AUGMENTIN 625 - cov lus qhia rau kev siv, nqe, tshuaj xyuas thiab analogues

Thov, ua ntej yuav Augmentin, ntsiav tshuaj 625 mg, 14 pcs., Txheeb xyuas cov ntaub ntawv hais txog nws nrog cov ntaub ntawv ntawm lub vev xaib raug cai ntawm cov chaw tsim khoom lossis hais kom meej cov qauv tshwj xeeb nrog tus thawj tswj haujlwm ntawm peb lub tuam txhab!

Cov ntaub ntawv qhia ntawm lub xaib tsis yog pej xeem kev pom zoo. Lub chaw tsim khoom muaj txoj cai los hloov cov qauv tsim, tsim qauv thiab ntim khoom. Cov duab ntawm cov khoom hauv cov duab tau tshaj tawm hauv phau ntawv teev npe ntawm lub xaib yuav txawv ntawm cov qauv.

Cov ntaub ntawv ntawm tus nqi ntawm cov khoom tau hais hauv phau ntawv qhia rau ntawm lub xaib yuav txawv qhov tseeb ntawm ib tus neeg thaum lub sijhawm tso daim ntawv txiav txim rau cov khoom lag luam.

Chaw tsim tshuaj paus

Cov khoom xyaw nquag: amoxicillin (hauv daim ntawv ntawm trihydrate) - 875 mg, clavulanic acid (hauv daim ntawv ntawm cov ntsev potassium) - 125 mg.

Cov zam: magnesium stearate - 14.5 mg, sodium carboxymethyl hmoov txhuv nplej siab - 29 mg, colloidal silicon dioxide - 10 mg, microcrystalline cellulose - 396,5 mg.

Cov kev sib xyaw ntawm cov zaj duab xis membrane: titanium dioxide - 13.76 mg, hypromellose (5 cps) - 10.56 mg, hypromellose (15 cps) - 3.52 mg, macrogol 4000 - 2.08 mg, macrogol 6000 - 2.08 mg, dimethicone - 0.013 mg.

Pharmacological kev txiav txim

Augmentin yog ntau yam-tua kabmob, tua kabmob.

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv mus rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid beta-lactamases, uas feem ntau lub luag haujlwm tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv cov chromosomal beta-lactamases ntawm hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob hauv Augmentin ® kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.

Cov hauv qab no yog hauv kev ua haujlwm hauv vitro ntawm amoxicillin nrog clavulanic acid.

Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus spp., Incl. Tus kab mob Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2 (lwm beta hemolytic streptococci) 1,2, Staphylococcus aureus (nkag siab rau methicillin) 1, Staphylococcus saprophyticus (nkag siab rau methicillin), coagulase-negative staphylococci.

Gram-positive anaerobes: Clostridium spp., Peptococcus niger, Peptostreptococcus spp., Suav nrog Peptostreptococcus magnus, Peptostreptococcus micros.

Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Gram-negative anaerobes: Bacteroides spp., Ua Pob. Bacteroides fragilis, Capnocytophaga spp., Eikenella corrodens, Fusobacterium spp., Xws li Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim

Nyiaj Gram-negative aerobes: Escherichia coli 1, Klebsiella spp., Incl. Klebsiella oxytoca, Klebsiella pneumoniae 1, Proteus spp., Xws li Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Gram-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2, streptococcus pawg Viridans.

Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid

Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia.

Lwm yam: Chlamydia spp., Incl. Chlamydia mob ntsws, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Rau cov kab mob no, kev kho mob ua tau zoo ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid tau ua kom pom hauv kev tshawb fawb soj ntsuam.

2 Hom kab ntawm cov kab mob no tsis tsim cov tshuaj beta-lactamase. Kev nkag siab nrog amoxicillin monotherapy qhia qhov zoo sib xws mus rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Ob lub cev sib xyaw ntawm Augmentin ® kev npaj - amoxicillin thiab clavulanic acid - tau sai thiab tag nrho los ntawm txoj hnyuv plab tom qab kev tswj hwm qhov ncauj. Qhov nqus ntawm cov khoom xyaw nquag ntawm cov tshuaj Augmentin ® yog qhov zoo dua rau thaum muaj kev noj tshuaj thaum pib noj mov.

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob siv 40 mg + 10 mg / kg / hnub ntawm Augmentin ® hauv peb koob tshuaj, hmoov rau lub qhov ncauj ncua, 125 mg + 31.25 mg hauv 5 ml (156.25 mg).

Kev sib xyaw ntawm amoxicillin nrog clavulanic acid yog qhia rau kev kho mob ntawm cov kab mob ntawm cov chaw hauv qab no tshwm sim los ntawm cov kab mob me me nkag siab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid:

• cov kab mob ua pa sab saud (suav nrog rau mob ENT), xws li ua mob tonsillitis, mob ntsws, mob otitis media, feem ntau yog los ntawm Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 thiab Streptococcus pyogenes, (tshwj tsis yog Augmentin 250 mg / 125 mg ntsiav tshuaj),
• cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, lobar mob ntsws thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae 1 thiab Moraxella catarrhalis 1,
• mob txeeb zig, piv txwv li, cystitis, urethritis, pyelonephritis, poj niam qhov chaw mos, feem ntau yog tshwm sim los ntawm hom kab mob Enterobacteriaceae 1 tsev neeg (feem ntau Escherichia coli 1), Staphylococcus saprophyticus thiab Enterococcus, nrog rau tus kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae 1,
• kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus 1, Streptococcus pyogenes thiab hom kab mob ntawm cov genus Bacteroides 1,
• kis kab mob ntawm cov pob txha thiab pob qij txha, piv txwv osteomyelitis, feem ntau tshwm sim los ntawm Staphylococcus aureus 1, yog tias tsim nyog, kev kho mob ntev yog ua tau.
• cov kab mob odontogenic, piv txwv li kab mob txha caj qaum, odontogenic maxillary sinusitis, mob hniav ntau heev nrog kev kis mob cellulitis (tsuas yog rau cov ntsiav tshuaj Augmentin cov ntawv, ntau npaum li 500 mg / 125 mg, 875 mg / 125 mg),
• lwm cov kab mob sib xyaw (piv txwv, septic rho menyuam, tom qab sepsis, mob intraabdominal sepsis) yog ib feem ntawm kev kho mob kauj ruam (tsuas yog rau cov ntsiav tshuaj Augmentin ntau npaum 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

Cev xeeb tub thiab lactation

Hauv kev tshawb fawb ntawm kev ua me nyuam hauv cov tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin® tsis ua rau muaj teebmeem teratogenic.

Hauv kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev xoos xoos, nws tau pom tias prophylactic kev siv tshuaj kho mob yuav cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos. Zoo li txhua yam tshuaj, Augmentin® tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias muaj kev cia siab rau tus niam tshaj qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Cov tshuaj Augmentin® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab lossis ua paug rau ntawm cov kua qog ua rau lub qhov ncauj ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov tshuaj yeeb dej caw ntawm cov tshuaj no mus rau niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos niam mis. Thaum muaj qhov tshwm sim tsis zoo hauv cov menyuam yaus noj niam mis, kev pub mis niam yuav tsum tsis tsum.

Sab sij huam

Kis thiab cov kab mob cab: feem ntau - candidiasis ntawm daim tawv nqaij thiab mucous daim nyias nyias.

Ntawm ib feem ntawm cov ntshav thiab cov lymphatic system: tsis tshua muaj, thim rov qab leukopenia (suav nrog neutropenia) thiab thim rov qab thrombocytopenia, tsis tshua muaj mob, thim rov qab agranulocytosis thiab thim rov qab hemolytic anemia, ua ntev ntawm prothrombin lub sijhawm thiab lub sijhawm los ntshav, ntshav tsis txaus, eosinophilia, thrombocytosis.

Los ntawm lub nruab zog: tsis tshua muaj tshwm sim - angioedema, kev phiv tshuaj anaphylactic, tus mob zoo ib yam li kev mob ntshav dej, tshuaj mob vasculitis.

Los ntawm lub paj hlwb: tso tsis tau - kiv taub hau, mob taub hau, tsis tshua muaj tshwm sim - thim rov qab hyperactivity, convulsions (txiav tau tuaj yeem tshwm sim rau cov neeg mob uas lub raum tsis ua haujlwm, zoo li hauv cov neeg uas tau txais cov tshuaj ntau heev), insomnia, ntxhov siab, ntxhov siab, hloov tus cwj pwm.

Los ntawm cov hnyuv: cov neeg laus: heev - raws plab, nquag - xeev siab, ntuav, menyuam yaus - feem ntau - raws plab, xeev ntuav, ntuav, tag nrho cov pejxeem: xeev siab yog feem ntau pom thaum siv tshuaj ntau kawg. Yog tias tom qab pib noj cov tshuaj muaj qhov tsis tsim nyog tshwm sim los ntawm txoj hnyuv, lawv tuaj yeem tshem tawm yog tias koj noj cov tshuaj thaum pib noj mov. Cuam tshuam - lub plab zom mov, tsis tshua muaj tshwm sim - cov tshuaj tua kab mob ntsig txog kev mob plab los ntawm kev siv tshuaj tua kab mob (suav nrog rau cov mob ua paug thiab cov mob plab), dub nplaig "muaj nplaig", mob plab, mob plab. Hauv cov menyuam yaus, thaum ua ntawv thov kev ncua, qhov cuam tshuam ntawm txheej txheej txheej hniav txha hniav laus yog qhov tsis tshua pom muaj. Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob muaj qhov sib txawv ntawm tus hniav txha hniav laus, vim nws txaus los txhuam koj cov hniav.

Nyob rau ib feem ntawm daim siab thiab kais plab: tsis nkag siab - qhov nruab nrab nce siab ntawm ACT thiab / lossis kev ua haujlwm ALT (pom nyob rau hauv cov neeg mob tau txais beta-lactam tshuaj tua kab mob, tab sis nws qhov tseem ceeb hauv chav kho mob tsis paub), muaj tsawg kawg ntawm kev mob siab thiab mob cholestatic jaundice (cov tshwm sim no tau sau tseg thaum kho nrog lwm yam penicillins thiab cephalosporins), kev nce siab ntawm bilirubin. thiab phosphatase alkaline. Kev phiv tshuaj los ntawm daim siab raug pom muaj feem ntau hauv cov txiv neej thiab cov neeg laus laus thiab yuav cuam tshuam nrog kev kho lub sij hawm ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus.

Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, txawm li cas los xij qee zaum qee zaum lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg muaj mob loj los sib deev lossis cov neeg tau txais cov tshuaj muaj kabmob hepatotoxic tib lub sijhawm

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: tsis ncaw - pob khaus, pruritus, urticaria, tsis tshua muaj erythema multiforme, tsis tshua muaj Stevens-Johnson syndrome, muaj mob ua paug rau cov leeg ntshav, ua kom tawv nqaij mob dermatitis, ua kom tus mob ua paug rau tus kab mob pustulosis.

Yog tias muaj tawv nqaij tsis haum, kev kho nrog Augmentin® yuav tsum tsis ua mus ntxiv.

Los ntawm ob lub raum thiab mob txeeb zig: tsis tshua muaj tshwm sim - interstitial nephritis, crystalluria, hematuria.

Kev sib txuam

Kev siv ua ke ib txhij ntawm cov tshuaj Augmentin® thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin® thiab probenecide tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid.

Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol. Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li ntawd, tib lub sijhawm siv Augmentin® thiab methotrexate tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate.

Zoo li lwm yam tshuaj tua kab mob, Augmentin® tuaj yeem cuam tshuam rau lub plab hnyuv microflora, ua rau txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua tau zoo ntawm kev sib xyaw ua ke ntawm lub qhov ncauj.

Cov ntawv nyeem tau piav qhia qhov tsis tshua muaj qhov tshwm sim ntawm kev nce qib hauv kev thoob ntiaj teb (MHO) hauv cov neeg mob uas siv cov acenocoumarol lossis warfarin thiab amoxicillin. Yog tias tsim nyog, kev tswj hwm tib lub sijhawm ntawm Augmentin® npaj nrog anticoagulants, lub sijhawm prothrombin lossis MHO yuav tsum ua tib zoo saib xyuas thaum sau ntawv lossis tsum tsis npaj rau Augmentin; kev npaj kho;

Yuav ua li cas coj, chav kawm ntawm kev tswj hwm thiab ntau npaum li cas

Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.

Txhawm rau kom zoo thiab txo qis kev phiv los ntawm lub plab zom mov, Augmentin® pom zoo kom noj thaum pib noj mov.

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua

1 ntsiav tshuaj ntawm 250 mg / 125 mg 3 zaug / hnub (rau kev kis mob me txog rau mob hnyav), lossis 1 ntsiav tshuaj ntawm 500 mg / 125 mg 3 zaug / hnub, lossis 1 ntsiav tshuaj ntawm 875 mg / 125 mg 2 zaug / hnub, lossis 11 ml ntawm kev ncua ntawm 400 mg / 57 mg / 5 ml 2 zaug / hnub (uas yog sib npaug rau 1 ntsiav tshuaj ntawm 875 mg / 125 mg).

2 ntsiav tshuaj ntawm 250 mg / 125 mg tsis sib npaug rau 1 ntsiav tshuaj ntawm 500 mg / 125 mg.

Cov menyuam yaus hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua 40 kg

Cov tshuaj yog sau tseg hauv daim ntawv ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj.

Kev suav qhov ntsuas yog ua raws li hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg lub cev qhov hnyav / hnub (xam raws li amoxicillin) lossis hauv ml ntawm kev ncua.

Qhov ntau yam pauv ntawm qhov kev ncua 125 mg / 31.25 mg hauv 5 ml - 3 zaug / hnub txhua 8 teev

Qhov ntau yam ntawm kev ncua 200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml - 2 zaug / hnub txhua 12 teev.

Cov kev xav noj ntau npaum li cas thiab kev tswj hwm pes tsawg yog hais hauv qab no:

Kev ntau dua ntawm kev nkag mus - 3 zaug / hnub, ncua 4: 1 (125 mg / 31.25 mg hauv 5 ml):

• Tsawg koob tshuaj - 20 mg / kg / hnub.
• Kev txhaj tshuaj ntau - 40 mg / kg / hnub.

Kev ntau ntau ntawm kev tswj hwm - 2 zaug / hnub, kev ncua 7: 1 (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml):

• Kev txhaj tshuaj qis - 25 mg / kg / hnub.
• Kev txhaj tshuaj ntau - 45 mg / kg / hnub.

Kev txhaj tshuaj qis ntawm Augmentin® yog siv los kho cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau cov mob tonsillitis.

Kev txhaj tshuaj ntau ntawm Augmentin® yog siv los kho cov kab mob xws li otitis media, sinusitis, mob kis qis dua ntawm txoj hlab ntsws thiab mob txeeb zig, kis kab mob ntawm cov pob txha thiab pob qij txha.

Muaj cov ntaub ntawv kuaj mob tsis txaus kom pom zoo siv cov tshuaj Augmentin® ntawm koob tshuaj ntau dua 40 mg / kg / hnub hauv 3 koob tshuaj (4: 1 ncua kev kawm) hauv cov menyuam yaus hnub nyoog qis dua 2 xyoos.

Cov menyuam txij thaum yug mus txog 3 hlis

Vim lub cev tsis muaj nuj nqi ntawm qhov muaj nuj nqi zoo kawg ntawm lub raum, qhov tshuaj pom zoo ntawm Augmentin® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.

Kev siv qhov kev ncua 7: 1 (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml) tsis pom zoo rau cov neeg no.

Cov menyuam yug ua ntej

Tsis muaj cov lus qhia hais txog qhov muab tshuaj.

Cov neeg laus cov neeg mob

Tsis tas yuav txhaj ib koob. Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, qhov koob tshuaj yuav tsum tau kho raws li cov lus qhia rau cov neeg laus uas lub raum tsis ua haujlwm.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug kwv yees QC cov txiaj ntsig.

Ntsiav tshuaj 250 mg + 125 mg lossis 500 mg + 500 mg:

• KK> 30 ml / min - kev kho ntawm kev muab tshuaj yog tsis tas yuav tsum tau ua.
• KK 10-30 ml / min - 1 tab. 250 mg + 125 mg 2 zaug / hnub lossis 1 tab. 500 mg + 125 mg (rau kev sib kis mob me txog rau mob) 2 zaug / hnub.
• QC

Ncua Sijhawm 4: 1 (125 mg / 31.25 mg hauv 5 ml):

• KK> 30 ml / min - kev kho ntawm kev muab tshuaj yog tsis tas yuav tsum tau ua.
• KK 10-30 ml / min - 15 mg / 3.75 mg / kg 2 zaug / hnub, qhov ntau tshaj yog 500 mg / 125 mg 2 zaug / hnub.
• QC

875 mg + 125 mg ntsiav tshuaj thiab 7: 1 ncua kev kawm (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml) yuav tsum tsuas yog siv rau cov neeg mob CC> 30 ml / min, uas tsis muaj kev kho qhov tshuaj yuav tsum tau.

Feem ntau, yog tias ua tau, kev kho mob rau cov niam txiv yuav tsum yog qhov zoo dua.

Cov neeg mob Hemodialysis

Kev hloov pauv koob tshuaj yog ua raws li qhov siab tshaj plaws ntawm kev tso cai ntawm amoxicillin: 2 tab. 250 mg / 125 mg hauv ib koob tshuaj txhua 24 teev, lossis 1 daim pib. 500 mg / 125 mg nyob rau hauv ib koob txhua 24 teev, lossis ncua kev ncua ntawm 15 mg / 3.75 mg / kg 1 zaug / hnub.

Ntsiav tshuaj: thaum lub caij ntu mob hemodialysis, ib qho ntxiv 1 koob tshuaj (ib ntsiav tshuaj) thiab 1 koob tshuaj ntxiv (ib ntsiav tshuaj) tom qab kawg ntawm kev lim ntshav (kom them rau qhov txo qis hauv cov ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Raug tshem tawm: ua ntej kev kho mob hemodialysis, ib koob tshuaj ntxiv ntawm 15 mg / 3.75 mg / kg yuav tsum tau muab tshuaj. Txhawm rau kom rov qab ua dua qhov kev coj ua ntawm cov tshuaj nquag Augmentin® hauv cov ntshav, ntxiv ib koob thib ob ntawm 15 mg / 3.75 mg / kg yuav tsum tau qhia tom qab kev sib tham ntawm hemodialysis.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los kho qhov tshuaj ntau npaum li cas hauv pawg neeg mob no.

Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawv

Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug.

Ncua (125 mg / 31.25 mg hauv 5 ml): kwv yees li 60 ml ntawm cov dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, ua kom lub raj mis sawv ntsug li 5 feeb rau ua kom tiav kev sib tua. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 92 ml ntawm dej yog xav tau los npaj qhov kev ncua. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov raug ncua ntawm kev npaj Augmentin® tuaj yeem nchuav ib nrab nrog dej.

Ncua (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml): ntxiv kwv yees li 40 ml ntawm dej rhaub kom txias mus rau chav tsev kub mus rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis taub hau thiab co kom txog thaum cov hmoov yaj tag. Tso kom vial sawv ntsug li 5 feeb kom paub meej kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 64 ml ntawm dej yog xav tau los npaj qhov kev ncua. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug qhov tseeb ntawm cov tshuaj, siv lub hau ntsuas lossis cov koob txhaj tshuaj, uas yuav tsum tau ntxuav nrog dej zoo tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov ncua kev ncua ntawm Augmentin® kev npaj yuav tuaj yeem xeb nrog dej hauv qhov sib piv ntawm 1: 1.

Noj ntau dhau

Cov tsos mob: lub plab zom mov cov tsos mob thiab dej-electrolyte tsis txaus yuav tshwm sim. Amoxicillin crystalluria tau piav qhia, hauv qee kis ua rau kev loj hlob ntawm lub raum tsis ua haujlwm.

Qhov ncauj keev tuaj yeem tshwm sim rau cov neeg mob uas lub raum lub raum tsis ua haujlwm, nrog rau cov neeg uas tau txais tshuaj ntau heev.

Kev Kho Mob: mob plab zom mov - kev kho mob kom zoo, them nyiaj tshwj xeeb rau kev ua kom dej-electrolyte sib npaug. Yog tias muaj kev noj ntau dhau, amoxicillin thiab clavulanic acid tuaj yeem tshem tawm cov ntshav tawm los ntawm hemodialysis.

Cov txiaj ntsig ntawm kev soj ntsuam ib txwm muaj nrog 51 tus menyuam ntawm lub chaw tso tshuaj lom tau qhia tias kev tswj hwm ntawm amoxicillin ntawm koob tshuaj tsawg dua 250 mg / kg tsis tau ua rau cov tsos mob tseem ceeb thiab tsis tas yuav ua kom mob plab.

Cov lus qhia tshwj xeeb

Ua ntej pib kho nrog Augmentin®, nws yog ib qho tsim nyog yuav tsum tau sau cov ncauj lus kom ntxaws txog kev kho mob yav dhau los ntsig txog kev tiv thaiv kab mob siab rau penicillins, cephalosporins lossis lwm yam kev ua xua.

Cov mob hnyav, thiab qee zaum kuj ua rau neeg tuag taus, ua kom lub cev tsis haum tshuaj (qhov tsis haum tshuaj muaj txiaj ntsig) rau cov penicillins tau piav qhia. Txoj kev pheej hmoo ntawm cov kev tawm tsam zoo li no yog qhov siab tshaj plaws rau cov neeg mob uas muaj keeb kwm ntawm kev tsis haum lub cev rau penicillins. Thaum muaj kev fab tshuaj tsis haum, nws yog ib qho tsim nyog yuav tsum tsis mus kho nrog Augmentin® thiab pib kho lwm txoj kev kho kom haum. Yog tias muaj teeb meem rau qhov mob nyhav dhau los, yuav tsum muab tshuaj rau epinephrine sai sai. Kev kho cov pa oxygen, kev tswj hwm kev tswj hwm ntawm GCS thiab kev pabcuam hauv airway patency, suav nrog kev nkag mus ntxiv, kuj tseem yuav tsum ua.

Kev teem sijhawm rau cov tshuaj Augmentin® tsis pom zoo rau cov neeg xav tias muaj tus mob mononukpeosis, vim tias nyob hauv cov neeg mob tus mob amoxicillin tuaj yeem ua rau mob pob khaus zoo li pob khaus, uas ua rau muaj kev cuam tshuam ntau ntawm kev kuaj mob.

Kev kho mob mus ntev nrog Augmentin® qee zaum ua rau muaj kev tawm tsam ntau ntawm cov kab mob tsis haum.

Hauv qhov dav dav, Augmentin tole tau pom zoo zoo thiab muaj cov tshuaj toxicity qis ntawm txhua tus penicillins.

Lub sijhawm kho mob ntev nrog Augmentin®, nws raug nquahu kom ntsuas qee lub sijhawm ua haujlwm ntawm lub raum, mob siab thiab ntshav.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj thaum noj mov.

Hauv cov neeg mob uas tau txais kev sib xyaw ntawm amoxicillin nrog clavulanic acid ua ke nrog indirect (qhov ncauj) anticoagulants, nyob rau hauv cov xwm txheej tsis tshua muaj, kev nce prothrombin lub sijhawm (nce hauv MHO) tau tshaj tawm. Nrog rau kev sib koom tes ntawm kev tiv thaiv kabmob (qhov ncauj) anticoagulants nrog kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev saib xyuas ntawm cov ntsuas tseem ceeb yog qhov tsim nyog. Yuav kom tswj tau qhov xav tau ntawm qhov ncauj ua kom lub ntsej muag, qhov ntau npaum yuav tsum tau hloov kho.

Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov tshuaj ntawm Augmentin® yuav tsum tau txo kom haum raws li qhov ntsuas ntawm qhov tsis taus.

Hauv cov neeg mob uas txo qis diuresis, feem ntau tsis tshua muaj, kev loj hlob ntawm crystalluria tau tshaj tawm, feem ntau nrog kev siv tshuaj yaj yeeb. Thaum lub sijhawm tswj hwm ntawm amoxicillin koob tshuaj ntau, nws raug nquahu kom noj cov kua txaus thiab tswj cov diuresis kom txaus los txo qhov muaj feem ntawm kev tsim cov amoxicillin muaju.

Noj cov tshuaj Augmentin® sab hauv ua rau cov ntsiab lus ntawm amoxicillin nyob rau hauv cov zis, uas tuaj yeem ua rau cov lus tsis muaj qhov tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis (piv txwv, kev kuaj Benedict, ib qho kev sim Feling). Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis.

Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob ua kom pom cov hniav, txij li txhuam koj cov hniav tau txaus.

Cov ntsiav tshuaj yuav tsum tau siv tsis pub dhau 30 hnub txij li lub sijhawm qhib pob ntawm laminated lev ntawv ci.

Kev quav yeeb quav tshuaj thiab quav yeeb tshuaj

Tsis pom muaj kev quav yeeb tshuaj, quav tshuaj thiab kev tsis haum tshuaj cuam tshuam nrog kev siv tshuaj Augmentin® tau pom.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Txij li thaum cov tshuaj yuav ua rau kiv taub hau, nws yog ib qho tsim nyog ceeb toom rau cov neeg mob txog kev ceev faj thaum tsav tsheb lossis ua haujlwm nrog cov tshuab txav.

Yuav siv cov tshuaj Augmentin 625 li cas?

Semi-hluav taws xob tshuaj tua kab mob ntawm penicillin pawg ntawm kev ua ntau Augmentin 625 yog siv los kho cov txheej txheem mob hauv lub cev.Cov mob los ntawm cov kab mob me me uas nkag rau amoxicillin teb rau kev kho mob. Cov tshuaj yog siv los rhuav tshem cov ntawv sib xyaw uas muaj los ntawm cov kab mob thiab cov microbes. Qee cov kab mob muaj me tub lactamases, tsim tshuaj tiv thaiv kab mob. Amoxicillin txuam nrog clavulanic acid txo lawv qhov kev tawm tsam.

Beta-lactams yog cov tshuaj tiv thaiv kabmob rau kev siv systemic thiab yog kev sib txuas ntawm beta-lactamase kev rhuav tshem thiab penicillins. Cov cai J01C R02.

Semi-hluav taws xob tshuaj tua kab mob ntawm penicillin pawg ntawm kev ua ntau Augmentin 625 yog siv los kho cov txheej txheem mob hauv lub cev.

Tso cov ntaub ntawv thiab cov nyob ua ke

Cov tshuaj hauv qhov ntau npaum ntawm 650 (500 mg + 125 mg) muaj nyob hauv daim ntawv dawb lossis nrog qhov ntxoov ntxoo me me ntawm cov ntsiav tshuaj hauv daim ntawv ntawm oval. Ntawm lub plhaub yog cov ntawv sau AC, ntawm ib sab yog nqis siab tshaj. 7 daim ntim rau hauv ntawv ci, uas yog 2 ntim rau hauv ib lub thawv ntawv. Cov hmoov hauv lub vial tsis muaj yog ib qho kev tshem tawm.

• amoxicillin yog nthuav tawm ua trihydrate, nws muaj 500 mg,
• clavulanate ua ke nyob rau hauv ib qho nyiaj ntawm 125 mg.

Cov Tshuaj Pharmacokinetics

Ob lub ntsiab yog tus tshaj tawm adsorbed thaum noj qhov ncauj, lawv cov kev noj qab nyob zoo nyob rau qib 70%. Lub sijhawm nthuav tawm ntawm cov ntsiab lus siab tshaj plaws hauv cov ntshav ntshav yog 1 teev. Lub plasma concentration thaum siv kev sib xyaw ua ke ntawm kev sib xyaw ntawm Augmentin yog qhov zoo sib xws, zoo li yog noj amoxicillin thiab clavulanate cais.

Ib quarter ntawm tag nrho cov nyiaj clavulanate cuam tshuam nrog cov protein, amoxicillin khi ntawm 18%. Hauv lub cev, cov tshuaj yeeb dej caw tau faib raws li:

• agntibiotic - 0.31 - 0.41 L ib phaus ntawm lub cev hnyav,
• acid - 0.21 l ib kilogram ntawm pawg.

Tom qab kev tswj hwm, ob qho sib xyaw ua haujlwm tau tshawb pom nyob rau ntawm peritoneum, roj txheej, lub zais zis, lub plab, cov leeg, ascites thiab cov kua dej txhaws. Amoxicillin yuav luag tsis pom muaj nyob rau hauv cov kua dej cerebrospinal, tab sis nkag mus hauv tus poj niam cov kua mis thiab los ntawm cov placenta. Hauv lub cev cov ntaub so ntswg, cov tshuaj yeeb dej caw thiab cov khoom coj los ua ke tsis txuam nrog.

Amoxicillin tawm nyob rau hauv daim ntawv ntawm ricinoleic acid nyob rau hauv ib lub ntim ntawm ib hlis twg ntawm kev pib siv tshuaj tiv thaiv kab mob tso zis. Clavulanate yog 75-85% metabolized hauv lub cev thiab tawm hauv lub cev nrog cov quav, tso zis, tso tawm ntawm lub ntsws nrog cua mus rau hauv cov pa roj carbon dioxide.

Kev ntsuas rau siv

Cov tshuaj yog siv rau kev kho mob cuam tshuam rau cov neeg sawv cev nkag siab los ntawm Augmentin. Cov tshuaj yog siv los kho:

• qhov txhab ntawm cov tawv nqaij ntawm cov ntshav, mob tshwm sim tom qab mob khaub thuas, los ntswg, ntsej muag raug mob,
• o nyob rau hauv nruab nrab pob ntseg
• mob ua mob ntsws ntev ntev,
• mob ntsws loj hlob sab nraum lub tsev kho mob,
• o ntawm phab ntsa ntawm lub zais zis,
• qhov chaw mob ntawm tubule system hauv ob lub raum,
• kev kis mob ntawm cov leeg, cov nqaij thiab cov tawv nqaij tom qab yoov ntawm ntau yam tsiaj,
• kev puas tsuaj rau cov ntaub so ntswg thiab cov qauv hauv ib ncig ntawm cov hniav,
• pob txha thiab pob txha sib kis.

Cov ntsiav tshuaj, zaj duab xis-coated ntawm dawb mus rau yuav luag dawb, yog oval, nrog cov ntawv sau “AUGMENTIN” nias ntawm ib sab, ntawm qhov tawg, txij ntawm daj-dawb mus rau yuav luag dawb.

10 Pcs - hlwv (1) nrog ib lub hnab ntim ntawm silica gel - ntim ua los ntawm cov ntawv ci txhuas laminated (2) - pob ntawv los ntawm cardboard.

Cov ntsiav tshuaj, zaj duab xis-txheej los ntawm dawb mus rau yuav luag dawb, yog oval, nrog extruded inscription "AC" thiab qhov pheej hmoo ntawm ib sab.

Cov neeg siv tshwj xeeb: magnesium stearate - 7.27 mg, sodium carboxymethyl hmoov txhuv nplej siab - 21 mg, colloidal silicon dioxide - 10.5 mg, microcrystalline cellulose - txog 1050 mg.

7 Pcs - hlwv (1) nrog ib lub hnab ntim ntawm silica gel - ntim ua los ntawm cov ntawv ci txhuas laminated (2) - pob ntawv los ntawm cardboard.
10 Pcs - hlwv (1) nrog ib lub hnab ntim ntawm silica gel - ntim ua los ntawm cov ntawv ci txhuas laminated (2) - pob ntawv los ntawm cardboard.

Cov ntsiav tshuaj, zaj duab xis-dawb los ntawm dawb rau yuav luag dawb, yog oval, nrog cov tsiaj ntawv "A" thiab "C" ntawm ob sab ntawm lub ntsiav tshuaj thiab cov kab ua txhaum ntawm ib sab, ntawm pob txha lov - los ntawm daj dawb mus rau yuav luag dawb.

Cov zam: magnesium stearate - 14.5 mg, sodium carboxymethyl hmoov txhuv nplej siab - 29 mg, colloidal silicon dioxide - 10 mg, microcrystalline cellulose - 396.5 mg.

7 Pcs - hlwv (1) nrog ib lub hnab ntim ntawm silica gel - ntim ua los ntawm cov ntawv ci txhuas laminated (2) - pob ntawv los ntawm cardboard.

Hmoov rau qhov kev npaj tawm ntawm kev ncua rau qhov ncauj kev tswj hwm ntawm cov xim dawb lossis yuav luag dawb, nrog tus yam ntxwv tsis hnov ​​tsw, thaum diluted, ncua kev ncua lossis dawb yuav luag tsim, thaum sawv, dej nag lossis daus dawb yuav luag tsim maj mam.

11,5 g - iav fwj (1) ua tiav nrog lub hau ntsuas - pob khoom ntawm duab los qhia.

Hmoov rau qhov kev npaj tawm ntawm kev ncua rau qhov ncauj kev tswj hwm ntawm cov xim dawb lossis yuav luag dawb, nrog tus yam ntxwv tsis hnov ​​tsw, thaum diluted, ncua kev ncua lossis dawb yuav luag tsim, thaum sawv, dej nag lossis daus dawb yuav luag tsim maj mam.

7.7 g - iav fwj (1) ua tiav nrog lub hau ntsuas - pob khoom ntawm duab los qhia.

Hmoov rau qhov kev npaj tawm ntawm kev ncua rau qhov ncauj kev tswj hwm ntawm cov xim dawb lossis yuav luag dawb, nrog tus yam ntxwv tsis hnov ​​tsw, thaum diluted, ncua kev ncua lossis dawb yuav luag tsim, thaum sawv, dej nag lossis daus dawb yuav luag tsim maj mam.

12.6 g - iav fwj (1) ua tiav nrog lub hau ntsuas - pob khoom ntawm duab los qhia.

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Nyob rau tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm β-lactamases, thiab yog li ntawd kev ua si spectrum ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, ib qho β-lactamase inhibitor yam ntxwv ntawm kev siv rau penicillins, muaj peev xwm tsis muaj peev xwm tiv thaiv ntau yam ntawm β-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin resistant microorganisms.

Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid β-lactamases, uas feem ntau ua rau cov kab mob tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv chromosomal β-lactamases ntawm hom 1 uas tsis tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob hauv kev npaj Augmentin tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - act-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.

Cov hauv qab no yog hauv kev ua haujlwm hauv vitro ntawm amoxicillin nrog clavulanic acid.

Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus pyogenes 1,2, Streptococcus agalactiae 1,2, Streptococcus spp. (lwm beta hemolytic streptococci) 1,2, Staphylococcus aureus (nkag siab rau methicillin) 1, Staphylococcus saprophyticus (rhiab rau methicillin), Staphylococcus spp. (coagulase-negative, rhiab rau methicillin).

Gram-negative aerobes: Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Gram-positive anaerobes: Clostridium spp., Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp.

Gram-negative anaerobes: Bacteroides fragilis, Bacteroides spp., Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella spp.

Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim

Gram-negative aerobes: Escherichia coli 1, Klebsiella oxytoca, Klebsiella pneumoniae 1, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.

Gram-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2, Streptococcus pawg Viridans 2.

Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid

Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia.

Lwm yam: Chlamydia mob ntsws, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

1 - rau cov kab mob sib kis, kev soj ntsuam kev ua tau zoo ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid tau pom nyob hauv kev tshawb fawb.

2 - hom kab mob ntawm cov hom kab no tsis tsim β-lactamases. Kev nkag siab nrog amoxicillin monotherapy qhia qhov zoo sib xws mus rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Ob lub cev ua ke ntawm cov tshuaj Augmentin, amoxicillin thiab clavulanic acid, tau nrawm thiab nrawm los ntawm lub plab zom mov tom qab kev tswj hwm qhov ncauj. Qhov nqus ntawm cov tshuaj nquag yog qhov zoo dua hauv kev noj tshuaj thaum pib noj mov.

Ntsiav tshuaj Augmentin 250 mg / 125 mg (375 mg), Augmentin 250 mg / 125 mg (375 mg), Augmentin 500 mg / 125 mg (625 mg), Augmentin 875 mg / 125 mg (1000 mg)

Cov chaw muag tshuaj ntawm amoxicillin thiab clavulanic acid, tau txais hauv cov kev tshawb fawb sib txawv, thaum cov neeg tuaj yeem noj qab haus huv tau coj lub plab khoob, muaj li hauv qab no:

- 1 ntsiav tshuaj ntawm tshuaj Augmentin 250 mg / 125 mg (375 mg),

- 2 ntsiav tshuaj ntawm Tshuaj Augmentin 250 mg / 125 mg (375 mg),

- 1 ntsiav tshuaj ntawm tshuaj Augmentin 500 mg / 125 mg (625 mg),

- 500 mg ntawm amoxicillin,

- 125 mg ntawm clavulanic acid,

- 2 ntsiav tshuaj ntawm tshuaj Augmentin 875 mg / 125 mg (1000 mg)

Lub ntsiab pharmacokinetic tseem ceeb tau nthuav qhia hauv lub rooj.

Thaum siv Augmentin, ntshav ntau ntawm amoxicillin zoo ib yam rau kev coj noj ntawm amoxicillin hauv koob tshuaj sib npaug.

Augmentin 125 mg / 31.25 mg rau 5 ml qhov ncauj raug tshem tawm hmoov

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob tau 40 mg / 10 mg / kg lub cev hnyav / hnub ntawm cov tshuaj Augmentin, hmoov rau qhov ncauj tawm hauv 3 koob. 125 mg / 31.25 mg hauv 5 ml (156.25 mg).

Lub ntsiab pharmacokinetic tseem ceeb.

Hmoov rau kev ncua rau kev tswj hwm qhov ncauj Augmentin 200 mg / 28.5 mg hauv 5 ml

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo ntawm lub plab tsis muaj tshuaj noj cov tshuaj Augmentin, hmoov rau lub qhov ncauj ncua, 200 mg / 28.5 mg hauv 5 ml (228.5 mg) hauv koob tshuaj ntawm 45 mg / 6.4 mg / kg / hnub, muab faib ua ob zaug.

Yooj yim pharmacokinetic

Hmoov rau kev ncua rau kev tswj hwm qhov ncauj Augmentin 400 mg / 57 mg hauv 5 ml

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau txais hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg tuaj yeem noj qab haus huv tau noj ib zaug ntawm Augmentin, hmoov rau kev tshem tawm qhov ncauj, 400 mg / 57 mg hauv 5 ml (457 mg).

Yooj yim pharmacokinetic

Kev kho mob ntau ntawm amoxicillin thiab clavulanic acid yog tsim nyob rau hauv ntau yam plab hnyuv siab raum thiab cov ntaub so ntswg, cov kua dej interstitial (cov plab hnyuv plab hauv plab, adipose, pob txha thiab cov leeg nqaij, synovial thiab peritoneal kua, tawv nqaij, bile, purulent tawm).

Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tias 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin khi rau cov ntshav plasma protein.

Hauv kev tshawb nrhiav tsiaj, kev nruam ntawm cov khoom xyaw ntawm cov tshuaj Augmentin tsis pom.

Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Ib co kua nplaum ntawm clavulanic acid kuj tau pom nyob rau hauv niam mis. Cov kev tshawb fawb txog kev ua haujlwm ntawm kev ua me nyuam hauv tsiaj pom tias amoxicillin thiab clavulanic acid hla qhov chaw tiv thaiv kab mob, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.

10-25% ntawm thawj zaug koob tshuaj amoxicillin raug ntiab tawm los ntawm ob lub raum ua lub zog tsis haum (penicilloic acid). Clavulanic acid tau dav dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid thiab 1-amino-4-hydroxy-butan-2-ib thiab tau tawm los ntawm lub raum los ntawm kev zom cov pa zom zaws, ntxiv rau nrog cov huab cua tas sijhawm hauv daim ntawv carbon dioxide.

Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab.Cov kev tshawb fawb pom tau tias, thaj tsam li ntawm 60-70% ntawm amoxicillin thiab li 40-65% ntawm clavulanic acid raug tso tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab noj 1 ntsiav tshuaj ntawm 250 mg / 125 mg lossis 1 ntsiav tshuaj ntawm 500 mg / 125 mg.

Cov kab mob kis tau los ntawm cov tshuaj lom neeg lub cev:

Kev kis mob ntawm cov pa sab saud thiab cov kabmob ENT (xws li mob tonsillitis, mob ntsws, mob otitis media), feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogenes,

- cov kab mob ua pa tsawg dua: exacerbations ntawm mob ntsws ntev, lobar mob ntsws thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae * thiab Moraxella catarrhalis * (tshwj tsis yog rau ntsiav tshuaj 250 mg / 125 mg),

Kev kis tus mob Urogenital: cystitis, urethritis, pyelonephritis, kis mob rau poj niam lub cev, ua feem ntau los ntawm hom kab mob Enterobacteriaceae tsev neeg (feem ntau Escherichia coli *), Staphylococcus saprophyticus thiab hom kab mob ntawm genus Enterococcus,

- kab mob gonorrhea los ntawm Neisseria gonorrhoeae * (tshwj tsis yog ntsiav tshuaj 250 mg / 125 mg),

- kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus *, Streptococcus pyogenes thiab hom ntawm lub genus Bacteroides *,

- kis kab mob ntawm cov pob txha thiab pob qij txha: osteomyelitis, feem ntau tshwm sim los ntawm Staphylococcus aureus *, yog tias tsim nyog, kev kho mob ntev,

- cov kab mob hu ua odontogenic, piv txwv li, mob qog nqaij hlav, mob ntshav tawm tsam, mob hniav ntau nrog cov mob cellulite (rau cov ntsiav tshuaj 500 mg / 125 mg lossis 875 mg / 125 mg),

- lwm qhov sib xyaw sib xyaw (piv txwv, septic rho menyuam, sepsis tom qab, mob se rau lub plab) yog ib feem ntawm kev kho mob kauj ruam (rau cov ntsiav tshuaj 250 mg / 125 mg lossis 500 mg / 125 mg, lossis 875 mg / 125 mg).

* - Cov tib neeg sawv cev ntawm cov kab mob tshwj xeeb tsim tawm β-lactamase, uas ua rau lawv tsis muaj qhov tsis haum rau amoxicillin.

Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw. Augmentin tseem tau qhia rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me ua producing-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Qhov rhiab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av thiab dhau sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.

- Cov tshuaj tiv thaiv tsis haum rau amoxicillin, clavulanic acid, lwm yam tshuaj, tshuaj tua kab mob beta-lactam (piv txwv li penicillins, cephalosporins) hauv anamnesis,

- Cov xwm txheej daj ntseg yav dhau los lossis lub siab ua kom lub siab ua haujlwm thaum siv amoxicillin nrog clavulanic acid nyob rau hauv anamnesis,

- menyuam yaus hnub nyoog txog 12 xyoos thiab lub cev hnyav dua 40 kg (rau ntsiav tshuaj 250 mg / 125 mg lossis 500 mg / 125 mg, lossis 875 mg / 125 mg),

- cov menyuam yaus hnub nyoog txog 3 hlis (rau hmoov rau kev npaj ncua kev kawm ntawv ntawm qhov ncauj 200 mg / 28.5 mg thiab 400 mg / 57 mg),

- lub raum tsis ua haujlwm (CC ≤ 30 ml / min) - (rau cov ntsiav tshuaj 875 mg / 125 mg, rau hmoov rau kev ncua rau kev tswj hwm qhov ncauj 200 mg / 28.5 mg thiab 400 mg / 57 mg),

- phenylketonuria (rau hmoov rau kev ncua rau kev tswj hwm qhov ncauj).

Ceev faj: lub siab ua haujlwm tsis zoo.

Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.

Txhawm rau kom zoo thiab txo qis kev phiv los ntawm lub plab zom mov, Augmentin raug pom zoo kom noj thaum pib noj mov.

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua

1 ntsiav tshuaj ntawm 250 mg / 125 mg 3 zaug / hnub (rau kev kis mob me txog rau mob hnyav), lossis 1 ntsiav tshuaj ntawm 500 mg / 125 mg 3 zaug / hnub, lossis 1 ntsiav tshuaj ntawm 875 mg / 125 mg 2 zaug / hnub, lossis 11 ml ntawm kev ncua ntawm 400 mg / 57 mg / 5 ml 2 zaug / hnub (uas yog sib npaug rau 1 ntsiav tshuaj ntawm 875 mg / 125 mg).

2 ntsiav tshuaj ntawm 250 mg / 125 mg tsis sib npaug rau 1 ntsiav tshuaj ntawm 500 mg / 125 mg.

Cov menyuam yaus hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua 40 kg

Cov tshuaj yog sau tseg hauv daim ntawv ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj.

Kev suav qhov ntsuas yog ua raws li hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg lub cev qhov hnyav / hnub (xam raws li amoxicillin) lossis hauv ml ntawm kev ncua.

Qhov ntau yam pauv ntawm qhov kev ncua 125 mg / 31.25 mg hauv 5 ml - 3 zaug / hnub txhua 8 teev

Qhov ntau yam ntawm kev ncua 200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml - 2 zaug / hnub txhua 12 teev.

Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.

Augmentin dosing regimen table (suav muab tshuaj rau amoxicillin)

Kev txhaj tshuaj qis ntawm Augmentin yog siv los kho cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau cov mob tonsillitis.

Kev txhaj tshuaj ntau ntawm Augmentin yog siv los kho cov kab mob xws li otitis media, sinusitis, kis kab mob ntawm txoj hlab ntsws qis thiab mob txeeb zig, kis kab mob ntawm cov pob txha thiab pob qij txha.

Muaj cov ntaub ntawv kuaj mob tsis txaus kom pom zoo siv cov tshuaj Augmentin ntau dua 40 mg / kg / hnub hauv 3 koob tshuaj (4: 1 ncua kev kawm) rau cov menyuam yaus hnub nyoog qis dua 2 xyoos.

Cov menyuam txij thaum yug mus txog 3 hlis

Vim lub cev tsis muaj nuj nqi ntawm qhov ua tau zoo tshaj plaws ntawm lub raum, qhov pom zoo koob tshuaj Augmentin (xam raws li amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj hauv daim ntawv 4: 1 ncua kev ncua.

Kev siv qhov kev ncua 7: 1 (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml) tsis pom zoo rau cov neeg no.

Cov menyuam yug ua ntej

Tsis muaj cov lus qhia hais txog qhov muab tshuaj.

Cov neeg laus cov neeg mob

Tsis tas yuav txhaj ib koob. Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, qhov koob tshuaj yuav tsum tau kho raws li cov lus qhia rau cov neeg laus uas lub raum tsis ua haujlwm.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug kwv yees QC cov txiaj ntsig.

Feem ntau, yog tias ua tau, kev kho mob rau cov niam txiv yuav tsum yog qhov zoo dua.

Cov neeg mob Hemodialysis

Kev hloov pauv koob tshuaj yog ua raws li qhov siab tshaj plaws ntawm kev tso cai ntawm amoxicillin: 2 tab. 250 mg / 125 mg hauv ib koob tshuaj txhua 24 teev, lossis 1 daim pib. 500 mg / 125 mg nyob rau hauv ib koob txhua 24 teev, lossis ncua kev ncua ntawm 15 mg / 3.75 mg / kg 1 zaug / hnub.

Ntsiav tshuaj: thaum lub caij ntu mob hemodialysis, ib qho ntxiv 1 koob tshuaj (ib ntsiav tshuaj) thiab 1 koob tshuaj ntxiv (ib ntsiav tshuaj) tom qab kawg ntawm kev lim ntshav (kom them rau qhov txo qis hauv cov ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Raug tshem tawm: ua ntej kev kho mob hemodialysis, ib qho koob tshuaj ntxiv ntawm 15 mg / 3.75 mg / kg yuav tsum tau ua haujlwm. Txhawm rau kom rov qab ua dua qhov kev coj ua ntawm cov tshuaj nquag Augmentin hauv cov ntshav, ntxiv ib koob thib ob ntawm 15 mg / 3.75 mg / kg yuav tsum tau muab tom qab kev kho mob hemodialysis.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los kho qhov tshuaj ntau npaum li cas hauv pawg neeg mob no.

Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawv

Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug.

Ncua (125 mg / 31.25 mg hauv 5 ml): kwv yees li 60 ml ntawm dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, ua kom lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias ua tiav kev yug tsiaj. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 92 ml ntawm dej yog xav tau los npaj qhov kev ncua. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm kev ncua ntawm kev siv tshuaj Augmentin tuaj yeem raug txhaws ib nrab nrog dej.

Ncua (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml): ntxiv kwv yees li 40 ml ntawm cov dej rhaub txias rau chav kub mus rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, muab rau sawv ntsug ntawm lub vial rau 5 feeb kom paub meej kev ua tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 64 ml ntawm dej yog xav tau los npaj qhov kev ncua. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug qhov tseeb ntawm cov tshuaj, siv lub hau ntsuas lossis cov koob txhaj tshuaj, uas yuav tsum tau ntxuav nrog dej zoo tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm kev ncua ntawm kev siv tshuaj Augmentin tuaj yeem tov nrog dej hauv qhov sib piv ntawm 1: 1.

Cov xwm txheej tsis zoo uas tau nthuav tawm hauv qab no yog teev raws li kev puas tsuaj rau cov kabmob thiab cov nruab nrog cev thiab qhov ntau zaus tshwm sim. Qhov ntau zaus ntawm kev tshwm sim tau txiav txim siab raws li hauv qab no: ntau zaus (≥1 / 10), feem ntau (≥1 / 100, 30 ml / min

Augmentin 625 - ib txoj kev kho zoo rau kev mob prostatitis

Hauv kev kho mob ntawm ntau yam mob cuam tshuam rau cov neeg laus thiab menyuam yaus, cov tshuaj Augmentin (lwm lub npe lag luam yog Amoxiclav) tau siv. Vim tias nws cov txiaj ntsig zoo, cov tshuaj feem ntau tau sau tseg los ntawm cov kws kho mob ntawm ntau yam tshwj xeeb. Cov tshuaj ua ke ntawm cov tshuaj tua kab mob sib xyaw ua ke tua cov kab mob pathogenic, tiv thaiv cov synthesis ntawm cov phab ntsa hauv lawv lub hlwb.

Cov cai ntawm cov cim khaus khaus thiab kho tshuaj: J01CR02.

Cov tshuaj ua ke ntawm cov tshuaj tua kab mob sib xyaw ua ke Augmentin rhuav tshem cov kab mob pathogenic, tiv thaiv cov synthesis ntawm phab ntsa hauv lawv lub hlwb.

2 Cov qauv sib xyaw thiab ntau npaum cov ntawv

Augmentin muab 2 yam tshuaj uas nquag: amoxicillin (Amoxicillin) thiab clavulanic acid (clavulanic acid). Amoxicillin nyob rau hauv cov npe tseem ceeb uas tsim los ntawm WHO.

Cov qauv tshuaj tua kab mob:

• Augmentin ntsiav tshuaj 375 mg, 625 mg thiab 1000 mg,
• hmoov rau dilution, los ntawm kev uas rho tawm kev tswj hwm rau qhov ncauj lossis ib txoj kev daws rau kev txhaj tshuaj (tshwj xeeb rau txoj leeg) tau npaj.

1 ntsiav tshuaj ntawm Augmentin 625 muaj 500 mg ntawm amoxicillin trihydrate thiab 125 mg ntawm potassium clavulanate.

• compound ntawm cov hmoov txhuv nplej siab thiab sodium,
• silicon dioxide
• magnesium stearate,
• microcrystalline cellulose.

Augmentin muaj nyob hauv cov hmoov tshuaj ua rau kev rov ua dua tshiab, los ntawm qhov kev ncua ntawv yog npaj rau kev tswj hwm qhov ncauj.

Cov ntsiav tshuaj muaj lub plhaub zaj duab xis, uas suav nrog:

• hypromellose (polymer),
• dimethicone (silicone),
• titanium dioxide (zas dawb),
• macrogol (laxative).

Kev ntim ntawm Augmentin 625: 7 lossis 10 daim hauv txhuas ntawv ci, 1 lossis 2 lub hlwv hauv lub thawv nrog silica gel thiab cov lus qhia.

6 Yuav noj li cas Augmentin 625

Txhawm rau cov tshuaj kom zoo dua qub thiab qhov ntxim nyiam ntawm cov kev mob tshwm sim kom tsawg, cov neeg tsim khoom pom zoo siv cov ntsiav tshuaj thaum pib noj mov. Cov koob tshuaj yog xaiv noj rau hauv tus lej hom, qhov mob hnyav ntawm lub pathology, hnub nyoog, qhov hnyav thiab mob ntawm tus neeg mob lub raum. Cov tshuaj uas muaj tsawg tsawg ntawm Augmentin tau raug tshuaj rau cov kab mob txhab ntawm cov nqaij mos, tawv nqaij, tonsillitis nrog rov huam mob ntau dua. Kev siv tshuaj ntau kawg yog xav kho tus mob sinusitis, otitis media, mob rau lub ntsws, mob pleura, pob txha, thiab txoj hlab zis.

Nrog cov kab mob kev mob nyhav, cov neeg laus thiab cov neeg hluas hnub nyoog dhau 12 xyoos feem ntau tau tshaj tawm kom noj 1 ntsiav tshuaj ntawm cov tshuaj tua kab mob 375 mg peb zaug ib hnub, thiab nyob rau kis mob hnyav, 1 ntsiav tshuaj 625 mg. Nws yuav tsum tau yug los hauv lub siab tias 1 ntsiav tshuaj ntawm Augmentin 625 mg tsis sib npaug rau 2 ntsiav tshuaj ntawm 375 mg. Kev hloov los ntawm txoj kev txhaj tshuaj ntawm kev siv tshuaj rau kom noj cov ntsiav tshuaj yog xyaum.

Rau cov menyuam yaus hnub nyoog qis dua 12 xyoos, cov tshuaj yog nyob hauv daim ntawv ntawm cov kua dej (nws yog npaj los ntawm hmoov). Nkag ib zaug ntawm cov tshuaj tua kab mob muab rau tus menyuam peb zaug ib hnub yuav raug suav rau hauv nws lub hnub nyoog:

• 9 lub hlis - 2 xyoos: 62.5 mg,
• 2-7 xyoos: 125 mg,
• 7-12 xyoo: 250 mg.

Qhov koob pom zoo ntawm 4: 1 ncua kev kawm ntawv rau cov menyuam yaus los ntawm 1 mus rau 3 hlis yog 30 mg (rau amoxicillin) rau 1 kg ntawm qhov hnyav, uas tau muab rau hauv 2 koob tshuaj. Cov chaw soj ntsuam kuaj mob tsis txaus siv tshuaj ntau dua 40 mg + 10 mg / kg hauv 3 koob tshuaj rau cov menyuam hnub nyoog qis dua 2 xyoos.

Lub sijhawm kho nrog Augmentin yog los ntawm 5 mus rau 14 hnub.

Thaum xaiv cov tshuaj ntau npaum li cas, nws yog ib qho tsim nyog yuav tau txiav txim siab seb tus neeg mob puas muaj qhov pheej hmoo. Nov yog:

1. Cov neeg mob uas muaj qhov tsis sib xws hauv kev ua haujlwm ntawm lub raum. Cov koob tshuaj tua kab mob ntau kawg yog pom zoo kom muab cov tshuaj creatinine tshem tawm. Cov tshuaj zoo tshaj plaws muab tso quav tshuaj.
2. Cov neeg mob muaj kab mob siab. Kev saib xyuas ntu ntawm lub xeev ntawm kev hloov yog qhov tsim nyog.
3. Qub neeg. Dosage kev kho kom haum yog tsis tsim nyog yog tias tsis muaj kev pathologies ntawm ob lub raum thiab mob siab.
4. Cov neeg mob uas yuav tsum muaj mob hemodialysis. Cov koob tshuaj pom zoo: 1 ntsiav tshuaj Augmentin 625 mg rau ib hnub. Ntxiv: ua ntej thiab tom qab cov txheej txheem - 1 ntsiav tshuaj.

Cov neeg laus tsis tas yuav muab tshuaj kho yog tias tsis muaj cov kab mob ntawm lub raum thiab nplooj siab.

7 Cov lus qhia tshwj xeeb

Ua ntej yuav pib nrog cov tshuaj tua kab mob, nws yog qhov yuav tsum tau paub yog tias tus neeg mob yav dhau los nws muaj kev fab tshuaj rau penicillins lossis cephalosporins. Kev mob tshwm sim ntawm qhov tsis nco qab yog muaj tsawg kawg. Thaum cov tsos mob ntawm kev mob siab rau penicillins tshwm sim, cov tshuaj tiv thaiv yuav tsum tau muab tshem tawm sai sai. Epinephrine thiab corticosteroids kev txhaj tshuaj, oxygenation (khoom cuav ntawm lub cev lub cev muaj cov pa oxygen), kev tawm tsam (nthuav dav lub cev ua pa thim rov qab ua pa) pab tshem tus neeg mob los ntawm kev mob hnyav.

Nrog rau kev tswj hwm tib lub sijhawm ntawm Augmentin nrog cov tshuaj anticoagulant hauv cov ntsiav tshuaj, qee zaum nws yuav tsum tsim nyog txhawm rau txhawm rau txhawm rau txhawm rau kom ua tiav cov txiaj ntsig.

Kev siv tshuaj tua kab mob ntev, tshwj xeeb tshaj yog cov koob tshuaj ntau, feem ntau ua rau kev txhim kho ntawm dysbiosis, ua haujlwm tsis zoo ntawm cov kab mob hematopoietic thiab cov raum. Yog tias cov creatinine tshem tawm tsawg dua 30 ml / min, tsuas yog Augmentin ntsiav tshuaj 625 mg thiab 375 mg, ncua kev kawm 125 + 31.25 mg, txhaj tshuaj 500 + 100 mg thiab 1000 + 200 mg tau tso cai.

Yog tias koj xav tias mononucleosis ntawm ib hom kab mob, koj yuav tsum tsis txhob sau cov tshuaj, vim tias amoxicillin feem ntau ua rau cov tawv nqaij ua pob raws cov yam ntxwv ntawm mob qhua pias. Xws li cov tsos mob tuaj yeem ua rau pom qhov tsis tseeb.

Thaum kho nrog cov tshuaj tua kab mob loj, yuav tsum haus dej ntau kom tsis txhob muaj cov tshuaj amoxicillin hauv lub zais zis. Kev xav zoo ntawm cov tshuaj hauv cov zis tuaj yeem ua rau qhov ntsuas tsis muaj tseeb ntawm cov zis zoo. Nws raug nquahu tias kev sim hauv chaw sim tau siv hom glucose oxidant.

Kev taw qhia rau kev siv

Cov kab mob kis tau los ntawm cov tshuaj lom neeg lub cev:

• kev kis mob ntawm cov mob ua pa sab saud thiab ENT kabmob (piv txwv li tonsillitis, sinusitis, otitis media), feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes,
• cov kab mob ua pa tsawg dua: exacerbations ntawm mob ntsws ntev, lobar mob ntsws thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae thiab Moraxella catarrhalis (tshwj tsis yog ntsiav tshuaj 250 mg / 125 mg),
• mob txeeb zig: cystitis, urethritis, pyelonephritis, kis mob rau poj niam lub cev, ua feem ntau los ntawm hom kab mob Enterobacteriaceae (feem ntau Escherichia coli *), Staphylococcus saprophyticus thiab hom kab mob ntawm genus Enterococcus,
• kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae (tshwj tsis yog 250 mg / 125 mg ntsiav tshuaj),
• kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus, Streptococcus pyogenes thiab hom ntawm lub genus Bactero> Kev Siv Tshuaj thiab kev tswj hwm

Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.

Txhawm rau kom zoo thiab txo qis kev phiv los ntawm lub plab zom mov, Augmentin raug pom zoo kom noj thaum pib noj mov.

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Cov Yuav Tsum Muaj

• cov tshuaj tiv thaiv tsis haum rau amoxicillin, clavulanic acid, lwm yam tshuaj, tshuaj tua kab mob beta-lactam (piv txwv li penicillins, cephalosporins) hauv anamnesis,
• yav dhau los lub sijhawm daj ntseg lossis lub siab ua kom lub siab ua haujlwm thaum siv amoxicillin nrog clavulanic acid hauv keeb kwm
• cov me nyuam qis dua 12 xyoos thiab lub cev hnyav dua 40 kg

Cia rau cov neeg mob

Cov tshuaj yuav tsum muab khaws cia kom deb ntawm qhov ncav cuag ntawm cov menyuam ntawm qhov kub tsis tshaj li 25 ° C.

Hauv ib qhov ncauj ntsiav tshuaj muaj 0.25, 0.5 lossis 0.875 g amoxicillin trihydrate thiab 0.125 g clavulanic acid (hauv kev tsim cov tshuaj, clavulanate sodium yog tso nrog 5% ntau dhau).

Hauv tshuaj ntsiav ntu ntu: Silicii dioxideydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Ib fwj hmoov rau kev npaj daws rau kev txhaj tshuaj muaj 0.5 lossis 1 g amoxicillin trihydrate thiab, feem, 0.1 lossis 0.2 g clavulanic acid.

Cov muaj pes tsawg leeg Augmentin hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj suav nrog 0.125 / 0.2 / 0.4 g (5 ml) amoxicillin trihydrate thiab, feem, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Xanthan ntawm cov pos hniav, Hydroxypropyl methylcellulose, Silicii dioxideydum colloidale, Acidum succinicum, Silicii dioxideydum, Aspartamum (E951), qhuav - txiv kab ntxwv tsw qab (610271E thiab 9/027108), txiv pos thiab "Bright molasses".

Hauv hmoov Augmentin EU npaj rau kev npaj ntawm 100 ml ntawm kev ncuamuaj 0.6 g (5 ml) amoxicillin trihydrate thiab 0.0429 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Silicii dioxideydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan ntawm cov pos hniav, Silicii Dydydum, tsw tsw qab 544428.

Hauv qhov muaj pes tsawg leeg ntawm ib qho Augmentin CP ntsiav tshuaj nrog rau kev ua ntev nrog rau 1 g amoxicillin trihydrate thiab 0.0625 g clavulanic acid.

Ntu Cheebtsam: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxideydum colloidale, Magnesium stearate, Xanthan ntawm cov pos hniav, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum

Cov tshuaj muaj daim ntawv tso tawm hauv qab no:

• Augmentin ntsiav tshuaj 250 mg + 125 mg, Augmentin 500 mg + 125 mg thiab Augmentin 875 + 125 mg.
• Hmoov 500/100 mg thiab 1000/200 mg, npaj rau kev npaj ntawm kev daws rau kev txhaj tshuaj.
• Hmoov rau kev ncua ncua Augmentin 400 mg / 57 mg, 200 mg / 28.5 mg, 125 mg / 31.25 mg.
• Hmoov Augmentin EU 600 mg / 42.9 mg (5 ml) rau kev ncua.
• Augmentin CP 1000 mg / 62.5 mg txhawb cov ntsiav tshuaj tso tawm

Augmentin belongs rau cov pab pawg muab tshuaj kho mob "Cov tshuaj tua kab mob rau kev siv kab ke. -lactams. Penicillins. "

Cov nyhuv pharmacological ntawm cov tshuaj yog Tshuaj tua kab mob thiab tua kab mob.

Pharmacodynamics thiab pharmacokinetics

Raws li Wikipedia, Amoxicillin yog cov kab mob bactericidalzoo tiv thaiv ntau yam kab mob thiab cov kab mob muaj peev xwm cov kab mob me me thiab sawv cev semisynthetic penicillin pawg tshuaj tiv thaiv.

Txhawb pab transpeptidase thiab cuam tshuam nrog kev tsim khoom mureina (qhov tseem ceeb tshaj plaws ntawm cov phab ntsa ntawm cov kab mob hauv lub cev) thaum lub sijhawm faib thiab kev loj hlob, nws provokes li lysis (kev rhuav tshem) cov kab mob.

Amoxicillin raug rhuav tshem -lactamasesyog li nws cov kev ua haujlwm tiv thaiv kab mob tsis txuas ntxiv cov kab mob me metsim khoom -lactamases.

Ua raws li kev sib tw thiab nyob rau hauv feem ntau ntawm ib tug tsis tuaj yeem inhibitor, clavulanic acid tsiag ntawv los ntawm kev muaj peev xwm txeem ntxeem phab ntsa cov kab mob thiab ua rau inactivation cov enzymesuas muaj nyob ntawm ob sab ntawm tes thiab ntawm nws cov ciam teb.

Clavulanate cov ntaub ntawv ruaj khov inactivated complexes nrog -lactamasesthiab no nyeg tiv thaiv kev puas tsuaj amoxicillin.

Augmentin tshuaj tua kab mob zoo tiv thaiv:

• Nyiaj Gram (+) aerobes: pyogenic mob streptococcus pawg A thiab B, pneumococci, Staphylococcus aureus thiab mob sab nrauv, (tshwj tsis yog zam ntawm kab mob methicillin-tiv taus lim tawm), saprophytic staphylococcus thiab lwm tus
• Nyiaj Gram (-) aerobes: Pfeiffer nrog, mob hnoos hawb pob, gardnerella vaginalis , Mob raws plab lwm yam.
• Gram (+) thiab Gram (-) ntawm anaerobes: bacteroids, fusobacteria, preotellas lwm yam.
• Lwm yam kab mob me me: mob chlamydia, spirochete, daj ntseg treponema lwm yam.

Tom qab kev siv cov tshuaj Augmentin, ob qho ntawm nws lub cev ua kom nrawm nrawm thiab nqus tawm ntawm qhov hnyuv. Kev nqus tau yog qhov zoo dua yog tias ntsiav tshuaj lossis kua dej cawv thaum noj mov (thaum pib noj mov).

Ob qho tib si thaum noj ntawm qhov ncauj, thiab nrog cov lus qhia ntawm Augmentin IV kev daws teeb meem, kev kho tshuaj ntau ntawm cov tshuaj ua kom muaj zog nyob hauv txhua cov ntaub so ntswg thiab cov kua dej ua kua interstitial.

Ob leeg lub zog ua kom tsis muaj zog khi rau ntshav ntshav protein (txog 25% khi rau cov ntshav protein amoxicillin trihydrate thiab tsis ntau tshaj 18% clavulanic acid) Tsis muaj qhov mus ntxiv ntawm Augmentin raug kuaj pom ib qho ntawm cov kabmob hauv nruab nrog.

Amoxicillin nphav raug kev zom mov nyob rau hauv lub cev thiab excreted ob lub raumlos ntawm kev zom cov pa zom zaws thiab hauv daim ntawv cov roj carbon dioxide nrog rau cov pa tawm kom zoo. 10 txog 25% ntawm qhov koob tau txais amoxicillin raug zam ob lub raum hauv daim ntawv penicilloic aciduas yog nws tsis tsaug zog metabolite.

Clavulanate raug tawm ob leeg los ntawm lub raum thiab los ntawm txoj kev ua cov txheej txheem ntxiv.

Kev ntsuas rau siv

Kev taw qhia rau kev siv ntawm kev sib xyaw amoxicillin trihydrate thiab clavulanic acid yog kis tau tus mobprovoked los ntawm rhiab rau qhov kev txiav txim ntawm cov tshuaj no cov kab mob me me.

Kev kho mob Augmentin tseem raug tso cai. kis tau tus mobtshwm sim los ntawm kev ua si cov kab mob me merhiab rau kev txiav txim amoxicillinthiab li sib xyaw kis tau tus mobprovoked los ntawm rhiab rau cov kab mob amoxicillin thiab cov kab mob uas tsim tawm -lactamase thiab raug cim los ntawm rhiab xav rau kev sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Hauv Is Taws Nem, cov lus nug feem ntau nug “Cov ntsiav tshuaj Augmentin yog los ntawm dab tsi? "Los sis" Augmentin Syrup Curing yog dab tsi? ".

Kev thaj tsam ntawm cov tshuaj no nws kim heev. Nws yog tshuaj rau hauv qab no kab mob sib kis thiab kab mob:

• ntawm kis tau tus mobcuam ​​tshuam qaum thiab qis cov pa ua pa (suav nrog suav nrog Cov mob ENT),
• ntawm kis tau tus mobcuam ​​tshuam genitourinary huam,
• ntawm odontogenic (mob hauv qhov ncauj) mob,
• ntawm cov kab mob gynecological,
• ntawm gonorrhea,
• ntawm kis tau tus mobcuam ​​tshuam daim tawv nqaij thiab cov nqaij mos,
• ntawm kis tau tus mobcuam ​​tshuam nqaij pob txha (suav nrog yog tias tsim nyog, kev teem sij hawm ntawm kev kho mob mus ntev rau tus neeg mob),
• lwm yam kis tau tus mob hom sib xyaw (piv txwv li tom qab septic rho menyuamntawm sepsis nyob rau lub sijhawm ua haujlwm tom qab yug menyuam tas, nrog septicemia (sepsis tsis muaj metastases), mob peritonitisntawm sepsistshwm sim los ntawm kev kis tus mob intraabdominalntawm kis tau tus mobtsim tom qab kev phais mob).

Augmentin feem ntau yog siv los tiv thaiv kev ntsuas ua ntej ua cov kev phais loj rau kev ua haujlwm taub hau, caj dab, lub plab zom mov, lub raum, mob plab, ntawm cov kabmob uas nyob hauv plab hu ua pelvic.thiab raws li thaum lub sij hawm tus txheej txheem cog cov khoom hauv nruab nrog cev.

Augmentin nyob rau hauv txhua daim ntawv qhia cov tshuaj yog contraindicated:

• cov neeg mob uas lub siab tsis haum rau ib lossis ob qho kev sib txuas ntawm cov tshuaj, rau ib qho ntawm nws qhov kev tshem tawm, ntxiv rau -lactam (i.e. to tshuaj tua kab mob los ntawm tej pab pawg tshuaj penicillin thiab cephalosporin),
• cov neeg mob uas tau ntsib kev kho mob ntawm Augmentin kho mob dajntoo lossis keeb kwm ntawm qhov tsis taus zoo mob siab vim kev siv tshuaj sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Ib qho kev tiv thaiv ntxiv rau kev teem caij ua hmoov rau kev npaj ntawm qhov ncauj tshem tawm nrog qhov ntau npaum ntawm cov tshuaj dej ntawm 125 + 31.25 mg yog PKU (phenylketonuria).

Lub hmoov siv rau kev npaj ntawm qhov ncauj ncua nrog qhov ntau npaum ntawm cov tshuaj dej (200 + 28.5) thiab (400 + 57) mg yog contraindicated:

• ntawm PKU,
• cov neeg mob uas tsis taus raumntawm qhov ntsuas Reberg kev ntsuam xyuas hauv qab no 30 ml ib feeb
• cov menyuam yaus hnub nyoog qis dua 3 hlis.

Ib qho kev tiv thaiv ntxiv rau kev siv cov ntsiav tshuaj nrog cov tshuaj ntau dua (250 + 125) thiab (500 + 125) mg yog lub hnub nyoog qis dua 12 xyoos thiab / lossis hnyav dua 40 phaus.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm cov tshuaj nquag 875 + 125 mg yog contraindicated:

• ua txhaum txoj haujlwm kev ua haujlwm raum (ntsuas Reberg kev ntsuam xyuas hauv qab 30 ml ib feeb)
• cov me nyuam qis dua 12 xyoos
• cov neeg mob uas lub cev tsis hnyav tshaj 40 kg.

Kev phiv los ntawm Augmentin tuaj yeem tshwm sim los ntawm ntau lub tshuab thiab ib tus kabmob. Feem ntau cov feem ntau, tiv thaiv keeb kwm ntawm kev siv tshuaj kho yeeb tshuaj, cov kev coj ua hauv qab no tuaj yeem pom:

• candidiasis (pom quav) ntawm daim tawv nqaij thiab mucous daim nyias nyias,
• zawv plab (ntau zaus - thaum noj Augmentin hauv cov ntsiav tshuaj, feem ntau thaum noj ncua lossis txhaj tshuaj),
• bouts ntawm xeev siab thiab ntuav (xeev siab feem ntau tshwm sim thaum noj cov tshuaj hauv qhov siab).

Tej kev phiv uas tshwm sim muaj xws li:

• kiv taub hau,
• mob taub hau,
• dysfunctions kev zom plab,
• nce ntxiv hauv daim siab enzyme ua si alanine transaminases (ALT) thiab kev hloov chaw aspartate (AST),
• daim tawv nqaij ua pob, khaus tawvqhov kev tshwm sim urticaria.

Tsawg zaus, lub cev tuaj yeem teb rau kev txais tos ntawm Augmentin:

• thim rov qab leukopenia (suav nrog suav nrog agranulocytosis),
  thrombocytopenia,
• kev txhim kho thrombophlebitis ntawm qhov chaw txhaj tshuaj
• polymorphic erythema.

Tsis tshua muaj neeg tuaj yeem txhim kho:

• hemolytic anemia,
• tej yam kev mob uas pom los ntawm kev nce hauv lub sijhawm los ntshav thiab nce ntxiv prothrombin Performance index,
• kev tawm tsam los ntawm lub cev tiv thaiv kab mobuas qhia raws li angioedema, ib qho syndrome zoo ib yam li qhov tshwm sim hauv ntshiab ntshav mob, anaphylaxis, ua xua vasculitis,
• hyperactivity hom reversible
• nce pom kev ua si,
• tus kausvim kev txais tos tshuaj tua kab mobsuav nrog suav nrog pseudomembranous (PMK) thiab hemorrhagic (qhov ntxim nyiam ntawm kev txhim kho tom kawg poob qis yog tias Augmentin raug tswj hwm los ntawm niam txiv),
• keratinization thiab kev loj hlob ntawm tus nplaig zoo li tus papillae nyob ntawm tus nplaig (kab mob hu ua “tus nplaig plaub hau dub”),
• kab mob siab thiab mob siab cholestasis,
• Lyell cov tsos mob,
• feem ntau exanthematous pustulosis nyob rau hauv daim ntawv mob
• interstitial nephritis,
• cov tsos hauv cov zis ntawm ntsev muaju (crystalluria).

Thaum muaj dermatitis kev ua xua kev kho mob Augmentin yuav tsum tsis ua mus ntxiv.

Cov lus qhia rau kev siv Augmentin: txoj kev thov, ntau npaum li cas rau cov neeg laus thiab menyuam yaus

Ib qho ntawm cov lus nug feem ntau ntawm tus neeg mob yog cov lus nug txog kev noj tshuaj ua ntej lossis tom qab noj mov. Nyob rau hauv rooj plaub ntawm Augmentin, kev noj tshuaj yog ze ze rau kev noj mov. Nws yog suav hais tias yog qhov zoo tshaj rau noj cov tshuaj ncaj qha. ua ntej noj mov.

Ua ntej, nws muab kev nqus zoo dua ntawm lawv cov tshuaj nquag Kev kho mob txoj hnyuv, thiab, ob, nws tuaj yeem txo qhov hnyav Mob plab zom mov tsis haum ntawm lub plab zom movyog tom kawg ntawv xwb.

Yuav ua li cas los xam cov koob tshuaj ntawm Augmentin

Yuav ua li cas noj cov tshuaj Augmentin rau cov neeg laus thiab menyuam yaus, nrog rau nws txoj kev kho kom haum, nyob ntawm seb qhov twg microorganism yog ib tug kab mob, kev rhiab npaum li cas yog nws raug tshuaj tua kab mob, qhov mob hnyav thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob, kev ua kom pom ntawm thaj chaw sib kis, lub hnub nyoog thiab qhov hnyav ntawm tus neeg mob, nrog rau nws noj qab haus huv npaum li cas ob lub raum tus neeg mob.

Lub sijhawm tiv thaiv ntawm cov chav kho yog nyob ntawm seb tus neeg mob lub cev teb li cas rau kev kho mob.

Augmentin ntsiav tshuaj: cov lus qhia rau kev siv

Ua raws li cov ntsiab lus ntawm cov tshuaj yeeb dej caw hauv lawv, Augmentin ntsiav tshuaj raug pom zoo rau cov neeg mob laus kom noj raws li cov qauv hauv qab no:

• Augmentin 375 mg (250 mg + 125 mg) - ib peb zaug ib hnub. Hauv kev siv ntau npaum li cas, cov tshuaj tau qhia rau kis tau tus mobuas ntws hauv yooj yim lossis tsim nyog me. Thaum muaj mob hnyav, suav nrog mob ntev thiab rov tshwm sim, ntau dua qhov tau muab tshuaj.
• Cov ntsiav tshuaj 625 mg (500 mg + 125 mg) - ib peb zaug ib hnub.
• 1000 mg ntsiav tshuaj (875 mg + 125 mg) - ib hnub ob zaug.

Qhov hno yog raug rau kev kho rau cov neeg mob uas tsis muaj lub luag haujlwm. raum.

Augmentin CP 1000 mg / 62.5 mg cia cov ntsiav tshuaj tso tawm tsuas yog pub rau cov neeg mob hnub nyoog 16 xyoo rov hauv. Cov koob tshuaj zoo yog ob ntsiav tshuaj ib hnub ob zaug.

Yog tias tus neeg mob tsis tuaj yeem nqos tag nrho cov ntsiav tshuaj, nws muab faib ua ob kab raws txoj kab txhaum. Ob qho tib si ob leeg tau coj tib lub sijhawm.

Cov neeg mob nrog rau cov neeg mob ob lub raum cov tshuaj yog kws kho tsuas yog hauv qhov xwm txheej ntawm qhov ntsuas Reberg kev ntsuam xyuas ntau tshaj 30 ml tauj ib feeb (uas yog, thaum kho kom haum rau qhov tshuaj ntau npaum li cas tsis tas yuav).

Hmoov rau cov tshuaj rau kev txhaj tshuaj: cov lus qhia rau kev siv

Raws li cov lus qhia, txoj kev daws teeb meem yog txhaj rau hauv txoj leeg: los ntawm dav hlau (qhov koob tshuaj yuav tsum tau txhaj tshuaj hauv 3-4 feeb) lossis los ntawm cov txheej txheem dej (lub sijhawm ntawm Txoj kev lis ntshav yog los ntawm ib nrab ntawm ib teev mus rau 40 feeb). Txoj kev daws tsis tau xav kom tau txhaj tshuaj rau hauv cov leeg.

Cov qauv muab rau ib tus neeg mob laus yog 1000 mg / 200 mg. Nws raug nquahu kom nkag nws txhua yim teev, thiab rau cov uas muaj teeb meem kis tau tus mob - txhua rau lossis rau plaub teev (raws li qhia).

Tshuaj tua kab mob hauv kev txiav txim siab ntawm tshuaj, 500 mg / 100 mg lossis 1000 mg / 200 mg yog tau sau tseg rau kev tiv thaiv kev txhim kho kis mob tom qab phais tasCov. Hauv kis uas lub sijhawm ua haujlwm tsawg dua li ib teev, nws txaus rau nkag mus rau tus neeg mob ib zaug ua ntej Tshuaj loog koob tshuaj ntawm Augmentin 1000 mg / 200 mg.

Yog tias nws cia siab tias qhov kev ua haujlwm yuav kav ntev dua li ib teev, txog plaub koob ntawm 1000 mg / 200 mg tau muab rau tus neeg mob nyob rau hnub dhau los rau 24 teev.

Kev ncua Augmentin: cov lus qhia rau kev siv

Cov lus qhia rau kev siv Augmentin rau menyuam yaus pom zoo kom teem sij hawm ncua ntawm 125 mg / 31.25 mg hauv koob tshuaj 2.5 txog 20 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 3 thaum nruab hnub. Qhov ntim ntawm ib koob tshuaj nyob ntawm lub hnub nyoog thiab qhov hnyav ntawm tus menyuam.

Yog tias tus menyuam loj dua ob lub hlis ntawm hnub nyoog, ncua kev ncua 200 mg / 28.5 mg yog tau sau rau hauv koob tshuaj ib yam li 25 / 3.6 mg rau 45 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav. Cov koob tshuaj uas tau hais tseg yuav tsum muab faib ua ob zaug.

Qhov ncua kev kawm ntawv nrog rau qhov ntau npaum ntawm cov tshuaj 400 mg / 57 mg (Augmentin 2) yog qhia rau kev siv pib txij li xyoo. Nyob ntawm seb tus me nyuam muaj hnub nyoog thiab hnyav li cas, ib koob tshuaj nws txawv ntawm 5 mus rau 10 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 2 thaum nruab hnub.

Augmentin EU yog pib txij 3 lub hlis hnub nyoog. Cov koob tshuaj zoo tshaj plaws yog 90 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub (qhov koob tshuaj yuav tsum tau muab faib ua 2 koob, khaws ib ntu 12-teev nruab nrab ntawm lawv).

Niaj hnub no, cov tshuaj hauv ntau hom tshuaj yog ib qho ntawm cov tshuaj tshaj plaws rau kev kho mob. mob qa.

Cov me nyuam Augmentin nrog mob caj pas sau rau hauv lub koob tshuaj uas tau txiav txim siab raws lub cev qhov hnyav thiab hnub nyoog ntawm tus menyuam. Nrog angina rau cov neeg laus, nws raug nquahu kom siv Augmentin 875 + 125 mg peb zaug ib hnub.

Tsis tas li, lawv feem ntau yog mus rau lub sijhawm Augmentin mob hlab ntswsCov. Txoj kev kho yog ntxiv los ntawm kev ntxuav lub qhov ntswg nrog ntsev hiav txwv thiab siv tshuaj txau qhov ntswg ntawm hom RinofluimucilCov. Koob tshuaj zoo rau mob hlab ntsws: 875/125 mg 2 zaug ib hnub. Lub sijhawm ua haujlwm ntawm feem ntau yog 7 hnub.

Tshaj dhau qhov koob ntawm Augmentin tau nrog los ntawm:

• kev txhim kho ntawm kev ua txhaum los ntawm cov hnyuv,
• ua txhaum ntawm dej-ntsev tshuav,
• crystalluria,
• lub raum tsis ua hauj lwm,
• nag lossis daus (nag lossis daus) ntawm amoxicillin nyob rau hauv lub raj tso zis.

Thaum cov tsos mob zoo li no tshwm sim, tus neeg mob tau qhia pom muaj kev kho mob, nrog rau, ntawm lwm yam, kev kho ntawm cov dej-ntsev kom sib npaug.Thim ntawm Augmentin los ntawm rauequilibrium system kuj pab txhawb tus txheej txheem hemodialysis.

Yuam kev tswj fwm cov tshuaj nrog probenecid:

• pab txo kom tsawg tubular zais cia ntawm amoxicillin,
• provokes ib qho kev nce nyob rau hauv concentration amoxicillin hauv ntshav ntshav (cov nyhuv cuam tshuam ntev mus),
• tsis cuam tshuam rau cov khoom thiab theem ntawm cov ntsiab lus hauv clavulanic acid ntshav ntshav.

Sib txuam ua ke amoxicillin nrog allopurinol nce txoj kev nyiam qhov zuj zus ua xuaCov. Cov ntaub ntawv sib cuam tshuam allopurinol ib txhij nrog ob qho kev nquag ntawm Augmentan tsis tuaj.

Augmentin muaj cov nyhuv hauv uas muaj nyob hauv txoj hnyuv microflorauas provokes ib tug txo nyob rau hauv reabsorption (thim rov qab haum) tshuaj estrogen, nrog rau kev txo qis hauv cov txiaj ntsig ntawm kev sib xyaw ua ke tshuaj tiv thaiv rau kev siv qhov ncauj.

Cov tshuaj tsis sib xws nrog cov ntshav cov ntshav thiab cov kua-muaj kua, nrog rau suav nrog whey protein hydrolysates thiab roj emulsions npaj rau kev ntxig rau hauv cov leeg ntshav.

Yog tias Augmentin tawm tshuaj nrog rau tshuaj tua kab mob chav kawm aminoglycosides, cov tshuaj tsis sib xyaw rau hauv ib lub koob txhaj tshuaj lossis lwm lub thauv tshuaj ua ntej kev tswj hwm, vim tias qhov no ua rau tsis muaj zog aminoglycosides.

Kev npaj cov khoom ntim thaum xub thawj yog khaws cia ntawm qhov kub uas tsis tshaj 25 ° C. Qhov tshem tawm yuav tsum khaws cia ntawm qhov kub ntawm 2-8 ° C (zoo tshaj hauv tub yees) tsis pub ntev tshaj 7 hnub.

Nws tsim nyog siv nyob rau hauv 2 xyoos txij li hnub ntawm kev tsim khoom lag luam.

Cov Lus Qhia Txog AugmentinCov kev sib tw rau ATX Qib 4 code:

Augmentin analogs yog cov tshuaj A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

Txhua ntawm cov tshuaj saum toj no yog dab tsi Augmentin tuaj yeem hloov pauv hauv nws qhov tsis tuaj.

Tus nqi ntawm cov khoom tsis txawv txav los ntawm 63.65 txog 333.97 UAH.

Augmentin rau menyuam yaus

Augmentin siv dav hauv kev xyaum tsiaj txhu. Vim qhov tseeb tias nws muaj menyuam yaus daim ntawv tso tawm - kua phoov, nws tuaj yeem siv tau los kho menyuam yaus rau ib xyoos xwb. Kev teeb tsa tshwj xeeb ua rau txais tos thiab qhov tseeb hais tias cov tshuaj muaj cov khoom qab ntxiag.

Rau menyuam tshuaj tua kab mob feem ntau kho mob rau mob caj pasCov. Qhov ntau npaum li cas ntawm kev ncua rau cov me nyuam yog txiav txim siab los ntawm lub hnub nyoog thiab qhov hnyav. Cov koob tshuaj zoo tshaj plaws tau muab faib ua ob koob, sib npaug 45 mg / kg ib hnub, lossis faib ua peb koob, koob tshuaj 40 mg / kg ib hnub.

Kev siv cov tshuaj rau cov menyuam yaus thiab caij nyoog ntau npaum li cas yog nyob ntawm daim ntawv ntau npaum li cas.

Rau cov menyuam yaus lub cev qhov hnyav tshaj 40 kg, Augmentin raug tso cai tib yam li cov neeg laus.

Augmentin phoov rau cov menyuam yaus txog li ib xyoos yog siv hauv qhov ntau ntawm 125 mg / 31.25 mg thiab 200 mg / 28.5 mg. Kev noj tshuaj ntawm 400 mg / 57 mg yog qhia rau cov menyuam yaus tshaj ib xyoos.

Cov menyuam yaus nyob rau hauv hnub nyoog 6-12 xyoo (hnyav dua 19 kg) raug tso cai siv ob qho kev ncua lossis Augmentin hauv cov ntsiav tshuaj. Kev muab tshuaj ntawm lub ntsiav tshuaj daim ntawv tshuaj yog raws li nram no:

• ib ntsiav tshuaj 250 mg + 125 mg peb zaug ib hnub,
• ib ntsiav tshuaj 500 + 125 mg ob zaug ib hnub (daim ntawv teev ntau npaum li no yog txoj kev pom zoo).

Cov menyuam yaus hnub nyoog dhau 12 xyoos raug samfwm kom noj ib ntsiav tshuaj ntawm 875 mg + 125 mg ob zaug ib hnub.

Txhawm rau kom ntsuas qhov tseeb ntawm koob tshuaj Augmentin kev ncua rau cov menyuam muaj hnub nyoog qis dua 3 hlis, nws pom zoo kom ntaus cov lej nrog ib rab koob uas muaj qhov cim. Txhawm rau kom siv txoj kev siv ncua kev kawm ntawv hauv cov menyuam yaus hauv qab ob xyoos, nws tau tso cai kom cov kua dej nrog cov dej hauv qhov piv rau 50/50

Augmentin's analogues, uas yog nws txoj kev hloov pauv chaw muag tshuaj, yog cov tshuaj Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Lub Ecoclave.

Cawv tau zoo

Augmentin thiab cawv yog qhov kev xav tsis yog kev tawm tsam los ntawm cov cawv cawv ethyl tshuaj tua kab mob tsis pauv nws lub zog pharmacological.

Yog tias tawm tsam keeb kwm ntawm kev siv tshuaj yeeb muaj qhov xav kom haus dej haus cawv, nws yog ib qho tseem ceeb kom soj ntsuam ob yam kev mob: kev sim thiab maj nrawm.

Rau tib neeg kev txom nyem los ntawm kev quav dej cawv, kev siv yeeb tshuaj nrog cawv ib txhij tuaj yeem muaj kev phom sij loj dua.

Kev siv dej cawv hauv cov dej cawv ua rau cuam tshuam nrog ntau yam kev ntxhov siab hauv kev ua haujlwm mob siabCov. Cov neeg mob nrog tus neeg mob mob siab cov kev qhia pom zoo hais tias Augmentin yuav tsum muaj kev ceev faj heev, vim tias nws tau kwv yees tias yuav ua li cas lub cev muaj kabmob yuav coj tus cwj pwm hauv kev sim kom tiv thaiv. xenobioticnyuaj heev.

Yog li, yuav kom zam kev pheej hmoo tsis txaus ntseeg, nws raug nquahu kom tsis txhob haus cawv thaum lub sijhawm tag nrho ntawm kev kho nrog cov tshuaj.

Augmentin thaum cev xeeb tub thiab lactation

Zoo li feem ntau cov tshuaj tua kab mob penicillin pawg, amoxicillin, muab faib rau hauv cov ntaub so ntswg ntawm lub cev, tseem nkag rau hauv niam mis. Ntxiv mus, kab lus ntau yuav txawm pom nyob hauv mis. clavulanic acid.

Txawm li cas los xij, tsis muaj kev cuam tshuam loj hauv lub tsev kho mob los ntawm tus mob ntawm tus me nyuam yog sau tseg. Hauv qee kis, kev sib xyaw ua ke clavulanic acid nrog amoxicillin tuaj yeem tsim nyob rau hauv tus menyuam zawv plab thiab / lossis candidiasis (thrush) ntawm cov hnoos qeev hauv lub qhov ncauj kab noj hniav.

Augmentin belongs rau cov qeb ntawm cov tshuaj pub mis pub mis. Yog tias, txawm li cas los xij, tiv thaiv keeb kwm ntawm niam txoj kev kho mob nrog Augmentin, tus me nyuam muaj qee qhov tshwm sim tsis zoo, kev pub mis niam yog tso tseg.

Kev tshawb fawb tsiaj tau pom tias cov tshuaj nquag ntawm Augmentin muaj peev xwm nkag mus hematoplacental (GPB) teeb meemCov. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo rau kev loj hlob ntawm tus menyuam hauv plab.

Ntxiv mus, teratogenic teebmeem tau tsis tuaj nrog niam txiv kev coj noj coj ua thiab tshuaj noj ntawm qhov ncauj.

Kev siv cov Augmentin hauv cov poj niam cev xeeb tub tuaj yeem tuaj yeem coj mus rau kev loj hlob ntawm cov menyuam mos necrotizing enterocolitis (NEC).

Zoo li txhua lwm yam tshuaj, Augmentin tsis pom zoo rau cov poj niam cev xeeb tub. Thaum cev xeeb tub, nws siv tau rau qee qhov xwm txheej, raws li kws kho mob qhov kev ntsuas, qhov txiaj ntsig rau tus poj niam muaj ntau tshaj qhov txaus ntshai rau nws tus menyuam.

Kev txheeb xyuas txog Augmentin

Kev tshuaj xyuas ntawm cov ntsiav tshuaj thiab kev ncua rau cov me nyuam Augmentin rau feem ntau zooCov. Coob tus ntsuas cov tshuaj ua tshuaj tau txais txiaj ntsig zoo thiab ntseeg tau.

Ntawm cov chaw sib tham uas tib neeg qhia txog lawv cov kev xav ntawm qee yam tshuaj, cov qhab nia nruab nrab ntawm cov tshuaj tua kab mob yog 4,3-4.5 ntawm 5 lub ntsiab lus.

Cov kev tshuaj xyuas txog Augmentin tseg los ntawm leej niam ntawm cov menyuam yaus qhia tias cov cuab yeej pab tau daws sai sai nrog cov kab mob xws li mob thaum yau mob ntsws lossis mob caj pasCov. Ntxiv nrog rau qhov ua tau zoo ntawm cov tshuaj, cov niam kuj tseem nco qab nws cov qab ntxiag, uas cov menyuam nyiam.

Cov cuab yeej ua haujlwm kuj tseem muaj txiaj ntsig thaum cev xeeb tub. Txawm hais tias qhov tseeb hais tias qhov kev qhia tsis pom zoo kev kho mob nrog cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub sijhawm 1 lub sijhawm), Augmentin feem ntau yog txiav txim siab thib 2 thiab thib 3 txiav.

Raws li cov kws kho mob, qhov loj tshaj plaws thaum kho nrog cov cuab yeej no yog soj ntsuam qhov ntau npaum li cas thiab ua raws txhua qhov kev pom zoo ntawm koj tus kws kho mob.

Tus nqi ntawm Augmentin hauv Ukraine nws txawv nyob ntawm lub tsev muag tshuaj tshwj xeeb. Nyob rau tib lub sijhawm, tus nqi ntawm cov tshuaj yog me ntsis siab dua hauv cov khw muag tshuaj hauv Kiev, ntsiav tshuaj thiab kua txiv hauv cov chaw muag tshuaj hauv Donetsk, Odessa lossis Kharkov raug muag ntawm tus nqi me ntsis.

625 mg ntsiav tshuaj (500 mg / 125 mg) tau muag hauv khw muag tshuaj, ntawm thaj tsam, ntawm 83-85 UAH. Tus nqi nruab nrab ntawm Augmentin ntsiav tshuaj 875 mg / 125 mg - 125-135 UAH.

Koj tuaj yeem yuav cov tshuaj tua kab mob hauv cov hmoov ntawv rau kev npaj cov tshuaj rau kev txhaj tshuaj nrog qhov tshuaj ntawm 500 mg / 100 mg ntawm cov tshuaj yeeb dej caw, ntawm qhov nruab nrab, rau 218-225 UAH, tus nqi nruab nrab ntawm Augmentin 1000 mg / 200 mg - 330-354 UAH.

Nqe ntawm Augmentin kev ncua rau cov menyuam yaus:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

• Cov Tshuaj Online Online hauv Russia
• Cov chaw muag tshuaj online ntawm UkraineUkraine
• Cov chaw muag tshuaj online hauv Kazakhstan

Augmentin Hmoov 228,5 mg / 5 ml 7.7 g 70 ml GlaxoSmithKline

Augmentin ntsiav tshuaj 250 mg + 125 mg 20 pcs. GlaxoSmithKline

Augmentin Hmoov 642.9 mg / 5 ml 100 ml

Augmentin Hmoov 457 mg / 5 ml 12.6 g 70 ml

Augmentin Hmoov 100 ml GlaxoSmithKline

Augmentin 250mg / 125mg No. 20 ntsiav tshuaj SmithKline Beech PiElSi

Augmentin 125mg / 31.25mg / 5ml 100ml hmoov rau kev ncua ntawv SmithKline Beech PiElSi

Augmentin EU hmoov rau kev ncua 600mg + 42.9mg No. 1 lub raj mis GlaxoSmithKline

Augmentin 1000mg No. 14 ntsiav tshuaj SmithKline Beech PiElSi

Augmentin 200mg / 28.5mg / 5ml 70ml hmoov rau kev ncua ntawv SmithKline Beech PiElSi

Kws tshuaj IFK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

Augmentin SB Pharmaceuticals (UK)

Augmentin tab. 500mg / 125mg No. 14 Velcom Foundation GW (UK)

Augmentin BD ntsiav tshuaj 625mg No. 14 Velcom Foundation GW (UK)

Augmentin SRGlaxo Wellcome Production (Fabkis)

Augmentin hmoov rau qhov kev npaj ntawm txhaj tshuaj tov 600mg No. 10Glaxso Velcom GW (Great Britain)

Pani Cov Tshuaj

Augmentin tom qab ntawd. d / p phoov 228.5mg / 5ml 70ml Glaxo Zoo

Augmentin tom qab ntawd. d / p phoov 228.5mg / 5ml 70ml Glaxo Zoo

Augmentin tom qab ntawd. d / p phoov 228.5mg / 5ml 70ml Glaxo Zoo

Augmentin 500 mg / 125 mg No. 14 ntsiav tshuaj los ntawm SmithKline Beecham Pharmaceuticals (UK)

Augmentin 156 mg / 5 ml 100 ml por.d / phoov SmithKline Beecham Pharmaceuticals (UK)

Augmentin 400mg / 57mg / 5ml 35 ml por.d / susp. SmithKline Beecham Tshuaj (UK)

Augmentin 875 mg / 125 mg No. 14 tabl.smithKline Beecham Pharmaceuticals (Great Britain)

Augmentin 200mg / 28.5mg / 5ml 70 ml por.d / susp. SmithKline Beecham Tshuaj (UK)

THEM SAIB! Cov ntaub ntawv hais txog cov tshuaj ntawm lub xaib yog kev saib xyuas-dav dav, sau los ntawm pej xeem cov chaw thiab tsis tuaj yeem ua lub hauv paus rau kev txiav txim siab txog kev siv tshuaj thaum lub sijhawm kho mob. Ua ntej siv cov tshuaj Augmentin, nco ntsoov sab laj nrog koj tus kws kho mob.

Kev piav qhia cuam tshuam rau 26.09.2014

• Lub npe Latin: Augmentin
• ATX Code: J01CR02
• Yam tshuaj muaj sia: Amoxicillin (Amoxicillin) + Clavulanic acid (Clavulanic acid)
• Chaw tsim tshuaj paus: GlaxoSmithKline plc, UK

Hauv ib qhov ncauj ntsiav tshuaj muaj 0.25, 0.5 lossis 0.875 g amoxicillin trihydrate thiab 0.125 g clavulanic acid(hauv kev tsim cov tshuaj, clavulanate sodium yog tso nrog 5% ntau dhau).

Hauv tshuaj ntsiav ntu ntu: Silicii dioxideydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Ib fwj hmoov rau kev npaj daws rau kev txhaj tshuaj muaj 0.5 lossis 1 g amoxicillin trihydrate thiab, feem, 0.1 lossis 0.2 g clavulanic acid.

Cov muaj pes tsawg leeg Augmentin hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj suav nrog 0.125 / 0.2 / 0.4 g (5 ml) amoxicillin trihydrate thiab, feem, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Xanthan ntawm cov pos hniav, Hydroxypropyl methylcellulose, Silicii dioxideydum colloidale, Acidum succinicum, Silicii dioxideydum, Aspartamum (E951), qhuav - txiv kab ntxwv tsw qab (610271E thiab 9/027108), txiv pos thiab "Bright molasses".

Hauv hmoov Augmentin EU npaj rau kev npaj ntawm 100 ml ntawm kev ncuamuaj 0.6 g (5 ml) amoxicillin trihydrate thiab 0.0429 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Silicii dioxideydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan ntawm cov pos hniav, Silicii Dydydum, tsw tsw qab 544428.

Hauv qhov muaj pes tsawg leeg ntawm ib qho Augmentin CP ntsiav tshuaj nrog rau kev ua ntev nrog rau 1 g amoxicillin trihydrate thiab 0.0625 g clavulanic acid.

Ntu Cheebtsam: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxideydum colloidale, Magnesium stearate, Xanthan ntawm cov pos hniav, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum

Pharmacodynamics thiab pharmacokinetics

Raws li Wikipedia, Amoxicillin yog cov kab mob bactericidalzoo tiv thaiv ntau yam kab mob thiab cov kab mob muaj peev xwm cov kab mob me me thiab sawv cev semisynthetic penicillin pawg tshuaj tiv thaiv.

Txhawb pab transpeptidase thiab cuam tshuam nrog kev tsim khoom mureina (qhov tseem ceeb tshaj plaws ntawm cov phab ntsa ntawm cov kab mob hauv lub cev) thaum lub sijhawm faib thiab kev loj hlob, nws provokes li lysis (kev rhuav tshem) cov kab mob.

Amoxicillin raug rhuav tshem -lactamasesyog li nws cov kev ua haujlwm tiv thaiv kab mob tsis txuas ntxiv cov kab mob me metsim khoom -lactamases.

Ua raws li kev sib tw thiab nyob rau hauv feem ntau ntawm ib tug tsis tuaj yeem inhibitor, clavulanic acid tsiag ntawv los ntawm kev muaj peev xwm txeem ntxeem phab ntsa cov kab mob thiab ua rau inactivation cov enzymesuas muaj nyob ntawm ob sab ntawm tes thiab ntawm nws cov ciam teb.

Clavulanate cov ntaub ntawv ruaj khov inactivated complexes nrog -lactamasesthiab no nyeg tiv thaiv kev puas tsuaj amoxicillin.

Augmentin tshuaj tua kab mob zoo tiv thaiv:

• Nyiaj Gram (+) aerobes: pyogenic mob streptococcus pawg A thiab B, pneumococci, Staphylococcus aureus thiab mob sab nrauv, (tshwj tsis yog zam ntawm kab mob methicillin-tiv taus lim tawm), saprophytic staphylococcus thiab lwm tus
• Nyiaj Gram (-) aerobes: Pfeiffer nrog, mob hnoos hawb pob, gardnerella vaginalis , Mob raws plab lwm yam.
• Gram (+) thiab Gram (-) ntawm anaerobes: bacteroids, fusobacteria, preotellaslwm yam.
• Lwm yam kab mob me me: mob chlamydia, spirochete, daj ntseg treponema lwm yam.

Tom qab kev siv cov tshuaj Augmentin, ob qho ntawm nws lub cev ua kom nrawm nrawm thiab nqus tawm ntawm qhov hnyuv. Kev nqus tau yog qhov zoo dua yog tias ntsiav tshuaj lossis kua dej cawv thaum noj mov (thaum pib noj mov).

Ob qho tib si thaum noj ntawm qhov ncauj, thiab nrog cov lus qhia ntawm Augmentin IV kev daws teeb meem, kev kho tshuaj ntau ntawm cov tshuaj ua kom muaj zog nyob hauv txhua cov ntaub so ntswg thiab cov kua dej ua kua interstitial.

Ob leeg lub zog ua kom tsis muaj zog khi rau ntshav ntshav protein (txog 25% khi rau cov ntshav protein amoxicillin trihydratethiab tsis ntau tshaj 18% clavulanic acid) Tsis muaj qhov mus ntxiv ntawm Augmentin raug kuaj pom ib qho ntawm cov kabmob hauv nruab nrog.

Amoxicillin nphav raug kev zom mov nyob rau hauv lub cev thiab excreted ob lub raumlos ntawm kev zom cov pa zom zaws thiab hauv daim ntawv cov roj carbon dioxide nrog rau cov pa tawm kom zoo. 10 txog 25% ntawm qhov koob tau txais amoxicillin raug zam ob lub raum hauv daim ntawv penicilloic aciduas yog nws tsis tsaug zog metabolite.

Clavulanate raug tawm ob leeg los ntawm lub raum thiab los ntawm txoj kev ua cov txheej txheem ntxiv.

Cov lus qhia rau kev siv Augmentin: txoj kev thov, ntau npaum li cas rau cov neeg laus thiab menyuam yaus

Ib qho ntawm cov lus nug feem ntau ntawm tus neeg mob yog cov lus nug txog kev noj tshuaj ua ntej lossis tom qab noj mov. Nyob rau hauv rooj plaub ntawm Augmentin, kev noj tshuaj yog ze ze rau kev noj mov. Nws yog suav hais tias yog qhov zoo tshaj rau noj cov tshuaj ncaj qha. ua ntej noj mov.

Ua ntej, nws muab kev nqus zoo dua ntawm lawv cov tshuaj nquag Kev kho mob txoj hnyuv, thiab, ob, nws tuaj yeem txo qhov hnyav Mob plab zom mov tsis haum ntawm lub plab zom movyog tom kawg ntawv xwb.

Yuav ua li cas los xam cov koob tshuaj ntawm Augmentin

Yuav ua li cas noj cov tshuaj Augmentin rau cov neeg laus thiab menyuam yaus, nrog rau nws txoj kev kho kom haum, nyob ntawm seb qhov twg microorganism yog ib tug kab mob, kev rhiab npaum li cas yog nws raug tshuaj tua kab mob, qhov mob hnyav thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob, kev ua kom pom ntawm thaj chaw sib kis, lub hnub nyoog thiab qhov hnyav ntawm tus neeg mob, nrog rau nws noj qab haus huv npaum li cas ob lub raum tus neeg mob.

Lub sijhawm tiv thaiv ntawm cov chav kho yog nyob ntawm seb tus neeg mob lub cev teb li cas rau kev kho mob.

Augmentin ntsiav tshuaj: cov lus qhia rau kev siv

Ua raws li cov ntsiab lus ntawm cov tshuaj yeeb dej caw hauv lawv, Augmentin ntsiav tshuaj raug pom zoo rau cov neeg mob laus kom noj raws li cov qauv hauv qab no:

• Augmentin 375 mg (250 mg + 125 mg) - ib peb zaug ib hnub. Hauv kev siv ntau npaum li cas, cov tshuaj tau qhia rau kis tau tus mobuas ntws hauv yooj yim lossis tsim nyog me. Thaum muaj mob hnyav, suav nrog mob ntev thiab rov tshwm sim, ntau dua qhov tau muab tshuaj.
• Cov ntsiav tshuaj 625 mg (500 mg + 125 mg) - ib peb zaug ib hnub.
• 1000 mg ntsiav tshuaj (875 mg + 125 mg) - ib hnub ob zaug.

Qhov hno yog raug rau kev kho rau cov neeg mob uas tsis muaj lub luag haujlwm. raum.

Augmentin CP 1000 mg / 62.5 mg cia cov ntsiav tshuaj tso tawm tsuas yog pub rau cov neeg mob hnub nyoog 16 xyoo rov hauv. Cov koob tshuaj zoo yog ob ntsiav tshuaj ib hnub ob zaug.

Yog tias tus neeg mob tsis tuaj yeem nqos tag nrho cov ntsiav tshuaj, nws muab faib ua ob kab raws txoj kab txhaum. Ob qho tib si ob leeg tau coj tib lub sijhawm.

Cov neeg mob nrog rau cov neeg mob ob lub raum cov tshuaj yog kws kho tsuas yog hauv qhov xwm txheej ntawm qhov ntsuas Reberg kev ntsuam xyuas ntau tshaj 30 ml tauj ib feeb (uas yog, thaum kho kom haum rau qhov tshuaj ntau npaum li cas tsis tas yuav).

Hmoov rau cov tshuaj rau kev txhaj tshuaj: cov lus qhia rau kev siv

Raws li cov lus qhia, txoj kev daws teeb meem yog txhaj rau hauv txoj leeg: los ntawm dav hlau (qhov koob tshuaj yuav tsum tau txhaj tshuaj hauv 3-4 feeb) lossis los ntawm cov txheej txheem dej (lub sijhawm ntawm Txoj kev lis ntshav yog los ntawm ib nrab ntawm ib teev mus rau 40 feeb). Txoj kev daws tsis tau xav kom tau txhaj tshuaj rau hauv cov leeg.

Cov qauv muab rau ib tus neeg mob laus yog 1000 mg / 200 mg. Nws raug nquahu kom nkag nws txhua yim teev, thiab rau cov uas muaj teeb meem kis tau tus mob - txhua rau lossis rau plaub teev (raws li qhia).

Tshuaj tua kab mob hauv kev txiav txim siab ntawm tshuaj, 500 mg / 100 mg lossis 1000 mg / 200 mg yog tau sau tseg rau kev tiv thaiv kev txhim kho kis mob tom qab phais tasCov. Hauv kis uas lub sijhawm ua haujlwm tsawg dua li ib teev, nws txaus rau nkag mus rau tus neeg mob ib zaug ua ntej Tshuaj loog koob tshuaj ntawm Augmentin 1000 mg / 200 mg.

Yog tias nws cia siab tias qhov kev ua haujlwm yuav kav ntev dua li ib teev, txog plaub koob ntawm 1000 mg / 200 mg tau muab rau tus neeg mob nyob rau hnub dhau los rau 24 teev.

Kev ncua Augmentin: cov lus qhia rau kev siv

Cov lus qhia rau kev siv Augmentin rau menyuam yaus pom zoo kom teem sij hawm ncua ntawm 125 mg / 31.25 mg hauv koob tshuaj 2.5 txog 20 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 3 thaum nruab hnub. Qhov ntim ntawm ib koob tshuaj nyob ntawm lub hnub nyoog thiab qhov hnyav ntawm tus menyuam.

Yog tias tus menyuam loj dua ob lub hlis ntawm hnub nyoog, ncua kev ncua 200 mg / 28.5 mg yog tau sau rau hauv koob tshuaj ib yam li 25 / 3.6 mg rau 45 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav. Cov koob tshuaj uas tau hais tseg yuav tsum muab faib ua ob zaug.

Qhov ncua kev kawm ntawv nrog rau qhov ntau npaum ntawm cov tshuaj 400 mg / 57 mg (Augmentin 2) yog qhia rau kev siv pib txij li xyoo. Nyob ntawm seb tus me nyuam muaj hnub nyoog thiab hnyav li cas, ib koob tshuaj nws txawv ntawm 5 mus rau 10 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 2 thaum nruab hnub.

Augmentin EU yog pib txij 3 lub hlis hnub nyoog. Cov koob tshuaj zoo tshaj plaws yog 90 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub (qhov koob tshuaj yuav tsum tau muab faib ua 2 koob, khaws ib ntu 12-teev nruab nrab ntawm lawv).

Niaj hnub no, cov tshuaj hauv ntau hom tshuaj yog ib qho ntawm cov tshuaj tshaj plaws rau kev kho mob. mob qa.

Cov me nyuam Augmentin nrog mob caj pas sau rau hauv lub koob tshuaj uas tau txiav txim siab raws lub cev qhov hnyav thiab hnub nyoog ntawm tus menyuam. Nrog angina rau cov neeg laus, nws raug nquahu kom siv Augmentin 875 + 125 mg peb zaug ib hnub.

Tsis tas li, lawv feem ntau yog mus rau lub sijhawm Augmentin mob hlab ntswsCov. Txoj kev kho yog ntxiv los ntawm kev ntxuav lub qhov ntswg nrog ntsev hiav txwv thiab siv tshuaj txau qhov ntswg ntawm hom RinofluimucilCov. Koob tshuaj zoo rau mob hlab ntsws: 875/125 mg 2 zaug ib hnub. Lub sijhawm ua haujlwm ntawm feem ntau yog 7 hnub.

Cov Lus Qhia Txog Augmentin

Augmentin analogs yog cov tshuaj A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

Txhua ntawm cov tshuaj saum toj no yog dab tsi Augmentin tuaj yeem hloov pauv hauv nws qhov tsis tuaj.

Tus nqi ntawm cov khoom tsis txawv txav los ntawm 63.65 txog 333.97 UAH.

Augmentin rau menyuam yaus

Augmentin siv dav hauv kev xyaum tsiaj txhu. Vim qhov tseeb tias nws muaj menyuam yaus daim ntawv tso tawm - kua phoov, nws tuaj yeem siv tau los kho menyuam yaus rau ib xyoos xwb. Kev teeb tsa tshwj xeeb ua rau txais tos thiab qhov tseeb hais tias cov tshuaj muaj cov khoom qab ntxiag.

Rau menyuam tshuaj tua kab mobfeem ntau kho mob rau mob caj pasCov. Qhov ntau npaum li cas ntawm kev ncua rau cov me nyuam yog txiav txim siab los ntawm lub hnub nyoog thiab qhov hnyav. Cov koob tshuaj zoo tshaj plaws tau muab faib ua ob koob, sib npaug 45 mg / kg ib hnub, lossis faib ua peb koob, koob tshuaj 40 mg / kg ib hnub.

Kev siv cov tshuaj rau cov menyuam yaus thiab caij nyoog ntau npaum li cas yog nyob ntawm daim ntawv ntau npaum li cas.

Rau cov menyuam yaus lub cev qhov hnyav tshaj 40 kg, Augmentin raug tso cai tib yam li cov neeg laus.

Augmentin phoov rau cov menyuam yaus txog li ib xyoos yog siv hauv qhov ntau ntawm 125 mg / 31.25 mg thiab 200 mg / 28.5 mg. Kev noj tshuaj ntawm 400 mg / 57 mg yog qhia rau cov menyuam yaus tshaj ib xyoos.

Cov menyuam yaus nyob rau hauv hnub nyoog 6-12 xyoo (hnyav dua 19 kg) raug tso cai siv ob qho kev ncua lossis Augmentin hauv cov ntsiav tshuaj. Kev muab tshuaj ntawm lub ntsiav tshuaj daim ntawv tshuaj yog raws li nram no:

• ib ntsiav tshuaj 250 mg + 125 mg peb zaug ib hnub,
• ib ntsiav tshuaj 500 + 125 mg ob zaug ib hnub (daim ntawv teev ntau npaum li no yog txoj kev pom zoo).

Cov menyuam yaus hnub nyoog dhau 12 xyoos raug samfwm kom noj ib ntsiav tshuaj ntawm 875 mg + 125 mg ob zaug ib hnub.

Txhawm rau kom ntsuas qhov tseeb ntawm koob tshuaj Augmentin kev ncua rau cov menyuam muaj hnub nyoog qis dua 3 hlis, nws pom zoo kom ntaus cov lej nrog ib rab koob uas muaj qhov cim. Txhawm rau kom siv txoj kev siv ncua kev kawm ntawv hauv cov menyuam yaus hauv qab ob xyoos, nws tau tso cai kom cov kua dej nrog cov dej hauv qhov piv rau 50/50

Augmentin's analogues, uas yog nws txoj kev hloov pauv chaw muag tshuaj, yog cov tshuaj Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Lub Ecoclave.

Cawv tau zoo

Augmentin thiab cawv yog qhov kev xav tsis yog kev tawm tsam los ntawm cov cawv cawv ethyl tshuaj tua kab mobtsis pauv nws lub zog pharmacological.

Yog tias tawm tsam keeb kwm ntawm kev siv tshuaj yeeb muaj qhov xav kom haus dej haus cawv, nws yog ib qho tseem ceeb kom soj ntsuam ob yam kev mob: kev sim thiab maj nrawm.

Rau tib neeg kev txom nyem los ntawm kev quav dej cawv, kev siv yeeb tshuaj nrog cawv ib txhij tuaj yeem muaj kev phom sij loj dua.

Kev siv dej cawv hauv cov dej cawv ua rau cuam tshuam nrog ntau yam kev ntxhov siab hauv kev ua haujlwm mob siabCov. Cov neeg mob nrog tus neeg mob mob siab cov kev qhia pom zoo hais tias Augmentin yuav tsum muaj kev ceev faj heev, vim tias nws tau kwv yees tias yuav ua li cas lub cev muaj kabmob yuav coj tus cwj pwm hauv kev sim kom tiv thaiv. xenobioticnyuaj heev.

Yog li, yuav kom zam kev pheej hmoo tsis txaus ntseeg, nws raug nquahu kom tsis txhob haus cawv thaum lub sijhawm tag nrho ntawm kev kho nrog cov tshuaj.

Augmentin thaum cev xeeb tub thiab lactation

Zoo li feem ntau cov tshuaj tua kab mob penicillin pawg, amoxicillin, muab faib rau hauv cov ntaub so ntswg ntawm lub cev, tseem nkag rau hauv niam mis. Ntxiv mus, kab lus ntau yuav txawm pom nyob hauv mis. clavulanic acid.

Txawm li cas los xij, tsis muaj kev cuam tshuam loj hauv lub tsev kho mob los ntawm tus mob ntawm tus me nyuam yog sau tseg. Hauv qee kis, kev sib xyaw ua ke clavulanic acid nrog amoxicillin tuaj yeem tsim nyob rau hauv tus menyuam zawv plab thiab / lossis candidiasis (thrush) ntawm cov hnoos qeev hauv lub qhov ncauj kab noj hniav.

Augmentin belongs rau cov qeb ntawm cov tshuaj pub mis pub mis. Yog tias, txawm li cas los xij, tiv thaiv keeb kwm ntawm niam txoj kev kho mob nrog Augmentin, tus me nyuam muaj qee qhov tshwm sim tsis zoo, kev pub mis niam yog tso tseg.

Kev tshawb fawb tsiaj tau pom tias cov tshuaj nquag ntawm Augmentin muaj peev xwm nkag mus hematoplacental (GPB) teeb meemCov. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo rau kev loj hlob ntawm tus menyuam hauv plab.

Ntxiv mus, teratogenic teebmeem tau tsis tuaj nrog niam txiv kev coj noj coj ua thiab tshuaj noj ntawm qhov ncauj.

Kev siv cov Augmentin hauv cov poj niam cev xeeb tub tuaj yeem tuaj yeem coj mus rau kev loj hlob ntawm cov menyuam mos necrotizing enterocolitis (NEC).

Zoo li txhua lwm yam tshuaj, Augmentin tsis pom zoo rau cov poj niam cev xeeb tub. Thaum cev xeeb tub, nws siv tau rau qee qhov xwm txheej, raws li kws kho mob qhov kev ntsuas, qhov txiaj ntsig rau tus poj niam muaj ntau tshaj qhov txaus ntshai rau nws tus menyuam.

Kev txheeb xyuas txog Augmentin

Kev tshuaj xyuas ntawm cov ntsiav tshuaj thiab kev ncua rau cov me nyuam Augmentin rau feem ntau zooCov. Coob tus ntsuas cov tshuaj ua tshuaj tau txais txiaj ntsig zoo thiab ntseeg tau.

Ntawm cov chaw sib tham uas tib neeg qhia txog lawv cov kev xav ntawm qee yam tshuaj, cov qhab nia nruab nrab ntawm cov tshuaj tua kab mob yog 4,3-4.5 ntawm 5 lub ntsiab lus.

Cov kev tshuaj xyuas txog Augmentin tseg los ntawm leej niam ntawm cov menyuam yaus qhia tias cov cuab yeej pab tau daws sai sai nrog cov kab mob xws li mob thaum yau mob ntsws lossis mob caj pasCov. Ntxiv nrog rau qhov ua tau zoo ntawm cov tshuaj, cov niam kuj tseem nco qab nws cov qab ntxiag, uas cov menyuam nyiam.

Cov cuab yeej ua haujlwm kuj tseem muaj txiaj ntsig thaum cev xeeb tub. Txawm hais tias qhov tseeb hais tias qhov kev qhia tsis pom zoo kev kho mob nrog cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub sijhawm 1 lub sijhawm), Augmentin feem ntau yog txiav txim siab thib 2 thiab thib 3 txiav.

Raws li cov kws kho mob, qhov loj tshaj plaws thaum kho nrog cov cuab yeej no yog soj ntsuam qhov ntau npaum li cas thiab ua raws txhua qhov kev pom zoo ntawm koj tus kws kho mob.

Augmentin Nqe

Tus nqi ntawm Augmentin hauv Ukraine nws txawv nyob ntawm lub tsev muag tshuaj tshwj xeeb. Nyob rau tib lub sijhawm, tus nqi ntawm cov tshuaj yog me ntsis siab dua hauv cov khw muag tshuaj hauv Kiev, ntsiav tshuaj thiab kua txiv hauv cov chaw muag tshuaj hauv Donetsk, Odessa lossis Kharkov raug muag ntawm tus nqi me ntsis.

625 mg ntsiav tshuaj (500 mg / 125 mg) tau muag hauv khw muag tshuaj, ntawm thaj tsam, ntawm 83-85 UAH. Tus nqi nruab nrab ntawm Augmentin ntsiav tshuaj 875 mg / 125 mg - 125-135 UAH.

Koj tuaj yeem yuav cov tshuaj tua kab mob hauv cov hmoov ntawv rau kev npaj cov tshuaj rau kev txhaj tshuaj nrog qhov tshuaj ntawm 500 mg / 100 mg ntawm cov tshuaj yeeb dej caw, ntawm qhov nruab nrab, rau 218-225 UAH, tus nqi nruab nrab ntawm Augmentin 1000 mg / 200 mg - 330-354 UAH.

Nqe ntawm Augmentin kev ncua rau cov menyuam yaus:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Kev piav qhia ntawm daim ntawv tshuaj

Hmoov: dawb lossis yuav luag dawb, nrog tus yam ntxwv tsw. Thaum diluted, ib qho kev ncua ntawm dawb lossis yuav luag dawb yog tsim. Thaum sawv ntsug, ib qho dej dawb lossis dawb yuav luag nag lossis daus maj mam ua kom qeeb.

Ntsiav tshuaj, 250 mg + 125 mg: them nrog zaj duab xis membrane los ntawm dawb mus rau yuav luag dawb, kheej li lub qw hauv cov duab, nrog cov ntawv sau "AUGMENTIN" ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.

Ntsiav tshuaj, 500 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb hauv cov xim, oval, nrog cov ntawv sau extruded "AC" thiab txoj kev pheej hmoo ntawm ib sab.

Ntsiav tshuaj, 875 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb, kheej li lub qw, nrog cov tsiaj ntawv "A" thiab "C" ntawm ob sab thiab ib txoj kab txhaum ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.

Kev Taw Qhia Augmentin ®

Kev sib xyaw ntawm amoxicillin nrog clavulanic acid yog qhia rau kev kho mob ntawm cov kab mob ntawm cov chaw hauv qab no tshwm sim los ntawm cov kab mob me me nkag siab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid:

cov mob ua pa sab sauv (suav nrog rau tus mob ENT), xws li ua mob tonsillitis, mob ntsws, mob otitis, feem ntau tshwm sim Tus kab mob Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 thiab Streptococcus pyogenes, (tshwj tsis yog Augmentin ntsiav tshuaj 250 mg / 125 mg),

cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, mob ntsws mob ntsws, thiab mob ntsws, feem ntau tshwm sim Kab mob ntsws Streptococcus mob ntsws, Haemophilus khaub thuas 1 thiab Moraxella catarrhalis 1,

mob txeeb zig, xws li mob cystitis, tus mob urethritis, pyelonephritis, kis mob rau poj niam lub cev ua paug, feem ntau tshwm sim los ntawm hom tsiaj hauv tsev neeg Enterobacteriaceae 1 (feem ntau yog Escherichia coli 1 ), Dab Tsi Staphylococcus saprophyticus thiab hom Enterococcusli zoo li kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae 1,

daim tawv nqaij thiab cov nqaij mos muag kis mob feem ntau tshwm sim Staphylococcus aureus 1, Tus kab mob Streptococcus pyogenes thiab hom Bacteroides 1,

kis mob ntawm cov pob txha thiab pob qij txha, xws li osteomyelitis, feem ntau tshwm sim Staphylococcus aureus 1, yog tias tsim nyog, kho lub sijhawm ntev ntev yog qhov ua tau.

cov kab mob odontogenic, piv txwv li kab mob txha caj qaum, odontogenic maxillary sinusitis, mob hniav ntau heev nrog kev kis mob cellulitis (tsuas yog rau cov ntsiav tshuaj Augmentin cov ntawv, ntau npaum li 500 mg / 125 mg, 875 mg / 125 mg),

lwm cov kab mob sib xyaw (piv txwv, septic rho menyuam, tom qab sepsis, mob intraabdominal sepsis) yog ib feem ntawm kev kho mob kauj ruam (tsuas yog rau cov ntsiav tshuaj Augmentin ntau npaum 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Cov neeg sawv cev ntawm cov kab mob tsis txawv txav tsim cov beta-lactamase, uas ua rau lawv tsis raug tshuaj amoxicillin (saib. Pharmacodynamics).

Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag. Augmentin ® tseem qhia tau rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me uas tsim cov beta-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Cov kev nkag siab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av ntawd thiab sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.

Tsuas tshuaj thiab tswj hwm

Kev noj tshuaj rau lub cev yog tsim tshwj xeeb, nyob ntawm seb muaj hnub nyoog, hnyav lub cev, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav npaum li cas.

Txhawm rau kom txo qis lub plab zom mov tuaj yeem cuam tshuam thiab txhawm rau txhawm rau nqus kom zoo, cov tshuaj yuav tsum tau noj thaum pib noj mov. Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws yog qhov ua tau los ua cov kev kho mob stepwise (thawj kev tswj hwm kev siv tshuaj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Nws yuav tsum nco ntsoov tias 2 tab. Augmentin ®, 250 mg + 125 mg tsis sib npaug rau 1 ntsiav tshuaj. Augmentin ®, 500 mg + 125 mg.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos thiab laus dua lossis hnyav 40 kg lossis ntau dua. Nws raug nquahu kom siv 11 ml ntawm kev ncua ib ntus ntawm kev siv tshuaj ntawm 400 mg + 57 mg hauv 5 ml, uas yog sib npaug rau 1 lub rooj. Augmentin ®, 875 mg + 125 mg.

1 tab. 250 mg + 125 mg 3 zaug hauv ib hnub rau kev kis mob me me mus rau mob hnyav. Hauv kev kis mob hnyav (suav nrog mob ntsws thiab mob txeeb zig, mob ntsws thiab mob txawv txav ntawm txoj hlab ntsws), lwm txoj kev noj tshuaj ntawm Augmentin recommended raug pom zoo.

1 tab. 500 mg + 125 mg 3 zaug ib hnub.

1 tab. 875 mg + 125 mg 2 zaug ib hnub.

Cov menyuam hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua li 40 kg. Kev xam qhov tseeb yog nqa tawm raws li lub hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg / hnub lossis hauv ml ntawm kev ncua. Qhov koob tshuaj txhua hnub tau muab faib ua 3 koob tshuaj txhua 8 teev (125 mg + 31.25 mg) lossis 2 koob tshuaj txhua 12 teev (200 mg + 28.5 mg, 400 mg + 57 mg). Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.

Augmentin ® ntau npaum cov tshuaj (suav muab xam raws li amoxicillin)

Kev txhaj tshuaj qis ntawm Augmentin ® raug pom zoo rau kev kho mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau cov mob tonsillitis.

Kev txhaj tshuaj ntau ntawm Augmentin High raug pom zoo rau kev kho mob ntawm cov kab mob xws li otitis media, sinusitis, kis mob qis qis ntawm txoj hlab ntsws thiab mob txeeb zig, mob pob txha thiab pob qij txha.

Muaj cov ntaub ntawv tshawb fawb tsis txaus kom pom zoo siv cov tshuaj Augmentin ® hauv ib koob ntau dua 40 mg + 10 mg / kg hauv 3 koob tshuaj (4: 1 ncua kev kawm) rau cov menyuam yaus hnub nyoog qis dua 2 xyoos.

Cov menyuam txij thaum yug mus txog 3 hlis. Vim lub cev tsis muaj nuj nqi ntawm qhov muaj nuj nqi zoo kawg ntawm lub raum, qhov tshuaj pom zoo ntawm Augmentin ® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.

Cov menyuam yug ntxov ntxov. Tsis muaj cov lus qhia hais txog qhov muab tshuaj.

Cov pab pawg neeg tshwj xeeb

Cov neeg laus cov neeg mob. Kev kho ntawm cov tshuaj ntau npaum li cas tsis tas yuav tsum tau ua; Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, cov koob tshuaj uas tsim nyog rau cov neeg laus uas lub raum tsis ua haujlwm.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los hloov lub tswv yim hloov cov koob tshuaj hauv cov neeg mob zoo li no.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Kev kho ntawm cov tshuaj ntau npaum li cas yog raws li qhov siab tshaj plaws kev pom zoo ntawm amoxicillin thiab creatinine tshem tawm tus nqi.

Augmentin age ntau npaum kev noj tshuaj

Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg: Cov koob tshuaj hloov kho raws li qhov xav tau ntau tshaj plaws ntawm amoxicillin.

2 tab. 250 mg + 125 mg hauv 1 koob tshuaj txhua 24 teev

Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (1 ntsiav tshuaj) thiab lwm 1 lub tshuaj. tom kawg ntawm kev lim ntshav lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg: Cov koob tshuaj hloov kho raws li qhov xav tau ntau tshaj plaws ntawm amoxicillin.

1 tab. 500 mg + 125 mg hauv 1 koob tshuaj txhua 24 teev

Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (1 ntsiav tshuaj) thiab lwm 1 lub tshuaj. tom kawg ntawm kev lim ntshav lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Tus txheej txheem ntawm kev npaj ntawm qhov raug ncua

Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug. Kwv yees li 60 ml ntawm cov dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, cia lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Feem ntau, txog 92 ml dej yuav tsum npaj los txhawm rau ncua dej kom ntau li 125 mg + 31.25 mg thiab 64 ml dej rau kom haus 200 mg + 28.5 mg thiab 400 mg + 57 mg.

Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov kev ncua ntawm kev siv tshuaj Augmentin ® tuaj yeem tov nrog dej hauv qhov sib piv ntawm 1: 1.

Daim ntawv tso tawm

Qhov ncauj ntsiav tshuaj - 14 daim ib pob

Pharmacological kev txiav txim

Ua ke nrog cov tshuaj tiv thaiv kom dav-tiv thaiv kev tiv thaiv to-lactamase uas muaj amoxicillin thiab clavulanic acid.

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Nyob rau tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm β-lactamases, thiab yog li ntawd kev ua si spectrum ntawm amoxicillin tsis txuas ntxiv rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, ib qho β-lactamase inhibitor yam ntxwv ntawm kev siv rau penicillins, muaj peev xwm tsis muaj peev xwm tiv thaiv ntau yam ntawm β-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin resistant microorganisms.

Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid β-lactamases, uas feem ntau ua rau cov kab mob tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv chromosomal β-lactamases ntawm hom 1 uas tsis tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob hauv kev npaj Augmentin CP tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - act-lactamases, uas tso cai nthuav tawm cov tshuaj tua kab mob ntawm amoxicillin.

Kev taw qhia rau kev siv

Cov kab mob kis tau los ntawm cov tshuaj lom neeg lub cev:

• kev kis mob ntawm cov mob ua pa sab saud thiab ENT kabmob (piv txwv li tonsillitis, sinusitis, otitis media), feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes,
• cov kab mob ua pa tsawg dua: exacerbations ntawm mob ntsws ntev, lobar mob ntsws thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae thiab Moraxella catarrhalis (tshwj tsis yog ntsiav tshuaj 250 mg / 125 mg),
• mob txeeb zig: cystitis, urethritis, pyelonephritis, kis mob rau poj niam lub cev, ua feem ntau los ntawm hom kab mob Enterobacteriaceae (feem ntau Escherichia coli *), Staphylococcus saprophyticus thiab hom kab mob ntawm genus Enterococcus,
• kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae (tshwj tsis yog 250 mg / 125 mg ntsiav tshuaj),
• kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus, Streptococcus pyogenes thiab hom ntawm lub genus Bactero> Kev Siv Tshuaj thiab kev tswj hwm

Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.

Txhawm rau kom zoo thiab txo qis kev phiv los ntawm lub plab zom mov, Augmentin raug pom zoo kom noj thaum pib noj mov.

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Cov Yuav Tsum Muaj

• cov tshuaj tiv thaiv tsis haum rau amoxicillin, clavulanic acid, lwm yam tshuaj, tshuaj tua kab mob beta-lactam (piv txwv li penicillins, cephalosporins) hauv anamnesis,
• yav dhau los lub sijhawm daj ntseg lossis lub siab ua kom lub siab ua haujlwm thaum siv amoxicillin nrog clavulanic acid hauv keeb kwm
• cov me nyuam qis dua 12 xyoos thiab lub cev hnyav dua 40 kg

Cia rau cov neeg mob

Cov tshuaj yuav tsum muab khaws cia kom deb ntawm qhov ncav cuag ntawm cov menyuam ntawm qhov kub tsis tshaj li 25 ° C.

Hauv ib qhov ncauj ntsiav tshuaj muaj 0.25, 0.5 lossis 0.875 g amoxicillin trihydrate thiab 0.125 g clavulanic acid (hauv kev tsim cov tshuaj, clavulanate sodium yog tso nrog 5% ntau dhau).

Hauv tshuaj ntsiav ntu ntu: Silicii dioxideydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Ib fwj hmoov rau kev npaj daws rau kev txhaj tshuaj muaj 0.5 lossis 1 g amoxicillin trihydrate thiab, feem, 0.1 lossis 0.2 g clavulanic acid.

Cov muaj pes tsawg leeg Augmentin hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj suav nrog 0.125 / 0.2 / 0.4 g (5 ml) amoxicillin trihydrate thiab, feem, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Xanthan ntawm cov pos hniav, Hydroxypropyl methylcellulose, Silicii dioxideydum colloidale, Acidum succinicum, Silicii dioxideydum, Aspartamum (E951), qhuav - txiv kab ntxwv tsw qab (610271E thiab 9/027108), txiv pos thiab "Bright molasses".

Hauv hmoov Augmentin EU npaj rau kev npaj ntawm 100 ml ntawm kev ncuamuaj 0.6 g (5 ml) amoxicillin trihydrate thiab 0.0429 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Silicii dioxideydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan ntawm cov pos hniav, Silicii Dydydum, tsw tsw qab 544428.

Hauv qhov muaj pes tsawg leeg ntawm ib qho Augmentin CP ntsiav tshuaj nrog rau kev ua ntev nrog rau 1 g amoxicillin trihydrate thiab 0.0625 g clavulanic acid.

Ntu Cheebtsam: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxideydum colloidale, Magnesium stearate, Xanthan ntawm cov pos hniav, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum

Cov tshuaj muaj daim ntawv tso tawm hauv qab no:

• Augmentin ntsiav tshuaj 250 mg + 125 mg, Augmentin 500 mg + 125 mg thiab Augmentin 875 + 125 mg.
• Hmoov 500/100 mg thiab 1000/200 mg, npaj rau kev npaj ntawm kev daws rau kev txhaj tshuaj.
• Hmoov rau kev ncua ncua Augmentin 400 mg / 57 mg, 200 mg / 28.5 mg, 125 mg / 31.25 mg.
• Hmoov Augmentin EU 600 mg / 42.9 mg (5 ml) rau kev ncua.
• Augmentin CP 1000 mg / 62.5 mg txhawb cov ntsiav tshuaj tso tawm

Augmentin belongs rau cov pab pawg muab tshuaj kho mob "Cov tshuaj tua kab mob rau kev siv kab ke. -lactams. Penicillins. "

Cov nyhuv pharmacological ntawm cov tshuaj yog Tshuaj tua kab mob thiab tua kab mob.

Pharmacodynamics thiab pharmacokinetics

Raws li Wikipedia, Amoxicillin yog cov kab mob bactericidalzoo tiv thaiv ntau yam kab mob thiab cov kab mob muaj peev xwm cov kab mob me me thiab sawv cev semisynthetic penicillin pawg tshuaj tiv thaiv.

Txhawb pab transpeptidase thiab cuam tshuam nrog kev tsim khoom mureina (qhov tseem ceeb tshaj plaws ntawm cov phab ntsa ntawm cov kab mob hauv lub cev) thaum lub sijhawm faib thiab kev loj hlob, nws provokes li lysis (kev rhuav tshem) cov kab mob.

Amoxicillin raug rhuav tshem -lactamasesyog li nws cov kev ua haujlwm tiv thaiv kab mob tsis txuas ntxiv cov kab mob me metsim khoom -lactamases.

Ua raws li kev sib tw thiab nyob rau hauv feem ntau ntawm ib tug tsis tuaj yeem inhibitor, clavulanic acid tsiag ntawv los ntawm kev muaj peev xwm txeem ntxeem phab ntsa cov kab mob thiab ua rau inactivation cov enzymesuas muaj nyob ntawm ob sab ntawm tes thiab ntawm nws cov ciam teb.

Clavulanate cov ntaub ntawv ruaj khov inactivated complexes nrog -lactamasesthiab no nyeg tiv thaiv kev puas tsuaj amoxicillin.

Augmentin tshuaj tua kab mob zoo tiv thaiv:

• Nyiaj Gram (+) aerobes: pyogenic mob streptococcus pawg A thiab B, pneumococci, Staphylococcus aureus thiab mob sab nrauv, (tshwj tsis yog zam ntawm kab mob methicillin-tiv taus lim tawm), saprophytic staphylococcus thiab lwm tus
• Nyiaj Gram (-) aerobes: Pfeiffer nrog, mob hnoos hawb pob, gardnerella vaginalis , Mob raws plab lwm yam.
• Gram (+) thiab Gram (-) ntawm anaerobes: bacteroids, fusobacteria, preotellas lwm yam.
• Lwm yam kab mob me me: mob chlamydia, spirochete, daj ntseg treponema lwm yam.

Tom qab kev siv cov tshuaj Augmentin, ob qho ntawm nws lub cev ua kom nrawm nrawm thiab nqus tawm ntawm qhov hnyuv. Kev nqus tau yog qhov zoo dua yog tias ntsiav tshuaj lossis kua dej cawv thaum noj mov (thaum pib noj mov).

Ob qho tib si thaum noj ntawm qhov ncauj, thiab nrog cov lus qhia ntawm Augmentin IV kev daws teeb meem, kev kho tshuaj ntau ntawm cov tshuaj ua kom muaj zog nyob hauv txhua cov ntaub so ntswg thiab cov kua dej ua kua interstitial.

Ob leeg lub zog ua kom tsis muaj zog khi rau ntshav ntshav protein (txog 25% khi rau cov ntshav protein amoxicillin trihydrate thiab tsis ntau tshaj 18% clavulanic acid) Tsis muaj qhov mus ntxiv ntawm Augmentin raug kuaj pom ib qho ntawm cov kabmob hauv nruab nrog.

Amoxicillin nphav raug kev zom mov nyob rau hauv lub cev thiab excreted ob lub raumlos ntawm kev zom cov pa zom zaws thiab hauv daim ntawv cov roj carbon dioxide nrog rau cov pa tawm kom zoo. 10 txog 25% ntawm qhov koob tau txais amoxicillin raug zam ob lub raum hauv daim ntawv penicilloic aciduas yog nws tsis tsaug zog metabolite.

Clavulanate raug tawm ob leeg los ntawm lub raum thiab los ntawm txoj kev ua cov txheej txheem ntxiv.

Kev ntsuas rau siv

Kev taw qhia rau kev siv ntawm kev sib xyaw amoxicillin trihydrate thiab clavulanic acid yog kis tau tus mobprovoked los ntawm rhiab rau qhov kev txiav txim ntawm cov tshuaj no cov kab mob me me.

Kev kho mob Augmentin tseem raug tso cai. kis tau tus mobtshwm sim los ntawm kev ua si cov kab mob me merhiab rau kev txiav txim amoxicillinthiab li sib xyaw kis tau tus mobprovoked los ntawm rhiab rau cov kab mob amoxicillin thiab cov kab mob uas tsim tawm -lactamase thiab raug cim los ntawm rhiab xav rau kev sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Hauv Is Taws Nem, cov lus nug feem ntau nug “Cov ntsiav tshuaj Augmentin yog los ntawm dab tsi? "Los sis" Augmentin Syrup Curing yog dab tsi? ".

Kev thaj tsam ntawm cov tshuaj no nws kim heev. Nws yog tshuaj rau hauv qab no kab mob sib kis thiab kab mob:

• ntawm kis tau tus mobcuam ​​tshuam qaum thiab qis cov pa ua pa (suav nrog suav nrog Cov mob ENT),
• ntawm kis tau tus mobcuam ​​tshuam genitourinary huam,
• ntawm odontogenic (mob hauv qhov ncauj) mob,
• ntawm cov kab mob gynecological,
• ntawm gonorrhea,
• ntawm kis tau tus mobcuam ​​tshuam daim tawv nqaij thiab cov nqaij mos,
• ntawm kis tau tus mobcuam ​​tshuam nqaij pob txha (suav nrog yog tias tsim nyog, kev teem sij hawm ntawm kev kho mob mus ntev rau tus neeg mob),
• lwm yam kis tau tus mob hom sib xyaw (piv txwv li tom qab septic rho menyuamntawm sepsis nyob rau lub sijhawm ua haujlwm tom qab yug menyuam tas, nrog septicemia (sepsis tsis muaj metastases), mob peritonitisntawm sepsistshwm sim los ntawm kev kis tus mob intraabdominalntawm kis tau tus mobtsim tom qab kev phais mob).

Augmentin feem ntau yog siv los tiv thaiv kev ntsuas ua ntej ua cov kev phais loj rau kev ua haujlwm taub hau, caj dab, lub plab zom mov, lub raum, mob plab, ntawm cov kabmob uas nyob hauv plab hu ua pelvic.thiab raws li thaum lub sij hawm tus txheej txheem cog cov khoom hauv nruab nrog cev.

Augmentin nyob rau hauv txhua daim ntawv qhia cov tshuaj yog contraindicated:

• cov neeg mob uas lub siab tsis haum rau ib lossis ob qho kev sib txuas ntawm cov tshuaj, rau ib qho ntawm nws qhov kev tshem tawm, ntxiv rau -lactam (i.e. to tshuaj tua kab mob los ntawm tej pab pawg tshuaj penicillin thiab cephalosporin),
• cov neeg mob uas tau ntsib kev kho mob ntawm Augmentin kho mob dajntoo lossis keeb kwm ntawm qhov tsis taus zoo mob siab vim kev siv tshuaj sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Ib qho kev tiv thaiv ntxiv rau kev teem caij ua hmoov rau kev npaj ntawm qhov ncauj tshem tawm nrog qhov ntau npaum ntawm cov tshuaj dej ntawm 125 + 31.25 mg yog PKU (phenylketonuria).

Lub hmoov siv rau kev npaj ntawm qhov ncauj ncua nrog qhov ntau npaum ntawm cov tshuaj dej (200 + 28.5) thiab (400 + 57) mg yog contraindicated:

• ntawm PKU,
• cov neeg mob uas tsis taus raumntawm qhov ntsuas Reberg kev ntsuam xyuas hauv qab no 30 ml ib feeb
• cov menyuam yaus hnub nyoog qis dua 3 hlis.

Ib qho kev tiv thaiv ntxiv rau kev siv cov ntsiav tshuaj nrog cov tshuaj ntau dua (250 + 125) thiab (500 + 125) mg yog lub hnub nyoog qis dua 12 xyoos thiab / lossis hnyav dua 40 phaus.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm cov tshuaj nquag 875 + 125 mg yog contraindicated:

• ua txhaum txoj haujlwm kev ua haujlwm raum (ntsuas Reberg kev ntsuam xyuas hauv qab 30 ml ib feeb)
• cov me nyuam qis dua 12 xyoos
• cov neeg mob uas lub cev tsis hnyav tshaj 40 kg.

Kev phiv los ntawm Augmentin tuaj yeem tshwm sim los ntawm ntau lub tshuab thiab ib tus kabmob.Feem ntau cov feem ntau, tiv thaiv keeb kwm ntawm kev siv tshuaj kho yeeb tshuaj, cov kev coj ua hauv qab no tuaj yeem pom:

• candidiasis (pom quav) ntawm daim tawv nqaij thiab mucous daim nyias nyias,
• zawv plab (ntau zaus - thaum noj Augmentin hauv cov ntsiav tshuaj, feem ntau thaum noj ncua lossis txhaj tshuaj),
• bouts ntawm xeev siab thiab ntuav (xeev siab feem ntau tshwm sim thaum noj cov tshuaj hauv qhov siab).

Tej kev phiv uas tshwm sim muaj xws li:

• kiv taub hau,
• mob taub hau,
• dysfunctions kev zom plab,
• nce ntxiv hauv daim siab enzyme ua si alanine transaminases (ALT) thiab kev hloov chaw aspartate (AST),
• daim tawv nqaij ua pob, khaus tawvqhov kev tshwm sim urticaria.

Tsawg zaus, lub cev tuaj yeem teb rau kev txais tos ntawm Augmentin:

• thim rov qab leukopenia (suav nrog suav nrog agranulocytosis),
  thrombocytopenia,
• kev txhim kho thrombophlebitis ntawm qhov chaw txhaj tshuaj
• polymorphic erythema.

Tsis tshua muaj neeg tuaj yeem txhim kho:

• hemolytic anemia,
• tej yam kev mob uas pom los ntawm kev nce hauv lub sijhawm los ntshav thiab nce ntxiv prothrombin Performance index,
• kev tawm tsam los ntawm lub cev tiv thaiv kab mobuas qhia raws li angioedema, ib qho syndrome zoo ib yam li qhov tshwm sim hauv ntshiab ntshav mob, anaphylaxis, ua xua vasculitis,
• hyperactivity hom reversible
• nce pom kev ua si,
• tus kausvim kev txais tos tshuaj tua kab mobsuav nrog suav nrog pseudomembranous (PMK) thiab hemorrhagic (qhov ntxim nyiam ntawm kev txhim kho tom kawg poob qis yog tias Augmentin raug tswj hwm los ntawm niam txiv),
• keratinization thiab kev loj hlob ntawm tus nplaig zoo li tus papillae nyob ntawm tus nplaig (kab mob hu ua “tus nplaig plaub hau dub”),
• kab mob siab thiab mob siab cholestasis,
• Lyell cov tsos mob,
• feem ntau exanthematous pustulosis nyob rau hauv daim ntawv mob
• interstitial nephritis,
• cov tsos hauv cov zis ntawm ntsev muaju (crystalluria).

Thaum muaj dermatitis kev ua xua kev kho mob Augmentin yuav tsum tsis ua mus ntxiv.

Cov lus qhia rau kev siv Augmentin: txoj kev thov, ntau npaum li cas rau cov neeg laus thiab menyuam yaus

Ib qho ntawm cov lus nug feem ntau ntawm tus neeg mob yog cov lus nug txog kev noj tshuaj ua ntej lossis tom qab noj mov. Nyob rau hauv rooj plaub ntawm Augmentin, kev noj tshuaj yog ze ze rau kev noj mov. Nws yog suav hais tias yog qhov zoo tshaj rau noj cov tshuaj ncaj qha. ua ntej noj mov.

Ua ntej, nws muab kev nqus zoo dua ntawm lawv cov tshuaj nquag Kev kho mob txoj hnyuv, thiab, ob, nws tuaj yeem txo qhov hnyav Mob plab zom mov tsis haum ntawm lub plab zom movyog tom kawg ntawv xwb.

Yuav ua li cas los xam cov koob tshuaj ntawm Augmentin

Yuav ua li cas noj cov tshuaj Augmentin rau cov neeg laus thiab menyuam yaus, nrog rau nws txoj kev kho kom haum, nyob ntawm seb qhov twg microorganism yog ib tug kab mob, kev rhiab npaum li cas yog nws raug tshuaj tua kab mob, qhov mob hnyav thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob, kev ua kom pom ntawm thaj chaw sib kis, lub hnub nyoog thiab qhov hnyav ntawm tus neeg mob, nrog rau nws noj qab haus huv npaum li cas ob lub raum tus neeg mob.

Lub sijhawm tiv thaiv ntawm cov chav kho yog nyob ntawm seb tus neeg mob lub cev teb li cas rau kev kho mob.

Augmentin ntsiav tshuaj: cov lus qhia rau kev siv

Ua raws li cov ntsiab lus ntawm cov tshuaj yeeb dej caw hauv lawv, Augmentin ntsiav tshuaj raug pom zoo rau cov neeg mob laus kom noj raws li cov qauv hauv qab no:

• Augmentin 375 mg (250 mg + 125 mg) - ib peb zaug ib hnub. Hauv kev siv ntau npaum li cas, cov tshuaj tau qhia rau kis tau tus mobuas ntws hauv yooj yim lossis tsim nyog me. Thaum muaj mob hnyav, suav nrog mob ntev thiab rov tshwm sim, ntau dua qhov tau muab tshuaj.
• Cov ntsiav tshuaj 625 mg (500 mg + 125 mg) - ib peb zaug ib hnub.
• 1000 mg ntsiav tshuaj (875 mg + 125 mg) - ib hnub ob zaug.

Qhov hno yog raug rau kev kho rau cov neeg mob uas tsis muaj lub luag haujlwm. raum.

Augmentin CP 1000 mg / 62.5 mg cia cov ntsiav tshuaj tso tawm tsuas yog pub rau cov neeg mob hnub nyoog 16 xyoo rov hauv. Cov koob tshuaj zoo yog ob ntsiav tshuaj ib hnub ob zaug.

Yog tias tus neeg mob tsis tuaj yeem nqos tag nrho cov ntsiav tshuaj, nws muab faib ua ob kab raws txoj kab txhaum. Ob qho tib si ob leeg tau coj tib lub sijhawm.

Cov neeg mob nrog rau cov neeg mob ob lub raum cov tshuaj yog kws kho tsuas yog hauv qhov xwm txheej ntawm qhov ntsuas Reberg kev ntsuam xyuas ntau tshaj 30 ml tauj ib feeb (uas yog, thaum kho kom haum rau qhov tshuaj ntau npaum li cas tsis tas yuav).

Hmoov rau cov tshuaj rau kev txhaj tshuaj: cov lus qhia rau kev siv

Raws li cov lus qhia, txoj kev daws teeb meem yog txhaj rau hauv txoj leeg: los ntawm dav hlau (qhov koob tshuaj yuav tsum tau txhaj tshuaj hauv 3-4 feeb) lossis los ntawm cov txheej txheem dej (lub sijhawm ntawm Txoj kev lis ntshav yog los ntawm ib nrab ntawm ib teev mus rau 40 feeb). Txoj kev daws tsis tau xav kom tau txhaj tshuaj rau hauv cov leeg.

Cov qauv muab rau ib tus neeg mob laus yog 1000 mg / 200 mg. Nws raug nquahu kom nkag nws txhua yim teev, thiab rau cov uas muaj teeb meem kis tau tus mob - txhua rau lossis rau plaub teev (raws li qhia).

Tshuaj tua kab mob hauv kev txiav txim siab ntawm tshuaj, 500 mg / 100 mg lossis 1000 mg / 200 mg yog tau sau tseg rau kev tiv thaiv kev txhim kho kis mob tom qab phais tasCov. Hauv kis uas lub sijhawm ua haujlwm tsawg dua li ib teev, nws txaus rau nkag mus rau tus neeg mob ib zaug ua ntej Tshuaj loog koob tshuaj ntawm Augmentin 1000 mg / 200 mg.

Yog tias nws cia siab tias qhov kev ua haujlwm yuav kav ntev dua li ib teev, txog plaub koob ntawm 1000 mg / 200 mg tau muab rau tus neeg mob nyob rau hnub dhau los rau 24 teev.

Kev ncua Augmentin: cov lus qhia rau kev siv

Cov lus qhia rau kev siv Augmentin rau menyuam yaus pom zoo kom teem sij hawm ncua ntawm 125 mg / 31.25 mg hauv koob tshuaj 2.5 txog 20 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 3 thaum nruab hnub. Qhov ntim ntawm ib koob tshuaj nyob ntawm lub hnub nyoog thiab qhov hnyav ntawm tus menyuam.

Yog tias tus menyuam loj dua ob lub hlis ntawm hnub nyoog, ncua kev ncua 200 mg / 28.5 mg yog tau sau rau hauv koob tshuaj ib yam li 25 / 3.6 mg rau 45 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav. Cov koob tshuaj uas tau hais tseg yuav tsum muab faib ua ob zaug.

Qhov ncua kev kawm ntawv nrog rau qhov ntau npaum ntawm cov tshuaj 400 mg / 57 mg (Augmentin 2) yog qhia rau kev siv pib txij li xyoo. Nyob ntawm seb tus me nyuam muaj hnub nyoog thiab hnyav li cas, ib koob tshuaj nws txawv ntawm 5 mus rau 10 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 2 thaum nruab hnub.

Augmentin EU yog pib txij 3 lub hlis hnub nyoog. Cov koob tshuaj zoo tshaj plaws yog 90 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub (qhov koob tshuaj yuav tsum tau muab faib ua 2 koob, khaws ib ntu 12-teev nruab nrab ntawm lawv).

Niaj hnub no, cov tshuaj hauv ntau hom tshuaj yog ib qho ntawm cov tshuaj tshaj plaws rau kev kho mob. mob qa.

Cov me nyuam Augmentin nrog mob caj pas sau rau hauv lub koob tshuaj uas tau txiav txim siab raws lub cev qhov hnyav thiab hnub nyoog ntawm tus menyuam. Nrog angina rau cov neeg laus, nws raug nquahu kom siv Augmentin 875 + 125 mg peb zaug ib hnub.

Tsis tas li, lawv feem ntau yog mus rau lub sijhawm Augmentin mob hlab ntswsCov. Txoj kev kho yog ntxiv los ntawm kev ntxuav lub qhov ntswg nrog ntsev hiav txwv thiab siv tshuaj txau qhov ntswg ntawm hom RinofluimucilCov. Koob tshuaj zoo rau mob hlab ntsws: 875/125 mg 2 zaug ib hnub. Lub sijhawm ua haujlwm ntawm feem ntau yog 7 hnub.

Tshaj dhau qhov koob ntawm Augmentin tau nrog los ntawm:

• kev txhim kho ntawm kev ua txhaum los ntawm cov hnyuv,
• ua txhaum ntawm dej-ntsev tshuav,
• crystalluria,
• lub raum tsis ua hauj lwm,
• nag lossis daus (nag lossis daus) ntawm amoxicillin nyob rau hauv lub raj tso zis.

Thaum cov tsos mob zoo li no tshwm sim, tus neeg mob tau qhia pom muaj kev kho mob, nrog rau, ntawm lwm yam, kev kho ntawm cov dej-ntsev kom sib npaug. Thim ntawm Augmentin los ntawm rauequilibrium system kuj pab txhawb tus txheej txheem hemodialysis.

Yuam kev tswj fwm cov tshuaj nrog probenecid:

• pab txo kom tsawg tubular zais cia ntawm amoxicillin,
• provokes ib qho kev nce nyob rau hauv concentration amoxicillin hauv ntshav ntshav (cov nyhuv cuam tshuam ntev mus),
• tsis cuam tshuam rau cov khoom thiab theem ntawm cov ntsiab lus hauv clavulanic acid ntshav ntshav.

Sib txuam ua ke amoxicillin nrog allopurinol nce txoj kev nyiam qhov zuj zus ua xuaCov. Cov ntaub ntawv sib cuam tshuam allopurinol ib txhij nrog ob qho kev nquag ntawm Augmentan tsis tuaj.

Augmentin muaj cov nyhuv hauv uas muaj nyob hauv txoj hnyuv microflorauas provokes ib tug txo nyob rau hauv reabsorption (thim rov qab haum) tshuaj estrogen, nrog rau kev txo qis hauv cov txiaj ntsig ntawm kev sib xyaw ua ke tshuaj tiv thaiv rau kev siv qhov ncauj.

Cov tshuaj tsis sib xws nrog cov ntshav cov ntshav thiab cov kua-muaj kua, nrog rau suav nrog whey protein hydrolysates thiab roj emulsions npaj rau kev ntxig rau hauv cov leeg ntshav.

Yog tias Augmentin tawm tshuaj nrog rau tshuaj tua kab mob chav kawm aminoglycosides, cov tshuaj tsis sib xyaw rau hauv ib lub koob txhaj tshuaj lossis lwm lub thauv tshuaj ua ntej kev tswj hwm, vim tias qhov no ua rau tsis muaj zog aminoglycosides.

Kev npaj cov khoom ntim thaum xub thawj yog khaws cia ntawm qhov kub uas tsis tshaj 25 ° C. Qhov tshem tawm yuav tsum khaws cia ntawm qhov kub ntawm 2-8 ° C (zoo tshaj hauv tub yees) tsis pub ntev tshaj 7 hnub.

Nws tsim nyog siv nyob rau hauv 2 xyoos txij li hnub ntawm kev tsim khoom lag luam.

Cov Lus Qhia Txog AugmentinCov kev sib tw rau ATX Qib 4 code:

Augmentin analogs yog cov tshuaj A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

Txhua ntawm cov tshuaj saum toj no yog dab tsi Augmentin tuaj yeem hloov pauv hauv nws qhov tsis tuaj.

Tus nqi ntawm cov khoom tsis txawv txav los ntawm 63.65 txog 333.97 UAH.

Augmentin rau menyuam yaus

Augmentin siv dav hauv kev xyaum tsiaj txhu. Vim qhov tseeb tias nws muaj menyuam yaus daim ntawv tso tawm - kua phoov, nws tuaj yeem siv tau los kho menyuam yaus rau ib xyoos xwb. Kev teeb tsa tshwj xeeb ua rau txais tos thiab qhov tseeb hais tias cov tshuaj muaj cov khoom qab ntxiag.

Rau menyuam tshuaj tua kab mob feem ntau kho mob rau mob caj pasCov. Qhov ntau npaum li cas ntawm kev ncua rau cov me nyuam yog txiav txim siab los ntawm lub hnub nyoog thiab qhov hnyav. Cov koob tshuaj zoo tshaj plaws tau muab faib ua ob koob, sib npaug 45 mg / kg ib hnub, lossis faib ua peb koob, koob tshuaj 40 mg / kg ib hnub.

Kev siv cov tshuaj rau cov menyuam yaus thiab caij nyoog ntau npaum li cas yog nyob ntawm daim ntawv ntau npaum li cas.

Rau cov menyuam yaus lub cev qhov hnyav tshaj 40 kg, Augmentin raug tso cai tib yam li cov neeg laus.

Augmentin phoov rau cov menyuam yaus txog li ib xyoos yog siv hauv qhov ntau ntawm 125 mg / 31.25 mg thiab 200 mg / 28.5 mg. Kev noj tshuaj ntawm 400 mg / 57 mg yog qhia rau cov menyuam yaus tshaj ib xyoos.

Cov menyuam yaus nyob rau hauv hnub nyoog 6-12 xyoo (hnyav dua 19 kg) raug tso cai siv ob qho kev ncua lossis Augmentin hauv cov ntsiav tshuaj. Kev muab tshuaj ntawm lub ntsiav tshuaj daim ntawv tshuaj yog raws li nram no:

• ib ntsiav tshuaj 250 mg + 125 mg peb zaug ib hnub,
• ib ntsiav tshuaj 500 + 125 mg ob zaug ib hnub (daim ntawv teev ntau npaum li no yog txoj kev pom zoo).

Cov menyuam yaus hnub nyoog dhau 12 xyoos raug samfwm kom noj ib ntsiav tshuaj ntawm 875 mg + 125 mg ob zaug ib hnub.

Txhawm rau kom ntsuas qhov tseeb ntawm koob tshuaj Augmentin kev ncua rau cov menyuam muaj hnub nyoog qis dua 3 hlis, nws pom zoo kom ntaus cov lej nrog ib rab koob uas muaj qhov cim. Txhawm rau kom siv txoj kev siv ncua kev kawm ntawv hauv cov menyuam yaus hauv qab ob xyoos, nws tau tso cai kom cov kua dej nrog cov dej hauv qhov piv rau 50/50

Augmentin's analogues, uas yog nws txoj kev hloov pauv chaw muag tshuaj, yog cov tshuaj Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Lub Ecoclave.

Cawv tau zoo

Augmentin thiab cawv yog qhov kev xav tsis yog kev tawm tsam los ntawm cov cawv cawv ethyl tshuaj tua kab mob tsis pauv nws lub zog pharmacological.

Yog tias tawm tsam keeb kwm ntawm kev siv tshuaj yeeb muaj qhov xav kom haus dej haus cawv, nws yog ib qho tseem ceeb kom soj ntsuam ob yam kev mob: kev sim thiab maj nrawm.

Rau tib neeg kev txom nyem los ntawm kev quav dej cawv, kev siv yeeb tshuaj nrog cawv ib txhij tuaj yeem muaj kev phom sij loj dua.

Kev siv dej cawv hauv cov dej cawv ua rau cuam tshuam nrog ntau yam kev ntxhov siab hauv kev ua haujlwm mob siabCov. Cov neeg mob nrog tus neeg mob mob siab cov kev qhia pom zoo hais tias Augmentin yuav tsum muaj kev ceev faj heev, vim tias nws tau kwv yees tias yuav ua li cas lub cev muaj kabmob yuav coj tus cwj pwm hauv kev sim kom tiv thaiv. xenobioticnyuaj heev.

Yog li, yuav kom zam kev pheej hmoo tsis txaus ntseeg, nws raug nquahu kom tsis txhob haus cawv thaum lub sijhawm tag nrho ntawm kev kho nrog cov tshuaj.

Augmentin thaum cev xeeb tub thiab lactation

Zoo li feem ntau cov tshuaj tua kab mob penicillin pawg, amoxicillin, muab faib rau hauv cov ntaub so ntswg ntawm lub cev, tseem nkag rau hauv niam mis.Ntxiv mus, kab lus ntau yuav txawm pom nyob hauv mis. clavulanic acid.

Txawm li cas los xij, tsis muaj kev cuam tshuam loj hauv lub tsev kho mob los ntawm tus mob ntawm tus me nyuam yog sau tseg. Hauv qee kis, kev sib xyaw ua ke clavulanic acid nrog amoxicillin tuaj yeem tsim nyob rau hauv tus menyuam zawv plab thiab / lossis candidiasis (thrush) ntawm cov hnoos qeev hauv lub qhov ncauj kab noj hniav.

Augmentin belongs rau cov qeb ntawm cov tshuaj pub mis pub mis. Yog tias, txawm li cas los xij, tiv thaiv keeb kwm ntawm niam txoj kev kho mob nrog Augmentin, tus me nyuam muaj qee qhov tshwm sim tsis zoo, kev pub mis niam yog tso tseg.

Kev tshawb fawb tsiaj tau pom tias cov tshuaj nquag ntawm Augmentin muaj peev xwm nkag mus hematoplacental (GPB) teeb meemCov. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo rau kev loj hlob ntawm tus menyuam hauv plab.

Ntxiv mus, teratogenic teebmeem tau tsis tuaj nrog niam txiv kev coj noj coj ua thiab tshuaj noj ntawm qhov ncauj.

Kev siv cov Augmentin hauv cov poj niam cev xeeb tub tuaj yeem tuaj yeem coj mus rau kev loj hlob ntawm cov menyuam mos necrotizing enterocolitis (NEC).

Zoo li txhua lwm yam tshuaj, Augmentin tsis pom zoo rau cov poj niam cev xeeb tub. Thaum cev xeeb tub, nws siv tau rau qee qhov xwm txheej, raws li kws kho mob qhov kev ntsuas, qhov txiaj ntsig rau tus poj niam muaj ntau tshaj qhov txaus ntshai rau nws tus menyuam.

Kev txheeb xyuas txog Augmentin

Kev tshuaj xyuas ntawm cov ntsiav tshuaj thiab kev ncua rau cov me nyuam Augmentin rau feem ntau zooCov. Coob tus ntsuas cov tshuaj ua tshuaj tau txais txiaj ntsig zoo thiab ntseeg tau.

Ntawm cov chaw sib tham uas tib neeg qhia txog lawv cov kev xav ntawm qee yam tshuaj, cov qhab nia nruab nrab ntawm cov tshuaj tua kab mob yog 4,3-4.5 ntawm 5 lub ntsiab lus.

Cov kev tshuaj xyuas txog Augmentin tseg los ntawm leej niam ntawm cov menyuam yaus qhia tias cov cuab yeej pab tau daws sai sai nrog cov kab mob xws li mob thaum yau mob ntsws lossis mob caj pasCov. Ntxiv nrog rau qhov ua tau zoo ntawm cov tshuaj, cov niam kuj tseem nco qab nws cov qab ntxiag, uas cov menyuam nyiam.

Cov cuab yeej ua haujlwm kuj tseem muaj txiaj ntsig thaum cev xeeb tub. Txawm hais tias qhov tseeb hais tias qhov kev qhia tsis pom zoo kev kho mob nrog cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub sijhawm 1 lub sijhawm), Augmentin feem ntau yog txiav txim siab thib 2 thiab thib 3 txiav.

Raws li cov kws kho mob, qhov loj tshaj plaws thaum kho nrog cov cuab yeej no yog soj ntsuam qhov ntau npaum li cas thiab ua raws txhua qhov kev pom zoo ntawm koj tus kws kho mob.

Tus nqi ntawm Augmentin hauv Ukraine nws txawv nyob ntawm lub tsev muag tshuaj tshwj xeeb. Nyob rau tib lub sijhawm, tus nqi ntawm cov tshuaj yog me ntsis siab dua hauv cov khw muag tshuaj hauv Kiev, ntsiav tshuaj thiab kua txiv hauv cov chaw muag tshuaj hauv Donetsk, Odessa lossis Kharkov raug muag ntawm tus nqi me ntsis.

625 mg ntsiav tshuaj (500 mg / 125 mg) tau muag hauv khw muag tshuaj, ntawm thaj tsam, ntawm 83-85 UAH. Tus nqi nruab nrab ntawm Augmentin ntsiav tshuaj 875 mg / 125 mg - 125-135 UAH.

Koj tuaj yeem yuav cov tshuaj tua kab mob hauv cov hmoov ntawv rau kev npaj cov tshuaj rau kev txhaj tshuaj nrog qhov tshuaj ntawm 500 mg / 100 mg ntawm cov tshuaj yeeb dej caw, ntawm qhov nruab nrab, rau 218-225 UAH, tus nqi nruab nrab ntawm Augmentin 1000 mg / 200 mg - 330-354 UAH.

Nqe ntawm Augmentin kev ncua rau cov menyuam yaus:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

• Cov Tshuaj Online Online hauv Russia
• Cov chaw muag tshuaj online ntawm UkraineUkraine
• Cov chaw muag tshuaj online hauv Kazakhstan

Augmentin Hmoov 228,5 mg / 5 ml 7.7 g 70 ml GlaxoSmithKline

Augmentin ntsiav tshuaj 250 mg + 125 mg 20 pcs. GlaxoSmithKline

Augmentin Hmoov 642.9 mg / 5 ml 100 ml

Augmentin Hmoov 457 mg / 5 ml 12.6 g 70 ml

Augmentin Hmoov 100 ml GlaxoSmithKline

Augmentin 250mg / 125mg No. 20 ntsiav tshuaj SmithKline Beech PiElSi

Augmentin 125mg / 31.25mg / 5ml 100ml hmoov rau kev ncua ntawv SmithKline Beech PiElSi

Augmentin EU hmoov rau kev ncua 600mg + 42.9mg No. 1 lub raj mis GlaxoSmithKline

Augmentin 1000mg No. 14 ntsiav tshuaj SmithKline Beech PiElSi

Augmentin 200mg / 28.5mg / 5ml 70ml hmoov rau kev ncua ntawv SmithKline Beech PiElSi

Kws tshuaj IFK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

Augmentin SB Pharmaceuticals (UK)

Augmentin tab. 500mg / 125mg No. 14 Velcom Foundation GW (UK)

Augmentin BD ntsiav tshuaj 625mg No. 14 Velcom Foundation GW (UK)

Augmentin SRGlaxo Wellcome Production (Fabkis)

Augmentin hmoov rau qhov kev npaj ntawm txhaj tshuaj tov 600mg No. 10Glaxso Velcom GW (Great Britain)

Pani Cov Tshuaj

Augmentin tom qab ntawd. d / p phoov 228.5mg / 5ml 70ml Glaxo Zoo

Augmentin tom qab ntawd. d / p phoov 228.5mg / 5ml 70ml Glaxo Zoo

Augmentin tom qab ntawd. d / p phoov 228.5mg / 5ml 70ml Glaxo Zoo

Augmentin 500 mg / 125 mg No. 14 ntsiav tshuaj los ntawm SmithKline Beecham Pharmaceuticals (UK)

Augmentin 156 mg / 5 ml 100 ml por.d / phoov SmithKline Beecham Pharmaceuticals (UK)

Augmentin 400mg / 57mg / 5ml 35 ml por.d / susp. SmithKline Beecham Tshuaj (UK)

Augmentin 875 mg / 125 mg No. 14 tabl.smithKline Beecham Pharmaceuticals (Great Britain)

Augmentin 200mg / 28.5mg / 5ml 70 ml por.d / susp. SmithKline Beecham Tshuaj (UK)

THEM SAIB! Cov ntaub ntawv hais txog cov tshuaj ntawm lub xaib yog kev saib xyuas-dav dav, sau los ntawm pej xeem cov chaw thiab tsis tuaj yeem ua lub hauv paus rau kev txiav txim siab txog kev siv tshuaj thaum lub sijhawm kho mob. Ua ntej siv cov tshuaj Augmentin, nco ntsoov sab laj nrog koj tus kws kho mob.

Kev piav qhia cuam tshuam rau 26.09.2014

• Lub npe Latin: Augmentin
• ATX Code: J01CR02
• Yam tshuaj muaj sia: Amoxicillin (Amoxicillin) + Clavulanic acid (Clavulanic acid)
• Chaw tsim tshuaj paus: GlaxoSmithKline plc, UK

Hauv ib qhov ncauj ntsiav tshuaj muaj 0.25, 0.5 lossis 0.875 g amoxicillin trihydrate thiab 0.125 g clavulanic acid(hauv kev tsim cov tshuaj, clavulanate sodium yog tso nrog 5% ntau dhau).

Hauv tshuaj ntsiav ntu ntu: Silicii dioxideydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Ib fwj hmoov rau kev npaj daws rau kev txhaj tshuaj muaj 0.5 lossis 1 g amoxicillin trihydrate thiab, feem, 0.1 lossis 0.2 g clavulanic acid.

Cov muaj pes tsawg leeg Augmentin hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj suav nrog 0.125 / 0.2 / 0.4 g (5 ml) amoxicillin trihydrate thiab, feem, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Xanthan ntawm cov pos hniav, Hydroxypropyl methylcellulose, Silicii dioxideydum colloidale, Acidum succinicum, Silicii dioxideydum, Aspartamum (E951), qhuav - txiv kab ntxwv tsw qab (610271E thiab 9/027108), txiv pos thiab "Bright molasses".

Hauv hmoov Augmentin EU npaj rau kev npaj ntawm 100 ml ntawm kev ncuamuaj 0.6 g (5 ml) amoxicillin trihydrate thiab 0.0429 g (5 ml) clavulanic acid.

Ntu Cheebtsam: Silicii dioxideydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan ntawm cov pos hniav, Silicii Dydydum, tsw tsw qab 544428.

Hauv qhov muaj pes tsawg leeg ntawm ib qho Augmentin CP ntsiav tshuaj nrog rau kev ua ntev nrog rau 1 g amoxicillin trihydrate thiab 0.0625 g clavulanic acid.

Ntu Cheebtsam: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxideydum colloidale, Magnesium stearate, Xanthan ntawm cov pos hniav, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum 3350, Macrogolum

Daim ntawv tso tawm

Cov tshuaj muaj daim ntawv tso tawm hauv qab no:

• Augmentin ntsiav tshuaj 250 mg + 125 mg, Augmentin 500 mg + 125 mg thiab Augmentin 875 + 125 mg.
• Hmoov 500/100 mg thiab 1000/200 mg, npaj rau kev npaj ntawm kev daws rau kev txhaj tshuaj.
• Hmoov rau kev ncua ncua Augmentin 400 mg / 57 mg, 200 mg / 28.5 mg, 125 mg / 31.25 mg.
• Hmoov Augmentin EU 600 mg / 42.9 mg (5 ml) rau kev ncua.
• Augmentin CP 1000 mg / 62.5 mg txhawb cov ntsiav tshuaj tso tawm

Pharmacological kev txiav txim

Augmentin belongs rau cov pab pawg muab tshuaj kho mob "Cov tshuaj tua kab mob rau kev siv kab ke. -lactams. Penicillins. "

Cov nyhuv pharmacological ntawm cov tshuaj yog Tshuaj tua kab mob thiab tua kab mob.

Pharmacodynamics thiab pharmacokinetics

Raws li Wikipedia, Amoxicillin yog cov kab mob bactericidalzoo tiv thaiv ntau yam kab mob thiab cov kab mob muaj peev xwm cov kab mob me me thiab sawv cev semisynthetic penicillin pawg tshuaj tiv thaiv.

Txhawb pab transpeptidase thiab cuam tshuam nrog kev tsim khoom mureina (qhov tseem ceeb tshaj plaws ntawm cov phab ntsa ntawm cov kab mob hauv lub cev) thaum lub sijhawm faib thiab kev loj hlob, nws provokes li lysis (kev rhuav tshem) cov kab mob.

Amoxicillin raug rhuav tshem -lactamasesyog li nws cov kev ua haujlwm tiv thaiv kab mob tsis txuas ntxiv cov kab mob me metsim khoom -lactamases.

Ua raws li kev sib tw thiab nyob rau hauv feem ntau ntawm ib tug tsis tuaj yeem inhibitor, clavulanic acid tsiag ntawv los ntawm kev muaj peev xwm txeem ntxeem phab ntsa cov kab mob thiab ua rau inactivation cov enzymesuas muaj nyob ntawm ob sab ntawm tes thiab ntawm nws cov ciam teb.

Clavulanate cov ntaub ntawv ruaj khov inactivated complexes nrog -lactamasesthiab no nyeg tiv thaiv kev puas tsuaj amoxicillin.

Augmentin tshuaj tua kab mob zoo tiv thaiv:

• Nyiaj Gram (+) aerobes: pyogenic mob streptococcus pawg A thiab B, pneumococci, Staphylococcus aureus thiab mob sab nrauv, (tshwj tsis yog zam ntawm kab mob methicillin-tiv taus lim tawm), saprophytic staphylococcus thiab lwm tus
• Nyiaj Gram (-) aerobes: Pfeiffer nrog, mob hnoos hawb pob, gardnerella vaginalis , Mob raws plab lwm yam.
• Gram (+) thiab Gram (-) ntawm anaerobes: bacteroids, fusobacteria, preotellaslwm yam.
• Lwm yam kab mob me me: mob chlamydia, spirochete, daj ntseg treponema lwm yam.

Tom qab kev siv cov tshuaj Augmentin, ob qho ntawm nws lub cev ua kom nrawm nrawm thiab nqus tawm ntawm qhov hnyuv. Kev nqus tau yog qhov zoo dua yog tias ntsiav tshuaj lossis kua dej cawv thaum noj mov (thaum pib noj mov).

Ob qho tib si thaum noj ntawm qhov ncauj, thiab nrog cov lus qhia ntawm Augmentin IV kev daws teeb meem, kev kho tshuaj ntau ntawm cov tshuaj ua kom muaj zog nyob hauv txhua cov ntaub so ntswg thiab cov kua dej ua kua interstitial.

Ob leeg lub zog ua kom tsis muaj zog khi rau ntshav ntshav protein (txog 25% khi rau cov ntshav protein amoxicillin trihydratethiab tsis ntau tshaj 18% clavulanic acid) Tsis muaj qhov mus ntxiv ntawm Augmentin raug kuaj pom ib qho ntawm cov kabmob hauv nruab nrog.

Amoxicillin nphav raug kev zom mov nyob rau hauv lub cev thiab excreted ob lub raumlos ntawm kev zom cov pa zom zaws thiab hauv daim ntawv cov roj carbon dioxide nrog rau cov pa tawm kom zoo. 10 txog 25% ntawm qhov koob tau txais amoxicillin raug zam ob lub raum hauv daim ntawv penicilloic aciduas yog nws tsis tsaug zog metabolite.

Clavulanate raug tawm ob leeg los ntawm lub raum thiab los ntawm txoj kev ua cov txheej txheem ntxiv.

Kev ntsuas rau siv

Kev taw qhia rau kev siv ntawm kev sib xyaw amoxicillin trihydrate thiab clavulanic acid yog kis tau tus mobprovoked los ntawm rhiab rau qhov kev txiav txim ntawm cov tshuaj no cov kab mob me me.

Kev kho mob Augmentin tseem raug tso cai. kis tau tus mobtshwm sim los ntawm kev ua si cov kab mob me merhiab rau kev txiav txim amoxicillinthiab li sib xyaw kis tau tus mobprovoked los ntawm rhiab rau cov kab mob amoxicillin thiab cov kab mob uas tsim tawm -lactamasethiab raug cim los ntawm rhiab xav rau kev sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Hauv Is Taws Nem, cov lus nug feem ntau nug “Cov ntsiav tshuaj Augmentin yog los ntawm dab tsi? "Los sis" Augmentin Syrup Curing yog dab tsi? ".

Kev thaj tsam ntawm cov tshuaj no nws kim heev. Nws yog tshuaj rau hauv qab no kab mob sib kis thiab kab mob:

• ntawm kis tau tus mobcuam ​​tshuam qaum thiab qis cov pa ua pa (suav nrog suav nrog Cov mob ENT),
• ntawm kis tau tus mobcuam ​​tshuam genitourinary huam,
• ntawm odontogenic (mob hauv qhov ncauj) mob,
• ntawm cov kab mob gynecological,
• ntawm gonorrhea,
• ntawm kis tau tus mobcuam ​​tshuam daim tawv nqaij thiab cov nqaij mos,
• ntawm kis tau tus mobcuam ​​tshuam nqaij pob txha(suav nrog yog tias tsim nyog, kev teem sij hawm ntawm kev kho mob mus ntev rau tus neeg mob),
• lwm yam kis tau tus mob hom sib xyaw (piv txwv li tom qab septic rho menyuamntawm sepsis nyob rau lub sijhawm ua haujlwm tom qab yug menyuam tas, nrog septicemia (sepsis tsis muaj metastases), mob peritonitisntawm sepsistshwm sim los ntawm kev kis tus mob intraabdominalntawm kis tau tus mobtsim tom qab kev phais mob).

Augmentin feem ntau yog siv los tiv thaiv kev ntsuas ua ntej ua cov kev phais loj rau kev ua haujlwm taub hau, caj dab, lub plab zom mov, lub raum, mob plab, ntawm cov kabmob uas nyob hauv plab hu ua pelvic.thiab raws li thaum lub sij hawm tus txheej txheem cog cov khoom hauv nruab nrog cev.

Cov Yuav Tsum Muaj

Augmentin nyob rau hauv txhua daim ntawv qhia cov tshuaj yog contraindicated:

• cov neeg mob uas lub siab tsis haum rau ib lossis ob qho kev sib txuas ntawm cov tshuaj, rau ib qho ntawm nws qhov kev tshem tawm, ntxiv rau -lactam (i.e. to tshuaj tua kab mob los ntawm tej pab pawg tshuaj penicillin thiab cephalosporin),
• cov neeg mob uas tau ntsib kev kho mob ntawm Augmentin kho mob dajntoo lossis keeb kwm ntawm qhov tsis taus zoo mob siab vim kev siv tshuaj sib txuas ntawm cov tshuaj nquag ntawm cov tshuaj.

Ib qho kev tiv thaiv ntxiv rau kev teem caij ua hmoov rau kev npaj ntawm qhov ncauj tshem tawm nrog qhov ntau npaum ntawm cov tshuaj dej ntawm 125 + 31.25 mg yog PKU (phenylketonuria).

Lub hmoov siv rau kev npaj ntawm qhov ncauj ncua nrog qhov ntau npaum ntawm cov tshuaj dej (200 + 28.5) thiab (400 + 57) mg yog contraindicated:

• ntawm PKU,
• cov neeg mob uas tsis taus raumntawm qhov ntsuasReberg kev ntsuam xyuas hauv qab no 30 ml ib feeb
• cov menyuam yaus hnub nyoog qis dua 3 hlis.

Ib qho kev tiv thaiv ntxiv rau kev siv cov ntsiav tshuaj nrog cov tshuaj ntau dua (250 + 125) thiab (500 + 125) mg yog lub hnub nyoog qis dua 12 xyoos thiab / lossis hnyav dua 40 phaus.

Cov ntsiav tshuaj nrog qhov ntau npaum ntawm cov tshuaj nquag 875 + 125 mg yog contraindicated:

• ua txhaum txoj haujlwm kev ua haujlwm raum (ntsuas Reberg kev ntsuam xyuas hauv qab 30 ml ib feeb)
• cov me nyuam qis dua 12 xyoos
• cov neeg mob uas lub cev tsis hnyav tshaj 40 kg.

Sab sij huam

Kev phiv los ntawm Augmentin tuaj yeem tshwm sim los ntawm ntau lub tshuab thiab ib tus kabmob. Feem ntau cov feem ntau, tiv thaiv keeb kwm ntawm kev siv tshuaj kho yeeb tshuaj, cov kev coj ua hauv qab no tuaj yeem pom:

• candidiasis (pom quav)ntawm daim tawv nqaij thiab mucous daim nyias nyias,
• zawv plab(ntau zaus - thaum noj Augmentin hauv cov ntsiav tshuaj, feem ntau thaum noj ncua lossis txhaj tshuaj),
• bouts ntawm xeev siab thiab ntuav (xeev siab feem ntau tshwm sim thaum noj cov tshuaj hauv qhov siab).

Tej kev phiv uas tshwm sim muaj xws li:

• kiv taub hau,
• mob taub hau,
• dysfunctions kev zom plab,
• nce ntxiv hauv daim siab enzyme ua si alanine transaminases (ALT)thiab kev hloov chaw aspartate (AST),
• daim tawv nqaij ua pob, khaus tawvqhov kev tshwm sim urticaria.

Tsawg zaus, lub cev tuaj yeem teb rau kev txais tos ntawm Augmentin:

• thim rov qab leukopenia (suav nrog suav nrog agranulocytosis),
  thrombocytopenia,
• kev txhim kho thrombophlebitis ntawm qhov chaw txhaj tshuaj
• polymorphic erythema.

Tsis tshua muaj neeg tuaj yeem txhim kho:

• hemolytic anemia,
• tej yam kev mob uas pom los ntawm kev nce hauv lub sijhawm los ntshav thiab nce ntxiv prothrombin Performance index,
• kev tawm tsam los ntawm lub cev tiv thaiv kab mobuas qhia raws li angioedema, ib qho syndrome zoo ib yam li qhov tshwm sim hauv ntshiab ntshav mob, anaphylaxis, ua xua vasculitis,
• hyperactivity hom reversible
• nce pom kev ua si,
• tus kausvim kev txais tos tshuaj tua kab mobsuav nrog suav nrog pseudomembranous (PMK) thiab hemorrhagic (qhov ntxim nyiam ntawm kev txhim kho tom kawg poob qis yog tias Augmentin raug tswj hwm los ntawm niam txiv),
• keratinization thiab kev loj hlob ntawm tus nplaig zoo li tus papillae nyob ntawm tus nplaig (kab mob hu ua “tus nplaig plaub hau dub”),
• kab mob siab thiab mob siab cholestasis,
• Lyell cov tsos mob,
• feem ntau exanthematous pustulosisnyob rau hauv daim ntawv mob
• interstitial nephritis,
• cov tsos hauv cov zis ntawm ntsev muaju (crystalluria).

Thaum muaj dermatitis kev ua xua kev kho mob Augmentin yuav tsum tsis ua mus ntxiv.

Cov lus qhia rau kev siv Augmentin: txoj kev thov, ntau npaum li cas rau cov neeg laus thiab menyuam yaus

Ib qho ntawm cov lus nug feem ntau ntawm tus neeg mob yog cov lus nug txog kev noj tshuaj ua ntej lossis tom qab noj mov. Nyob rau hauv rooj plaub ntawm Augmentin, kev noj tshuaj yog ze ze rau kev noj mov. Nws yog suav hais tias yog qhov zoo tshaj rau noj cov tshuaj ncaj qha. ua ntej noj mov.

Ua ntej, nws muab kev nqus zoo dua ntawm lawv cov tshuaj nquag Kev kho mob txoj hnyuv, thiab, ob, nws tuaj yeem txo qhov hnyav Mob plab zom mov tsis haum ntawm lub plab zom movyog tom kawg ntawv xwb.

Yuav ua li cas los xam cov koob tshuaj ntawm Augmentin

Yuav ua li cas noj cov tshuaj Augmentin rau cov neeg laus thiab menyuam yaus, nrog rau nws txoj kev kho kom haum, nyob ntawm seb qhov twg microorganism yog ib tug kab mob, kev rhiab npaum li cas yog nws raug tshuaj tua kab mob, qhov mob hnyav thiab cov yam ntxwv ntawm chav kawm ntawm tus kabmob, kev ua kom pom ntawm thaj chaw sib kis, lub hnub nyoog thiab qhov hnyav ntawm tus neeg mob, nrog rau nws noj qab haus huv npaum li cas ob lub raum tus neeg mob.

Lub sijhawm tiv thaiv ntawm cov chav kho yog nyob ntawm seb tus neeg mob lub cev teb li cas rau kev kho mob.

Augmentin ntsiav tshuaj: cov lus qhia rau kev siv

Ua raws li cov ntsiab lus ntawm cov tshuaj yeeb dej caw hauv lawv, Augmentin ntsiav tshuaj raug pom zoo rau cov neeg mob laus kom noj raws li cov qauv hauv qab no:

• Augmentin 375 mg (250 mg + 125 mg) - ib peb zaug ib hnub. Hauv kev siv ntau npaum li cas, cov tshuaj tau qhia rau kis tau tus mobuas ntws hauv yooj yim lossis tsim nyog me. Thaum muaj mob hnyav, suav nrog mob ntev thiab rov tshwm sim, ntau dua qhov tau muab tshuaj.
• Cov ntsiav tshuaj 625 mg (500 mg + 125 mg) - ib peb zaug ib hnub.
• 1000 mg ntsiav tshuaj (875 mg + 125 mg) - ib hnub ob zaug.

Qhov hno yog raug rau kev kho rau cov neeg mob uas tsis muaj lub luag haujlwm. raum.

Augmentin CP 1000 mg / 62.5 mg cia cov ntsiav tshuaj tso tawm tsuas yog pub rau cov neeg mob hnub nyoog 16 xyoo rov hauv. Cov koob tshuaj zoo yog ob ntsiav tshuaj ib hnub ob zaug.

Yog tias tus neeg mob tsis tuaj yeem nqos tag nrho cov ntsiav tshuaj, nws muab faib ua ob kab raws txoj kab txhaum. Ob qho tib si ob leeg tau coj tib lub sijhawm.

Cov neeg mob nrog rau cov neeg mob ob lub raum cov tshuaj yog kws kho tsuas yog hauv qhov xwm txheej ntawm qhov ntsuas Reberg kev ntsuam xyuas ntau tshaj 30 ml tauj ib feeb (uas yog, thaum kho kom haum rau qhov tshuaj ntau npaum li cas tsis tas yuav).

Hmoov rau cov tshuaj rau kev txhaj tshuaj: cov lus qhia rau kev siv

Raws li cov lus qhia, txoj kev daws teeb meem yog txhaj rau hauv txoj leeg: los ntawm dav hlau (qhov koob tshuaj yuav tsum tau txhaj tshuaj hauv 3-4 feeb) lossis los ntawm cov txheej txheem dej (lub sijhawm ntawm Txoj kev lis ntshav yog los ntawm ib nrab ntawm ib teev mus rau 40 feeb). Txoj kev daws tsis tau xav kom tau txhaj tshuaj rau hauv cov leeg.

Cov qauv muab rau ib tus neeg mob laus yog 1000 mg / 200 mg. Nws raug nquahu kom nkag nws txhua yim teev, thiab rau cov uas muaj teeb meem kis tau tus mob - txhua rau lossis rau plaub teev (raws li qhia).

Tshuaj tua kab mob hauv kev txiav txim siab ntawm tshuaj, 500 mg / 100 mg lossis 1000 mg / 200 mg yog tau sau tseg rau kev tiv thaiv kev txhim kho kis mob tom qab phais tasCov. Hauv kis uas lub sijhawm ua haujlwm tsawg dua li ib teev, nws txaus rau nkag mus rau tus neeg mob ib zaug ua ntej Tshuaj loog koob tshuaj ntawm Augmentin 1000 mg / 200 mg.

Yog tias nws cia siab tias qhov kev ua haujlwm yuav kav ntev dua li ib teev, txog plaub koob ntawm 1000 mg / 200 mg tau muab rau tus neeg mob nyob rau hnub dhau los rau 24 teev.

Kev ncua Augmentin: cov lus qhia rau kev siv

Cov lus qhia rau kev siv Augmentin rau menyuam yaus pom zoo kom teem sij hawm ncua ntawm 125 mg / 31.25 mg hauv koob tshuaj 2.5 txog 20 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 3 thaum nruab hnub. Qhov ntim ntawm ib koob tshuaj nyob ntawm lub hnub nyoog thiab qhov hnyav ntawm tus menyuam.

Yog tias tus menyuam loj dua ob lub hlis ntawm hnub nyoog, ncua kev ncua 200 mg / 28.5 mg yog tau sau rau hauv koob tshuaj ib yam li 25 / 3.6 mg rau 45 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav. Cov koob tshuaj uas tau hais tseg yuav tsum muab faib ua ob zaug.

Qhov ncua kev kawm ntawv nrog rau qhov ntau npaum ntawm cov tshuaj 400 mg / 57 mg (Augmentin 2) yog qhia rau kev siv pib txij li xyoo. Nyob ntawm seb tus me nyuam muaj hnub nyoog thiab hnyav li cas, ib koob tshuaj nws txawv ntawm 5 mus rau 10 ml. Kev muaj txiaj ntsig ntau ntawm kev txais khoom - 2 thaum nruab hnub.

Augmentin EU yog pib txij 3 lub hlis hnub nyoog. Cov koob tshuaj zoo tshaj plaws yog 90 / 6.4 mg rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub (qhov koob tshuaj yuav tsum tau muab faib ua 2 koob, khaws ib ntu 12-teev nruab nrab ntawm lawv).

Niaj hnub no, cov tshuaj hauv ntau hom tshuaj yog ib qho ntawm cov tshuaj tshaj plaws rau kev kho mob. mob qa.

Cov me nyuam Augmentin nrog mob caj pas sau rau hauv lub koob tshuaj uas tau txiav txim siab raws lub cev qhov hnyav thiab hnub nyoog ntawm tus menyuam. Nrog angina rau cov neeg laus, nws raug nquahu kom siv Augmentin 875 + 125 mg peb zaug ib hnub.

Tsis tas li, lawv feem ntau yog mus rau lub sijhawm Augmentin mob hlab ntswsCov. Txoj kev kho yog ntxiv los ntawm kev ntxuav lub qhov ntswg nrog ntsev hiav txwv thiab siv tshuaj txau qhov ntswg ntawm hom RinofluimucilCov. Koob tshuaj zoo rau mob hlab ntsws: 875/125 mg 2 zaug ib hnub.Lub sijhawm ua haujlwm ntawm feem ntau yog 7 hnub.

Noj ntau dhau

Tshaj dhau qhov koob ntawm Augmentin tau nrog los ntawm:

• kev txhim kho ntawm kev ua txhaum los ntawm cov hnyuv,
• ua txhaum ntawm dej-ntsev tshuav,
• crystalluria,
• lub raum tsis ua hauj lwm,
• nag lossis daus (nag lossis daus) ntawm amoxicillin nyob rau hauv lub raj tso zis.

Thaum cov tsos mob zoo li no tshwm sim, tus neeg mob tau qhia pom muaj kev kho mob, nrog rau, ntawm lwm yam, kev kho ntawm cov dej-ntsev kom sib npaug. Thim ntawm Augmentin los ntawm rauequilibrium system kuj pab txhawb tus txheej txheem hemodialysis.

Kev sib txuam

• pab txo kom tsawg tubular zais cia ntawm amoxicillin,
• provokes ib qho kev nce nyob rau hauv concentration amoxicillin hauv ntshav ntshav (cov nyhuv cuam tshuam ntev mus),
• tsis cuam tshuam rau cov khoom thiab theem ntawm cov ntsiab lus hauv clavulanic acid ntshav ntshav.

Sib txuam ua ke amoxicillin nrog allopurinol nce txoj kev nyiam qhov zuj zus ua xuaCov. Cov ntaub ntawv sib cuam tshuam allopurinol ib txhij nrog ob qho kev nquag ntawm Augmentan tsis tuaj.

Augmentin muaj cov nyhuv hauv uas muaj nyob hauv txoj hnyuv microflorauas provokes ib tug txo nyob rau hauv reabsorption (thim rov qab haum) tshuaj estrogen, nrog rau kev txo qis hauv cov txiaj ntsig ntawm kev sib xyaw ua ke tshuaj tiv thaiv rau kev siv qhov ncauj.

Cov tshuaj tsis sib xws nrog cov ntshav cov ntshav thiab cov kua-muaj kua, nrog rau suav nrog whey protein hydrolysates thiab roj emulsions npaj rau kev ntxig rau hauv cov leeg ntshav.

Yog tias Augmentin tawm tshuaj nrog rau tshuaj tua kab mob chav kawm aminoglycosides, cov tshuaj tsis sib xyaw rau hauv ib lub koob txhaj tshuaj lossis lwm lub thauv tshuaj ua ntej kev tswj hwm, vim tias qhov no ua rau tsis muaj zog aminoglycosides.

Cov nqe lus ntawm kev muag khoom

Cia rau cov neeg mob

Kev npaj cov khoom ntim thaum xub thawj yog khaws cia ntawm qhov kub uas tsis tshaj 25 ° C. Qhov tshem tawm yuav tsum khaws cia ntawm qhov kub ntawm 2-8 ° C (zoo tshaj hauv tub yees) tsis pub ntev tshaj 7 hnub.

Hnub tas sij hawm

Nws tsim nyog siv nyob rau hauv 2 xyoos txij li hnub ntawm kev tsim khoom lag luam.

Cov Lus Qhia Txog Augmentin

Augmentin analogs yog cov tshuaj A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Medoclave, Teraclav.

Txhua ntawm cov tshuaj saum toj no yog dab tsi Augmentin tuaj yeem hloov pauv hauv nws qhov tsis tuaj.

Tus nqi ntawm cov khoom tsis txawv txav los ntawm 63.65 txog 333.97 UAH.

Augmentin rau menyuam yaus

Augmentin siv dav hauv kev xyaum tsiaj txhu. Vim qhov tseeb tias nws muaj menyuam yaus daim ntawv tso tawm - kua phoov, nws tuaj yeem siv tau los kho menyuam yaus rau ib xyoos xwb. Kev teeb tsa tshwj xeeb ua rau txais tos thiab qhov tseeb hais tias cov tshuaj muaj cov khoom qab ntxiag.

Rau menyuam tshuaj tua kab mobfeem ntau kho mob rau mob caj pasCov. Qhov ntau npaum li cas ntawm kev ncua rau cov me nyuam yog txiav txim siab los ntawm lub hnub nyoog thiab qhov hnyav. Cov koob tshuaj zoo tshaj plaws tau muab faib ua ob koob, sib npaug 45 mg / kg ib hnub, lossis faib ua peb koob, koob tshuaj 40 mg / kg ib hnub.

Kev siv cov tshuaj rau cov menyuam yaus thiab caij nyoog ntau npaum li cas yog nyob ntawm daim ntawv ntau npaum li cas.

Rau cov menyuam yaus lub cev qhov hnyav tshaj 40 kg, Augmentin raug tso cai tib yam li cov neeg laus.

Augmentin phoov rau cov menyuam yaus txog li ib xyoos yog siv hauv qhov ntau ntawm 125 mg / 31.25 mg thiab 200 mg / 28.5 mg. Kev noj tshuaj ntawm 400 mg / 57 mg yog qhia rau cov menyuam yaus tshaj ib xyoos.

Cov menyuam yaus nyob rau hauv hnub nyoog 6-12 xyoo (hnyav dua 19 kg) raug tso cai siv ob qho kev ncua lossis Augmentin hauv cov ntsiav tshuaj. Kev muab tshuaj ntawm lub ntsiav tshuaj daim ntawv tshuaj yog raws li nram no:

• ib ntsiav tshuaj 250 mg + 125 mg peb zaug ib hnub,
• ib ntsiav tshuaj 500 + 125 mg ob zaug ib hnub (daim ntawv teev ntau npaum li no yog txoj kev pom zoo).

Cov menyuam yaus hnub nyoog dhau 12 xyoos raug samfwm kom noj ib ntsiav tshuaj ntawm 875 mg + 125 mg ob zaug ib hnub.

Txhawm rau kom ntsuas qhov tseeb ntawm koob tshuaj Augmentin kev ncua rau cov menyuam muaj hnub nyoog qis dua 3 hlis, nws pom zoo kom ntaus cov lej nrog ib rab koob uas muaj qhov cim. Txhawm rau kom siv txoj kev siv ncua kev kawm ntawv hauv cov menyuam yaus hauv qab ob xyoos, nws tau tso cai kom cov kua dej nrog cov dej hauv qhov piv rau 50/50

Augmentin's analogues, uas yog nws txoj kev hloov pauv chaw muag tshuaj, yog cov tshuaj Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Lub Ecoclave.

Cawv tau zoo

Augmentin thiab cawv yog qhov kev xav tsis yog kev tawm tsam los ntawm cov cawv cawv ethyl tshuaj tua kab mobtsis pauv nws lub zog pharmacological.

Yog tias tawm tsam keeb kwm ntawm kev siv tshuaj yeeb muaj qhov xav kom haus dej haus cawv, nws yog ib qho tseem ceeb kom soj ntsuam ob yam kev mob: kev sim thiab maj nrawm.

Rau tib neeg kev txom nyem los ntawm kev quav dej cawv, kev siv yeeb tshuaj nrog cawv ib txhij tuaj yeem muaj kev phom sij loj dua.

Kev siv dej cawv hauv cov dej cawv ua rau cuam tshuam nrog ntau yam kev ntxhov siab hauv kev ua haujlwm mob siabCov. Cov neeg mob nrog tus neeg mob mob siab cov kev qhia pom zoo hais tias Augmentin yuav tsum muaj kev ceev faj heev, vim tias nws tau kwv yees tias yuav ua li cas lub cev muaj kabmob yuav coj tus cwj pwm hauv kev sim kom tiv thaiv. xenobioticnyuaj heev.

Yog li, yuav kom zam kev pheej hmoo tsis txaus ntseeg, nws raug nquahu kom tsis txhob haus cawv thaum lub sijhawm tag nrho ntawm kev kho nrog cov tshuaj.

Augmentin thaum cev xeeb tub thiab lactation

Zoo li feem ntau cov tshuaj tua kab mob penicillin pawg, amoxicillin, muab faib rau hauv cov ntaub so ntswg ntawm lub cev, tseem nkag rau hauv niam mis. Ntxiv mus, kab lus ntau yuav txawm pom nyob hauv mis. clavulanic acid.

Txawm li cas los xij, tsis muaj kev cuam tshuam loj hauv lub tsev kho mob los ntawm tus mob ntawm tus me nyuam yog sau tseg. Hauv qee kis, kev sib xyaw ua ke clavulanic acid nrog amoxicillin tuaj yeem tsim nyob rau hauv tus menyuam zawv plab thiab / lossis candidiasis (thrush) ntawm cov hnoos qeev hauv lub qhov ncauj kab noj hniav.

Augmentin belongs rau cov qeb ntawm cov tshuaj pub mis pub mis. Yog tias, txawm li cas los xij, tiv thaiv keeb kwm ntawm niam txoj kev kho mob nrog Augmentin, tus me nyuam muaj qee qhov tshwm sim tsis zoo, kev pub mis niam yog tso tseg.

Kev tshawb fawb tsiaj tau pom tias cov tshuaj nquag ntawm Augmentin muaj peev xwm nkag mus hematoplacental (GPB) teeb meemCov. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo rau kev loj hlob ntawm tus menyuam hauv plab.

Ntxiv mus, teratogenic teebmeem tau tsis tuaj nrog niam txiv kev coj noj coj ua thiab tshuaj noj ntawm qhov ncauj.

Kev siv cov Augmentin hauv cov poj niam cev xeeb tub tuaj yeem tuaj yeem coj mus rau kev loj hlob ntawm cov menyuam mos necrotizing enterocolitis (NEC).

Zoo li txhua lwm yam tshuaj, Augmentin tsis pom zoo rau cov poj niam cev xeeb tub. Thaum cev xeeb tub, nws siv tau rau qee qhov xwm txheej, raws li kws kho mob qhov kev ntsuas, qhov txiaj ntsig rau tus poj niam muaj ntau tshaj qhov txaus ntshai rau nws tus menyuam.

Kev txheeb xyuas txog Augmentin

Kev tshuaj xyuas ntawm cov ntsiav tshuaj thiab kev ncua rau cov me nyuam Augmentin rau feem ntau zooCov. Coob tus ntsuas cov tshuaj ua tshuaj tau txais txiaj ntsig zoo thiab ntseeg tau.

Ntawm cov chaw sib tham uas tib neeg qhia txog lawv cov kev xav ntawm qee yam tshuaj, cov qhab nia nruab nrab ntawm cov tshuaj tua kab mob yog 4,3-4.5 ntawm 5 lub ntsiab lus.

Cov kev tshuaj xyuas txog Augmentin tseg los ntawm leej niam ntawm cov menyuam yaus qhia tias cov cuab yeej pab tau daws sai sai nrog cov kab mob xws li mob thaum yau mob ntsws lossis mob caj pasCov. Ntxiv nrog rau qhov ua tau zoo ntawm cov tshuaj, cov niam kuj tseem nco qab nws cov qab ntxiag, uas cov menyuam nyiam.

Cov cuab yeej ua haujlwm kuj tseem muaj txiaj ntsig thaum cev xeeb tub. Txawm hais tias qhov tseeb hais tias qhov kev qhia tsis pom zoo kev kho mob nrog cov poj niam cev xeeb tub (tshwj xeeb tshaj yog nyob rau lub sijhawm 1 lub sijhawm), Augmentin feem ntau yog txiav txim siab thib 2 thiab thib 3 txiav.

Raws li cov kws kho mob, qhov loj tshaj plaws thaum kho nrog cov cuab yeej no yog soj ntsuam qhov ntau npaum li cas thiab ua raws txhua qhov kev pom zoo ntawm koj tus kws kho mob.

Augmentin Nqe

Tus nqi ntawm Augmentin hauv Ukraine nws txawv nyob ntawm lub tsev muag tshuaj tshwj xeeb.Nyob rau tib lub sijhawm, tus nqi ntawm cov tshuaj yog me ntsis siab dua hauv cov khw muag tshuaj hauv Kiev, ntsiav tshuaj thiab kua txiv hauv cov chaw muag tshuaj hauv Donetsk, Odessa lossis Kharkov raug muag ntawm tus nqi me ntsis.

625 mg ntsiav tshuaj (500 mg / 125 mg) tau muag hauv khw muag tshuaj, ntawm thaj tsam, ntawm 83-85 UAH. Tus nqi nruab nrab ntawm Augmentin ntsiav tshuaj 875 mg / 125 mg - 125-135 UAH.

Koj tuaj yeem yuav cov tshuaj tua kab mob hauv cov hmoov ntawv rau kev npaj cov tshuaj rau kev txhaj tshuaj nrog qhov tshuaj ntawm 500 mg / 100 mg ntawm cov tshuaj yeeb dej caw, ntawm qhov nruab nrab, rau 218-225 UAH, tus nqi nruab nrab ntawm Augmentin 1000 mg / 200 mg - 330-354 UAH.

Nqe ntawm Augmentin kev ncua rau cov menyuam yaus:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28.5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Yam tshuaj muaj sia:

Pharmacological pawg

Nosological kev faib tawm (ICD-10)

3D duab

1 Hauv kev tsim cov tshuaj, poov tshuaj clavulanate raug nteg nrog 5% ntau dhau.

1 Cov dej lim tawm hauv cov txheej txheej zaj duab xis.

Kev piav qhia ntawm daim ntawv tshuaj

Hmoov: dawb lossis yuav luag dawb, nrog tus yam ntxwv tsw. Thaum diluted, ib qho kev ncua ntawm dawb lossis yuav luag dawb yog tsim. Thaum sawv ntsug, ib qho dej dawb lossis dawb yuav luag nag lossis daus maj mam ua kom qeeb.

Ntsiav tshuaj, 250 mg + 125 mg: them nrog zaj duab xis membrane los ntawm dawb mus rau yuav luag dawb, kheej li lub qw hauv cov duab, nrog cov ntawv sau "AUGMENTIN" ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.

Ntsiav tshuaj, 500 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb hauv cov xim, oval, nrog cov ntawv sau extruded "AC" thiab txoj kev pheej hmoo ntawm ib sab.

Ntsiav tshuaj, 875 mg + 125 mg: npog nrog ib zaj duab xis sheath los ntawm dawb mus rau yuav luag dawb, kheej li lub qw, nrog cov tsiaj ntawv "A" thiab "C" ntawm ob sab thiab ib txoj kab txhaum ntawm ib sab. Ntawm lub kink: los ntawm daj dawb rau yuav luag dawb.

Pharmacological kev txiav txim

Cov Tshuaj Hauv Tshuaj

Amoxicillin yog cov tshuaj tua kab mob ntau tshaj ib nrab hnub nrog kev ua si tiv thaiv ntau yam kab mob gram-positive thiab gram-tsis zoo. Tib lub sijhawm, amoxicillin tiv thaiv kev puas tsuaj los ntawm beta-lactamases, thiab yog li ntawd cov spectrum ntawm kev ua ntawm amoxicillin tsis txuas ntxiv mus rau cov kab mob me me uas tsim cov enzyme no.

Clavulanic acid, beta-lactamase inhibitor yam ntxwv cuam tshuam txog penicillins, muaj peev xwm tsis muaj peev xwm tsis muaj peev xwm ua ntau yam ntawm beta-lactamases pom muaj nyob rau hauv penicillin thiab cephalosporin tiv taus cov kab mob me me. Clavulanic acid muaj txiaj ntsig tiv thaiv plasmid beta-lactamases, uas feem ntau lub luag haujlwm tiv thaiv kab mob, thiab tsis tshua muaj txiaj ntsig tiv thaiv cov chromosomal beta-lactamases ntawm hom 1, uas tsis yog tshuaj tiv thaiv los ntawm clavulanic acid.

Muaj cov clavulanic acid nyob hauv Augmentin ® kev npaj tiv thaiv amoxicillin los ntawm kev puas tsuaj los ntawm cov enzymes - beta-lactamases, uas tso cai rau nthuav cov tshuaj tua kab mob ntawm amoxicillin.

Hauv qab no yog cov haujlwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid hauv vitro .

Cov kab mob feem ntau cuam tshuam rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid

Gram-zoo aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogenes, Nocardia asteroides, Streptococcus spp., suav nrog Tus kab mob Streptococcus pyogenes 1.2, Streptococcus agalactiae 1.2 (lwm beta hemolytic streptococci) 1,2, Dab Tsi Staphylococcus aureus (rhiab rau methicillin) 1, Dab Tsi Staphylococcus saprophyticus (rhiab rau methicillin), coagulase-negative staphylococci (rhiab rau methicillin).

Gram-zoo anaerobes: Clostridium spp., Peptococcus niger, Peptostreptococcus spp., suav nrog Peptostreptococcus magnus, Peptostreptococcus micros.

Gram-negative aerobes: Tus mob Bordetella pertussis, Haemophilus influenzae 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Gram-negative anaerobes: Cov ntsiab lus Bacteroides spp., suav nrog Bacteroides fragilis, Capnocytophaga spp., Eikenella corrodens, Fusobacterium spp., suav nrog Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Lwm yam: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Cov kab mob rau cov uas yuav tiv taus cov tshuaj amoxicillin nrog clavulanic acid yog qhov yuav tshwm sim

Gram-negative aerobes: Escherichia coli 1, Klebsiella spp., suav nrog Klebsiella oxytoca, Klebsiella pneumoniae 1, Proteus spp., suav nrog Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Gram-zoo aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus mob ntsws 1,2 pab pawg neeg streptococcus Viridans.

Cov kab mob uas ib txwm muaj peev xwm tiv thaiv kev sib txuas ntawm amoxicillin nrog clavulanic acid

Gram-negative aerobes: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Lwm yam: Chlamydia spp., suav nrog Chlamydia mob ntsws, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Rau cov kab mob no, kev kho mob ua tau zoo ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid tau ua kom pom hauv kev tshawb fawb soj ntsuam.

2 Hom kab ntawm cov kab mob no tsis tsim cov tshuaj beta-lactamase. Kev nkag siab nrog amoxicillin monotherapy qhia qhov zoo sib xws mus rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Cov Tshuaj Pharmacokinetics

Ob lub cev sib xyaw ntawm Augmentin ® kev npaj - amoxicillin thiab clavulanic acid - tau sai thiab tag nrho los ntawm txoj hnyuv plab tom qab kev tswj hwm qhov ncauj. Qhov nqus ntawm cov khoom xyaw nquag ntawm cov tshuaj Augmentin ® yog qhov zoo dua rau thaum muaj kev noj tshuaj thaum pib noj mov.

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2-12 xyoo rau lub plab khoob siv 40 mg + 10 mg / kg / hnub ntawm Augmentin ® hauv peb koob tshuaj, hmoov rau lub qhov ncauj ncua, 125 mg + 31.25 mg hauv 5 ml (156.25 mg).

Yooj yim pharmacokinetic

Augmentin ®, 125 mg + 31.25 mg hauv 5 ml

Augmentin ®, 125 mg + 31.25 mg hauv 5 ml

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau nyob rau hauv cov kev tshawb fawb sib txawv yog qhia hauv qab no, thaum cov neeg ua haujlwm noj qab haus huv muaj hnub nyoog 2–12 xyoo rau ntawm lub plab khoob tau Augmentin ®, hmoov rau lub qhov ncauj ncua, 200 mg + 28.5 mg hauv 5 ml (228 , 5 mg) ntawm ib koob ntawm 45 mg + 6.4 mg / kg / hnub, muab faib ua ob zaug.

Yooj yim pharmacokinetic

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid tau txais hauv kev tshawb fawb sib txawv yog qhia hauv qab no thaum cov neeg tuaj yeem noj qab haus huv tau noj ib zaug ntawm Augmentin ®, hmoov rau kev tshem tawm qhov ncauj, 400 mg + 57 mg hauv 5 ml (457 mg).

Yooj yim pharmacokinetic

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb sib txawv, thaum cov neeg tuaj yeem yoo mov sai:

- 1 tab. Augmentin ®, 250 mg + 125 mg (375 mg),

- 2 ntsiav tshuaj Augmentin ®, 250 mg + 125 mg (375 mg),

- 1 tab. Augmentin ®, 500 mg + 125 mg (625 mg),

- 500 mg ntawm amoxicillin,

- 125 mg ntawm clavulanic acid.

Yooj yim pharmacokinetic

Amoxicillin nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Clavulanic acid nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Thaum siv cov tshuaj Augmentin ®, ntshav ntau ntawm amoxicillin zoo ib yam li cov tshuaj noj ntawm qhov ncauj ntawm amoxicillin koob tshuaj sib npaug.

Cov tshuaj pharmacokinetic ntawm amoxicillin thiab clavulanic acid, tau txais hauv kev tshawb fawb cais, thaum muaj kev noj qab haus huv sai sai cov neeg ua haujlwm nqa:

- 2 ntsiav tshuaj Augmentin ®, 875 mg + 125 mg (1000 mg).

Yooj yim pharmacokinetic

Amoxicillin nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Augmentin ®, 875 mg + 125 mg

Clavulanic acid nyob rau hauv muaj pes tsawg leeg ntawm cov tshuaj Augmentin ®

Augmentin ®, 875 mg + 125 mg

Ib yam li iv kev tswj hwm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev kho mob ntau ntawm amoxicillin thiab clavulanic acid muaj nyob hauv ntau cov ntaub so ntswg thiab cov kua dej interstitial (gall zais zis, lub plab hauv plab, tawv nqaij, rog thiab cov leeg nqaij, synovial thiab peritoneal kua, kua tsib, kua paug) )

Amoxicillin thiab clavulanic acid muaj qhov tsis muaj zog ntawm kev cog lus rau cov ntshav protein. Cov kev tshawb fawb pom tau tias kwv yees li 25% ntawm tag nrho cov nyiaj clavulanic acid thiab 18% ntawm amoxicillin hauv ntshav plasma khi rau cov ntshav plasma protein.

Hauv kev tshawb nrhiav tsiaj, tsis muaj kev txuam ntawm lub Cheebtsam ntawm Augmentin ® kev npaj hauv ib qho khoom hauv lub cev.

Amoxicillin, zoo li feem ntau penicillins kis mus rau niam mis. Cov kab ntawm clavulanic acid kuj tseem yuav pom nyob hauv niam cov kua mis.Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab thiab ua paug rau ntawm lub qhov ncauj mob ntawm lub qhov ncauj, tsis muaj lwm yam tsis zoo ntawm amoxicillin thiab clavulanic acid rau kev noj qab haus huv ntawm cov niam mis-pub mis paub.

Cov kev tshawb fawb tsiaj yug me nyuam tau pom tias amoxicillin thiab clavulanic acid hla qhov chaw teeb meem. Txawm li cas los xij, tsis muaj qhov tshwm sim tsis zoo ntawm tus me nyuam hauv plab.

10-25% ntawm thawj zaug koob tshuaj amoxicillin raug ntiab tawm los ntawm ob lub raum ua lub zog tsis haum rau lub cev (cov tshuaj penicilloic acid). Clavulanic acid yog dav rau 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid thiab amino-4-hydroxy-butan-2-ib thiab tau tawm ntawm cov raum Lub plab zom zaws, nrog rau cov huab cua uas tsis tas sijhawm nyob hauv daim ntawv cov roj carbon dioxide.

Zoo li lwm yam penicillins, amoxicillin tsuas yog tawm hauv cov raum, thaum clavulanic acid tawm los ntawm ob lub raum thiab ntxiv cov tshuab.

Li ntawm 60-70% ntawm amoxicillin thiab kwv yees li 40-65% ntawm clavulanic acid raug tso tawm los ntawm lub raum tsis hloov hauv thawj 6 teev tom qab noj 1 lub rooj. 250 mg + 125 mg lossis 1 ntsiav tshuaj 500 mg + 125 mg.

Kev tswj hwm tib lub sij hawm ntawm probenecid qeeb ua rau qhov kev zam ntawm amoxicillin, tab sis tsis yog clavulanic acid (saib "Kev Sib Hloov").

Kev Taw Qhia Augmentin ®

Kev sib xyaw ntawm amoxicillin nrog clavulanic acid yog qhia rau kev kho mob ntawm cov kab mob ntawm cov chaw hauv qab no tshwm sim los ntawm cov kab mob me me nkag siab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid:

cov mob ua pa sab sauv (suav nrog rau tus mob ENT), xws li ua mob tonsillitis, mob ntsws, mob otitis, feem ntau tshwm sim Tus kab mob Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 thiab Streptococcus pyogenes, (tshwj tsis yog Augmentin ntsiav tshuaj 250 mg / 125 mg),

cov kab mob ua pa tsawg dua, xws li exacerbations ntawm mob ntsws ntev, mob ntsws mob ntsws, thiab mob ntsws, feem ntau tshwm sim Kab mob ntsws Streptococcus mob ntsws, Haemophilus khaub thuas 1 thiab Moraxella catarrhalis 1,

mob txeeb zig, xws li mob cystitis, tus mob urethritis, pyelonephritis, kis mob rau poj niam lub cev ua paug, feem ntau tshwm sim los ntawm hom tsiaj hauv tsev neeg Enterobacteriaceae 1 (feem ntau yog Escherichia coli 1 ), Dab Tsi Staphylococcus saprophyticus thiab hom Enterococcusli zoo li kab mob gonorrhea tshwm sim los ntawm Neisseria gonorrhoeae 1,

daim tawv nqaij thiab cov nqaij mos muag kis mob feem ntau tshwm sim Staphylococcus aureus 1, Tus kab mob Streptococcus pyogenes thiab hom Bacteroides 1,

kis mob ntawm cov pob txha thiab pob qij txha, xws li osteomyelitis, feem ntau tshwm sim Staphylococcus aureus 1, yog tias tsim nyog, kho lub sijhawm ntev ntev yog qhov ua tau.

cov kab mob odontogenic, piv txwv li kab mob txha caj qaum, odontogenic maxillary sinusitis, mob hniav ntau heev nrog kev kis mob cellulitis (tsuas yog rau cov ntsiav tshuaj Augmentin cov ntawv, ntau npaum li 500 mg / 125 mg, 875 mg / 125 mg),

lwm cov kab mob sib xyaw (piv txwv, septic rho menyuam, tom qab sepsis, mob intraabdominal sepsis) yog ib feem ntawm kev kho mob kauj ruam (tsuas yog rau cov ntsiav tshuaj Augmentin ntau npaum 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Cov neeg sawv cev ntawm cov kab mob tsis txawv txav tsim cov beta-lactamase, uas ua rau lawv tsis raug tshuaj amoxicillin (saib. Pharmacodynamics).

Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag. Augmentin ® tseem qhia tau rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me uas tsim cov beta-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Cov kev nkag siab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av ntawd thiab sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.

Cov Yuav Tsum Muaj

Rau txhua daim ntawv qhia

cov tshuaj tiv thaiv tsis haum rau amoxicillin, clavulanic acid, lwm yam tshuaj, tshuaj tua kab mob beta-lactam (piv txwv li penicillins, cephalosporins) hauv anamnesis,

yav dhau los lub sijhawm daj ntseg lossis lub siab ua kom lub siab ua haujlwm thaum siv amoxicillin nrog clavulanic acid nyob hauv keeb kwm.

Ib qho ntxiv, rau hmoov rau kev tshem tawm qhov ncauj, 125 mg + 31.25 mg

Ib qho ntxiv, rau hmoov rau kev tshem tawm qhov ncauj, 200 mg + 28.5 mg, 400 mg + 57 mg

lub raum khiav tsis zoo (Cl creatinine tsawg dua 30 ml / min),

cov menyuam yaus hnub nyoog txog li 3 hlis.

Ntxiv rau qhov ntxig zaj duab xis ntsiav tshuaj, 250 mg + 125 mg, 500 mg + 125 mg

cov menyuam tsis tau muaj 12 xyoos lossis lub cev hnyav dua 40 kg.

Tsis tas li ntawd, rau cov ntsiav tshuaj-txheej roj, 875 mg + 125 mg

lub raum khiav tsis zoo (Cl creatinine tsawg dua 30 ml / min),

cov menyuam tsis tau muaj 12 xyoos lossis lub cev hnyav dua 40 kg.

Nrog saib xyuas: ua rau lub siab ua haujlwm tsis zoo.

Cev xeeb tub thiab lactation

Hauv kev tshawb fawb ntawm kev ua tiav tsiaj hauv tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin ® tsis ua rau muaj teebmeem teratogenic.

Hauv txoj kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev puas ua ntej, nws tau pom tias kev kho nrog prophylactic nrog Augmentin be tej zaum cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos. Zoo li txhua yam tshuaj, Augmentin ® tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog muaj kev cia siab rau tus niam tshaj qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Cov tshuaj Augmentin ® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab lossis ua paug rau ntawm cov kua qog ua rau lub qhov ncauj ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov tshuaj yeeb dej caw ntawm cov tshuaj no mus rau niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos niam mis. Thaum muaj qhov tshwm sim tsis zoo hauv cov menyuam yaus noj niam mis, kev pub mis niam yuav tsum tsis tsum.

Sab sij huam

Cov xwm txheej tsis zoo uas tau nthuav tawm hauv qab no yog teev raws li kev puas tsuaj rau cov kabmob thiab cov nruab nrog cev thiab qhov ntau zaus tshwm sim. Qhov ntau zaus ntawm qhov tshwm sim tau txiav txim siab raws li hauv qab no: ntau heev - /1 / 10, feem ntau ≥1 / 100 thiab ® thaum pib noj mov, tsis xws luag - kev zom zaub mov, tsis tshua muaj - kab mob ntsig txog tus kab mob colitis (suav nrog pseudomembranous colitis thiab hemorrhagic colitis), dub " plaub "tus nplaig, mob plab, mob plab, ua kom tawv nqaij ntawm txheej txheej txheej hniav txha hniav laus hauv cov menyuam yaus. Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob ua kom pom cov hniav, txij li txhuam koj cov hniav tau txaus.

Nyob rau ib feem ntawm daim siab thiab kais plab: tsis cuag li - ib qho kev nce ntawm ib qho txiaj ntsig ntawm AST thiab / lossis ALT. Qhov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob beta-lactam, tab sis nws qhov tseem ceeb hauv cov chaw kho mob tsis paub. Tsis tshua muaj - kab mob siab thiab mob cholestatic daj ntseg. Cov tshwm sim no tau pom nyob hauv cov neeg mob tau txais kev kho mob nrog penicillin tshuaj tua kab mob thiab cephalosporins. Kev nce siab ntawm bilirubin thiab alkaline phosphatase.

Cov kev mob tshwm sim los ntawm daim siab yog pom feem ntau hauv cov txiv neej thiab cov neeg laus laus thiab yuav cuam tshuam nrog kev kho mob mus ntev. Cov xwm txheej tsis zoo no tsis tshua pom muaj hauv cov menyuam yaus.

Cov cim npe thiab cov tsos mob feem ntau tshwm sim thaum lossis tom qab tas kev kho, tab sis qee qhov xwm txheej lawv yuav tsis tshwm sim rau ntau lub lis piam tom qab kev kho tiav. Cov xwm txheej tsis zoo yog cov thim rov qab. Kev phiv tshuaj los ntawm daim siab tuaj yeem yog qhov hnyav, muaj qee qhov tsis tshua muaj neeg ceeb toom kev ua kom tuag taus. Yuav luag txhua qhov teeb meem no, cov no yog cov neeg mob uas mob nyhav los yog cov neeg mob tau txais cov tshuaj hepatotoxic.

Ntawm ib feem ntawm daim tawv nqaij thiab cov nqaij mos subcutaneous: tsis ncaw - pob khaus, khaus, urticaria, tsis tshua muaj erythema multiforme, tsis tshua muaj Stevens-Johnson syndrome, mob ua paug rau daim tawv nqaij, ua rau mob ua paug, ua rau mob ua paug, ua paug rau tus mob txha nqaj qaum.

Yog tias muaj tawv nqaij tsis haum, kho nrog Augmentin ® yuav tsum tsis ua mus ntxiv.

Los ntawm ob lub raum thiab mob txeeb zig: muaj tsawg kawg - interstitial nephritis, crystalluria (saib "Overdose"), hematuria.

Kev sib txuam

Kev siv ua ke ib txhij ntawm cov tshuaj Augmentin ® thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin ® thiab probenecide tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid.

Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol.

Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li kev siv Augmentin thiab methotrexate ntau tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate.

Zoo li lwm yam tshuaj tua kab mob, Augmentin ® kev npaj yuav cuam tshuam rau lub plab hnyuv microflora, ua rau kev txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua haujlwm ntawm kev sib xyaw ua ke ntawm qhov ncauj.

Cov ntawv nyeem piav qhia feem ntau tsis tshua muaj neeg nce MHO hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias tsim nyog, txoj kev tswj hwm ntawm Augmentin ® npaj nrog PV anticoagulants lossis MHO yuav tsum tau ua tib zoo saib xyuas thaum sau tshuaj lossis thim kev Augmentin ® kev npaj kho kom haum rau cov tshuaj anticoagulants rau kev tswj hwm qhov ncauj.

Tsuas tshuaj thiab tswj hwm

Kev noj tshuaj rau lub cev yog tsim tshwj xeeb, nyob ntawm seb muaj hnub nyoog, hnyav lub cev, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav npaum li cas.

Txhawm rau kom txo qis lub plab zom mov tuaj yeem cuam tshuam thiab txhawm rau txhawm rau nqus kom zoo, cov tshuaj yuav tsum tau noj thaum pib noj mov. Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws yog qhov ua tau los ua cov kev kho mob stepwise (thawj kev tswj hwm kev siv tshuaj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Nws yuav tsum nco ntsoov tias 2 tab. Augmentin ®, 250 mg + 125 mg tsis sib npaug rau 1 ntsiav tshuaj. Augmentin ®, 500 mg + 125 mg.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos thiab laus dua lossis hnyav 40 kg lossis ntau dua. Nws raug nquahu kom siv 11 ml ntawm kev ncua ib ntus ntawm kev siv tshuaj ntawm 400 mg + 57 mg hauv 5 ml, uas yog sib npaug rau 1 lub rooj. Augmentin ®, 875 mg + 125 mg.

1 tab. 250 mg + 125 mg 3 zaug hauv ib hnub rau kev kis mob me me mus rau mob hnyav. Hauv kev kis mob hnyav (suav nrog mob ntsws thiab mob txeeb zig, mob ntsws thiab mob txawv txav ntawm txoj hlab ntsws), lwm txoj kev noj tshuaj ntawm Augmentin recommended raug pom zoo.

1 tab. 500 mg + 125 mg 3 zaug ib hnub.

1 tab. 875 mg + 125 mg 2 zaug ib hnub.

Cov menyuam hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua li 40 kg. Kev xam qhov tseeb yog nqa tawm raws li lub hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg / hnub lossis hauv ml ntawm kev ncua. Qhov koob tshuaj txhua hnub tau muab faib ua 3 koob tshuaj txhua 8 teev (125 mg + 31.25 mg) lossis 2 koob tshuaj txhua 12 teev (200 mg + 28.5 mg, 400 mg + 57 mg). Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.

Augmentin ® ntau npaum cov tshuaj (suav muab xam raws li amoxicillin)

Kev txhaj tshuaj qis ntawm Augmentin ® raug pom zoo rau kev kho mob ntawm daim tawv nqaij thiab cov nqaij mos, nrog rau cov mob tonsillitis.

Kev txhaj tshuaj ntau ntawm Augmentin High raug pom zoo rau kev kho mob ntawm cov kab mob xws li otitis media, sinusitis, kis mob qis qis ntawm txoj hlab ntsws thiab mob txeeb zig, mob pob txha thiab pob qij txha.

Muaj cov ntaub ntawv tshawb fawb tsis txaus kom pom zoo siv cov tshuaj Augmentin ® hauv ib koob ntau dua 40 mg + 10 mg / kg hauv 3 koob tshuaj (4: 1 ncua kev kawm) rau cov menyuam yaus hnub nyoog qis dua 2 xyoos.

Cov menyuam txij thaum yug mus txog 3 hlis. Vim lub cev tsis muaj nuj nqi ntawm qhov muaj nuj nqi zoo kawg ntawm lub raum, qhov tshuaj pom zoo ntawm Augmentin ® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.

Cov menyuam yug ntxov ntxov. Tsis muaj cov lus qhia hais txog qhov muab tshuaj.

Cov pab pawg neeg tshwj xeeb

Cov neeg laus cov neeg mob. Kev kho ntawm cov tshuaj ntau npaum li cas tsis tas yuav tsum tau ua; Hauv cov neeg mob laus uas lub raum lub raum tsis ua haujlwm, cov koob tshuaj uas tsim nyog rau cov neeg laus uas lub raum tsis ua haujlwm.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo. Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los hloov lub tswv yim hloov cov koob tshuaj hauv cov neeg mob zoo li no.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo. Kev kho ntawm cov tshuaj ntau npaum li cas yog raws li qhov siab tshaj plaws kev pom zoo ntawm amoxicillin thiab creatinine tshem tawm tus nqi.

Augmentin age ntau npaum kev noj tshuaj

Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg: Cov koob tshuaj hloov kho raws li qhov xav tau ntau tshaj plaws ntawm amoxicillin.

2 tab. 250 mg + 125 mg hauv 1 koob tshuaj txhua 24 teev

Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (1 ntsiav tshuaj) thiab lwm 1 lub tshuaj. tom kawg ntawm kev lim ntshav lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg: Cov koob tshuaj hloov kho raws li qhov xav tau ntau tshaj plaws ntawm amoxicillin.

1 tab. 500 mg + 125 mg hauv 1 koob tshuaj txhua 24 teev

Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (1 ntsiav tshuaj) thiab lwm 1 lub tshuaj. tom kawg ntawm kev lim ntshav lim ntshav (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Tus txheej txheem ntawm kev npaj ntawm qhov raug ncua

Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug. Kwv yees li 60 ml ntawm cov dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, cia lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Feem ntau, txog 92 ml dej yuav tsum npaj los txhawm rau ncua dej kom ntau li 125 mg + 31.25 mg thiab 64 ml dej rau kom haus 200 mg + 28.5 mg thiab 400 mg + 57 mg.

Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov kev ncua ntawm kev siv tshuaj Augmentin ® tuaj yeem tov nrog dej hauv qhov sib piv ntawm 1: 1.

Noj ntau dhau

Cov tsos mob tuaj yeem pom los ntawm lub plab zom mov thiab cuam tshuam hauv dej-electrolyte tshuav nyiaj li cas.

Amoxicillin crystalluria tau piav qhia, qee qhov xwm txheej ua rau txoj kev txhim kho lub raum tsis ua haujlwm (saib "Cov Lus Qhia Tshwj Xeeb").

Cov qaug dab peg hauv cov neeg mob uas lub raum tsis ua haujlwm, nrog rau cov neeg uas tau txais cov tshuaj ntau ntawm cov tshuaj.

Kev Kho Mob: Cov tsos mob los ntawm kev mob plab zom mov - kev kho mob tshwm sim, them nyiaj tshwj xeeb rau qhov ib txwm ua ntawm dej-electrolyte tshuav nyiaj li cas. Amoxicillin thiab clavulanic acid tuaj yeem tshem tawm cov ntshav tawm los ntawm hemodialysis.

Cov txiaj ntsig ntawm kev soj ntsuam ib txwm muaj nrog 51 tus menyuam nyob hauv lub chaw tso tshuaj lom tau qhia tias kev tswj hwm ntawm amoxicillin ntawm koob tshuaj tsawg dua 250 mg / kg tsis tau ua rau cov tsos mob tseem ceeb thiab tsis tas yuav ua kom mob plab.

Cov lus qhia tshwj xeeb

Ua ntej pib kho nrog Augmentin ®, nws yog ib qho tsim nyog yuav tsum sau ib qho keeb kwm kev kho mob kom zoo txog kev tiv thaiv kab mob yav dhau los rau kev siv penicillins, cephalosporins lossis lwm yam tshuaj uas ua rau muaj kev tsis haum tshuaj ntawm tus neeg mob.

Cov kev mob hnyav thiab qee zaum kuj ua rau lub cev tsis haum tus mob (anaphylactic tshua) rau penicillins tau piav qhia. Txoj kev pheej hmoo ntawm cov kev tawm tsam zoo li no yog qhov siab tshaj plaws rau cov neeg mob uas muaj keeb kwm ntawm kev tsis haum lub cev rau penicillins. Yog tias muaj qhov ua xua, nws yuav tsum tsum tsis kho nrog Augmentin ® thiab pib kho lwm txoj kev kho kom haum.

Thaum muaj kev phiv tshuaj nyhav, epinephrine yuav tsum muab rau tus neeg mob tam sim ntawd. Kev kho cov pa oxygen, kev tswj hwm kev tswj hwm ntawm GCS thiab kev pabcuam hauv airway patency, suav nrog kev nkag mus ntxiv, kuj tseem yuav tsum ua.

Yog hais tias muaj kev txhawj xeeb ntawm kev kis mob mononucleosis, Augmentin ® yuav tsum tsis txhob siv, vim hais tias nyob rau hauv cov neeg mob tus mob no, amoxicillin tuaj yeem ua rau mob pob khaus zoo li tawv nqaij ua pob, uas ua rau muaj kev cuam tshuam rau kev kuaj mob.

Kev kho mob mus ntev nrog Augmentin ® tuaj yeem ua rau muaj kev tawm tsam ntau ntawm cov kab mob tsis haum.

Feem ntau, Augmentin ® tau zam zoo thiab muaj cov yam ntxwv toxicity tsis zoo ntawm txhua tus penicillins. Thaum kho kho nrog Augmentin long lub sijhawm ntev, nws raug nquahu kom ntsuas qee lub sijhawm ua haujlwm ntawm lub raum, mob siab thiab ntshav.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj thaum noj mov.

Hauv cov neeg mob uas tau txais kev sib xyaw ntawm amoxicillin nrog clavulanic acid ua ke nrog indirect (qhov ncauj) anticoagulants, nyob rau hauv cov xwm txheej tsis tshua muaj, qhov nce hauv PV (nce hauv MHO) tau tshaj tawm. Nrog rau kev sib koom tes ntawm kev tiv thaiv kabmob (qhov ncauj) anticoagulants nrog kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev saib xyuas ntawm cov ntsuas tseem ceeb yog qhov tsim nyog. Yuav kom tswj tau qhov xav tau ntawm qhov ncauj ua kom lub ntsej muag, qhov ntau npaum yuav tsum tau hloov kho.

Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov tshuaj ntawm Augmentin ® yuav tsum tau kho raws li kev ua txhaum cai (saib "Dosage thiab administration", Cov neeg mob uas lub raum tsis ua hauj lwm zoo).

Hauv cov neeg mob nrog txo diuresis, crystalluria tsis tshua muaj tshwm sim, feem ntau nrog kev kho mob kho mob. Thaum lub sijhawm tswj hwm ntawm amoxicillin koob tshuaj ntau, nws raug nquahu kom noj cov kua txaus thiab tswj cov diuresis kom txaus los txo qhov muaj feem ntawm kev tsim cov tshuaj amoxicillin muaju (saib "Overdose").

Noj cov tshuaj Augmentin ® sab hauv ua rau cov ntsiab lus ntawm amoxicillin nyob rau hauv cov zis, uas tuaj yeem ua rau cov kev ntsuas tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis (piv txwv, Benedict test, Feling test). Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis.

Kev tu xyuas hniav yuav pab tiv thaiv kom hniav tsis txhob cuam tshuam nrog kev siv tshuaj, vim nws txaus los txhuam koj cov hniav (rau kev ncua).

Nws yog ib qho tsim nyog yuav tau siv cov tshuaj Augmentin ® tsis pub dhau 30 hnub txij li lub sijhawm qhib lub pob ntawm laminated txhuas ntawv ci (rau cov ntsiav tshuaj)

Kev quav yeeb quav tshuaj thiab quav yeeb tshuaj. Tsis pom muaj kev quav yeeb tshuaj, quav tshuaj thiab kev tsis haum tshuaj cuam tshuam nrog kev siv tshuaj Augmentin ® tau pom.

Cuam Tshuam rau kev muaj peev xwm tsav tsheb thiab ua haujlwm nrog tshuab. Txij li thaum cov tshuaj yuav ua rau kiv taub hau, nws yog ib qho tsim nyog ceeb toom rau cov neeg mob txog kev ceev faj thaum tsav tsheb lossis ua haujlwm nrog cov tshuab txav.

Daim ntawv tso tawm

Hmoov rau kev tshem tawm ntawm qhov ncauj, 125 mg + 31.25 mg hauv 5 ml. Hauv lub raj mis ntawm cov ntshiab iav, kaw los ntawm lub hau ntswj-ntawm aluminium cap nrog kev tswj ntawm thawj qhib, 11,5 g .1 fl. ua ke nrog nrog ntsuas lub hau hauv kab ntawv tuab.

Hmoov rau kev tshem tawm ntawm qhov ncauj, 200 mg + 28.5 mg hauv 5 ml, 400 mg + 57 mg hauv 5 ml. Hauv lub khob iav pob tshab kaw nrog lub hau ntswj-ntawm txhuas lub taub hau nrog kev qhib thawj tswj, 7.7 g (rau qhov ntau npaum li 200 mg + 28.5 mg hauv 5 ml) lossis 12.6 g (rau qhov ntau npaum li 400 mg + 57 mg hauv 5 ml ) 1 fl. ua ke nrog ntsuas lub ntsuas los yog lub koob txhaj tshuaj hauv lub thawv ntawv thawv.

Cov ntsiav tshuaj ua yeeb yaj kiab, 250 mg + 125 mg. Hauv aluminium / PVC blister 10 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntawv ci ntawv nyiaj ntim khoom hauv thawv ntawv thawv.

Cov ntsiav tshuaj ua yeeb yaj kiab, 500 mg + 125 mg. Hauv aluminium / PVC / PVDC blister 7 lossis 10 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntim ntawm cov ntawv ci laminated txhuas hauv thawv ntawv thawv.

Cov ntsiav tshuaj ua yeeb yaj kiab, 850 mg + 125 mg. Hauv aluminium / PVC blister 7 pcs. 1 blister nrog ib lub hnab ntawm silica gel hauv ib pob ntawm laminated txhuas ntawv ci. 2 ntawv ci ntawv nyiaj ntim khoom hauv thawv ntawv thawv.

Augmentin ® hnub tas sijhawm

zaj duab xis-coated ntsiav tshuaj 250 mg + 125 mg - 2 xyoos.

zaj duab xis-coated ntsiav tshuaj 500 mg + 125 mg - 3 xyoos.

zaj duab xis-ntsiav tshuaj 875 mg + 125 mg - 3 xyoos.

hmoov rau kev ncua rau kev tswj hwm ntawm qhov ncauj 125mg + 31.25mg / 5ml - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 200 mg + 28.5 mg / 5 ml 200 mg + 28.5 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.

hmoov rau kev ncua rau kev tswj hwm qhov ncauj 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - 2 xyoos. Qhov npaj tos tawm yog 7 hnub.

Tsis txhob siv tom qab hnub tas sij hawm qhia ntawm pob.

Zaj duab xis-coated ntsiav tshuaj los ntawm dawb mus rau yuav luag dawb, oval, nrog ib qho cim sau "AUGMENTIN" ntawm ib sab, ntawm lub kink - los ntawm daj-dawb mus rau yuav luag dawb.

TshwjxeebMagnesium stearate 6.5 mg, sodium carboxymethyl hmoov txhuv nplej siab 13 mg, colloidal silicon dioxide 6.5 mg, microcrystalline cellulose 650 mg.

Muaj pes tsawg leeg zaj duab xis plhaub: titanium dioxide - 9.63 mg, hypromellose (5cP) - 7.39 mg, hypromellose (15cP) - 2.46 mg, macrogol 4000 - 1,46 mg, macrogol 6000 - 1,46 mg, dimethicone - 0.013 mg, dej lim (tshem tawm thaum lub sijhawm ua haujlwm).

10 Pcs - hlwv (1) nrog ib lub hnab ntim ntawm silica gel - ntim ua los ntawm cov ntawv ci txhuas laminated (2) - pob ntawv los ntawm cardboard.

Cov kab mob kis tau los ntawm cov tshuaj lom neeg lub cev:

Kev kis mob ntawm cov pa sab saud thiab cov kabmob ENT (xws li mob tonsillitis, mob ntsws, mob otitis media), feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogenes,

- cov kab mob ua pa tsawg dua: exacerbations ntawm mob ntsws ntev, lobar mob ntsws thiab mob ntsws, feem ntau tshwm sim los ntawm Streptococcus pneumoniae, Haemophilus influenzae * thiab Moraxella catarrhalis * (tshwj tsis yog rau ntsiav tshuaj 250 mg / 125 mg),

Kev kis tus mob Urogenital: cystitis, urethritis, pyelonephritis, kis mob rau poj niam lub cev, ua feem ntau los ntawm hom kab mob Enterobacteriaceae tsev neeg (feem ntau Escherichia coli *), Staphylococcus saprophyticus thiab hom kab mob ntawm genus Enterococcus,

- kab mob gonorrhea los ntawm Neisseria gonorrhoeae * (tshwj tsis yog ntsiav tshuaj 250 mg / 125 mg),

- kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, feem ntau tshwm sim los ntawm Staphylococcus aureus *, Streptococcus pyogenes thiab hom ntawm lub genus Bacteroides *,

- kis kab mob ntawm cov pob txha thiab pob qij txha: osteomyelitis, feem ntau tshwm sim los ntawm Staphylococcus aureus *, yog tias tsim nyog, kev kho mob ntev,

- cov kab mob hu ua odontogenic, piv txwv li, mob qog nqaij hlav, mob ntshav tawm tsam, mob hniav ntau nrog cov mob cellulite (rau cov ntsiav tshuaj 500 mg / 125 mg lossis 875 mg / 125 mg),

- lwm qhov sib xyaw sib xyaw (piv txwv, septic rho menyuam, sepsis tom qab, mob se rau lub plab) yog ib feem ntawm kev kho mob kauj ruam (rau cov ntsiav tshuaj 250 mg / 125 mg lossis 500 mg / 125 mg, lossis 875 mg / 125 mg).

* - Cov tib neeg sawv cev ntawm cov kab mob tshwj xeeb tsim tawm β-lactamase, uas ua rau lawv tsis muaj qhov tsis haum rau amoxicillin.

Kev kis mob tshwm sim los ntawm cov kab mob me me uas nkag rau amoxicillin tuaj yeem kho nrog Augmentin ®, vim tias amoxicillin yog ib qho ntawm nws cov khoom xyaw nquag.Augmentin ® tseem qhia tau rau kev kho mob sib xyaw ua ke los ntawm cov kab mob me me nkag rau amoxicillin, nrog rau cov kab mob me me uas ua producing-lactamase, rhiab rau kev sib xyaw ntawm amoxicillin nrog clavulanic acid.

Qhov rhiab ntawm cov kab mob mus rau kev sib xyaw ua ke ntawm amoxicillin nrog clavulanic acid nws txawv nyob ntawm thaj av thiab dhau sijhawm. Qhov tsim nyog, cov ntaub ntawv hais txog qhov chaw hauv zos yuav tsum tau coj mus rau hauv qhov tsis txaus siab. Yog tias tsim nyog, kuaj cov kab mob microbiological yuav tsum tau sau thiab txheeb xyuas rau tus kab mob bacteriological rhiab.

Cov tshuaj noj rau lub cev yog tsim tshwj xeeb raws lub hnub nyoog, lub cev qhov hnyav, lub raum kev ua haujlwm ntawm tus neeg mob, nrog rau qhov mob hnyav heev.

Txhawm rau kom zoo thiab txo qis kev phiv los ntawm lub plab zom mov, Augmentin ® raug pom zoo kom noj thaum pib noj mov.

Qhov kawm tsawg kawg ntawm cov tshuaj tua kab mob yog 5 hnub.

Txoj kev kho yuav tsum tsis txhob txuas ntxiv ntev dua 14 hnub yam tsis muaj tshuaj xyuas qhov xwm txheej kho mob.

Yog tias tsim nyog, nws muaj peev xwm los ua kev kho mob staged (thaum pib txoj kev kho, kev tswj hwm kev coj ntawm cov tshuaj nrog kev hloov mus rau tom kev tswj hwm qhov ncauj).

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg lossis ntau dua

1 ntsiav tshuaj ntawm 250 mg / 125 mg 3 zaug / hnub (rau kev kis mob me txog rau mob hnyav), lossis 1 ntsiav tshuaj ntawm 500 mg / 125 mg 3 zaug / hnub, lossis 1 ntsiav tshuaj ntawm 875 mg / 125 mg 2 zaug / hnub, lossis 11 ml ntawm kev ncua ntawm 400 mg / 57 mg / 5 ml 2 zaug / hnub (uas yog sib npaug rau 1 ntsiav tshuaj ntawm 875 mg / 125 mg).

2 ntsiav tshuaj ntawm 250 mg / 125 mg tsis sib npaug rau 1 ntsiav tshuaj ntawm 500 mg / 125 mg.

Cov menyuam yaus hnub nyoog 3 hlis txog 12 xyoos nrog lub cev hnyav dua 40 kg

Cov tshuaj yog sau tseg hauv daim ntawv ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj.

Kev suav qhov ntsuas yog ua raws li hnub nyoog thiab lub cev qhov hnyav, qhia hauv mg / kg lub cev qhov hnyav / hnub (xam raws li amoxicillin) lossis hauv ml ntawm kev ncua.

Qhov ntau yam pauv ntawm qhov kev ncua 125 mg / 31.25 mg hauv 5 ml - 3 zaug / hnub txhua 8 teev

Qhov ntau yam ntawm kev ncua 200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml - 2 zaug / hnub txhua 12 teev.

Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.

Augmentin ® ntau npaum cov lus (qhov muab tshuaj rau amoxicillin)

Kev txhaj tshuaj qis ntawm Augmentin ® tau siv rau kev kho mob ntawm kev kis mob ntawm daim tawv nqaij thiab cov nqaij mos, thiab ua rau mob tonsillitis.

Kev txhaj tshuaj siab ntawm Augmentin ® yog siv los kho cov kab mob xws li otitis media, sinusitis, kis mobqis qis ua pa thiab mob txeeb zig ntawm cov pob txha thiab pob qij txha.

Tsis txaus cov ntaub ntawv soj ntsuam pom zoo kom pom zoo siv cov tshuaj Augmentin ® hauv ib koob ntau dua 40 mg / kg / hnub hauv 3 koob tshuaj (4: 1 ncua kev kawm) cov me nyuam qis dua 2 xyoos.

Cov menyuam txij thaum yug mus txog 3 hlis

Vim lub cev tsis muaj nuj nqi ntawm qhov muaj nuj nqi zoo kawg ntawm lub raum, qhov tshuaj pom zoo ntawm Augmentin ® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.

Kev siv qhov kev ncua 7: 1 (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml) tsis pom zoo rau cov neeg no.

Cov menyuam yug ua ntej

Tsis muaj cov lus qhia hais txog qhov muab tshuaj.

Cov neeg laus cov neeg mob

Tsis tas yuav txhaj ib koob. Ntawm cov neeg laus laus uas lub raum tsis zoo ua haujlwm cov koob tshuaj yuav tsum tau kho raws li cov lus qhia rau cov neeg laus uas lub raum khiav tsis zoo.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug kwv yees QC cov txiaj ntsig.

Cov neeg laus

Feem ntau, yog tias ua tau, kev kho mob rau cov niam txiv yuav tsum yog qhov zoo dua.

Cov neeg mob Hemodialysis

Kev hloov pauv koob tshuaj yog ua raws li qhov siab tshaj plaws ntawm kev tso cai ntawm amoxicillin: 2 tab. 250 mg / 125 mg hauv ib koob tshuaj txhua 24 teev, lossis 1 daim pib. 500 mg / 125 mg nyob rau hauv ib koob txhua 24 teev, lossis ncua kev ncua ntawm 15 mg / 3.75 mg / kg 1 zaug / hnub.

Ntsiav tshuaj lub sijhawm hemodialysis kev sib kho, ntxiv 1 koob tshuaj (ib ntsiav tshuaj) thiab lwm 1 koob tshuaj (ib ntsiav tshuaj) tom qab qhov kev lim ntshav tag (kom them nyiaj rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Kev Raug Ncua ua ntej kev kho mob hemodialysis, ib qho koob tshuaj ntxiv ntawm 15 mg / 3.75 mg / kg yuav tsum tau muab tshuaj. Txhawm rau kom rov qab ua kom muaj qhov kub siab ntawm cov tshuaj sib xyaw ntawm cov tshuaj Augmentin ® hauv cov ntshav, koob thib ob ntxiv ntawm 15 mg / 3.75 mg / kg yuav tsum tau siv tom qab kev kho mob hemodialysis.

Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo

Txoj kev kho yog nqa tawm nrog ceev faj, daim siab ua haujlwm tseem raug saib xyuas tsis tu ncua. Tsis muaj cov ntaub ntawv txaus los kho qhov tshuaj ntau npaum li cas hauv pawg neeg mob no.

Cov kev cai npaj rau ntawm kev npaj rau kev ncua ntawv

Qhov kev ncua yog npaj tam sim ua ntej siv thawj zaug.

Ncua (125 mg / 31.25 mg hauv 5 ml): kwv yees li 60 ml ntawm cov dej rhaub kom txias kom sov rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab muab kom txog thaum cov hmoov yaj tag, cia lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 92 ml ntawm dej yog xav tau los npaj qhov kev ncua. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug tshuaj, qhov ntsuas yuav tsum raug siv, uas yuav tsum tau ntxuav zoo nrog dej tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib rab koob uas raug ncua ntawm Augmentin ® kev npaj tuaj yeem nchuav ib nrab nrog dej.

Ncua (200 mg / 28.5 mg hauv 5 ml lossis 400 mg / 57 mg hauv 5 ml): kwv yees li 40 ml ntawm cov dej rhaub kom txias rau chav sov yuav tsum tau ntxiv rau lub raj mis hmoov, tom qab ntawd kaw lub raj mis nrog lub hau thiab co kom txog thaum cov hmoov yaj tag, cia lub raj mis sawv ntsug li 5 feeb kom ntseeg tau tias kev ua kom tiav. Tom qab ntawd ntxiv dej rau lub cim rau ntawm lub raj mis thiab co lub raj mis dua. Hauv tag nrho, kwv yees li 64 ml ntawm dej yog xav tau los npaj qhov kev ncua. Lub raj mis yuav tsum tau co kom zoo ua ntej txhua qhov kev siv. Txhawm rau kom raug qhov tseeb ntawm cov tshuaj, siv lub hau ntsuas lossis cov koob txhaj tshuaj, uas yuav tsum tau ntxuav nrog dej zoo tom qab siv txhua zaus. Tom qab kev nrawm, qhov kev ncua yuav tsum khaws cia tsis pub dhau 7 hnub hauv lub tub yees, tab sis tsis khov.

Rau cov menyuam yaus hnub nyoog qis dua 2 xyoos, kev ntsuas ib leeg ntawm qhov ncua kev ncua ntawm Augmentin ® kev npaj yuav tuaj yeem tov nrog dej nyob hauv qhov sib piv ntawm 1: 1.

Cov xwm txheej tsis zoo uas tau nthuav tawm hauv qab no yog teev raws li kev puas tsuaj rau cov kabmob thiab cov nruab nrog cev thiab qhov ntau zaus tshwm sim. Qhov ntau zaus ntawm kev tshwm sim tau txiav txim siab raws li hauv qab no: ntau zaus (/1 / 10), feem ntau (≥1 / 100, ® yuav tsum tsis ua mus ntxiv).

Los ntawm ob lub raum thiab mob txeeb zig: tsis tshua muaj tshwm sim - interstitial nephritis, crystalluria, hematuria.

- Cov tshuaj tiv thaiv tsis haum rau amoxicillin, clavulanic acid, lwm yam tshuaj, tshuaj tua kab mob beta-lactam (piv txwv li penicillins, cephalosporins) hauv anamnesis,

- Cov xwm txheej daj ntseg yav dhau los lossis lub siab ua kom lub siab ua haujlwm thaum siv amoxicillin nrog clavulanic acid nyob rau hauv anamnesis,

- menyuam yaus hnub nyoog txog 12 xyoos thiab lub cev hnyav dua 40 kg (rau ntsiav tshuaj 250 mg / 125 mg lossis 500 mg / 125 mg, lossis 875 mg / 125 mg),

- cov menyuam yaus hnub nyoog txog 3 hlis (rau hmoov rau kev npaj ncua kev kawm ntawv ntawm qhov ncauj 200 mg / 28.5 mg thiab 400 mg / 57 mg),

- lub raum tsis ua haujlwm (CC ≤ 30 ml / min) - (rau cov ntsiav tshuaj 875 mg / 125 mg, rau hmoov rau kev ncua rau kev tswj hwm qhov ncauj 200 mg / 28.5 mg thiab 400 mg / 57 mg),

- phenylketonuria (rau hmoov rau kev ncua rau kev tswj hwm qhov ncauj).

Nrog ceev faj: ua rau lub siab ua haujlwm tsis zoo.

Hauv kev tshawb nrhiav ntawm kev ua me nyuam hauv tsiaj, qhov ncauj thiab kev tswj hwm ntawm Augmentin ® tsis ua rau muaj teebmeem teratogenic.

Hauv kev tshawb fawb ib zaug hauv cov poj niam nrog lub cev ua ntej lub cev xoos xoos, nws tau pom tias prophylactic kev siv tshuaj kho mob yuav cuam tshuam nrog kev pheej hmoo ntawm necrotizing enterocolitis hauv cov menyuam mos.Zoo li txhua yam tshuaj, Augmentin ® tsis pom zoo rau siv thaum cev xeeb tub, tshwj tsis yog tias muaj kev cia siab rau tus niam tshaj qhov muaj feem yuav ua rau muaj menyuam hauv plab.

Cov tshuaj Augmentin ® tuaj yeem siv thaum pub mis. Dhau ntawm qhov muaj peev xwm ntawm kev tsim muaj mob raws plab lossis ua paug rau ntawm cov kua qog ua rau lub qhov ncauj ua kab mob cuam tshuam nrog kev nkag mus ntawm cov nyiaj ntawm cov tshuaj yeeb dej caw ntawm cov tshuaj no mus rau niam mis, tsis muaj lwm yam kev tsis zoo tshwm sim hauv cov menyuam mos niam mis. Thaum muaj qhov tshwm sim tsis zoo hauv cov menyuam yaus noj niam mis, kev pub mis niam yuav tsum tsis tsum.

Cov neeg mob uas lub raum tsis ua hauj lwm zoo

Kev hloov pauv koob yog nce raws li qhov siab tshaj plaws uas tau pom zoo ntawm amoxicillin thiab raug kwv yees QC cov txiaj ntsig.

Cov neeg laus

Feem ntau, yog tias ua tau, kev kho mob rau cov niam txiv yuav tsum yog qhov zoo dua.

Cov neeg loj thiab menyuam yaus hnub nyoog 12 xyoos lossis hnyav dua 40 kg ntawm hemodialysis

Kev txhaj tshuaj ntau yog ua raws li qhov siab tshaj plaws ntawm kev tso cai ntawm amoxicillin: 1 tab. 500 mg + 125 mg hauv ib koob tshuaj txhua 24 teev lossis 2 ntsiav tshuaj. 250 mg / 125 mg nyob rau hauv ib koob tshuaj txhua 24 teev, lossis 500 mg / 125 mg (20 ml ntawm kev ncua ntawm ib koob 125 mg / 31.25 mg hauv 5 ml) 1 zaug / hnub.

Thaum lub sijhawm lim ntshav, ib qho ntxiv 1 koob tshuaj (ib ntsiav tshuaj) thiab lwm lub ntsiav tshuaj tom kawg ntawm kev lim ntshav lim ntshav (kom them rau qhov txo qis ntshav ntau ntawm amoxicillin thiab clavulanic acid).

Cov me nyuam qis dua 12 xyoos

Cov tshuaj yog sau tseg hauv daim ntawv ntawm kev ncua rau kev tswj hwm ntawm qhov ncauj.

Kev suav ntawm qhov koob tshuaj yog ua tiav raws hnub nyoog thiab qhov hnyav, qhia hauv mg / kg ntawm lub cev qhov hnyav ib hnub (xam raws li amoxicillin) lossis hauv milliliters ntawm kev ncua.

Cov menyuam yaus hnyav 40 kg lossis ntau dua cov koob tshuaj tib yam li cov neeg laus yuav tsum tau sau tseg.

Cov menyuam txij thaum yug mus txog 3 hlisCov. Vim lub cev tsis muaj nuj nqi ntawm qhov muaj nuj nqi zoo kawg ntawm lub raum, qhov tshuaj pom zoo ntawm Augmentin ® (xam rau amoxicillin) yog 30 mg / kg / hnub hauv 2 faib koob tshuaj 4: 1.

Kev siv ntawm 7: 1 ncua kev kawm ntawv hauv cov neeg no tsis pom zoo.

Cov menyuam yaus hnub nyoog 3 hlis txog 12 xyoos. Cov tshuaj pom zoo ntau npaum li cas thiab kev tswj hwm pes tsawg zaus raug nthuav tawm hauv cov kab hauv qab no.

Augmentin ® ntau npaum cov lus (qhov muab tshuaj rau amoxicillin)

Kev txhaj tshuaj qis ntawm Augmentin ® tau siv rau kev kho mob ntawm kev kis mob ntawm daim tawv nqaij thiab cov nqaij mos, thiab ua rau mob tonsillitis.

Kev txhaj tshuaj siab ntawm Augmentin ® yog siv los kho cov kab mob xws li otitis media, sinusitis, kis mobqis qis ua pa thiab mob txeeb zig.

Muaj cov ntaub ntawv soj ntsuam tsis txaus kom pom zoo siv tshuaj Augmentin ® hauv ib koob ntau dua 40 mg / kg / hnub hauv 3 koob tshuaj (4: 1 ncua kev kawm) lossis 45 mg / kg / hnub hauv 2 faib koob tshuaj (7: 1 ncua kev kawm) cov me nyuam qis dua 2 xyoos.

Ua ntej pib kho nrog Augmentin ®, nws yog ib qho tsim nyog yuav tsum tau sau ib qho keeb kwm kev kho mob kom zoo hais txog kev ua kom lub siab ntev dhau los rau kev siv penicillins, cephalosporins lossis lwm yam kev ua xua.

Cov mob hnyav, thiab qee zaum kuj ua rau neeg tuag taus, ua kom lub cev tsis haum tshuaj (qhov tsis haum tshuaj muaj txiaj ntsig) rau cov penicillins tau piav qhia. Txoj kev pheej hmoo ntawm cov kev tawm tsam zoo li no yog qhov siab tshaj plaws rau cov neeg mob uas muaj keeb kwm ntawm kev tsis haum lub cev rau penicillins. Yog tias muaj qhov ua xua, nws yuav tsum tsum tsis kho nrog Augmentin ® thiab pib kho lwm txoj kev kho kom haum. Yog tias muaj teeb meem rau qhov mob nyhav dhau los, yuav tsum muab tshuaj rau epinephrine sai sai. Kev kho cov pa oxygen, kev tswj hwm kev tswj hwm ntawm GCS thiab kev pabcuam hauv airway patency, suav nrog kev nkag mus ntxiv, kuj tseem yuav tsum ua.

Kev teem sijhawm tshuaj Augmentin ® tsis pom zoo rau qee qhov kev xav tias kis tau tus mob mononucleosis, vim tias nyob hauv cov neeg mob tus mob no, amoxicillin tuaj yeem ua rau mob pob khaus zoo li pob khaus, uas ua rau cuam tshuam kev kuaj mob tus kab mob.

Kev kho mob mus ntev nrog Augmentin ® qee zaum ua rau muaj kev tawm tsam ntau ntawm cov kab mob tsis haum.

Feem ntau, Augmentin ® tau zam zoo thiab muaj cov yam ntxwv toxicity tsis zoo ntawm txhua tus penicillins.

Thaum kho kho nrog Augmentin long lub sijhawm ntev, nws raug nquahu kom ntsuas qee lub sijhawm ua haujlwm ntawm lub raum, mob siab thiab ntshav.

Txhawm rau kom txo qis kev phiv los ntawm kev mob plab hnyuv, cov tshuaj yuav tsum noj thaum noj mov.

Hauv cov neeg mob uas tau txais kev sib xyaw ntawm amoxicillin nrog clavulanic acid ua ke nrog indirect (qhov ncauj) anticoagulants, nyob rau hauv cov xwm txheej tsis tshua muaj, kev nce prothrombin lub sijhawm (nce hauv MHO) tau tshaj tawm. Nrog rau kev sib koom tes ntawm kev tiv thaiv kabmob (qhov ncauj) anticoagulants nrog kev sib xyaw ntawm amoxicillin nrog clavulanic acid, kev saib xyuas ntawm cov ntsuas tseem ceeb yog qhov tsim nyog. Yuav kom tswj tau qhov xav tau ntawm qhov ncauj ua kom lub ntsej muag, qhov ntau npaum yuav tsum tau hloov kho.

Hauv cov neeg mob uas lub raum tsis ua haujlwm, qhov tshuaj ntawm Augmentin ® yuav tsum raug txo kom tsawg.

Hauv cov neeg mob uas txo qis diuresis, feem ntau tsis tshua muaj, kev loj hlob ntawm crystalluria tau tshaj tawm, feem ntau nrog kev siv tshuaj yaj yeeb. Thaum lub sijhawm tswj hwm ntawm amoxicillin koob tshuaj ntau, nws raug nquahu kom noj cov kua txaus thiab tswj cov diuresis kom txaus los txo qhov muaj feem ntawm kev tsim cov amoxicillin muaju.

Noj cov tshuaj Augmentin ® sab hauv ua rau cov ntsiab lus ntawm amoxicillin nyob rau hauv cov zis, uas tuaj yeem ua rau cov kev ntsuas tsis zoo hauv kev txiav txim siab cov piam thaj hauv cov zis (piv txwv, kev kuaj Benedict, ib qho kev sim Feling). Hauv qhov no, nws raug nquahu kom siv cov txheej txheem glucose oxidant rau kev txiav txim siab cov ntsiab lus ntawm cov piam thaj hauv cov zis.

Kev tu xyuas hniav yuav pab tiv thaiv kom tsis txhob ua kom pom cov hniav, txij li txhuam koj cov hniav tau txaus.

Cov ntsiav tshuaj yuav tsum tau siv tsis pub dhau 30 hnub txij li lub sijhawm qhib pob ntawm laminated lev ntawv ci.

Kev quav yeeb quav tshuaj thiab quav yeeb tshuaj

Tsis pom muaj kev quav yeeb tshuaj, quav tshuaj thiab kev tsis haum tshuaj cuam tshuam nrog kev siv tshuaj Augmentin ® tau pom.

Cuam tshuam rau kev muaj peev xwm tsav tsheb thiab tswj cov tshuab

Txij li thaum cov tshuaj yuav ua rau kiv taub hau, nws yog ib qho tsim nyog ceeb toom rau cov neeg mob txog kev ceev faj thaum tsav tsheb lossis ua haujlwm nrog cov tshuab txav.

Cov tsos mob lub plab zom mov thiab dej-electrolyte tsis txaus yuav tshwm sim. Amoxicillin crystalluria tau piav qhia, hauv qee kis ua rau kev loj hlob ntawm lub raum tsis ua haujlwm.

Qhov ncauj keev tuaj yeem tshwm sim rau cov neeg mob uas lub raum lub raum tsis ua haujlwm, nrog rau cov neeg uas tau txais tshuaj ntau heev.

Kev Kho Mob: mob plab zom mov - kev kho tus mob, nrog rau kev tshwj xeeb kom ib txwm ua dej-electrolyte sib npaug. Yog tias muaj kev noj ntau dhau, amoxicillin thiab clavulanic acid tuaj yeem tshem tawm cov ntshav tawm los ntawm hemodialysis.

Cov txiaj ntsig ntawm kev soj ntsuam ib txwm muaj nrog 51 tus menyuam ntawm lub chaw tso tshuaj lom tau qhia tias kev tswj hwm ntawm amoxicillin ntawm koob tshuaj tsawg dua 250 mg / kg tsis tau ua rau cov tsos mob tseem ceeb thiab tsis tas yuav ua kom mob plab.

Kev siv ua ke ib txhij ntawm cov tshuaj Augmentin ® thiab probenecid tsis pom zoo. Probenecid txo cov tubular ua ke ntawm amoxicillin, thiab yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin ® thiab probenecide tuaj yeem ua rau nce ntxiv thiab mob siab rau hauv cov ntshav concentration ntawm amoxicillin, tab sis tsis muaj clavulanic acid.

Kev siv tib txhij ntawm allopurinol thiab amoxicillin tuaj yeem ua rau muaj kev pheej hmoo ntawm cov tawv nqaij ua xua. Tam sim no, tsis muaj cov ntaub ntawv hauv cov ntawv sau ntawm kev siv tib lub sijhawm ntawm kev sib xyaw ntawm amoxicillin nrog clavulanic acid thiab allopurinol.

Penicillins tuaj yeem ua kom qeeb ntawm kev siv tshuaj methotrexate los ntawm lub cev los ntawm kev txwv tsis pub nws cov tubular tso pa, yog li ntawd, tib lub sijhawm siv cov tshuaj Augmentin ® thiab methotrexate tuaj yeem ua rau kom muaj kuab lom ntawm methotrexate.

Zoo li lwm yam tshuaj tua kab mob, Augmentin ® kev npaj yuav cuam tshuam rau lub plab hnyuv microflora, ua rau kev txo qis ntawm cov tshuaj estrogen los ntawm kev mob plab thiab txo qis kev ua haujlwm ntawm kev sib xyaw ua ke ntawm qhov ncauj.

Cov ntawv nyeem piav qhia feem ntau tsis tshua muaj neeg nce MHO hauv cov neeg mob uas siv cov acenocumarol lossis warfarin thiab amoxicillin. Yog tias nws tsim nyog yuav tsum tau sau ib txhij rau Augmentin ® nrog cov tshuaj tiv thaiv kab mob, lub sijhawm prothrombin lossis MHO yuav tsum ua tib zoo saib xyuas thaum kho lossis hloov Augmentin ®, kev kho tshuaj tiv thaiv tshuaj rau cov tshuaj tiv thaiv rau qhov ncauj yuav tsum tau ua.

Cov tshuaj yog ntawv yuav tshuaj.

Cov tshuaj yuav tsum muab cia rau hauv qhov chaw qhuav kom tsis txhob nkag tau rau cov menyuam yaus ntawm qhov kub tsis siab tshaj 25 ° C. Lub txee lub neej ntawm cov ntsiav tshuaj (250 mg + 125 mg) thiab (875 mg + 125 mg) yog 2 xyoos, ntsiav tshuaj (500 mg + 125 mg) - 3 xyoos. Lub txee lub neej ntawm cov hmoov rau kev npaj qhov kev ncua hauv lub raj mis tsis tau qhib yog 2 xyoos.

Qhov npaj ncua yuav tsum muab tso rau hauv tub yees ntawm qhov kub ntawm 2 ° txog 8 ° C rau 7 hnub.

Thaum koj tau txais tshuaj ntawm lub tsev muag tshuaj, lub tsev muag tshuaj tuaj yeem thov daim ntawv yuav tshuaj!