Sofamet > Kev khomob thiab kev tiv thaiv

Cov ntsiav tshuaj dawb, oblong, biconvex, nrog ib qho kev ceeb toom ntawm ob sab, ntawm pob txha ntawm cov xim dawb.

1 tab
metformin hydrochloride	850 mg

Tshwjxeeb: povidone K25, microcrystalline cellulose, sorbitol, magnesium stearate.

Cov khoom sib xyaw ntawm cov zaj duab xis plhaub: Opadry II dawb (hypromellose 2910, titanium dioxide, lactose monohydrate, macrogol 3000, triacetin)

10 Pcs - hlwv (3) - pob khoom los ntawm cardboard.

Pharmacological kev txiav txim

Qhov ncauj hypoglycemic tus neeg sawv cev los ntawm pab pawg ntawm biguanides (dimethylbiguanide). Tus txheej txheem ntawm kev ua ntawm metformin yog txuam nrog nws lub peev xwm los txwv gluconeogenesis, nrog rau kev tsim cov roj dawb dawb thiab oxidation ntawm cov rog. Tsub qhov rhiab heev ntawm peripheral receptors rau insulin thiab kev siv cov kua nplaum los ntawm lub hlwb. Metformin tsis cuam tshuam rau cov tshuaj insulin hauv cov ntshav, tab sis hloov nws cov chaw muag tshuaj los ntawm kev txo qis ntawm qhov khi ntawm cov kua dej mus rau dawb thiab nce qhov feem ntawm cov insulin rau proinsulin.

Metformin stimulates glycogen synthesis los ntawm kev ua ntawm glycogen synthetase. Tsub kom muaj peev xwm thauj tau txhua yam ntawm cov khoom thauj ua kua roj ntau dua. Ncua kev nqus cov hnyuv ntawm lub ntsej muag.

Txo cov qib triglycerides, LDL, VLDL. Metformin kho txhim kho cov khoom fibrinolytic ntawm cov ntshav los ntawm kev tiv thaiv cov nqaij mos-plasminogen activator inhibitor.

Thaum noj cov tshuaj metformin, tus neeg mob lub cev hnyav dua li qub tseem ruaj khov lossis txo qis.

Cov Tshuaj Pharmacokinetics

Tom qab kev tswj hwm ntawm qhov ncauj, metformin maj mam thiab ua tsis tiav cov pa hauv cov hnyuv. C max hauv ntshav tau mus txog tom qab li 2.5 teev. Nrog ib koob tshuaj 500 mg, qhov tsis txaus ntseeg tiag tiag txog 50-60%. Nrog kev noj ib txhij, kev nqus ntawm metformin yog txo thiab qeeb.

Metformin tau faib sai sai rau hauv cov ntaub so ntswg hauv lub cev. Nws xyaum tsis khi rau cov plasma protein. Nws accumulates nyob rau hauv salivary qog, mob siab thiab ob lub raum.

Nws yog tawm los ntawm lub raum tsis hloov pauv. T 1/2 los ntawm cov ntshav ntshav yog 2-6 teev.

Yog tias ua kom lub raum khiav tsis zoo, ua kom ntau ntawm metformin yog ua tau.

Tshuaj los qhia

Hom 2 mob ntshav qab zib mellitus (non-insulin-dependant) nrog kev noj zaub mov noj thiab kev tawm dag zog tsis muaj zog, hauv cov neeg mob rog rog: hauv cov neeg laus - raws li kev kho mob monotherapy lossis hauv kev sib xyaw nrog lwm tus neeg lub qhov ncauj hypoglycemic lossis nrog insulin, hauv cov menyuam hnub nyoog 10 xyoo thiab laus dua - raws li kev kho mob monotherapy lossis txuam nrog cov tshuaj insulin.

ICD-10 cov lis dej num

ICD-10 code	Kev taw qhia
E11	Mob ntshav qab zib Hom 2

Kev noj tshuaj ntxiv

Nws yog noj ntawm qhov ncauj, thaum lossis tom qab noj mov.

Cov koob tshuaj thiab qhov ntau zaus ntawm cov thawj coj yog nyob ntawm daim ntawv ntau npaum siv.

Nrog kev kho mob monotherapy, thawj koob tshuaj rau cov neeg laus yog 500 mg, nyob ntawm daim ntawv ntau npaum li cas tau siv, qhov ntau zaus ntawm kev tswj hwm yog 1-3 zaug / hnub. Nws tuaj yeem siv 850 mg 1-2 zaug / hnub. Yog tias tsim nyog, cov koob tshuaj tau maj mam nce nrog qhov luv ntawm 1 lub lim tiam. txog li 2-3 g / hnub.

Nrog tshuaj monotherapy rau cov menyuam yaus hnub nyoog 10 xyoo thiab laus dua, thawj koob tshuaj yog 500 mg lossis 850 1 zaug / hnub lossis 500 mg 2 zaug / hnub. Yog tias tsim nyog, nrog kev ncua sij hawm tsawg kawg 1 lub lis piam, qhov koob tshuaj yuav raug nce ntxiv mus txog qhov ntau ntawm 2 g / hnub hauv 2-3 koob.

Tom qab 10-15 hnub, koob tshuaj yuav tsum tau kho raws cov txiaj ntsig kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Hauv kev kho ua ke nrog kev siv tshuaj insulin, thawj koob tshuaj metformin yog 500-850 mg 2-3 zaug / hnub. Cov koob tshuaj insulin raug xaiv raws li cov txiaj ntsig kev txiav txim siab ntawm cov piam thaj hauv cov ntshav.

Sab sij huam

Los ntawm lub plab zom mov: muaj peev xwm (feem ntau thaum pib kho) xeev siab, ntuav, raws plab, pom, tsis xis nyob rau hauv plab, hauv cov kis mob cais tawm - qhov ua txhaum ntawm lub siab ua haujlwm, mob siab (ploj lawm tom qab kho yog nres).

Los ntawm ib sab ntawm cov metabolism: tsis tshua muaj - lactic acidosis (tsum tsis ua kev kho mob).

Los ntawm cov kab mob hemopoietic: tsis tshua muaj tshwm sim - kev ua txhaum ntawm kev nqus ntawm cov vitamin B 12.

Daim ntawv qhia txoj kev tsis haum ntawm cov menyuam yaus hnub nyoog 10 xyoo thiab laus dua yog qhov zoo tib yam rau cov neeg laus.

Cov Yuav Tsum Muaj

Kev kub siab tsis txaus, hyperglycemic coma, ketoacidosis, mob raum tsis ua hauj lwm, kab mob siab, lub plawv tsis ua haujlwm, mob myocardial infarction, ua pa tsis ua haujlwm, lub cev qhuav dej, haus dej cawv, hypocaloric noj (tsawg dua 1000 kcal / hnub), lactic acidosis (suav nrog keeb kwm), cev xeeb tub, lactation lub sijhawm. Cov tshuaj tsis tau siv 2 hnub ua ntej kev phais mob, radioisotope, kev tshawb nrhiav xoo hluav taws xob nrog kev qhia ntawm iodine-muaj cov tshuaj tsis sib xws thiab tsis pub dhau 2 hnub tom qab lawv tau ua.

Yuav siv li cas: noj ntau thiab hom tshuaj kho

Sab hauv, lub sijhawm lossis tom qab noj mov tag, rau cov neeg mob tsis tau txais insulin, 1 g (2 ntsiav tshuaj) 2 zaug hauv ib hnub rau thawj 3 hnub lossis 500 mg 3 zaug hauv ib hnub, tom qab ntawd txij li 4 rau 14 hnub - 1 g 3 zaug hauv ib hnub, tom qab 15 hnub kev noj tshuaj tuaj yeem txo qis rau hauv tus account cov ntsiab lus ntawm cov piam thaj hauv cov ntshav thiab zis. Kev tu cov koob tshuaj txhua hnub - 1-2 g.

Cov ntsiav tshuaj rov qab (850 mg) tau noj 1 thaum sawv ntxov thiab yav tsaus ntuj. Qhov siab tshaj plaws niaj hnub noj yog 3 g.

Nrog rau kev siv tshuaj insulin ib txhij ntawm ib koob tsawg dua 40 units / hnub, kev noj tshuaj ntawm cov tshuaj metformin yog qhov qub, thaum lub koob tshuaj insulin tuaj yeem maj mam txo qis (los ntawm 4-8 units / hnub txhua lwm hnub). Thaum lub koob tshuaj insulin ntau dua 40 units / hnub, kev siv tshuaj metformin thiab txo qis ntawm cov tshuaj insulin yuav tsum muaj kev saib xyuas zoo thiab nqa tawm hauv tsev kho mob.

Analogues thiab tus nqi ntawm cov tshuaj Sofamet

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

txheej ntsiav tshuaj

txhawb nqa cov ntsiav tshuaj

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

zaj duab xis-txheej pab raws li tso ntsiav tshuaj

txhawb nqa cov ntsiav tshuaj

zaj duab xis-ntsiav tshuaj ntsiav tshuaj

Tag nrho cov npav: 73 tus kws kho mob.

Cov ntsiab lus ntawm cov neeg teb los ntawm kev tshwj xeeb:

Siv thaum cev xeeb tub

Thaum cev xeeb tub, nws muaj peev xwm yog tias qhov xav tau ntawm kev kho mob ntau dhau qhov kev pheej hmoo rau tus me nyuam hauv plab (kev tshawb fawb txaus thiab nruj me ntsis ntawm kev siv thaum cev xeeb tub tsis tau ua).

FDA qeb ntawm kev nqis tes ua rau tus menyuam yog B.

Thaum lub sijhawm kho yuav tsum tsis pub niam mis rau menyuam noj.

Sab sij huam

Los ntawm lub plab zom mov: xeev siab, ntuav, "nws yog xim hlau" saj hauv lub qhov ncauj, tsis qab los, ua tsis taus pa, tsis meej pem, mob plab.

Los ntawm ib sab ntawm cov metabolism: hauv qee kis - lactic acidosis (tsis muaj zog, myalgia, ua pa tsis meej, qaug zog, mob plab, hypothermia, txo cov ntshav siab, reflex bradyarrhythmia), nrog kev kho mob ntev - hypovitaminosis B12 (malabsorption).

Los ntawm cov kabmob hemopoietic: qee kis - megaloblastic anemia.

Kev ua xua rau: xoo pob khaus.

Yog tias muaj kev phiv, qhov tshuaj yuav tsum raug txo lossis txiav ib ntus.

Cov lus qhia tshwj xeeb

Thaum kho, kev saib xyuas lub raum kev ua haujlwm yog qhov tsim nyog; kev txiav txim siab ntawm cov ntshav lactate yuav tsum tau nqa tawm tsawg kawg 2 zaug hauv ib xyoos, nrog rau qhov pom ntawm myalgia. Nrog kev txhim kho ntawm cov kab mob lactic acidosis, kev txiav tawm ntawm kev kho mob yog yuav tsum tau ua.

Teem sij hawm yog tias muaj kev phom sij ntawm lub cev qhuav dej tsis tau pom zoo.

Kev phais mob thiab kev raug mob loj, kev kub nyhiab, kab mob kis nrog febrile syndrome yuav tsum muaj kev tshem tawm cov tshuaj glypoglycemic hauv qhov ncauj thiab kev tswj hwm cov tshuaj insulin.

Nrog kev kho ua ke nrog sulfonylurea derivatives, ua tib zoo saib xyuas ntshav qabzib concentration yog qhov tsim nyog.

Kev siv tshuaj tiv thaiv kab mob nrog kev pom zoo nyob hauv tsev kho mob.

Zoo ib yam tshuaj:

Tsheb Hliav Liab
Ascorutin (Ascorutin) Cov ntsiav tshuaj ntawm qhov ncauj
Kua mis nyeem qaub (yogurt) Tshuaj ntsiav
Ergoferon () lozenges
Magne B6 (Magne B6) cov ntsiav tshuaj hauv qhov ncauj
Omez Tshuaj Ntsiav
Papaverine (Papaverine) Cov ntsiav tshuaj ntawm lub qhov ncauj

** Qhia Txog Kev Siv Tshuaj Kho Mob yog rau cov lus qhia xwb. Xav paub ntau ntxiv, thov hu rau cov khw muag khoom ntim ntawv. Tsis txhob noj tshuaj rau yus tus kheej, ua ntej koj pib siv Sofamet, koj yuav tsum sab laj nrog kws kho mob. EUROLAB tsis yog lub luag haujlwm rau lub txim vim tshwm sim los ntawm kev siv cov ntaub ntawv tshaj tawm ntawm lub portal. Txhua yam ntaub ntawv ntawm lub vev xaib tsis hloov cov kws kho mob cov lus qhia thiab tsis tuaj yeem ua lub luag haujlwm ntawm lub luag haujlwm zoo ntawm cov tshuaj.

Xav paub txog Sofamet? Koj puas xav paub cov ncauj lus ntxaws ntxaws lossis koj puas xav ntsib kws kho mob? Los yog koj puas xav tau kev kuaj xyuas? Koj ua tau teem sijhawm nrog tus kws kho mob - chaw kho mob Euro lab ib txwm nyob ntawm koj qhov kev pabcuam! Cov kws kho mob zoo tshaj plaws yuav tshuaj xyuas koj, tawm tswv yim, muab kev pabcuam tsim nyog thiab ua kev kuaj mob. Koj tuaj yeem ua tau hu kws kho mob tom tsevCov. Chaw Kho Mob Euro lab qhib rau koj ib ncig ntawm lub moos.

** Mloog! Cov lus qhia hauv phau ntawv qhia tshuaj no yog npaj rau cov kws kho mob thiab tsis yog lub hauv paus rau kev siv tus kheej. Cov lus piav qhia ntawm Sofamet tsuas yog rau cov ntaub ntawv nkaus xwb thiab tsis yog tsim los rau kev kho mob yam tsis muaj kev koom tes ntawm kws kho mob. Cov neeg mob xav tau tswv yim tshwj xeeb!

Yog tias koj xav paub txog lwm yam tshuaj thiab cov tshuaj, lawv cov lus piav qhia thiab cov lus qhia rau kev siv, cov ntaub ntawv hais txog kev tsim tawm thiab daim ntawv tso tawm, qhia txog kev siv thiab kev phiv, txoj kev siv, nqi thiab tshuaj xyuas cov tshuaj, lossis koj puas muaj ib yam lwm cov lus nug thiab cov lus qhia - sau ntawv rau peb, peb yuav sim pab koj.

Kev sib txuam

Tsis sib haum nrog ethanol (lactate acidosis).

Siv nrog ceev faj nyob rau hauv ua ke nrog indirect anticoagulants thiab cimetidine.

Cov khoom siv ntawm sulfonylureas, insulin, acarbose, MAO inhibitors, oxytetracycline, ACE inhibitors, clofibrate, cyclophosphamide thiab salicylates txhim kho cov nyhuv.

Nrog rau kev siv ua ke nrog GCS, tshuaj tiv thaiv kev tiv thaiv qog rau kev tswj hwm qhov ncauj, epinephrine, glucagon, cov thyroid hormones, phenothiazine derivatives, thiazide diuretics, nicotinic acid derivatives, txo qis hauv cov nyhuv hypoglycemic ntawm metformin yog ua tau.

Nifedipine nce ntxiv kev nqus, Cmax, maj mam txo qis kev nthuav tawm.

Cov tshuaj Cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren thiab vancomycin) zais cia rau hauv cov tubules sib tw rau cov tshuab thauj tubular thiab tuaj yeem nce Cmax los ntawm 60% nrog kev kho mob ntev.

Kev ntsuas rau siv

Lub hom phiaj ntawm cov tshuaj yuav tsim nyog yog tias tus neeg mob muaj ntshav qab zib hom 2 (tsis yog tshuaj insulin-tiv thaiv). Qhov no yog qhov cuam tshuam tshwj xeeb tshaj yog tias, ua ntej yuav sau cov tshuaj, kev ib txwm noj ntawm kev noj haus thiab kev qhia ntawm kev ua kom lub cev tsis coj cov txiaj ntsig tsim nyog. Nws yog tshuaj, suav nrog cov neeg mob rog rog.

Lub hom phiaj ntawm cov tshuaj yuav tsim nyog yog tias tus neeg mob muaj ntshav qab zib hom 2.

Nrog ntshav qab zib

Kev txais tos yuav tsum tshwm sim thaum lossis tom qab noj mov. Thawj koob tshuaj rau cov neeg laus yog 500 mg 1-3 zaug ib hnub. Nws raug tso cai kom noj 850 mg 1-2 zaug ib hnub.

Tom qab 10-15 hnub ntawm kev muab tshuaj, qhov tshuaj yuav tuaj yeem kho los ntawm kws kho mob raws li cov ntshav qabzib muaj nuj nqis.

Hauv qee kis, tus kws kho mob txiav txim siab muab tshuaj kho sib xyaw nrog kev siv tshuaj insulin.

Siv thaum cev xeeb tub thiab lactation

Txij li thaum cov tshuaj yeeb dej caw muaj peev xwm hla dhau qhov kev tiv thaiv placental, nws txoj kev siv thaum lub caij cev xeeb tub yog ua tau tsuas yog qhov chaw kawg. Tus nquag nquag tuaj yeem nkag mus rau niam lub mis. Qhov no txhais tau hais tias thaum lub sijhawm lactation, cov tshuaj zoo dua tsis mus ua tshuaj.

Txij li thaum cov tshuaj yeeb dej caw muaj peev xwm hla dhau qhov kev tiv thaiv placental, nws txoj kev siv thaum lub caij cev xeeb tub yog ua tau tsuas yog qhov chaw kawg.

Noj ntau dhau ntawm Sofamet

Nrog kev haus tshuaj ntau dhau rau hauv lub cev, qhov kev txhim kho ntawm cov kab mob lactic acidosis nrog rau kev mob tshwm sim yog tau. Nws yog ib qho tsim nyog kom tshem tawm cov tshuaj ntawm lub cev siv hemodialysis.

Cov kab mob siab tseem ceeb yog qhov laj thawj ntawm kev ua tsis tau ntawm kev sau ntawv.

Cawv tau zoo

Kev sib xyaw ua ke ntawm cov tshuaj nrog dej cawv ua rau muaj kev pheej hmoo ntawm lactic acidosis.

Koj tuaj yeem hloov cov tshuaj ntawm cov tshuaj xws li Glucofage, Metospanin, Siafor.

Kev txheeb xyuas ntawm Sofamet

A.D. Shelestova, endocrinologist, Lipetsk: "Cov tshuaj pom tias muaj txiaj ntsig zoo hauv kev kho mob ntshav qab zib hom 2. Qhov no yog vim qhov tseeb ntawm cov txheej txheem ntawm kev ua yog txhawm rau txo cov piam thaj hauv cov ntshav. Yog li, cov txiaj ntsig tuaj yeem ua tiav hauv 2 lub lis piam ntawm kev kho mob, uas haum rau cov neeg mob. Nws yog ib qho tseem ceeb uas yuav tau txiav txim siab tias tom qab kev kho mob, koj yuav tsum tau ua lub neej noj qab haus huv thiab tswj kev ua kom lub cev muaj zog. "

S.R. Reshetova, endocrinologist, Orsk: "Tus neeg sawv cev ntawm tus kws kho mob tso cai rau kev ua tiav zoo rau kev kho mob ntawm cov ntshav qab zib theem 2. Lub sijhawm kho, nws yog ib qho tseem ceeb los saib xyuas qhov mob ntawm tus neeg mob, vim tias feem ntau qhov kev kho kom haum yuav tsum tau ua tom qab ib lub lim tiam ntawm kev kho mob. "Yog tias qhov no tshwm sim, tus neeg mob yuav tuaj yeem pab nrog hemodialysis."

Elvira, 34 xyoo, Lipetsk: "Nws tau pom tias kuv yuav tsum kho ntshav qab zib. Tus kab mob tsis zoo, nws ua rau ntau qhov tsis xis nyob. Cov kev kho mob nrog cov tshuaj no. Kuv tsis tau pom tias muaj cov kev mob tshwm sim, tab sis tsis txhim kho ntev tsis ntev tom ntej. Tus nqi ntawm cov tshuaj Kuv tuaj yeem coj nws tus yam ntxwv zoo tshaj plaws. Yog li ntawd, kuv qhia nws rau cov neeg mob ntshav qab zib. Cov tshuaj yuav pab tau nyob rau lub sijhawm luv luv thiab kho cov tsos mob hnyav ntawm tus kab mob. "

Igor, 23 xyoo, Anapa: "Txawm hais tias kuv tseem hluas, Kuv yuav tsum tau kho tus mob hnyav xws li mob ntshav qab zib. Kuv xav nco ntsoov tam sim ntawd kev kho mob tsis tsuas yog noj tshuaj. Kuv yuav tsum hloov kuv txoj kev ua neej, kho kuv li kev noj haus thiab suav nrog kev ua kis las thiab ntau tshaj plaws hauv kuv txoj haujlwm Kev siv lub cev ua haujlwm.Qhov tshuaj no pab txo cov tsos mob ntawm tus kab mob, uas cuam tshuam nrog kev nyob ib txwm. Kuv tsis tau pom tias muaj kev phiv dab tsi, kuv tsis hnov zoo li tsuas yog muaj cov tsos mob tshwm sim ntawm tus kab mob. eskers. "