Vipidia analogue ntsiav tshuaj > Kev khomob thiab kev tiv thaiv

Vipidia (ntsiav tshuaj) Ntsuas: 183

Chaw tsim tshuaj paus: Yog tau meej
Cov Ntawv Tso Tawm:

Tab. 12,5 mg, 28 pcs., Nqe los ntawm 973 rubles
Tab. 25 mg, 28 pcs., Nqe los ntawm 1282 rubles

Vipidia cov nqi hauv cov khw muag tshuaj online
Cov lus qhia rau kev siv

Vipidia yog tus neeg sawv cev hypoglycemic hauv ntsiav tshuaj nrog alogliptin. Muab kev txo qis hauv glycosylated hemoglobin thiab piam thaj. Nws yog qhia nyob rau hauv cov ntaub ntawv ntawm hom 2 mob ntshav qab zib mellitus nyob rau hauv daim ntawv ntawm monotherapy, zoo li nyob rau hauv kev sib txuas ua ke nrog kev kho mob nrog lwm tus neeg mob ntshav qab zib. Cov tshuaj noj zoo yog 25 mg / hnub, noj tsis hais zaub mov dab tsi. Contraindicated nyob rau hauv cov kab mob ntshav qab zib ketoacidosis, yam 1 mob ntshav qab zib mellitus, mob plawv heev rau lub plawv tsis ua hauj lwm, lub raum thiab lub siab ua haujlwm. Cov mob tshwm sim tuaj yeem suav cov mob taub hau, mob rau hauv epigastrium, tawm pob, ua mob rau kis ntawm ENT plab hnyuv siab raum. Cov menyuam yaus hnub nyoog qis dua 18 xyoo thiab poj niam cev xeeb tub tsis tau raug samfwm vim tias tsis muaj cov ntaub ntawv ntawm daim ntawv thov.

Cov tshuaj ntawm cov tshuaj Vipidia

Cov analogue yog pheej yig dua los ntawm 863 rubles.

Chaw tsim tshuaj paus: Merck Sante SAA.S. (Fab Kis)
Cov Ntawv Tso Tawm:

Ntsiav tshuaj 500 mg, 30 pcs., Nqe los ntawm 110 rubles
Ntsiav tshuaj 1000 mg, 30 pcs., Nqe los ntawm 185 rubles

Glucophage tus nqi hauv cov khw muag online
Cov lus qhia rau kev siv

Fab kis tshuaj kho tus mob ntshav qab zib hom 2. Muag hauv cov ntsiav tshuaj muaj txog 500 txog 1000 mg ntawm metformin ua cov tshuaj tiv thaiv kab mob ib leeg. Muaj contraindications, yog li ntawd, ua ntej noj Glucofage, nws yog qhov yuav tsum tau sab laj nrog tus kws tshaj lij.

Cov analogue yog pheej yig dua los ntawm 182 rubles.

Chaw tsim tshuaj paus: Novartis (Switzerland)
Cov Ntawv Tso Tawm:

Ntsiav tshuaj 50 mg, 28 pcs., Nqe los ntawm 791 rubles
Ntsiav tshuaj 1000 mg, 30 pcs., Nqe los ntawm 185 rubles

Galvus cov nqi hauv cov khw muag tshuaj online
Cov lus qhia rau kev siv

Galvus yog ntsiav tshuaj npaj rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus raws li vildagliptin hauv ib koob tshuaj ntawm 50 mg. Nws tuaj yeem raug txiav txim siab ob qho tib si li monotherapy thiab ua ib feem ntawm kev sib xyaw ua ke thaum tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab tawm dag zog.

Cov analogue yog pheej yig dua los ntawm 795 rubles.

Chaw tsim tshuaj paus: Hemofarm A.D. (Serbia)
Cov Ntawv Tso Tawm:

Tab. 500 mg, 60 pcs., Nqe txij li 178 rubles
Ntsiav tshuaj 1000 mg, 30 pcs., Nqe los ntawm 185 rubles

Metformin cov nqi hauv cov khw muag tshuaj online
Cov lus qhia rau kev siv

Metformin yog ib qho tshuaj Serbian hypoglycemic rau kev siv sab hauv. Cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj muaj cov khoom xyaw nquag ntawm tib lub npe hauv tshuaj ntau npaum 500 lossis 850 mg. Nws yog tshuaj rau kev kho mob ntshav qab zib hom 2 (hauv cov neeg laus), tshwj xeeb yog cov muaj rog.

Cov analogue kim dua los ntawm 799 rubles.

Chaw tsim tshuaj paus: Bristol Myers Squibb (TEB CHAWS USA)
Cov Ntawv Tso Tawm:

5 mg ntsiav tshuaj, 30 pcs., Nqe los ntawm 1772 rubles
Ntsiav tshuaj 1000 mg, 30 pcs., Nqe los ntawm 185 rubles

Cov nqi rau Onglisa hauv cov khw muag tshuaj online
Cov lus qhia rau kev siv

Onglisa yog ib hom tshuaj siv tshuaj Asmeskas rau kev kho mob hom 2 mob ntshav qab zib mellitus raws li saxagliptin hauv tshuaj ntau npaum li 2.5 lossis 5 mg. Nws yog tshuaj ntxiv rau kev tawm dag zog lub cev thiab kev noj haus kom txhim kho glycemic tswj.

Cov analogue kim dua los ntawm 1236 rubles.

Chaw tsim tshuaj paus: Merck ntse thiab Dome (TEB CHAWS USA)
Cov Ntawv Tso Tawm:

Ntsiav tshuaj 100 mg, 28 pcs., Nqe los ntawm 2209 rubles
Ntsiav tshuaj 1000 mg, 30 pcs., Nqe los ntawm 185 rubles

Cov nqi rau Januvia hauv cov khw muag tshuaj online
Cov lus qhia rau kev siv

Januvia yog tshuaj yeeb tshuaj Asmeskas mob ntshav qab zib. Lub cev nquag ua haujlwm: sitagliptin (hauv daim ntawv ntawm phosphate monohydrate) 100 mg. Nws tuaj yeem siv los ua ntxiv rau kev tawm dag zog lub cev thiab kev noj haus kom tswj tau ntshav qab zib.

Cov analogue yog kim dua los ntawm 675 rubles.

Chaw tsim tshuaj paus: Beringer Ingelheim (Austria)
Cov Ntawv Tso Tawm:

5 mg ntsiav tshuaj, 30 pcs., Nqe los ntawm 1648 rubles
Ntsiav tshuaj 1000 mg, 30 pcs., Nqe los ntawm 185 rubles

Cov nqi rau Trazhenta hauv cov khw muag tshuaj online
Cov lus qhia rau kev siv

Trazhenta - ib qho tshuaj Austrian npaj rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus, tuaj yeem raug tshuaj ob qho tib si li mono- thiab ua ib feem ntawm kev sib xyaw ua ke. Cov tshuaj tiv thaiv tsuas yog nyob rau hauv cov muaj pes tsawg leeg yog linagliptin hauv ib qhov tshuaj ntawm 5 mg. Trazenta tsis raug tshuaj rau ntshav qab zib hom 1, thaum cev xeeb tub, lactation, zoo ib yam li muaj rau menyuam yaus hnub nyoog qis dua 18 xyoo.

Vipidia: cov lus qhia rau kev siv, nqe, xyuas thiab analogues

Vipidia yog cov tshuaj uas siv raws li cov lus qhia rau kev siv hauv ntshav qab zib. Cov neeg mob uas tau kuaj pom no yuav tsum tau soj ntsuam cov ntshav qabzib tas li kom tsis tu ncua, thiab yog tias nws tsis txaus, tom qab ntawd noj tshuaj.

Tso tawm daim ntawv, muaj pes tsawg leeg thiab ntim khoom

Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm oval ntsiav tshuaj coated nrog ib zaj duab xis daim nyias nyias. Muab:

12,5 mg - daj ntsiav tshuaj
25 mg - ib lub zas liab.

Cov khoom muag yog muag hauv cardboard ntim. Kev ntim: 4 lub blisters, muaj 7 ntsiav tshuaj, tag nrho 28 daim hauv ib pob.

Cov tshuaj nquag siv ntawm cov tshuaj yog alogliptin. Ntu:

magnesium stearate,
croscarmellose sodium,
microcrystalline cellulose,
Kev Hyprolose

Zaj duab xis txheej ntawm cov ntsiav tshuaj muaj:

hypromellose,
hlau oxide zas
titanium dioxide
macrogol
grey number case F1

Pharmacological kev ua

Alogliptin yog qhov muaj zog heev xaiv dipeptidyl peptidase-4 inhibitor. DPP-4 yog lub enzyme tseem ceeb uas ua rau muaj kev cuam tshuam sai heev ntawm cov tshuaj hormones ntawm tsev neeg incretin.

Hauv tshwj xeeb, nws yog cov tshuaj glucose-tiv thaiv insulinotropic polypeptide (HIP) thiab glucagon zoo li peptide-1 (GLP-1). Cov tshuaj hormones no ua nyob rau hauv cov hnyuv, thiab lawv qib tau sib txawv nyob ntawm cov zaub mov noj.

Qhov cuam tshuam ntawm HIP thiab GLP-1 yog rau kev ua kom muaj zog ntawm cov tshuaj insulin ncaj qha rau hauv lub txiav

Glucagon-zoo li peptide pab txo cov glucagon thiab qeeb kev tsim cov piam thaj hauv daim siab.

Nrog rau kev hloov pauv ntawm cov theem ntawm incretins nyob rau hauv kev cuam tshuam ntawm alogliptin, insulin ntau lawm nce thiab glucagon tsawg dua nrog nce qab zib.

Hauv cov neeg muaj ntshav qab zib, cov kev hloov pauv no ua rau muaj kev hloov kho glycosylated hemoglobin thiab lwm cov ntshav ua ntej thiab tom qab noj mov.

Cov Tshuaj Pharmacokinetics

Cov tshuaj yog cuam tshuam zoo rau tus neeg muaj kev noj qab haus huv thiab tus neeg mob ntshav qab zib. Alogliptin yog nqus hauv lub cev los ntawm yuav luag 100%, tsis hais los ntawm cov zaub mov noj. Nrog ib ntsiav tshuaj nkaus xwb, cov tshuaj ua kom muaj zog sai sai rau hauv cov ntshav, qhov twg tom qab 1 txog 2 teev cov tshuaj siab tshaj plaws tau ua tiav.

Alogliptin nyhav rau kev ua kom zoo hauv cov ntaub so ntswg. Kev sib raug zoo nrog cov protein ntshav yog kwv yees li 20-30%.

Nrog lub sijhawm ntev ntawm kev siv tshuaj, cov tsub zuj zuj ntawm cov roj ntsha hauv lub cev, raws li cov ntaub ntawv tshawb fawb, tsis pom nyob hauv cov neeg muaj kev noj qab haus huv lossis neeg muaj mob.

Hauv 21 teev tom qab noj tshuaj, 70% ntawm cov tshuaj yog cov kua ntshav tawm hauv lub raum hauv daim ntawv tsis hloov pauv, 13% los ntawm cov hnyuv.

Vipidia yog tsim rau mob ntshav qab zib hom 2. Lub cuab yeej ua tau zoo pab cov neeg mob, txawm tias tsis ua raws li kev noj haus thiab tsis muaj kev ua kom lub cev muaj zog. Cov tshuaj muaj peev xwm siv tau ua kev kho mob monotherapy. Koj tuaj yeem haus nws ua ke nrog lwm cov tshuaj uas pab txo qis cov piam thaj hauv cov ntshav.

Cov Yuav Tsum Muaj

Zoo li txhua yam tshuaj, Vipidia nws muaj nws cov kev txwv. Nyeem cov lus kom zoo.

Cov tshuaj yuav tsum tsis txhob qog nrog:

ua kom lub cev tsis haum rau lub cev mus rau ib qho yeeb tshuaj uas yog ib feem ntawm qhov tshuaj,
ntshav qab zib hom 1
mob ketoacidosis,
mob plawv tsis ua hauj lwm
daim siab mob siab rau,
cev xeeb tub thiab lactation,
cov me nyuam hnub nyoog qis dua 18 xyoo

Nrog ceev faj thaum:

pancreatitis
mob raum tsis ua hauj lwm,

Cov lus qhia rau kev siv (ntau npaum)

Vipidia yuav tsum noj qhov ncauj, ob qho tib si ua ntej thiab tom qab noj mov. Nws raug nquahu kom siv tsis tshaj 25 mg rau ib hnub. Nws yog qee zaum sau tseg hauv kev sib xyaw nrog lwm cov tshuaj, xws li:

Nrog kev sib koom tes ntawm Vipidia nrog metformin lossis thiazolidinedione, qhov koob tshuaj tsis hloov. Txhawm rau tshem tawm cov kev pheej hmoo ntawm hypoglycemia, thaum cov tshuaj tau raug txiav txim ib txhij nrog insulin, nws yog ib qho tsim nyog los txo cov tshuaj ntawm tom kawg. Yog tias qee yam vim koj tsis nco qab haus tshuaj, koj yuav tsum kho nws kom sai li sai tau. Tab sis tib lub sij hawm yuav tsum tsis txhob noj ob npaug.

Sab sij huam

Muaj qee lub sijhawm thaum muaj cov tsos mob tsis zoo txaus vim yog Vipidia noj tshuaj. Tus neeg mob yuav yws txog:

mob taub hau
ua pa tau kab mob
nasopharyngitis,
mob hauv lub plab
khaus thiab tawv nqaij ua pob,
kev loj hlob ntawm pancreatitis,
tsim kev raum tsis ua haujlwm.

Yog tias pom cov cim ceeb toom no, koj yuav tsum qhia koj tus kws kho mob. Tsuas yog nws tuaj yeem txiav txim siab txuas ntxiv kev kho mob nrog tshuaj lossis tsis tsim nyog. Kev mob siab rau kev qhia ntawm cov tsos mob saum toj no yuav tsum tau tshem tawm sai ntawm cov tshuaj.

Noj ntau dhau

Kev huam yuaj ntau dhau tsis ua rau muaj kev hem thawj rau tib neeg. Kev pab ntawm tus kws kho mob tsuas yog xav tau thaum muaj kev tsis haum rau Vipidia lossis thaum noj tshuaj los ntawm tib neeg kev txom nyem los ntawm cov kab mob uas muaj nyob rau hauv daim ntawv ntawm contraindications. Thawj qhov kev pab rau noj ntau dhau - pais plab lavage.

Cov lus qhia tshwj xeeb

Kev siv cov tshuaj Vipidia nrog cov insulin thiab lwm yam tshuaj uas txo cov ntshav qab zib kom yuav tsum tau kho ntau npaum li cas los txhawm rau tiv thaiv kev txhim kho ntshav qab zib. Raws li kev tshawb fawb hauv chav kho mob, kev sib cuam tshuam ntawm alogliptin nrog lwm cov khoom siv kho mob qhia tsis muaj kev hloov pauv hais tawm.

Alogliptin cuam tshuam ntau rau lub cev, yog li thaum kho koj yuav tsum tsis kam haus cawv.

Cov yeeb tshuaj "Vipidia" tsis ua rau nkees nkees, yog li tsav tsheb thiab lwm yam dej num uas yuav tsum muaj qhov kub siab ntxiv ntawm kev saib xyuas tsis raug txwv.

Tseem Ceeb: kev tshawb fawb pom tau tias cov tshuaj tsis cuam tshuam rau daim siab, ib nrab ua txhaum nws lub luag haujlwm. Mus txog thaum pom tias mob hnyav tiaj tiaj yuav tshwm sim. Yog li, ua ntej siv cov tshuaj, nws yog qhov yuav tsum tau soj ntsuam tag nrho thiab sib piv txhua yam zoo thiab tsis zoo.

Vim tias tsis muaj cov ntaub ntawv hais txog cov kev mob tshwm sim thaum cev xeeb tub thiab lactation, nws zoo dua tsis haus Vipidia.

Cov menyuam yaus thiab hnub nyoog laus

Kev muab tshuaj rau cov menyuam yaus thiab cov neeg hluas hnub nyoog qis dua 18 xyoo yog contraindicated, vim tias tsis muaj cov ntaub ntawv tshawb fawb hauv lub hnub nyoog no.

Cov neeg mob uas laus dua 60 xyoo tuaj yeem haus "Vipidiya". Cov tshuaj ntau npaum li cas tsis tas yuav raug kho. Txawm li cas los xij, nws yuav tsum tau yug los rau hauv lub siab tias qhov tshwm sim ntawm qhov kev txo qis hauv kev ua haujlwm ntawm lub raum thiab mob siab yog nyob ntawm qhov tsim los ntawm alogliptin.

Cov lus thiab cov xwm txheej ntawm kev cia

Khaws cov tshuaj hauv qhov chaw tsaus, txias qhov chaw kom deb ntawm cov menyuam yaus. Lub sij hawm ntawm kev siv yog peb xyoos txij li hnub pib. Hnub ntawm kev tsim khoom yog affixed rau ntim. Cov tshuaj uas tag sijhawm yuav txwv.

Tus nqi ntawm Vipidia hauv cov khw muag tshuaj nws txawv nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj thiab thaj av ntawm chaw nyob. Qhov nruab nrab, nws yog 845 - 1390 rubles.

Piv nrog analogues

Yog tias muaj qee yam vim li cas cov tshuaj tsis haum tus neeg mob, tus kws kho mob tab tom nrhiav tshuaj uas tuaj yeem hloov tau.

Daim ntawv teev cov tshuaj analogues ntawm cov tshuaj "Vipidia":

Npe	Cov txiaj ntsig	Nyias tsis zoo	Nqi
Galvus Met	Ib txoj hauv kev zoo los txo cov ntshav qab zib kom tsawg. Nws tseem yuav pab kom tshem tawm cov phaus ntxiv tsis tas yuav tsum ua zaub mov noj.	Cov npe loj ntawm cov kev mob tshwm sim. Tus nqi siab ntawm cov tshuaj.	Los ntawm 780 rubles.
Alogliptin	Pab normalize cov piam thaj. Tsis ua rau muaj cov metabolism hauv lub cev ntau ntxiv. Nws tsis nthuav tawm, yog ua tiav tawm hauv lub cev.	Nws tsis tuaj yeem siv rau pathologies ntawm ob lub raum, mob siab, txiav tawv nqaij. Cov tshuaj yuav tsis pheej yig.	Los ntawm 845 rubles.
Januvia	Txhawb nqa poob phaus, txo qhov qab los noj mov, ua kom ntshav tsis ua haujlwm.	Tus nqi. Muaj ntau ntau cov lus qhia siv rau kev siv, yog li nws yog ib qho tseem ceeb uas tus kws kho mob tau sau tshuaj rau.	Los ntawm 1350 rubles

Feem ntau cov lus teb los ntawm cov neeg mob ntshav qab zib tau noj Vipidia yog qhov zoo. Cov ntsiav tshuaj no muaj txiaj ntsig txo cov ntshav qabzib, zoo rau lub siab, tab sis lawv yuav tsum siv nkaus xwb raws li kws kho mob pom zoo. Cov neeg tsis nyiam qhov tseeb tias cov tshuaj muaj nqi kim. Nov yog qee qhov kev txheeb xyuas tiag:

Kuv tau kuaj mob ntshav qab zib 5 xyoo dhau los. Nws tau sau npe nrog tus kws kho mob endocrinologist, haus ntau yam tshuaj. Tab sis ob peb lub lis piam dhau los, qab zib pib nce mus txog 18 units. Tus kws kho mob sau ntawv rau kuv Vipidia. Kuv noj tsuas yog ib ntsiav tshuaj ib hnub, qab zib yog ib txwm. Kuv txaus siab heev. Kuv tus kheej pom hauv cov tshuaj no tsuas yog ib qho zoo.

Vipidia hloov cov insulin zoo heev. Thiab hauv kev sib piv nrog nws, lub cuab tam tsuas xav tau noj ib zaug ib hnub. Tsis tsim nyog yuav tau noj zaub noj mov. Kuv muaj ntshav qab zib, cov ntsiav tshuaj normalize cov piam thaj hauv cov ntshav, yog li kuv twb tsis kam insulin ntev. Qhov tseeb nws tsis meej pem rau nqe, tshuaj tsis pheej yig, tsis yog txhua tus muaj peev xwm them taus. Tab sis, ntawm chav kawm, muaj pluses. Kuv pom zoo kom txhua tus.

Kuv muaj ntshav qab zib hom 2. Nws raug kho, siv tshuaj yeeb txhua hnub, tab sis cov piam thaj tom qab ntawd poob qis, tom qab ntawd rov nce mus txog 12 pawg. Muaj cov mob ntawm kev tsis haum ntshav ntau, ua rau muaj qab zib poob ntau.

Tus kws kho mob sau ntawv rau kuv Vipidia. Kuv zoo siab nrog tshuaj. Kuv haus tsuas yog ib ntsiav tshuaj thaum sawv ntxov thiab txhua yam yog qhov qub. Txawm hais tias kim, tab sis kuv tsis saib pom kev hloov pauv hauv cov ntshav thiab tsis ntshai txhua hnub.

Tus kws kho mob muab tshuaj rau kuv rau kev yuav lub tshuaj "Vipidia". Kuv muaj ntshav qab zib tau ntau xyoo. Kuv nyiam cov tshuaj, nws txo qis qis qab zib qhia tau zoo. Kuv haus tsuas yog ib hnub ib.

Nws tsis muaj contraindications thaum sib cuam tshuam nrog lwm yam tshuaj, uas tshwj xeeb yog nyiam. Nws tsis muaj kev cuam tshuam rau sab ntsuj plig thiab tsis ua rau ntus pw. Tsav tsheb nrog nws tsis txwv.

Kuv txaus siab rau txhua yam, txoj kev kho kom zoo uas tsis ua rau muaj kev phiv rau kuv.

Vipidia ntsiav tshuaj - cov lus qhia rau kev siv thiab tshuaj yeeb yaj kiab

Ntshav qab zib mellitus yog ib yam kab mob uas txaus ntshai heev thiab txaus ntshai. Cov neeg mob uas kuaj pom no yuav tsum tau soj ntsuam lawv cov ntshav qab zib tas mus li thiab tswj nws txoj kev noj tshuaj, txwv tsis pub lub txiaj ntsig ua rau neeg tuag tau.

Tias yog vim li cas nws thiaj li tseem ceeb kom paub txog tias cov tshuaj tsim los tiv thaiv cov tsos mob ntawm tus kab mob no ua haujlwm li cas. Ib tus ntawm lawv yog Vipidia.

Cov ntaub ntawv tshuaj dav dav

Cov cuab yeej no hais txog kev tsim kho tshiab hauv thaj tsam mob ntshav qab zib. Nws yog tsim rau cov neeg muaj kuaj mob ntshav qab zib hom 2. Vipidia tuaj yeem siv ob leeg tib leeg thiab ua ke nrog lwm cov tshuaj ntawm pawg no.

Koj yuav tsum nkag siab tias kev siv tshuaj tsis tswj tsis tu ncua tuaj yeem tsim kev phom sij rau tus neeg mob, yog li koj yuav tsum ua raws li kws kho mob pom zoo. Koj tuaj yeem siv tsis tau cov tshuaj yam tsis tau sau ntawv noj, tshwj xeeb tshaj yog thaum noj lwm yam tshuaj.

Lub npe lag luam rau cov tshuaj no yog Vipidia. Hauv theem thoob ntiaj teb, lub npe hu ua Alogliptin tau siv, uas los ntawm cov khoom tseem ceeb hauv nws cov muaj pes tsawg leeg.

Cov khoom yog sawv cev los ntawm oval zaj duab xis-coated ntsiav tshuaj. Lawv tuaj yeem yog daj lossis daj liab (nws nyob ntawm qhov tsuas tshuaj npaum li cas). Cov pob muaj 28 pcs. - 2 lub hau rau 14 ntsiav tshuaj.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Cov tshuaj Vipidia muaj nyob hauv Ireland. Daim ntawv ntawm nws tso tawm yog ntsiav tshuaj. Lawv yog ob hom, nyob ntawm cov ntsiab lus ntawm cov tshuaj nquag - 12,5 thiab 25 mg. Cov ntsiav tshuaj nrog tsawg dua cov tshuaj nquag muaj lub plhaub daj, nrog qhov loj dua - liab. Ntawm ib koog muaj cov ntawv sau uas tus ntim thiab cov khw tau qhia.

Lub hauv paus tseem ceeb ntawm cov tshuaj yog Alogliptin Benzoate (17 lossis 34 mg hauv txhua lub ntsiav tshuaj). Ntxiv rau nws, cov ntu pab tau muaj nyob hauv qhov muaj pes tsawg leeg, xws li:

microcrystalline cellulose,
mannitol
Kev Hyprolose
magnesium stereate,
croscarmellose sodium.

Cov khoom siv hauv qab no yog nyob hauv txheej zaj duab xis:

titanium dioxide
hypromellose 29104
macrogol 8000,
zas xim daj los yog xim liab (hlau oxide).

Pharmacological kev txiav txim

Cov cuab yeej no yog ua raws Alogliptin. Nov yog ib qho ntawm cov tshuaj tshiab uas tau siv los tswj cov qib qab zib. Nws zwm rau tus naj npawb ntawm hypoglycemic, muaj lub zog zoo.

Thaum siv nws, muaj kev nce ntxiv ntawm cov piam thaj hauv cov kua dej tso kua mis thaum txo cov glucagon ntau lawm yog tias cov piam thaj hauv ntshav nce ntxiv.

Nrog tus mob ntshav qab zib hom 2, nrog hyperglycemia, cov nta ntawm Vipidia pab txhawb kom muaj kev hloov pauv zoo li:

ua rau cov ntshav glycated hemoglobin (НbА1С),
txo cov ntshav qabzib ntau ntau.

Qhov no ua rau cov cuab yeej no muaj txiaj ntsig ntawm kev kho ntshav qab zib.

Kev taw qhia thiab contraindications

Cov tshuaj uas muaj qhov tshwm sim los ntawm muaj zog yuav tsum ua tib zoo siv. Cov lus qhia rau lawv yuav tsum tau ua raws txoj cai, txwv tsis pub muaj txiaj ntsig rau tus neeg mob lub cev yuav raug mob. Yog li, koj tuaj yeem siv Vipidia tsuas yog kev pom zoo ntawm cov kws tshaj lij nrog kev soj ntsuam nruj ntawm cov lus qhia.

Cov cuab yeej pom zoo rau siv nrog ntshav qab zib hom 2. Nws muab cov kev cai ntawm cov piam thaj hauv rooj plaub thaum siv tshuaj kho zaub mov tsis siv thiab qhov kev qoj ib ce tsim nyog tsis muaj. Ua tau zoo siv cov tshuaj rau monotherapy. Nws tseem raug tso cai siv nrog kev siv ua ke nrog lwm cov tshuaj uas pab txo qis dua cov piam thaj.

Ceev faj thaum siv cov tshuaj ntshav qab zib no tshwm sim los ntawm qhov muaj qhov tsis sib xws. Yog tias lawv tsis raug suav nrog, kev kho yuav tsis muaj txiaj ntsig thiab tuaj yeem ua rau muaj kev phom sij.

Vipidia tsis raug tso cai nyob rau hauv cov xwm txheej hauv qab no:

kev tsis qaug rau lub zog ntawm cov tshuaj,
ntshav qab zib hom 1
lub plawv dhia tsis zoo
daim siab mob
mob raum ntau
cev xeeb tub thiab lactation,
kev tsim kho ketoacidosis los ntawm ntshav qab zib,
tus neeg mob lub hnub nyoog txog 18 xyoo.

Cov kev ua txhaum no yog nruj contraindications rau siv.

Nws tseem muaj lub xeev hauv cov tshuaj uas tau sau tseg kom zoo:

pancreatitis
lub raum tsis ua hauj lwm ntawm mob hnyav hnyav.

Ib qho ntxiv, kev saib xyuas yuav tsum tau noj thaum sau ntawv rau Vipidia nrog rau lwm cov tshuaj los tswj cov ntshav qabzib.

Sab sij huam

Thaum kho nrog cov tshuaj no, qee zaum muaj kev phiv tshuaj nrog kev cuam tshuam ntawm cov tshuaj tshwm sim:

mob taub hau
ua pa tau kab mob
nasopharyngitis,
mob plab
khaus
daim tawv nqaij ua pob,
mob leeg txhaj leeg
urticaria
kev loj hlob ntawm daim siab ua haujlwm.

Yog tias muaj kev mob tshwm sim, sab laj nrog kws kho mob. Yog tias lawv qhov tshwm sim tsis ua teeb meem rau tus neeg mob txoj kev noj qab haus huv, thiab lawv qhov kev siv tsis tau nce ntxiv, kev kho mob nrog Vipidia tuaj yeem txuas ntxiv. Qhov mob hnyav ntawm tus neeg mob yuav tsum tau tshem tawm cov tshuaj tam sim ntawd.

Tsuas tshuaj thiab tswj hwm

Cov tshuaj no yog npaj rau lub luag haujlwm. Qhov ntau npaum li cas tau muab xam rau ntawm tus kheej, raws li qhov mob hnyav, lub hnub nyoog ntawm tus neeg mob, cov kab mob sib kis thiab lwm yam ntxwv.

Qhov nruab nrab, nws yuav tsum noj ib ntsiav tshuaj muaj 25 mg ntawm lub nquag ua tshuaj. Thaum siv Vipidia hauv ib qhov tshuaj 12,5 mg, qhov tshuaj txhua hnub yog 2 ntsiav tshuaj.

Nws raug nquahu kom noj cov tshuaj ib hnub ib zaug. Cov tshuaj yuav tsum ua kom qaug cawv tsis tas yuav zom. Nws raug nquahu kom haus lawv nrog dej npau. Kev txais tos yog pub ob qho tib si ua ntej thiab tom qab noj mov.

Tsis txhob siv ob zaug tshuaj ntawm cov tshuaj yog tias ib zaug tsis nco qab - qhov no tuaj yeem ua rau ploj mus. Koj yuav tsum tau noj lub niaj zaus ntawm cov tshuaj nyob rau hauv lub heev ze yav tom ntej.

Npaj cov haujlwm zoo sib xws

Thaum tsis muaj cov tshuaj uas yuav muaj cov muaj zog thiab ua rau tib yam. Tab sis muaj cov tshuaj uas zoo sib xws hauv nqe, tab sis tsim los ntawm lwm cov khoom xyaw nquag uas tuaj yeem ua analogues ntawm Vipidia.

Cov no suav nrog:

Januvia.Cov tshuaj no tau pom zoo kom txo cov ntshav qab zib. Tus nquag ua hauj lwm yog sitagliptin. Nws yog tshuaj nyob hauv tib kis zoo li Vipidia.
GalvusCov. Cov tshuaj yog nce raws Vildagliptin. Cov khoom no yog qhov sib piv ntawm Alogliptin thiab muaj tib lub zog.
JanumetCov. Qhov no yog kev sib txuam ua ke nrog hypoglycemic effect. Lub ntsiab ntawm cov tseem ceeb yog Metformin thiab Sitagliptin.

Cov kws muag tshuaj kuj tseem tuaj yeem muab lwm yam tshuaj los hloov Vipidia. Yog li, nws tsis tas yuav zais los ntawm kws kho mob cov kev hloov pauv hauv lub cev cuam tshuam nrog nws qhov kev nqus.

Tus neeg mob lub tswv yim

Los ntawm kev tshuaj xyuas ntawm cov neeg mob noj Vipidia, nws tuaj yeem xaus lus tias cov ntsiav tshuaj tau zoo txaus thiab pab tswj cov ntshav qab zib kom ib txwm, tab sis lawv yuav tsum ua raws li cov lus qhia nruj me ntsis, tom qab ntawd cov kev mob tshwm sim tsis tshua muaj thiab sai dhau.

Cov khoom siv vis dis aus hais txog qhov ua, mob thiab kho ntshav qab zib:

Tus nqi ntawm Vipidia tej zaum yuav sib txawv hauv cov chaw muag tshuaj hauv ntau lub nroog. Tus nqi ntawm cov tshuaj no hauv qhov ntau npaum ntawm 12.5 mg nws txawv ntawm 900 txog 1050 rubles. Kev yuav ib cov tshuaj uas muaj koob tshuaj 25 mg yuav raug nqi ntau dua - ntawm 1100 txog 1400 rubles.

Khaw cov tshuaj cia rau cov chaw tsis pub me nyuam siv cuag tau. Tshav ntuj thiab noo noo tsis tso cai rau ntawm nws. Kev cia khoom kub yuav tsum tsis tshaj 25 degrees. 3 xyoos tom qab tso tawm, hnub tas sij hawm ntawm cov tshuaj xaus, tom qab uas nws txoj kev coj ua txwv tsis pub.

Pom zoo Lwm Yam Lus Txog

Vipidia: cov tshuaj no zoo li cas thiab lawv yuav pab tau li cas kom ntshav qab zib

Vipidia yog ib qho ntawm ntau cov tshuaj rau kev kho qhov ncauj ntawm tus mob ntshav qab zib hom 2. Nws tuaj yeem siv ob qho tib si ntawm nws tus kheej, uas yog, rau kev kho mob hlwb, thiab hauv kev sib xyaw nrog lwm cov tshuaj.

Cov tshuaj nquag - alogliptin, belongs rau ib tiam tshiab, sawv cev rau pawg ntawm incretin mimetics. Lawv teb rau cov khoom noj kom tsawg los ntawm kev ua kom cov tshuaj insulin ntau lawm.

Vipidia ntsiav tshuaj rau cov ntshav qab zib muaj feem ntau muaj kev tshuaj xyuas zoo, uas yog vim qhov ua tau zoo thiab ua haujlwm ntawm cov tshuaj.

Lub cim tseem ceeb thiab contraindications

Cov tshuaj muaj zog ntawm Vipidia xaiv cuam tshuam rau dipeptidyl peptidase-4 (DPP-4). Cov lus qhia feem ntau ua haujlwm ntau zuj zus, uas yog tshwm ntawm qhov tshwm sim ntawm kev kho.

Txee lub neej ntawm cov khoom no yog peb xyoos, tom qab uas nws tsis pom zoo siv nws.

Koj yuav tsum khaws cov tshuaj rau hauv qhov chaw uas tsis muaj kev sib cuag nrog lub hnub ci, thiab qhov kub tsis ncav cuag 25 degrees.

Vipidia yog cov tshuaj ua kom txo qis ntshav qab zib. Nws yog siv hauv kev kho mob ntshav qab zib hom 2.

Nws raug nquahu kom pib noj nws thaum ua raws li cov lus qhia noj haus nrog rau kev tawm dag zog lub cev tsis muab cov yam xav ua.

Nws raug tso cai siv raws li kev kho mob monotherapy, txoj kev kho mob nyuaj nrog lwm cov tshuaj kho mob, nrog rau kev sib xyaw nrog cov tshuaj insulin.

Muaj ntau ntau tus contraindications rau noj cov tshuaj no.

Lub xub ntiag ntawm kev tsis haum tshuaj lossis lwm qhov kev ua kom lub cev tsis tshua haum rau cov tshuaj nquag lossis pabcuam ntawm Vipidia.
Yam 1 ntshav qab zib.
Tag nrho cov kev cuam tshuam ntawm cov metabolism hauv cov metabolism - ketosis, lub xeev hyperglycemic pheej, kev mob ntshav qab zib.
Congestive lub plawv tsis ua haujlwm.
Kev ua haujlwm hnyav ntawm lub siab, nrog nws ua haujlwm tsis ua haujlwm.
Mob raum nrog lub raum tsis ua haujlwm.
Lub sijhawm ntawm cev xeeb tub, lactation.
Tus neeg tsis tau muaj hnub nyoog 18 xyoo rov hauv kuj raug txwv.

Nrog kev ceev faj thiab nyob rau hauv kev saib xyuas kev noj qab haus huv, cov tshuaj tau raug sau yog tias tus neeg mob muaj mob voos los yog mob ntev, nrog rau kev ua haujlwm ntawm lub raum thiab mob siab. Thaum siv Vipidia ua ib feem ntawm txoj kev kho mob nyuaj nrog lwm cov tshuaj, lawv kev sib cuam tshuam yuav tsum ua tib zoo kawm.

Nyeem ntxiv Dab tsi koj yuav tsum paub txog kev kho mob ntshav qab zib hom 1 thiab type 2.

Muaj kev phiv ntau

Thaum noj cov tshuaj no, qee qhov kev mob tshwm sim yuav tshwm sim.

Lub paj hlwb teb nrog kev txhim kho mob taub hau.
Lub plab zom mov tuaj yeem cuam tshuam nrog cov tsos ntawm gastroesophageal reflux, mob hauv thaj av epigastric, thiab tseem ua rau exacerbation ntawm pancreatitis yog sau tseg.
Hauv qee kis, muaj kev ua txhaum ntawm txoj haujlwm li qub ntawm lub siab, lub zais zis.
O o oropharynx.
Ib qho kev mob tshwm sim tsis txaus ntseeg tshaj plaws tuaj yeem yog kev ua xua, uas pom los ntawm khaus, Quincke's edema, urticaria.

Phenomena ntawm anaphylaxis yog qhov tsis tshua muaj neeg pom, tab sis xws li kev muaj peev xwm ua tau.

Yog tias peb tham txog Vipidia nrog qhov muag ntawm kev tshuaj xyuas sab laug los ntawm cov neeg mob uas tau siv cov tshuaj no, peb tuaj yeem xaus tias nws muaj txiaj ntsig zoo tiv thaiv ntshav qab zib hom 2. Nws tso cai rau koj kom ua tiav kev tswj hwm tus kabmob, tswj lub sijhawm glycemic profile, txo glycosylated hemoglobin, qhia qhov ua tau ntawm txhua txoj kev kho.

Nyeem ntxiv. Nws puas muaj qhov tsis zoo ntawm kev tshaib plab nrog ntshav qab zib hom 2

Qhov no yog qhov cuab yeej tshwj xeeb uas tsis muaj neeg analogues nyob hauv nws cov muaj pes tsawg leeg txij li niaj hnub no. Ntawd yog, nyob hauv lub ntiaj teb tsis muaj lwm yam tshuaj uas nws lub ntsiab nquag ua yog alogliptin.

Txawm li cas los xij, muaj ntau lwm yam tshuaj cuam tshuam nrog rau ncetomimetics. Lawv raug suav tias yog analogues ntawm Vipidia, nrog rau nws cov neeg sib tw hauv cov khw muag tshuaj. Qhov nrov tshaj plaws thiab pom tshwm sim hauv cov teb chaws sib txawv.

Nws cov tshuaj tseem ceeb yog sitagliptin. Cov tshuaj raug faib tawm hauv cov ntsiav tshuaj, noj tshuaj 25, 50, 100 milligrams. Nws muaj qhov tseeb tib yam qhia vipidia, thaum nws tseem siv ua ib feem ntawm kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg sawv cev.

Qhov no yog kev sib koom ua ke ntawm Januvia, muaj pes tsawg leeg uas tseem muaj Metformin. Qhov ntau npaum li cas ntawm sitagliptin yog 50 milligrams, metformin tuaj yeem nyob hauv peb ntau koob tshuaj - 500, 850 lossis 1000 milligrams.

Nws kuj tseem yog cov tshuaj sib xyaw ua ke raws li vildagliptin (inherently zoo ib yam li alogliptin) nrog metformin. Dosages yog tib yam li cov ntawm Yanumet.

Monopreparation. Nws yog tsim ntawm lub hauv paus ntawm cov nquag khoom saxagliptin. Los ntawm nws cov xwm, nws tau suav hais tias yog kev rhuav tshem ntawm incretins, uas yog, nws muaj cov txheej txheem sib txawv me ntsis ntawm Vipidia, tab sis nws yog rau tib pawg tshuaj. Cov koob tshuaj yog 2.5 thiab 5 milligrams.

Combogliz ntev

Qhov no yog cov tshuaj ua ke uas suav nrog saxagliptin nrog metformin. Nws muaj lub caij nyoog ntev vim qhov qeeb tso tawm ntawm cov khoom siv nquag.

Niaj hnub no, Vipidia yog qhov tshuaj tshiab tshaj plaws los ntawm pab pawg ntawm incretin mimetics. Nws siv qhia tau zoo heev, thiab tus nqi rau nws yog qhov tsim nyog, uas tau coj mus rau qhov tseeb tias ntau tus kws kho mob endocrinologist tau noj cov tshuaj no mus rau kev pabcuam.

Kev ntsuas rau siv

Vipidia yog qhov tshuaj hypoglycemic hauv qhov ncauj. Nws yog tsim nyob rau hauv daim ntawv ntawm oval ntsiav tshuaj ntawm daj los yog xim liab nrog lub tuam txhab luam tawm thiab cov lej txhim kho qhov kev xav ntawm cov khoom nquag.

Cov tshuaj yog tsim hauv cov qauv hauv cov ntsiav tshuaj, tsim rau 2 qhov ntau:

ntsiav tshuaj muaj alogliptin benzoate - 12,5 mg, pleev xim daj,
ntsiav tshuaj nrog cov tshuaj nquag nyob hauv qhov nyiaj ntawm 25 mg - hauv xim liab.

Vipidia yog siv rau hom II mob ntshav qab zib mellitus raws li cov tshuaj ywj siab los yog hauv kev sib xyaw nrog lwm cov tshuaj tsom rau txo cov ntshav qab zib.

Cov tshuaj nquag siv ntawm cov tshuaj yog ib qho cuab yeej tshiab uas cuam tshuam nrog incretinomimetics. Lawv lub hom phiaj yog txhawm rau txhawb lub cev kom tso cov kua dej qab zib tawm tom qab noj mov. Pawg tshuaj yeeb tshuaj no tseem muaj cov tshuaj glucagon zoo li polypeptide thiab glucose-nyob rau insulinotropic polypeptide.

Alogliptin yog qhov txawv los ntawm nws cov kev xaiv nrog kev hwm ntawm enzyme dipeptidyl peptidase-4. Lub tom kawg tuaj yeem rhuav tshem cov tshuaj hormones los ntawm pab pawg ntawm incretins nrog qhov nrawm. Lawv tuaj yeem tsim ua ke hauv plab hnyuv thiab, thaum noj mov, pab txhawb kev tsim cov tshuaj insulin hauv cov txiav ntshav.

Ib qho zoo li peptide zoo li peptide txo qis glucagon ntau lawm, yog li txo qis cov piam thaj hauv daim siab. Nrog rau kev ua kom nce ntxiv, alogliptin ua rau muaj zog ntxiv ntawm insulin ntau lawm.

Nyob rau tib lub sijhawm, qhov concentration ntawm glucagon txo qis tawm tsam ntawm keeb kwm ntawm ib qho nce ntxiv hauv qib ntawm cov piam thaj hauv cov ntshav. Cov txheej txheem no ua rau txo qis glycosylated hemoglobin hauv cov neeg muaj ntshav qab zib tsis muaj tshuaj insulin.

Ib qho ntxiv, cov ntshav ntawm cov ntshav qab zib yog ib txwm ua rau ob qho tib si ntawm lub plab thiab tom qab ua kom ntshav khov.

Vipidia yog ib qho kev kho mob siv los txhim kho cov neeg mob ntshav qab zib hom II. Nws lub luag haujlwm tseem ceeb yog ua kom muaj kev ua tau zoo ntawm qab zib.

Cov tshuaj yog siv thaum noj ntawm qhov ncauj. Cov tshuaj zoo rau kev kho mob yog 25 mg. Nws tsuas yog noj 1 zaug ib hnub twg. Cov ntsiav tshuaj tau nqos nws tag nrho thiab ntxuav nrog dej kom huv.

Yog tias qhov no tau tshwm sim, tom qab ntawd siv tshuaj rau ob npaug rau hnub no thiab nag hmo tsis tuaj yeem ua. Nkag mus ntxiv yuav tsum tau nqa tawm hauv hom kev pom zoo.

Yog tias Vipidia yog siv ua ke nrog metformin lossis thiazolidinedione, ces nws tseem tuaj yeem tsis hloov pauv qhov noj ntau npaum li cas.

Kev hloov pauv tsuas yog tsim yog tias cov tshuaj siv nrog sulfonylurea derivatives los yog nrog cov tshuaj insulin thiaj li yuav txo qhov ua rau muaj ntshav qab zib tsawg. Kev saib xyuas tshwj xeeb yog xav tau thaum kho nrog metformin thiab thiazolidinedione. Yog tias cov tsos mob hypoglycemia tshwm sim, qhov tsis haum ntawm metformin lossis thiazolidinedione yuav tsum raug txo kom tsawg.

Vipidia cov lus piv txwv

Cov tshuaj Analogues ntawm cov tshuaj yog cov tshuaj uas muaj cov tshuaj sib txawv, tab sis siv los kho cov mob tib yam nrog tib tus mob.

Vipidia analogues muaj alogliptin tseem tsis tau muaj. Txawm li cas los xij, hauv kev xyaum ua kom zoo li qub, kho kom zoo cov neeg ua hauj lwm los ntawm cov pab pawg ntawm incretin mimetics nrog cov sib txawv sib txawv yog siv dav. Cov no suav nrog cov hauv qab no:

Xws li ntau ntawm cov duab tsis zoo hais txog qhov tseeb thiab qhov tseem ceeb ntawm cov tshuaj ntawm kev ua no. Kev tshuaj xyuas txog Vipidia thiab cov tshuaj uas zoo sib xws yog feem ntau zoo.

Qhov teeb meem nkaus xwb yog tias txhua yam tshuaj uas tswj cov muaj suab thaj hauv ntshav qab zib muaj ntau yam kev sib txuam thiab cov kev mob tshwm sim.

Tsis tas li, lawv daim ntawv thov yuav tsum muaj kev paub txog lub xeev ntawm lub cev, muaj lwm yam kabmob, thiab tseem yuav tsum tau saib xyuas tas li tsis tsuas yog cov ntshav qab zib, tab sis kuj tseem muaj lwm qhov ntsuas ntawm lub cev.

Kev siv tshuaj hypoglycemic, ib qho muaj zog thiab xaiv cov muaj zog ntawm dipeptidyl peptidase-4 (DPP-4).

Nws cov kev xaiv rau DPP-4 yog ntau dua 10,000 zaug ntau dua nws cov nyhuv rau lwm cov enzymes muaj feem xyuam, suav nrog DPP-8 thiab DPP-9.

DPP-4 yog qhov tseem ceeb enzyme koom nrog kev rhuav tshem cov tshuaj hormones sai ntawm tsev neeg ntau ntxiv: glucagon-zoo li peptide-1 (GLP-1) thiab glucose-dependant insulinotropic polypeptide (HIP).

Cov tshuaj hormones ntawm tsev neeg incretin yog zais cia hauv txoj hnyuv, lawv qhov kev nce siab hauv cov lus teb ntxiv rau kev noj zaub mov. GLP-1 thiab HIP nce insulin synthesis thiab nws txoj kev zais cia los ntawm pancreatic β-hlwb.GLP-1 kuj tseem txwv tsis pub cov kab mob glucagon ua kom lub ntsej muag thiab txo cov ntshav qabzib.

Yog li no, nce lub concentration ntawm incretins, alogliptin tsub kom cov piam thaj tso cov kua dej ntawm cov tshuaj insulin thiab txo qis kev tso zis ntawm glucagon nrog kev nce siab ntawm cov piam thaj hauv cov ntshav.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus nrog hyperglycemia, cov kev hloov pauv hauv kev zais ntawm insulin thiab glucagon ua rau txo qis ntawm glycosylated hemoglobin НbА1С thiab qhov txo qis hauv cov concentration ntawm cov piam thaj hauv ntshav plasma ntawm ob qho kev yoo thiab postprandial qabzib.

Vipidia - cov lus qhia ntawm kev rau siv, analogues

1 ntsiav tshuaj 12,5 mg muaj

Cov tshuaj nquag: alogliptin benzoate - 17 mg (hais txog alogliptin - 12,5 mg).

Cov tshuaj nquag: alogliptin benzoate - 34 mg (hais txog alogliptin -25 mg).

Cov muaj tswv yim:
Cov tub ntxhais: mannitol 79.7 mg, microcrystalline cellulose 22.5 mg, hyprolose 4.5 mg, croscarmellose sodium 7.5 mg, magnesium stearate 1.8 mg.

Zaj duab xis txheej: hypromellose 2910 5.34 mg, titanium dioxide 0.6 mg, hlau zas hlau oxide liab 0.06 mg, macrogol-8000 tus nqi nyiaj, kua mem kua xim F1 tus nqi nyiaj 1.

Kev piav qhia
Dosage 12.5 mg Oval biconvex ntsiav tshuaj, coated nrog cov xim ua cov xim daj, nrog cov ntawv sau "TAK" thiab "ALG-12.5" ntawm ib sab.

Tus kab mob hypoglycemic yog dipeptidyl peptidase-4 inhibitor (DPP-4).

Cov Tshuaj Hauv Tshuaj

Alogliptin yog qhov muaj zog thiab xaiv qhov muaj zog ntawm DPP-4.

Nws cov kev xaiv rau DPP-4 yog ntau dua 10,000 zaug ntau dua nws cov nyhuv rau lwm cov enzymes muaj feem xyuam, suav nrog DPP-8 thiab DPP-9.

Cov tshuaj hormones ntawm tsev neeg incretin yog zais cia hauv txoj hnyuv, lawv qhov kev nce siab hauv cov lus teb ntxiv rau kev noj zaub mov. GLP-1 thiab HIP nce insulin synthesis thiab nws txoj kev zais cia los ntawm pancreatic beta hlwb. GLP-1 kuj tseem txwv tsis pub cov kab mob glucagon ua kom lub ntsej muag thiab txo cov ntshav qabzib.

Yog li no, nce lub concentration ntawm incretins, alogliptin tsub kom cov piam thaj tso cov kua dej ntawm cov tshuaj insulin thiab txo qis kev tso zis ntawm glucagon nrog kev nce siab ntawm cov piam thaj hauv cov ntshav.

Hauv cov neeg mob uas muaj hom 2 mob ntshav qab zib mellitus nrog hyperglycemia, cov kev hloov pauv hauv kev zais ntawm insulin thiab glucagon ua rau txo qis ntawm cov ntshav glycosylated hemoglobin HbA1c thiab txo qis hauv cov concentration ntawm cov piam thaj hauv cov ntshav ntshav ntawm ob qho kev yoo thiab postprandial qabzib.

Cov Tshuaj Pharmacokinetics Cov tshuaj pharmacokinetics ntawm alogliptin zoo sib xws hauv cov neeg muaj kev noj qab haus huv thiab hauv cov neeg mob uas muaj ntshav qab zib hom 2.

Qhov tseeb ntawm bioavailability ntawm alogliptin yog kwv yees li 100%. Concomitant siv nrog cov zaub mov muaj roj ntau tsis muaj kev cuam tshuam thaj chaw hauv qab qhov concentration-time (AUC) nkhaus ntawm alogliptin, yog li nws tuaj yeem nqa tsis hais cov pluas noj. Hauv cov neeg muaj kev noj qab haus huv, tom qab ib qho kev tswj hwm ntawm qhov ncauj txog li 800 mg ntawm alogliptin, kev nqus tshuaj sai yog pom nrog kev ncav cuag qhov nruab nrab siab tshaj plaws (qhov nruab nrab TCmax.) Hauv thaj tsam li 1 mus rau 2 teev txij li lub sijhawm saib xyuas. Cov neeg tuaj yeem noj qab nyob zoo tsis tuaj yeem mob rau cov neeg mob ntshav qab zib hom 2 mob ntshav qab zib ua rau pom muaj kev sib xyaw ua ke ntawm alogliptin tom qab rov qab siv dua. AUC ntawm alogliptin nce nce ntxiv nrog cov koob tshuaj ib zaug hauv kev kho mob ntau li ntawm 6.25 mg txog 100 mg. Qhov hloov pauv coefficient ntawm AUC ntawm alogliptin ntawm cov neeg mob yog me (17%). AUC (O-inf) ntawm alogliptin tom qab ib koob nkaus xwb zoo ib yam li AUC (0-24) tom qab noj tib lub tshuaj ib zaug ib hnub rau 6 hnub. Qhov no qhia tau tias tsis muaj ib lub sijhawm nyob ntawm kinetics ntawm alogliptin tom qab rov ua dua.

Tom qab kev tso tshuaj ib leeg ntawm alogliptin ntawm koob tshuaj 12,5 mg rau cov neeg ua haujlwm noj qab haus huv, cov ntim hauv qhov davhlau ya nyob twg yog 417 L, uas qhia tau tias alogliptin zoo xa tawm hauv cov ntaub so ntswg. Kev sib txuas lus nrog cov protein ntshav yog kwv yees li 20-30%.

Alogliptin tsis raug rau cov metabolism hauv lub siab, txij li 60 mus rau 70% ntawm alogliptin raug cais tawm tsis hloov pauv los ntawm lub raum.

Tom qab kev tswj hwm ntawm 14C-daim ntawv lo alogliptin sab hauv, ob lub ntsiab metabolites tau txiav txim siab: N-demethylated alogliptin, M-I (50 txog 30 rau 1/100, 1/1000, 1/10 000,