Finlepsin ® qeeb qeeb (Finlepsin® retard)

Rau qhov no tshuaj thaiv pawgderivative dibenzazepinetseem yog yam ntxwv tshuaj tiv thaiv kab mob kev nkeeg, tshuaj tiv thaiv kab mob, tshuaj tua kab mob thiab analgesicnyhuv. Qhov kev txiav txim ntawm cov tshuaj muaj feem rau kev thaiv. voltage-gated sodium raws, pab txhawb kom muaj kev ruaj khov ntawm cov qog ua pa ntawm neurons ntau dhau, txo qis kev sib txuas ntawm kev zam txim thiab kev txwv tsis pub tawm ntawm cov dej ntawm neurons. Kev tso tawm ntawm neurotransmitter amino acid txo - glutamatemuaj cov txiaj ntsig zoo, uas pab txo qis qhov cuam tshuam ntawm cov hlab ntsha tsis zoo, thiab, yog li ntawd, qhov ntxim li yuav muaj kev pheej hmoo siab dua ntawm qaug dab peg.

Qhov ua tau zoo ntawm cov tshuaj tau tshwm sim hauv kev yooj yim lossis cov mob sib kis mob vwm, uas tuaj yeem nrog tus ntawv theem nrab kev hais dav dav thiab yog li ntawd. Tib lub sijhawm, qhov kev txo qis hauv cov tsos mob tau sau tseg. ntxhov siab, kev ntxhov siab, txob tausthiabtxhoj puab heev.

Cov tshuaj no yog tus yam ntxwv qeeb, tab sis puv kev nqus tauywj siab ntawm kev xaiv khoom noj. Qhov kev kub siab ntawm cov tshuaj hauv lub cev ua tiav hauv 12 teev nrog ib daim ntawv thov Finlepsin Retard 400 mg, thaum tswj kev ua kom zoo rau 4-5 teev. Nyob rau tib lub sij hawm, kev muaj siab sib npaug ntawm cov tshuaj nquag nyob hauv cov ntshav tau mus txog tom qab kev kho mob ntawm 1-2 lub lis piam. Txawm li cas los xij, qhov no yuav nyob ntawm cov yam ntxwv ntawm tus neeg mob metabolism: pib-induction ntawm cov enzyme hauv lub siab, hetero-induction los ntawm lwm cov tshuaj noj ib txhij, tus neeg mob tus mob, noj thiab sijhawm kho. Nws tau pom tias carbamazepine hla mus rau hauv niam cov kua mis thiab los ntawm qhov tsis haum xeeb.

Cov tshuaj noj tshuaj metabolism tshwm sim hauv daim siab nrog rau kev tsim cov tshuaj tseem ceeb: carbamazepine-10,11-epoxide - nquag thiab ua haujlwm sib xyaw nrog glucuronic acidCov. Raws li qhov tshwm sim ntawm cov txheej txheem hauv lub cev, qhov kev zom zaub mov tsis tshua muaj zog ntawm 9-hydroxymethyl-10-carbamoylacridane tau tsim, muaj peev xwm tsim tau nws tus kheej cov metabolism. Kev nqhis ntawm cov tshuaj yog feem ntau nqa tawm nyob rau hauv cov lus muaj pes tsawg leeg zis, ib nrab nrog quav.

Kev Taw Qhia Finlepsin

Cov cim tseem ceeb rau kev siv Finlepsin:

• ntau hom qaug dab peg
• neuralgia
• mob hauv cov leeg mob hauv cov neeg mob nrog mob ntshav qab zib
• cov sib txawv ntawm qhov muaj mob chua leeg - cramps, qaug dab peg, thiab lwm yam,
• haus dej cawv haus cawv
• kev nyuaj siab ntxhov plawv.

Cov Yuav Tsum Muaj

Finlepsin tsis yog qhov kho rau:

• kev tiv thaiv tsis haum rau nws cov khoom siv lossis tricyclic cov tshuaj tiv thaiv kab mob,
• kev ua txhaum ntawm cov pob txha mob hematopoiesis,
• sib quas ntus sib luag porphyria,
• AV thaiv,
• concomitant siv lithium npaj lossis MAO inhibitors.

Kev ceeb toom yog qhia nyob rau hauv kev kho mob ntawm cov neeg mob decompensated ntev lub plawv tsis ua haujlwm, dilution hyponatremia, mob siab thiab lub raum mob, cov neeg laus, nquag haus cawv, ua rau muaj pob txha hlwb txhaws, thaum noj qee yam tshuaj, prostate hyperplasia, mob siab intraocular, thiab lwm yam.

Kev phiv ntawm finlepsin

Raws li txoj cai, cov kev mob tshwm sim thaum kho nrog cov tshuaj no yuav tshwm sim vim kev haus ntau dhau los yog qhov txawv txav ntawm cov tshuaj nyob hauv lub cev. Feem ntau, qhov tshwm sim ntawm kev hloov pauv hauv kev ua haujlwm ntawm lub paj hlwb tau sau tseg: kiv taub hau,ataxia, nkees nkees, feem ntau tsis muaj zog, mob taub hau thiab yog li ntawd. Kev nthuav qhia kuj ua tau. kev fab tshuaj tsis haummuab ua piv txwv urticaria, erythrodermatawv nqaij pob thiab lwm cov tsos mob.

Hematopoietic thiab ntshav kev tuaj yeem tuaj yeem teb los ntawm: leukopenia, thrombocytopenia, eosinophilia, leukocytosis, lymphadenopathyCov. Qhov tshwm sim ntawm kev txhim kho kev sib txawv hauv cov hnyuv seem: xeev siab, ntuav, qhov ncauj qhuav, nce kev ua si ntawm gamma-glutamyl transferase, kev ua si thiab hepatic transaminases, zawv plab lossis cem quav.

Tsis tas li ntawd, kev cuam tshuam cuam tshuam nrog endocrine system thiab cov metabolism kuj yuav tshwm sim: kev o, dej tuav, nce phaus, ntuav, hyponatremia thiab yog li ntawd. Kev txhim kho ntawm kev tsis sib txawv ntawm cov haujlwm ntawm lub plawv thiab lub cev urogenital, cov leeg ua haujlwm thiab cov leeg plab ntawm lub plab thiab tsis paub yuav tsum txiav tawm.

Finlepsin ntsiav tshuaj, cov lus qhia rau kev siv (tus qauv thiab ntau npaum li cas)

Cov tshuaj no yog npaj rau cov thawj coj hauv lub qhov ncauj, tsis hais txog kev siv khoom noj.

Hauv kev kho mob qaug dab peg ntsiav tshuaj yog kho raws li kev kho mob monotherapy. Yog tias Finlepsin txuas rau cov tshuaj tiv thaiv kho mob, ces qhov no ua tiav maj mam, nruj me ntsis tswj kev siv tshuaj. Nyob rau hauv rooj plaub uas cov ntsiav tshuaj hla dhau, nws yuav tsum noj tam sim ntawd, vim tias muaj kev ncua, tab sis koj yuav tsum tsis txhob ntxiv daim ntawv hla nrog ob rab koob.

Raws li cov lus qhia rau kev siv Finlepsin Retard, cov neeg laus cov neeg mob thaum pib kho yog ib koob tshuaj 200-400 mg ib hnub ib zaug. Tom qab ntawd, maj mam nce ntxiv rau txoj kev ntau npaum li qhov ua tau, pub kom ua tiav kev ua hauj lwm zoo. Kev saib xyuas cov tshuaj txhua hnub yog - 800-1200 mg, lub sijhawm no muab faib ua 1-3 koob. Qhov siab tshaj plaws tau tso cai rau noj txhua hnub yuav tsum tsis pub ntau dua 1.6-2 g.

Rau cov menyuam yaus, cov koob tshuaj yuav tsum tau nyob ntawm lub hnub nyoog. Ib qho ntxiv, thaum nws nyuaj rau tus menyuam noj tag nrho cov ntsiav tshuaj, nws tuaj yeem zom, zom thiab yaj hauv ib qho kua me me.

Cov menyuam yaus 1-5 xyoos tau sau tseg rau 100-200 mg, maj mam muab cov tshuaj rau txhua hnub tau nce ntxiv kom ua tiav qhov zoo tshaj plaws.

Cov menyuam muaj 6-10 xyoo raug pom zoo kom pib kho nrog tshuaj rau lub cev txhua hnub Finlepsin Retard 200 mg, tom qab ntawd cov koob tshuaj kuj tseem nce zuj zus.

Kev muab tshuaj rau txhua hnub rau cov menyuam yaus 11-15 xyoos yog 100-300 mg. Tom qab uas nws tau maj mam nce ntxiv los ntawm 100 mg kom txog thaum qib siab zoo yog manifested.

Cov tshuaj nruab nrab txhua hnub saib xyuas: rau cov neeg mob me 1-5 xyoos, 200-400 mg, 6-10 xyoo hauv thaj tsam ntawm 400-600 mg, 11-15 xyoos, 600–1000 mg, uas tau muab faib ua ob peb koob tshuaj.

Lub sijhawm kho yog ncaj qha raws li cov cim thiab tus yam ntxwv ntawm tus neeg mob. Txawm li cas los xij, txhua qhov kev txiav txim siab ntsig txog kev kho yog qhov tseem ceeb ntawm tus kws kho mob. Feem ntau yog qhov teeb meem ntawm kev txo qhov koob tshuaj lossis kev txiav tu ncua cov tshuaj tau sib tham thaum tus neeg mob tsis muaj qaug dab peg 2-3 xyoos.

Kev txiav tsis tu ntawm kev kho mob cuam tshuam nrog txo qis koob tshuaj, ncua ntev dua 1-2 xyoos, nyob rau hauv kev tshuaj xyuas EEG tsis tu ncua. Hauv qhov no, menyuam yaus yuav tsum coj mus rau hauv qhov hnyav nce thiab hnub nyoog.

Thaum kho ntawm lwm yam kev cuam tshuam raws li kev taw qhia, qhov ntau thiab lub sijhawm ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob, coj mus rau hauv tus lej qhov nyuaj ntawm tus kabmob thiab tus neeg mob tshwj xeeb.

Noj ntau dhau

Nrog kev noj tshuaj ntau dhau ntawm Finlepsin, ntau cov tsos mob yuav tshwm sim, qhia txog qhov kev ua txhaum ntawm cov hlab ntsha leeg, hlab plawv thiab lub ntsws ua pa, cov kab mob hauv lub cev thiab cov kev txawv txav.

Qhov no yog ua pov thawj: kev tsim txom los ntawm lub hauv nruab nrab cov hlab hlwb, cuam tshuam, nkees nkees, ntxhov siab, hnov ​​ntxhias, hnov ​​qab, tsis pom kev, tachycardiakev ua haujlwm ntawm cov ntshav siab, tsaus muag, ua tsis taus pa ntawm lub ntsws, mob ntsws, ua kom ntuav, tso zis tawm, thiab lwm yam.

Nws tau raug tsim muaj tias tsis muaj tshuaj los kho rau kev noj ntau dhau, yog li ntawd, kev txhawb nqa kev kho mob tau nqa tawm nyob ntawm seb cov tsos mob tshwm sim, nyob rau hauv cov teeb meem nyuaj - hauv tsev kho mob.

Kev sib txuam

Kev sib xyaw ntawm cov tshuaj no nrog CYP3A4 inhibitors ua rau muaj kev nce zuj zus carbamazepine nyob rau hauv kev sib xyaw ua ke ntawm cov ntshav ntshav thiab kev txhim kho ntawm kev phiv tshuaj. Ua ke nrog inducers ntawm CYP3A4 feem ntau nrawm cov metabolism hauvcarbamazepine, txo nws cov concentration thiab kho cov nyhuv.

Ib txhij siv verapamil, diltiazem, felodipine, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide,danazole, desipramine, nicotinamide, li qub macrolides - erythromycin, josamycin, clarithromycin, troleandomycin, qee qhov azoles - itraconazole, ketoconazole thiab fluconazole tuaj yeem ua rau nce siab carbamazepinetab sisCov. Tib qho yeeb yam yog yam ntxwv ntawm terfenadine, loratadine, isoniazid, propoxyphenekua txiv kab ntxwv qaub, viral protease inhibitors. Hauv qhov no, kev hloov tshuaj thiab kev tswj hwm ntawm kev tswj hwm ntawm cov tshuaj hauv ntshav tau tsim nyog.

Ib qho kev sib xyaw ua ke yuav ua rau muaj kev sib txuam txo lossis nce nyob hauv kev ua kom pom tseeb. felbamate thiab carbamazepine.

Tsawg dua kev ua haujlwm carbamazepine tej zaum kuj: phenobarbital, primidone, metsuximide, phenytoin, fensuximide, theophylline, cisplatin, doxorubicin,rifampicin, clonazepam, valproic acid, valpromide, oxcarbazepine thiab ib tug xov tooj ntawm cov tshuaj ntsuab npaj uas muaj Hypericum perforatum.

Carbamazepine txo cov ntshav plasma concentration ntawm cov tshuaj xws li:clobazam, clonazepam, ethosuximide, primidone, digoxin, valproic acid, alprazolam, cyclosporine, tetracycline, haloperidol,qhov ncauj npaj muaj tshuaj estrogen thiab progesterone thiab yog li ntawd.

Nws yog tsim los uas tetracyclines tsis muaj zog kho kom zoo carbamazepineCov. Siv nrog tshuaj paracetamol nce kev pheej hmoo ntawm kev phiv tshuaj lom rau daim siab, txo cov tshuaj kho kom zoo. Ua ke nrog phenothiazines, pimozide, molindone, clozapine, haloperidol, thioxanthenes, maprotilinethiab tricyclic cov tshuaj tiv thaiv kev ntxhov siab txhim kho cov nyhuv inhibitory nyob rau ntawm cov leeg hlwb, ua kom tsis muaj zog tiv thaiv kev tiv thaiv ntawm cov tshuaj.

Yog li no, thaum Finlepsin raug samfwm rau cov neeg mob, nws yog qhov yuav tsum tau hais qhia tus kws khomob sai sai txog cov tshuaj twg lawv tseem noj.

Finlepsin cov lus piv txwv

Cov ntsiab lus zoo ntawm Finlepsin yog sawv cev los ntawm cov tshuaj: Actinval, Apo-Carbamazepine, Zagretol, Zeptol, Carbalepsin retard, Carbamazepine, Mazepin, Stazepin, Storilat, Tegretolthiab lwm tus.

Nws yog tsim los uas carbamazepinetxo cov tshuaj ethanol tiv thaiv. Tab sis kuj haus cawv thaum lub sij hawm cov kab mob uas cov tshuaj no tau qhia, peb tuaj yeem cia siab tias kev txhim kho ntawm kev phiv thiab ntau yam teeb meem.

Kev tshuaj xyuas rau Finlepsin

Feem ntau, cov neeg siv tawm tswv yim txog Finlepsin Retarduas lawv lossis lawv tus hlub yuav siv sij hawm ntau xyoo. Qee cov neeg mob txom nyem qaug dab peg, nco ntsoov tias kev noj cov tshuaj no undesirably cuam tshuam lawv cov kev txawj ntse, uas ua rau kev txhim kho ntawm kev tsis quav ntsej thiab cuam tshuam kev sib txuas lus. Txawm li cas los xij, txawm hais tias muaj cov tsos mob no, cov neeg mob lees paub qhov ua tau zoo ntawm cov tshuaj, cia koj tsis nco qab txog kev tawm tsam.

Muaj cov kev tshuaj xyuas thaum Finlepsin tau siv rau hauv kev kho mob los ntawm kev ntshai tsam cuam tshuam nrog kev ntshai ntawm qhib lossis, hloov chaw, kaw cov chaw. Raws li kev kho mob, feem ntau qhov ceeb ploj ploj, txawm li cas los xij, qee qhov kev tsis txaus ntseeg hauv lub gait tseem txhawj xeeb.

Yog li, Finlepsin yog ib qho ntawm cov tshuaj anticonvulsant thiab antiepileptic uas tau ua tiav zoo hauv kev siv tshuaj. Raws li cov kws tshaj lij, kev kho mob nrog cov cuab yeej tshwj xeeb no tso cai rau koj kom ua tiav cov txiaj ntsig tsis txaus ntseeg. Qhov loj tshaj plaws yog nruj me ntsis raws li txhua tus kws kho mob sau, hais txog qhov ntau npaum li cas ntawm cov tshuaj thiab kev hloov pauv hauv lub neej, kom paub meej vim li cas Finlepsin ntsiav tshuaj thiab coj lawv tsuas yog raws li kev taw qhia.

Tso tawm daim ntawv thiab cov tshuaj muaj pes tsawg leeg

Finlepsin Retard muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau kev tswj hwm qhov ncauj. Cov ntsiav tshuaj yog dawb, puag ncig, nrog kev pheej hmoo ntawm ib sab, ntim hauv hlwv ntawm 10 daim (5) hauv thawv ntawv thawv. Cov lus piav qhia nrog cov ncauj lus kom ntxaws txuas nrog hauv tshuaj.

Txhua lub ntsiav tshuaj muaj cov khoom xyaw nquag Carbamazepine 200 mg lossis 400 mg, ntxiv rau qee qhov kev pabcuam: microcrystalline cellulose, magnesium stearate, gelatin.

Tsuas tshuaj thiab tswj hwm

Cov koob tshuaj ntawm cov tshuaj tau teeb tsa ib tus zuj zus los ntawm tus kws kho mob, nyob ntawm tus yam ntxwv ntawm tus neeg mob lub cev thiab kev kuaj mob.

Thawj qhov tshuaj thawj zaug rau cov laus thiab cov hluas hnub nyoog 14 xyoos yog 100-400 mg ib hnub. Thaum tsis siv tshuaj kho kom tsis muaj txiaj ntsig lossis tsis muaj txiaj ntsig tsis txaus nyob hauv kev saib xyuas ntawm tus kws kho mob, qhov koob tshuaj tau nce ntxiv ntawm 200 mg rau ib hnub nrog rau ncua sijhawm ntawm 1 lub lis piam. Nyob ntawm qhov tshuaj txhua hnub, cov tshuaj tau muab faib ua 1-4 koob tshuaj, nws raug nquahu kom nqos cov ntsiav tshuaj tam sim ntawd nrog dej txaus.

Rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, koob tshuaj ntawm lub cev yog xam raws qhov ntsuas lub cev qhov hnyav - 10 mg / kg ib hnub, cov koob tshuaj tau muab faib ua 2-3 koob. Cov menyuam yaus hnub nyoog 6 txog 14 xyoos raug xaj 200 mg ntawm cov tshuaj ib hnub, qhov koob tshuaj tau muab faib 2 koob tshuaj. Yog tias cov nyhuv tsis txaus, tom qab 1 lub lis piam koob tshuaj yuav tau nce ntxiv los ntawm 100 mg. Qhov siab tshaj plaws niaj hnub noj rau cov menyuam yaus yog 1 g, rau cov neeg laus - 1200 mg.

Cev xeeb tub thiab lactation

Tsis muaj kev paub dhau los ntawm kev siv tshuaj yaj yeeb rau kev kho mob ntawm poj niam cev xeeb tub hauv thawj peb lub hlis thiab kev nyab xeeb ntawm carbamazepine rau tus me nyuam hauv plab tsis tau muaj pov thawj.

Kev siv ntawm Finlepsin Retard ntsiav tshuaj hauv qhov thib 2 thiab 3 txiav tawm ntawm cev xeeb tub yog ua tau tsuas yog muaj qhov cim loj heev, nyob rau hauv rooj plaub thaum cov txiaj ntsig rau leej niam dhau deb tshaj qhov kev pheej hmoo rau tus me nyuam hauv plab. Cov tshuaj muaj peev xwm siv tau hauv qhov tsis muaj kev txwv tsawg hauv cov qauv ntawm kev kho mob monotherapy.

Cov poj niam uas tau kho nrog Finlepsin Retard ntsiav tshuaj yuav tsum siv cov tshuaj muaj txiaj ntsig zoo kom tsis txhob muaj menyuam. Yog tias cev xeeb tub tau tshwm sim, tom qab ntawd tus poj niam yuav tsum sab laj nrog tus kws kho mob tam sim ntawd thiab tsum tsis txhob noj cov tshuaj ntawd.

Carbamazepine tuaj yeem tawm hauv cov kua mis, yog li nws tsis tsim nyog siv Finlepsin Retard ntsiav tshuaj hauv cov poj niam thaum lactation. Yog tias kev kho mob yog qhov tsim nyog, kev pub mis niam yog pom zoo kom cuam tshuam kom tsis txhob ua mob rau tus menyuam.

Sab sij huam

Thaum noj Finlepsin retard ntsiav tshuaj hauv cov neeg mob uas muaj kev cuam tshuam ntau cov tib neeg rau hauv cov tshuaj, cov kev mob tshwm sim yuav tsim:

• los ntawm cov leeg poob siab - tsaug zog, tsis quav ntsej rau qhov tshwm sim, ataxia, kiv taub hau, ob lub zeem muag, mob taub hau, yauv tsis zoo ntawm nqaj, cuam tshuam kev hloov chaw, paresis, pom kev tsis meej, neuritis, leeg tsis muaj zog, kev nyuaj siab, txob taus, cuam tshuam ntawm saj ntawm qib receptor, suab nrov thiab pob ntseg nrov hauv pob ntseg
• los ntawm qhov mob plab zom mov - glossitis, stomatitis, tsis qab los noj mov, kub siab, xeev siab, ntuav, mob siab, mob plab, nce kev ua haujlwm ntawm hepatic transaminases, tso quav,
• los ntawm cov hlab plawv - ua kom lub plawv tsis sib haum, atrioventricular block, mob vascular tsis txaus, thrombophlebitis, thromboembolism, kev txhim kho lub plawv tsis ua haujlwm,
• los ntawm cov ntshav hemopoietic plab hnyuv siab raum - kev txo qis ntawm cov leukocytes, platelets, agranulocytosis, ntshav liab, ntshav tsis txaus,
• endocrine system thiab metabolism - hyponatremia, tsis hnov ​​lus calcium uas tsis txaus, gynecomastia, galactorrhea, cov thyroid tsis ua hauj lwm, cov roj (cholesterol) ntau ntxiv, edema, kua tuav,
• los ntawm cov kab mob txeeb zig - lub raum tsis ua haujlwm, lub raum tsis ua haujlwm, interstitial nephritis,
• kev ua xua - tawv nqaij ua pob, khaus, ua paug ntawm cov qog ntshav, ua pob liab liab.

Yog tias ib lossis ntau cov kev mob tshwm sim, tus neeg mob yuav tsum sab laj nrog kws kho mob kom pab tswv yim.

Nosological kev faib tawm (ICD-10)

Cov Tshuaj Pharmacokinetics

Kev nqus tau qeeb tab sis ua tiav (kev noj mov tsis cuam tshuam loj npaum li cas thiab qhov nqus tau npaum li cas). Tom qab txhaj ib koob xwb C_max mus txog tom qab 32 teev. Nruab Nrab C_max cov tshuaj uas tsis hloov pauv tom qab siv ib koob tshuaj 400 mg ntawm carbamazepine ntau npaum li 2.5 μg / ml. C_ss cov tshuaj hauv plasma tau mus txog hauv 1-2 lub lis piam, qhov ua tiav ntawm kev ua tiav yog nyob ntawm tus neeg cov yam ntxwv ntawm cov metabolism (pib ntawm lub siab enzyme lub cev, hetero-induction los ntawm lwm cov tshuaj siv ib txhij), nrog rau tus neeg mob tus mob, noj tshuaj thiab lub sijhawm kho. Peb pom tias txhua tus neeg sib txawv hauv C qhov tseem ceeb._ss hauv kev kho kom zoo ntau yam: hauv cov neeg mob feem ntau, cov nqi no nyob ntawm 4 txog 12 μg / ml (17-50 μmol / l). Qhov ntau ntawm carbamazepine-10,11-epoxide (pharmacologically active metabolite) yog kwv yees li 30% ntawm kev mloog zoo ntawm carbamazepine.

Kev sib txuas lus nrog ntshav protein nyob hauv menyuam yaus - 55–59%, rau cov neeg laus - 70-80%.

Xauj V_d - 0.8-1.9 l / kg. Kev nqus yog tsim nyob rau hauv cerebrospinal kua thiab qaub ncaug, uas yog sib npaug rau cov nyiaj ntawm cov tshuaj nquag tsis txuam nrog cov protein (20-30%). Cais tau los ntawm qhov tsis muaj teeb meem. Kev sib xyaw hauv cov kua mis yog 25-60% ntawm qhov ntawd hauv ntshav.

Nws yog cov tshuaj tiv thaiv hauv lub siab, feem ntau nyob ntawm txoj kab kev epoxy nrog kev tsim cov metabolites lub ntsiab: nquag carbamazepine-10,11-epoxide thiab tsis muaj zog sib xyaw nrog glucuronic acid. Lub ntsiab isoenzyme uas muab cov biotransformation ntawm carbamazepine rau carbamazepine-10,11-epoxide yog cytochrome P450 (CYP3A 4). Raws li qhov tshwm sim ntawm cov teeb meem no, cov metabolite ntawm 9-hydroxymethyl-10-carbamoylacridane kuj tseem tsim, uas muaj cov haujlwm tsis muaj zog pharmacological.

Carbamazepine tuaj yeem tsim nws cov metabolism. T_1/2 tom qab qhov ncauj tswj hwm ntawm ib koob tshuaj yog 60-100 teev (thaj tsam li 70 teev), nrog kev noj tshuaj T ntev_1/2 txo qis vim kev pib ua haujlwm ntawm lub siab ua haujlwm enzyme mob siab. Tom qab cov tshuaj noj ib qhov ncauj ntawm carbamazepine, 72% ntawm cov koob tshuaj noj tau tso rau hauv cov zis thiab 28% hauv cov quav, nrog li 2% ntawm cov tshuaj tau tawm hauv cov zis ua cov tsis hloov pauv carbamazepine, kwv yees li 1% hauv daim ntawv 10.11-epoxy metabolite.

Tsis muaj pov thawj dab tsi qhia tau hais tias cov khw muag tshuaj ntawm carbamazepine hloov pauv ntawm cov neeg laus.

Cov Lus Qhia Finlepsin ® retard

epilepsy (thawj chua leeg chua leeg (tshwj tsis yog qhaj), ib feem ntawm cov qaug dab peg (qaug dab peg yooj yim thiab ob leeg chua leeg),

trigeminal neuralgia,

idiopathic glossopharyngeal neuralgia,

mob nrog mob txhab tawm ntawm cov hlab ntshav txhaws hauv ntshav qab zib, mob ntshav qab zib mob hlwb,

mob vwm ntau yam mob txha caj qaum,

mob ntsej muag zoo li qub nrog trigeminal neuralgia,

tonic mob nriaj, paroxysmal cuam tshuam ntawm kev hais lus thiab txav mus los (paroxysmal dysarthria thiab ataxia),

paroxysmal paresthesias thiab mob ntau ntawm qhov mob,

haus dej cawv haus cawv (kev ntxhov siab, qaug dab peg, siab dhau kev lom zem, pw tsaug zog),

kev puas siab puas ntsws (muaj kev cuam tshuam thiab schizoaffective cuam tshuam, psychoses, tsis meej ntawm lub limbic system).

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Finlepsin retard yog muaj nyob rau hauv daim ntawv ntawm lub caij nyoog-tso cov ntsiav tshuaj: los ntawm dawb nrog lub daj tint rau dawb, tiaj tus, puag ncig, cov npoo ntawm cov ntsiav tshuaj tau beveled, ib qho kev sib faib sib faib muaj qhov tsis sib xws yog thov rau txhua sab, 4 kev tsim tawm rau sab ntug (10 daim hauv cov hlwv, hauv duab los qhia ib pob ntawm 3, 4 lossis 5 blisters).

1 ntsiav tshuaj muaj:

• cov tshuaj nquag: carbamazepine - 200 lossis 400 mg,
• Cov khoom siv pabcuam: triacetin, copolymer Eudragit RS30D methyl methacrylate, ethyl acrylate thiab trimethylammonioethyl methacrylate (1: 2: 0.1), copolymer Eudragit L30D-55 (ethyl acrylate, methacrylic acid), crospovidone, siliconline collo, carbonium.

Cov lus qhia rau kev siv Finlepsin retard: txoj kev thiab ntau npaum li cas

Finlepsin retard ntsiav tshuaj 200 mg lossis 400 mg tau noj ntawm qhov ncauj thaum lub sijhawm lossis tom qab noj mov thiab ntxuav nrog cov dej txaus, kua txiv lossis lwm yam kua.

Yog tias tsim nyog, kev txiav txim siab ua ntej ntawm kev txhaj tshuaj ntawm cov kua hauv cov kua yog tso cai, nws lub cuab yeej ntawm pharmacological tsis ua txhaum.

Qhov koob tshuaj txhua hnub tau muab faib ua 1-2 koob tshuaj. Qhov siab tshaj plaws niaj hnub noj tshuaj yog 1.6 g.

Pom zoo kom noj tshuaj txhua hnub:

• kho kho tus mob vwm. Cov neeg laus: thawj koob tshuaj (ib zaug, thaum yav tsaus ntuj) yog 0.2-0.4 g, qhov koob tshuaj yuav tsum tau maj mam nce mus txog rau thaum tau txais qhov koob tshuaj uas tau muab cov tshuaj kho kom zoo rau hauv tus neeg mob. Cov koob tshuaj txij nkawm yog 0.8-1.2 g. Nws muab faib ua 2 koob: 0.2-0.6 g thaum sawv ntxov thiab 0.4-0.6 g thaum yav tsaus ntuj Cov menyuam yaus: thawj koob tshuaj rau cov menyuam muaj 6–15 xyoo (ib zaug, thaum yav tsaus ntuj) - 0.2 g, qhov koob tshuaj yog maj (0.1 g ib hnub) tau nce kom ua tiav cov txiaj ntsig zoo. Cov koob tshuaj saib xyuas rau cov menyuam yaus 6-10 xyoo yog 0.4-0.6 g, nws muab faib ua 2 koob tshuaj hauv qhov sib piv hauv qab no: thaum sawv ntxov - 0.2 g thiab yav tsaus ntuj - 0.2-0.4 g. cov menyuam hnub nyoog 11-15 xyoo yog 0.6-1 g: thaum sawv ntxov - 0.2-0.4 g, nyob rau yav tsaus ntuj - 0.4-0.6 g Lub sijhawm ntawm kev kho yog nyob ntawm kev kho mob ntawm tus neeg mob thiab tus neeg mob siab rau ntawm cov tshuaj Cov. Cov tshuaj ntawm Finlepsin retard raws li monotherapy yog nyiam dua. Kev qhia ntawm cov tshuaj mus rau hauv kev twb ua kev kho mob antiepileptic yuav tsum tau nqa tawm maj, yog tias tsim nyog, kho cov koob tshuaj ntawm concomitant tshuaj. Yog tias koj tsis nco qab noj ntxiv, koj tuaj yeem noj nws yog tias nws tsis sib raug zoo nrog kev tswj hwm ntawm lub caij nyoog ob zaug tshuaj. Tus kws kho mob txiav txim siab hloov lub siab mus rau Finlepsin retard kev kho mob, lub sijhawm siv lossis tso tseg kev siv tshuaj kho mob ib leeg zuj zus. Nws muaj peev xwm kom txo qis koob los yog tshem tawm cov tshuaj tsuas yog tsis ua tiav kev qaug dab peg hauv 2-3 xyoos. Kev kho yog tso tseg rau 1-2 xyoos, maj mam txo cov koob tshuaj nyob rau hauv kev tswj hwm ntawm electroencephalography. Hauv cov menyuam yaus, nrog qhov kev txo qis hauv ib hnub, nws yog ib qho tsim nyog yuav tsum xav txog qhov muaj hnub nyoog nce ntawm lub cev qhov hnyav,
• mob vwm epileptiform nrog ntau yam sclerosis: 0.2-0.4 g,
• trigeminal neuralgia thiab idiopathic glossopharyngeal neuralgia: thawj koob yog 0.2-0.4 g, nws nce tau qhia kom txog thaum qhov mob ploj tag. Qhov siab tshaj plaws txhua hnub yog 0.8 g. Kev saib xyuas qhov tshuaj yog feem ntau 0.4 g. Thawj koob tshuaj rau cov neeg mob laus lossis cov neeg mob rhiab rau kev ua ntawm carbamazepine yuav tsum yog 0.2 g ib hnub ib zaug,
• mob leeg mob hauv ntshav qab zib mob neuropathy: 0.2 g thaum sawv ntxov thiab 0.4 g nyob rau yav tsaus ntuj. Hauv qhov tshwj xeeb, kom ua tiav txoj kev kho mob kom zoo, Finlepsin retard yog qhia thaum sawv ntxov thiab yav tsaus ntuj thaum koob ntawm 0.6 g,
• kev kho mob ntawm haus dej haus cawv tawm hauv tsev kho mob: feem ntau 0.6 g (0.2 g thaum sawv ntxov thiab 0.4 g thaum yav tsaus ntuj), nyob rau hauv rooj plaub hnyav, 1.2 g hauv thawj ob peb hnub. Cov tshuaj tuaj yeem ua ke nrog lwm cov tshuaj uas siv los kho kev haus cawv. Koj tsis tuaj yeem ua ke Finlepsin retard nrog sedatives thiab hypnotics. Ua tib zoo saib xyuas tus neeg mob lub hlwb kom zoo. Txoj kev kho yuav tsum tau nrog soj ntsuam cov theem ntawm carbamazepine hauv ntshav ntshav,
• hlwb (kev kho mob thiab kev tiv thaiv): thawj koob tshuaj thiab txij nkawm yog 0.2-0.4 g. Qhov siab tshaj plaws niaj hnub noj yog 0.8 g.

Cov lus qhia tshwj xeeb

Qib ntawm kev cuam tshuam ntawm carbamazepine rau kev txhim kho ntawm cov neeg muaj mob tiv thaiv kev mob, tshwj xeeb tshaj yog thaum ua ke nrog cov tshuaj tiv thaiv kev tiv thaiv, tsis tau tsim.

Kev txhim kho cov kev mob tshwm sim los ntawm cov hlab ntsha hauv nruab nrab tuaj yeem tshwm sim los ntawm qhov kev noj qab haus huv ntau dhau ntawm cov tshuaj lossis cov kev hloov pauv nyob hauv qib ntawm kev xav ntawm carbamazepine hauv cov ntshav ntshav.

Kev teem sij hawm ntawm Finlepsin retard tsuas yog ua tau yog tias tus kws kho mob tau saib xyuas tsis tu ncua rau tus neeg mob lub caij.

Tawm tsam keeb kwm ntawm kev siv cov tshuaj, muaj kev pheej hmoo ntawm kev tua tus kheej lossis lub siab xav ua, cov txheej txheem ntawm kev tshwm sim uas tsis paub. Cov neeg mob, lawv tsev neeg thiab cov neeg ua haujlwm yuav tsum ceeb toom txog qhov no thiab tias lawv yuav tsum nrhiav kev kho mob sai sai yog tias muaj cov tsos mob ntawm kev tua tus kheej.

Txhawm rau xaiv ib tus neeg pib thiab kev saib xyuas cov tshuaj uas muab cov txiaj ntsig zoo, nws yog qhov tsim nyog los txiav txim siab txog qib carbamazepine hauv ntshav ntshav, tshwj xeeb tshaj yog thaum Finlepsin raug tshuaj ua ib feem ntawm kev sib txuam, vim hais tias nrog kev nrawm metabolism tshwm sim los ntawm induction ntawm microsomal daim siab enzymes lossis kev cuam tshuam ntawm ib txhij siv cov tshuaj, tus neeg mob yuav tsum tau txhaj ib lub koob txawv txawv raws li kev pom zoo koob tshuaj.

Kev tshem tawm sai sai ntawm Finlepsin retard tuaj yeem ua rau qaug dab peg, yog li yog tias koj yuav tsum cuam tshuam tus neeg mob txoj kev kho sai, koj yuav tsum hloov mus rau lwm cov tshuaj tiv thaiv kev puas tsuaj nyob rau hauv kev tuav pov hwm (iv) lossis qhov quav ntawm diazepam, phenytoin (iv) lossis lwm yam kev qhia tau hais hauv cov xwm txheej no.

Kev siv dej cawv yog contraindicated rau tus keeb kwm yav dhau los ntawm kev siv tshuaj.

Txoj kev hloov mus rau kev kho mob nrog carbamazepine yog tsim los ntawm maj mam txo cov koob tshuaj uas tau noj yav tas los tshuaj tiv thaiv kab mob.

Cov poj niam uas muaj hnub nyoog yug me nyuam yuav tsum tsis txhob siv cov tshuaj hormonal qhov kev tiv thaiv, vim tias lawv tsis muab txoj kev tiv thaiv kom ntseeg tau thiab tuaj yeem ua rau intermenstrual los ntshav.

Cov tshuaj yuav tsum nrog kev tshuaj xyuas lub siab ua haujlwm tsis tu ncua, tshwj xeeb tshaj yog rau cov neeg laus thiab cov neeg mob uas muaj keeb kwm muaj kab mob siab. Nrog txoj kev loj hlob ntawm daim siab mob siab, Finlepsin retard yuav tsum tau muab tshem tawm sai li sai tau.

Thaum sau tshuaj rau thawj 4 lub lis piam ntawm kev kho mob, txhua lub lim tiam thiab tom qab ntawd ib zaug txhua 4 lub lis piam, nws yog qhov yuav tsum tau kuaj ntshav seb puas muaj cov ntshav platelet, reticulocytes, qib hlau, urea, thiab cov ntshav electrolytes concentration. Tsis tas li ntawd, ib qho tseem ceeb tso zis, yuav tsum muaj electroencephalography.

Txoj kev kho yuav tsum tau tsum tsis ua ntxiv rau cov mob leukopenia uas yog cov kab mob tshwm sim ntawm cov kab mob sib kis los yog leukopenia.

Cov tsos mob ntawm cov tawv nqaij tsis haum nyob rau hauv daim ntawv sib cais macular lossis maculopapular pob feem ntau tsis tas yuav tshem tawm ntawm Finlepsin retard, cov tsos mob ploj lawv tus kheej, suav nrog tom qab txo cov koob tshuaj. Lub sijhawm no, tus neeg mob xav tau kev saib xyuas ntawm tus kws kho mob. Yog tias koj muaj kev tiv thaiv qhov tsis haum lub cev, cov tsos mob ntawm Stevens-Johnson syndrome lossis Lyell syndrome, koj yuav tsum tsis txhob noj cov tshuaj noj.

Tus kws kho mob yuav tsum qhia tus neeg mob txog kev txhim kho kev mob tshwm sim ntawm lub cev, qhov tshwm sim ntawm cov tsos mob thaum ntxov uas yuav kub cev, tawm pob, mob caj pas, txhaws ntawm lub qhov ncauj ntawm qhov ncauj, tshwm sim ntawm hematomas, hemorrhages lossis purpura. Txog kev kuaj mob raws sijhawm, koj yuav tsum tau sab laj nrog kws khomob.

Ua ntej pib txoj kev kho mob, tus neeg mob raug nquahu kom kuaj mob tsis txaus, nrog rau kev ntsuas ntawm qhov mob siab thiab soj ntsuam ntawm pob nyiaj. Nrog kev ua haujlwm siab nyob rau siab, nws yuav tsum tau soj ntsuam tas li thaum noj cov carbamazepine.

Hauv cov kab mob hnyav ntawm cov hlab plawv, ua rau lub siab thiab (lossis) raum, nrog rau cov neeg muaj hnub nyoog laus, nws raug nquahu kom siv Finlepsin retard hauv kev txhaj tshuaj qis.

Kev txiav txim siab tsis tu ncua ntawm cov qib carbamazepine hauv plasma yog qhov xav tau yog tias muaj kev ua txhaum ntawm kev ua txhaum ntawm nws txoj kev nqus, los tswj cov kev tsis tu ncua ntawm cov tshuaj noj los ntawm tus neeg mob, nrog ntse nce rau ntawm qaug dab peg, thaum cev xeeb tub, hauv kev kho mob ntawm menyuam yaus, nrog cov cim ntawm kev phiv tshuaj lom.

Yeeb tshuaj sib cuam tshuam

Nrog tib lub sijhawm siv Finlepsin retard:

• inhibitors ntawm isoenzyme CYP3A4: tuaj yeem pab txhawb kev nce qib ntawm carbamazepine hauv cov ntshav ntshav thiab kev txhim kho ntawm cov kev tsis haum,
• Qhov tsim nyog ntawm CYP3A4 isoenzyme: tuaj yeem ua rau muaj kev nrawm ntawm cov metabolism hauv carbamazepine thiab txo qis hauv nws cov plasma concentration thiab kho cov nyhuv. Txawm li cas los xij, thaum lawv tso tseg, ib qho kev nce ntxiv ntawm qhov kev tso tawm ntawm carbamazepine tshwm sim, txij li nws tus nqi ntawm biotransformation poob qis,
• MAO inhibitors: tuaj yeem ua rau kev loj hlob ntawm hyperthermic thiab hypertensive crises, qaug dab peg, tuaj yeem ua rau neeg tuag taus, yog li ntawd, cov sijhawm nruab nrab ntawm lawv cov kev nkag yuav tsum yog tsawg kawg ob lub lis piam,
• lithium npaj: ua rau kev nce hauv cov nyhuv neurotoxic ntawm txhua cov tshuaj,
• verapamil, nicotinamide, diltiazem, desipramine, felodipine, danazole, dextropropoxyphene, acetazolamide, viloxazine, cimetidine, fluoxetine, fluvoxamine, macrolides - clarithromycin, josamycin, troleandomycin, erythromucinaz, erythromucinaz , propoxifene, ritonavir thiab lwm cov protease inhibitors rau kev kho mob ntawm tib neeg cov tshuaj tiv thaiv kab mob kis tau tus kab mob: nce qhov kev xav ntawm carbamazepine hauv ntshav ntshav, yog li ntawd, saib xyuas qib ntawm carbamazepine hauv ntshav lossis kho ntawm nws cov koob tshuaj regimen,
• valproic acid, primidone: tshem tawm cov carbamazepine los ntawm kev sib txuas nrog cov ntshav plasma, tuaj yeem nce qhov siab ntawm pharmacologically nquag metabolite (carbamazepine-10,11-epoxide) thiab kev txhim kho ntawm kev phiv loj heev,
• phenobarbital, primidone, phenytoin, metsuximide, fensuximide, rifampicin, theophylline, cisplatin, doxorubicin, clonazepam, valpromide, oxcarbazepine, valproic acid, kev npaj uas muaj St. John lub wort perforated: tuaj yeem pab txo qis ntawm cov tshuaj,
• felbamate: ua rau txo qis ntawm cov carbamazepine thiab qhov nce ntawm cov ntsiab lus ntawm carbamazepine-10,11-epoxide nyob rau hauv cov ntshav ntshav, ib txhij txo qis hauv kev saib xyuas hauv cov ntshav cov ntshav thiab cov nyhuv ntawm felbamate yog ua tau,
• isotretinoin: hloov kho qhov tsis zoo thiab (lossis) kev tshem tawm cov carbamazepine, carbamazepine-10,11-epoxide,
• phenothiazine, pimozide, thioxanthenes (chlorprotixen), molindone, haloperidol, maprotiline, clozapine, tricyclic antidepressants: ua rau cov tshuaj tiv thaiv tsis haum, ua rau muaj kev cuam tshuam ntawm lub hauv nruab nrab cov hlab hlwb,
• clobazam, clonazepam, prednisone, digoxin, ethosuximide, prednisolone, valproic acid, prednisolone, alprazolam, dexamethasone, cyclosporine, methadone, doxycycline, haloperidol, theophylline, qhov ncauj tiv thaiv kab mob nrog estrorochenoric, orarromeric, tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv. ), topiramate, lamotrigine, tricyclic antidepressants (amitriptyline, imipramine, clomipramine, nortriptyline), clozapine, oxcarbazepine, tiagabin, protease inhibitors - indinavir, ritonavir thiab saquinavir, levothyroxine, b calcium channel locators dihydropyridine derivatives (felodipine), midazolam, olanzapine, tramadol, praziquantel, risperidone, ziprasidone, itraconazole: txo lawv cov plasma ntau ntau thiab lawv cov txiaj ntsig kho,
• tetracyclines: tej zaum yuav ua rau cov nyhuv tshuaj carbamazepine tsis muaj zog,
• myelotoxic tshuaj: ua rau muaj zog hematotoxic tshwm sim ntawm carbamazepine,
• tsis ncaj ntawm anticoagulants, tshuaj tiv thaiv hormonal, folic acid, praziquantel: nrawm koj cov metabolism,
• paracetamol: ua kom nrawm nws cov metabolism, uas ua rau muaj kev nce ntxiv ntawm kev pheej hmoo ua rau lub siab thiab txo qis hauv kev kho kom zoo ntawm paracetamol,
• hydrochlorothiazide, furosemide (diuretics): pab txhawb kev txhim kho hyponatremia nrog kev ua haujlwm hauv chaw kuaj mob,
• pancuronium thiab lwm yam tsis-depolarizing cov leeg ua kom tsis muaj zog: ua kom tsis muaj zog, ua kom haum, yuav tsum tau kho kom haum,
• cov thyroid hormones: tuaj yeem txhim kho kev tshem tawm,
• enflurane, halothane, fluorotan (tshuaj loog): nrawm koj cov metabolism, ua rau muaj kev phom sij rau hepatotoxic zoo,
• methoxyflurane: ua rau muaj kev tsim tawm ntawm nws cov nephrotoxic metabolites,
• isoniazid: txhim kho nws cov nyhuv hepatotoxic,
• ethanol: exacerbates nws cov nyhuv.

Cov duab analogues ntawm Finlepsin retard yog Finlepsin, Carbamazepine, Apo-Carbamazepine, Carbalepsin retard, Zagretol, Zeptol, Mazepin, Tegretol, Stazepin, Storilat.

Dab tsi yog Finlepsin Retard

Finlepsin, sau rau ntawm lub radar ua Finlepsin retard, zwm rau pawg pharmacological ntawm cov tshuaj antiepileptic uas tswj kev ua viav vias, daws kev qaug dab peg, mob thiab lwm yam kev mob ntawm neuralgia. Cov tshuaj tom qab pib ntawm kev tswj hwm muaj cov tshuaj anticonvulsant, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv analgesic.

Cov neeg muaj kab mob neuralgic nco ntsoov tias qhov mob txo qis, ntxhov siab poob qis. Cov kev ua haujlwm ntawm Finlepsin pab cuam tshuam rau cov muaj peev xwm rov qab los ntawm sodium raws, ua kom lub cev puas ntawm cov hlab hlwb neurons, txo cov kev ua kom tiav ntawm qhov tsis haum, thiab txo qhov ntxim nyiam ntawm kev txhim kho thiab rov muaj mob vwm dua.

Lub thoob ntiaj teb tsis yog lub npe ntawm cov tshuaj, lossis INN - carbamazepine, yog Finlepsin cov tshuaj nquag. Raws li cov koom haum pab siv:

• talcum hmoov
• ammonium methacrylate,
• magnesium stearate,
• crospovidone
• silicon oxide
• nkaws.

Tom qab 1-2 hnub ntawm kev tswj hwm, carbamazepine yog maj mam nqus rau hauv lub cev, thiab tom qab ib lim piam tus neeg mob ntshav txaus rau cov nyhuv tshuaj. Nws muaj peev xwm nkag mus rau hauv qhov chaw tiv thaiv kab mob, yog li Finlepsin yuav tsum ceev faj thaum cev xeeb tub, nco ntsoov sab laj nrog cov kws kho mob.

Tso Tawm Cov Ntawv

Finlepsin muaj nyob rau hauv daim ntawv daj lossis dawb ntsiav tshuaj muaj lub zog ntev, nrog ntau dua ntawm 200 thiab 400 mg ntawm cov tshuaj nquag. Txhua lub hlwv muaj 10 daim. Cov uas tau noj tshuaj tsawg dua cov tshuaj feem ntau yog rau cov menyuam yaus thiab cov neeg muaj teeb meem me hauv lub cev thaum pib kho, thiaj li tsis ua rau muaj kev mob hnyav.

Tom qab lub cev tau hloov kho tag nrho, qhov koob tshuaj tau nce ntxiv ntawm kev txiav txim siab ntawm tus kws kho mob uas tau saib xyuas tus neeg mob kom txog thaum cov txiaj ntsig xav tau. Txais tos ntawm Finlepsin-400 kuj pom zoo kom pib nrog 0.5 ntsiav tshuaj, tau ua tib zoo kawm cov lus qhia thiab pom tias lwm cov tshuaj thiab cov hau kev ntawm kev kho mob ua ke nrog nws. Hauv ib lub tsev muag tshuaj, Finlepsin ntsiav tshuaj muaj muag hauv cov duab los qhia ntawm 3, 4, 5 blisters.

Tsuas tshuaj thiab tswj hwm

Yog tias tsis muaj cov lus qhia tshwj xeeb ntawm koj tus kws kho mob, cov kev noj tshuaj hauv qab no yog siv tau rau finlepsin 200 retard. Thov ua raws li cov koob tshuaj uas koj tus kws kho mob sau tseg, vim hais tias txwv tsis pub finlepsin 200 retard yuav tsis muaj kev kho kom zoo!

Ntau npaum li cas thiab ntau npaum li cas yuav tsum koj noj finlepsin 200 retard

Kev kho nrog finlepsin 200 retard pib ua tib zoo, sau tshuaj rau hauv cov tshuaj tsawg kawg ntawm tus kheej rau txhua tus neeg mob, nyob ntawm seb qhov xwm txheej thiab mob hnyav ntawm tus kab mob. Tom qab ntawd cov koob tshuaj tau maj mam nce kom txog thaum siv tshuaj kho kom zoo tiav los txog. Qhov zoo tshaj plaws ntawm lub khob tshuaj rau tus neeg mob, tshwj xeeb tshaj yog nrog kev sib txuam, yog txiav txim siab los ntawm nws cov ntshav theem. Raws li cov kev paub ntau zuj zus, kev kho tshuaj concentration ntawm finlepsin 200 retard hauv ntshav yog 4–12 μg / ml.

Hloov ib qho tshuaj antiepileptic nrog finlepsin 200 retard yuav tsum ua maj mam ua, txo cov koob tshuaj ntawm cov tshuaj ua ntej siv. Yog tias ua tau, tus kab mob antiepileptic tsuas yog siv rau kev kho mob monotherapy. Lub chav kawm ntawm txoj kev kho yog saib xyuas los ntawm tus kws kho mob tshwj xeeb.

Feem ntau lees txais ntau npaum li cas yog 400–1200 mg ntawm finlepsin 200 retards ib hnub, uas tau muab faib ua 1-2 ib zaug ib hnub. Tshaj dhau qhov kev txhaj tshuaj txhua hnub ntawm 1200 mg tsis pom zoo. Qhov siab tshaj plaws txhua hnub koob tshuaj yuav tsum tsis pub tshaj 1600 mg, vim tias cov koob tshuaj ntau dua tuaj yeem nce tus naj npawb ntawm kev phiv.

Qee qhov, cov koob tshuaj uas xav tau rau kev kho mob tuaj yeem ua rau txawv txav los ntawm cov lus pom zoo pib thiab txij nkawm, piv txwv, vim muaj cov metabolism nrawm nrawm vim yog lub induction ntawm microsomal daim siab enzymes los yog vim muaj tshuaj nyob hauv kev kho ua ke.

Yog tias tsis muaj cov lus qhia tshwj xeeb los ntawm kws kho mob, lawv tau coj los ntawm cov qauv hauv qab no ntawm kev siv yeeb tshuaj:

Anticonvulsant kev kho mob

Feem ntau, hauv cov neeg laus, thawj koob tshuaj 1–2 ntsiav tshuaj ntawm retard (sib haum rau 200-400 mg ntawm carbamazepine) yog maj mam nce ntxiv rau kev saib xyuas ntawm 4-6 ntsiav tshuaj ntawm retard (sib haum rau 800–1200 mg ntawm carbamazepine).

Feem ntau, cov koob tshuaj saib xyuas ntawm carbamazepine rau cov menyuam yaus qhov nruab nrab 10-20 mg / kg lub cev hnyav ib hnub.

Cov sijhawm noj tshuaj hauv qab no yog kev pom zoo.

Cov neeg laus tau tuaj noj thaum sawv ntxov / yav tsaus ntuj200-300 mg thaum yav tsaus ntuj 200-600 mg 400-600 mg Cov menyuam raug khosaib ntawv los ntawm 6 txog 10 xyoo nyob rau yav tsaus ntuj150-200 mg thaum tsaus ntuj200 mg thaum sawv ntxov 200-400 mg 11 rau 15 xyoos thaum sawv ntxov / yav tsaus ntuj150-200 mg thaum tsaus ntuj200-400 mg 400-600 mg

Rau cov menyuam yaus hnub nyoog qis dua 6 xyoo, rau kev kho mob thawj zaug thiab txhawb nqa, cov ntsiav tshuaj ntawm qhov tsis ua raws sij hawm muaj. Vim yog qhov kev paub tsis txaus uas tau txais nrog cov ntsiav tshuaj rov qab, lawv tsis pom zoo rau cov menyuam yaus hnub nyoog no.

Kev tiv thaiv ntawm kev txhim kho kev qaug dab peg nrog kev haus cawv haus cawv hauv tsev kho mob

Qhov tshuaj nruab nrab txhua hnub yog 1 ntsiav tshuaj ntawm retard thaum sawv ntxov, thaum yav tsaus ntuj 2 ntsiav tshuaj ntawm retard yog cov tshuaj (sib haum rau 600 mg ntawm carbamazepine). Hauv cov xwm txheej hnyav, hauv thawj hnub, cov koob tshuaj tuaj yeem raug nce ntxiv rau 3 ntsiav tshuaj ntawm retard 2 zaug hauv ib hnub (sib piv rau 1200 mg ntawm carbamazepine).

Finlepsin 200 retard yuav tsum tsis txhob muab tso nrog cov tshuaj sedative-hypnotic. Ua raws li kev kho mob hauv tsev kho mob, txawm li cas los xij, yog tias tsim nyog, finlepsin 200 retard tuaj yeem ua ke nrog lwm cov tshuaj uas siv los kho cawv cawv.

Thaum kho, nws yog qhov yuav tsum tau soj ntsuam cov ntsiab lus ntawm finlepsin 200 retards hauv cov ntshav ntshav.

Hauv kev sib txuas nrog kev txhim kho kev mob tshwm sim los ntawm lub hauv nruab nrab thiab lub hlwb tsis zoo (saib cov kev tshwm sim ntawm kev haus cawv hauv tshooj "Cov Kev Cuam Tshuam"), kev soj ntsuam kev soj ntsuam tau zoo tau tsim rau cov neeg mob.

Ua rau mob hlwb neuralgia, genuin glossopharyngeal neuralgia

Thawj koob tshuaj yog 1-2 ntsiav tshuaj ntawm retard (sib haum rau 200-400 mg ntawm carbamazepine), uas, kom txog rau thaum qhov mob ploj tag, yog nce los ntawm qhov nruab nrab ntawm 2–4 ntsiav tshuaj ntawm retard (sib haum rau 400-800 mg ntawm carbamazepine), uas muab faib rau hauv 1-2 koob tshuaj hauv hnub. Tom qab ntawd, hauv qee qhov ntawm cov neeg mob, kev kho mob tuaj yeem txuas ntxiv nrog kev kho qis dua, uas tseem tuaj yeem tiv thaiv kev tawm tsam ntawm kev mob ntawm 1 ntsiav tshuaj ntawm retard 2 zaug hauv ib hnub (sib raug rau 400 mg ntawm carbamazepine).

Rau cov neeg laus thiab cov neeg mob tsis haum, finlepsin 200 retard yog kho hauv thawj koob ntawm 1 ntsiav tshuaj ntawm retard ib hnub ib zaug (sib raug rau 200 mg ntawm carbamazepine).

Hnov mob ntshav qab zib neuropathy

Qhov nruab nrab txhua hnub koob tshuaj yog 1 ntsiav tshuaj rov qab thaum sawv ntxov thiab 2 ntsiav tshuaj rov qab yav tsaus ntuj (sib haum rau 600 mg ntawm carbamazepine). Hauv qee qhov tshwj xeeb, finlepsin 200 retard tuaj yeem kho nyob rau hauv ib koob ntawm 3 ntsiav tshuaj ntawm retard 2 zaug hauv ib hnub (sib nug rau 1200 mg ntawm carbamazepine).

Kab mob vwm uas huam ntau yam mob sclerosis

Qhov nruab nrab txhua hnub koob tshuaj yog 1-2 retard ntsiav tshuaj 2 zaug hauv ib hnub (sib xyaw rau 400-800 mg ntawm carbamazepine).

Kev kho thiab tiv thaiv kev mob hlwb

Thawj koob tshuaj, uas feem ntau kuj txaus raws li kev saib xyuas txij nkawm, yog 1-2 retard ntsiav tshuaj ib hnub (sib xws rau 200-400 mg ntawm carbamazepine). Yog tias tsim nyog, cov koob tshuaj no tuaj yeem raug ntxiv rau 2 ntsiav tshuaj ntawm retard 2 zaug hauv ib hnub (sib xyaw rau 800 mg ntawm carbamazepine).

Cov neeg mob uas muaj cov kab mob plawv heev, mob rau daim siab thiab lub raum, nrog rau cov neeg laus yuav tau txais tshuaj tsawg dua ntawm cov tshuaj.

Yuav ua li cas thiab thaum twg koj yuav tsum coj finlepsin 200 retard

Cov ntsiav tshuaj rov qab yog nruab nrog qhov zaws sib faib, lawv tau noj thaum lub sijhawm noj mov lossis tom qab noj mov, ntxuav nrog kom muaj kua txaus (piv txwv li, khob dej).

Cov ntsiav tshuaj rov qab tuaj yeem nqa tom qab lawv thawj qhov kev cais tawm hauv dej (hauv qhov qauv ntawm kev ncua). Lub caij nyoog ntev mus ntev tsawv tom qab lub ntsiav tshuaj disintegrates hauv dej.

Qee qhov xwm txheej, muab faib rau cov koob tshuaj txhua hnub rau 4-5 koob tshuaj ib hnub ua rau muaj txiaj ntsig tshwj xeeb. Rau qhov no, ntau npaum li cas ntawm kev txiav txim siab uas tsis yog lub caij nyoog ntev yog qhov zoo tshaj plaws.

Ntev npaum li cas koj yuav tsum coj finlepsin 200 retard

Lub sijhawm siv yog nyob ntawm qhov ntsuas thiab tus neeg teb ntawm tus neeg mob rau cov tshuaj.

Epilepsy kho tau ntev. Tus kws kho mob tshwj xeeb yuav tsum txiav txim siab hloov chaw ntawm tus neeg mob mus rau finlepsin 200 retard, lub sijhawm siv thiab nws tshem tawm hauv txhua kis. Feem ntau, koj tuaj yeem sim txo qis ntawm cov tshuaj los yog txiav tawm tag nrho cov kev kho mob tsis muaj ua ntej tshaj li tom qab 2-3 xyoo tsis muaj mob chua leeg.

Txoj kev kho tau raug tso tseg los ntawm kev txo qis zuj zus me me hauv lub sijhawm li 1-2 xyoo. Hauv qhov no, menyuam yuav tsum xav txog qhov nce hauv lub cev nyhav. Cov ntsuas qhov EEG yuav tsum tsis txhob ua kom qis.

Hauv kev kho mob ntawm neuralgia, nws tau muaj txiaj ntsig los muab tshuaj finlepsin 200 retard nyob rau hauv kev saib xyuas txij nkawm, tsuas yog txaus los daws qhov mob, rau ob peb lub lis piam. Los ntawm kev ceev faj txo qis dua qhov koob tshuaj, nws yog ib qho tsim nyog yuav tsum txiav txim siab seb puas muaj kev zam los ntawm cov tsos mob ntawm tus mob. Nrog kev rov pib dua ntawm kev mob ntxiv, kho yog txuas ntxiv nrog cov koob tshuaj txij nkawm dhau los.

Lub sijhawm kho mob rau mob ntshav qab zib neuropathy thiab mob qaug dab peg hauv ntau yam sclerosis yog tib yam li rau neuralgia.

Kev kho mob ntawm kev haus cawv haus syndrome nrog finlepsin 200 theem ntev ntev tau raug nres los ntawm kev txo qis koob tshuaj ntau dua lub sijhawm 7-10 hnub.

Kev tiv thaiv theem manic-depressive yog nqa tawm mus ntev.

Yuam kev ntawm kev siv cov tshuaj thiab overdose

Yog tias koj tsis nco qab noj ib zaug ntawm cov tshuaj, tom qab koj pom nws tam sim ntawd, siv tam sim ntawd. Yog tias sai sai tom qab no koj yuav tsum noj tshuaj ntxiv tom qab, tom qab ntawd koj yuav hla nws, thiab tom qab ntawd sim rov nkag mus rau koj cov tshuaj noj kom raug. Txawm li cas los xij, tom qab ib qho hnov ​​qab tsis nco qab lawm, tsis txhob noj ob zaug koob ntawm finlepsin 200 retard. Yog tias tsis ntseeg, thov hu rau koj tus kws kho mob kom pab!

Dab tsi koj yuav tsum xav txog yog tias koj xav cuam tshuam lossis ntxov ntxov tso tseg kev kho mob

Hloov cov koob tshuaj rau koj tus kheej lossis tseem txwv tsis pub siv tshuaj yam tsis tau saib xyuas kev kho mob yog txaus ntshai! Hauv qhov no, cov tsos mob ntawm koj tus kab mob tuaj yeem rov ua dua. Ua ntej koj tsum tsis noj finlepsin 200 rov qab koj tus kheej, koj yuav tsum sab laj nrog koj tus kws kho mob txog qhov no.

Yuav ua li cas yog tias finlepsin 200 retard tau tshwm sim hauv ntau qhov ntau

Kev siv ntau dhau ntawm cov tshuaj yuav tsum muaj kev kho mob thaum muaj xwm ceev. Daim duab overdose ntawm finlepsin 200 retard yog pom los ntawm kev nce ntxiv hauv cov kev mob tshwm sim, xws li tshee tshee (tshee tshee), qaug dab peg uas tshwm sim thaum lub hlwb zoo siab (tonic-clonic convulsions), ntxhov siab, zoo li ua pa thiab mob plawv nrog feem ntau txo (qee zaum kuj nce siab) ntshav siab, nce lub plawv dhia (tachycardia) thiab cuam tshuam hauv kev tsis txaus siab hauv lub plawv (atrioventricular block, ECG hloov), tsis hnov ​​qab nco txog ua pa raug ntes thiab mob raug ntes. Hauv cov xwm txheej cais, kab mob leukocytosis, leukopenia, neutropenia, glucosuria lossis acetonuria tau pom, uas tau tsim los ntawm cov kev ntsuas tsis hloov ntawm kev kuaj sim.

Tsis muaj ib qho tshuaj tshwj xeeb rau kev kho mob ntawm kev mob hnyav nrog finlepsin 200 retard. Kev kho mob ntawm kev siv tshuaj ntau dhau ntawm finlepsin 200 retards, raws li txoj cai, yog nqa tawm nyob ntawm kev ua yeeb yam mob hauv tsev kho mob.

Pom cov kev mob tshwm sim ntau zaus tshwm sim nrog kev kho mob sib xyaw nrog kev kho mob hlwb. Nyob ntawm qhov koob tshuaj thiab feem ntau thaum pib kho, cov kev mob tshwm sim tom qab no tuaj yeem tshwm sim:

Kev Tsa Hauv Nruab Nrab / Lub Siab

Stupor ntawm nco qab, tsis meej pem nco qab (tsaug zog), kiv taub hau, qaug zog, tsis hnov ​​qab thiab txav (cerebellar ataxia) thiab mob taub hau tuaj yeem tshwm sim. Cov neeg laus yuav ua rau muaj kev ntxhov siab thiab ntxhov siab.

Nyob rau hauv qhov teeb meem raug rho tawm, muaj kev ntxhov siab tsis zoo, muaj tus cwj pwm txhoj puab heev, tsis nco qab xav, ua rau lub siab tsis xav ua qhov zoo, nrog rau kev cuam tshuam hauv kev xav (pom kev) thiab tinnitus tau pom. Thaum kho nrog finlepsin 200 retard, cov hlwb tsis xis nyob yuav qhib tau.

Qhov tshwm sim hauv lub cev feem ntau tsis tshua tshwm sim, xws li co co co, mob pob tw, lossis txhaws qhov muag (nystagmus). Tsis tas li ntawd, nyob rau hauv cov neeg mob laus thiab cov mob hlwb, kev tsis sib haum ntawm cov kev sib txuas ntawm lub cev muaj zog tuaj yeem tshwm sim, xws li kev tsis tuaj yeem nyob hauv thaj av rotolitic nyob rau hauv daim ntawv ntawm grimacing (rotolitic dyskinesias), kev hloov mus ncig (choreoathetosis). Qee kis ntawm kev hais lus tsis meej, hnov ​​qhov tsis meej, mob lub cev tsis muaj zog, mob hlab ntsha hlwb (leeg leeg mob leeg), thiab ua rau pom nqig tuag tes tuag taw (paresis) thiab saj pom kev tsis meej.

Feem ntau ntawm cov tshwm sim no ploj ntawm lawv tus kheej tom qab 8-14 hnub lossis tom qab txo qis cov tshuaj ib ntus. Yog li ntawd, yog tias ua tau, finlepsin 200 retard yog dosed kom zoo, pib kho nrog cov koob tshuaj qis, tom qab ntawd maj mam nce ntxiv.

Ob lub qhov muag

Muaj qee kis, muaj kev cuam tshuam ntawm kev sib txuas ntawm lub qhov muag (qhov muag tsis pom kev), qee zaum muaj kev cuam tshuam txog qhov muag pom (cuam tshuam hauv kev pab ntawm lub qhov muag, ob lub zeem muag, qhov pom kev tsis pom kev). Cov xwm txheej ntawm clouding ntawm lub lens tau raug tshaj tawm.

Hauv cov neeg mob uas muaj mob txha cajqwm, nws yog qhov yuav tsum tau ntsuas cov leeg ntawm lub plab.

Propulsion system

Hauv cov kis mob sib cais, qhov mob tau pom nyob hauv cov pob qij txha thiab cov leeg (mob pob qij txha, myalgia), nrog rau cov leeg txhaws. Cov tshwm sim no ploj tom qab kev tshem tawm ntawm cov tshuaj.

Daim tawv nqaij thiab qog ua pa

Cov mob uas muaj kev tsis haum ntawm daim tawv nqaij muaj nrog lossis tsis kub taub hau tau tshaj tawm, xws li tsis tshua muaj lossis muaj ntau qhov mob ua ke mob urticaria (urticaria), khaus, qee zaum muaj phaj loj lossis tawv nqaij tawv nqaij tawv (exfoliative dermatitis, erythroderma), necrosis ntawm thaj chaw ntawm daim tawv nqaij nrog blistering (syndrome) Lyell), kev tawm pob txha (photosensitization), liab ntawm daim tawv nqaij nrog cov pob txuv polymorphic nyob rau hauv daim ntawv ntawm cov pob thiab tsim cov ntshav, nrog hemorrhages (exudative erythema multiforme, erythema nodosum, Stevens syndrome Johnson), petechial hemorrhages nyob rau hauv daim tawv nqaij, thiab mauj lupus erythematosus (lupus erythematosus disseminated).

Hauv cov chaw tsis muaj neeg lossis tsis tshua muaj, cov plaub hau ploj (alopecia) thiab tawm hws (diaphoresis) tau sau tseg.

Circulatory thiab lymphatic system

Hauv kev sib txuas nrog cov tshuaj tiv thaiv kev tsis haum siab hauv kev kho tus mob finlepsin 200 retard, ntxiv rau, kev cuam tshuam cov duab ntshav hauv qab no yuav tshwm sim: tsis tshua pom lossis ntau zaus nce (leukocytosis, eosinophilia) lossis txo qis (leukopenia) hauv cov leukocytes lossis platelets (thrombocytopenia) hauv ntshav nruab nrog. Raws li cov ntaub ntawv, ib daim ntawv dhau los ua leukopenia feem ntau pom tshwm sim (hloov mus li ntawm 10% ntawm cov neeg mob, thiab pheej mob siab hauv 2% ntawm cov neeg mob).

Tshaj tawm ntawm cov kis mob sib kis ntawm cov ntshav, qee zaum txawm tias muaj kev phom sij txog lub neej, xws li agranulocytosis, aplastic anemia, nrog rau lwm yam kev mob ntshav tsis txaus (hemolytic, megaloblastic), nrog rau kev nce rau tus txha caj qaum thiab cov qog ntshav.

Nrog cov tsos ntawm leukopenia (feem ntau neutropenia), thrombocytopenia, ua pob ua xua ntawm daim tawv nqaij (exanthema) thiab kub taub hau finlepsin 200 retards tau muab tso tseg.

Kev kho mob txoj hnyuv

Qee zaum yuav tsis qab los noj mov, qhov ncauj qhuav, xeev siab thiab ntuav, raws plab los yog cem quav. Cais tawm los ntawm kev mob plab thiab mob ntawm lub caj pas ntawm txoj hlab pas oropharynx (stomatitis, gingivitis, glossitis) tau raug tshaj tawm. Cov tshwm sim no dhau los ntawm lawv tus kheej tom qab 8-14 hnub ntawm kev kho mob lossis tom qab txo qis ib ntus ntawm cov koob tshuaj. Lawv tuaj yeem zam tau los ntawm thawj lub sijhawm teem sijhawm qis ntawm cov tshuaj nrog lawv nce zuj zus.

Muaj cov lus qhia hauv cov ntawv nyeem uas carbamazepine tuaj yeem qee zaum ua rau mob hlab ntsha hlwb (kab mob pancreatitis).

Mob siab thiab tsib bile

Qee zaum cov kev hloov pauv ntawm cov ntsuas ntawm lub siab ua haujlwm raug tshawb pom, nyob rau qee qhov muaj mob daj ntseg yuav tshwm sim; muaj qee yam mob, muaj ntau hom kab mob siab (cholestatic, hepatocellular, granulomatous, sib xyaw) tshwm sim.

Ob qho xwm txheej ntawm tus mob sib kis tsis tau muaj tau piav qhia.

Hormonal, dej thiab ntsev metabolism hauv

Cais tawm ntawm tus neeg mob lub mis o hauv cov txiv neej (gynecomastia) thiab nthawv cov mis tawm los ntawm cov qog mammary hauv cov poj niam (galactorrhea) tau raug tshaj tawm.

Finlepsin 200 retard tuaj yeem cuam tshuam cov thyroid ua haujlwm tsis sib haum (triiodothyronine, thyroxine, thyroid-stimulating hormone thiab pub dawb thyroxine), tshwj xeeb tshaj yog thaum ua ke nrog lwm cov tshuaj tiv thaiv antiepileptic.

Vim qhov kev txiav txim ntawm finlepsin 200 retard, uas txo qis kev tso zis ntawm lub cev (cov nyhuv antidiuretic), nyob rau hauv cov xwm txheej tsis tshua muaj, qhov kev txo qis ntawm cov dej qab ntsev (hyponatremia) tuaj yeem pom, nrog ntuav, mob taub hau thiab tsis meej pem.

Cov xwm txheej cais ntawm cov tsos ntawm edema thiab nce hauv lub cev qhov hnyav tau pom. Finlepsin 200 Retard yuav qis cov calcium ntau ntau. Hauv cov kis ua mob, qhov no ua rau cov pob txha mos (osteomalacia).

Lub plab ua pa

Cov teeb meem sib cais ntawm cov tshuaj tiv thaiv ntawm cov neeg mob ntsws ntau ntxiv rau cov tshuaj, nrog kub taub hau, ua pa luv (mob ua pa), mob ntsws thiab mob ntsws ntsig, tau piav.

Tub sab caj pa

Tsis tshua muaj qhov ua rau lub raum khiav tsis zoo, qhia los ntawm kev muaj protein ntau hauv cov zis (proteinuria), cov ntshav hauv cov zis (hematuria), tsis tuaj yeem tso zis (oliguria), nyob rau qee qhov tsis tshua pom muaj tshwm sim lub raum tsis ua haujlwm. Tej zaum cov kev tsis zoo no yog vim muaj qhov ua tib zoo siv tshuaj tiv thaiv cov tshuaj. Qee zaum dysuria, pollakiuria thiab tso zis tawm tsam.

Tsis tas li ntawd, muaj cov neeg paub txog kev sib daj sib deev, xws li tsis muaj zog thiab tsis muaj siab rau kev sib deev.

Kev kho plawv

Muaj qee qhov tsis tshua muaj lossis cais tus neeg mob, feem ntau yog rau cov neeg laus lossis cov neeg mob uas paub mob plawv tsis ua haujlwm, txo lub plawv dhia (bradycardia), lub plawv dhia tsis ua hauj lwm, thiab kev mob ntshav siab hauv lub plawv yuav tshwm sim.

Tsis tshua muaj kev ua txhaum ntawm qhov tsis txaus siab nyob rau hauv lub siab (atrioventricular block), hauv cov teeb meem sib cais nrog kev tsaus muag. Ntxiv mus, hauv qee kis, cov ntshav siab poob qis lossis nce siab. Kev poob hauv cov ntshav siab feem ntau tshwm sim nrog kev siv cov tshuaj hauv qhov siab.

Ib qho ntxiv, vasculitis, thrombophlebitis, thiab thromboembolism tau pom.

Kev ua haujlwm tsis haum siab

Qaug rau cov tshuaj tiv thaiv tsis haum tshuaj tsis tshua tau tshwm sim, tshwm sim ua npaws, ua pob rau ntawm daim tawv nqaij, vascular o, mob rau cov qog ntshav, mob pob qij txha, hloov cov ntshav dawb hauv cov ntshav nruab nrog ntshav, ua rau lub siab thiab tus po, thiab qhov hloov pauv lub siab ua haujlwm kuaj uas tuaj yeem tshwm sim sib txawv kev sib xyaw ua ke, thiab tseem koom nrog lwm cov plab hnyuv siab raum hauv cov txheej txheem, xws li lub ntsws, ob lub raum, txiav thiab myocardium.

Hauv cov kis mob cais, kev tiv thaiv kab mob dav dav thiab cov mob ua paug rau cov hlab ntshav nrog myoclonus thiab eosinophilia tau pom.

Yog tias koj pom cov kev mob tshwm sim uas tsis hais hauv cov lus ceeb toom no, thov qhia rau koj tus kws kho mob lossis kws muag tshuaj txog qhov no.

Dab tsi ntsuas yuav tsum tau ua nrog kev phiv

Yog tias koj pom cov kev mob tshwm sim saum toj no, tom qab ntawv ceeb toom rau koj tus kws kho mob tam sim ntawd uas yuav txiav txim siab lawv qhov mob hnyav thiab siv kev ntsuas los tawm tsam lawv (saib tshooj "Kev Ceeb Toom rau kev siv"). Tshwj xeeb tshaj yog thaum muaj kub taub hau, mob caj pas, ua xua ntawm daim tawv nqaij ua pob ua xua nrog ua mob rau cov qog ntshav thiab / lossis zoo li mob khaub thuas zoo li cov tsos mob thaum kho nrog finlepsin 200 retards, koj yuav tsum tam sim ntawd sab laj nrog kws kho mob thiab soj ntsuam daim duab ntshav.

Nrog rau kev txhim kho ntawm kev fab tshuaj tsis haum, finlepsin 200 retard yog tam sim ntawd tso tseg.

Thaum qee yam kev hloov pauv hauv cov ntshav duab tshwm sim (leukopenia, ntau zaus neutropenia, thrombocytopenia), kev tawm tsam ntawm daim tawv nqaij ua xua (exanthema) thiab kub taub hau finlepsin 200 retards raug tso tseg.

Yog tias muaj cov cim qhia ntawm daim siab ua rau lub siab puas lossis ua haujlwm tsis zoo, xws li lub siab tsis txaus, tsis qab los noj mov, xeev siab, daj tawv nqaij lossis ua kom lub siab nce siab, tam sim ntawd sab laj nrog kws kho mob.

Hnub siv tshuaj yaj yeeb

3 xyoos
Lub txee lub neej ntawm cov ntsiav tshuaj retard yog qhia rau ntawm cov ntawv ci ntawm lub ntsej muag blister ntim thiab rau ntawm lub thawv ntawv thawv.
Tom qab lub sijhawm tau teev tseg, tsis txhob siv ntau dua cov ntsiav tshuaj rov qab ntawm pob ntawv no.

Tshuaj muab tshuaj cia kom ncav tsis cuag cov menyuam!

Finlepsin 200 retard los txog hauv cov menyuam yaus muaj kev nyab xeeb ntim nrog cov ntawv ci tuab dua. Nyob rau hauv rooj plaub nws yog qhov nyuaj rau koj los nyem lub ntsiav tshuaj retard, tom qab ntawd ua ntej koj ua qhov no, peb qhia koj kom me ntsis incise ntawv ci los npog.

Cia rau cov neeg mob

Cov tshuaj no yog muab cia rau hauv ib qho kev mob ib txwm.

Tso Tawm Cov Ntawv

Finlepsin 200 retard muaj nyob rau hauv pob ntawm 50, 100, thiab 200 retard ntsiav tshuaj.

Cev xeeb tub thiab lactation

Thaum twg los xij tau, Finlepsin ard retard raug tso cai rau cov poj niam ntawm kev ua me nyuam lub hnub nyoog xws li tshuaj tua kab mob, hauv kev siv tshuaj tsawg kawg nkaus, qhov ntsuas mob tsis xwm yeem ntawm cov me nyuam yug tshiab los ntawm cov niam uas siv cov tshuaj tiv thaiv kev tiv thaiv kab mob siab dua rau kev kho tus mob monotherapy.

Thaum cev xeeb tub tshwm sim, nws yog ib qho tsim nyog los sib piv cov txiaj ntsig ntawm kev kho thiab qhov muaj peev xwm ua tau tshwm sim, tshwj xeeb tshaj yog nyob rau thawj peb lub hlis thaum cev xeeb tub.

Nws raug paub tias cov menyuam yaus ntawm leej niam uas muaj kev txom nyem los ntawm kev mob vwm tuaj yog thawj coj rau txoj kev loj hlob ntawm intrauterine, suav nrog kev ua tsis tiav. Finlepsin ® retard muaj peev xwm ua kom muaj kev pheej hmoo ntawm cov teeb meem no. Muaj cov ntaub ntawv sib cais los ntawm tus neeg mob ntawm cov kab mob ua tsis taus pa thiab tsis meej, nrog rau tsis txiav cov pob txha caj qaum. (spina bifida)Cov. Cov tshuaj antiepileptic nce folic acid deficiency, uas feem ntau pom thaum cev xeeb tub, uas tuaj yeem ua rau muaj qhov tsis zoo ntawm kev yug menyuam hauv menyuam yaus, yog li noj folic acid pom zoo ua ntej npaj lub sijhawm cev xeeb tub thiab thaum cev xeeb tub. Txhawm rau tiv thaiv hemorrhagic muaj teeb meem hauv cov menyuam mos, nws raug pom zoo tias cov poj niam nyob rau lub lim tiam dhau los ntawm cev xeeb tub, nrog rau cov menyuam yug menyuam, yuav tsum tau muaj tshuaj vitamin K.

Carbamazepine hla mus rau niam mis, yog li cov txiaj ntsig thiab qhov tsis xav tau ntawm kev pub niam mis yuav tsum muab piv nrog kev kho mob txuas ntxiv. Nrog kev pub mis niam txuas ntxiv thaum noj cov tshuaj, koj yuav tsum tsim kev soj ntsuam rau tus menyuam hauv kev txuas nrog qhov muaj feem ua rau muaj kev phiv tshuaj (piv txwv, tsaug zog heev, kev tsis haum ntawm daim tawv nqaij).

Chaw tsim tshuaj paus

Teva Kev Ua Haujlwm Poland Sp. z oo, st. Mogilska 80, 31-564 Krakow, Poland.

Lub npe ntawm cov neeg muaj kev cai lij choj nyob rau hauv uas lawv lub npe pov thawj rau kev tso npe tawm. Teva Kev Lag Luam Lag Luam Ltd., Ixayees.

Kev thov cov neeg tau txais kev pab yuav tsum tau xa mus rau qhov chaw nyob: 115054, Moscow, ul. Tag nrho, 35.

Xov tooj: (495) 644-22-34, fax: (495) 644-22-35 / 36.

Cov lus qhia rau kev siv Finlepsin retard

Raws li cov lus qhia, qhov ua tau zoo ntawm cov tshuaj tsis muaj feem xyuam nrog kev noj zaub mov, yog li koj tuaj yeem haus nws lub sijhawm twg los tau. Rau kev kho mob ntawm kev mob vwm, Finlepsin yog siv los kho tus mob monotherapy, tsis txuas nrog lwm yam tshuaj. Cov koob tshuaj tau ua tib zoo xam rau cov hnub nyoog sib txawv, pib nrog qhov tsawg kawg nkaus thiab nce ntxiv zuj zus. Raws li cov lus qhia rau cov neeg laus, cov tshuaj txhua hnub hauv qab no yog siv:

• thaum pib - 200-400 mg,
• kev kho mob lossis kev txhawb nqa - 800-1200 mg,
• qhov siab tshaj plaws yog 1600-2000 mg.

Tus nqi ntawm carbamazepine no yog rau txhua tus neeg, nws muab faib ua 3-4 koob. Yog hais tias tus neeg mob tsis txhob txwm poob ntsiav tshuaj vim li cas los xij, tom qab ntawd koj yuav tsum tsis txhob haus ob zaug ib zaug kom tsis txhob noj ntau dhau. Hauv kev kho cov menyuam yaus, cov tshuaj txhua hnub nyob ntawm lub hnub nyoog, maj mam nce ntxiv los ntawm 100 mg kom txog thaum cov txiaj ntsig xav tau:

• 1-5 xyoos - 100-200 txog 400 mg,
• 6-10 xyoo - 200-300 txog 600 mg,
• 11-15 xyoo - 300-400 txog 1000 mg.

Lub sijhawm ua haujlwm ntawm Finlepsin yuav tsum tswj hwm los ntawm tus kws kho mob, tsom mus rau kev nyob zoo ntawm tus neeg mob. Hauv qee kis, nws siv ob peb xyoos rau kev tawm tsam nres. Qhov ntau npaum li cas yog txo tom qab tau txais kev kho mob zoo thiab qhov tsis tuaj ntawm qaug dabpeg rau 2-3 xyoos. Txoj kev zoo tshaj plaws los ntsuas qhov kev ua tau zoo ntawm Finlepsin kev kho yog kom muaj ib qho electroencephalogram ntawm lub paj hlwb.

Finlepsin Retard Nqe

Tom qab ntsib tus kws kho mob, koj yuav tsum tau yuav ib daim ntawv yooj yim ntawm cov tshuaj thiab pib noj nws. Qhov sib txawv hauv nqe rau Finlepsin hauv St. Petersburg thiab Moscow yog nyob ntawm cov naj npawb ntawm cov ntsiav tshuaj, ntim, muab ntau npaum li cas.

Finlepsin-200, 50 pcs.

Finlepsin-400, 30 pcs.

Finlepsin-400, 50 pcs.

Hauv Lavxias, kev muag ntawm Finlepsin retard yog nqa los ntawm Polish chaw tsim tshuaj paus TEVA. Thaum cov tshuaj tsis haum rau tus neeg mob, tus kws kho mob tuaj yeem xaiv ib qho ntawm Finlepsin's analogues. Cov tshuaj muaj tshuaj zoo sib xws, muaj tib lub zog. Cov lus piv txwv, tsis zoo li lub qub, yog pheej yig, tab sis muaj lwm cov kev mob tshwm sim, yog li nws tsis pom zoo hloov Finlepsin ntawm koj tus kheej.

Daim ntawv ntawm cov tshuaj antiepileptic muaj xws li:

Regina, hnub nyoog 53 xyoos. Kuv haus Finlepsin rau 2 hlis, thaum tus kws kho mob sau nws rau kuv tom qab o ntawm trigeminal hlab ntsha. Kuv tau ceeb toom tias cov tshuaj muaj ntau qhov tshwm sim, yog li kuv pib noj ib nrab ntsiav tshuaj thaum xub thawj. Nws tseem tsis tuaj yeem zam qhov kev ua tsis zoo kiag li - thaum sawv ntxov kuv tau tsaus muag me ntsis, tab sis lwm yam Finlepsin tau pab kuv.

Julia, hnub nyoog 35 xyoo. Nrog kev pab los ntawm Finlepsin no, Kuv kho tau tus mob vwm epilepsy rau menyuam yaus. Cov ntsiav tshuaj tau diluted hauv phoov. Kuv yuav tsum tau tso nrog kev tawm tsam ntawm kev qaug zog thiab xeev siab me ntsis, tab sis rau 1 xyoo ntawm kev nkag mus rau hauv kev saib xyuas ntawm tus kws tshaj lij, peb tau tswj kom tsis txhob qaug dab peg. Peb tau sim hloov mus rau cov tshuaj uas zoo sib xws, uas sib txawv hauv tus nqi, tab sis nws tsis haum.

Eugene, 47 xyoo lawm Siv Finlepsin rau kev nyuaj siab rau lub tswv yim ntawm tus kws kho mob hlwb. Kuv xaj kom yuav khoom hauv khw online nrog xa khoom xa ntawv. Ntawm tus nqi luv, nws muab tawm tsis kim. Tus kws kho mob tau ceeb toom kuv kom tsis txhob muab Finlepsin thiab haus cawv, txwv tsis pub cov kev mob tshwm sim yuav phem dua li cov lus piav qhia hauv cov tshuaj. Kuv tsis pom zoo kom haus cov tshuaj yam tsis muaj ntawv kho mob.