cov tshuaj tsis cuam tshuam rau nws qhov kev ua tau zoo.

Thaum xub thawj, ib zaug tshuaj tsuas yog 0.005 mg (5 μg). Kev txhaj tshuaj yog muab ua ntej noj tshais thiab noj hmo. Qhov sib txawv ib ntus nruab nrab ntawm kev qhia ntawm cov tshuaj thiab pib noj mov yuav tsum tsis txhob ntau dua 1 teev.

Nruab nrab ntawm cov zaub mov tseem ceeb, uas cuam tshuam nrog kev siv tshuaj, tsawg kawg 6 teev yuav tsum hla.

Tom qab ib hlis kho, ib koob tshuaj ib zaug tuaj yeem ua ob npaug. Txoj kev ncua tsis mus txhaj tsis tau txais txiaj ntsig ntxiv nrog kev siv tshuaj txuas ntxiv. Tom qab noj Bayetu yuav tsum tsis txhob pricked.

Nrog rau thaum uas tig mus siv cov tshuaj hauv cov nqe lus nug nrog kev npaj sulfonylurea, tus kws kho mob tuaj yeem txo qhov ntau npaum ntawm qhov tom kawg vim tias muaj qhov tshwm sim rau kev txhim kho ntawm cov tshuaj tiv thaiv hypoglycemic. Kev kho ua ke nrog Thiazolidinedione thiab / lossis Metformin tsis tas yuav muaj kev hloov pauv ntawm cov tshuaj thawj zaug ntawm cov tshuaj no.

Sab sij huam

Cov kev phiv tshuaj uas tshwm sim los ntawm exenatide muaj qhov mob nyhav ib nrab thiab tsis tas yuav tsum tsis txiav tawm cov tshuaj (muaj qhov tsis tshua pom). Feem ntau feem ntau, thaum pib ntawm kev kho mob nrog Bayeta nrog kev noj tshuaj 5 mg lossis 10 mg, xeev siab tshwm sim, uas ploj lawm nws tus kheej lossis tom qab kho qhov tshuaj kho.

Xeev siab yog qhov tshwm sim tsis zoo rau kev nqis tes ua ntawm cov tshuaj Bayet, feem ntau tshwm sim thaum pib ntawm kev kho mob.

Lub plab zom mov

Feem ntau, cov neeg mob ua kom lub plab zom mov. Cov neeg mob yws yws, tsis hnov qab, tsis qab los, ntuav, ua tsis taus pa, mob hauv plab. Qhov tsim nyog tsis kam rov qab, qhov tshwm sim ntawm txoj kev sib, pom pob zom, quav tawv, ua txhaum cai ntawm kev saj. Ntau qhov tshwm sim ntawm tus mob pancreatitis tau sau tseg.

Nruab nrab hauv lub paj hlwb

Feem ntau cov neeg mob muaj mob yastaw. Lawv yuav zoo li kiv taub hau lossis hnov zoo li tsaug zog thaum nruab hnub.

Cov migraines yog ib qho kev mob tshwm sim tshwm sim los ntawm kev siv tshuaj Bayet los ntawm cov hlab ntsha hauv nruab nrab.
Raws li kev siv tshuaj Bayeta, cov neeg mob yuav zoo li kiv taub hau.
Kev tawm tsam thaum nruab hnub pw tsaug zog yog muaj kev phiv los ntawm kev siv Byeta.

Ntawm ib sab ntawm daim tawv nqaij

Ntawm qhov chaw txhaj tshuaj, cov cim focal tuaj yeem pom.

Kev ua xua muaj peev xwm ua tau rau hauv daim ntawv ntawm daim tawv nqaij ua pob, khaus, liab, liab. Kev tsis pom qhov tsis zoo yog tsis tshua pom muaj.

Cov tawv nqaij khaus yog qhov tshwm sim tsis haum rau kev siv tshuaj Bayet.

Cov lus qhia tshwj xeeb

Yog tias cov xim, pob tshab lossis kev sib thooj ntawm cov kua txhaj tshuaj tau hloov, nws tsis tuaj yeem siv. Koj yuav tsum ua raws li txoj kev pom zoo ntawm kev tswj hwm tshuaj. Kev txhaj tshuaj tsis yog muab rau cov tshuaj los yog ua kom nqaij los ntshav.

Kev ntsuas tsis zoo los ntawm kev qab los lossis qhov poob ntawm tus neeg mob tsis yog qhov tseem ceeb rau kev txiav luam yeeb tshuaj, kev hloov pauv hauv nws cov ntau npaum li cas thiab kev siv ntau npaum li cas.

Hauv kev teb rau kev qhia tawm ntawm exenatide, cov tshuaj tiv thaiv tuaj yeem tsim nyob rau hauv lub cev. Qhov no tsis cuam tshuam qhov tshwm sim ntawm cov tsos mob tshwm sim.

Siv rau lub sijhawm qub

Lub chaw muag tshuaj ntawm cov tshuaj tsis yog nyob ntawm lub hnub nyoog ntawm cov neeg mob. Yog li, tsis tas yuav siv tshuaj ntau rau cov neeg laus.

Cov hnub nyoog laus tsis yog contraindication rau kev siv tshuaj Bayet, thiab kuj tsis tas yuav kho qhov tshuaj ntau npaum li cas.

Daim ntawv thov rau lub siab ua haujlwm tsis zoo

Vim tias qhov tseeb hais tias lub nra tseem ceeb rau kev tshem tawm exenatide ntog rau ob lub raum, malfunctions ntawm daim siab los yog lub zais zis ua haujlwm tsis yog qhov kev tsis sib haum rau kev siv tshuaj thiab tsis ua kom txwv.

Ua tsis tiav rau hauv daim siab lossis lub zais zis hauv plab tsis yog qhov sib tshooj rau kev siv tshuaj.

Noj ntau dua ntawm Byeta

Kev muaj zog dhau ntawm cov tshuaj pom zoo ntawm exenatide ua rau cov ntshav qab zib tsawg. Hauv qhov no, txhaj tshuaj los yog kua dej ntawm qabzib yog yuav tsum muaj. Cov tsos mob ntawm kev overdose:

bouts ntawm xeev siab
ntuav
ntshav qab zib tsawg tsawg
pallor ntawm integument,
ua daus no
mob taub hau
hws
arrhythmia,
kev tshee
nce nyob rau hauv cov ntshav siab:
tshee hnyo.

Arrhythmia yog ib qho ntawm cov tsos mob ntawm kev overdose ntawm Bayet.

Kev cuam tshuam nrog lwm yam tshuaj

Kev sib tov nrog lwm cov tshuaj nyob hauv 1 koob txhaj tshuaj yog txwv.

Koj yuav tsum coj mus rau hauv kev qeeb ntawm lub plab hauv qab qhov kev ua ntawm exenatide thaum noj tshuaj sab hauv, vim hais tias cov neeg kawm ntawv qib siab thiab nqus tau tuaj yeem txo qis heev. Cov nyiaj no yuav tsum tau siv sijhawm ntev ua ntej kev qhia ntawm Byeta, lub sijhawm tsawg kawg yog 1 teev. Yog tias cov tshuaj yuav tsum noj nrog zaub mov noj, ces nws yuav tsum yog cov pluas noj tsis cuam tshuam nrog kev txhaj tshuaj ntawm tus neeg sawv cev hypoglycemic no.

Proton twj tso kua mis inhibitors yuav tsum noj 4 teev tom qab txhaj tshuaj lossis 1 teev ua ntej nws.

Nrog rau kev siv cov tshuaj warfarin los yog lwm yam kev npaj noj haus marmarin, qhov nce ntawm lub sijhawm prothrombin yog ua tau. Yog li, ntshav coagulation yuav tsum tau tswj.

Txawm hais tias kev sib xyaw ua ke ntawm Bajeta nrog rau cov tshuaj uas tiv thaiv HMG-CoA reductase tsis ua rau muaj kev hloov pauv tseem ceeb hauv cov ntshav lipid, nws pom zoo kom soj ntsuam cov roj cholesterol.

Kev sib xyaw ntawm cov tshuaj hauv cov lus nug nrog Lisinopril tsis ua rau muaj kev hloov pauv hauv cov ntshav nruab nrab hauv tus neeg mob.

Sib txuas kev txhaj tshuaj ntawm Bajeta nrog tshuaj tiv thaiv qhov ncauj tsis tas yuav hloov pauv tshuaj.

Nws tsis yog yuav tsum tau soj ntsuam ib qho tshwj xeeb sib xyaw ntawm Bayeta kev txhaj tshuaj thiab kev noj tshuaj - tshuaj ntsuab ntawm sulfanylurea.

Nrog kev sib txuas / ua ke tswj hwm ntawm Bayeta nrog Warfarin, nws yog qhov tsim nyog los tswj ntshav coagulation.

Cawv tau zoo

Nws yog qhov tsis tsim nyog txog kev haus cawv los yog tshuaj rau cawv thaum kho.

Tsuas muaj 2 qho tiav ntawm cov tshuaj - Exenatide thiab Baeta Ntev. Cov kab mob hypoglycemic hauv qab no muaj cov nyhuv zoo sib xws:

Generic Baeta - Bydureon (Bydureon).

Victoza yog ib tus neeg sawv cev hypoglycemic uas muaj cov duab zoo sib xws nrog Bayeta.

Hnub tas sij hawm

Hauv nws daim ntawv qub, cov tshuaj muab cia rau 2 xyoos. Tom qab qhib lub pob, nws yuav tsum siv hauv 30 hnub.

Lub txee lub neej ntawm cov tshuaj Bayeta yog 2 xyoos nyob rau hauv nws daim ntawv qub thiab 30 hnub tom qab qhib lub pob.

Chaw tsim tshuaj paus

Tshaj tawm lub teb chaws ntawm keeb kwm yog Great Britain. Txawm li cas los xij, kev tsim cov tshuaj yog nqa tawm los ntawm Indian chaw lag luam kws tshuaj Macleods Pharmaceuticals Ltd.

Alla, 29 xyoos, Stavropol.

Yuav Baitu niam. Kim kim, tab sis yooj yim siv. Thaum xub thawj, leej niam yws yws tias nws tsis xeev siab, tab sis tsis ntev nws cia li tsum.Qab zib yog qhov ruaj khov, yog li peb yuav siv cov tshuaj txuas ntxiv mus.

Veronika, 34 xyoo, Danilov.

Thaum kuv rov nyeem cov lus qhia, Kuv xav tias tsis yooj yim los ntawm daim ntawv teev cov kev mob tshwm sim. Tom qab kev txhaj tshuaj Kuv tau mob. Kuv kuj tau ntshai los saib xyuas cov tshuaj tom ntej. Tab sis kuv tus txiv hais tias kuv tau khib kuv tus kheej. Nws hais yog lawm. Thaum txhaj ntxiv lawm tsis muaj kev mob siab ntxiv lawm. Tus kws kho mob tau hais tias ntau npaum li cas yuav tsum tsis txhob faib, thiab tom qab ntawd txawm nce ntxiv. Tam sim no nws tsis hnov mob ntxiv lawm, tsuas yog qee zaum muaj kev tsis xis nyob hauv plab.

Olga, 51 xyoo, lub nroog Azov.

Kuv pib siv tshuaj kom pab Metformin. Nws noj dhau thawj hnub dhau ntawm qhov muaj zog - nws qhov qab los noj mov yuav luag ploj mus. Tom qab ntawd lub cev yoog. Cov ntu tau ua me me, tab sis qab los noj mov tau rov qab. Tam sim no nws meej meej vim li cas hauv Asmeskas Bayetu tau raug tshaj tawm rau cov neeg uas xav poob phaus.

Kev Sib Sau thiab daim ntawv ntawm kev tso tawm

Tshuaj Subcutaneous	1 ml
exenatide	250 mcg
tus zam: sodium acetate trihydrate, glacial acetic acid, mannitol, metacresol, dej d / thiab

nyob rau hauv cov ntawv xaum xaum nrog daim cartridges ntawm 1.2 lossis 2.4 ml, hauv ib pob ntawv los ntawm cardboard 1 syringe cwj mem.

Cov Tshuaj Hauv Tshuaj

Exenatide (Exendin-4) yog qhov ua kom zoo ntxiv thiab yog 39-amino acid amidopeptide. Cov ntau zuj zus, xws li cov glucagon-zoo li peptide-1 (GLP-1), txhim kho cov kua dej tsis txaus rau cov kua dej, txhim kho beta ntawm tes ua haujlwm, txwv tsis pub muaj ntshav qabzib ntau thiab ua rau lub plab zom mov tom qab lawv nkag mus rau hauv cov ntshav tawm ntawm txoj hnyuv. Exenatide yog lub zog loj zuj zus uas ua rau cov ntshav qabzib-insulin muaj peev xwm ua rau muaj cov ntshav qabzib ntau yam thiab muaj lwm yam teebmeem ntshav qabzib ntau ntxiv rau cov neeg mob ntshav qab zib hom 2.

Cov amino acid sib lawv liag ntawm exenatide ib nrab sib raug rau ntu ntawm tib neeg GLP-1, los ntawm qhov uas nws khi thiab ua rau GLP-1 cov neeg txais kev pabcuam hauv tib neeg, uas ua rau muaj kev sib txuas ntxiv rau cov piam thaj thiab kev tso ntshav ntawm insulin los ntawm pancreatic beta hlwb nrog kev koom tes ntawm cyclic adenosine monophosphate (AMP) thiab / lossis lwm txoj kev taw qhia kev rau sab kev kawm. Exenatide txhawb kev tso tawm ntawm insulin los ntawm beta hlwb nyob ib puag ncig ntawm kev nce siab nyob hauv siab.

Exenatide sib txawv hauv cov qauv tshuaj thiab cov tshuaj pharmacological los ntawm insulin, sulfonylurea derivatives, D-phenylalanine derivatives thiab meglitinides, biguanides, thiazolidinediones thiab alpha-glucosidase inhibitors.

Exenatide txhim kho glycemic tswj nyob rau hauv cov neeg mob uas muaj ntshav qab zib hom 2 vim yog cov tshuab hauv qab no.

Hauv hyperglycemic tej yam kev mob, exenatide ua rau cov piam thaj tsis muaj peev xwm tso cov kua dej ntawm cov kua dej los ntawm pancreatic beta hlwb. Qhov insulin secretion tso tseg thaum cov concentration ntawm cov piam thaj hauv cov ntshav txo qis thiab nws nce mus rau qhov qub, yog li txo cov kev pheej hmoo ntawm cov ntshav qog ntshav qab zib.

Cov tshuaj insulin tso tawm thaum thawj 10 feeb, hu ua "thawj theem ntawm cov tshuaj insulin", tshwj xeeb tshaj yog qhaj ntawv ntawm cov neeg mob ntshav qab zib hom 2. Tsis tas li ntawd, qhov poob ntawm thawj theem ntawm cov tshuaj insulin yog ib qho kev ua tsis tiav ntawm beta cell ua haujlwm hauv ntshav qab zib hom 2. rov qab los yog ua kom zoo ntxiv rau theem ob thiab theem ob ntawm kev muaj tshuaj insulin hauv cov neeg mob uas muaj ntshav qab zib hom 2.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus tawm tsam keeb kwm ntawm hyperglycemia, kev coj noj coj ua ntawm exenatide txwv kev tso cia ntau dhau ntawm glucagon. Txawm li cas los xij, exenatide tsis cuam tshuam rau lub cev glucagon teb li cas rau kev mob ntshav qab zib.

Nws tau pom tias kev coj noj coj ua ntawm exenatide ua rau kev poob qis thiab ua kom tsawg dua ntawm txoj kev noj zaub mov, inhibits lub cev muaj zog ntawm lub plab, uas ua rau lub qeeb ntawm nws qhov khoob.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, kev kho mob exenatide nrog kev sib xyaw nrog metformin thiab / lossis sulfonylurea kev npaj ua rau txo qis ntshav qabzib, ntshav qabzib tom qab, thiab glycosylated hemoglobin index (HbA1c), thiaj li txhim kho glycemic tswj hauv cov neeg mob no.

Tsuas tshuaj thiab tswj hwm

S / c rau tus ncej puab, plab, lossis caj npab.

Thawj koob tshuaj yog 5 mcg, uas tau txhaj tshuaj 2 zaug / hnub thaum txhua lub sijhawm 60-feeb ua ntej noj thaum sawv ntxov thiab yav tsaus ntuj noj mov. Tsis txhob noj cov tshuaj tom qab noj mov. Yog tias kev txhaj tshuaj tsis tiav, kev kho mob mus txuas ntxiv yam tsis hloov pauv koob tshuaj.

1 lub hlis tom qab pib txoj kev kho mob, cov koob tshuaj yuav raug nce ntxiv rau 10 mcg 2 zaug / hnub.

Thaum ua ke nrog metformin, thiazolidinedione, lossis nrog kev sib xyaw ntawm cov tshuaj no, cov koob tshuaj thawj zaug ntawm metformin thiab / lossis thiazolidinedione tsis tuaj yeem hloov pauv. Thaum muaj kev sib xyaw ntawm Bayeta ® nrog sulfonylurea derivatives, yuav tsum tau txo koob tshuaj sulfonylurea derivative kom txo qis kev pheej hmoo ntawm hypoglycemia.

Dosage thiab txoj hauv kev ntawm kev tswj hwm tshuaj BAETA

Kev hno cov tshuaj yog tsim s / c hauv plab, ncej puab, xub pwg.

Thawj qhov tshuaj yog 5 mcg, noj ob zaug ib hnub, rau 60 feeb ua ntej noj tshais thiab noj hmo. Tom qab noj mov, cov tshuaj tsis pom zoo. Yog tias qhov kev txhaj tsis tiav, tsis txhob ntxiv ob zaug tshuaj noj thaum ua haujlwm tom qab.

Qhov ntau dua cov tshuaj tau nce nyob hauv ib hlis mus rau 10 mcg ob zaug ib hnub.

Ntshav qab zib Hom 2: monotherapy lossis ib qho ntxiv rau kev kho mob nrog metformin, sulfonylurea thiab thiazolidinedione tshuaj nrog glycemic tswj kev ua haujlwm tsis muaj txiaj ntsig.