Berlition 600 ntsiav tshuaj: cov lus qhia rau kev siv

cov tshuaj nquag - thioctic acid 600 mg

tus zam: rog ua kom rog, nruab nrab saw triglycerides.

plhaub: 70% sorbitol daws, tsis-crystallizing (nyob rau hauv cov ntsiab lus ntawm anhydrous yam), 85% glycerin (nyob rau hauv cov ntaub ntawv ntawm anhydrous tshuaj), gelatin, titanium dioxide (E 171), carmine kua roj vanish (E 120).

Cov chaw muag tshuaj

Hauv tib neeg, thioctic acid sai sai tom qab kev tswj hwm qhov ncauj. Vim lub suab tshaj tawm ntawm thawj qhov kev nkag los ntawm lub siab, qhov tsis zoo ntawm bioavailability (hauv kev sib piv nrog kev tswj hwm iv) ntawm thioctic acid noj hauv yog kwv yees. 20% Vim tias kev faib tawm sai heev hauv cov ntaub so ntswg, ib nrab-lub neej ntawm thioctic acid los ntawm ntshav hauv tib neeg yog kwv yees li 25 feeb.

Qhov txheeb ze bioavailability ntawm thioctic acid thaum noj ntawm qhov ncauj rau hauv cov ntaub ntawv tsuas yog ntau dua 60% piv rau cov kev daws qhov ncauj. Qhov siab tshaj plaws ntshav cov ntsiab lus ntawm kwv yees li. 4 mcg / ml, ua tiav tom qab kwv yees. 0.5 h tom qab kev tswj hwm qhov ncauj ntawm 600 mg ntawm thioctic acid.

Hauv kev sim rau cov tsiaj (nas, dev), siv daim ntawv lo rau xov tooj cua, nws muaj peev xwm txheeb xyuas feem ntau cov neeg lub raum ua tau zoo tshaj (80-90%), uas yog, nyob rau hauv daim ntawv ntawm metabolites. Hauv tib neeg, tsuas yog cov tsis tseem ceeb ntawm cov tshuaj uas tso tsis tau lawm kuj muaj nyob hauv zis. Biotransformation feem ntau tshwm sim los ntawm oxidative shortening ntawm sab saw (beta oxidation) thiab / lossis los ntawm S-methylation ntawm cov thiols sib nug.

Thioctic acid reacts hauv vitro nrog cov hlau ion ua haujlwm (piv txwv li cisplatin). Thioctic acid nrog piam thaj molecules nkag mus rau hauv sparingly soluble complex compound.

Cov Tshuaj Hauv Tshuaj

Thioctic acid yog vitamin-zoo li tab sis endogenous tshuaj uas ua raws li coenzyme hauv oxidative decarboxylation ntawm alpha-keto acids. Hyperglycemia tshwm sim los ntawm cov ntshav qab zib mellitus ua rau kom muaj kev tso ntshav ntawm cov kua nplaum ntawm cov roj ntsha ntawm cov roj ntsha thiab tsim cov khoom lag luam kawg ntawm kev txhim kho glycosylation ("Advanced Glycosylation End Products"). Tus txheej txheem no ua rau muaj kev txo qis rau cov ntshav endoneural thiab rau endoneural hypoxia / ischemia, uas cuam tshuam nrog nce ntau ntxiv ntawm cov pa oxygen dawb uas ua rau puas cov leeg. Hauv cov hlab ntsha peripheral, tso tawm cov antioxidants, xws li glutathione, kuj tau pom. Kev tshawb nrhiav pom tias thioctic acid koom nrog cov txheej txheem biochemical, txo cov kev tsim cov khoom kawg glycosylation, txhim kho endoneural ntshav txaus, thiab nce qib physiological ntawm glutathione antioxidant. Nws kuj ua raws li lub zog tawm tsam cov oxygen dawb radicals hauv cov leeg ntshav ntsha cuam tshuam los ntawm ntshav qab zib. Cov teebmeem no tau pom thaum kev sim qhia tau hais tias nrog kev pab ntawm thioctic acid, kev ua haujlwm ntawm cov hlab ntsha peripheral tuaj yeem hloov kho. Qhov no siv rau qhov mob rhiab heev hauv kev mob ntshav qab zib polyneuropathy, uas tuaj yeem pom tias yog dysesthesia thiab paresthesia (piv txwv li, hlawv, mob, loog lossis nkag). Cov kev tshawb fawb soj ntsuam qhia txog cov txiaj ntsig zoo ntawm thioctic acid nyob rau hauv kev kho mob ntawm kev mob ntshav qab zib polyneuropathy, nrog rau cov kev paub zoo xws li mob kub hnyiab, mob caj dab, mob lub cev thiab mob.

Pharmacodynamics thiab pharmacokinetics

Berlition suav nrog ua cov khoom xyaw dhia thioctic kua qaub (alpha lipoic kua qaub) nyob rau hauv daim ntawv ntawm ethylene diamine ntsev, uas yog cov tshuaj tiv thaiv kab mob endogenous uas khi rau cov dawb radicals nrog coenzyme ntawm alpha-keto acid decarboxylation cov txheej txheem.

Kev kho Berlition txo cov ntshav muaj ntshav ntau ntau. piam thaj thiab nce siab glycogentsis muaj zog insulin kuj, txhawb kev noj cov roj cholesterol, tswj cov lipid thiab carbohydrate metabolism. Thioctic acidVim tias nws cov haujlwm ua antioxidant los tiv thaiv, nws tiv thaiv lub hlwb ntawm tib neeg lub cev los ntawm kev puas tsuaj los ntawm lawv cov khoom lwj.

Hauv cov neeg mob mob ntshav qab zib thioctic acid txo qhov kev tso tawm ntawm cov khoom lag luam kawg glycation protein hauv cov hlab ntsha hlwb, nce microcirculation thiab txhim kho endoneural ntshav txaus, nce physiological concentration glutathione antioxidantCov. Vim nws lub peev xwm los txo cov plasma cov ntsiab lus, nws cuam tshuam rau lwm txoj hauv kev ntawm nws cov metabolism.

Thioctic acid txo cov kev txuam nrog pathological polyol metabolites, yog li pab txhawb kom txo qis kev o ntawm cov leeg. Normalizes conduction ntawm paj impulses thiab lub zog metabolism. Kev koom nrog cov rog hauv lub cev, ua kom muaj biosynthesis ntau dua phospholipidsRaws li qhov tshwm sim, qhov kev puas tsuaj ntawm lub qog ntawm tes tau kho dua tshiab. Tshem Tawm lom nyhuv cov khoom lag luam metabolic dej cawv (pyruvic acid, acetaldehyde), txo qhov tshaj tawm ntawm cov pa tawm dawb radical lwg me me, txo kom tsawg ischemia thiab endoneural hypoxiakev txo cov tsos mob polyneuropathyhauv daim ntawv paresthesiakev hnov ​​khaus, khaus thiab mob hauv nqua.

Raws li qhov tau hais dhau los, thioctic acid yog tus yam ntxwv ntawm nws lub cev hypoglycemic, neurotrophic thiab antioxidant, nrog rau kev txhim kho lipid metabolism ntawv. Siv hauv kev npaj cov khoom xyaw nquag hauv daim ntawv ethylene diamine ntsev tso cai rau koj kom txo qhov hnyav ntawm qhov tshwm sim tsis zoo kev cuam tshuam ntawm thioctic acid.

Thaum noj ntawm qhov ncauj, thioctic acid yog nrawm thiab ua kom tiav los ntawm cov hnyuv (zaub mov noj thaum uas tig mus txo qis kev nqus qee yam). TCmax hauv cov ntshav txawv ntawm 25-60 feeb (nrog kev tswj hwm 10-11 feeb). Ntshav Cmax yog 25-38 mcg / ml. Bioavailability ntawm kwv yees li 30%, Vd kwv yees li 450 ml / kg, AUC ntawm kwv yees li 5 μg / h / ml.

Thioctic acid yog qhov ua rau lub siab "dhau thawj" los ntawm daim siab. Kev rho tawm cov khoom lag luam metabolic ua tau los ntawm cov txheej txheem kev sib xyaw thiab sab saw hlau oxidationCov. Kev nqhis dej hauv daim ntawv ntawm cov khoom noj siv hluav taws xob yog 80-90% nqa tawm los ntawm lub raum. T1 / 2 yuav siv li ntawm 25 feeb. Kev tshem ntshav tag nrho yog 10-15 ml / min / kg.

Cov Yuav Tsum Muaj

Berlition yog contraindicated rau cov neeg mob hnub nyoog qis dua 18 xyoo, cov neeg mob nrog tus kheej hypersensitivity mus rau lub active (thioctic acid) los yog ib yam ntawm cov khoom xyaw siv nyob rau hauv kev kho mob ntawm daim ntawv tshuaj ntawm cov tshuaj, nrog rau lactating thiab cov poj niam cev xeeb tub.

Berlition 300 ntsiav tshuaj, vim yog muaj nyob hauv daim ntawv no ntau npaum lactosecontraindicated nyob rau hauv cov neeg mob uas muaj keeb qab zib intolerance.

Rau txhua daim ntawv qhia ntawm cov tshuaj

• ua txhaum / pauv hloov hauv saj,
• txo hauv ntshav cov ntsiab luspiam thaj (vim kev txhim kho ntawm nws nqus tau),
• symptomatology ntshav qogsuav nrog qhov tsis pom kev, kiv taub hau, hyperhidrosis, mob taub hau,
• kev tsis haumsuav nrog tawv nqaij ua pob/khausurticaria tawm pob (urticaria), anaphylactic poob siab (nyob rau hauv tus neeg mob cais).

Txuas ntxiv rau cov niam txiv cov ntawv sau ntawm cov tshuaj

• daim ntawv pov thawj,
• hlawv nyob rau thaj tsam ntawm kev txhaj tshuaj,
• cramps,
• thrombocytopathy,
• purpura
• txog siav thiab nce siab intracranial (sau tseg nyob rau qhov xwmtxheej iv tswjfwm thiab dhau nrawm).

Berlition, cov lus qhia rau kev siv (Txoj kev thiab ntau npaum li cas)

Cov lus qhia ua haujlwm rau kev siv Berlition 300 yog qhov zoo ib yam rau cov lus qhia rau kev siv Berlition 600 rau txhua daim ntawv tshuaj ntawm cov tshuaj no (txhaj tshuaj, tshuaj tsiav tshuaj, ntsiav tshuaj).

Cov tshuaj Berlition npaj rau kev npaj ntawm infusions yog pib sau tseg nyob rau hauv kev noj tshuaj txhua hnub ntawm 300-600 mg, uas tau muab tshuaj rau txhua hnub hauv qhov dej nrog tsawg kawg 30 feeb, rau 2-4 lub lis piam. Tam sim ntawd ua ntej Txoj kev lis ntshav, ib qho tshuaj tov tau npaj los ntawm kev sib xyaw cov ntsiab lus ntawm 1 ampoule ntawm 300 mg (12 ml) lossis 600 mg (24 ml) nrog 250 ml Sodium Chloride Txhaj Tshuaj (0,9%).

Hauv kev sib txuas nrog kev sib txuas ntawm qhov kev daws teeb meem, nws yuav tsum muaj kev tiv thaiv los ntawm kev sib chwv pom, piv txwv li, qhwv nrog txhuas ntawv ci. Hauv daim foos no, txoj kev daws teeb meem tuaj yeem khaws nws cov khoom li ntawm 6 teev.

Tom qab 2-4 lub lis piam ntawm kev kho nrog kev siv cov infusions, lawv hloov mus rau kev kho mob nrog kev siv cov tshuaj ntawm qhov ncauj ntawm cov tshuaj. Berlition tsiav tshuaj los yog ntsiav tshuaj tau sau rau hauv cov tshuaj txij nkawm txhua hnub ntawm 300-600 mg thiab tau noj ntawm lub plab tas nrho li ntawm ib nrab ib teev ua ntej noj mov, haus dej 100-200 ml.

Lub sijhawm ntawm kev lis ntshav thiab kho mob hauv qhov ncauj, nrog rau qhov ua tau ntawm lawv cov kev coj ua tas mus li, yog txiav txim siab los ntawm tus kws kho mob mus koom ib tus zuj zus.

Noj ntau dhau

Cov tsos mob tsis zoo ntawm kev siv ntau tshaj thioctic kua qaub manifests nws tus kheej xeev siab dov rau hauv ntuav thiab mob taub hau.

Hauv cov xwm txheej loj, nws yuav pom qhov muag plooj lossis kev ntxhov siab psychomotordav dav cramps, ntshav qog (ua ntej coma), mob cov kua qaub-acid hnyav nrog nrog lactic acidosisntse cov leeg necrosis pob txha ntau yam hauv nruab nrog cev tsis ua haujlwm, hemolysis, DIC, kev txwv tsis pub ua pob txha ua ub no.

Yog tias koj xav tias muaj tshuaj lom thioctic acid (piv txwv li, thaum noj ntau dua 80 mg ntawm tus neeg sawv cev rau ib phaus 1 phaus), nws raug nquahu kom tus neeg mob tau mus pw hauv tsev kho mob tam sim ntawd thiab pib siv feem ntau lees txais kev ntsuas los tiv thaiv kev raug mob lom (lub plab zom mov tutxais tos sorbents lwm yam). Yav tom ntej, kev kho cov tsos mob yog qhia.

Kev Kho Mob lactic acidosis, kev qaug dab peg thiab lwm yam kev pheej hmoo uas yuav txo tau txoj sia ntawm tus neeg mob yuav tsum tau muaj nyob hauv pawg ntseeg kev saib xyuas hnyavCov. Tshwj xeeb tshuaj tiv thaiv kab mob tsis qhia npe. Hemoperfusion, hemodialysis thiab lwm txoj kev lim dej yuam tsis muaj txiaj ntsig.

Tso tawm daim ntawv thiab muaj pes tsawg leeg

Daim ntawv tshuaj lub cev ntawm Berlition 600 yog mloog zoo rau kev npaj ntawm ib qho kev daws teeb meem: cov kua ntshiab, ntsuab daj hauv 24 ml hauv tsaus iav ampoules (25 ml) nrog rau cov kab tawg (npav xim dawb) thiab ntsuab-daj-ntsuab kab txaij, txhua 5 pcs. hauv hnab yas pallet, hauv duab los qhia ib pob 1 pallet.

1 ampoule muaj:

• cov tshuaj nquag: thioctic acid - 0.6 g,
• ntu ntu: ethylenediamine, dej rau txhaj.

Cov Tshuaj Pharmacokinetics

Nrog kev tswj hwm tshuaj ntawm cov tshuaj, qhov siab tshaj plaws ntawm thioctic acid hauv cov ntshav tau txog tom qab 30 feeb. C tus nqi_max kwv yees li 20 μg / ml. Metabolized los ntawm oxidation ntawm lub saw sab, thiab txuas nrog. V_d (ntim khoom faib) yog 450 ml / kg. Thioctic acid thiab nws cov khoom ua rau lub cev ua haujlwm tawm los ntawm lub raum (txoj kev tseem ceeb ntawm kev nthuav tawm). Qhov kev tshem tawm ib nrab-lub neej yog li 25 feeb.

Berlition 600: cov lus qhia rau kev siv (ntau npaum thiab hom)

Berlition 600 yog muab tshuaj rau hauv daim ntawv ntawm txoj kev daws teeb meem.

Thaum pib ntawm txoj kev kho, cov tshuaj yog tawm hauv ib koob ntawm 600 mg ib hnub (1 ampoule ntawm mloog zoo). Raws li txoj cai, chav kawm ntawm kev kho mob yog 2-4 lub lim piam, tom qab kev kho kev kho mob nrog thioctic acid nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm ib koob ntawm 300-600 mg ib hnub yog nqa tawm. Lub sijhawm nyob ntev ntawm kev kho, nrog rau qhov yuav tsum tau rov kawm, yog txiav txim los ntawm tus kws kho mob.

Los npaj ib qho kev daws teeb meem rau Txoj kev lis ntshav, cov ntsiab lus ntawm ib qho ampoule yog diluted hauv 250 ml ntawm physiological saline. Cov tshuaj tiav tiav tau muab tswj hwm ntawm qhov quav, maj mam (tsawg kawg 30 feeb). Thioctic acid yog qhov muag daws, yog li cov tshuaj yuav tsum tsis txhob txhaws ua ntej. Qhov npaj daws tau yuav tsum muaj kev tiv thaiv los ntawm kis los ntawm pom.

Sab sij huam

• cov metabolism: tsis tshua muaj - kev txo qis ntshav muaj ntshav qab zib, qee zaum nce rau lub cev tsis muaj ntshav qab zib (tshwm sim los ntawm cov tsos mob xws li kiv taub hau, mob taub hau, qhov muag plooj thiab tawm hws ntau),
• lub hauv nruab nrab thiab ntu ntu hauv lub paj hlwb: tsis tshua muaj tshwm sim - kev hloov pauv ntawm lub cev, lub ntsej muag binocular tsis pom kev, cuam tshuam,
• hematopoietic system: muaj tsawg kawg - thrombophlebitis, hemorrhagic pob, nce los ntshav vim muaj cov plahaum tsis muaj nuj nqi,
• kev ua xua: tsis tshua muaj tshwm sim - urticaria, khaus, tawm pob ntawm daim tawv nqaij, raug mob sib cais - mob anaphylactic,
• cov kev hloov hauv zos: tsis tshua muaj heev - kev hnov ​​mob ntawm qhov chaw txhaj tshuaj ntawm txoj kev daws teeb meem,
• Lwm yam: ua pa nyuaj thiab qhov zoo nyob hauv lub taub hau (tshwm sim nrog kev tswj hwm ntawm cov tshuaj sai thiab dhau ntawm lawv tus kheej).

Cov lus qhia tshwj xeeb

Cov neeg mob ntshav qab zib noj cov tshuaj hypoglycemic tshwj xeeb yuav tsum kuaj xyuas lawv cov ntshav qab zib kom qis (tshwj xeeb thaum pib kho nrog Berlition 600). Qhov no yog qhov tsim nyog rau kev tiv thaiv raws sij hawm ntawm lub xeev hypoglycemic. Rau qee kis, kev kho cov tshuaj insulin lossis cov tshuaj hypoglycemic rau kev tswj hwm ntawm qhov ncauj yuav tsum tau.

Nrog kev tswj hwm ntawm cov leeg, qhov tshuaj tiv thaiv tsis tuaj yeem tshwm sim. Cov tsos mob ntawm daim tawv nqaij khaus, xeev siab, malaise lossis lwm yam cim ntawm kev ua kom tsis haum yog qhov qhia rau sai sai ntawm thioctic acid.

Cov dej cawv txo cov hauj lwm zoo ntawm Berlition 600, yog li thaum lub sijhawm kho koj yuav tsum tso tseg txoj kev haus cawv hauv cov cawv.

Tsuas yog 0.9% sodium chloride daws yuav siv tau los ua cov hnyav rau cov concentrate. Qhov npaj daws yuav tsum tau muab cia rau hauv qhov chaw tsaus, ntxiv rau tiv thaiv los ntawm lub teeb los ntawm txhuas ntawv ci. Lub txee lub neej ntawm kev daws teeb meem tsis pub dhau 6 teev.

Kev cuam tshuam rau kev muaj peev xwm tsav tsheb thiab cov txheej txheem nyuaj

Tsis muaj cov ntaub ntawv hais txog cov nyhuv ntawm Berlition 600 ntawm tus neeg mob lub peev xwm los mloog lossis ceev ceev teb rau qhov xwm txheej, vim tias tsis muaj kev tshawb nrhiav tshwj xeeb. Thaum kho nrog tshuaj, yuav tsum ceev faj thaum ua ib qho haujlwm twg cuam tshuam nrog kev phom sij ntawm lub neej thiab kev noj qab haus huv ntau dua.

Yeeb tshuaj sib cuam tshuam

Berlition 600 muaj peev xwm tsim chelate ntau nrog hlau, magnesium, calcium thiab lwm yam hlau, yog li lawv siv ua ke yuav tsum zam.

Thioctic acid ua rau lub ntsej muag hypoglycemic zoo ntawm cov tshuaj insulin thiab qhov ncauj tshuaj hypoglycemic, thiab kuj txo cov kev kho mob ntawm cisplatin.

Ethanol ho txo ​​cov nyhuv ntawm Berlition 600.

Txhawm rau npaj cov kev daws teeb meem, koj tsis tuaj yeem siv cov kev daws teeb meem ntawm fructose, dextrose, qabzib, Ringer, nrog rau cov kev daws teeb meem uas cuam tshuam nrog cov choj disulfide thiab SH-pawg.

Cov lus sib piv ntawm Berlition 600 yog: Tiolepta, Thioctic acid-Vial, Thiogamma, Thioctacid 600 T, Lipoic acid, Alpha-lipoic acid, Thioctic acid, Lipothioxin, Berlition 300, Thioctacid BV, Espa-Lipon, Octolipen, Lipolic, Lipolion, Tolipion, Tolipion, Tolipion, Tolipion, Tolipion, Tulip, Acolo Cov.

Berlition 600 tshuaj xyuas

Cov tshuaj muaj peev xwm tau txais ntau cov kev ntsuas tau zoo, vim nws tsis yog tsuas yog ua tau zoo, tab sis kuj zoo zam rau los ntawm cov neeg mob. Vim nws cov nyhuv antitoxic, Berlition 600 feem ntau siv rau hauv kev kho dej cawv. Nws kuj tseem pab tau zoo nyob rau hauv kev tiv thaiv thiab kev kho mob ntawm kev mob ntshav qab zib, tau txais txiaj ntsig zoo dua li qee qhov tsis zoo.

Raws li kev txheeb xyuas, Berlition 600 yuav luag tsis muaj qhov tsis muaj qhov tsis xws luag, tsuas yog kev zam ntawm tus nqi siab.

Tsuas tshuaj thiab tswj hwm

Qhov koob tshuaj txhua hnub yog 1 tshuaj ntsiav ntawm Berlition® 600 tsiav tshuaj (sib haum rau 600 mg ntawm thioctic acid), uas tau noj ib zaug, kwv yees li 30 feeb ua ntej noj mov thawj zaug.

Nrog mob paresthesia hnyav, koj tuaj yeem ua ntej nqa kev kho mob infusion nrog thioctic acid.

Menyuam yaus thiab tub ntxhais hluas

Berlition® 600 tsiav tshuaj yuav tsum tsis txhob coj los ntawm cov menyuam yaus thiab cov tub ntxhais hluas

Berlition® 600 tsiav tshuaj yuav tsum noj rau ntawm lub plab khoob, nqos tag nrho thiab haus dej kom ntau. Kev noj ib txhij ua rau lub cev tsis yooj yim. Yog li, rau cov neeg mob uas tus cwj pwm los ntawm kev mob plab ntev ntev, nws yog qhov tshwj xeeb tshaj yog tias cov tshuaj yuav tsum noj li ib nrab teev ua ntej noj tshais.

Txij li nws yog ib hom mob ntev los ntawm tus mob ntshav qab zib polyneuropathy, kev kho mob ntev yuav tsim nyog.

Lub hauv paus ntawm kev kho mob ntshav qab zib polyneuropathy yog txoj kev tswj hwm kev muaj mob ntshav qab zib kom zoo tshaj.

Daim ntawv tso tawm thiab ntim khoom

15 tsiav tshuaj muab tso rau hauv cov hlwv qhov chaw ntim ntawm PVC zaj duab xis (hlua PVDH) thiab txhuas ntawv ci.

1 lossis 2 contour pob ua ke nrog cov lus qhia rau kev siv tshuaj hauv xeev thiab Lavxias lus muab tso rau hauv pob ntawv los qhia.

Khaws ntawm qhov kub thiab txias tsis tshaj 25 ° C.

Khaws tsis ncav cuag ntawm cov menyuam yaus!

Tsis txhob siv tom qab hnub tas sij hawm!

Kev sib txuam

Rau thioctic kua qaub tus yam ntxwv yog nws cuam tshuam nrog kev kho mob nrog, nrog rau ionic hlau ntau ceg (Xws li nrog platinum Cisplatin) Hauv qhov no, kev siv sib xyaw ua ke ntawm Berlition thiab kev npaj hlau tuaj yeem ua rau txo qis kev ua haujlwm ntawm yav tom ntej.

Concurrent tswj hwm ntawm ethanol-muaj cov tshuaj ua rau txo qis hauv kev kho mob ntawm Berlition.

Thioctic acid ua rau lub ntsej muag hypoglycemic tshuaj tiv thaiv qhov ncauj hypoglycemic thiab tshuaj insulinuas tej zaum yuav tsum tau kho kom haum rau lawv cov koob tshuaj.

Berlition rau kev txhaj tshuaj yog tsis sib xws nrog cov tshuaj daws teeb meem siv ua lub hauv paus rau kev npaj ntawm Txoj kev lis ntshav sib xyaw, suav nrog lub nplhaib kev daws teeb meem thiab Dextrosenrog rau cov kev daws teeb meem uas hnov ​​mob nrog cov txuas pob zeb disulfide lossis SH-pawg.

Thioctic acid muaj peev xwm tsim sparingly soluble complex nrog qab suab molecules.

Cov Cai Siv Tshuaj So

Chaw Tsim Tshuaj / Tus Tswv Ntawm Daim Ntawv Tso Npe

BERLIN-HEMI AG (MENARINI GROUP)

Gliniker Cov Nqaij 125

12489 Berlin, Lub Tebchaws Yelemees

Pob Ntawv

Catalent Germany Schorndorf GmbH, Lub Tebchaws Yelemees

Lub chaw nyob ntawm lub koom haum lees txais kev tsis txaus siab los ntawm cov neeg siv khoom ntawm cov khoom lag luam zoo (cov khoom lag luam) hauv thaj chaw ntawm cov koom pheej ntawm Kazakhstan:

Sawv cev ntawm JSC "Berlin-Chemie AG" hauv koom pheej ntawm Kazakhstan

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Berlition lossis Heptral

Hauv kev sib txuas nrog hepatoprotective lub zog ntawm Berlition, ib pawg ntawm cov tshuaj uas muaj qhov rov ua dua nyob rau mob siab, ib tug neeg sawv cev tseem ceeb ntawm uas yog HeptralCov. Ntawm chav kawm, nws yog qhov nyuaj dua kom kos parallels hais txog qhov tshwm sim ntawm ob tus neeg saib xyuas, vim tias lawv tseem koom nrog cov pab pawg sib txawv, suav nrog cov khoom xyaw sib txawv thiab muaj cov yam ntxwv sib txawv ntawm kev ua, txawm li cas los xij, hauv kev kho mob siab pathologies, lawv feem ntau hloov lossis ntxiv los ntawm lwm tus.

Vim tias qhov tsis txaus kawm ntawm kev ua haujlwm ntawm Berlition rau menyuam yaus lub cev, nws qhov kev siv rau hauv cov kabmob yog contraindicated.

Cov lus qhia rau kev siv

Berlition yog hais txog cov kab mob metabolic uas tswj cov metabolism hauv cov rog thiab carbohydrates. Cov tshuaj qaug tshuaj ntawm tshuaj yog thioctic acid. Cov tshuaj yog tsim hauv cov ntsiav tshuaj thiab hauv daim ntawv ntawm mloog zoo rau qhov kev npaj ntawm kev daws rau infusion.

Berlition yog tshuaj rau cov neeg mob kev txom nyem los ntawm cov kab hauv qab no:

• polyneuropathy, tsim tawm tsam keeb kwm ntawm ntshav qab zib mellitus thiab ntev cawv,
• steatohepatitis ntawm ntau lub hauv paus pib,
• mob siab steatosis
• rog hepatosis
• mob qaug dab peg.

Sab sij huam

Cov teebmeem hauv qab no tsis tuaj yeem pom thaum lub sijhawm kho nrog Berlition:

Urticaria

Rau txhua daim ntawv muab tshuaj:

• kev ua xua, uas tuaj yeem tshwm sim nws tus kheej ntawm urticaria (thaum siv cov ntawv txhaj, cov tshuaj tiv thaiv kev ua xua tuaj yeem tshwm sim anaphylaxis),
• qhov txo qis hauv cov piam thaj hauv ntshav, vim tias cov piam thaj yog qhov ua kom zoo dua.

Rau cov ntawv txhaj:

• cramps
• ob lub zeem muag
• intracranial hyperplasia thiab txog siav ua tsis taus pa (pom nrog kev tswj hwm sai ntawm kev siv tshuaj, cov teebmeem tsis xav dhau dhau ntawm nws tus kheej),
• thrombophlebitis
• pom cov ntshav tawm hauv cov tawv nqaij thiab cov qog ua kua,
• platelet tej,
• hemorrhagic pob,
• saj perversion
• hlawv ntawm qhov chaw txhaj tshuaj.

1 ntsiav tshuaj muaj 300 mg ntawm thioctic acid.

Raws li cov khoom siv ntxiv nws suav nrog:

• MCC
• ntxaib
• mis nyuj qab zib
• fumed silica,
• E 572,
• croscarmellose sodium.

Lub plhaub muaj cov tshuaj hauv qab no:

• titanium dawb
• kua paraffin
• hypromellose,
• sodium dodecyl sulfate,
• zas E104 thiab E110.

Hauv 1 ampoule ntawm kev mloog zoo rau kev npaj ntawm kev daws rau infusion, 300 lossis 600 mg ntawm cov tshuaj nquag yuav muaj.

Raws li cov tshuaj tiv thaiv cov tshuaj, cov mloog zoo muaj dej, ethylenediamine, thiab Berlition 300 kuj tseem muaj macrogol.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Thioctic acid yog ib qho tshuaj antioxidant. Raws li coenzyme ntawm mitochondrial multienzyme complexes, nws koom nrog oxidative carboxylation ntawm propanonic acid thiab alpha-keto acids.

Nws txo qis theem ntawm cov piam thaj hauv cov ntshav thiab ua rau kev nce siab ntawm glycogen hauv daim siab, pab kom kov yeej cov tshuaj insulin. Regulates cov metabolism hauv lipids thiab carbohydrates, txhim kho daim siab ua haujlwm. Lowers theem ntawm cov piam thaj, lipids thiab cov cholesterol nyob rau hauv cov ntshav, muaj cov nyhuv hepatoprotective.

Thaum noj ntawm qhov ncauj, nws yog qhov zoo nqus los ntawm txoj hnyuv, thaum tib lub sijhawm nrog zaub mov, cov qib ntawm adsorption poob qis. Nrog kev tswj hwm ntawm cov leeg, qhov siab tshaj plaws tau pom tom qab 10 feeb, thaum noj ntawm qhov ncauj tom qab 40-60 feeb.

Kis los ntawm daim siab, cov tshuaj nquag ua haujlwm yog metabolized, nws yog tawm los ntawm lub raum.

Cov nqe lus ntawm kev yuav khoom thiab chaw cia khoom

Koj tuaj yeem yuav cov tshuaj raws li kws kho mob sau ntawv yuav.

Nws yog ib qho tsim nyog yuav tsum tau khaws cov ntawv zoo li ntawm qhov kub tsis tshaj 25 degrees ntawm qhov chaw tsaus uas me nyuam yaus tsis tuaj yeem tau.

Cov tshuaj yuav tsum tsis tsum khov.

Lub txee lub neej ntawm kev tswj hwm yog 36 lub hlis.

Cov ntsiav tshuaj yuav tsum tau muab cia rau hauv qhov chaw ncav cuag rau me nyuam, ntawm qhov kub tsis tshaj 25 degrees. Txee lub neej yog 24 lub hlis.

(Cia koj rov los saib dua hauv cov lus)

* - Qhov txiaj ntsig nruab nrab ntawm ntau tus neeg muag khoom thaum lub sijhawm tshuaj xyuas tsis yog pej xeem kev pom

Berlition tus nqi, qhov twg yuav

Hauv Lavxias, tus nqi nruab nrab ntawm Berlition 600 hauv ampoules No. 5 yog 900 rubles, thiab Berlition 300 hauv ampoules No. 5 yog 600 rubles. Tus nqi ntawm Berlition 600 hauv tshuaj ntsiav Zauv 30 yog kwv yees li 1000 rubles. Tus nqi ntawm Berlition 300 hauv ntsiav tshuaj No. 30 yog kwv yees li 800 rubles.

Nyob rau hauv Ukraine (suav nrog Kiev, Kharkov, Odessa, thiab lwm yam) Berlition ntawm qhov nruab nrab tuaj yeem yuav: ampoules 300 No. 5 - 280 hryvnia, ampoules 600 No. 5 - 540 hryvnia, tsiav tshuaj 300 No. 30 - 400 hryvnia, tsiav tshuaj 600 Tsis tau 30 - 580 hryvnia , ntsiav tshuaj 300 No. 30 - 380 hryvnias.