Yuav siv cov tshuaj Augmentin SR li cas?

Cov kab mob kis tau los ntawm cov kab mob rhiab: txo qis ua pa ua pa (mob ntsws, mob ntsws, pleural empyema, mob ntsws ua paug), kis tus kab mob ENT kabmob (sinusitis, tonsillitis, otitis media), kis kab mob rau cov kab mob genitourinary thiab pelvic plab hnyuv (pyelonephritis, pyelitis, cystitis,) urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubo-ovarian abscess, endometritis, kab mob vaginitis, septic rho menyuam, postpartum sepsis, pelvioperitonitis, mos chancre, gonorrhea), mob ntawm daim tawv nqaij thiab cov nqaij mos (erysipelas, impetigo, secondary) tab sis tus kab mob dermatoses, ua paug, cellulitis, mob kab mob), osteomyelitis, postoperative kab mob, kev tiv thaiv ntawm tus kab mob nyob rau hauv kev phais.

Dosage daim ntawv

zaj duab xis-txheej hloov kho ntsiav tshuaj, lyophilisate rau kev npaj ntawm kev daws rau kev tswj hwm tshuaj, hmoov rau qhov kev npaj tawm ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj, ntsiav tshuaj, hmoov rau kev npaj ntawm kev daws rau kev tswj hwm tshuaj, cov ntsiav tshuaj dispersible

Cov Yuav Tsum Muaj

Cov tshuaj tiv thaiv tsis haum rau Augmentin CP cov khoom xyaw (suav nrog cephalosporins thiab lwm yam tshuaj tua kab mob beta-lactam), kis mob mononucleosis (suav nrog cov tsos mob zoo li pob khaus), phenylketonuria, ntu kev daj ntseg lossis lub siab ua haujlwm tsis zoo vim kev siv tshuaj amoxicillin / clavulanova keeb kwm ntawm kua qaub, CC tsawg dua 30 ml / min (rau cov ntsiav tshuaj 875 mg / 125 mg).

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Cov koob tshuaj Augmentin SR raug muab raws li amoxicillin. Qhov ntau npaum li cas cov tshuaj yog teem ib lub zuj zus nyob ntawm qhov mob hnyav ntawm qhov kawm thiab qhov chaw kis tus kab mob, qhov rhiab ntawm cov kab mob.

Cov menyuam yaus hnub nyoog qis dua 12 xyoos - nyob rau hauv daim ntawv ntawm lwm yam LF npaj muaj tib cov tshuaj: ncua kev kawm, kua qab zib lossis tee rau kev tswj hwm qhov ncauj. Koob tshuaj ib zaug tau tsim nyob ntawm lub hnub nyoog: menyuam muaj txog 3 hlis - 30 mg / kg / hnub hauv 2 koob tshuaj faib, 3 hlis thiab laus dua - rau kev sib kis mob sib khuav me - 25 mg / kg / hnub hauv 2 faib koob tshuaj lossis 20 mg / kg / hnub hauv 3 koob tshuaj, nrog cov mob hnyav - 45 mg / kg / hnub hauv 2 koob lossis 40 mg / kg / hnub hauv 3 koob.

Cov neeg laus thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua: 500 mg 2 zaug / hnub lossis 250 mg 3 zaug / hnub. Hauv kev kis mob hnyav thiab mob ua pa - 875 mg 2 zaug / hnub lossis 500 mg 3 zaug / hnub.

Qhov koob tshuaj txhua hnub ntawm amoxicillin rau cov laus thiab cov menyuam hnub nyoog 12 xyoos yog 6 g, rau cov menyuam hnub nyoog qis dua 12 xyoos - 45 mg / kg lub cev hnyav.

Qhov siab tshaj plaws niaj hnub noj ntawm clavulanic acid rau cov laus thiab cov menyuam hnub nyoog dhau 12 xyoos yog 600 mg, rau cov menyuam hnub nyoog qis dua 12 xyoos - 10 mg / kg lub cev hnyav.

Nrog rau qhov teeb meem nyuaj nqos rau cov neeg laus, siv cov kev ncua raug pom zoo.

Thaum mob raum tsis ua haujlwm, qhov koob tshuaj thiab ntau zaus ntawm kev tswj hwm yog tswj hwm (kev tswj hwm ntawm LF npaj muaj tib cov tshuaj los ntawm lwm cov tuam txhab) nyob ntawm QC: nrog QC ntau dua 30 ml / min, tsis tas yuav txhaj tshuaj, nrog QC 10-30 ml / min: sab hauv - 250- 500 mg / hnub txhua 12 teev, nrog CC tsawg dua 10 ml / min - 1 g, tom qab ntawd 500 mg / hnub iv lossis 250-500 mg / hnub noj hauv ib zaug. Rau cov menyuam yaus, qhov tshuaj yuav tsum raug txo kom sib npaug.

Cov neeg mob ntawm hemodialysis - 250 mg lossis 500 mg ntawm Augmentin CP ntawm qhov ncauj hauv ib koob, ib koob tshuaj ntxiv 1 lub sijhawm ntxiv lim ntshav thiab lwm 1 koob tshuaj thaum xaus kev lim ntshav.

Pharmacological kev txiav txim

Kev npaj ua ke ntawm amoxicillin thiab clavulanic acid, beta-lactamase inhibitor. Nws ua cov kab mob bactericidal, inhibits kev sib txuas ntawm cov kab mob hauv phab ntsa.

Nquag los tawm tsam cov kab mob aerobic gram (nrog rau cov kab mob beta-lactamase los ua cov leeg tawm): Staphylococcus aureus,

Cov kab mob aerobic gram-tsis zoo: Enterobacter spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis.

Cov kab mob hauv qab no yog raug rau Augmentin CP tsuas yog hauv vitro: Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus anthracis, Streptococcus pneumoniae, Streptococcus viridans, Enterococcus faecalis, Coryneococcocpoccus peptes.

aerobic gram-cov kab mob tsis zoo (suav nrog beta-lactamase tsim cov kab mob): Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp., Bordetella pertussis, Yersinia enterocolitica, Gardnerella vaginalis, Neisseria meningitidis, Neisseriaioriiferiferiferiferiferiferifer ), Campylobacter jejuni,

anaerobic gram-cov kab mob tsis zoo (nrog rau cov kab mob tawm los tsim cov beta-lactamases): Bacteroides spp., suav nrog Bacteroides fragilis.

Clavulanic acid nyob rau hauv Augmentin CP inhibits hom II, III, IV thiab V hom beta-lactamases, tsis muaj zog tiv thaiv hom I beta-lactamases, tsim los ntawm Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid muaj lub siab tropism rau penicillinases, vim tias nws tsim cov chaw ruaj khov nrog cov enzyme, uas tiv thaiv qhov enzymatic degradation ntawm amoxicillin nyob rau hauv kev cuam tshuam ntawm beta-lactamases.

Sab sij huam

Los ntawm cov txheej txheem hauv plab: xeev siab, ntuav, raws plab, gastritis, stomatitis, glossitis, nce kev ua haujlwm ntawm "mob siab" transaminases, nyob rau hauv cov xwm txheej tsawg - mob siab daj ntseg, mob siab, mob siab (feem ntau hauv cov neeg laus, txiv neej, nrog kev kho mob ntev), pseudomembranous thiab hemorrhagic mob plab (tuaj yeem txhim kho tom qab kev kho mob), tus mob enterocolitis, tus nplaig "plaub hau" dub, tsaus nti txha hniav laus.

Hematopoietic plab hnyuv siab raum: ib qho kev hloov rov qab los ntawm prothrombin lub sijhawm thiab los ntshav, lub sijhawm thrombocytopenia, thrombocytosis, eosinophilia, leukopenia, agranulocytosis, hemolytic anemia.

Los ntawm lub paj hlwb: kiv taub hau, mob taub hau, hyperactivity, ntxhov siab vim, hloov tus cwj pwm, nriaj.

Cov tshuaj tiv thaiv hauv zos: qee kis, phlebitis ntawm qhov chaw ntawm iv txhaj.

Kev tsis haum tshuaj rau Augmentin SR Cheebtsam: urticaria, pob txuv erythematous, tsis tshua muaj - multiforme exudative erythema, anaphylactic shock, angioedema, tsis tshua muaj mob - exfoliative dermatitis, malignant exudative erythema (Stevens-Johnson syndrome), kev tsis haum tshuaj vasculitis, mob vasculitis mob nyhav rau tus kab mob pustulosis.

Lwm yam: candidiasis, kev loj hlob ntawm superinfection, interstitial nephritis, crystalluria, hematuria.

Cov lus qhia tshwj xeeb

Nrog rau kev kho mob chav nrog Augmentin SR, nws yog ib qhov tsim nyog los soj ntsuam lub xeev ntawm txoj haujlwm ntawm cov ntshav, daim siab thiab lub raum.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj nrog pluas noj.

Nws muaj peev xwm los tsim superinfection vim kev loj hlob ntawm microflora tsis raug rau nws, uas yuav tsum muaj kev hloov pauv hauv kev siv tshuaj tua kab mob.

Tej zaum yuav muab cov txiaj ntsig tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis. Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis.

Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Hauv cov neeg mob uas muaj lub siab ntsws ua rau penicillins, hla kev tsis haum nrog tshuaj tua kab mob cephalosporin yog ua tau.

Cov kab mob ntawm kev loj hlob ntawm necrotizing colitis hauv cov menyuam tshiab thiab hauv cov poj niam cev xeeb tub nrog lub sijhawm ua ntej ntawm lub qog ua kom pom tseeb.

Kev sib txuam

Antacids, glucosamine, laxatives, aminoglycosides qeeb thiab txo qhov nqus ntawm Augmentin CP Cheebtsam, ascorbic acid ntxiv rau kev nqus.

Cov kab mob Bacteriostatic (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) muaj cov nyhuv antagonistic.

Tsub kom muaj txiaj ntsig ntawm qhov tsis ncaj ntawm anticoagulants (suppressing lub plab hnyuv microflora, txo cov synthesis ntawm vitamin K thiab prothrombin index). Nrog rau kev tswj hwm tib lub sij hawm ntawm anticoagulants, nws yog ib qho tsim nyog los soj ntsuam cov ntsuas ntawm cov ntshav coagulability.

Txo qhov ua tau zoo ntawm kev tiv thaiv qhov ncauj, tshuaj, thaum lub cev zom zaub mov uas PABA tsim, ethinyl estradiol - txoj kev pheej hmoo ntawm los ntshav "ua kom tawg".

Diuretics, allopurinol, phenylbutazone, NSAIDs thiab lwm yam tshuaj thaiv cov hlab zais pa ua rau muaj kev cia siab ntau ntawm amoxicillin nyob rau hauv kev muaj pes tsawg leeg ntawm Augmentin SR (clavulanic acid yog tawm los ntawm glomerular pom).

Allopurinol ua rau muaj kev pheej hmoo ntawm kev tsim pob khaus tawv nqaij.

Cov lus nug, lus teb, tshuaj xyuas ntawm tshuaj Augmentin SR

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Daim ntawv tso tawm

Augmentin muaj nyob rau hauv cov yeeb yaj kiab-pleev xim rau cov hmoov av, hmoov txhuam rau cov tshuaj txhaj, thiab cov teeb meem qhuav rau diluting cov tee. Cov hmoov nplej rau kev npaj ntawm Augmentin ncua kev kawm thiab kua dej kuj tau tsim. Cov tshuaj ntawm cov tshuaj nrog tib cov tshuaj nquag muaj xws li: Amoxiclav, Bactoclav, Arlet, Klamosar.

Tsuas tshuaj thiab tswj hwm

Ua raws li cov lus qhia, Augmentin raug pom zoo kom noj thaum pib noj mov, cov koob tshuaj tau muab rau noj ib qho zuj zus raws li lub hnub nyoog ntawm tus neeg mob thiab qhov mob hnyav tau kis. Nrog rau kev kho mob, nws yog ib qho ua tau los ua cov kauj ruam kho - ua ntej, kev tswj hwm cov tshuaj tiv thaiv ntawm cov tshuaj, thiab tom qab ntawd lawv hloov mus rau kev tswj hwm qhov ncauj. Lub chav kawm ntawm kev kho mob nrog Augmentin feem ntau tsis dhau 14 hnub yam tsis muaj kev kho daim duab hauv chaw kuaj mob. Rau cov neeg laus thiab menyuam yaus hnub nyoog dhau 12 xyoos, nws tau sau tseg rau mob hnyav thiab mob me me 1 ntsiav tshuaj 0.375 g 3 zaug ib hnub, rau mob hnyav 1 ntsiav tshuaj 0.625 g lossis 2 ntsiav tshuaj 0.375 g 3 zaug ib hnub. Nrog kev tswj hwm txoj hauv kev tso cai, nws raug tso cai siv cov tshuaj txhua txhua 6 teev nrog qhov siv ntau tshaj plaws txhua hnub ntawm 7,2 g.

Augmentin rau cov menyuam yaus hnub nyoog qis dua 1 xyoos feem ntau tau sau tseg rau hauv cov qauv ntawm cov tee. Cov lus qhia taw qhia tias thaum muaj hnub nyoog txog 3 hlis, kev noj ib zaug yog 0.75 ml, txij li 3 txog 12 hlis - 1.25 ml. Thaum muaj mob hnyav nrog kev tswj hwm cov tshuaj txhua 6-8 teev, ib zaug ntawm Augmentin rau cov menyuam muaj hnub nyoog 3 hlis txog 12 xyoos yog 30 mg / kg lub cev hnyav, nce txog 3 lub hlis ntawm tib lub koob tshuaj txhua 12 teev. Tsis tas li, cov menyuam yaus hnub nyoog qis dua 12 xyoos raug txwv txiav Augmentin lossis kua txiv. Raws li cov lus qhia, cov menyuam muaj 9 hlis txog 2 xyoos tau sau tseg 2.5 ml (0.156 g / 5 ml), txij li 2 txog 7 xyoo - 5 ml (0.156 g / 5 ml), txij li 7 txog 12 xyoos - 10 ml (0.156 g) / 5 ml) peb zaug hauv ib hnub, nrog mob hnyav, qhov tshuaj tso cai kom muab ob npaug.

Kev ncua Augmentin yog npaj rau kev siv tam sim ntawd ua ntej siv, cov hmoov yaj tau yaj hauv dej rhaub ntawm chav sov. Dej ntxiv rau qhov cim rau ntawm lub vial, thaum lub ntsiab lus maj mam shaken, thiab tom qab ntawd tsawm mus txog kom txog thaum yaj tag hauv 5 feeb. Ua ntej txhua qhov siv, lub vial yuav tsum tau ua kom tsis txhob muaj zog, txhawm rau txiav txim siab qhov ntau npaum li cas, ntsuas lub hau ntim taub hau, ua tib zoo ntxuav nrog dej tom qab siv txhua zaus. Lub diluted raug muab tshem tawm yog muab tso rau hauv lub tub yees rau tsis pub dhau 7 hnub, tab sis tsis khov.

Cov chaw muag tshuaj

Farmakokinetics

Ob feem ntawm Augmentin® SR (amoxicillin thiab clavulanic acid) yog ua kom tiav nyob rau hauv kev daws teeb meem ntawm lub zog pH qhov tseem ceeb. Ob lub Cheebtsam tau nrawm thiab zoo rau kev tswj hwm qhov ncauj. Augmentin Kev Pom Tsis Zoo® SR txhim kho thaum noj thaum pib noj mov.

Tshuaj

Koob tshuaj(mg)

T> MIC^ xyob h(%)

Cmax (mg/l)

Tmax (xyob h)

Auc

T1 / 2 (xyob h)

Amoxicillin

Augmentin SR 1000 / 62.5 mg x 2

Clavulanate

Augmentin SR 1000 / 62.5 mg x 2

ND - tsis txhais

T> MIC sijhawm> yam tsawg kawg nkaus inhibitory

Augmentin Qhia Txog Kev Txhawb Nqaij Tso Tawm® SRs muaj qhov tshwj xeeb kws kho mob / cov kws kho mob sib zog.

Qhov Ntsuas T> MIC tau thaum muab cov tshuaj Augmentin® SR yog qhov sib txawv ntawm qhov tau txais nrog tib lub koob tshuaj ntawm cov ntsiav tshuaj nrog kev tso tawm tam sim ntawd ntawm cov tshuaj yeeb dej caw.

Thaum muab cov tshuaj ntawm qhov ncauj, kho tshuaj ntau ntawm amoxicillin thiab clavulanic acid tau pom nyob rau hauv cov ntaub so ntswg thiab cov kua dej interstitial. Kev kho mob ntau ntawm ob qho tshuaj muaj nyob hauv lub zais zis, lub plab hauv plab, tawv nqaij, adipose thiab cov leeg nqaij, nrog rau cov kua dej synovial thiab peritoneal, bile thiab pus. Amoxicillin thiab clavulanic acid tsis muaj zog khi rau cov protein, kev tshawb fawb pom tau tias cov protein khi cov ntsiab lus yog 25% rau clavulanic acid thiab 18% rau amoxicillin ntawm lawv cov ntshav plasma tag nrho. Hauv cov kev tshawb fawb tsiaj, tsis muaj kev txuam nrog ntawm cov ntawm cov feem hauv cov khoom nruab nrog tau tsim.

Amoxicillin, zoo li lwm yam penicillins, tuaj yeem pom muaj nyob hauv niam mis. Cov kab ntawm clavulanic acid kuj tseem muaj nyob hauv niam cov kua mis. Cov kev tshawb fawb tsiaj yug me nyuam tau pom tias amoxicillin thiab clavulanic acid tuaj yeem hla qhov kev tiv thaiv placental, tab sis tsis muaj pov thawj pom txog kev tsis taus los yog muaj kev phom sij ntawm tus me nyuam hauv plab.

Amoxicillin yog qee cov tso tawm hauv cov zis hauv daim ntawv ntawm tsis muaj zog penicillinic acid nyob rau hauv ib qho nyiaj npaum li 10-25% ntawm cov koob tshuaj. Clavulanic acid yog metabolized hauv tib neeg lub cev mus rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid thiab 1-amino-4-hydroxy-butan-2-ib thiab yog tawm nrog tso zis thiab quav, ntxiv rau hauv cov qauv ntawm cov roj carbon dioxide nrog cov pa tawm kom zoo.

Amoxicillin tsuas yog tawm hauv lub raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab. Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid yog cov tsis hloov pauv hauv cov zis. Kev siv ua ke nrog probenecid inhibits qhov kev tshem tawm ntawm amoxicillin, tab sis tsis ncua sij hawm qhov kev tshem tawm clavulanate los ntawm ob lub raum.

Tsis tas yuav txhaj ib koob.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Tsis tas yuav hloov qhov tshuaj ntawm cov tshuaj nrog creatinine tshem tawm> 30 ml / min. Hauv cov neeg mob nrog creatinine tshem tawm tsawg dua 30 ml / min, noj cov tshuaj tsis pom zoo.

Cov neeg mob Hemodialysis

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Siv nrog ceev faj; cov ntaub ntawv rau cov koob tshuaj noj yuav tsis txaus.

Cov Tshuaj Hauv Tshuaj

Augmentin® SR yog cov tshuaj tua kab mob sib xyaw ua ke uas muaj amoxicillin thiab clavulanic acid, nrog rau kev pom dav ntawm cov kab mob hauv lub cev, tiv taus beta-lactamase.

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub uas dhia tawm tsam ntau yam kab mob gram-positive thiab gram-tsis zoo. Amoxicillin raug pov tseg los ntawm beta-lactamase thiab tsis cuam tshuam rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid yog beta-lactamate, zoo ib yam li hauv cov qauv hauv tshuaj lom rau penicillins, uas muaj peev xwm inactivate beta-lactamase enzymes ntawm cov kab mob me uas tawm tsam penicillins thiab cephalosporins, yog li tiv thaiv qhov ua tsis tiav ntawm amoxicillin. Hauv tshwj xeeb, nws muaj cov haujlwm siab tiv thaiv plasmid beta-lactamases, uas cov tshuaj tiv thaiv feem ntau cuam tshuam, tab sis tsis muaj txiaj ntsig tawm tsam hom 1 chromosome beta-lactamases.

Muaj cov clavulanic acid nyob rau hauv Augmentin® SR tiv thaiv amoxicillin los ntawm kev puas tsuaj ntawm beta-lactamases thiab nthuav nws lub zog ntawm kev ua haujlwm tiv thaiv kab mob nrog rau kev suav nrog cov kab mob me me uas feem ntau tiv taus lwm yam penicillins thiab cephalosporins. Clavulanic acid nyob rau hauv daim ntawv ntawm ib qho tshuaj tsis muaj qhov ua kom muaj kev tiv thaiv kab mob tseem ceeb.

Txhim kho txoj kev tawm tsam

Clavulanic acid tiv thaiv kev loj hlob ntawm kev tawm tsam los ntawm beta-lactamase enzymes. Daim ntawv ntawm cov tshuaj nrog maj mam tso tawm ntawm cov tshuaj nquag muaj peev xwm ua tau zoo ntawm cov tshuaj tiv thaiv cov kab mob me nrog kev tawm tsam los ntawm penicillin-khi protein.

Amoxicillin ua rau muaj kev sib tw nrog lwm cov tshuaj tua kab mob beta-lactam, beta-lacamase inhibitors thiab cephalosporins.

Mus Augmentin®SrCov kab mob me me hauv qab no yog cov nkag siab:

Gram-zoo aerobes: Bacillius anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia cov hnub qub, Streptococcusmob ntsws *†,

Cov kab mob Streptococcus pyogenes*†, Tus kab mob Streptococcus agalactiae*†, Viridans pab pawg streptococcus†, Streptococcus spp. (lwm hom mo-hemolytic tsiaj)*†, Dab Tsi Staphylococcus aureus (rhiab rau methicillin) *, Dab Tsi Staphylococcus saprophyticus (rhiab rau methicillin) Coagulase tsis zoo staphylococcus (methicillin rhiab)

Gram-negative aerobes: Bordetella mob hnoos qhuav,Haemophilus mob npaws *,

Haemophilus parainfluenzae,Helicobacter pylori,Moraxella catarrhalis *,

Neisseria gonorrhoeae,Pasteurella multocida,Mob hnoos qhuav Vibrio

Borreliaburgdorferi,Leptospiraictterohaemorrhagiae,Treponema pallidum

Gram-zoo anaerobes: Clostridium spp.,Peptococcus niger,Peptostreptococcus magnus,Peptostreptococcus micros,Peptostreptococcusspp.

Gram-negative anaerobes: Bacteroides fragilis,Bacteroides spp., Capnocytophaga spp., Eikenellacorrodens,Fusobacteriumnucleatum,Fusobacterium spp., Porphyromonas spp., Prevotellaspp.

Cov kab mob uas muaj qhov ua tau kom tiv taus

Corynebacterium spp., Enterococcus faecium

Gram tsis zooaerobes:Escherichia coli *, Klebsiella oxytoca, Klebsiella pneumoniae *, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Ntxaug Yaj spp.

Cov kab mob nrog lub ntuj tsis kam:

Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei,Legionella pneumophila,Morganella morganii,Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomas maltophilia,Yersinia enterolitica

Chlamydia mob ntsws, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

* Kev ua tau zoo tau pom tias hauv kev sim tshuaj.

† _ Tsis yog-beta-lactamase-ua microorganisms

Tsuas tshuaj thiab tswj hwm

Augmentin® SR yuav tsum tau siv raws li cov lus qhia hauv nroog hauv nroog txog kev siv tshuaj kho mob, nrog rau cov ntaub ntawv hauv zos txog kev muaj tshuaj txaus.

Augmentin® SR yog npaj rau lub sij hawm luv luv kho mob ntawm cov kab mob kis tau los ntawm cov kab mob me me nkag siab rau cov tshuaj.

Qhov tsis haum rau Augmentin® SR nws txawv raws cheeb tsam thiab lub sijhawm. Nws yog ib qho tsim nyog yuav tsum kawm hauv cov ntaub ntawv hauv zos txog qhov muaj kev cuam tshuam ntawm cov tshuaj, nrog rau, yog tias ua tau, coj cov khoom thiab ua nws txoj kev cuam tshuam rhiab heev.

Txhawm rau kom ua rau lub siab nqus ntawm Augmentin® SR pom zoo kom coj los noj thaum pib noj mov. Txoj kev kho yuav tsum tsis txhob txuas ntxiv rau 14 hnub yam tsis rov ntsuas nws tus mob.

Augmentin Ntsiav Tshuaj® SR muaj qhov sib faib zawj, tso cai rau lawv kom tawg ntawm ib nrab kom yooj yim nqos, tab sis tsis kom txo tau qhov koob: ob txoj siv tau ib nrab yuav tsum tau noj ib txhij.

Cov koob tshuaj pom zoo yog 2 ntsiav tshuaj ib hnub ob zaug.

Cov neeg loj thiab hluas (16 xyoos thiab tshaj saud))

2 ntsiav tshuaj ib hnub ob zaug rau 7 txog 10 hnub

Exacerbation ntawm mob ntsws ntev

2 ntsiav tshuaj ib hnub ob zaug rau 7 hnub

Mob ntsws mob hlwb

2 ntsiav tshuaj ib hnub ob zaug rau 10 hnub

Kev tiv thaiv ntawm cov teeb meem sib kis hauv zos hauv kev kho hniav cuav

2 ntsiav tshuaj ob zaug ib hnub rau 5 hnub, pib noj yuav tsum tsis pub dhau 3 teev tom qab phais mob

Daim foos no tsis yog npaj rau cov menyuam hnub nyoog qis dua 16 xyoo.

Txo Augmentin Koob Tshuaj® SR tsis tsim nyog, cov koob tshuaj muaj tib yam li cov neeg laus.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Tsis tas yuav hloov qhov tshuaj ntawm cov tshuaj nrog creatinine tshem tawm> 30 ml / min. Hauv cov neeg mob nrog creatinine tshem tawm tsawg dua 30 ml / min, noj cov tshuaj tsis pom zoo.

Cov neeg mob Hemodialysis

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Txhawm rau siv nrog ceev faj, nws yog qhov yuav tsum tau soj ntsuam hepatic muaj nuj nqi ntawm ntu sib nrug. Tsis muaj ntaub ntawv txaus los qhia tias noj tshuaj.

Noj ntau dhau

Cov tsos mob lub plab zom zawv thiab cuam tshuam nrog dej-electrolyte tshuav yog ua tau. Amoxicillin crystalluria tau piav qhia, hauv qee kis ua rau kev loj hlob ntawm lub raum tsis ua haujlwm.

Kev Kho Mob: kev kho cov tsos mob, kev kho ntawm cov dej-electrolyte tshuav nyiaj li cas. Augmentin® SR yog tshem tawm los ntawm cov ntshav ntawm hemodialysis.

Daim Ntawv Tso Npe Sau Npe

Laboratoire GlaxoSmithKline, Fab Kis

(100, txoj kev ntawm Versailles, 78163 Marly-Le-Roi, Cedex)

Lub chaw nyob ntawm cov koomhaum uas lees txais thov nyiaj los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo (cov khoom lag luam) hauv koom pheej ntawm Kazakhstan

GlaxoSmith Klein Export Ltd Tus Neeg Sawv Cev Chaw Ua Haujlwm hauv Kazakhstan 050059, Almaty, st. Furmanova, 273

Tus xov tooj: +7 727 258 28 92, +7 727 259 09 96

3D duab

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid beta-lactamases, uas feem ntau lub luag haujlwm tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv cov chromosomal beta-lactamases ntawm hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob hauv Augmentin ® kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.

Kev tso tawm qeeb ntawm amoxicillin hauv Augmentin ® SR kev npaj tso cai rau tswj kev rhiab ntawm cov hom ntawd S. txhaws txhaws ntswgnyob rau hauv uas amoxicillin tsis kam yog vim muaj penicillin-sib khi cov protein (penicillin-resistant S. txhaws txhaws ntswg, lossis PRSP).

Hauv qab no yog cov haujlwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid hauv vitro.

Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-zoo aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pneumoniae 1,2, Tus kab mob Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2, pab pawg neeg streptococcus Viridans 2, Streptococcus spp. (lwm beta hemolytic streptococci) 1,2, Dab Tsi Staphylococcus aureus (rhiab rau methicillin) 1, Dab Tsi Staphylococcus saprophyticus (rhiab rau methicillin), coagulase-negative staphylococci (rhiab rau methicillin).

Gram-negative aerobes: Tus mob Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Gram-zoo anaerobes: Clostr> suav nrog Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros.

Gram-negative anaerobes: Bactero> suav nrog Bactero> suav nrog Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim

Gram-negative aerobes: Escherichia coli 1, Klebsiella spp., suav nrog Klebsiella oxytoca, Klebsiella pneumoniae 1, Proteus spp., suav nrog Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Gram-zoo aerobes: Corynebacterium spp., Enterococcus faecium.

Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid

Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Lwm yam: Chlamydia spp., suav nrog Chlamydia mob ntsws, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Rau cov kab mob microorganisms no, qhov ua tau zoo ntawm kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid tau pom nyob hauv kev tshawb fawb.

2 Hom kab ntawm cov kab mob no tsis tsim cov tshuaj beta-lactamases. Kev nkag siab nrog amoxicillin monotherapy qhia zoo ib yam li kev nkag siab zoo rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Hla tsis kam. Amoxicillin qhia ncaj qha rau cov ntoo khaub lig-tiv thaiv nrog lwm cov tshuaj tua kab mob beta-lactam, nrog rau kev sib xyaw ntawm cov tshuaj tua kab mob beta-lactam nrog beta-lactamase inhibitors thiab cephalosporins.

Lub tshuab ua haujlwm tiv thaiv. Clavulanic acid tiv thaiv amoxicillin los ntawm kev puas tsuaj ntawm beta-lactamases. Kev maj mam tso tawm ntawm cov khoom xyaw nquag ntawm Augmentin ® SR tshuaj ua rau muaj txiaj ntsig ntawm amoxicillin tawm tsam cov kab mob me uas nws qhov kev tawm tsam vim yog kev hloov pauv ntawm penicillin-khi cov protein.

Cov Tshuaj Pharmacokinetics

Ob lub cev sib xyaw ntawm Augmentin ® SR, amoxicillin thiab clavulanic acid, yaj tau zoo nyob rau hauv cov kev daws teeb meem nrog lub cev pH, thiab tau sai thiab tag nrho los ntawm kev mob plab tom qab kev tswj hwm qhov ncauj. Kev tshem tawm ntawm cov tshuaj nquag yog qhov zoo dua hauv kev noj tshuaj thaum pib noj mov.

Hauv qab no yog cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tom qab noj 2 lub tshuaj. Augmentin ® SR los ntawm cov neeg pab dag zog noj qab nyob zoo thaum pib noj mov.

Qhov nruab nrab pharmacokinetic tsis

Clavulanic acid