Glipizide (Glipizide) > Kev khomob thiab kev tiv thaiv

Tsim kho kev tsim tawm cov insulin los ntawm kev ua haujlwm ntawm pancreatic beta cells. Nws txo qis theem ntawm glycosylated hemoglobin thiab yoo cov kua nplaum cov ntshav tsis haum rau cov neeg mob uas muaj mob hnyav thiab hnyav ntawm cov mob ntshav qab zib tsis yog-insulin-mellitus. Txo cov zaub mov tom qab cov zaub mov hyperglycemia, nce qabzib kam rau ua thiab tshem tawm cov kua dej dawb (mus rau qhov tsawg). Cov tshuaj insulinotropic teb tshwm sim tsis pub dhau 30 feeb tom qab kev tswj hwm ntawm qhov ncauj, lub sijhawm ua nrog kev txhaj ib zaug txog 24 teev. Nws tsis cuam tshuam qhov lipid profile ntawm cov ntshav ntshav.

Hauv kev sim tshuaj nas thiab nas ntawm koob tshuaj 75 zaug ntau dua li MPD, nws tsis ua rau mob carcinogenesis thiab tsis cuam tshuam rau qhov kev muaj menyuam (cov nas). Cov kev kawm ua rau cov kab mob, thiab hauv vivo , tsis tau qhia lub zog mutagenic.

Daim ntawv foos nrawm yog nqus tau sai thiab ua tiav. Noj mov tsis cuam tshuam rau qhov nqus tag nrho, tab sis ua rau nws qeeb rau 40 feeb. C_max txiav txim siab li 1-3 teev tom qab ib koob nkaus xwb. T_1/2 yog 2–4 teev. Tom qab noj daim ntawv qeeb-ua yeeb yam, nws tshwm hauv cov ntshav tom qab 2-3 teev, C_max Nws tau ncav cuag tom qab 6-12 teev. Nws khi rau cov ntshav cov ntshav protein li ntawm 98–99%. Qhov ntim ntawm kev faib tawm tom qab kev tswj hwm yog 11 L, nruab nrab T_1/2 - 2-5 teev .Txais Cl tom qab kev txhaj tshuaj ib zaug yog 3 l / teev. Biotransformed hauv lub siab (nrog rau thawj nqe lus - me ntsis). Tsawg dua 10% yog pom tsis hloov pauv hauv cov zis thiab cov quav, li 90% yog tso tawm hauv daim ntawv ntawm cov roj ntsha nrog cov zis (80%) thiab cov quav (10%).

Cov kev mob tshwm sim ntawm cov tshuaj Glipizide

Rau qhov ua yeeb yam qeeb ntawm glipizide:

Los ntawm cov leeg hlwb thiab cov haujlwm hauv lub cev: kiv taub hau, mob taub hau, pw tsaug zog, tsaug zog, ntxhov siab, kev nyuaj siab, ntxhov siab, gait cuam tshuam, kab mob khaub thuas, hypersthesia, daim ntaub thaiv nyob rau hauv pem hauv ntej ntawm lub qhov muag, mob qhov muag, pom pob txha, mob raum.

Los ntawm cov hlab plawv system thiab ntshav (hematopoiesis, hemostasis): syncope, arrhythmia, ntshav tawm ntshav siab, qhov paub ntawm kub flashes.

Los ntawm sab ntawm cov metabolism: ntshav qog.

Los ntawm cov hnyuv: anorexia, xeev siab, ntuav, ib qho kev xav ntawm qhov hnyav hauv thaj chaw epigastric, dyspepsia, cem quav, admixture ntawm cov ntshav hauv cov quav.

Ntawm feem ntawm daim tawv nqaij: xoo pob, urticaria, khaus.

Los ntawm tus txheej txheem ua pa: rhinitis, pharyngitis, dyspnea.

Los ntawm genitourinary system: mob plab, tsis muaj libido.

Lwm yam: nqhis dej, tshee hnyo, peripheral edema, tsis muaj qhov mob thoob plaws lub cev, mob caj dab, mob leeg ntshav, mob ib ce, tawm hws.

Rau daim ntawv ua nrawm nrawm nrawm ntawm glipizide:

Los ntawm cov leeg hlwb thiab cov haujlwm hauv lub cev: mob taub hau, kiv taub hau, tsaug zog.

Los ntawm cov hlab plawv system thiab ntshav (hematopoiesis, hemostasis: leukopenia, agranulocytosis, thrombocytopenia, pancytopenia, hemolytic lossis aplastic anemia.

Los ntawm sab ntawm cov metabolism: ntshav qab zib insipidus, hyponatremia, kab mob porphyrin.

Los ntawm cov hnyuv: xeev siab, ntuav, mob epigastric, cem quav, cholestatic kab mob siab (daj tawv nqaij thiab sclera, tshem tawm cov quav thiab tso zis dub, mob rau hauv txoj cai hypochondrium).

Ntawm feem ntawm daim tawv nqaij: erythema, pob tw daj maculopapular, urticaria, photosensitivity.

Lwm yam: nce nyob rau hauv kev mloog ntawm LDH, alkaline phosphatase, indil bilirubin.

Kev sib txuam

Cov ntxhia thiab glucocorticoids, amphetamines, anticonvulsants (hydantoin derivatives), asparaginase, baclofen, calcium antagonists, carbonic anhydrase inhibitors (acetazolamide), chlortalidone, tshuaj tiv thaiv qhov ncauj, epinephrine, ethacinic acid, giurimide, thymoside, thymegium. cov qog, triamteren thiab lwm yam tshuaj uas ua rau hyperglycemia. Cov tshuaj anabolic steroids thiab androgens txhim kho hypoglycemic. Indirect anticoagulants, NSAIDs, chloramphenicol, clofibrate, guanethidine, MAO inhibitors, probenecid, sulfonamides, rifampicin nce kev ua si ntawm cov feem nyob rau hauv cov ntshav (vim yog txav tawm ntawm cov ntshav protein) thiab ua kom lub zog biotransformation. Ketonazole, miconazole, sulfinpyrazone thaiv kev tsis sib luag thiab nce rau kev mob ntshav siab. Tawm tsam cov keeb kwm yav dhau los ntawm kev haus cawv, muaj kev txhim kho ntawm disulfiram-zoo li mob syndrome (mob plab, xeev siab, ntuav, mob taub hau) tau. Antithyroid thiab tshuaj myelotoxic ntau ntxiv tuaj yeem txhim kho agranulocytosis, tom kawg, ntxiv rau - thrombocytopenia.

Noj ntau dhau

Kev Kho Mob: kev tshem tawm yeeb tshuaj, ntshav qabzib thiab / lossis kev hloov pauv ntawm kev noj zaub mov nrog qhov yuav tsum tau saib xyuas glycemia, nrog cov ntshav qog ntshav qab zib tsawg (tsis nco qab, qaug dab peg) - kev mus pw hauv tsev kho mob tam sim, kev tswj hwm ntawm 50% cov ntshav qabzib nyob nrog kev sib txig sib luag (iv dej) ntawm 10% kev daws Cov piam thaj txhawm rau kom muaj ntshav qabzib cov ntshav siab siab tshaj 5.5 mmol / l, kev kuaj xyuas glycemia yog tsim nyog rau 1-2 hnub tom qab tus neeg mob tawm hauv lub cev tsis xeev. Kev lim ntshav yog qhov ua tsis zoo.

Nqi hauv cov chaw muag tshuaj

Txheeb xyuas tus nqi ntawm Glipizide xyoo 2018 thiab cov khoom lag luam pheej yig >>> Tus nqi ntawm Glipizide hauv cov khw muag tshuaj sib txawv tuaj yeem sib txawv. Qhov no yog vim siv cov khoom siv pheej yig dua thiab cov cai tswjfwm kev ua lag luam ntawm cov chaw muag tshuaj.

Nyeem cov ntaub ntawv raug cai ntawm yeeb tshuaj Glipizid, cov lus qhia rau kev siv ntawm uas suav nrog cov ntaub ntawv dav dav thiab cov txheej txheem kev kho mob. Cov ntawv sau tsuas yog muab rau kev ua ntaub ntawv xov xwm nkaus xwb thiab tsis tuaj yeem hloov pauv txoj kev kho mob cov tswv yim.

Pharmacological kev txiav txim

Tus neeg sawv cev ntawm tus mob ntshav qab zib ntau ntau, yog sulfonylurea derivative ntawm lub cim thib ob. Tsim kho kev tsim txom cov insulin los ntawm β-hlwb ntawm tus txiav, nce qhov tso tawm ntawm insulin. Tsub qhov rhiab heev ntawm peripheral cov ntaub so ntswg rau insulin. Nws muaj hypolipidemic, fibrinolytic nyhuv, inhibits platelet aggregation. Tom qab lub qhov ncauj tswj hwm, glipizide nrawm thiab ua kom tiav los ntawm cov hnyuv.
Kev cog lus rau cov ntshav plasma protein (feem ntau nrog albumin) yog 98-99%.
Cov tshuaj txiav tawm hauv daim siab. Tsawg dua 10% raug tso tawm hauv cov zis thiab cov quav tsis hloov, li 90% yog tso zis (80%) thiab nrog quav (10%) raws li cov khoom noj metabolites.

Txoj kev ntawm daim ntawv thov

Rau cov neeg laus: Teem ib leeg zuj zus raws li kev kho mob daim duab. Qhov tshuaj thawj zaug yog 2.5-5 mg 1 zaug / hnub 15-30 feeb ua ntej noj tshais. Yog tias tsim nyog, cov koob tshuaj tuaj yeem hloov mus qeeb (nrog qee lub sijhawm) nce li 2.5-5 mg / hnub. Cov koob tshuaj txhua hnub ntawm ntau dua 15 mg yuav tsum tau muab faib ua 2 koob.
Koob tshuaj ntau ntau: ib leeg - 15 mg, ib hnub - 40 mg.

- Hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) rau cov neeg mob rog dhau lossis lub cev hnyav nrog rau kev noj zaub mov tsis muaj txiaj ntsig.

Cov ntaub ntawv dav dav txog kev quav yeeb tshuaj

Glipizide yog lub npe tseem ceeb ntawm cov tshuaj uas muaj cov tshuaj nyob hauv tib lub npe, tab sis nws yog ib feem ntawm lwm cov tshuaj.

Cov kev tivthaiv yog tus cwj pwm ntawm lub suab hypoglycemic hais, uas yog ua tiav vim nws qhov ua haujlwm ntawm cov hlwb pancreatic. Qhov tshwm sim ntawm qhov no yog kev sib txuas nquag ntawm insulin.

Cov tshuaj yog sawv cev los ntawm cov hmoov dawb dawb uas tsis muaj ntxhiab tsw. Nws tsis yog yam ntxwv los ntawm kev solubility hauv dej lossis dej cawv. Qhov kev tivthaiv nquag cuam tshuam nrog cov ntshav protein, hloov mus rau hauv cov khoom noj khoom haus. Kev zam yog nqa tawm los ntawm lub raum.

Glipizide yog tsim nyob rau hauv cov ntsiav tshuaj nrog cov ntsiab lus tseem ceeb ntawm 5 thiab 10 mg. Ntu ntu yuav txawv nyob ntawm lub npe tshuaj.

Sab sij huam

- Los ntawm cov kab mob endocrine: tsis tshua muaj - kev muaj ntshav siab (tshwj xeeb tshaj yog rau cov neeg laus, cov neeg mob uas tsis muaj zog, nrog rau noj tsis xwm yeem, haus cawv, ua rau lub siab thiab lub raum tsis ua haujlwm).
- Los ntawm cov txheej txheem plab zom mov: xeev siab, zawv plab, tsis tshua muaj tshwm sim - kab mob siab.
- Los ntawm cov kab mob hemopoietic: hauv qee kis - thrombocytopenia, leukopenia, agranulocytosis.
- Ua xua: tsis tshua muaj - tawv nqaij ua pob, khaus.
- Lwm yam: mob taub hau.

Cov lus qhia rau kev siv

Cov tshuaj yog npaj rau txhawm rau mob ntshav qab zib hom 2, yog tias kev tsis siv tshuaj ntawm kev kho mob tsis tuaj yeem nqa tawm.

Cov ntsiav tshuaj tau noj ntawm qhov ncauj, tsis ntev ua ntej noj mov, nrog cov tshuaj ntxuav nrog dej. Cov koob tshuaj nyob ntawm tus kheej cov yam ntxwv ntawm tus neeg mob. Nws yog feem ntau pom zoo kom pib nrog kev pabcuam ntawm 5 mg rau ib hnub.

Nrog rau qhov tsis muaj txiaj ntsig thiab qhov ua siab ntev, kev noj tshuaj tuaj yeem raug maj mam nce mus rau 15 mg rau ib hnub. Nws raug tso cai noj tshuaj nyob rau ib zaug, koj tseem tuaj yeem faib ua haujlwm ua ntau zaug.

Hauv qee kis, cov koob tshuaj ntawm Glipizide yuav tsum raug txo kom tsawg. Yog li, kev kho mob yuav tsum tsis txhob pib yam tsis muaj kev pom zoo los ntawm cov kws tshaj lij - tsis muaj kev paub txog kev kho mob nws nyuaj heev rau kev ntsuam xyuas cov yam ntxwv ntawm cov duab hauv chaw kuaj mob.

Skipping tshuaj yog undesirable, tab sis yog tias qhov no tshwm sim, tsis txhob noj ob zaug.

Cov txheej txheem sib tsoo thiab cov phom sij uas yuav muaj

Txawm hais tias cov txiaj ntsig ntawm cov tshuaj no rau ntshav qab zib, muaj qee zaum thaum nws siv kev txwv.

Lub ntsiab contraindications ntawm Glipizide suav nrog:

intolerance rau lub composition,
mob ntshav qab zib ketoacidosis
mob ntshav qab zib coma
cev xeeb tub
ntuj pub mis
ntshav qab zib hom 1
kev pab cuam phais mob
raug mob hnyav
npaws.

Kev txiav npluav ntawm kev siv cov tshuaj yog vim muaj kev pheej hmoo ntawm qhov tsis tuaj yeem uas yuav tshwm sim.

Ntawm lawv hais txog:

mob taub hau
kiv taub hau
qaug zog,
tsaug zog
nyuaj siab lub siab
tsis meej pem,
ntxhov siab
pom mob pob txha
mob hauv qhov muag
mob raum ntshav,
ua txhaum nyob rau hauv cov hnyuv,
xeev siab
urticaria
khaus
daim tawv nqaij ua pob,
mob ntsws npog
siab nce
arrhythmia,
txo qis libido
nce tawm hws,
ntshav qog.

Ntau yam ntawm kev ua txhaum no tsis txaus ntshai, tab sis nqa teeb meem tsis xis nyob. Lwm qhov kuj tseem tuaj yeem ua rau tus neeg mob tuag yog tias tsis tau txais kev kho mob. Yog li, ua ntej siv cov tshuaj muaj glipizide, koj yuav tsum sab laj nrog koj tus kws kho mob thiab nrhiav seb yuav noj lawv li cas. Tab sis txawm hais tias qhov kev kho mob tau sau los ntawm tus kws kho mob tshwj xeeb, koj yuav tsum ua tib zoo saib xyuas koj li kev noj qab haus huv. Kev paub txog cov kev mob tshwm sim yog qhov laj thawj uas yuav tau nrhiav kev pab.

Cov tshuaj hauv nqe lus nug tsis yog tas li tso cai rau siv. Yog tias muaj cov kabmob sib kis, nws yog qhov tsim nyog los hloov nws nrog lwm tus, nrog cov sib txawv.

Ntawm cov analogues tseem ceeb ntawm Glipizide tuaj yeem hu ua:

GlibenclamideCov. Cov tshuaj yog tus cwj pwm los ntawm kev ua haujlwm hypoglycemic, uas yog ua tiav vim cov ntsiab lus ntawm glipizide hauv nws. Qhov no txhais tau tias Minidiab yog ib qho ua tiav ntawm cov tshuaj txiav txim siab hauv qhov muaj pes tsawg leeg, thiab nws cov lus qhia yog tib yam. Cov tshuaj yog ib qho kim tshaj plaws; koj yuav tsum tau them li 1,500 rubles rau kev ntim khoom.
MetforminCov. Nws cov khoom ua kom nquag plias yog cov tshuaj metformin. Nws cuam tshuam nrog cov nquag ua cov piam thaj los ntawm lub siab, thiab tseem ua rau muaj kev cuam tshuam ntau dua ntawm cov ntaub so ntswg mus rau insulin. Cov tshuaj muaj muag nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog tus nqi ntawm 90-105 rubles.
ManinilCov. Lub hauv paus ntawm cov tshuaj no yog glibenclamide. Nws tso tawm yuav yog lam nyob rau hauv daim ntawv ntsiav tshuaj. Ntxiv rau hypoglycemic, nws muaj lub plawv cardioprotective thiab antiarrhythmic cov nyhuv. Tus nqi nws txawv ntawm 95 txog 120 rubles.
Ntsia hauv qabCov. Nws cov khoom tseem ceeb yog metformin. Cov tshuaj muaj cov ntsiav tshuaj tsim, npaj rau kev tswj hwm qhov ncauj. Nws muaj qhov xam qhovkev hypoglycemic. Lawv raug muag raws li daim ntawv xaj ntawm tus kws tshaj lij ntawm tus nqi ntawm txog 120 rubles.
GlidiabCov. Qhov no yog lwm cov tshuaj sib txuas nrog cov khoom qub. Txhawb nqa cov kev sib txuas ntawm cov tshuaj insulin hauv lub cev, thiaj li txo cov ntshav piam thaj. Tus nqi yog li 100-120 rubles.

Video los ntawm cov kws tshaj lij:

Txhua yam tshuaj no tuaj yeem ua rau muaj kev mob tshwm sim, qhov txaus ntshai tshaj plaws ntawm uas yog hypoglycemia. Lawv kuj muaj contraindications. Yog li, koj yuav tsum siv lawv tsuas yog kev tso cai los ntawm tus kws kho mob thiab raws li cov lus qhia. Nws tsis raug tso cai los xaiv cov tshuaj hloov rau qhov tshuaj ntawm koj tus kheej, nws yuav muaj kev phom sij.

Daim ntawv tso tawm

Cov ntsiav tshuaj ntawm 0.005 g (5 mg) hauv ib pob ntawm 30 daim.

Cov ntaub ntawv ntawm nplooj ntawv koj tab tom saib yog tsim rau cov ntaub ntawv lub hom phiaj nkaus xwb thiab tsis txhawb nqa nws tus kheej kev noj tshuaj hauv ib txoj kev twg. Cov peev txheej yog npaj los ua kom paub cov kws kho mob nrog cov lus qhia ntxiv txog qee yam tshuaj, yog li nce lawv qib kev tshaj lij. Kev siv yeeb tshuaj Glipizide tsis muaj swb muab kev sab laj nrog tus kws tshaj lij, nrog rau nws cov lus pom zoo ntawm txoj kev siv thiab ntau npaum li cas ntawm koj cov tshuaj xaiv.

Nqi, tshuaj xyuas thiab analogues

Txij li thaum glipizide yog ib qho kev ua haujlwm, ntau yam tshuaj muaj cov tshuaj muaj peev xwm nrhiav tau ntawm cov khw muag tshuaj ntawm Lavxias. Piv txwv, Glucotrol CL thiab Glibenez Retard. Nyob ntawm daim ntawv tso tawm, tus nqi ntawm cov tshuaj Glucotrol CL thaj tsam ntawm 280 txog 360 rubles, thiab Glibenez Retard - los ntawm 80 txog 300 rubles.

Kev txheeb xyuas ntawm cov neeg mob ntshav qab zib feem ntau uas tau noj cov tshuaj no yog qhov txaus siab. Txawm li cas los xij, ntau yam tau sau tseg tias qhov kev kho mob ntawm glipizide poob qis dua lub sijhawm, yog li nws feem ntau siv nrog lwm cov tshuaj mob ntshav qab zib. Ntawm qhov zoo ntawm cov tshuaj tuaj yeem paub qhov txawv yooj yim ntawm kev siv thiab tus nqi siab ntawm cov tshuaj muaj glipizide.

Nyob rau hauv rooj plaub thaum thaum ib cov tshuaj tsis haum vim yog contraindications los yog tsis zoo, tus kws kho mob sau ib qho tshuaj analogue. Cov tshuaj no suav nrog:

Yog tias tsis pom zoo los ntawm tus kws kho mob, kev noj tshuaj rau tus kheej tsis tsim nyog. Kev npaj muaj glipizide tuaj yeem muaj kev cuam tshuam tsis zoo rau tib neeg lub cev. Nrog rau kev siv tshuaj zoo, koj tuaj yeem ua kom cov piam thaj kom zoo li qub thiab tshem tawm cov tsos mob ntshav qab zib. Tab sis kuj peb yuav tsum tsis txhob hnov qab txog kev kho kev qoj ib ce rau ntshav qab zib thiab kev noj zaub mov kom zoo.

Hauv cov yeeb yaj kiab hauv tsab xov xwm no, kws kho mob yuav tham txog tshuaj kho ntshav qab zib.