Cov lus qhia rau kev siv tshuaj Simvagexal® thiab tshuaj xyuas txog nws

Thawj hom IIa thiab hom IIb hypercholesterolemia (nrog rau kev noj zaub mov tsis ua hauj lwm hauv cov neeg mob uas muaj kev pheej hmoo ntawm kev mob ntshav siab), ua ke nrog hypercholesterolemia thiab hypertriglyceridemia, hyperlipoproteinemia, uas tsis tuaj yeem kho los ntawm kev noj zaub mov tshwj xeeb thiab kev ua haujlwm hauv lub cev.

Kev tiv thaiv ntawm myocardial infarction (ua kom qeeb ntawm qhov mob ntawm txoj hlab ntshav atherosclerosis), mob hlab ntsha tawg thiab hloov chaw ntawm cov mob hlwb.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, ib zaug, thaum yav tsaus ntuj. Nrog rau qhov mob me me lossis mob hypercholesterolemia, thawj koob tshuaj yog 5 mg, nrog rau hypercholesterolemia thaum pib txhaj tshuaj ntawm 10 mg / hnub, nrog kev kho tsis txaus, qhov koob tshuaj tuaj yeem nce ntxiv (tsis yog ntxov dua 4 lub lis piam), qhov siab tshaj plaws txhua hnub yog 80 mg.

Nrog rau cov kab mob plawv, thawj koob tshuaj yog 20 mg (ib zaug, thaum yav tsaus ntuj), yog tias tsim nyog, qhov koob tshuaj yog maj mam nce ntxiv txhua 40 lub lis piam txog 40 mg. Yog tias qhov siab LDL tsawg dua 75 mg / dl (1.94 mmol / L), tag nrho cov tshuaj cholesterol tsawg dua 140 mg / dl (3.6 mmol / L), qhov koob tshuaj yuav tsum raug txo kom tsawg.

Hauv cov neeg mob uas mob raum tsis ua haujlwm (CC tsawg dua 30 ml / min) lossis tau txais cyclosporine, fibrates, nicotinamide, thawj koob tshuaj yog 5 mg, qhov siab tshaj plaws niaj hnub noj yog 10 mg.

Pharmacological kev txiav txim

Cov lipid-txo cov tshuaj tau synthetically los ntawm cov khoom fermentation Aspergillus terreus yog qhov ua tsis muaj zog lactone; nws yauv kuaj lub cev hydrolysis hauv lub cev los tsim hydroxy acid derivative. Cov nquag metabolite suppresses HMG-CoA reductase, ib qho enzyme uas catalyzes qhov pib tshwm sim ntawm kev tsim mevalonate los ntawm HMG-CoA. Txij li thaum hloov ntawm HMG-CoA rau mevalonate yog ib theem thaum ntxov ntawm kev coj los ua ke ntawm cov roj (cholesterol), kev siv simvastatin tsis ua rau kev txuam nrog cov tshuaj sterols hauv lub cev. HMG-CoA tau yooj yim metabolized rau acetyl-CoA, uas koom tes nrog ntau cov txheej txheem tsim khoom hauv lub cev.

Nws txo qhov kev cia siab ntawm TG, LDL, VLDL thiab tag nrho cov roj (plasma) hauv ntshav (nyob rau hauv heterozygous tsev neeg thiab tsis-tsev neeg cov hypercholesterolemia, nrog hyperlipidemia sib xyaw, thaum nce hauv cov roj (cholesterol) yog qhov phom sij). Nce HDL concentration thiab txo qis piv ntawm LDL / HDL thiab cov roj (cholesterol) tag nrho / HDL.

Qhov pib ntawm kev ua yog 2 lub lis piam tom qab pib ua haujlwm, kev kho mob siab tshaj plaws yog tom qab 4-6 lub lis piam. Cov nyhuv mob txuas ntxiv nrog kev kho mob txuas ntxiv, nrog kev txiav tsis siv tshuaj, cov ntsiab lus roj yuav rov qab mus rau nws qib qub (ua ntej kev kho).

Sab sij huam

Los ntawm lub plab zom mov: dyspepsia (xeev siab, ntuav, gastralgia, mob plab, cem quav lossis mob plab zawv plab, mob plab), mob siab, daj ntseg, nce kev ua haujlwm ntawm "mob siab" transaminases thiab alkaline phosphatase, CPK, tsis tshua muaj - mob pancreatitis.

Los ntawm cov leeg hlwb thiab cov khoom hauv lub cev: asthenia, kiv taub hau, mob taub hau, insomnia, ua kom huam, plab pheem, qhov tsis haum hlwb, qhov muag plooj, tsis pom kev, tsis hnov ​​qab.

Los ntawm cov leeg ua haujlwm: myopathy, myalgia, myasthenia gravis, tsis tshua muaj mob rhabdomyolysis.

Kev ua xua thiab tiv thaiv cov tshuaj tiv thaiv: mob caj dab, mob lupus-zoo li cov tsos mob, mob caj dab mob polymyalgia, mob rheumatism, mob vasculitis, thrombocytopenia, eosinophilia, nce ESR, mob caj dab, mob pob txaws, urticaria, photosensitivity, kub taub hau, hyperemia ntawm daim tawv nqaij, yaug ntsej muag.

Kev ua kom mob Dermatological: tawv nqaij ua pob, khaus, alopecia.

Lwm yam: ua kom ntshav txhaws, palpitations, mob raum tsis ua haujlwm (vim yog rhabdomyolysis), tsawg dua potency.

Cov lus qhia tshwj xeeb

Ua ntej pib txoj kev kho mob, nws yog ib qho tsim nyog yuav tau ua qhov kev kuaj mob siab ua haujlwm (saib xyuas cov haujlwm ntawm "daim siab" hloov tsheb txhua 6 lub lis piam rau thawj 3 lub hlis, tom qab ntawd txhua 8 lub lis piam rau cov seem thawj xyoo, thiab tom qab ntawd ib hlis ib zaug). Rau cov neeg mob tau txais simvastatin hauv ib hnub 80 mg, lub siab ua haujlwm tshuaj xyuas ib zaug txhua 3 lub hlis. Thaum muaj kev cuam tshuam ntawm kev ua haujlwm "mob siab" nce ntxiv (ntau dua 3 zaug ntawm qhov tsis suav qhov siab tshaj), kev kho mob raug tso tseg.

Hauv cov neeg mob nrog myalgia, myasthenia gravis thiab / lossis nrog kev nce siab hauv CPK cov haujlwm, kev kho tshuaj tsis pub muaj.

Simvastatin (ntxiv rau lwm qhov HMG-CoA reductase inhibitors) yuav tsum tsis txhob siv nrog kev pheej hmoo ntawm rhabdomyolysis thiab mob raum (vim muaj mob hnyav, mob ntshav qis, kev phais loj, mob plig, thiab mob ntshav qab zib tsis txaus).

Kev tshem tawm cov kev kho mob lipid-txo qis thaum lub cev xeeb tub tsis cuam tshuam loj heev rau qhov tshwm sim ntawm kev kho mob mus ntev ntawm kev kho tus mob hypercholesterolemia.

Vim qhov tseeb tias HMG-CoA reductase inhibitors inhibit cholesterol synthesis, thiab cov roj cholesterol thiab lwm cov khoom ntawm nws cov synthesis ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov menyuam hauv plab, suav nrog kev sib xyaw ntawm cov tshuaj steroids thiab cell cell, simvastatin tuaj yeem muaj qhov tsis zoo ntawm tus menyuam hauv lub cev thaum kws kho mob rau cov pojniam cev xeeb tub ( Cov poj niam ntawm kev muaj me nyuam hnub nyoog yuav tsum ua tib zoo ua raws li kev ntsuas kom tsis muaj menyuam). Yog tias cev xeeb tub tshwm sim thaum kho, cov tshuaj yuav tsum tsis ua ntxiv, thiab tus poj niam tau ceeb toom tias yuav muaj kev phom sij rau cov menyuam hauv plab.

Simvastatin tsis qhia nyob rau kis uas muaj hom I, IV, thiab V hypertriglyceridemia.

Nws ua tau zoo rau ob qho tib si hauv kev kho mob monotherapy, thiab ua ke nrog kev sib txuas ntawm cov kua tsib kua qaub.

Ua ntej thiab thaum kawg ntawm kev kho, tus neeg mob yuav tsum noj tshuaj kom tsis txhob mob hypocholesterol.

Yog tias tsis nco lub tshuaj tam sim no, cov tshuaj yuav tsum ua kom sai li sai tau. Yog tias nws yog lub sijhawm rau koob tshuaj ntxiv, tsis txhob txhaj ob npaug.

Hauv cov neeg mob uas mob raum tsis zoo, kev kho mob yog ua tiav los ntawm kev tswj raum.

Cov neeg mob yuav tsum tau qhia tam sim ntawd qhia txog cov leeg tsis hnov ​​qhov mob, cia li nkees, lossis tsis muaj zog, tshwj xeeb tshaj yog tias nws nrog nws mob lossis kub taub hau.

Kev sib txuam

Txhim kho cov txiaj ntsig ntawm kev tiv thaiv tus kheej thiab ua rau muaj kev pheej hmoo los ntshav.

Tsub kom cov concentration ntawm digoxin ntau ntxiv hauv cov ntshav dej.

Cytostatics, tshuaj tua kab mob (ketoconazole, itraconazole), fibrates, txhaj tshuaj ntau ntawm nicotinic acid, immunosuppressants, erythromycin, clarithromycin, protease inhibitors nce rhabdomyolysis.

Colestyramine thiab colestipol txo qis bioavailability (kev siv cov simvastatin ua tau 4 teev tom qab noj cov tshuaj no, nrog ntxiv nyhuv).

Cov lus nug, lus teb, tshuaj xyuas ntawm tshuaj Simvageksal

Cov ntaub ntawv muab yog npaj rau kev kho mob thiab kws tshaj lij. Cov ntaub ntawv muaj tseeb tshaj plaws txog cov tshuaj muaj nyob hauv cov lus qhia uas txuas nrog lub ntim los ntawm cov kws tsim khoom lag luam. Tsis muaj cov ntaub ntawv tso tawm rau ntawm no lossis lwm nplooj ntawv ntawm peb lub xaib tuaj yeem hloov chaw rau qhov tsis txaus siab tus kheej rau tus kws tshaj lij.

Tus cwj pwm yeeb tshuaj

Kev tsim cov Simvageksal yog nqa los ntawm German kev txhawj xeeb Hexal AG. Lub hom phiaj tseem ceeb ntawm cov tshuaj no yog txo ntshav roj, triglycerides thiab lipoproteins tsawg ntom.

Cov tshuaj no zwm rau pawg tshuaj pharmacological ntawm statins. Nws tau los ntawm cov tshuaj Aspergillus terreus, uas yog cov khoom lag luam enzymatic. INN: Simvastatin. Lub sijhawm teem ntawm Simvagexal ua tus kws kho mob tshwm sim thaum tus neeg mob txheeb xyuas:

• thawj thiab ua ke hypercholesterolemia,
• hypertriglyceridemia.

Cov yam ntxwv ntawm daim ntawv tso tawm thiab tus nqi ntawm cov tshuaj

Cov tshuaj no muaj nyob hauv daim foos. Cov no yog cov ntsiav tshuaj ellipsoidal hauv lub plhaub ntawm lub ntsej muag daj lossis xim txiv kab ntxwv (nyob ntawm seb tsuas tshuaj npaum li cas), nrog rau kev qhia tshwj xeeb thiab txaug. Cov tom kawg muaj thawj peb tus tsiaj ntawv ntsig txog lub npe ntawm cov tshuaj (SIM) thiab tus lej qhia txog qib kev xav ntawm cov tshuaj nquag ntawm cov tshuaj.

Cov ntaub ntawv hais txog tus nqi nruab nrab ntawm Simvagexal rau cov tshuaj no hauv Lavxias tau muab rau hauv lub rooj.

Simvagexal belongs rau monocomponent npaj thiab muaj nyob rau hauv nws cov muaj pes tsawg leeg ib yam khoom muaj sia - simvastatin. Lub plhaub npog ntawm cov ntsiav tshuaj muaj cov tshuaj uas muaj cov pabcuam pabcuam. Nws muaj cov hmoov txhuv nplej siab, cellulose, butylhydroxyanisole E320, magnesium stearate, ascorbic acid thiab citric acid, 5 cps thiab 15 cps hypromellose, titanium dioxide, daj thiab liab hlau oxide.

Cov ntaub ntawv hais txog pharmacodynamics thiab pharmacokinetics

Simvagexal yog ib tus neeg sawv cev lipid-txo qis. Kev noj tshuaj ntawm simvastatin yog ua nrog los ntawm hydrolysis, uas ua rau muaj qhov tsim muaj hydroxy acid derivative.

Cov tshuaj ua rau txo qis triglycerides, qis kawg thiab tsis muaj lipoproteins tsawg (LDL), thiab tag nrho cov roj (OX). Tsis tas li ntawd, nws ua rau muaj kev nce siab hauv qhov siab ntawm lipoprotein (HDL) thiab txo qhov piv ntawm OH / HDL rau LDL / HDL.

Koj tuaj yeem cia siab cov txiaj ntsig ntawm kev noj cov tshuaj no tom qab kaum rau kaum plaub hnub txij li thaum pib kho nrog Simvagexal. Kev kho mob siab tshaj plaws tau tiav tom qab ib hlis lossis ib nrab thiab ib qho kev pheej hmoo ntawm cov ntsiav tshuaj.

Daim ntawv teev cov cim thiab contraindications

Cov lus qhia rau cov tshuaj pom tias nws qhia rau kev siv ob rooj plaub:

1. Yog tias xav tau kev txhim kho cov roj cholesterol thiab lipid metabolism khoom.
2. Yog tias muaj kev pheej hmoo ntawm cov teeb meem cuam tshuam rau cov hlab plawv hlab plawv, mob plawv, mob ntshav qab zib, mob hlab ntsha tawg thiab qee qhov kev cuam tshuam txog kab mob cerebrovascular.

Cov tshuaj no yog ib qho kev hloov kho uas tau tsim los ntawm cov neeg mob uas raug mob los ntawm hypercholesterolemia (keeb kwm los yog nrhiav keeb kwm), nrog rau ntau yam kab mob plawv. Qhov no yog qhov tsim nyog nyob rau hauv qhov chaw uas yuav tau hloov kho kev noj zaub mov tsis muaj lub txiaj ntsig zoo.

Tom qab noj Simvagexal los ntawm cov neeg mob uas tau pom tias muaj teeb meem hauv kev ua haujlwm ntawm cov hlab plawv, cov hauv qab no tau pom:

• txo cov neeg tuag vim yog mob plawv,
• tiv thaiv kom tsis txhob mob plawv, mob nkees,
• txo txoj kev pheej hmoo ntawm kev mob ntshav txhaws ntawm cov hlab ntshav,
• tiv thaiv kom tau qhov kev xav tau ntawm kev phais mob uas tau ua los rov qab txhim kho peripheral revascularization,
• txo qis kev pheej hmoo ntawm tsev kho mob vim tias mob angina pectoris.

Ntawm cov contraindications los kho nrog Simvagexal, muaj:

qhov teeb meem cuam tshuam nrog kev ua haujlwm ntawm cov ntshav liab txaus (porphyria),

Tseem Ceeb! Cov tshuaj no tsis pom zoo rau siv los ntawm cov poj niam thaum cev xeeb tub, vim tias muaj pov thawj ntawm nws cov txiaj ntsig tsis zoo ntawm tus me nyuam hauv plab, uas ua rau muaj kev txhim kho ntawm kev tsis tuaj yeem hauv tus menyuam.

Cov poj niam ntawm kev yug menyuam hnub nyoog npaj rau kev xeeb tub yuav tsum zam kev kho mob nrog simvastine. Yog tias cev xeeb tub tshwm sim thaum noj Simvagexal, koj yuav tsum tsis siv nws.

Tsis muaj cov ntaub ntawv qhia txog yuav ua li cas cov tshuaj tseem ceeb ntawm cov tshuaj no cuam tshuam rau niam mis. Thaum lub sijhawm lactation, noj Simavhexal tsis pom zoo.

Kev teem caij rau cov tshuaj no rau cov menyuam yaus thiab cov hluas hauv qab lub hnub nyoog kaum yim tau ua tiav nrog kev ceev faj vim tias tsis muaj cov ntaub ntawv qhia txog kev nyab xeeb thiab ua haujlwm ntawm Simvagexal txheeb ze rau cov pab pawg hnub nyoog no.

Muaj cov mob uas siv tshuaj kho nrog qhov ceeb toom ntawm kev noj tshuaj tsawg dua thiab nrog kev kuaj ntshav ib zaug. Cov no suav nrog:

• mob raum tsis ua haujlwm
• endocrine mob
• qhov ntxim nyiam muaj ntshav qab zib
• leeg ntshav siab
• haus cawv
• hnub nyoog ntsig txog cov neeg mob tom qab 65 xyoo,
• concomitant txoj kev kho nrog cov vitamin B3, fusidic acid, Amiodarone, Verapamil, Amlodipine, Dronedaron, Ranolazine.

Cov yam ntxwv ntawm cov tshuaj

Simvagexal, raws li cov lus qhia rau kev siv txuas rau nws, yog coj ib hnub ib zaug. Qhov no yuav tsum tau ua rau thaum yav tsaus ntuj. Cov tshuaj yog ntxuav ntau nrog dej. Lub sijhawm tiv thaiv kev kho kom haum yog kho los ntawm kws kho mob. Nws tsis pom zoo kom hloov nws tus kheej rau koob tshuaj thiab lub zog ntawm cov tshuaj.

Yog tias cov tshuaj tsis dhau, tom qab ntawd cov tshuaj tuaj yeem ua kom qaug dej tau thaum lwm lub sijhawm, ua kom cov koob tshuaj tsis hloov. Qhov tseem ceeb muab tshuaj yog tsim raws li theem ntawm cov roj (cholesterol) uas tau pom nyob hauv plaub lis piam sib nrug.

Tus qauv muab tshuaj yog 40 milligrams ntawm simvagexal. Nws tuaj yeem nce ntxiv txog 80 milligrams ib hnub yog tias muaj mob plawv plawv thiab kho mob tsis zoo txaus.

Cov neeg mob uas tau mob los ntawm kev mob plawv coronary tau sau rau ib koob tshuaj 20 milligrams. Tom qab ib hlis, yog tias tsim nyog, cov tshuaj ntxiv tau nce mus rau 40 milligrams. Nrog rau qhov txo qis hauv cov roj (cholesterol) tag nrho rau 3.8 mmol / litre lossis tsawg dua, cov ntsiav tshuaj noj tau tsawg.

Coronary mob plawv

Yog tias tus neeg mob tau txais kev kho mob ntxiv nrog Cyclosporine, Nicotinamide lossis fibrates, ces cov tshuaj tiv thaiv thawj thiab ntau tshaj txhua hnub txo mus rau 5-10 milligrams. Cov kev coj ua no tib yam nkaus yog tias kev kuaj mob raum tsis ua haujlwm.

Muaj cov tshuaj tsis haum thiab noj tshaj

Hauv cov npe ntawm cov kev mob tshwm sim los ntawm Simvagexal kev kho mob, koj tuaj yeem pom cov hauv qab no:

1. Los ntawm cov tsis nkag siab thiab cov hlab ntsha: qhov tshwm sim ntawm kev huam mob hauv cov leeg nqaij, asthenic syndrome, kiv taub hau, pom kev plooj plooj, caj dab, saj tsis meej, mob rau hauv lub taub hau, pw ntxhov, pw tsis tsaug zog.
2. Los ntawm sab hauv lub plab zom mov: cem quav, xeev siab, dyspepsia, ntuav, mob plab, nce siab hloov mus rau daim siab, creatine phosphokinase (CPK), muaj roj ntau dua, muaj kab mob, ua rau lub plab, mob hnyuv, mob siab.

Cov tsos mob tshwj xeeb tsis tau tsim tsa los mus dhau qhov ntau ntawm cov tshuaj (qhov siab tshaj plaws tau tso cai yog 450 milligrams).

Sau cov analogues

Ntawm cov analogues ntawm Simvagexal, uas muaj cov tshuaj nquag simvastine, hauv qab no tuaj yeem sib txawv:

Hungarian tshuaj Simvastol.Muaj nyob hauv daim ntawv foos ntawm kev noj tshuaj 10 thiab 20 milligrams. Cov pob muaj 14 thiab 28 ntsiav tshuaj. Cov cuab yeej no muaj cov txiaj ntsig zoo ib yam rau Simvagexal, cov npe ntawm kev cim thiab contraindications. Ua ntej noj cov tshuaj, tus neeg mob tau noj tshuaj rau hypocholesterol.

Cov tshuaj tau coj ib hnub ib zaug thaum yav tsaus ntuj. Qhov kev siv tshuaj txhua hnub pom zoo los ntawm cov kws kho mob sib txawv ntawm 10 txog 80 milligrams, nyob ntawm kev kuaj mob thiab muaj cov kab mob concomitant. Rau feem coob ntawm cov neeg mob, cov koob tshuaj zoo tshaj plaws uas muab cov nyhuv xav ua kom haum yog 20 milligrams. Tus nqi ntawm cov tshuaj ntawm 169 txog 300 rubles.

Ntawm lwm cov tshuaj analogue pom zoo: Vazilip (Slovenia), Zokor (Netherlands), Simvalimit (Latvia), Simgal (Ixayees), Zorstat (Croatia), Avenkor (Russia), Simvastatin (Russia), Sinkard (Is Nrias teb).

Simvagexal tshuaj: kev taw qhia rau kev siv, analogues, tshuaj xyuas

Hauv cov ntshav qab zib mellitus, nws yog ib qho tseem ceeb tsis tsuas yog ntsuas ntsuas ntshav qab zib, tab sis tseem yuav tsum tau ntsuas cov kab mob ntshav qab zib tsis tu ncua. Yog tias qhov ntsuas no dhau qhov ntsuas, tus kws kho mob tau sau ntawv rau kev noj zaub mov tshwj xeeb thiab kho tshuaj.

Cov tshuaj uas nrov tshaj plaws rau hypercholesterolemia yog Simvagexal, nws hais txog cov tshuaj lipid-txo qis nrog cov tshuaj simvastatin.

Cov ntsiav tshuaj haum rau kev kho mob ntawm cov neeg mob hnub nyoog 18 xyoo. Koj tuaj yeem yuav yuav tau hauv txhua lub tsev muag tshuaj thaum muab tshuaj los noj. Cov koob tshuaj tau txiav txim los ntawm tus kws kho mob ib leeg zuj zus, tsom mus rau keeb kwm kho mob, muaj cov contraindications thiab kab mob me.

Cov tshuaj ua haujlwm li cas?

Qhov kev npaj tau ua synthetically los ntawm cov khoom siv enzymatic Aspergillus terreus qis cov plasma cov ntsiab lus ntawm triglycerides, qis lipoproteins ntau qhov qis thiab tsawg, thiab tseem nce cov ntsiab lus ntawm high lipoproteins.

Thawj qhov tshwm sim zoo tuaj yeem pom 14 hnub tom qab pib kho. Qhov siab tshaj plaws kho tau ua tiav maj, tom qab ib hlis thiab ib nrab.

Nws yog ib qho tseem ceeb uas yuav tsum tau ua kom tiav cov kev kho kom haum thiaj li yuav tuav tau qhov kev coj zoo mus ntev.

Tus kws kho mob sau ntawv muab tshuaj rau yog tias tus neeg mob muaj:

• Hypercholesterolemia,
• Hypertriglyceridemia,
• Ua ke hypercholesterolemia.

Cov tshuaj siv yog siv yog tias cov khoom noj tshwj xeeb tsis pab. Tsis tas li, kev siv cov ntsiav tshuaj tso cai rau kev tiv thaiv yog tias muaj kev pheej hmoo ntawm myocardial infarction nrog cov roj (index) ntawm ntau dua 5.5 mmol / litre.

Ntxiv nrog rau cov tshuaj nquag simvastatin, oval-puab cov ntsiav tshuaj dawb, daj lossis liab xim muaj ascorbic acid, hlau oxide, lactose monohydrate, pob kws hmoov txhuv nplej siab, magnesium stearate, hypromellose, titanium dioxide.

Cov lus qhia rau kev siv tshuaj

Raws li phau ntawv txuas nrog, koj yuav tsum noj Simvagexal nyob rau yav tsaus ntuj ib hnub ib zaug, haus dej kom ntau. Kev ncua sijhawm ntawm kev kho yog txiav txim los ntawm tus kws kho mob mus kawm, kev hloov ntawm tus kheej qhov ntau thiab cov tshuaj yog tsis tso cai.

Yog tias tam sim no ploj lawm, cov tshuaj no yuav siv lwm lub sijhawm, thaum muab tshuaj rau qhov qub. Tom qab tshuaj xyuas tus neeg mob, kawm txog keeb kwm kev kho mob thiab kev sim siab, tus kws kho mob txiav txim siab ntau npaum li cas cov ntsiav tshuaj xav tau thaum pib kho.

Qhov tseem ceeb koob tshuaj yog tsim, tsom rau plasma theem ntawm cov cholesterol, uas tau txais hauv lub sijhawm luv ntawm plaub lub lis piam.

1. Hauv kev muab tshuaj rau, tus neeg mob yuav siv 40 mg ib hnub twg. Qhov ntim no tuaj yeem nce ntxiv txog 80 mg rau ib hnub nyob ntawm qhov muaj mob plawv plawv thaum kev kho mob tsis muaj txiaj ntsig.
2. Cov neeg mob uas muaj mob plawv coronary noj 20 mg ib hnub twg. Tom qab ib hlis, qhov koob tshuaj yog tias tsim nyog nce ntxiv txog 40 mg. Xws li yuav txo qis hauv cov roj (cholesterol) tag nrho rau 3.6 mmol / litre thiab qis dua, cov ntsiav tshuaj tsawg dua.
3. Yog tias ib tus neeg tau txais kev kho mob ntxiv nrog Cyclosporine, Nicotinamide lossis fibrates, qhov pib thiab qhov siab tshaj plaws niaj hnub tau txo yog txo rau 5-10 mg. Yuav tau ua zoo ib yam li yog muaj lub raum tsis ua hauj lwm.

Leej twg yog contraindicated nrog kev siv tshuaj kho

Nws yog ib qho tseem ceeb uas yuav tsum xav txog tias cov ntsiav tshuaj muaj ntau yam tshuaj tiv thaiv, yog li ntawd kev siv tshuaj nws tus kheej yuav tsum tsis txhob ua. Ua ntej noj Simvagexal, koj yuav tsum nyeem cov lus qhia rau kev siv.

Tus nqi ntawm ib cov tshuaj nrog kev tshuaj xyuas zoo yog 140-600 rubles, nyob ntawm lub ntim. Hauv tsev muag tshuaj koj tuaj yeem nrhiav pob 5, 10, 20, 30, 40 mg. Txhawm rau kom yoog tau ib hom qauv kev kho, nws pom zoo kom yuav Hexal Simvagexal ntsiav tshuaj 20mg hauv qhov nyiaj ntawm 30 pcs.

Cov tshuaj yog contraindicated yog tias tus neeg mob muaj:

• daim siab ua hauj lwm
• muaj lub cev tsis haum rau lub tshuaj,
• rhiab heev rau statins,
• mob hlwb
• ua txhaum ntawm kev tsim cov qe ntshav liab (porphyria).

Koj tsis tuaj yeem nqa tawm txoj kev kho mob yog tias ib tus neeg tau noj Itraconazole, Ketoconazole, tshuaj rau kev kho mob HIV sib kis. Tsis tas li, cov ntsiav tshuaj yog contraindicated rau cov poj niam cev xeeb tub thiab lactating.

Kev ceev faj yuav tsum tau siv thaum tus neeg mob haus dej haus cawv tsis zoo, yog cov tshuaj tiv thaiv kab mob, muaj lub cev muaj zog ntau los yog pob txha pob txha suab qis, muaj kev tiv thaiv mob vwm, mob nyhav, mob ntshav khov, mob endocrine thiab cov teeb meem ntawm lub cev tsis ua mob. Kev Kho Mob yog nqa tawm ntawm cov neeg mob hnub nyoog tshaj 18 xyoo.

Thaum cev xeeb tub, nws yog qhov zoo dua rau qhov tsis kam lees siv tshuaj, txij li thaum hauv kev kho mob cov kev mob ntawm kev tsis tuaj yeem hauv menyuam yaus tom qab kev noj cov ntsiav tshuaj tas li.

Sab sij huam

Thaum muab tshuaj kho nrog tshuaj, tus kws kho mob yuav tsum xyuas kom tus neeg mob tsis noj lwm yam tshuaj. Tus neeg mob, nyeg, yuav tsum qhia tus kws kho mob txog yam tshuaj uas nws tau haus lawm. Qhov no yog qhov tsim nyog txhawm rau zam kom tsis txhob muaj kev sib cuam tshuam nrog qee yam tshuaj.

Tshwj xeeb, nrog kev siv cov tshuaj fibrates, cytostatics, kev txhaj tshuaj ntau ntawm nicotinic acid, Erythromycin, protease inhibitors, antifungal agents, immunosuppressants, Clarithromycin, rhabdomyolysis tuaj yeem tsim kho.

Vim tias muaj qhov cuam tshuam ntau ntxiv rau cov tshuaj tiv thaiv qhov ncauj, los ntshav yuav tshwm sim, yog li koj yuav tsum ua tib zoo saib xyuas lub xeev ntawm cov ntshav thaum kho. Simvagexal tseem nce cov plasma cov ntsiab lus ntawm digoxin. Yog tias tus neeg mob tau siv yav dhau los cholestyramine thiab colestipol, cov ntsiav tshuaj tau tso cai kom noj tsuas yog tom qab plaub teev.

1. Cov kev mob tshwm sim yog tshwm sim hauv daim ntawv ntawm cov leeg mob, asthenic syndrome, kiv taub hau, pom kev plooj plooj, txha caj dab, saj tsis zoo, mob taub hau, pw tsis tsaug zog, mob hlab ntsha hlwb ib ce.
2. Muaj qee tus mob ntawm lub plab zom mov tsis ua haujlwm, cem quav, xeev siab, dyspepsia, ntuav, mob plab, mob plab, mob ncauj plab, mob raws plab, kab mob siab.
3. Muaj qee zaus, muaj qhov tsis haum yog pom ntawm daim tawv nqaij khaus thiab ua pob liab, polymyalgia rheumatism, thrombocytopenia, kub taub hau, nce erythrocyte sedimentation tus nqi, urticaria, ua tsis taus pa, eosinophilia, angioedema, tawv nqaij hyperemia, vasculitis, mob caj dab, lupus erythematosus, thiab lupus.
4. Ib tus neeg tuaj yeem pom myalgia, myopathy, feem ntau tsis muaj zog, rhabdomyolysis. Raws li qhov tshwm sim, potency tsawg dua, palpitations nce ntxiv, anemia pib, thiab mob siab tsis ua haujlwm.

Yog tias muaj kev noj ntau dhau, raws li txoj cai, cov tsos mob tshwj xeeb tsis tshwm sim, tab sis nws yog ib qho tseem ceeb kom tshem tawm cov nquag siv tshuaj tawm hauv lub cev. Ua li no, tus neeg mob ntuav, muab cov pa hluav taws kom cig. Thaum kho, nws yog ib qhov tsim nyog los saib xyuas qib theem ntawm creatine phosphokinase, lub raum thiab hepatic kev ua haujlwm.

Yog tias koj noj cov tshuaj statins ntev ntev, hauv qee qhov tsis tshua muaj tshwm sim kab mob ntsws interstitial ntsws, uas nrog los ntawm tus neeg hnoos qhuav, ua rau mob ntawm tus mob, ua rau qaug zog, poob phaus, thiab ua daus no.

Cov kws kho mob Cov lus pom zoo

Yog hais tias ib tug neeg thaum lub sij hawm tus txheej txheem ntawm kev kho mob tsub kom ntau cov kev ua ntawm creatine phosphokinase thiab cov leeg mob tuaj, nws yog qhov tsim nyog los tso tseg kev tawm dag zog lub cev.

Nws kuj tseem yuav tsum tshem tawm cov teeb meem uas ua rau muaj enzyme nce ntxiv, uas suav nrog kev ua npaws, nqaij doog, kev raug mob, hypothyroidism, kis mob, carbon dioxide lom, polymyositis, dermatomyositis, cawv thiab quav yeeb tshuaj. Yog tias tom qab qhov kev ua haujlwm enzyme txuas ntxiv nce ntxiv, Simvagexal ntsiav tshuaj yuav tsum tau tso tseg tag nrho.Txhua, koj tuaj yeem siv analogues los ntawm lwm cov tuam ntxhab.

Ua ntej pib txoj kev kho mob, tus kws kho mob yuav tsum ua qhov kev sim ntshav rau KFK cov haujlwm. Cov txheej txheem no yuav tsum rov ua tom qab peb lub hlis. Kev soj ntsuam ntawm creatine phosphokinases nyob rau hauv cov neeg laus thiab cov neeg mob nrog kev kuaj mob ntawm insulin-tiv thaiv cov ntshav qab zib mellitus, hypothyroidism, lub raum tsis ua haujlwm tau nqa tawm hauv lub xyoo.

Rau txhua yam ntshav qab zib, nws yog ib qho tsim nyog yuav tsum tau ntsuas cov ntshav qabzib tas li, vim tias cov tshuaj yuav pab txhawb ntxiv cov ntshav qab zib hauv cov ntshav.

Qee tus neeg mob tau txhim kho hyperglycemia, uas yuav tsum tau noj tshuaj tshwj xeeb.

Tab sis cov kws kho mob tsis pom zoo kom tsis txhob siv cov tshuaj statins, vim tias kev nce roj ntau tuaj yeem ua rau muaj teeb meem loj dua rau cov neeg mob ntshav qab zib yog tias lawv tsis kho kom zoo.

Cov ntsiav tshuaj yuav tsum tau ua nrog ceev faj yog tias tus neeg mob haus dej cawv. Yog tias muaj kev txo qis hauv cov thyroid ua haujlwm, mob raum, kab mob tseem ceeb tau kho ua ntej, tsuas yog tom qab ntawd koj tuaj yeem pib txo qis cov concentration ntawm cov roj cholesterol hauv cov ntshav.

Cov tshuaj zoo ib yam xws li Zokor, Avestatin, Sinkard, Simgal, Vazilip, Aterostat, Zorstat, Avenkor, Holvasim, Simplakor, Actalipid, Zovatin thiab lwm yam.

Kev noj tshuaj kom txo qis cov roj (cholesterol)

Ntxiv nrog rau kev noj tshuaj, tus neeg mob yuav tsum ua raws li kev noj zaub mov hypocholesterol, uas muaj nyob hauv kev noj cov zaub mov uas muaj tsiaj ntau. Cov khoom noj kom tsim nyog tuaj yeem txhim kho lub xeev ntawm cov hlab ntsha thiab tau tshem ntawm cov kab mob atherosclerotic plaques.

Cov zaub mov txwv tsis pub muaj cov rog thiab roj refractory, cov roj ntuj, cov roj qab rog, cov rog rog, cov nqaij hnyuv ntxwm, thiab hnyuv ntxwm. Tus neeg mob yuav tsum tsis kam noj qe qe, kib qos yaj ywm, pancakes, pastries thiab cream confectionery.

Tsis tas li ntawd, yuav tsum tsis suav cov kua ntsw, cov mis nyuj, kua mis, qab zib, qaub cream, rog tsev cheese yuav tsum yog los ntawm cov khoom noj.

Nws raug nquahu kom tus neeg mob lub tais diav nrog taum, canola, txiv ntseej, noob hnav thiab lwm cov roj zaub, uas muaj cov omega-fatty fatty acids.

Koj yuav tsum nquag noj ntses salmon, ntses tsaj, mackerel thiab lwm yam ntau yam ntawm cov rog rog, nqaij ntshiv, nqaij qaib, qaib ntxhw. Xws li cov khoom noj yog qhov zoo tshaj plaws ntawm cov protein.

Cov zaub mov muaj cov npluag ua zaub ua mov rau hauv dej, kua mov ci tag nrho, zaub ntau yam, zaub tshiab thiab txiv hmab txiv ntoo.

Nrog ntshav qab zib ntawm txhua hom, koj tuaj yeem ua tsis raug cai ua khoom qab zib, pies, biscuits.

Kev noj zaub mov noj kom zoo nrog kev ua kom rog hauv cov ntshav muaj ntau txoj cai yooj yim uas yuav tsum ua raws. Cov dej cawv, kas fes, muaj cov tshuaj yej muaj zog yog cov khoom tiv thaiv tag nrho, cov zaub mov qab zib thiab hmoov txhuv nplej siab tau siv hauv qhov tsawg tsawg.

Cov zaub mov suav nrog zaub, txiv hmab txiv ntoo, cov zaub mov tsis muaj roj. Cov khoom noj uas kib yog pauv los ntawm cov khoom noj siav thiab ci. Siav cov nqaij siav tau noj kom txias kom txias uas tsis muaj rog dhau los. Nqaij qaib ua-ua noj nyob ntawm lub rooj tsis muaj tawv nqaij, rog yuav tsis siv rau thaum ua zaub mov noj. Nqaij qaib ua tau noj yam tsis tau yolks.

Noj zaub mov kom zoo yuav daws cov roj cholesterol ntau, tiv thaiv cov hlab ntsha thiab daim siab. Hauv thawj xya hnub, tus neeg mob tau zoo me ntsis, vim lub plab zom mov tsis zoo rau kev ntxhov siab. Xws li cov zaub mov noj tsis muaj contraindications, vim nws yog sib npaug, yog li nws yog qhov zoo rau cov neeg mob ntshav qab zib.

Yuav ua li cas li cas rau cov roj ntsha tsis sib haum ntawm lipid yog tau piav hauv video hauv tsab xov xwm no.

Qhia koj qab zib lossis xaiv tus tub los ntxhais rau cov lus pom zoo Nrhiav pom tsis pom Nrhiav tsis pom Nrhiav tsis pom

SIMVAGEXAL

- thawj hypercholesterolemia (hom IIa thiab IIb raws li Fredrickson kev faib tawm) nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov noj nrog cov roj (cholesterol) thiab lwm yam kev ntsuas tsis muaj tshuaj (kev tawm dag zog thiab kev poob phaus) hauv cov neeg mob uas muaj kev pheej hmoo mob ntshav siab (atherosclerosis), - ua ke hypercholesterolemia thiab hypertriglyceridemia, tshwj xeeb kev noj haus thiab kev tawm dag zog, - IHD: tiv thaiv ntawm myocardial infarction (tiv thaiv kab mob ntawm myocardial infarction) hauv cov neeg mob uas muaj qib nce ntawm nqa tawm cov cholesterol (> 5.5 mmol / l).

Cov Tshuaj Pharmacokinetics

XuasQhov nqus ntawm simvastatin muaj ntau dua. Tom qab noj, Cmax hauv plasma tau mus txog tom qab kwv yees li 1.3-2.4 teev thiab txo li 90% tom qab 12 teev.Kev xa KhoomKev khi rau cov ntshav plasma protein yog li 95%.Kev zom zaub movNws hla ntawm cov nyhuv ntawm "thawj tshooj" los ntawm daim siab. Nws yog hydrolyzed los tsim ib qho kev nquag, beta-hydroxyacids, thiab lwm yam kev ua kom nquag plias thiab tsis muaj zog.Chaw Sau NtawvT1 / 2 ntawm cov tshuaj metabolites yog 1.9 teev .Nws yog tsuas yog nrog quav (60%) raws li cov tshuaj metabolites. Li ntawm 10-15% yog tawm los ntawm lub raum hauv daim ntawv ntawm kev siv lub cev tsis muaj zog.

Cov Yuav Tsum Muaj

- lub siab ua haujlwm, mob siab daim siab, ib qho kev pheej hmoo ntawm kev ua haujlwm ntawm hepatic transaminases ntawm cov tsis paub txog etiology, - porphyria, - myopathy, - ib txhij tswj hwm ntawm ketoconazole, itraconazole, tshuaj rau kev kho mob HIV, - nce rhiab heev rau cov tshuaj feem, tus lej (rau cov tshuaj tiv thaiv ntawm HMG-CoA reductase) hauv keeb kwm. ceev faj cov tshuaj yuav tsum raug kho rau cov neeg mob uas muaj cawv cawv ntev ntev, cov neeg mob tom qab hloov khoom nruab nrog, uas tau kho tshuaj tiv thaiv kab mob (vim tias muaj mob rhabdomyolysis thiab mob raum tsis zoo), hauv cov xwm txheej uas tuaj yeem ua rau lub raum tsis ua haujlwm, xws li mob ntshav siab, mob sib kis. cov kab mob loj heev, cov teeb meem loj hauv lub cev thiab cov endocrine muaj kev cuam tshuam, cuam tshuam hauv dej-electrolyte tshuav, kev phais mob. (suav nrog kev kho hniav) lossis raug mob rau cov neeg mob uas txo lossis nce ntxiv ntawm pob txha pob txha pob txha ntawm cov neeg tsis paub tus mob, nrog rau kev mob vwm, menyuam yaus thiab tub ntxhais hluas uas muaj hnub nyoog qis dua 18 xyoo (kev nyab xeeb thiab kev ua tau zoo tsis tau tsim).

Cov lus qhia rau kev siv

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoomCoated ntsiav tshuaj lub teeb daj, oval, convex, nrog ib qho kev ceeb toom ntawm ib sab thiab sau "SIM 5" ntawm lwm qhov, ntawm lub kink - dawb.Cov muaj tswv yim: hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, titanium dioxide, oxide daj oxide li 10 pcs. - hlwv (3) - pob khoom los ntawm cardboard.Coated ntsiav tshuaj lub teeb paj yeeb dawb, oval, convex, nrog ib qho kev ceeb toom ntawm ib sab thiab sau "SIM 10" ntawm lwm qhov, ntawm lub kink - dawb.Cov muaj tswv yim: hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, titanium dioxide, hlau oxide liab, hlau oxide daj li 10 pcs. - hlwv (3) - pob khoom los ntawm cardboard.Coated ntsiav tshuaj lub teeb txiv kab ntxwv, oval, convex, nrog ib qho kev ceeb toom rau ntawm ib sab thiab sau ntawv "SIM 20" ntawm lwm qhov, ntawm lub kink - dawb.Cov muaj tswv yim: hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, titanium dioxide, hlau oxide liab, hlau oxide daj li 10 pcs. - hlwv (3) - pob khoom los ntawm cardboard.Coated ntsiav tshuaj dawb los yog yuav luag dawb, kheej li lub qw, convex, nrog ib qho kev ceeb toom ntawm ib sab thiab sau "SIM 30" nyob rau lwm qhov, ntawm lub kink - dawb.Cov muaj tswv yim: hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, titanium dioxide 10 pcs. - hlwv (3) - pob khoom los ntawm cardboard.Coated ntsiav tshuaj liab dawb, oval, convex, nrog ib qho kev ceeb toom ntawm ib sab thiab sau "SIM 40" ntawm ib sab, rau ntawm lub kink - dawb.Cov muaj tswv yim: hmoov txhuv nplej siab, lactose monohydrate, microcrystalline cellulose, butyl hydroxyanisole, ascorbic acid, citric acid monohydrate, magnesium stearate, hypromellose, talc, titanium dioxide, liab hlau oxide .10 pcs. - hlwv (3) - pob khoom los ntawm cardboard.Cov chaw kho mob thiab chaw muag tshuaj: Cov tshuaj tiv thaiv hypolipidemicSau Npe No№:

Dosage daim ntawv

Zaj duab xis-coated ntsiav tshuaj.

1 lub ntim zaj duab xis-txheej muaj:
Lub ntsiab ntawm cov ntsiav tshuaj:cov tshuaj nquag: simvastatin 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40.00 mg tus zam: Pregelatinized hmoov txhuv nplej siab 10.00 mg / 20.00 mg / 40.00 mg / 60.00 mg / 80.00 mg, lactose monohydrate 47.60 mg / 95.20 mg / 190.00 mg / 286.00 mg / 381 , 00 mg, microcrystalline cellulose 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40.00 mg, butylhydroxyanisole 0.01 mg / 0.02 mg / 0.04 mg / 0.06 mg / 0.08 mg, ascorbic acid 1.30 mg / 2.50 mg / 5.00 mg / 7.50 mg / 10.00 mg, citric acid monohydrate 0.63 mg / 1.30 mg / 2.50 mg / 3.80 mg / 5.00 mg, magnesium stearate 0.50 mg / 1.00 mg / 2.00 mg / 3.00 mg / 4.00 mg,
Plhaub: hypromellose-5 cps 0.35 mg / 0.70 mg / 1.50 mg / 2.00 mg / 3.00 mg, hypromellose-15 cps 0.53 mg / 1.10 mg / 2.30 mg / 3, 00 mg / 4.50 mg, talc 0.16 mg / 0.32 mg / 0.69 mg / 0.90 mg / 1.40 mg, titanium dioxide (E171) 0.40 mg / 0.80 mg / 1 , 70 mg / 2.30 mg / 3.4 mg, daj xim hlau oxide zas 0.0043 mg / 0.0017 mg / 0.11 mg / - / -, hlau xim oxide liab ziab - / 0.0043 mg / 0.026 mg / - / / 0.14 mg.

Kev piav qhia

Oval, ntsiav tshuaj biconvex, zaj duab xis-txheej, nrog ib qho nqis siab ntawm ib sab thiab tus txaug rau sab nraud, nrog ob sab kev pheej hmoo. Tus ntoo khaub lig yog dawb.
Dosage 5 mg: ntsiav tshuaj ntawm lub teeb daj xim nrog engraving "SIM 5".
Dosage 10 mg: ntsiav tshuaj ntawm lub teeb liab xim nrog engraving "SIM 10".
Dosage 20 mg: ntsiav tshuaj ntawm lub teeb txiv kab ntxwv xim nrog engraving "SIM 20".
Dosage 30 mg: Ntsiav tshuaj dawb los yog yuav luag xim dawb nrog engraving "SIM 30".
Dosage 40 mg: ntsiav tshuaj liab ntsiav nrog engraving "SIM 40".

Siv thaum cev xeeb tub thiab thaum pub niam mis

Kev siv cov tshuaj SimvAGEXAL ® thaum cev xeeb tub yog contraindicated.
Vim tias qhov tseeb tias HMG-CoA reductase inhibitors inhibit cov synthesis ntawm cov roj cholesterol, thiab cov roj cholesterol thiab lwm cov khoom ntawm nws cov synthesis ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov menyuam hauv plab, suav nrog kev sib xyaw ntawm cov tshuaj steroids thiab cell cell, simvastatin yuav muaj qhov tsis zoo ntawm tus me nyuam hauv plab thaum siv hauv cov poj niam cev xeeb tub ( Cov poj niam ntawm kev muaj me nyuam hnub nyoog yuav tsum zam qhov tsis muaj menyuam). Yog tias cev xeeb tub tshwm sim thaum kho, qhov tshuaj yuav tsum tsis ua ntxiv, thiab tus poj niam yuav tsum ceeb toom tias muaj kev phom sij rau lub cev xeeb tub.
Kev tshem tawm cov tshuaj lipid-txo qis thaum lub cev xeeb tub tsis cuam tshuam loj heev ntawm kev kho mob mus ntev ntawm cov thawj hypercholesterolemia.
Tsis muaj ntaub ntawv qhia txog kev tso tawm ntawm simvastatin mus rau hauv niam cov kua mis, yog li thaum siv cov tshuaj thaum lactation, kev pub mis niam yuav tsum tau tso tseg.

Tsuas tshuaj thiab tswj hwm

Ua ntej pib txoj kev kho mob nrog SimvAGEXAL ®, tus neeg mob yuav tsum tau noj tshuaj kom tsis txhob mob hypocholesterolemic noj, uas yuav tsum tau ua raws li thoob plaws hauv lub sijhawm kho.
SimvAGEXAL ® ntsiav tshuaj noj ib hnub ib zaug, thaum yav tsaus ntuj, muaj dej ntau.
Pom zoo koob tshuaj txhua hnub yog li ntawm 5 txog 80 mg.
Kev noj tshuaj titration yuav tsum tau ua ntawm kev ncua sijhawm ntawm 4 lub lis piam.
Ib koob tshuaj ntawm 80 mg tuaj yeem siv rau hauv cov neeg mob uas muaj mob hypercholisterinemia siab thiab muaj kev pheej hmoo siab ntshav siab xwb.
Cov neeg mob nrog tsev neeg homozygous hypercholesterolemia: cov koob tshuaj pom zoo txhua hnub yog 40 mg rau ib hnub, ib zaug thaum yav tsaus ntuj. Qhov koob tshuaj 80 mg ib hnub twg tsuas pom zoo tsuas yog tias cov txiaj ntsig zoo ntawm txoj kev kho tshaj qhov kev pheej hmoo txaus. Hauv cov neeg mob no, cov tshuaj SimvAGEXAL ® yog siv ua ke nrog lwm txoj kev kho mob lipid-piv txwv (piv txwv li, LDL plasmapheresis) lossis tsis muaj kev kho mob, yog tias tsis muaj.
Cov neeg mob nrog ischemic mob plawv lossis muaj kev pheej hmoo siab ntawm cov kab mob plawv
Tus txheej txheem thawj zaug ntawm SimvAGEXAL ® rau cov neeg mob uas muaj kev pheej hmoo loj ntawm lub plawv mob ua ke nrog lossis tsis muaj hyperlipidemia (nyob rau hauv cov ntshav qab zib mellitus, keeb kwm ntawm mob stroke lossis lwm yam kab mob cerebrovascular, keeb kwm ntawm tus kab mob plawv), zoo li rau cov neeg mob uas muaj mob rau cov leeg ntshav yog 40 mg ib hnub Cov.
Cov neeg mob uas muaj hyperlipidemia uas tsis muaj qhov phom sij saum toj no: Qhov qauv pib noj tshuaj yog 20 mg ib hnub ib zaug thaum yav tsaus ntuj.
Hauv cov neeg mob uas muaj cov ntshav ntshiab LDL concentration uas yog 45% siab dua qhov ib txwm, thawj koob yuav tsum yog 40 mg / hnub. Rau cov neeg mob uas mob me mus rau hypercholesterolemia, kev kho mob nrog SimvAGEXAL ® tuaj yeem pib nrog qhov pib ntawm 10 mg / hnub.
Hloov kho ntau yam: SimvAGEXAL ® tuaj yeem siv tau ob qho tib si hauv monotherapy thiab hauv kev sib xyaw nrog bile acid sequestrants.
Rau cov neeg mob noj fibrates tib lub sijhawm, Ntxiv rau fenofibrate, qhov siab tshaj plaws niaj hnub noj ntawm simvastatin yog 10 mg. Concomitant siv nrog gemfibrozil yog contraindicated.
Hauv cov neeg mob tib lub sijhawm noj verapamil, diltiazem, thiab dronedarone, koob tshuaj ntau tshaj txhua hnub yog 10 mg / hnub.
Rau cov neeg mob ib txhij noj amiodarone, amlodipine, ranolazine, qhov siab tshaj plaws txhua hnub koob tshuaj simvastatin yog 20 mg.
Cov neeg mob raum tsis ua haujlwm: hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm me me mus rau mob hnyav me me (CC ntau dua 30 ml / min) tsis tas yuav tsum kho kom haum. Hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm ntawm qhov mob hnyav (CC tsawg dua 30 ml / min) lossis noj cov tshuaj fibrates lossis nicotinic acid (ntawm ib koob ntau dua 1 g / hnub), qhov pib koob yog 5 mg thiab qhov siab tshaj plaws tau tso cai txhua hnub yog 10 mg.
Hauv cov neeg mob laus (tshaj 65 xyoo) Tsis tas yuav txhaj koob tshuaj.
Siv rau hauv cov menyuam yaus thiab cov hluas thaum muaj hnub nyoog 10-17 xyoo nrog kev tso ntshav siab rau tsev neeg: Qhov pom zoo kom pib noj yog 10 mg rau ib hnub nyob rau yav tsaus ntuj. Qhov pom zoo muab tshuaj yog 10 - 40 mg rau ib hnub, qhov siab tshaj plaws kev pom zoo ntawm cov tshuaj yog 40 mg rau ib hnub. Kev xaiv koob tshuaj yog nqa tawm ib tus zuj zus raws li cov hom phiaj kho.
Yog tias tsis nco lub tshuaj tam sim no, cov tshuaj yuav tsum ua kom sai li sai tau. Yog tias nws txog lub sijhawm yuav rov qab noj tshuaj ntxiv, qhov koob tshuaj yuav tsum tsis txhob suav ntxiv.

Sab sij huam

Raws li Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (WHO), tsis xav tau cov dej num yog faib raws li lawv qhov kev loj hlob raws li hauv qab no: feem ntau (/1 / 10), feem ntau (los ntawm ≥1 / 100 mus rau qhov tsis txaus ntseeg ntawm cov ntshav thiab cov leeg ntshav)
tsis tshua muaj: anemia (suav nrog hemolytic), thrombocytopenia, eosinophilia.
Kev tsis taus ntawm lub paj hlwb
tsis tshua muaj: kiv taub hau, mob taub hau, mob caj dab, mob ib ce neuropathy,
Tsis tshua muaj: kev pw tsaug zog tsis meej (insomnia, "npau suav phem" npau suav), kev nyuaj siab, nco ploj lossis ploj, plooj tsis pom kev.
Kev ua tsis taus ntawm lub tshuab ua pa, hauv siab thiab mediastinal plab hnyuv siab raum
feem ntau: sab sauv ntawm txoj hlab ua pa tuaj
tsis paub zaus: interstitial mob ntsws (tshwj xeeb nrog rau kev siv ntev), mob ntsws, mob ntsws.
Lub siab tsis zoo
feem ntau: atrial fibrillation.
Kev mob plab zom mov
feem ntau: mob plab
tsis tshua muaj: cem quav, mob plab, xeev siab, ntuav, raws plab, pom pob, mob caj pas.
Kev ua txhaum ntawm daim siab thiab paum nkag
tsis tshua muaj: kab mob siab, daj ntseg,
Tsis tshua muaj: neeg tuag taus thiab lub siab tsis ua hauj lwm.
Kev ua mob ntawm daim tawv nqaij thiab cov nqaij mos
tsis tshua muaj: tawv nqaij ua pob khaus, ua pob khaus ntawm daim tawv nqaij, alopecia, photosensitivity.
Musculoskeletal thiab sib txuas ntawm cov nqaij mos tsis zoo
tsis tshua muaj: myopathy * (suav nrog myositis), rhabdomyolysis (nrog lossis tsis muaj kev txhim kho ntawm lub raum tsis ua haujlwm), myalgia, mob leeg mob, polymyositis,
Tsis tshua muaj: mob caj dab, mob caj dab,
tsis paub zaus: tendinopathy, tejzaum muaj nrog cov leeg txhaws.
* Hauv qhov kev tshawb fawb soj ntsuam, myopathy tau pom ntau dua hauv cov neeg mob siv simvastatin ntawm 80 mg / hnub, piv nrog cov neeg mob siv 20 koob tshuaj / hnub (1.0% piv rau 0.02%, feem).
Ua txhaum ntawm lub raum thiab mob txeeb zig
tsis paub zaus: mob raum tsis ua haujlwm (vim yog mob rhabdomyolysis), mob txeeb zig.
Kev ua txhaum ntawm cov qau thiab lub caj pas
tsis paub zaus: erectile kawg, gynecomastia.
Kev cuam tshuam dav dav thiab cuam tshuam ntawm qhov chaw txhaj tshuaj
tsis tshua muaj: feem ntau tsis muaj zog.
Kev ua xua tsis haum
tsis tshua muaj: angioedema, polymyalgia rheumatica, vasculitis, ntau ntxiv erythrocyte sedimentation tus nqi (ESR), muaj cov tshuaj tiv thaiv kab mob siab, mob tawv nqaij ntawm lub ntsej muag, hyperemia, mob ntsws mob ntshav qab zib, ua rau lub cev tsis txaus, ua kom tsis tuaj yeem, tsis paub tseeb: tshuaj tiv thaiv kab mob necrotizing myopathy, mob ua paug rau cov leeg mob (mob ntshav qab zib) suav nrog Stevens-Johnson mob.
Cov ntaub ntawv kuaj thiab ntsuas
tsis tshua muaj: nce kev ua haujlwm ntawm "kab mob siab" transaminases, CPK thiab alkaline phosphatase hauv cov ntshav ntshav, tsis paub ntau npaum li cas: nce siab ntawm glycosylated hemoglobin, hyperglycemia.
Thaum siv lwm cov statins, cov xwm txheej hnyav ntxiv hauv qab no tau sau cia:
• nco ploj
• kev txawj xav
• mob ntshav qab zib mellitus. Qhov ntau zaus ntawm kev txhim kho cov ntshav qab zib yog nyob ntawm qhov muaj kev pheej hmoo txaus ntshai (ceev cov ntshav qabzib siab ntau dua 5.6 mmol / l, lub cev ntawm lub cev qhov ntau tshaj 30 kg / m², nce thyroglobulin (TG) concentration hauv cov ntshav ntshav, keeb kwm txog kev kub siab).
Cov menyuam yaus thiab tub ntxhais hluas (10-17 xyoo)
Raws li txoj kev tshawb no kav ntev dua 1 xyoos hauv cov menyuam yaus thiab cov hluas (cov tub hauv Tanner II theem thiab saum toj no thiab cov menyuam ntxhais yam tsawg kawg ib xyoos tom qab thawj zaug poj niam) muaj hnub nyoog 10-17 xyoo nrog heterozygous tsev neeg hypercholesterolemia (n = 175), kev nyab xeeb thiab tiv taus kev mob hauv pab pawg simvastatin, qhov profile ntawm cov pab pawg placebo tau zoo sib xws.
Cov xwm txheej uas nquag pom tshwm sim tshaj yog mob txha caj qaum, mob taub hau, mob plab, thiab xeev siab. Lub sijhawm ntev tsis cuam tshuam ntawm lub cev, kev txawj ntse, thiab kev sib deev yog tsis paub. Lub sijhawm no (ib xyoos tom qab kho) muaj cov ntaub ntawv muaj kev nyab xeeb tsis txaus.

Noj ntau dhau

Txog hnub, tsis muaj cov tsos mob tshwj xeeb ntawm kev siv tshuaj ntau dhau (qhov siab tshaj plaws yog 3.6 g) tau pom.
Kev Kho Mob: mob kev kho mob. Cov tshuaj tiv thaiv tshwj xeeb tsis tau paub.

Kev cuam tshuam nrog lwm yam tshuaj

Txoj kev kawm txog kev cuam tshuam nrog lwm cov tshuaj tau ua rau cov laus xwb.
Kev sib txuam ntawm tus kws muag tshuaj
Kev cuam tshuam nrog lwm cov lipid-txo cov tshuaj uas yuav ua rau muaj kev pheej hmoo ntawm myopathy / rhabdomyolysis
Fibrates
Txoj kev pheej hmoo ntawm kev tsim myopathy, suav nrog rhabdomyolysis, nce ntxiv thaum tib lub sijhawm siv simvastatin nrog fibrates.
Sib koom siv nrog gemfibrozil ua rau muaj kev nce ntxiv hauv cov ntshav concentration ntawm simvastatin, yog li lawv txoj kev siv ua ke yog contraindicated.
Tsis muaj pov thawj ntxiv ntawm kev pheej hmoo ntawm myopathy nrog kev siv simvastatin thiab fenofibrate.
Txoj kev kawm tswj hwm ntawm kev sib cuam tshuam nrog lwm cov khoom siv fibrates tsis ris tawm.
Nicotinic acid
Muaj ob peb daim ntawv tshaj tawm txog kev txhim kho myopathy / rhabdomyolysis nrog kev siv simvastatin thiab nicotinic acid ntau ntau hauv ib qho lipid-txo cov tshuaj (ntau dua 1 g / hnub).
Fusidic acid
Txoj kev pheej hmoo ntawm kev tsim myopathy nce nrog kev siv fusidic acid nrog rau statins, suav nrog simvastatin. Yog tias nws tsis tuaj yeem ua rau qee qhov laj thawj kom zam kev siv simvastatin nrog fusidic acid, nws pom zoo kom koj xav txog kev kho mob qeeb nrog simvastatin. Yog tias tsim nyog, lawv siv tib lub sijhawm, cov neeg mob yuav tsum tau saib xyuas zoo.
Pharmacokinetic sib cuam tshuam
Cov lus pom zoo rau kev siv tshuaj sib txuam tau muab rau hauv rooj.

Kev Sib Cuam Tshuam Hauv Tshuaj Nrog txuam nrog Kev Raug Mob Tshaj Plaws Ntawm Myopathy / Rhabdomyolysis

Cov nyhuv ntawm lwm cov tshuaj rau ntawm pharmacokinetics ntawm simvastatin
Cov tshuaj tiv thaiv muaj zog ntawm isoenzyme CYP3A4
Simvastatin yog lub cev dej ntawm CYP3A4 isoenzyme. Cov tshuaj tiv thaiv muaj zog ntawm CYP3A4 isoenzyme nce ntawm kev pheej hmoo ntawm myopathy thiab rhabdomyolysis los ntawm kev ua kom lub zog ntawm HMG-CoA reductase nyob rau hauv cov ntshav ntshav thaum kho nrog simvastatin. Cov tshuaj tiv thaiv no suav nrog itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors (e.g. nelfinavir), boceprevir, telaprevir, thiab kuj nefazodone.
Kev siv tib lub sijhawm simvastatin nrog itraconazole, ketoconazole, posaconazole, erythromycin, clarithromycin, telithromycin, HIV tiv thaiv inhibitor (e.g. nelfinavir), zoo li nefazodone, yog contraindicated. Yog tias rau qee qhov laj thawj nws tsis tuaj yeem zam kom tsis txhob muaj kev siv tshuaj simvastatin nrog cov tshuaj saum toj no, tom qab ntawd kev kho mob nrog simvastatin yuav tsum tau muab ncua kom txog rau thaum kawg ntawm qhov kawg ntawm kev kho nrog cov tshuaj no.
Simvastatin yuav tsum siv nrog ceev faj nrog qee qhov muaj zog dua CYP3A4 inhibitors: fluconazole, verapamil, lossis diltiazem.
Fluconazole
Cov xwm txheej tsis tshua muaj mob rhabdomyolysis cuam tshuam nrog kev siv simvastatin thiab fluconazole tib lub sijhawm.
Cyclosporin
Kev siv tib lub sijhawm ntawm cyclosporine thiab simvastatin yog contraindicated.
Danazole
Txoj kev pheej hmoo ntawm kev tsim myopathy / rhabdomyolysis nce nrog kev siv sib txuam ntawm kev seev cev, tshwj xeeb tshaj yog siv tshuaj ntawm simvastatin.
Amiodarone
Txoj kev pheej hmoo ntawm kev tsim myopathy thiab rhabdomyolysis nce nrog kev siv tib lub sijhawm ntawm amiodarone nrog kev sim siab ntau ntawm simvastatin. Hauv cov kev tshawb fawb soj ntsuam, kev txhim kho myopathy tau pom nyob rau hauv 6% ntawm cov neeg mob uas tau siv simvastatin ntawm ib koob ntawm 80 mg rau hauv kev sib xyaw nrog amiodarone. Yog li, cov koob tshuaj simvastatin yuav tsum tsis pub tshaj 20 mg rau ib hnub hauv cov neeg mob siv cov tshuaj nrog amiodarone tib lub sijhawm, yog tias cov txiaj ntsig kho tau tshaj li qhov pheej hmoo ntawm kev txhim kho myopathy thiab rhabdomyolysis.
Qeeb Calcium Channel Blockers
Verapamil
Txoj kev pheej hmoo ntawm kev tsim myopathy thiab rhabdomyolysis nce nrog kev siv verapamil nrog simvastatin hauv koob tshuaj ntau dua 40 mg. Cov koob tshuaj simvastatin yuav tsum tsis pub ntau dua 10 mg rau ib hnub hauv cov neeg mob siv cov tshuaj ib txhij nrog verapamil, yog tias cov kev pabcuam tau txais txiaj ntsig ntau dhau ntawm kev pheej hmoo ntawm kev txhim kho myopathy thiab rhabdomyolysis.
Diltiazem
Txoj kev pheej hmoo ntawm kev tsim myopathy thiab rhabdomyolysis nce ntxiv nrog kev siv diltiazem thiab simvastatin hauv ib koob ntawm 80 mg. Nrog rau kev siv simvastatin hauv ib koob tshuaj 40 mg nrog diltiazem, kev pheej hmoo ntawm kev tsim myopathy tsis tau nce ntxiv. Cov koob tshuaj simvastatin yuav tsum tsis pub tshaj 10 mg rau ib hnub hauv cov neeg mob siv cov tshuaj nrog diltiazem tib lub sijhawm, yog tias cov kev kho mob tau txais txiaj ntsig dhau qhov kev pheej hmoo ntawm kev tsim myopathy / rhabdomyolysis.
Amlodipine
Cov neeg mob siv amlodipine txuas nrog simvastatin ntawm ib koob ntawm 80 mg yog qhov muaj kev pheej hmoo ntawm kev tsim myopathy. Nrog rau kev siv simvastatin ua ke nyob rau hauv ib koob tshuaj 40 mg nrog amlodipine, qhov kev pheej hmoo ntawm kev tsim myopathy tsis tau nce ntxiv. Nrog rau kev siv simvastatin sib xyaw nrog amlodipine, koob tshuaj simvastatin yuav tsum tsis pub tshaj 20 mg rau ib hnub, yog tias cov kev pabcuam hauv tsev kho mob tau txais ntau dua qhov kev pheej hmoo ntawm kev txhim kho myopathy / rhabdomyolysis.
Lomitapid
Txoj kev pheej hmoo ntawm kev tsim myopathy / rhabdomyolysis tuaj yeem nce ntxiv nrog kev siv lomitapide nrog simvastatin tib txhij.
Lwm cov kev sib cuam tshuam
Cov txiv kab ntxwv qaub
Cov kua txiv ua kua txiv hmab txiv ntoo muaj ib lossis ntau qhov sib xyaw uas txwv CYP3A4 isoenzyme thiab tuaj yeem ua rau lub plasma concentration ntawm cov tshuaj metabolized los ntawm CYP3A4 isoenzyme. Thaum haus kua txiv hauv cov nyiaj ib txwm (ib khob 250 ml ib hnub), cov nyhuv no tsawg heev (nce ntxiv 13% hauv kev ua haujlwm ntawm HMG-CoA reductase inhibitors, kwv yees los ntawm thaj chaw hauv qab nkhaus-sijhawm nkhaus) thiab tsis muaj qhov tseem ceeb hauv chaw kho mob. Txawm li cas los xij, kev noj ntawm cov txiv kab ntxwv kua txiv hauv ntau qhov ntau (ntau dua li 1 liter ib hnub) ua rau muaj ntshav nce siab ntau ntawm kev ua haujlwm ntawm HMG-CoA reductase inhibitors thaum kho nrog simvastatin. Hauv qhov no, nws yog ib qho tsim nyog kom tsis txhob noj cov kua txiv kab ntxwv qaub rau hauv qhov loj.
Colchicine
Muaj cov ntawv tshaj tawm txog kev txhim kho myopathy / rhabdomyolysis nrog kev siv tib lub sijhawm ntawm colchicine thiab simvastatin hauv cov neeg mob uas mob raum tsis ua haujlwm. Cov neeg mob siv cov tshuaj no nyob rau tib lub sijhawm yuav tsum yog nyob ntawm kev saib xyuas los ntawm kws kho mob.
Rifampicin
Txij li thaum rifampicin yog qhov muaj zog ntau ntawm CYP3A4 isoenzyme, hauv cov neeg mob noj cov tshuaj no ntev (piv txwv, hauv kev kho mob ntsws), tej zaum yuav tsis muaj kev ua tau zoo ntawm kev siv simvastatin (tsis muaj kev ua tiav lub hom phiaj plasma cholesterol concentration).
Qhov cuam tshuam ntawm simvastatin rau ntawm pharmacokinetics ntawm lwm yam tshuaj
Simvastatin tsis inhibit CYP3A4 isoenzyme. Yog li, nws tau kwv yees tias simvastatin tsis cuam tshuam rau lub plasma concentration ntawm cov tshuaj metabolized los ntawm CYP3A4 isoenzyme.
Digoxin
Muaj cov lus hais tias nrog kev siv tib lub sijhawm ntawm digoxin thiab simvastatin, cov ntshav plasma concentration ntawm thawj nce ntau dua me ntsis, yog li, cov neeg mob noj digoxin yuav tsum ua tib zoo saib xyuas, tshwj xeeb tshaj yog thaum pib simvastatin txoj kev kho.
Indirect anticoagulants
Hauv ob qhov kev sim tshuaj, ib qho cuam tshuam nrog cov neeg tuaj yeem noj qab haus huv thiab lwm qhov cuam tshuam nrog cov neeg mob hypercholesterolemia, simvastatin ntawm ib koob ntawm 20-40 mg / hnub nruab nrab txhim kho cov nyhuv ntawm coumarin anticoagulants. Tus tseev tsim ntiaj teb li qub piv txwv (INR) nce ntawm 1.7-1.8 txog 2.6-3.4 hauv cov neeg tuaj noj qab haus huv thiab cov neeg mob, feem. Hauv cov neeg mob uas siv cov coumarin anticoagulants, lub sijhawm prothrombin (PV) lossis INR yuav tsum txiav txim siab ua ntej kev kho mob thiab, tom qab ntawd, feem ntau tau txiav txim siab thaum pib theem ntawm kev kho mob nrog simvastatin kom ntseeg tau tias tsis muaj qhov hloov pauv tseem ceeb hauv PV / INR. Thaum ruaj khov PV / INR tus nqi tau tsim tau, nws tuaj yeem soj ntsuam thaum lub sijhawm sib kis tau pom zoo rau cov neeg mob noj tshuaj coumarin anticoagulants. Thaum hloov cov koob tshuaj ntawm simvastatin, lossis cuam tshuam kev kho mob, qhov zaus ntawm kev tswj hwm ntawm PV / INR yuav tsum tau nce. Qhov tshwm sim ntawm kev los ntshav los yog kev hloov pauv hauv PV / INR hauv cov neeg mob uas tsis siv tshuaj anticoagulants tsis cuam tshuam nrog kev siv cov simvastatin.

Simvagexal: hais tias tsis muaj cov roj (cholesterol) siab

imvaghexal yog qhov tshuaj hypolipidemic raws li simvastatin.

Nws yog siv los kho cov neeg mob txhaws mob plawv thiab hypercholesterolemia.

Nws yog tshuaj rau cov neeg mob uas muaj hnub nyoog kaum yim xyoo, tshwj hauv cov neeg nrog contraindications.

Simvagexal faib tawm los ntawm cov khw muag tshuaj nrog cov tshuaj nojCov. Yog li, ua ntej koj yuav ib cov tshuaj, koj yuav tsum sab laj nrog kws kho mob.

Cov txheej txheem ua ntawv thov

Siv Simvagexal sab hauv, thiab tom qab ntawd mam li haus dej kom ntau. Zaus ntawm kev siv - ib zaug ib hnub. Lub sijhawm xav tau rau kev nkag mus yog yav tsaus ntuj. Lub sijhawm kho yog txiav txim siab ntawm tus kheej.

Yog tias tam sim no tu tsis tau, cov tshuaj raug coj tam sim. Txawm li cas los xij, tsis txhob txhaj ob koob yog tias nws txog sijhawm txog kev siv tshuaj ntxiv.

Thawj koob tshuaj rau kev kho mob hypercholesterolemia yog txiav txim siab los ntawm qhov mob hnyav thiab txawv ntawm 5 txog 10 mg / hnub. Cov koob tshuaj tau teem raws li ntshav theem ntshav ntawm cov roj cholesterol tau nrog lub sij hawm luv tsawg kawg plaub lub lis piam.

Cov qauv txheem tshuaj txhua hnub yog 40 mg. Yog tias tus neeg mob muaj lub plawv mob txaus thiab txoj kev kho mob tsis zoo txaus, tus kws kho mob yuav nce qhov ntau ntxiv rau 80 mg / hnub.

Thawj koob tshuaj rau CHD yog 20 mg. Yog tias tsim nyog, nce ntxiv rau 40 mg txhua plaub lub lis piam. Cov koob tshuaj ntawm cov tshuaj txo yog tias tag nrho cov roj cholesterol hauv qab poob qis dua 3.6 mmol / litre, thiab LDL cov ntsiab lus qis dua 1.94 mmol / litre.

Cov neeg mob tib txhij siv cov tshuaj cyclosporine, nicotinamide lossis fibrates xav tau kom txo qis qhov pib thiab ntau tshaj plaws tso cai rau txhua hnub rau 5 thiab 10 mg, feem. Tib yam mus rau cov neeg mob raum tsis ua haujlwm.

Qhov pom zoo thaum pib thiab qhov siab tshaj plaws txhua hnub rau kev txhaj tshuaj tiv thaiv kab mob yog 5 mg / hnub.

3. Kev Sau, tso daim foos

Cov tshuaj muaj simvastatin thiab cov tshuaj ntxiv, xws li lactose monohydrate, ascorbic acid, magnesium stearate, talc, hlau (III) oxide, pob kws hmoov txhuv nplej siab, hypromellose, citric acid monohydrate, titanium dioxide, MCC.

Simvagexal tawm hauv cov qauv ntawm cov kheej kheej cov ntsiav tshuaj nrog lub pleev xim rau xim, txheej txheej.

Cov xim ntawm lub plhaub tuaj yeem yog lub teeb daj (5 mg), lub teeb liab (10 mg), lub teeb txiv kab ntxwv (20 mg), xim dawb lossis yuav luag dawb (30 mg), thiab paj yeeb (40 mg). Ntawm ib sab ntawm cov ntsiav tshuaj yog sau tias “SIM 40”, “SIM 30”, “SIM 10”, “SIM 20” lossis “SIM 5” (nyob ntawm daim ntawv tso tawm).

5. Sab laj sab

Thaum cev xeeb tub

Cov neeg mob cev xeeb tub yuav tsum tsis txhob noj Simvagexal. Muaj cov ntawv tshaj tawm txog kev loj hlob hauv cov menyuam mos uas lawv niam coj simvastatin ntawm ntau yam txawv txav.

Yog tias tus poj niam ntawm lub hnub nyoog yug menyuam yuav tsum simvastatin, nws yuav tsum zam qhov tsis muaj menyuam. Yog tias cev xeeb tub tau tshwm sim thaum kho, Simvagexal yuav tsum tsis ua haujlwm ntxiv, thiab tus neeg mob yuav tsum ceeb toom tias yuav muaj kev phom sij rau tus menyuam hauv plab.

Tsis muaj ntaub ntawv hais txog kev faib nyiaj ntawm cov khoom siv txuam nrog niam mis. Yog tias koj tsis tuaj yeem zam qhov teem caij ntawm Simvagexal rau tus poj niam cev xeeb tub, koj yuav tsum qhia nws txog qhov xav tau kom tsis txhob pub mis niam.

Qhov kev ceev faj no tau cuam tshuam nrog qhov tseeb tias ntau cov tshuaj muaj nyob hauv cov mis, ua rau muaj kev pheej hmoo ntau ntxiv ntawm cov kev tawm tsam hnyav.

7. Cov lus thiab cov xwm txheej ntawm kev cia khoom

Simvagexal muab cia rau peb xyoos ntawm qhov kub txog 30 degrees lossis sib npaug nws.

Tus nqi nruab nrab ntawm simvageksal hauv Lavxias chaw muag tshuaj txuas ntxiv yog 280 p.

Rau cov neeg los ntawm Ukraine cov tshuaj raug nqi nruab nrab ntawm 300 UAH.

Cov npe ntawm Simvagexal analogues suav nrog cov tshuaj xws li Aterostat, Avestatin, Vazilip, Actalipid, Zokor, Vero-Simvastatin, Zorstat, Zovatin, Ariescor, Simvastatin, Simgal, Simvor, Simvastol, Holvasim, Sinkard, Simplakor thiab lwm yam.

Kev tshuaj xyuas txog cov tshuaj ntawm cov kws kho mob thiab cov neeg mob feem ntau zoo. Raws li lawv, simvagexal pab txo cov roj cholesterol thiab qhov kev pheej hmoo ntawm cov teeb meem cuam tshuam nrog kev ua haujlwm ntawm cov hlab plawv.

Mus rau qhov kawg ntawm tsab xov xwm los nyeem kev txheeb xyuas txog Simvageksal. Qhia seb koj xav li cas txog cov tshuaj yog tias koj yuav tsum noj nws lossis tshaj tawm nws rau cov neeg mob. Qhov no yuav pab lwm tus neeg tuaj saib lub site.

1. Thaum pib ntawm kev noj tshuaj, tshuaj hloov transaminase yog ua tau (ib qho kev hloov pauv hauv theem ntawm daim siab enzymes).
2. Simvagexal tsis noj rau qhov muaj kev pheej hmoo loj ntawm kev tsim muaj cov mob zoo li mob raum tsis ua haujlwm, rhabdomyolysis.

Sivastatin, tshuaj rau cov neeg mob cev xeeb tub, tuaj yeem muaj qhov tsis zoo ntawm cov menyuam hauv plab (cov poj niam uas muaj hnub nyoog yug yuav tsum zam kev muaj menyuam). Yog tias cev xeeb tub tau tshwm sim thaum kho, cov tshuaj yuav tsum tsis ua ntxiv, thiab tus neeg mob yuav tsum raug ceeb toom txog qhov kev phom sij tuaj yeem ua rau muaj menyuam hauv plab.

Cov ntawv no puas pab tau zoo? Tej zaum cov ntaub ntawv no yuav pab koj cov phooj ywg! Thov nyem rau ntawm ib lub nyees khawm:

Lub Npe Tsis Them Nyiaj Thoob Ntiaj Teb:

Zaj duab xis-coated ntsiav tshuaj.

1 lub ntim zaj duab xis-txheej muaj:
Ntsiav tshuaj tub ntxhais kawm: cov khoom xyaw ua haujlwm: simvastatin 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40.00 mg, zam tsis tau: pregelatinized hmoov txhuv nplej siab 10.00 mg / 20.00 mg / 40.00 mg / 60.00 mg / 80.00 mg, lactose monohydrate 47.60 mg / 95.20 mg / 190.00 mg / 286.00 mg / 381.00 mg, microcrystalline cellulose 5.00 mg / 10.00 mg / 20.00 mg / 30.00 mg / 40.00 mg, butylhydroxyanisole 0.01 mg / 0.02 mg / 0.04 mg / 0.06 mg / 0.08 mg, ascorbic acid 1.30 mg / 2 , 50 mg / 5.00 mg / 7.50 mg / 10.00 mg, citric acid monohydrate 0.63 mg / 1.30 mg / 2.50 mg / 3.80 mg / 5.00 mg, magnesium stearate 0 50 mg / 1.00 mg / 2.00 mg / 3.00 mg / 4.00 mg
Lub plhaub: hypromellose-5 cps 0.35 mg / 0.70 mg / 1.50 mg / 2.00 mg / 3.00 mg, hypromellose-15 cps 0.53 mg / 1.10 mg / 2.30 mg / 3.00 mg / 4.50 mg, talc 0.16 mg / 0.32 mg / 0.69 mg / 0.90 mg / 1.40 mg, titanium dioxide (E171) 0.40 mg / 0.80 mg / 1.70 mg / 2.30 mg / 3.4 mg, daj xim hlau oxide zas 0.0043 mg / 0.0017 mg / 0.11 mg / - / -, muaj xim hlau liab liab / - 0.0043 mg / 0.026 mg / - / 0.14 mg.

Kev piav qhia

Oval, ntsiav tshuaj biconvex, zaj duab xis-txheej, nrog ib qho nqis siab ntawm ib sab thiab tus txaug rau sab nraud, nrog ob sab kev pheej hmoo. Tus ntoo khaub lig yog dawb.
Dosage 5 mg: ntsiav tshuaj ntawm lub teeb daj xim nrog engraving "SIM 5".

Dosage 10 mg: ntsiav tshuaj ntawm lub teeb liab xim nrog engraving "SIM 10".
Dosage 20 mg: ntsiav tshuaj ntawm lub teeb txiv kab ntxwv xim nrog engraving "SIM 20".
Dosage 30 mg: Ntsiav tshuaj dawb los yog yuav luag xim dawb nrog engraving "SIM 30".

Dosage 40 mg: ntsiav tshuaj liab ntsiav nrog engraving "SIM 40".