Gliclazide MV > Kev khomob thiab kev tiv thaiv

Gliclazide MV: cov lus qhia rau kev siv thiab tshuaj xyuas

Lub npe Latin: Gliclazide MV

ATX Code: A10BB09

Tus nquag ua hauj lwm: gliclazide (gliclazide)

Cov neeg tsim khoom: LLC Ozon, LLC Atoll (Russia)

Hloov kho cov lus piav qhia thiab yees duab: 01/14/2018

Cov nqi hauv khw muag tshuaj: los ntawm 81 rubles.

Gliclazide MV yog ib qhov ncauj tshuaj hypoglycemic.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Gliclazide MV yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog hloov kho tso tawm: cylindrical, biconvex, dawb nrog cream zas lossis dawb, me ntsis marbling yog ua tau (10, 20 lossis 30 daim hauv contour aluminium lossis polyvinyl chloride cell pob, 1, 2, 3, 4, 5, 6, 10 pob hauv ib daim ntawv cardboard, 10, 20, 30, 40, 50, 60, lossis 100 pcs. Hauv cov kaus poom yas, 1 tuaj yeem hauv ib daim ntawv cardboard.

Cov muaj pes tsawg leeg ntawm 1 ntsiav tshuaj suav nrog:

Cov tshuaj nquag: gliclazide - 30 mg,
Cov khoom siv pabcuam: hypromellose - 70 mg, colloidal silicon dioxide - 1 mg, microcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Cov Tshuaj Hauv Tshuaj

Glyclazide yog sulfonylurea derivative uas muaj cov khoom hypoglycemic thiab yog rau cov thawj coj hauv qhov ncauj. Nws qhov sib txawv ntawm cov tshuaj hauv pawg no yog muaj lub nplhaib N-muaj cov heterocyclic uas muaj cov kab mob endocyclic.

Gliclazide txo cov ntshav qabzib, yog ua ib lub zog ntawm insulin ntau lawm los ntawm beta hlwb ntawm islets ntawm Langerhans. Qhov kev nce siab ntawm C-peptide thiab cov tshuaj insulin tom qab muaj sia nyob ntev tom qab 2 xyoos ntawm kev kho mob. Xws li lwm yam sulfonylurea derivatives, cov nyhuv no yog vim muaj cov tshuaj tiv thaiv ntau dhau ntawm β-cov hlwb ntawm cov islets ntawm Langerhans mus rau cov kua nplaum tawm, ua raws li hom physiological. Gliclazide tsis yog cuam tshuam rau cov khoom noj metabolism xwb, tab sis kuj cuam tshuam cov teeb meem hemovascular.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus, gliclazide pab ua kom rov zoo li thaum kawg ntawm insulin ntau lawm, uas yog ib qho txiaj ntsig ntawm cov piam thaj thiab ua rau lub zog thib ob ntawm insulin secretion. Ib qho nce ntxiv hauv insulin synthesis yog txuam nrog cov lus teb rau kev ua kom mob los ntawm cov piam thaj lossis zaub mov noj.

Kev siv cov gliclazide txo txoj kev pheej hmoo ntawm kev tsim cov ntshav me me kom tsis muaj zog, ua rau cov txheej txheem uas tuaj yeem ua rau kev txhim kho ntawm cov kev mob tshwm sim hauv cov neeg mob ntshav qab zib mellitus, txo qis cov ntsiab lus ntawm platelet ua kom muaj feem (thromboxane B₂, beta-thromboglobulin), ib nrab inhibition ntawm platelet adhesion thiab kev sib sau ua ke, zoo li cuam tshuam rau kev rov kho dua ntawm fibrinolytic yam ntxwv ntawm vascular endothelium, thiab nce kev ua si ntawm plasminogen, uas yog cov ua kom cov nqaij mos.

Kev siv cov hloov kho-tso glycazide, lub hom phiaj glycosylated hemoglobin (HbAlc) lub hom phiaj yog qis dua 6.5%, nrog kev paub zoo glycemic tswj raws li kev soj ntsuam mob txaus ntseeg, tuaj yeem txo kev pheej hmoo ntawm macro- thiab microvascular cov teeb meem sib xyaw nrog hom 2 mob ntshav qab zib piv nrog cov tsoos glycemic tswj.

Kev ua tiav ntawm kev tswj hwm glycemic muaj nyob rau hauv kev sau ntawv ntawm gliclazide (qhov nruab nrab ib hnub yog 103 mg) thiab nce nws cov koob tshuaj (txog li 120 mg ib hnub) thaum noj cov qauv kev kho mob ntawm tus keeb kwm yav dhau (lossis hloov) ua ntej ntxiv nws nrog lwm cov tshuaj hypoglycemic (piv txwv li, insulin, metformin thiazolidinedione derivative, alpha glucosidase inhibitor). Kev siv cov gliclazide hauv pab pawg ntawm cov neeg mob tau txais kev tswj hwm glycemic (qhov nruab nrab, HbAlc tus nqi yog 6.5% thiab lub sijhawm nruab nrab ntawm kev saib xyuas tau yog 4.8 xyoo), piv nrog cov pab pawg ntawm cov neeg mob tau txais kev tswj hwm (qhov nruab nrab HbAlc tus nqi yog 7.3%) ), tau lees tias qhov kev pheej hmoo ntawm txheeb ze ntawm kev sib koom ua ke ntawm cov kab mob micro- thiab macrovascular txo qis ntau yam (los ntawm 10%) vim qhov txo qhov tseem ceeb ntawm tus txheeb ze muaj feem yuav ua mob loj microvascular (los ntawm 14%), lub sijhawm Itijah thiab kev vam meej ntawm Microalbuminuria (9%), lub raum teeb meem (11%), pib thiab muaj mob ntawm nephropathy (21%), thiab cov kev loj hlob ntawm macroalbuminuria (30%).

Thaum sau tshuaj rau gliclazide, kev tswj hwm glycemic muaj qhov zoo tseem ceeb uas tsis tau txiav txim siab los ntawm cov txiaj ntsig ntawm kev kho nrog antihypertensive tshuaj.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, glycoside yog nqus hauv cov hnyuv los ntawm 100%. Nws cov ntsiab lus nyob hauv cov ntshav plasma nce zuj zus zuj zus thawj thawj 6 teev, thiab kev mloog zoo nyob ruaj khov li 6-12 teev. Qhov kev txiav txim lossis tus nqi ntawm kev nqus ntawm gliclazide yog ywj pheej ntawm kev noj zaub mov.

Kwv yees li 95% ntawm cov tshuaj nquag khi rau cov protein ntshav. Qhov ntim ntawm kev xa tawm yog li 30 litres. Txais tos ntawm Gliclazide MV hauv ib koob tshuaj ntawm 60 mg ib hnub ib zaug tso cai rau koj los kho cov tshuaj kho gliclazide hauv cov ntshav ntshav rau 24 teev lossis ntau dua.

Gliclazide metabolism tshwm sim feem ntau hauv lub siab. Cov tshuaj pharmacologically nquag metabolites ntawm cov tshuaj no hauv ntshav tsis txiav txim siab. Gliclazide tsuas yog tawm los ntawm lub raum hauv daim ntawv ntawm cov tshuaj nruab nrog cev, kwv yees li 1% yog pom tsis txawv txav hauv cov zis. Qhov nruab nrab ib nrab-lub neej yog 16 teev (qhov ntsuas yuav txawv ntawm 12 txog 20 teev).

Ib txoj kab sib txheeb tau sau tseg ntawm qhov lees qhov tshuaj (tsis pub tshaj 120 mg) thiab thaj chaw hauv qab qhov nkhaus pharmacokinetic "xav txog - sijhawm". Hauv cov neeg laus cov neeg mob, tsis muaj kev hloov pauv hauv lub tsev kho mob.

Kev ntsuas rau siv

Raws li cov lus qhia, Gliclazide MV yog raug kho rau kev kho mob ntawm cov mob ntshav qab zib hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) nrog kev pib tshwm sim rau mob ntshav qab zib microangiopathy.

Cov tshuaj kuj tseem siv los tiv thaiv microcirculatory mob (ib txhij nrog lwm sulfonylurea derivatives).

Cov Yuav Tsum Muaj

Yam 1 ntshav qab zib mellitus (insulin-dependant),
Kev mob hnyav rau lub siab thiab lub raum,
Ketoacidosis
Mob ntshav qab zib coma thiab precoma
Siv cov khoom tsis haum nrog imidazole derivatives (suav nrog miconazole),
Kev tsis haum xeeb rau sulfonamides thiab sulfonylureas.

Kev siv Glyclazide MV tsis raug pom zoo rau kev lactating thiab cov poj niam cev xeeb tub.

Cov lus qhia rau kev siv Gliclazide MV: txoj kev thiab qhov ntau npaum li cas

Gliclazide MV noj rau qhov ncauj ua ntej noj mov.

Qhov txiaj ntsig ntawm kev noj tshuaj yog 2 zaug hauv ib hnub.

Tus kws kho mob txiav txim siab noj ib hnub rau ib leeg zuj zus, raws li cov kev tshawb fawb soj ntsuam ntawm tus kabmob thiab glycemia, ntawm lub plab khoob thiab 2 teev tom qab noj mov.

Raws li txoj cai, thawj koob tshuaj yog 80 mg rau ib hnub, qhov nruab nrab koob yog 160-320 mg rau ib hnub.

Sab sij huam

Thaum lub sijhawm siv ntawm Gliclazide MV, nws muaj peev xwm tsim kom muaj kev cuam tshuam los ntawm qee qhov kab ke hauv lub cev:

Lub plab zom mov: tsis tshua muaj - xeev siab, tsis xav noj mov, raws plab, ntuav, mob epigastric,
Endocrine system: nrog rau kev siv ntau dhau - hypoglycemia,
Hematopoietic system: hauv qee qhov mob - thrombocytopenia, leukopenia lossis agranulocytosis, ntshav liab (feem ntau thim rov qab),
Ua xua: khaus, tawv nqaij ua pob.

Noj ntau dhau

Kev noj tshuaj ntau dhau ntawm MV Glyclazide tuaj yeem tsim txoj kev loj hlob ntawm lub qog ntshav qab zib, thiab hauv kev mob hnyav, kev mob tsis nco qab.

Cov tsos mob ntawm kev mob ntshav nruab nrab ntawm kev mob ntshav qab zib tsawg uas kho tau los ntawm kev noj haus hloov, kev xaiv koob tshuaj thiab / lossis kev noj zaub mov carbohydrate. Kev ua tib zoo soj ntsuam xyuas tus neeg mob yuav tsum tau txuas ntxiv mus kom txog thaum muaj kev phom sij rau lub neej thiab kev noj qab nyob zoo. Cov mob ntshav qab zib tsawg dua tuaj kuj tseem tuaj yeem tsim ua, nrog rau qaug dab peg, tsis nco qab, lossis lwm yam kev cuam tshuam ntawm lub hauv nruab nrab lub paj hlwb. Yog tias muaj cov tsos mob no tshwm sim, nws raug nquahu tias yuav tsum tau txais kev kho mob xwm txheej ceev thiab tau pw hauv tsev kho mob.

Yog tias tus neeg mob kuaj tau tias tus mob hypoglycemic tsis nco qab los yog xav tias muaj nws, nws yuav tsum tau muab (rau ntawm lub cev, dav hlau) 50 ml ntawm 40% piam thaj tov (dextrose). Tom qab ntawd, ib qho tshuaj 5% dextrose yog txhaj rau qhov tso ntshav, uas tso cai rau koj kom muaj cov ntsiab lus zoo ntawm cov piam thaj hauv cov ntshav (nws yog kwv yees li 1 g / l). Ntshav qab zib cov ntshav yuav tsum tau saib xyuas kom zoo thiab tus neeg mob yuav tsum tau saib xyuas tsis tu ncua tsawg kawg 2 hnub tom qab pom tseeb tias noj ntau dhau. Qhov yuav tsum tau soj ntsuam ntxiv ntawm cov haujlwm tseem ceeb ntawm tus neeg mob tau txiav txim siab txuas ntxiv los ntawm nws tus mob.

Txij li thaum gliclazide khi rau qhov ntau rau cov ntshav plasma protein, lim ntshav yog qhov tsis muaj txiaj ntsig.

Cov lus qhia tshwj xeeb

Hauv kev kho mob ntawm qhov tsis yog-insulin-mob ntshav qab zib mellitus, Gliclazide MV yuav tsum tau siv ib txhij nrog cov zaub mov tsis muaj calorie nrog cov ntsiab lus tsawg ntawm carbohydrates.

Thaum siv tshuaj kho, koj yuav tsum tau soj qab xyuas txhua hnub kev hloov pauv hauv cov piam thaj, nrog rau cov qib ntawm cov piam thaj hauv cov ntshav ntawm lub plab thiab tom qab noj mov tas.

Nrog rau kev phais mob lossis txiav ua kom mob ntshav qab zib mellitus, kev siv tshuaj insulin yuav tsum tau txiav txim siab.

Xws li qhov ua rau lub ntsej muag ntshav qab zib, yog tias tus neeg mob nco qab, qabzib (lossis kua qab zib) yuav tsum siv qhov ncauj. Yog tias tsis nco qab, cov piam thaj (tso ntshav) lossis glucagon (subcutaneously, intramuscularly lossis intravenously) yuav tsum raug tswj hwm. Txhawm rau kom tsis txhob rov txhim kho ntshav qab zib tom qab rov qab nco qab, tus neeg mob yuav tsum tau txais cov zaub mov muaj carbohydrate ntau.

Kev siv ua ke ntawm gliclazide nrog cimetidine tsis pom zoo.

Nrog rau kev siv ua ke ntawm gliclazide nrog verapamil, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam kom tsis pub dhau qib ntawm cov piam thaj hauv cov ntshav, nrog acarbose, ua tib zoo saib xyuas thiab kho cov tshuaj regimen ntawm hypoglycemic agents yog qhov tsim nyog.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Cov neeg mob noj Glyclazide MV yuav tsum paub txog cov tsos mob tshwm sim ntawm kev mob ntshav qab zib thiab ceeb toom txog qhov yuav tsum tau ceev faj thaum tsav tsheb lossis ua qee yam haujlwm uas yuav tsum muaj kev puas hlwb psychomotor, tshwj xeeb tshaj yog thaum pib kho.

Cov yam ntxwv dav dav ntawm cov tshuaj

Gliclazide MV yog ib tus neeg sawv cev hauv lub qhov ncauj uas yog lub zog txuas ntawm lub cim thib ob ntawm sulfonylurea. Kev npaj ntawm pab pawg no tau siv ntev hauv kev kho mob, yos rov qab rau xyoo 1950. Thaum Ntiaj Teb Tsov Rog II, cov tshuaj no tau siv los tawm tsam ntau yam mob, thiab tsuas yog los ntawm lub caij nyoog yog lawv cov txiaj ntsig hypoglycemic tshwm sim.

Lub teb chaws ntawm kev tsim cov tshuaj yog Russia. Glyclazide MV 30 mg hauv cov ntsiav tshuaj tsuas yog daim ntawv tsuas tshuaj uas lub tuam txhab ua tshuaj tsim. Cov ntawv sau MB sawv rau Kev Hloov Kho Tawm. Qhov no txhais tau hais tias MV ntsiav tshuaj tau nqus rau hauv lub plab rau peb teev, thiab tom qab ntawd nkag mus rau cov roj ntsha thiab txo qis cov ntshav qabzib hauv cov ntshav. Cov tshuaj no muaj cov teeb meem me me rau kev txo cov ntshav qab zib, yog li ntawd, lawv tsis tshua muaj feem ua rau lub xeev ntawm lub qog ntshav (tsuas yog 1% ntawm cov neeg mob).

Cov tshuaj Gliclazide MV thaum siv muaj cov teebmeem zoo rau tus neeg mob lub cev:

Nws provokes zus tau cov tshuaj cov tshuaj insulin los ntawm tus txiav ua ke.
Txo cov ntshav qab zib.
Nws muaj cov roj ntsha insulin secretory nyhuv ntawm cov piam thaj.
Muaj ntau cov nqaij mos ua rau lub cev tsis zoo.
Stabilizes qib ntawm glycemia ntawm ib npliag plab.
Txo cov ntshav qabzib ntau lawm.
Cuam tshuam microcirculation thiab carbohydrate metabolism.

Tsis tas li ntawd, cov tshuaj txo qhov ntxim nyiam ntawm cov ntshav txhaws hauv cov hlab ntsha.

Cov lus qhia rau kev siv tshuaj

Hauv qhov no, kev siv tus kheej tsis tuaj yeem xyaum, tsuas yog tus kws kho mob, tom qab ntsuas qhov tseem ceeb ntawm cov tshuaj thiab nws ua rau tus neeg mob lub cev, tuaj yeem sau Glyclazide MV ntsiav tshuaj.

Tom qab sab laj tus kws kho mob, koj yuav tsum yuav cov tshuaj ntawm lub hwj tshuaj, pob ntawv uas muaj 60 ntsiav tshuaj. Cov tshuaj siv rau hauv cov xwm txheej zoo li no:

Hauv kev kho cov mob ntshav qab zib tsis yog-insulin, thaum kev noj zaub mov zoo thiab kev tawm dag zog tsis tuaj yeem tiv thaiv qhov txo qis hauv cov ntshav qab zib.
Rau kev tiv thaiv ntawm qhov tshwm sim ntawm pathology - nephropathy (mob raum tsis ua haujlwm) thiab retinopathy (mob ntawm retina ntawm lub pob muag).

Cov lus qhia rau kev siv muaj txhua cov ntaub ntawv tsim nyog txog cov ntsiav tshuaj, uas koj yuav tsum ua tib zoo nyeem. Thawj zaug tshuaj rau cov neeg mob nyuam qhuav pib kho, thiab rau cov neeg muaj hnub nyoog 65 xyoos yog 30 mg rau ib hnub. Lawv tau noj thaum noj tshais. Tom qab ob lub lim tiam ntawm txoj kev kho, tus kws kho mob txiav txim siab tias yuav nce qhov ntau ntxiv. Ob yam ua rau muaj feem no - cov ntsuas cov piam thaj thiab qhov mob ntshav qab zib ntau heev. Hauv qhov dav dav, qhov koob tshuaj nws txawv ntawm 60 txog 120 mg.

Yog tias tus neeg mob tsis nco qab noj cov tshuaj, tom qab ntawd ob zaug tshuaj yuav tsum tsis txhob noj nyob rau hauv txhua kis. Yog tias muaj qhov yuav tsum tau hloov pauv qhov kev noj tshuaj ntawm Gliclazide MV nrog rau lwm cov tshuaj uas muaj suab thaj, tom qab ntawd cov kev kho mob hloov ntawm hnub tom qab. Qhov kev sib xyaw ua ke no yog ua tau nrog metformin, insulin, thiab alpha glucosidase inhibitors. Cov neeg mob uas mob mentsis mus txog lub raum tsis ua hauj lwm los tib yam tshuaj. Cov neeg mob uas yuav kis tau tus mob ntshav qab zib tsawg kawg siv cov tshuaj uas muaj qhov qis tshaj plaws.

Cov ntsiav tshuaj yuav tsum muaj kev tiv thaiv nyob rau hauv qhov chaw tsis muaj kev tiv thaiv rau cov menyuam yaus, ntawm qhov cua ntawm huab cua tsis ntau tshaj 25C. Cov tshuaj no haum rau peb lub xyoos.

Tom qab hnub tas sijhawm, nws txoj kev siv yog txwv tsis pub muaj.

Cov nqi thiab cov qauv ntawm cov tshuaj

Txij li cov tshuaj no yog tsim los ntawm cov chaw tsim tshuaj paus nyob hauv, nws tus nqi tsis siab dhau. Cov tshuaj muaj peev xwm yuav tau tom lub tsev muag tshuaj lossis xaj online ntawm khw hauv online, thaum qhia tshuaj ntawm kws kho mob. Tus nqi ntawm cov tshuaj Gliclazide MV (30 mg, 60 pieces) thaj tsam ntawm 117 txog 150 rubles. Yog li ntawd, ib tus neeg twg nrog cov nyiaj tau los nruab nrab tuaj yeem them taus nws.

Cov ntsiab lus ntawm cov tshuaj no yog cov tshuaj uas tseem muaj cov tshuaj nquag gliclazide. Cov no suav nrog Glidiab MV, mob ntshav qab zib MV, Diabefarm MV. Nws yuav tsum raug sau tseg tias Cov Ntshav Qab Zis MV (30 mg, 60 daim) nws kim heev: tus nqi nruab nrab yog 300 rubles. Thiab cov nyhuv ntawm cov tshuaj no yuav luag zoo ib yam.

Thaum tus neeg mob tau ua txhaum sib txuas rau cov tshuaj gliclazide lossis cov tshuaj muaj teeb meem, tus kws kho mob yuav tsum hloov pauv kev kho mob. Txhawm rau ua qhov no, nws tuaj yeem sau tshuaj rau ib yam tshuaj zoo sib xws, uas tseem yuav ua cov nyhuv hypoglycemic, piv txwv li:

Amaryl M lossis Glemaz nrog cov khoom xyaw nquag glimepiride,
Glurenorm nrog cov tshuaj nquag glycidone,
Maninil nrog cov khoom xyaw nquag glibenclamide.

Qhov no yog cov npe tsis tiav ntawm txhua cov tsiaj tawm, cov ncauj lus kom ntxaws ntxiv tuaj yeem nrhiav hauv Is Taws Nem lossis nug koj tus kws kho mob.

Txhua tus neeg mob xaiv cov tshuaj kho mob zoo tshaj plaws raws li ob yam - nqi thiab kho cov nyhuv.

Cov neeg mob lub tswv yim hais txog cov tshuaj

Tam sim no, cov tshuaj nyob rau hauv cov pab pawg ntawm thib ob tiam sulfonylurea derivatives, uas muaj cov tshuaj Gliclazide MV, tau siv ntau dua. Qhov no yog vim qhov tseeb tias txawm hais tias cov ntsiav tshuaj muaj ntau qhov tshwm sim, lawv tshwm sim ntau tsawg dua.

Kev tshawb fawb hauv kev tshawb fawb tau muaj pov thawj qhov tshwm sim zoo ntawm cov tshuaj ntawm microcirculation. Tsis tas li ntawd, cov tshuaj tiv thaiv kev txhim kho ntawm ntau yam teeb meem:

microvascular pathologies - retinopathy thiab nephropathy,
ntshav qab zib microangiopathy,
khoom noj khoom haus kom tsawg,
ploj ntawm vascular stasis.

Sib piv kev kuaj xyuas ntawm ntau tus neeg mob, peb tuaj yeem hais qhia qee qhov kev pom zoo rau kev siv tshuaj:

ntsiav tshuaj zoo dua rau noj tom qab noj tshais,
pluas tshais yuav tsum muaj ntau nyob rau hauv carbohydrates,
koj yuav tsis tshaib plab thoob plaws ib hnub,
muaj kev ntxhov siab ntawm lub cev, koj yuav tsum hloov cov tshuaj kom ntau dua.

Tsis tas li, kev txheeb xyuas ntawm qee tus mob ntshav qab zib tau qhia tias ua raws li kev noj zaub mov kom lub cev tsawg thiab ua kom lub cev zoo dhau los yuav ua rau lub ntsej muag ntshav qab zib. Qhov no tseem siv tau rau cov neeg uas haus cawv thaum noj tshuaj. Txoj kev pheej hmoo ntawm kev txo qis hauv cov ntshav qab zib cov ntshav kuj yog suav nrog cov neeg laus.

Tus mob ntshav qab zib tawm lawv cov lus hais tias cov tshuaj yooj yim rau kev siv piv rau cov pa gliclazide, ntau npaum ntawm uas yog ob zaug loj. Ib koob tshuaj ib hnub muab cov tshuaj qeeb thiab siv tau zoo, txo qis dua kom lub ntsej muag zoo. Txawm li cas los xij, muaj qee kis tau hais tias tom qab siv tshuaj ntev (li 5 xyoos), nws cov nyhuv ua rau tsis muaj txiaj ntsig, thiab tus kws kho mob tau sau lwm yam tshuaj los hloov Gliclazide MV lossis rau kev kho txoj kev kho mob.

Gliclazide MV yog ib qho zoo tshaj plaws hypoglycemic tus neeg sawv cev uas maj mam txo cov ntshav qab zib. Txawm hais tias nws muaj qee qhov sib txuam thiab cov kev mob tshwm sim, qhov kev pheej hmoo ntawm kev tsis zoo yog 1%. Tus neeg mob yuav tsum tsis txhob noj nws tus kheej, tsuas yog tus kws kho mob, coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob, tuaj yeem sau ib qho tshuaj uas muaj txiaj ntsig. Hauv kev kho mob ntawm hom 2 mob ntshav qab zib mellitus nrog kev pab ntawm Gliclazide MV, nws tseem yuav tsum tau ua raws li kev noj haus zoo thiab kev ua neej zoo. Yog li, saib xyuas txhua txoj cai, tus neeg mob yuav muaj peev xwm ua kom tus kab mob no nyob hauv "hnab looj tes hedgehog" thiab tiv thaiv nws los ntawm kev tswj hwm nws lub neej!

Cov lus qhia ntawm Gliclazide MV yog muab hauv video hauv kab lus no.

Glyclazide, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Glyclazide ntsiav tshuaj sau ntawv hauv qhov pib thawj zaug ntawm 80 mg, noj 2 zaug hauv ib hnub 30 feeb ua ntej noj mov. Hauv lub sijhawm yav tom ntej, cov koob tshuaj tau raug hloov kho, thiab qhov nruab nrab txhua hnub tau txais yog 160 mg, thiab qhov ntau tshaj yog 320 mg. Glyclazide MB ntsiav tshuaj yuav pom cov ntsiav tshuaj tso tawm tsis tu ncua. Lub peev xwm ntawm kev hloov thiab cov koob tshuaj hauv qhov no yog txiav txim los ntawm tus kws kho mob.

Glyclazide MB 30 mg siv 1 zaug hauv ib hnub thaum lub sijhawm noj tshais. Qhov hloov pauv koob tshuaj yog tau ua tom qab 2 lub lim tiam ntawm kev kho mob. Nws tuaj yeem yog 90 -120 mg.

Yog tias koj plam cov ntsiav tshuaj koj tsis tuaj yeem noj dua ib zaug. Thaum hloov lwm cov tshuaj txo cov ntshav qab zib nrog qhov no, lub sijhawm hloov pauv tsis tas yuav tsum muaj - lawv pib noj nws hnub tom qab. Kab tias muaj kev sib xyaw nrog lojmuas, tshuaj insulinalpha glucosidase inhibitors. Rau me rau hauj sim lub raum tsis ua hauj lwm taw nyob rau tib koob tshuaj. Hauv cov neeg mob uas muaj kev phom sij ntawm hypoglycemia, siv tsawg kawg.

Kev noj ntau dhau yog tshwm sim los ntawm cov tsos mob ntawm tus mob ntshav qab zib: mob taub hau, qaug zog, tsis muaj zog ntau, tawm hws, palpitations, nce ntshav siab, arrhythmiatsaug zog ntxhov siabtxhoj puab heev, txob taus, ncua kev tsis haum, cuam tshuam lub zeem muag thiab hais lus, tshee hnyokiv taub hau cramps, bradycardiatsis nco qab.

Nrog muaj nqees ntshav qogtsis muaj qhov tsis nco qab zoo, txo qhov tshuaj ntawm cov tshuaj lossis nce qhov ntau ntawm cov carbohydrates nrog cov zaub mov.

Nyob rau hauv kev mob ntshav khov ntau heev, yuav tsum tau mus pw hauv tsev kho mob tam sim thiab kev pab yog tsim nyog: iv 50 ml ntawm 20-30% kua qabzib, tom qab ntawd 10% dextrose lossis kua nplaum tov nrog kua. Hauv ob hnub, cov piam thaj hauv qib tau saib xyuas. Kev lim ntshav ua tsis tau zoo.

Concomitant siv nrog Cimetidineuas nce siab gliclazideuas tuaj yeem ua rau mob ntshav qis.

Thaum ua ntawv thov nrog Verapamil koj yuav tsum tswj hwm qhov qib ntawm cov piam thaj.

Cov nyhuv hypoglycemic yog hwj chim thaum siv nrog salicylatesderivatives Pyrazolone, sulfonamides, tshuaj muaj roj, Phenylbutazone, Theophylline.

Kev siv cov tsis-xaiv beta-blockers nce kev pheej hmoo ntshav qog.

Thaum ua ntawv thov Acarbosecim cov nyhuv hypoglycemic ntxiv.

Thaum siv GCS (suav nrog lwm daim ntawv thov sab nrauv), barbiturates, tshuaj kho mob, tshuaj estrogenthiab progestins, Diphenin, Rifampicinlub suab thaj-txo cov nyhuv ntawm cov tshuaj yog txo.

Nyob rau qhov kub ntawm tsis ntau tshaj 25 C.

Glidiab MV, Glyclazide-Akos, Diabinax, Lawj Xeeb MV, Lawbalong, Glucostabil.

Tam sim no, derivatives muaj ntau siv dav. tiam II sulfonylureas, rau cov uas Gliclazide nyob muaj, vim tias lawv zoo dua rau cov tshuaj ntawm lub cim yav dhau los hauv kev cuam tshuam ntawm cov nyhuv hypoglycemic, vim tias qhov kev sib txuam rau β-cell receptors yog 2-5 zaug siab dua, uas tso cai ua kom ua tiav cov nyhuv thaum sau tshuaj tsawg kawg. Qhov yeeb tshuaj ntawm no tsawg dua yuav ua rau muaj kev phiv tshuaj.

Ib lub cev ntawm cov tshuaj yog tias muaj ntau yam metabolites tau tsim thaum lub sijhawm hloov cov khoom noj hauv lub cev, thiab ib qho ntawm lawv muaj qhov cuam tshuam tseem ceeb ntawm microcirculation. Ntau cov kev tshawb fawb tau pom tias txo qis mob microvascular (retinopathythiab nephropathy) hauv kev kho mob gliclazideCov. Mob heev txo tshuaj mob ntsws, kev txhim kho kev sib txuam txhim kho, ploj leeg vau stasisCov. Tias yog vim li cas nws yog tsim rau kev nyuaj mob ntshav qab zib mellitus (tshuaj mob ntsws, nephropathyThaum pib mob raum tsis ua haujlwm, hais qhia tawm) thiab qhov no tau qhia los ntawm cov neeg mob uas, rau qhov laj thawj no, tau pauv mus rau noj cov tshuaj no.

Ntau qhov tseem ceeb hais tias cov ntsiav tshuaj yuav tsum tau noj tom qab noj tshais, uas muaj cov khoom noj txaus rau hauv lub sijhawm, kev tshaib plab thaum nruab hnub tsis tso cai. Txwv tsis pub, tawm tsam tom qab ntawm kev noj zaub mov hauv lub cev tsawg thiab tom qab ua haujlwm qoj ib ce, kev tsim kho muaj peev xwm ua tau ntshav qogCov. Nrog rau kev ntxhov siab ntawm lub cev, nws yog ib qho tsim nyog yuav tau hloov cov koob tshuaj ntawm cov tshuaj. Tom qab haus dej cawv, qee tus neeg kuj tseem muaj cov ntshav qog ntshav qab zib.

Cov neeg laus yog qhov tshwj xeeb tshaj rau cov tshuaj hypoglycemic, vim tias lawv qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia yog nce. Hauv kev sib txuas no, lawv tau zoo siv cov yeeb tshuaj luv luv (tsis zoo gliclazide).
Cov neeg mob nco ntsoov hauv lawv cov kev tshuaj xyuas qhov yooj yim ntawm kev siv cov tshuaj tso tawm hloov pauv: lawv ua qeeb qeeb thiab sib luag, yog li lawv siv ib hnub ib zaug. Tsis tas li ntawd, nws cov koob tshuaj zoo yog 2 zaug tsawg dua li kev siv ib txwm gliclazide.

Muaj cov ntaub ntawv hais tias tom qab ob peb xyoos (los ntawm 3 mus rau 5 txij thaum pib lub zuj zus), kev tawm tsam tsim kho - txo qis lossis tsis muaj kev txiav txim ntawm cov tshuaj. Hauv cov xwm txheej zoo li no, tus kws kho mob tau xaiv cov kev sib xyaw ntawm lwm cov kab mob hypoglycemic.

Koj tuaj yeem yuav cov tshuaj hauv cov khw muag tshuaj ntawm txhua lub nroog ntawm Russia: Ryazan, Tula, Saratov, Ulyanovsk.

Cov tshuaj ua haujlwm li cas?

Cov nyhuv pharmacological yog hypoglycemic. Tsub tsub kom insulin ntau ntxiv los ntawm pancreatic beta hlwb thiab txhim kho kev siv ntshav qabzib. Txhawb txoj kev ua ntawm cov leeg glycogen synthetase. Pib hauv metabolic latent mob ntshav qab zib mellitus, nyob rau hauv cov neeg mob nrog exogenously Constitutional kev rog. Gliclazide normalizes glycemic profile tom qab ob peb hnub ntawm kev kho mob.

Glyclazide ua rau lub sijhawm luv luv txij li lub sijhawm mus txog thaum pib lub cev insulin, rov qab pib thaum kawg ntawm insulin secretion, thiab txo qhov hyperglycemia los ntawm kev noj zaub mov.

Tseem Ceeb! Txhim kho cov ntshav hematological, rheological zog ntawm cov ntshav, hemostasis thiab microcirculation system.

Gliclazide tseem tuaj yeem tiv thaiv kev txhim kho ntawm microvasculitis, suav nrog qhov txhab ntawm lub retina ntawm lub qhov muag. Txhawb nqa cov platelet sib sau ua ke, txo qhov sib txawv ntawm qhov txheeb ze rau kev txheeb cais, nce heparin thiab fibrinolytic kev ua haujlwm, nce heparin ua siab ntev. Nws ua kom pom cov khoom ua antioxidant, txhim kho kev sib deev vascularization, muab cov ntshav ntws mus txuas ntxiv hauv microvessels, tshem tawm cov cim ntawm microstasis.

Hauv cov ntshav qab zib nephropathy, cov tshuaj txo cov proteinuria. Siab thiab sai sai nqus los ntawm cov hnyuv. Hauv lub siab, nws ua rau lub zog oxidation nrog kev tsim cov metabolites, ib qho muaj cov ntsiab lus ntawm microcirculation. Nws yog tawm hauv daim ntawv ntawm metabolites nrog zis thiab los ntawm kev zom zaub mov.

Cov lus qhia ntxaws ntxiv rau siv

Thawj koob tshuaj rau cov neeg mob txog hnub nyoog 65 xyoos yog 80 mg / hnub, hauv ob koob tshuaj sib cais, rau cov neeg mob hnub nyoog 65 xyoos, kev kho mob yuav tsum pib nrog 40 mg 1 r / hnub. Yog tsim nyog, ntxiv tshuaj glycemic tswj yuav tsum tau nce. Cov koob tshuaj txhua hnub tuaj yeem nce hauv BPF (kev pom zoo rau kev siv tshuaj hauv tebchaws Askiv Daim Ntawv Hauv Teb Chaws, Qhov Xwm Txheej 60).

Nws raug nquahu kom nce cov koob tshuaj nrog thaj tsam tsawg kawg 14 hnub, qhov nruab nrab txhua hnub koob yog 80-240 mg hauv ob koob, koob tshuaj yog 160 mg / hnub ntawm BNF hauv ob zaug, qhov siab tshaj plaws txhua hnub koob yog 320 mg ntawm BNF Glyclazide hauv ob koob tshuaj.

Txhawm rau hloov kho cov ntsiav tshuaj, qhov pib pom zoo yog 30 mg. Qhov koob tshuaj txhua hnub yog 30-120 mg, qhov tshuaj txhua hnub yog noj ib zaug thaum noj tshais.

Cov ntsiav tshuaj yuav tsum tau nqos tag nrho, yog tias nws tsim nyog los ntxiv dag zog rau kev tswj hwm ntawm glycemia, koob tshuaj txhua hnub tuaj yeem nce mus rau 60 mg, 90 mg lossis 120 mg ib zaug thaum noj tshais, nws raug nquahu kom nce cov koob tshuaj maj mam, nrog ncua sijhawm 1 hlis, tshwj tsis yog thaum muaj txo qis hauv qabzib hauv ntshav hauv 2 lub lim tiam ntawm kev kho mob.

Hauv cov xwm txheej zoo li no, cov tshuaj tuaj yeem raug nce ntxiv tom qab 2 lub lis piam ntawm kev kho mob, qhov nruab nrab ib hnub ib zaug yog 60 mg / hnub ib zaug.

Tseem Ceeb! Ua ntej nce txoj kev siv tshuaj kho mob txhua hnub, sab laj nrog koj tus kws kho mob.

Thaum noj tshais, rau cov neeg mob feem ntau txij thaum pib kho, qhov siab tshaj plaws pom zoo noj ib hnub twg yog 120 mg 1 ntsiav tshuaj. (Cov ntsiav tshuaj) nrog kev hloov pauv ntawm cov tshuaj 60 mg yog sib npaug rau 2 ntsiav tshuaj nrog kev hloov pauv ntawm cov tshuaj 30 mg ntawm lub rooj.

Cov ntsiav tshuaj nrog kev hloov pauv ntawm cov tshuaj 60 mg yog raug rau ntu, uas ua rau nws siv tau cov tshuaj ntawm koob tshuaj 30 mg (1/2 lub rooj.) Thiab ntawm koob ntawm 90 mg (1.5 rooj.)

Hloov chaw ntawm tus neeg mob los ntawm cov kev npaj muaj Glyclazide 80 mg rau kev npaj muaj Gliclazide 60 mg hloov kho cov ntsiav tshuaj: 1 ntsiav tshuaj uas muaj Glyclazide 80 mg sib raug rau 1/2 lub rooj. cov tshuaj yog 60 mg.

Yuav noj li cas thaum cev xeeb tub

Thaum cev xeeb tub, Glyclazide yog contraindicated, yog li nws siv nyob rau lub sijhawm no thiab lactation yog qhov tsis xav tau.

Tsis tas li thaum cev xeeb tub, ib lub xeev ntawm cov kua nplaum ua kom haum tuaj yeem tshwm sim, uas tuaj yeem ua rau ntau yam tsis txaus siab thaum siv Glyclazide thaum cev xeeb tub. Yog li, thaum cev xeeb tub, nws raug nquahu kom kuaj ntshav qabzib.

Ntawm cov ntshav qab zib, nws yog ib qho tseem ceeb heev uas yuav tsum tau saib xyuas kom tsis tu ncua ntawm cov piam thaj hauv ntshav, uas tuaj yeem pab tau los ntawm cov glucometer, uas tau piav qhia meej hauv tsab xov xwm "Cov lus piav qhia tag nrho ntawm Accu-Chek Active glucometer".

Cev xeeb tub thiab lactation

Tsis muaj kev paub dua nrog kev teem sij hawm ntawm Gliclazide MV rau cov poj niam cev xeeb tub. Cov kev tshawb fawb hauv cov tsiaj tsis tau lees tias muaj teratogenic cov yam ntxwv ntawm tus yam ntxwv ntawm cov tshuaj yeeb dej caw no. Nrog cov nyiaj them tsis txaus rau cov ntshav qab zib mellitus thaum kho, muaj qhov pheej hmoo ntawm kev txhim kho kev mob plab yug me nyuam hauv plab, uas tuaj yeem txo los ntawm kev tswj glycemic txaus. Hloov chaw ntawm gliclazide hauv cov poj niam cev xeeb tub, nws raug nquahu kom siv cov tshuaj insulin, uas tseem yog cov tshuaj uas xaiv rau cov neeg mob npaj lub cev xeeb tub, lossis cov neeg uas tau xeeb tub thaum kho nrog Gliclazide MV.

Txij li thaum tsis muaj cov ntaub ntawv hais txog kev ua kom muaj txiaj ntsig ntawm cov tshuaj muaj txiaj ntsig hauv cov kua mis, thiab hauv cov menyuam yug menyuam tshiab muaj qhov pheej hmoo ntawm kev mob neonatal hypoglycemia, noj Gliclazide MB thaum lactation yog contraindicated.

Phiv thiab haus tshaj

Los ntawm lub plab zom mov, Glyclazide tuaj yeem ua rau: tsis tshua muaj tshwm sim - tsis nco qab, ntuav, ntuav, raws plab, mob epigastric.
Los ntawm cov kab mob hemopoietic: nyob rau qee kis - thrombocytopenia, agranulocytosis lossis leukopenia, ntshav liab (feem ntau thim rov qab).
Los ntawm cov kab ke endocrine: nrog kev siv ntau dhau - hypoglycemia.
Ua xua: tawv nqaij ua pob, khaus.

Kev noj ntau dhau yog tshwm sim los ntawm cov tsos mob ntawm kev mob ntshav qab zib: mob taub hau, qaug zog, qaug zog, tawm hws, palpitations, nce ntshav siab, tsis tuaj yeem, tsaug zog, ntxhov siab, chim siab, chim siab, cuam tshuam kev tsis pom kev, tsis pom kev thiab hais lus, tshee, kiv taub hau, ua kom qaug dab peg, tsis nco qab, poob siab.

Ib qho ntawm cov kev phom sij tshaj plaws yog ua rau tsis xeev (coma).

Tseem Ceeb! Thaum siv tshuaj, koj yuav tsum saib xyuas koj tus mob.

Nrog cov ntshav qog ntshav nruab nrab uas tsis muaj qhov ua kom tsis nco qab, txo qhov tsawg ntawm cov tshuaj lossis nce tus nqi ntawm cov carbohydrates nrog cov zaub mov.

Kev ntsuas thiab tus nqi

Gliclazide analogues yog:

Vero-Glyclazide,
Glidiab
Glidiab MV,
Glisid
Gliclazide MV,
Glyclazide-Akos,
Lub Neej
Glucostabil,
Diab phem
Lawbalong
Lawj xeeb
Lwj siab MV,
Diabefarm
Diabefarm MV,
Diabinax
Diabresid
Diatics
Medoclacid
Predian
Khaws.

Koj tuaj yeem yuav cov tshuaj hauv cov khw muag tshuaj ntawm txhua lub nroog ntawm Russia.

Glyclazide MV 30 mg tuaj yeem muab rau 115-147 rubles.

Ua tsaug rau tsab xov xwm no, koj tuaj yeem kawm paub ntau ntxiv txog kev siv tshuaj kho ntshav qab zib hom II tshiab.

Kev Ntsuas Xyuas Mob Ntshav Qab Zib

Nyob rau tam sim no, derivatives ntawm sulfonylureas ntawm II tiam, uas Gliclazide nyob muaj ntau dua, siv ntau vim tias lawv zoo dua rau cov tshuaj ntawm yav dhau los hauv kev kawm txog cov tshuaj hypoglycemic, txij li qhov sib koom ua ke rau β-cell receptors yog 2-5 zaug siab dua, uas tso cai kom ua tiav cov txiaj ntsig thaum sau tshuaj tsawg kawg nkaus Cov. Qhov yeeb tshuaj ntawm no tsawg dua yuav ua rau muaj kev phiv tshuaj.

Tsim nyog kom paub! Tsis tas li ntawd, ua tsaug rau Glyclazide, qhov mob hnyav ntawm angiopathies txo qis, kev noj zaub mov ntawm lub ntsej muag txhim kho, thiab vascular stasis ploj.

Yog vim li cas nws yog qhov tsim nyog rau kev mob ntshav qab zib mellitus (angiopathy, nephropathy nrog kev mob raum tsis ua haujlwm ntev, kev mob hlwb rov qab) thiab qhov no tau qhia los ntawm cov neeg mob uas, vim li no, tau pauv mus rau txais cov tshuaj no.

Ntau qhov tseem ceeb hais tias cov ntsiav tshuaj yuav tsum tau noj tom qab noj tshais, uas muaj cov khoom noj txaus rau hauv lub sijhawm, kev tshaib plab thaum nruab hnub tsis tso cai. Txwv tsis pub, tawm tsam cov keeb kwm ntawm kev noj zaub mov kom tsis txhob mob lub cev tsawg thiab tom qab kev ua kom lub cev muaj zog ntau dhau los, txoj kev txhim kho ntawm lub qog ntshav qab zib muaj peev xwm ua tau.

Nrog rau kev ntxhov siab ntawm lub cev, nws yog ib qho tsim nyog yuav tau hloov cov koob tshuaj ntawm cov tshuaj. Tom qab haus dej cawv, qee tus neeg kuj tseem muaj cov ntshav qog ntshav qab zib.

Cov neeg laus yog qhov tshwj xeeb tshaj rau cov tshuaj hypoglycemic, vim tias lawv qhov kev pheej hmoo ntawm kev txhim kho hypoglycemia yog nce. Hauv kev sib txuas no, lawv tau zoo dua siv cov tshuaj yeeb yam luv luv (ib txwm muaj gliclazide).

Cov neeg mob nco ntsoov hauv lawv cov kev tshuaj xyuas qhov yooj yim ntawm kev siv cov tshuaj tso tawm hloov pauv: lawv ua qeeb qeeb thiab sib luag, yog li lawv siv ib hnub ib zaug.Tsis tas li ntawd, nws cov koob tshuaj zoo yog 2 zaug tsawg dua cov koob tshuaj ntawm cov pa gliclazide.

Muaj cov ntaub ntawv hais tias tom qab ob peb xyoos (los ntawm 3 mus rau 5 txij thaum pib lub zuj zus), kev tawm tsam tsim kho - txo qis lossis tsis muaj kev txiav txim ntawm cov tshuaj. Hauv cov xwm txheej zoo li no, tus kws kho mob tau xaiv cov kev sib xyaw ntawm lwm cov kab mob hypoglycemic.

Tseem Ceeb! Thaum siv Glyclazide, zoo li lwm yam tshuaj, koj yuav tsum sab laj nrog koj tus kws kho mob.

Raws li qhov txuas ntxiv rau cov ntshav qab zib ntawm hom thib ob, nrog kev noj zaub mov kom raug, nws ua haujlwm zoo kawg nkaus. Kuv xav tias zoo thiab zoo dua, Kuv nyiam tus nqi thiab qhov tsis muaj qhov tshwm sim, qhov tshwm sim tiag.

Txhua txoj cai, qab zib tsis txo. Kuv haus 30 ntau dua, qab zib tsis tau poob, tab sis nce ntxiv. Kuv pib haus 60 units. lub siab lub plawv pib, siab sawv. Muaj tej zaum tsis muaj cov crappy tshuaj tau. Thiab lwm qhov tsis muaj. Yog li koj yuav lwm cov tshuaj koj tus kheej.

Yeeb tshuaj sib cuam tshuam

Nrog rau kev siv ua ke ntawm Gliclazide MV nrog rau qee yam tshuaj, qhov teebmeem tsis zoo yuav tshwm sim:

Pyrazolone derivatives, salicylates, phenylbutazone, sulfonamides antibacterial, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): potentiation ntawm hypoglycemic effect glycazide,
Cov kev xaiv tsis zoo-beta-blockers: muaj qhov ua rau muaj ntshav qab zib ntau dua, nce tawm hws thiab ntsej muag ntawm tachycardia thiab tshee tshee ntawm tes yam ntxwv ntawm tus mob ntshav qab zib tsawg,
Gliclazide thiab acarbose: muaj cov nyhuv hypoglycemic,
Cimetidine: nce plasma gliclazide concentration (mob ntshav qab zib ntau heev yuav tshwm sim, ua rau pom kev poob siab ntawm lub hauv nruab nrab lub paj hlwb thiab lub siab tsis zoo),
Glucocorticosteroids (nrog rau cov ntawv sab nraud), diuretics, barbiturates, estrogens, progestin, ua ke cov tshuaj estrogen-progestogen, diphenin, rifampicin: txo qis hauv cov nyhuv hypoglycemic glycazide.

Cov lus piv txwv ntawm Gliclazide MV yog: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeton MV, Diabefarm MV, Diabinax, Diabetalong.

Kev txheeb xyuas ntawm Gliclazide MV

Gliclazide MV belongs rau sulfonylurea derivatives ntawm lub cim thib ob thiab yog tus cwj pwm los ntawm qhov tseem ceeb ntawm hypoglycemic kev ua, uas tau piav qhia los ntawm kev sib raug zoo dua rau β-cell receptors (2-5 lub sijhawm siab dua li ntawm cov tshuaj uas dhau los). Cov khoom no tso cai rau koj kom ua tiav cov kev kho mob nrog cov koob tshuaj tsawg kawg nkaus thiab txo qhov tsawg ntawm cov kev tsis zoo.

Raws li kev txheeb xyuas, MV Gliclazide yog siv rau kev mob hnyav ntawm ntshav qab zib mellitus (retinopathy, nephropathy nrog thawj zaug mob raum tsis ua haujlwm, mob ntsws). Qhov no yog qhia los ntawm cov neeg mob uas tau hloov pauv kom tau txais cov tshuaj no. Qhov no yog vim muaj qhov tseeb tias ib qho ntawm glycazide metabolites cuam tshuam loj heev rau microcirculation, txo qhov mob ntawm angiopathy thiab qhov kev pheej hmoo ntawm kev tsim cov mob microvascular (nephropathy thiab retinopathy). Nyob rau tib lub sijhawm, cov ntshav ntws hauv lub pob txha caj qaum kuj tseem txhim kho thiab vascular stasis ploj.

Ntau tus kws tshaj lij taw qhia tias thaum kho nrog Gliclazide MV, nws yog ib qho tsim nyog kom tsis txhob muaj kev tshaib plab thiab muab kev nyiam rau cov zaub mov muaj txiaj ntsig zoo rau kev noj haus. Txwv tsis pub, tawm tsam tom qab ntawm kev noj zaub mov hauv lub cev tsawg thiab tom qab kev ua kom lub cev ntau dhau, tus neeg mob yuav ua rau lub qog ntshav qab zib. Nrog rau kev ntxhov siab ntawm lub cev, yuav tsum tau txhaj tshuaj kom haum. Hauv qee cov neeg mob, tom qab haus dej cawv thaum kho nrog Gliclazide MV, cov tsos mob ntawm cov ntshav qab zib hauv lub cev kuj tseem tau pom.

Gliclazide MV tsis pom zoo rau kev siv rau cov neeg laus cov neeg mob uas muaj feem ntau yuav txhim kho kev mob ntshav qab zib, yog li no, qhov no, nws tsim nyog siv cov tshuaj ua yeeb yam luv luv.

Cov neeg mob nco ntsoov qhov yooj yim ntawm kev siv gliclazide nyob rau hauv daim ntawv ntawm hloov kho cov ntsiav tshuaj: lawv ua qeeb qeeb dua, thiab cov haujlwm tseem ceeb tau faib tusyees thoob plaws lub cev. Vim tias qhov no, cov tshuaj yuav tau noj 1 zaug nyob rau ib hnub, thiab nws txoj kev kho tshuaj yog 2 zaug tsawg dua qhov uas tau ua ntawm gliclazide. Tseem muaj cov ntawv tshaj tawm tias nrog kev kho mob ntev (3-5 xyoos txij li thaum pib tswj hwm), qee cov neeg mob tau txhim kho kev tiv thaiv, uas xav tau kev tswj hwm ntawm lwm cov tshuaj muaj suab thaj.

Dosage daim ntawv

30 mg thiab 60 mg hloov kho cov ntsiav tshuaj tso tawm

Muaj ib ntsiav tshuaj:

cov tshuaj heev - gliclazide 30.0 mg lossis 60.0 mg,

tus zam: silicon dioxide anhydrous colloidal, hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Cov ntsiav tshuaj yog dawb los yog yuav luag dawb hauv cov xim, puag ncig hauv cov duab nrog ib tug cylindrical nto thiab ib tug bevel (rau qhov tsuas tshuaj ntawm 30 mg).

Ntsiav tshuaj yog xim dawb los yog yuav luag xim dawb, puag ncig hauv cov duab nrog ib puag ncig cylindrical, facet thiab nqis siab tshaj (rau qhov ntau npaum ntawm 60 mg).

Cov chaw muag tshuaj

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, gliclazide yog kiag li nqus los ntawm txoj hnyuv hauv lub plab. Kev noj tsis cuam tshuam rau qib kev nqus. Qhov siab ntawm gliclazide hauv plasma nce ntau zuj zus nyob rau thawj 6 teev tom qab kev tswj hwm thiab nce mus txog toj siab uas tseem pheej ua siab ntev ntev txuas txij 6 mus txog 12 teev. Qhov sib txawv ntawm tus kheej ob leeg yog qhov tsawg. Cov kev sib raug zoo ntawm cov koob tshuaj kom txog li 120 mg thiab lub plasma concentration nkhaus ntawm cov tshuaj yog qhov tso sij hawm tso siab. Kwv yees li 95% ntawm cov tshuaj khi rau cov ntshav plasma.

Gliclazide metabolized feem ntau yog nyob hauv daim siab thiab ua rau feem ntau tso zis. Kev nqhis dej yog nqa tawm feem ntau los ntawm lub raum hauv daim ntawv ntawm cov tshuaj ua kom muaj zog, tsawg dua 1% yog pom tawm tsis hloov hauv cov zis. Tsis muaj cov metabolites hauv lub plasma ntshav.

Ib nrab-lub neej (T1 / 2) ntawm gliclazide ntsuas thaj tsam 16 teev (12 txog 20 teev).

Hauv cov neeg laus, tsis muaj kev hloov pauv ntau hauv cov qauv pharmacokinetic.

Ib koob tshuaj txhua hnub ntawm 60 mg muab qhov kev txiav txim zoo ntawm gliclazide hauv plasma rau ntau tshaj 24 teev.

Cov Tshuaj Hauv Tshuaj

Gliclazide MV yog qhov ncauj tshuaj hypoglycemic los ntawm cov pab pawg ntawm II tiam sulfonylurea derivatives, uas txawv ntawm cov tshuaj zoo sib xws los ntawm qhov muaj cov N-muaj heterocyclic ntiv nplhaib nrog kev ua kom sib luag endocyclic.

Gliclazide MB txo qib ntawm cov piam thaj hauv cov ntshav, txhawb lub zais ntshav ntawm insulin los ntawm β-hlwb ntawm islets ntawm Langerhans. Tom qab 2 xyoo ntawm kev kho mob, feem ntau cov neeg mob tseem muaj qhov nce ntawm theem ntawm cov tshuaj insulin tom qab thiab kev zais C-peptides.

Hauv hom 2 mob ntshav qab zib mellitus, cov tshuaj rov qab ua rau lub sijhawm thaum kawg ntawm cov kua dej hauv cov kua dej hauv cov lus teb rau cov piam thaj thiab ua rau qib thib ob ntawm insulin secretion. Ib qho tseem ceeb nce ntxiv ntawm insulin secretion tau pom nyob rau hauv teb rau kev tsa ua vim kev noj zaub mov thiab qabzib kev tswj hwm.

Gliclazide MV muaj qhov cuam tshuam rau microcirculation. Nws txo txoj kev pheej hmoo ntawm cov ntshav me me kom tsis muaj teeb meem, muaj kev cuam tshuam rau ob lub tswv yim uas yuav koom nrog kev txhim kho ntawm kev mob ntshav qab zib mellitus: ib feem ntawm kev ua kom tsis muaj platelet thiab kev ua kom tiav thiab ib qho kev poob qis hauv kev ua kom muaj platelet ua kom muaj lwm yam (beta-thromboglobulin, thromboxane B2), nrog rau kev rov ua haujlwm ntawm fibrinolytic vascular endothelium thiab nce kev ua si ntawm cov nqaij mos plasminogen activator.

Tsuas tshuaj thiab tswj hwm

Txog kev tswj hwm qhov ncauj. Cov tshuaj yog npaj rau kev kho mob ntawm cov neeg laus xwb.

Qhov koob tshuaj txhua hnub ntawm MV Glyclazide tuaj yeem sib txawv ntawm 30 mg txog 120 mg. Nws raug nquahu kom noj ib hnub ib zaug thaum noj tshais, nqos cov ntsiav tshuaj tag nrho yam tsis ntxo.

Yog tias koj hla kev noj cov tshuaj, koj tsis tuaj yeem nce koob tshuaj rau hnub tom qab.

Ib yam li lwm yam tshuaj rau hypoglycemic, lub koob tshuaj no hauv txhua kis yuav tsum tau xaiv ib tus zuj zus, nyob ntawm tus neeg mob tshuaj tiv thaiv metabolic.

Qhov pom zoo kom pib noj yog 30 mg rau ib hnub.

Kev tswj hwm tau zoo los ntawm cov ntshav cov piam thaj, cov tshuaj no tuaj yeem siv los ua kev kho mob.

Yog tias tsis muaj kev tswj hwm qib ntshav qabzib txaus, cov koob tshuaj yuav maj mam nce mus rau 60 mg, 90 mg lossis 120 mg rau ib hnub. Lub sijhawm nruab nrab ntawm cov niaj hnub nce ntxiv rau txoj kev noj tshuaj yuav tsum yog tsawg kawg 1 hlis, tshwj tsis yog tias cov ntshav piam thaj tsis poob tom qab ob lub lis piam ntawm kev kho. Hauv cov xwm txheej zoo li no, cov koob tshuaj tuaj yeem nce ntxiv twb tau ob lub lis piam tom qab pib kho mob.

Qhov siab tshaj plaws uas pom zoo rau txhua hnub yog 120 mg.

Hloov los ntawm lwm qhov kev siv tshuaj hypoglycemic rau MV Gliclazide

Thaum hloov txoj kev loj hlob, kev noj tshuaj thiab ib nrab-lub neej ntawm cov tshuaj ua ntej yuav tsum raug txiav txim siab. Lub sijhawm hloov kev sib hloov feem ntau tsis xav tau. Kev noj Glyclazide MV yuav tsum tau pib nrog 30 mg, tom qab los ntawm kev hloov kho nyob ntawm seb cov tshuaj tiv thaiv metabolic zoo li cas.

Thaum hloov los ntawm lwm cov tshuaj ntawm sulfonylurea pab pawg nrog lub sijhawm ntev ib nrab-lub neej, txhawm rau kom tsis txhob muaj qhov cuam tshuam ntxiv ntawm ob hom tshuaj, lub sijhawm tsis muaj tshuaj nyob rau ob peb hnub yuav raug tsim nyog. Nyob rau hauv cov xwm txheej zoo li no, kev hloov mus rau Glyclazide MV ntsiav tshuaj yuav tsum pib nrog kev pom zoo thawj zaug ntawm 30 mg, tom qab los ntawm cov tshuaj phased nce hauv koob nyob ntawm cov tshuaj tiv thaiv metabolic.

Siv ua ke nrog lwm cov tshuaj tiv thaiv kab mob

Gliclazide MB tuaj yeem siv nrog kev sib ntxiv nrog biguanides, alpha-glucosidase inhibitors lossis insulin. Hauv cov neeg mob uas cov ntshav qabzib hauv lub siab tsis txaus tswj los ntawm kev noj cov tshuaj Gliclazide MV, kev kho mob insulin ib txhij kuj yuav raug txiav txim los ntawm kev saib xyuas ntawm tus kws kho mob.

Cov Neeg Laus (tshaj 65 xyoo)

Kev pom zoo koob tshuaj ntawm cov tshuaj rau cov neeg laus yog qhov zoo ib yam rau cov neeg muaj hnub nyoog qis dua 65 xyoos.

Kev pom zoo koob tshuaj rau lub raum tsis ua haujlwm ntawm qhov mob me mus rau mob hnyav yog zoo ib yam rau cov tib neeg uas lub raum tsis ua haujlwm.

Cov neeg mob ntawm Kev Ua Phem Tshaj Plaws Hypoglycemia

Yog tias muaj cov khoom noj tsis txaus lossis tsis tsim nyog, hauv kev kho mob hnyav lossis tsis zoo ntawm cov kab mob endocrine (hypopituitarism, hypothyroidism, tsis txaus los ntawm adrenocorticotropic hormone), tom qab tshem tawm cov kev kho mob yav dhau los ntev thiab / lossis ntau dua qhov kev kho mob corticosteroid, nyob rau hauv cov hlab ntshav hnyav (mob ntshav khov ntawm cov hlab plawv, mob hnyav ntawm kev cuam tshuam ntawm carotid artery. diffuse vascular mob tsis txaus ntseeg), nws raug nquahu kom muab tshuaj los ntawm cov tshuaj uas tsawg kawg ib hnub ntawm 30 mg.

Cov tshuaj sib cuam tshuam

Cov tshuaj uas txhim kho cov nyhuv ntawm Gliclazide MV (muaj kev pheej hmoo ntawm hypoglycemia)

Miconazole (thaum muab kev tswj hwm los ntawm txheej txheem lossis siv rau lub qhov ncauj ntawm qhov ncauj ua ib hom gel): txhim kho qhov kev tiv thaiv hypoglycemic ntawm MV Gliclazide (hypoglycemia yuav loj hlob mus txog hypoglycemic coma).

Tsis pom zoo rau kev siv:

Phenylbutazone txhim kho cov nyhuv hypoglycemic ntawm sulfonylurea derivatives (hloov chaw rau lawv los ntawm kev sib txuas lus nrog plasma protein thiab / lossis qeeb qee qhov kev txiav tawm ntawm lub cev).

Nws zoo dua yog siv lwm cov tshuaj tiv thaiv kev tiv thaiv.

Cawv yuav pab txo cov ntshav qab zib kom tsawg, tiv thaiv kev tiv thaiv tsis taus, tuaj yeem pab txhawb kev txhim kho hypoglycemic coma.

Nws yog ib qho tsim nyog yuav tsum tso tseg txoj kev haus cawv thiab siv tshuaj, uas suav nrog cawv.

Kev sib txuas ua ke xav tau ceev faj:

Kev siv ib txhij ntawm cov tshuaj hauv qab no tuaj yeem ua rau lub ntsej muag hypoglycemic ntawm cov tshuaj Gliclazide MV thiab qee kis ua rau pib ntawm hypoglycemia:

lwm cov tshuaj tiv thaiv kab mob (insulins, acarbose, biguanides), beta-blockers, fluconazole, angiotensin-hloov enzyme inhibitors (captopril, enalapril), H2 receptor antagonists, irreversible monoamine oxidase inhibitors (MAO I), sulfonamides thiab tshuaj tsis-steroidal tshuaj tiv thaiv.

Glyclazide MV-ua kom qaug tshuaj

Tsis pom zoo rau kev siv:

Kev siv yooj yim nrog Danazol tsis pom zoo vim qhov kev pheej hmoo ntawm kev nce ntxiv hauv cov ntshav qabzib. Yog tias nws tsis tuaj yeem tsis lees paub txog kev siv danazol, tom qab ntawd piav qhia rau tus neeg mob txog qhov tseem ceeb ntawm kev tswj hwm qhov concentration ntawm cov piam thaj hauv cov ntshav thiab zis. Qee lub sij hawm nws yuav tsum kho qhov koob tshuaj ntawm Gliclazide MV lub sijhawm thiab tom qab kev kho mob danazol.

Kev sib txuas ua ke xav tau ceev faj:

Chlorpromazine hauv kev txhaj tshuaj ntau (ntau tshaj 100 mg rau ib hnub) nce qib ntawm cov piam thaj hauv cov ntshav, txo qis cov ntshav ntawm insulin.

Glucocorticosteroids (muaj daim ntawv thov rau hauv ib cheeb tsam thiab thaj chaw: thaj tsam hauv daim tawv nqaij, lub cev nqaij daim tawv thiab qhov quav) thiab tetracosactrin ua rau muaj ntshav qabzib nrog kev txhim kho ketoacidosis, vim tias kev txo qis hauv kev ua kom tsis haum xeeb los ntawm glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (kev siv lub cev) ua rau muaj cov piam thaj ntau ntxiv.

Ua tib zoo saib xyuas qhov tseem ceeb ntawm kev saib xyuas tus kheej ntawm cov piam thaj hauv ntshav. Yog tias tsim nyog, hloov tus neeg mob mus rau kev kho mob insulin.

Yog tias koj yuav tsum siv cov kev sib txuas ua ke saum toj saud, koj yuav tsum tau them nyiaj tshwj xeeb los tswj cov ntshav qabzib hauv cov ntshav. Nws yuav tsim nyog los ntxiv kho qhov koob tshuaj ntawm MV Glyclazide ob leeg thaum sib koom ua ke kho thiab tom qab tsum tsis siv tshuaj ntxiv.

Kev sib koom tes ntawm Gliclazide MV nrog cov tshuaj tiv thaiv anticoagulant (warfarin, thiab lwm yam) tuaj yeem ua rau cov tshuaj anticoagulant nce ntxiv ntawm cov tshuaj no. Cov tshuaj tiv thaiv Anticoagulant yuav tsum tau kho kom haum.

Daim Ntawv Tso Npe Sau Npe

JLLC "Lekpharm", Koom pheej ntawm Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / fax: +375 1774 53 801, e-mail: [email protected]

Chaw nyob ntawm lub koom haum lees txais kev thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo hauv thaj chaw ntawm cov koom pheej ntawm Kazakhstan

Tus Sawv Cev Chaw Haujlwm ntawm Lekpharm COOO hauv Republican

050065, Koom pheej ntawm Kazakhstan, Almaty, Almaly koog tsev kawm ntawv, ul. Kazybek bi, d. 68/70, kaum ntawm st. Nauryzbay batyr, tel. 8 (727) -2676670, fax 8 (727) -2721178

Lub npe, chaw nyob thiab cov ntsiab lus sib cuag (xov tooj, fev, e-mail) ntawm lub koom haum hauv koom pheej ntawm Kazakhstan kev lav phib xaub rau kev sau npe tom qab kev soj ntsuam xyuas kev nyab xeeb tshuaj

Tus Sawv Cev Chaw Haujlwm ntawm Lekpharm COOO hauv Republican

050065, Koom pheej ntawm Kazakhstan, Almaty, Almaly koog tsev kawm ntawv, ul. Kazybek bi, d. 68/70, kaum ntawm st. Nauryzbay batyr, tel. 8 (727) -2676670, fax 8 (727) -2721178,